222:. Two Phase 2/3 trials in patients with dry eye and neurotrophic keratopathy have been completed in the United States with promising results. A third Phase 3 trial in dry eye will begin in 2019. RegeneRx Biopharmaceuticals is developing an injectable form of Tβ4 for internal indications such as myocardial infarction, stroke, multiple sclerosis, brain trauma, and peripheral neuropathy. Dr. Goldstein's research has helped define the role of biological response modifiers in health and disease, and has led to the discovery of important new links between the
31:
259:. Over the years, Dr. Goldstein's laboratory has been a center for the training of graduate, medical, and postdoctoral students, many of whom are now continuing and expanding his studies on the role of the thymus in health and disease. Dr. Goldstein has also been a pioneer in medical education, having developed a unique series of distance-education programs presented on the Internet entitled
218:β4 (Tβ4), the second of the thymosins to reach the clinic, has been shown to accelerate wound healing and the remodeling of injured tissues. An injectable form of Tβ4 has been developed for internal indications such as myocardial infarction, stroke and brain trauma. Early Phase 2 trials have been completed in patients with pressure and
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Danielli, Riccardo; Cisternino, Filomena; Giannarelli, Diana; Calabrò, Luana; Camerini, Roberto; Savelli, Vinno; Bova, Giovanni; Dragonetti, Rosella; Di
Giacomo, Anna Maria (July 2018). "Long-term follow up of metastatic melanoma patients treated with Thymosin alpha-1: investigating immune
279:
Dr. Goldstein was the co-founder and first president and scientific director of the
Institute for Advanced Studies in Aging and Geriatric Medicine, a nonprofit research institute that supports research and educational activities. He also served as a member of the board of trustees of the
284:
and of the board of directors of the
Richard B. and Lynn V. Cheney Cardiovascular Institute. Currently, he serves as the chairman of the board and chief scientific advisor for RegeneRx Biopharmaceuticals, a public company developing novel wound-healing and remodeling therapeutics.
263:. This series of lectures and national town forums by leading scientists focused on cutting-edge research. The broadcasts, which were presented live from George Washington University, began in 1997 and were a first for continuing medical education on the Internet.
197:
Thymosin α1 (TA1), a molecule with immune enhancing properties, was the first of the thymosins to enter clinical trials. It has been approved in China and more than 30 other countries, and has shown great promise in the treatment of severe
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145:. He chaired the department from 1978 until March 2009 and was awarded emeritus status in 2013. He is an authority on the thymus gland and the workings of the immune system, and co-discoverer (with Abraham White) of the
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Dr. Goldstein is the author of more than 450 scientific articles in professional journals, the inventor on over 25 U.S. and worldwide patents, and the editor of several books and monographs in the fields of
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Bergsma, D. and
Goldstein, A.L. (eds.), Neurochemical and Immunologic Components in Schizophrenia. Birth Defects: Original Series, Vol XIV. The National Foundation, Alan R. Liss, Inc., New York, 1978.
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Dr. Goldstein is the recipient of several awards, including the Career
Scientist Award of the Health Research Council, City of New York; the Van Dyke Memorial Award in Pharmacology from the
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305:"in recognition and appreciation of outstanding work in helping to establish a national program on Biological Response Modifiers"; a Doctor of Science degree (honoris causa) from
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313:, in the rank of Commander, Panama's highest honor, for "contributions directed to the preservation of human life in the world"; the Distinguished Researcher Award of the
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Goldstein, A.L. and Garaci, E., Combination
Therapies: Biological Response Modifiers in the Treatment of Cancer and Infectious Diseases. Plenum Press, New York, 1992.
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Goldstein A.L., Hannappel E., Sosne G., Kleinman H.K. (2012). "Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications".
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Goldstein, A.L. (ed.), Thymic
Hormones and Lymphokines: Their Chemistry and Clinical Applications. Plenum Press, New York, 1984.
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210:. Most recently, TA1 has been found to synergize with a check-point inhibitor and further extend the survival of Stage III/IV
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Tuthill, Cynthia; Rios, Israel; McBeath, Randy (May 2010). "Thymosin alpha 1: past clinical experience and future promise".
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Department of
Biochemistry and Molecular Biology, The George Washington University School of Medicine and Health Sciences
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from 1972 through 1978 before accepting the chairmanship of the
Department of Biochemistry and Molecular Biology at the
744:"RGN-259 (Tβ4) Improves Clinically Important Dry Eye Efficacies in Comparison with Prescription Drugs in Dry Eye Model"
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Goldstein AL, Goldstein AL (May 2009). "From lab to bedside: emerging clinical applications of thymosin alpha 1".
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822:"Evidence that thymosins and other biological response modifiers can function as neuroactive immunotransmitters"
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is emeritus professor in the
Department of Biochemistry and Molecular Medicine at the
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365:"The Expanding Role of Thymosins | The School of Medicine & Health Sciences"
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from 1964 to 1972, and as director of the Division of Biochemistry at the
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968:"Institute for Advanced Studies in Aging and Geriatric Medicine, IASIA"
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549:"From thymus to cystic fibrosis: the amazing life of thymosin alpha 1"
206:, and a number of other diseases including the potential treatment of
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George Washington University School of Medicine & Health Sciences
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Goldstein A.L. (2007). "History of the Discovery of the Thymosins".
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Goldstein, A.L. (ed) Frontiers in Biomedicine, Plenum Press 2000.
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Hall N.R., McGillis J.P., Spangelo B.L., Goldstein A.L. (1985).
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received the FREDDIE award for best health site at the 1997
321:, the highest civilian award of France. He was elected to
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722:"RegeneRx Reports Phase II Venous Stasis Trial Results"
271:
Health and Medicine film competition in San Francisco.
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Columbia University College of Physicians and Surgeons
177:, the latter in 1964. He served on the faculty of the
1018:"Bloomberg - Allan L. Goldstein: Executive Profile"
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112:
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315:George Washington University School of Medicine
183:University of Texas Medical Branch in Galveston
143:George Washington University School of Medicine
325:, the National Medical Honor Society in 2007.
770:"RegeneRx Partner Updates on Clinical Trials"
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868:: CS1 maint: multiple names: authors list (
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173:in 1959 and his M.S. and Ph.D. degrees from
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117:George Washington University Medical School
482:Annals of the New York Academy of Sciences
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214:patients previously treated with TA1.
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1093:George Washington University faculty
607:Expert Opinion on Biological Therapy
553:Expert Opinion on Biological Therapy
189:, a position he held for 31 years.
179:Albert Einstein College of Medicine
169:and received his B.S. degree from
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502:10.1111/j.1749-6632.2010.05482.x
319:Chevalier des Palmes Académiques
1098:Academics from New York (state)
16:American biochemist (born 1937)
367:. George Washington University
311:Order of Vasco Núñez de Balboa
282:Albert Sabin Vaccine Institute
1:
1073:American molecular biologists
619:10.1080/14712598.2018.1494717
566:10.1080/14712598.2018.1484447
678:10.1517/14712598.2012.634793
269:American Medical Association
149:, a family of hormone-like
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920:"Bloomberg - Javier Paino"
839:10.4049/jimmunol.135.2.806
1103:Academics from New Jersey
1078:Rutgers University alumni
451:10.1517/14712590902911412
299:U.S. Department of Health
132:
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309:; the Decoration of the
161:Early life and education
942:"Frontiers in Medicine"
666:Expert Opin. Biol. Ther
547:Garaci, Enrico (2018).
408:10.1196/annals.1415.045
275:Professional activities
1068:American geriatricians
832:(2 Suppl): 806s–811s.
605:checkpoints synergy".
1083:Wagner College alumni
826:Journal of Immunology
439:Expert Opin Biol Ther
303:Education and Welfare
265:Frontiers in Medicine
261:Frontiers in Medicine
238:Academic achievements
228:neuroendocrine system
165:Goldstein grew up on
796:"RGN-352 | RegeneRx"
494:2010NYASA1194..130T
400:2007NYASA1112....1G
388:Ann. N.Y. Acad. Sci
776:. October 29, 2018
175:Rutgers University
153:isolated from the
139:Allan L. Goldstein
68:Rutgers University
23:Allan L. Goldstein
220:venostasis ulcers
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113:Institutions
103:Biochemistry
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1058:1937 births
1024:February 1,
1020:. Bloomberg
1002:February 1,
998:. Bloomberg
977:February 1,
926:February 1,
922:. Bloomberg
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780:February 1,
754:February 1,
728:February 1,
394:(1): 1–13.
371:February 1,
340:Thymosin α1
249:biomedicine
1052:Categories
351:References
317:, and the
253:immunology
107:immunology
44:1937-11-08
635:768086347
627:1744-7682
583:644930062
575:1471-2598
510:0077-8923
335:Thymosins
147:thymosins
86:thymosins
856:41775691
800:RegeneRx
774:RegeneRx
748:RegeneRx
686:22074294
651:51890800
643:30063847
591:30063868
534:20597852
526:20536460
518:57215385
467:71893579
459:19392576
416:17600284
329:See also
230:and the
216:Thymosin
212:melanoma
193:Research
151:peptides
848:2861235
694:5237443
490:Bibcode
424:3177237
396:Bibcode
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226:, the
204:cancer
200:sepsis
99:Fields
71:(M.S.)
64:(B.S.)
852:S2CID
690:S2CID
647:S2CID
530:S2CID
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420:S2CID
232:brain
1026:2019
1004:2019
979:2019
954:2018
928:2019
870:link
844:PMID
807:2019
782:2019
756:2019
730:2019
708:link
682:PMID
639:PMID
631:OCLC
623:ISSN
587:PMID
579:OCLC
571:ISSN
522:PMID
514:OCLC
506:ISSN
486:1194
455:PMID
412:PMID
392:1112
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255:and
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