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progress of the disease slowed or stopped in many people receiving methotrexate, with the progression being completely halted in about 30% of those receiving the drug. Those individuals with rheumatoid arthritis treated with methotrexate have been found to have a lower risk of cardiovascular events such as
1122:
Methotrexate is one of the first-line therapies for the treatment of rheumatoid arthritis. Weekly doses of 5 to 25mg were found by a
Cochrane review to be beneficial for 12–52 weeks duration of therapy, though it is used longer-term in clinical practice. Discontinuation rates are as high as 16% due
1145:
Studies and reviews have found that most rheumatoid arthritis patients treated with methotrexate for up to one year had less pain, functioned better, had fewer swollen and tender joints, and had less disease activity overall as reported by themselves and their doctors. X-rays also showed that the
2885:
Flohr C, Rosala-Hallas A, Jones AP, Beattie P, Baron S, Browne F, et al. (November 2023). "Efficacy and safety of ciclosporin versus methotrexate in the treatment of severe atopic dermatitis in children and young people (TREAT): a multicentre parallel group assessor-blinded clinical trial".
2553:
Colebatch AN, Marks JL, Edwards CJ (November 2011). "Safety of non-steroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other
1628:
behind these effects was still unknown at the time. Other analogues of folic acid were in development, and by 1950, methotrexate (then known as amethopterin) was being proposed as a treatment for leukemia. Animal studies published in 1956 showed the
1565:
sensitivity of activated T cells; and inhibition of methyltransferase activity, leading to deactivation of enzyme activity relevant to immune system function. Another mechanism of MTX is the inhibition of the binding of
1624:. The development of folic acid analogues had been prompted by the discovery that the administration of folic acid worsened leukemia, and that a diet deficient in folic acid could, conversely, produce improvement; the
832:
149:
3509:
Brody M, Böhm I, Bauer R (October 1993). "Mechanism of action of methotrexate: experimental evidence that methotrexate blocks the binding of interleukin 1 beta to the interleukin 1 receptor on target cells".
1540:
For the treatment of rheumatoid arthritis, inhibition of DHFR is not thought to be the main mechanism, but rather multiple mechanisms appear to be involved, including the inhibition of enzymes involved in
3473:
Böhm I (June 2004). "Increased peripheral blood B-cells expressing the CD5 molecules in association to autoantibodies in patients with lupus erythematosus and evidence to selectively down-modulate them".
1002:
Methotrexate was first made in 1947 and initially was used to treat cancer, as it was less toxic than the then-current treatments. In 1956 it provided the first cures of a metastatic cancer. It is on the
874:
InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
2702:"Comparative Effectiveness of Combining MTX with Biologic Drug Therapy Versus Either MTX or Biologics Alone for Early Rheumatoid Arthritis in Adults: a Systematic Review and Network Meta-analysis"
351:
1455:
The coenzyme folic acid (top) and the anticancer drug methotrexate (bottom) are very similar in structure. As a result, methotrexate is a competitive inhibitor of many enzymes that use folates.
1320:
Methotrexate pneumonitis is a rare complication of therapy, and appears to be reducing in frequency in most recent rheumatoid arthritis treatment trials. In the context of rheumatoid arthritis
1032:, either alone or in combination with other agents. It is effective for the treatment of a number of cancers, including solid tumours of breast, head and neck, lung, bladder, as well as
9198:
9178:
296:
7187:
3157:"Executive Summary: British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids"
1056:
Although originally designed as a chemotherapy drug, in lower doses methotrexate is a generally safe and well-tolerated drug in the treatment of certain autoimmune diseases.
1138:
is relatively safe in people being treated for rheumatoid arthritis, with appropriate monitoring. Methotrexate is also sometimes used in combination with other conventional
9138:
1357:
Another little-understood but serious possible adverse effect of methotrexate is neurological damage and memory loss. Neurotoxicity may result from the drug crossing the
3810:
6984:
1997:
9153:
2945:"Current evidence on surgery, systemic methotrexate and expectant management in the treatment of tubal ectopic pregnancy: a systematic review and meta-analysis"
178:
3592:
Meyer LM, Miller FR, Rowen MJ, Bock G, Rutzky J (September 1950). "Treatment of acute leukemia with amethopterin (4-amino, 10-methyl pteroyl glutamic acid)".
5542:
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846:
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Scheinfeld N (December 2006). "Three cases of toxic skin eruptions associated with methotrexate and a compilation of methotrexate-induced skin eruptions".
1376:
may decrease the elimination of methotrexate, so increase the risk of toxicity. While they may be used together, increased monitoring is recommended. The
1644:, showing remission in breast cancer. Wright's group was the first to demonstrate use of the drug in solid tumors, as opposed to leukemias, which are a
1305:), increased risk of infection, hair loss, nausea, reduced appetite, abdominal pain, diarrhea, fatigue, fever, dizziness, drowsiness, headache, acute
7180:
6458:
1898:
1335:) and while breastfeeding. Guidelines have been updated to state that it is safe for a male partner to take at any point while trying to conceive.
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3155:
Russell MD, Dey M, Flint J, Davie P, Allen A, Crossley A, et al. (BSR Standards, Audit and
Guidelines Working Group) (November 2022).
1681:
1139:
1060:
3079:"Methotrexate-Associated Pneumonitis and Rheumatoid Arthritis-Interstitial Lung Disease: Current Concepts for the Diagnosis and Treatment"
3711:
Wright JC, Gumport SL, Golomb FM (November 1960). "Remissions produced with the use of
Methotrexate in patients with mycosis fungoides".
1983:
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type. It is thought to affect cancer and rheumatoid arthritis by two different pathways. For cancer, methotrexate competitively inhibits
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5093:
1407:
1127:
7543:
7523:
4245:
4201:
4079:
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987:, lymphoma, and severe skin rashes. People on long-term treatment should be regularly checked for side effects. It is not safe during
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6401:
5771:
4004:
1977:
945:
866:
3034:
Oliff A, Bleyer WA, Poplack DG (1 September 1979). "Methotrexate-induced oral mucositis and salivary methotrexate concentrations".
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of methotrexate was better than that of aminopterin, and clinical use of aminopterin was thus abandoned in favor of methotrexate.
5535:
3796:
2518:
American
Rheumatoid Arthritis Guidelines (February 2002). "Guidelines for the management of rheumatoid arthritis: 2002 Update".
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6970:
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4726:
4520:
3128:
Gromnica-Ihle E, Krüger K (1 September 2010). "Use of methotrexate in young patients with respect to the reproductive system".
1804:
1554:
485:
336:
210:
2294:"Management of cutaneous lupus erythematosus with low-dose methotrexate: indication for modulation of inflammatory mechanisms"
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4141:
4031:
3629:"An evaluation of folic acid antagonists in adults with neoplastic diseases: a study of 93 patients with incurable neoplasms"
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1583:
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synthesis. The affinity of methotrexate for DHFR is about 1000-fold that of dihydrofolate. DHFR catalyses the conversion of
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and damaging neurons in the cerebral cortex. People with cancer who receive the medication often nickname these effects "
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and it is advised stop taking it at least 4 weeks before becoming pregnant and it should be avoided during pregnancy (
719:
8345:
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3668:
Hertz R, Li MC, Spencer DB (November 1956). "Effect of methotrexate therapy upon choriocarcinoma and chorioadenoma".
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have been known to interact with methotrexate to produce additive hepatotoxicity and haematotoxicity, respectively.
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7453:
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2984:
2832:] To date, three small RCTs in SLE patients have been published, including in total 76 patients in the active arm
1923:
Bannwarth B, Labat L, Moride Y, Schaeverbeke T (January 1994). "Methotrexate in rheumatoid arthritis. An update".
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Image shows open bottle of methotrexate drug—one of the first chemotherapeutic drugs used in the early 1950s
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266:
2224:. AHRQ Comparative Effectiveness Reviews. Rockville (MD): Agency for Healthcare Research and Quality (US).
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Donahue KE, Schulman ER, Gartlehner G, Jonas BL, Coker-Schwimmer E, Patel SV, et al. (October 2019).
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have been found to increase the plasma concentrations of methotrexate, as have nephrotoxic agents such as
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1252:
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1041:
913:
431:
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3434:"Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis"
1890:
1827:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
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2846:"Non-biologic systemic treatments for atopic dermatitis: Current state of the art and future directions"
2653:"Protective effect of methotrexate in patients with rheumatoid arthritis and cardiovascular comorbidity"
2475:
Cronstein BN (June 2005). "Low-dose methotrexate: a mainstay in the treatment of rheumatoid arthritis".
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base biosynthesis, so synthesis will be inhibited. Methotrexate, therefore, inhibits the synthesis of
1011:. In 2021, it was the 132nd most commonly prescribed medication in the United States, with more than 4
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Central nervous system reactions to methotrexate have been reported, especially when given via the
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3334:"Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics"
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2500:
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Donahue KE, Gartlehner G, Schulman ER, Jonas B, Coker-Schwimmer E, Patel SV, et al. (2018).
1948:
1891:"Trexall, Rheumatrex (methotrexate) dosing, indications, interactions, adverse effects, and more"
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Tsang-A-Sjoe MW, Bultink IE (2015). "Systemic lupus erythematosus: review of synthetic drugs".
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3740:"Observations on the Use of Cancer Chemotherapeutic Agents in Patients With Mycosis Fungoides"
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Lopez-Olivo MA, Siddhanamatha HR, Shea B, Tugwell P, Wells GA, Suarez-Almazor ME (June 2014).
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2166:"Current Treatment Concepts for Extra-Abdominal Desmoid-Type Fibromatosis: A Narrative Review"
1973:
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inhibits methotrexate excretion, which increases the risk of methotrexate toxicity. Likewise,
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Results of a systematic review exploring the comparative effectiveness of treatments of early
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1354:. It has a variety of cutaneous side effects, particularly when administered in high doses.
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may potentiate methotrexate's haematologic effects, hence potentially leading to toxicity.
1259:). Doses are usually taken weekly, not daily, to limit toxicity. Routine monitoring of the
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treatment for a number of autoimmune diseases in adults, including rheumatoid arthritis,
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are recommended. Measurements of creatinine are recommended at least every two months.
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Common side effects include nausea, feeling tired, fever, increased risk of infection,
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2002:
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have also been found to fatally interact with methotrexate in numerous case reports.
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is commonly co-prescribed with methotrexate to minimise the risk of adverse effects.
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Rajagopalan PT, Zhang Z, McCourt L, Dwyer M, Benkovic SJ, Hammes GG (October 2002).
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1324:, methotrexate treatment may be associated with a lower incidence of ILD over time.
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potentiating the haematological toxicity of methotrexate has also been documented.
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2140:"Methotrexate 2.5 mg Tablets - Summary of Product Characteristics (SmPC) - (emc)"
1731:
1682:"methotrexate – definition of methotrexate in English from the Oxford dictionary"
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Wright JC, Lyons MM, Walker DG, Golomb FM, Gumport SL, Medrek TJ (August 1964).
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Proceedings of the
National Academy of Sciences of the United States of America
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5321:
5311:
5306:
5301:
5271:
5261:
5226:
5221:
5201:
5156:
5144:
5119:
5114:
5104:
5086:
5081:
5071:
5066:
5024:
5012:
5000:
4972:
4959:
4954:
4924:
4887:
4882:
4820:
4815:
4761:
4706:
4658:
4644:
4592:
4579:
4548:
4481:
4470:
4443:
4433:
4428:
4374:
4329:
4324:
4225:
4189:
4121:
4111:
4100:
4084:
4036:
4019:
3995:
3947:
3935:
3887:
3681:
1609:
1518:
1503:
1472:
1440:
1421:
1388:
1347:
1328:
1294:
1290:
1268:
1100:
996:
972:
808:
591:
7165:
3757:
10.1002/1097-0142(196408)17:8<1045::AID-CNCR2820170811>3.0.CO;2-S
2668:
2585:
2058:
World Health
Organization model list of essential medicines: 22nd list (2021)
40:
8991:
8941:
8857:
8825:
8681:
8608:
8598:
8510:
8450:
8440:
8260:
8215:
8012:
7785:
7693:
7688:
7673:
7558:
7508:
7483:
7355:
7305:
7260:
7043:
7007:
6926:
6921:
6906:
6881:
6836:
6816:
6776:
6711:
6675:
6597:
6393:
6346:
6275:
6241:
6208:
6018:
5998:
5907:
5807:
5647:
5468:
5448:
5403:
5393:
5387:
5291:
5236:
5185:
5109:
5099:
5054:
5041:
4982:
4944:
4872:
4810:
4751:
4740:
4696:
4653:
4612:
4606:
4602:
4564:
4491:
4486:
4476:
4448:
4408:
4369:
4344:
4334:
4294:
3940:
3930:
3925:
3920:
3882:
3095:
2961:
2944:
2182:
1546:
1506:
1432:
1428:
1387:
have been found to reduce gastrointestinal (GI) absorption of methotrexate.
1314:
1064:
953:
467:
182:
17:
3765:
3724:
3689:
3654:
3613:
3495:
3459:
3418:
3377:
3358:
3263:
3225:
3190:
3141:
3114:
2970:
2907:
2871:
2819:
2784:
2735:
2686:
2637:
2571:
2539:
2496:
2461:
2278:
2229:
2201:
2030:
World Health
Organization model list of essential medicines: 21st list 2019
1161:
show that treatment efficacy can be improved with combination therapy with
3541:
2899:
2317:
1944:
1199:
Along with other immunosuppressants, methotrexate is used to treat severe
1172:
Likewise, a 2016 study found the use of methotrexate, in combination with
8966:
8961:
8852:
8525:
8082:
7603:
7583:
7488:
7325:
6861:
6736:
6425:
5933:
5843:
5779:
5701:
5377:
5341:
5281:
5049:
4987:
4767:
4663:
4635:
4314:
4151:
3242:
Hafner DL (August 2009). "Lost in the fog: understanding "chemo brain"".
3055:
2348:(2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust.
1652:
and his collaborators then demonstrated complete remission in women with
1392:
1380:
1080:
941:
933:
571:
224:
2612:"Methotrexate in rheumatoid arthritis: a quarter century of development"
2066:
2038:
580:
9075:
9046:
9016:
8986:
8936:
8686:
8671:
8530:
8280:
8159:
8137:
7935:
7473:
7245:
7228:
6354:
4270:
4171:
3985:
3846:
3217:
3047:
2293:
2221:
Drug
Therapy for Early Rheumatoid Arthritis: A Systematic Review Update
1534:
1131:
1116:
1112:
526:
446:
3605:
3009:
2862:
2845:
2766:
2531:
2488:
2260:
9041:
9036:
8748:
7955:
7950:
7915:
7643:
6669:
6500:
3910:
1558:
1550:
1514:
1480:
1298:
1274:
1151:
917:
671:
2616:
Transactions of the
American Clinical and Climatological Association
3627:
Wright JC, Prigot A, Wright B, Weintraub S, Wright LT (July 1951).
1028:
Methotrexate was originally developed and continues to be used for
995:, lower doses may be needed. It acts by blocking the body's use of
640:
8505:
8067:
8007:
6368:
6221:
3077:
Fragoulis GE, Nikiphorou E, Larsen J, Korsten P, Conway R (2019).
1587:
1463:
Methotrexate (green) complexed into the active site of DHFR (blue)
1458:
1450:
1188:
1088:
831:
822:
707:
651:
2751:"Methotrexate for Inflammatory Bowel Diseases - New Developments"
854:
O=C((CCC(O)=O)NC(C1=CC=C(N(CC2=CN=C(N=C(N)N=C3N)C3=N2)C)C=C1)=O)O
8164:
7875:
7568:
7538:
6340:
6288:
6249:
6235:
5789:
5663:
3670:
Proceedings of the
Society for Experimental Biology and Medicine
3512:
European Journal of Clinical Chemistry and Clinical Biochemistry
1617:
1567:
1562:
631:
397:
369:
7169:
6966:
5524:
3792:
382:
219:
6197:
1834:
1526:
1522:
129:
8722:
8644:
8581:
2943:
Mol F, Mol BW, Ankum WM, van der Veen F, Hajenius PJ (2008).
724:
135:
87:
345:
251:
138:
114:
102:
90:
84:
2164:
Lee YS, Joo MW, Shin SH, Hong S, Chung YG (January 2024).
1660:
in 1956, and in 1960 Wright et al. produced remissions in
2844:
Paolino A, Alexander H, Broderick C, Flohr C (May 2023).
2042:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
358:
2586:"Methotrexate and its use in rheumatoid arthritis (RA)"
1005:
World Health Organization's List of Essential Medicines
891:
30:"Amethopterin" redirects here. Not to be confused with
1176:, has been shown to be effective for the treatment of
952:. Types of autoimmune diseases it is used for include
9101:
123:
111:
108:
105:
78:
3432:
Wessels JA, Huizinga TW, Guchelaar HJ (March 2008).
1557:
expression by T cells; selective down-regulation of
1243:
Methotrexate can be given by mouth or by injection (
436:
35–50% (parent drug), 91–93% (7-hydroxymethotrexate)
117:
99:
96:
8926:
8876:
8764:
8747:
8720:
8642:
8579:
8562:
8173:
7752:
7737:
7254:
7223:
7206:
7062:
7024:
7006:
6729:
6657:
6630:
6515:
6158:
5860:
5851:
5842:
5835:
5788:
5770:
5761:
5715:
5646:
5576:
5567:
5178:
5129:
4909:
4902:
4838:
4792:
4725:
4682:
4519:
4504:
4384:
4354:
4279:
4264:
4235:
4131:
4051:
3994:
3977:
3966:
3902:
3855:
3836:
1998:"Today's anti-cancer tools are ever better wielded"
820:
807:
774:
769:
750:
718:
690:
670:
650:
630:
610:
590:
570:
559:
550:
525:
505:
476:
466:
462:
3–10 hours (lower doses), 8–15 hours (higher doses)
453:
440:
430:
420:
412:
335:
330:
295:
265:
239:
209:
195:
177:
169:
159:
126:
93:
81:
69:
64:
7292:4'-O-β-D-Glucosyl-9-O-(6''-deoxysaccharosyl)olivil
2370:
1570:to its cell surface receptor. Thereby, it acts as
2377:(65 ed.). London, UK: Pharmaceutical Press.
1801:The American Society of Health-System Pharmacists
497:)-2-(methyl)amino}benzoyl)amino]pentanedioic acid
2428:"Methotrexate for treating rheumatoid arthritis"
1142:, such as sulfasalazine and hydroxychloroquine.
539:
2657:Therapeutic Advances in Musculoskeletal Disease
2213:
2211:
1191:, with tentative evidence to support such use.
1126:Use of low doses of methotrexate together with
514:
7759:
9199:World Health Organization essential medicines
8727:Tooltip Plasma membrane monoamine transporter
8649:Tooltip Equilibrative nucleoside transporters
8586:Tooltip Concentrative nucleoside transporters
7181:
6978:
5536:
3804:
27:Chemotherapy and immunosuppressant medication
8:
9179:Mammalian dihydrofolate reductase inhibitors
1036:, non-Hodgkin's lymphoma, osteosarcoma, and
228:
39:
3633:Journal of the National Medical Association
2922:Eczema in children: uncertainties addressed
2556:The Cochrane Database of Systematic Reviews
2432:The Cochrane Database of Systematic Reviews
1791:
1789:
1787:
1785:
1783:
1781:
1779:
1777:
1775:
1773:
1771:
1769:
1767:
405:In general: ℞ (Prescription only)
8761:
8576:
7749:
7220:
7188:
7174:
7166:
6985:
6971:
6963:
5857:
5848:
5839:
5767:
5573:
5543:
5529:
5521:
4906:
4516:
4276:
3991:
3974:
3852:
3811:
3797:
3789:
3237:
3235:
1765:
1763:
1761:
1759:
1757:
1755:
1753:
1751:
1749:
1747:
1169:, compared with methotrexate monotherapy.
928:. Types of cancers it is used for include
761:
738:
599:
9139:Antineoplastic and immunomodulating drugs
3755:
3644:
3523:
3449:
3408:
3393:"The molecular perspective: methotrexate"
3367:
3357:
3180:
3104:
3094:
2960:
2861:
2774:
2725:
2676:
2627:
2451:
2268:
2191:
2181:
2065:
2037:
1918:
1916:
1231:. Rarely, it is used in combination with
619:
426:60% at lower doses, less at higher doses.
8766:
2924:(Report). NIHR Evidence. 19 March 2024.
2243:Herfarth HH, Long MD, Isaacs KL (2012).
1640:demonstrated the use of methotrexate in
1285:The most common adverse effects include
9108:
3327:
3325:
3323:
3321:
3304:Martindale: The Complete Drug Reference
1673:
871:
851:
734:
579:
490:
201:
3567:. In Cronstein BN, Bertino JR (eds.).
3130:Clinical and Experimental Rheumatology
2339:
2337:
2335:
2245:"Methotrexate: underused and ignored?"
2112:"Methotrexate - Drug Usage Statistics"
1986:from the original on 16 February 2017.
1972:. John Wiley & Sons. p. 251.
1596:In 1947, a team of researchers led by
1044:. It is also used in the treatment of
977:breakdown of the skin inside the mouth
752:
472:Urine (80–100%), feces (small amounts)
38:
9154:Disease-modifying antirheumatic drugs
3293:
3291:
3289:
3287:
3285:
3283:
3281:
2396:
2394:
2134:
2132:
2060:. Geneva: World Health Organization.
2032:. Geneva: World Health Organization.
1885:
1883:
1881:
1879:
1877:
1495:. Tetrahydrofolate is needed for the
700:
679:
659:
187:
7:
3256:10.1097/01.nurse.0000358574.56241.2f
3036:Cancer Chemotherapy and Pharmacology
2706:Journal of General Internal Medicine
2292:Boehm IB, Boehm GA, Bauer R (1998).
2092:from the original on 15 January 2024
1901:from the original on 8 February 2014
1223:has not ruptured. Methotrexate with
1183:Methotrexate has also been used for
706:
318:
308:
165:Trexall, Rheumatrex, Otrexup, others
4080:ribonucleotide reductase inhibitors
3298:Brayfield A, ed. (6 January 2014).
1807:from the original on 8 October 2016
1235:to abort intrauterine pregnancies.
639:
530:
8148:Tetramethylpyrazine (ligustrazine)
4246:Ribonucleotide reductase inhibitor
4202:Ribonucleotide reductase inhibitor
3565:"Methotrexate: historical aspects"
2888:The British Journal of Dermatology
2651:Marks JL, Edwards CJ (June 2012).
2369:Joint Formulary Committee (2013).
1103:. In children, it can be used for
25:
4005:Dihydrofolate reductase inhibitor
3476:Biomedicine & Pharmacotherapy
3010:"BNF is only available in the UK"
2850:Clinical and Experimental Allergy
2800:Expert Opinion on Pharmacotherapy
1007:. Methotrexate is available as a
979:. Other side effects may include
946:gestational trophoblastic disease
9111:
2373:British National Formulary (BNF)
1937:10.2165/00003495-199447010-00003
1513:. Also, folate is essential for
792:
786:
74:
56:
47:
1555:intercellular adhesion molecule
879:Key:FBOZXECLQNJBKD-ZDUSSCGKSA-N
7764:Tooltip Adenosine triphosphate
4142:Thymidylate synthase inhibitor
4032:Thymidylate synthase inhibitor
2749:Herfarth HH (1 January 2016).
2564:10.1002/14651858.CD008872.pub2
2444:10.1002/14651858.CD000957.pub2
1717:Merriam-Webster.com Dictionary
1584:History of cancer chemotherapy
1553:activation and suppression of
1402:Other immunosuppressants like
1313:. Methotrexate can also cause
798:
780:
1:
9092:Receptor/signaling modulators
7454:8-Phenyl-1,3-dipropylxanthine
4062:Adenosine deaminase inhibitor
3903:Block microtubule disassembly
3410:10.1634/theoncologist.4-4-340
2812:10.1517/14656566.2015.1101448
2346:Australian Medicines Handbook
1545:, leading to accumulation of
1109:juvenile idiopathic arthritis
5608:dihydroorotate dehydrogenase
3785:MedlinePlus article from NIH
3488:10.1016/j.biopha.2004.04.010
3173:10.1093/rheumatology/keac558
1622:acute lymphoblastic leukemia
1189:systemic lupus erythematosus
1187:and is used occasionally in
5587:purine synthesis inhibitors
3713:Cancer Chemotherapy Reports
3534:10.1515/cclm.1993.31.10.667
3451:10.1093/rheumatology/kem279
3391:Goodsell DS (August 1999).
2310:10.1515/cclm.1993.31.10.667
1034:acute lymphocytic leukemias
973:low white blood cell counts
9215:
8594:6-Hydroxy-7-methoxyflavone
7301:-ethylcarboxamidoadenosine
3206:Dermatology Online Journal
2930:10.3310/nihrevidence_62438
2718:10.1007/s11606-019-05230-0
2070:. WHO/MHP/HPS/EML/2021.02.
1581:
1059:Methotrexate is used as a
770:Chemical and physical data
29:
9085:
7126:
5772:IL-1 receptor antagonists
5481:
5362:Omacetaxine mepesuccinate
5242:Ciltacabtagene autoleucel
5232:Brexucabtagene autoleucel
3682:10.3181/00379727-93-22757
2949:Human Reproduction Update
2054:World Health Organization
2026:World Health Organization
1969:Drug Discovery: A History
1860:European Medicines Agency
1737:Dictionary.com Unabridged
1616:of Lederle, could induce
1483:that participates in the
1322:interstitial lung disease
914:immune-system suppressant
887:
862:
842:
481:
55:
46:
9169:IARC Group 3 carcinogens
8771:Tooltip Xanthine oxidase
6645:Anti-lymphocyte globulin
5414:Talimogene laherparepvec
5347:Nadofaragene firadenovec
5317:Lisocabtagene maraleucel
4266:Topoisomerase inhibitors
4185:DNA polymerase inhibitor
2669:10.1177/1759720X11436239
2520:Arthritis and Rheumatism
1105:juvenile dermatomyositis
8361:UDP-N-acetylglucosamine
6640:Anti-thymocyte globulin
5552:Immunosuppressive drugs
5217:Axicabtagene ciloleucel
3821:chemotherapeutic agents
3096:10.3389/fmed.2019.00238
2477:Pharmacological Reviews
2183:10.3390/cancers16020273
1477:dihydrofolate reductase
1293:, blood abnormalities (
1046:aggressive fibromatosis
1042:trophoblastic neoplasms
1015:million prescriptions.
8805:Cinnamomum osmophloeum
7514:Choline theophyllinate
7039:Sodium aurothiosulfate
6445:Interleukin-6 receptor
5871:Complement component 5
5399:Sitimagene ceradenovec
5297:Idecabtagene vicleucel
4862:Methyl aminolevulinate
3783:Methotrexate Injection
3359:10.1073/pnas.172501499
3306:. Pharmaceutical Press
1686:OxfordDictionaries.com
1593:
1464:
1456:
1418:Proton-pump inhibitors
1225:dilation and curettage
1148:myocardial infarctions
1134:or analgesics such as
1077:enteropathic arthritis
916:. It is used to treat
8048:Opiranserin (VVZ-149)
7389:-Cyclopentyladenosine
7034:Sodium aurothiomalate
4873:Porphyrin derivatives
4569:Melphalan flufenamide
4216:Hypomethylating agent
3825:antineoplastic agents
3571:. Basel: Birkhäuser.
3136:(5 Suppl 61): S80-4.
3083:Frontiers in Medicine
2962:10.1093/humupd/dmn012
2610:Weinblatt ME (2013).
2554:spondyloarthritis)".
2344:Rossi S, ed. (2013).
2082:"The Top 300 of 2021"
1614:Yellapragada Subbarao
1591:
1462:
1454:
1352:leukoencephalopathies
1215:and is used to treat
1117:localised scleroderma
8847:Pistacia integerrima
8153:Ligusticum wallichii
8131:Ligusticum wallichii
7459:8-Phenyltheophylline
7449:8-Chlorotheophylline
7399:Neladenoson dalanate
5202:Asparagine depleters
5131:Receptor antagonists
5045:+abiraterone acetate
2144:www.medicines.org.uk
1646:cancer of the marrow
1333:pregnancy category X
1265:liver function tests
1261:complete blood count
1167:biologic medications
1159:rheumatoid arthritis
1123:to adverse effects.
1099:, and many forms of
1052:Autoimmune disorders
958:rheumatoid arthritis
904:, formerly known as
6997:products / DMARDs (
5252:Denileukin diftitox
5152:Retinoid X receptor
4852:Aminolevulinic acid
4674:Triethylenemelamine
4506:Crosslinking of DNA
4237:Deoxyribonucleotide
4176:+gimeracil/oteracil
3563:Bertino JR (2000).
3350:2002PNAS...9913481R
2900:10.1093/bjd/ljad281
2006:. 14 September 2017
1626:mechanism of action
1467:Methotrexate is an
1447:Mechanism of action
1359:blood–brain barrier
1344:cerebrospinal fluid
1342:(directly into the
1217:ectopic pregnancies
1211:Methotrexate is an
1069:psoriatic arthritis
926:ectopic pregnancies
922:autoimmune diseases
378:(Prescription only)
354:(Prescription only)
43:
9174:Immunosuppressants
7153:Never to phase III
7083:Hydroxychloroquine
6802:Diroximel fumarate
6475:IL-2 receptor/CD25
5903:Certolizumab pegol
5556:Immunosuppressants
5508:Never to phase III
4310:Etirinotecan pegol
3594:Acta Haematologica
3218:10.5070/D30NQ2C0BX
3048:10.1007/BF00258300
2985:"Medical abortion"
2755:Digestive Diseases
2255:(Suppl 3): 112–8.
2249:Digestive Diseases
1966:Sneader W (2005).
1895:Medscape Reference
1720:. Merriam-Webster.
1692:on 22 October 2012
1594:
1568:interleukin 1-beta
1465:
1457:
1365:" or "chemo fog".
1185:multiple sclerosis
1178:ulcerative colitis
1085:systemic sclerosis
1073:reactive arthritis
1009:generic medication
964:. It can be given
910:chemotherapy agent
9099:
9098:
8922:
8921:
8899:Mycophenolic acid
8758:
8743:
8742:
8573:
8558:
8557:
8554:
8553:
8125:Angelica sinensis
7217:
7163:
7162:
7026:Gold preparations
6960:
6959:
6807:Efgartigimod alfa
6797:Dimethyl fumarate
6725:
6724:
6653:
6652:
6626:
6625:
5831:
5830:
5757:
5756:
5598:Mycophenolic acid
5518:
5517:
5477:
5476:
5434:Tigilanol tiglate
4911:Enzyme inhibitors
4834:
4833:
4830:
4829:
4530:Nitrogen mustards
4500:
4499:
4260:
4259:
3962:
3961:
3606:10.1159/000203749
3578:978-3-7643-5959-1
2863:10.1111/cea.14301
2767:10.1159/000443129
2712:(10): 2232–2245.
2532:10.1002/art.10148
2489:10.1124/pr.57.2.3
2384:978-0-85711-084-8
2355:978-0-9805790-9-3
2261:10.1159/000342735
1662:mycosis fungoides
1631:therapeutic index
1620:in children with
1543:purine metabolism
1369:Drug interactions
1346:), which include
1340:intrathecal route
1227:is used to treat
1201:atopic dermatitis
1195:Atopic dermatitis
1061:disease-modifying
1048:(desmoid tumor).
968:or by injection.
899:
898:
833:Interactive image
720:CompTox Dashboard
449:and intracellular
401:
386:
373:
361:
349:
255:
222:
173:MTX, amethopterin
16:(Redirected from
9206:
9116:
9115:
9114:
9107:
8772:
8768:
8762:
8752:
8728:
8724:
8650:
8646:
8587:
8583:
8577:
8567:
7961:Rheum officinale
7765:
7761:
7750:
7494:Caffeine citrate
7444:7-Methylxanthine
7277:-methyladenosine
7221:
7211:
7190:
7183:
7176:
7167:
6987:
6980:
6973:
6964:
6603:Telimomab aritox
6506:Zolimomab aritox
6327:CD62L/L-selectin
6065:Immunoglobulin E
5858:
5849:
5840:
5768:
5574:
5545:
5538:
5531:
5522:
5439:Tisagenlecleucel
5196:Arsenic trioxide
4907:
4840:Photosensitizers
4631:Alkyl sulfonates
4545:Cyclophosphamide
4517:
4456:Anthracenediones
4277:
4251:Hydroxycarbamide
3992:
3975:
3853:
3813:
3806:
3799:
3790:
3770:
3769:
3759:
3735:
3729:
3728:
3708:
3702:
3701:
3665:
3659:
3658:
3648:
3624:
3618:
3617:
3589:
3583:
3582:
3560:
3554:
3553:
3527:
3506:
3500:
3499:
3470:
3464:
3463:
3453:
3429:
3423:
3422:
3412:
3388:
3382:
3381:
3371:
3361:
3329:
3316:
3315:
3313:
3311:
3295:
3276:
3275:
3239:
3230:
3229:
3201:
3195:
3194:
3184:
3167:(4): 1370–1387.
3152:
3146:
3145:
3125:
3119:
3118:
3108:
3098:
3074:
3068:
3067:
3031:
3025:
3024:
3022:
3020:
3006:
3000:
2999:
2997:
2995:
2981:
2975:
2974:
2964:
2940:
2934:
2933:
2918:
2912:
2911:
2882:
2876:
2875:
2865:
2841:
2835:
2834:
2806:(18): 2793–806.
2795:
2789:
2788:
2778:
2746:
2740:
2739:
2729:
2697:
2691:
2690:
2680:
2648:
2642:
2641:
2631:
2607:
2601:
2600:
2598:
2596:
2582:
2576:
2575:
2558:(11): CD008872.
2550:
2544:
2543:
2515:
2509:
2508:
2472:
2466:
2465:
2455:
2423:
2417:
2416:
2414:
2412:
2406:Versus Arthritis
2398:
2389:
2388:
2376:
2366:
2360:
2359:
2341:
2330:
2329:
2289:
2283:
2282:
2272:
2240:
2234:
2233:
2215:
2206:
2205:
2195:
2185:
2161:
2155:
2154:
2152:
2150:
2136:
2127:
2126:
2124:
2122:
2108:
2102:
2101:
2099:
2097:
2078:
2072:
2071:
2069:
2050:
2044:
2043:
2041:
2022:
2016:
2015:
2013:
2011:
1994:
1988:
1987:
1963:
1957:
1956:
1920:
1911:
1910:
1908:
1906:
1887:
1872:
1871:
1869:
1867:
1852:
1846:
1845:
1843:
1841:
1831:nctr-crs.fda.gov
1823:
1817:
1816:
1814:
1812:
1793:
1742:
1741:
1728:
1722:
1721:
1708:
1702:
1701:
1699:
1697:
1688:. Archived from
1678:
1549:; inhibition of
1493:tetrahydrofolate
1485:tetrahydrofolate
1327:Methotrexate is
1311:renal impairment
1303:thrombocytopenia
1207:During pregnancy
1014:
991:. In those with
895:
894:
835:
815:
800:
794:
788:
782:
765:
754:
743:
742:
728:
726:
710:
704:
683:
663:
643:
623:
603:
583:
563:
543:
533:
532:
518:
458:
399:
396:
391:
384:
381:
371:
368:
360:
357:
347:
344:
322:
312:
253:
250:
232:
221:
218:
205:
191:
154:
153:
152:
151:
144:
141:
140:
137:
132:
131:
128:
125:
120:
119:
116:
113:
110:
107:
104:
101:
98:
95:
92:
89:
86:
83:
80:
60:
51:
44:
42:
21:
9214:
9213:
9209:
9208:
9207:
9205:
9204:
9203:
9124:
9123:
9122:
9112:
9110:
9102:
9100:
9095:
9081:
8918:
8872:
8770:
8751:
8739:
8726:
8716:
8712:Propentofylline
8662:Benzodiazepines
8648:
8638:
8585:
8566:
8550:
8169:
8120:Sodium ferulate
8088:Radix puerariae
8063:Phenolphthalein
7763:
7756:
7741:
7733:
7634:Propentofylline
7574:Isovaleric acid
7258:
7250:
7210:
7202:
7197:Purine receptor
7194:
7164:
7159:
7158:
7143:Clinical trials
7122:
7058:
7049:Aurothioglucose
7020:
7002:
6991:
6961:
6956:
6902:Rozanolixizumab
6787:Deucravacitinib
6721:
6649:
6622:
6511:
6160:
6154:
5862:
5827:
5784:
5763:
5753:
5711:
5651:
5642:
5578:Antimetabolites
5569:
5563:
5549:
5519:
5514:
5513:
5498:Clinical trials
5473:
5179:Other/ungrouped
5174:
5125:
4898:
4878:Porfimer sodium
4826:
4788:
4721:
4678:
4508:
4496:
4380:
4350:
4268:
4256:
4231:
4127:
4047:
3983:
3981:antimetabolites
3979:
3978:DNA precursors/
3970:
3968:DNA replication
3958:
3898:
3868:Vinca alkaloids
3844:
3832:
3817:
3779:
3774:
3773:
3737:
3736:
3732:
3710:
3709:
3705:
3667:
3666:
3662:
3626:
3625:
3621:
3591:
3590:
3586:
3579:
3562:
3561:
3557:
3525:10.1.1.633.8921
3508:
3507:
3503:
3472:
3471:
3467:
3431:
3430:
3426:
3390:
3389:
3385:
3344:(21): 13481–6.
3331:
3330:
3319:
3309:
3307:
3297:
3296:
3279:
3241:
3240:
3233:
3203:
3202:
3198:
3154:
3153:
3149:
3127:
3126:
3122:
3076:
3075:
3071:
3033:
3032:
3028:
3018:
3016:
3008:
3007:
3003:
2993:
2991:
2983:
2982:
2978:
2942:
2941:
2937:
2920:
2919:
2915:
2884:
2883:
2879:
2843:
2842:
2838:
2797:
2796:
2792:
2748:
2747:
2743:
2699:
2698:
2694:
2650:
2649:
2645:
2609:
2608:
2604:
2594:
2592:
2584:
2583:
2579:
2552:
2551:
2547:
2517:
2516:
2512:
2474:
2473:
2469:
2438:(6): CD000957.
2425:
2424:
2420:
2410:
2408:
2400:
2399:
2392:
2385:
2368:
2367:
2363:
2356:
2343:
2342:
2333:
2291:
2290:
2286:
2242:
2241:
2237:
2217:
2216:
2209:
2163:
2162:
2158:
2148:
2146:
2138:
2137:
2130:
2120:
2118:
2110:
2109:
2105:
2095:
2093:
2080:
2079:
2075:
2052:
2051:
2047:
2024:
2023:
2019:
2009:
2007:
1996:
1995:
1991:
1980:
1965:
1964:
1960:
1922:
1921:
1914:
1904:
1902:
1889:
1888:
1875:
1865:
1863:
1862:. 29 March 2017
1854:
1853:
1849:
1839:
1837:
1825:
1824:
1820:
1810:
1808:
1795:
1794:
1745:
1730:
1729:
1725:
1710:
1709:
1705:
1695:
1693:
1680:
1679:
1675:
1670:
1654:choriocarcinoma
1586:
1580:
1509:, required for
1449:
1378:aminoglycosides
1371:
1283:
1281:Adverse effects
1241:
1229:molar pregnancy
1219:, provided the
1209:
1197:
1174:anti-TNF agents
1097:Crohn's disease
1054:
1038:choriocarcinoma
1026:
1021:
1012:
993:kidney problems
962:Crohn's disease
890:
888:
883:
880:
875:
870:
869:
858:
855:
850:
849:
838:
813:
803:
797:
791:
785:
746:
722:
714:
686:
666:
646:
626:
606:
586:
566:
546:
529:
521:
501:
498:
489:
488:
456:
432:Protein binding
422:Bioavailability
414:Pharmacokinetic
408:
389:
326:
268:
261:
242:
235:
148:
147:
146:
134:
122:
77:
73:
35:
28:
23:
22:
15:
12:
11:
5:
9212:
9210:
9202:
9201:
9196:
9191:
9186:
9184:Abortifacients
9181:
9176:
9171:
9166:
9161:
9156:
9151:
9146:
9141:
9136:
9126:
9125:
9121:
9120:
9097:
9096:
9086:
9083:
9082:
9080:
9079:
9065:
9064:
9059:
9054:
9049:
9044:
9039:
9034:
9029:
9024:
9019:
9014:
9009:
9004:
8999:
8994:
8989:
8984:
8979:
8974:
8969:
8964:
8959:
8954:
8949:
8944:
8939:
8930:
8928:
8924:
8923:
8920:
8919:
8917:
8916:
8911:
8906:
8901:
8896:
8891:
8886:
8880:
8878:
8874:
8873:
8871:
8870:
8865:
8860:
8855:
8850:
8843:
8838:
8833:
8828:
8823:
8818:
8813:
8808:
8801:
8799:Cinnamaldehyde
8796:
8791:
8786:
8781:
8775:
8773:
8759:
8745:
8744:
8741:
8740:
8738:
8737:
8731:
8729:
8718:
8717:
8715:
8714:
8709:
8704:
8702:Pentoxifylline
8699:
8694:
8689:
8684:
8679:
8674:
8669:
8664:
8659:
8653:
8651:
8640:
8639:
8637:
8636:
8631:
8626:
8621:
8616:
8611:
8606:
8601:
8596:
8590:
8588:
8574:
8560:
8559:
8556:
8555:
8552:
8551:
8549:
8548:
8543:
8538:
8533:
8528:
8523:
8518:
8513:
8508:
8503:
8498:
8493:
8488:
8483:
8478:
8473:
8468:
8463:
8458:
8453:
8448:
8443:
8438:
8433:
8428:
8423:
8418:
8413:
8408:
8403:
8398:
8393:
8388:
8379:
8378:
8373:
8368:
8363:
8358:
8353:
8348:
8343:
8338:
8333:
8328:
8323:
8318:
8313:
8308:
8303:
8298:
8293:
8288:
8283:
8278:
8273:
8268:
8263:
8258:
8253:
8248:
8243:
8238:
8233:
8228:
8223:
8218:
8213:
8208:
8203:
8198:
8193:
8188:
8179:
8177:
8171:
8170:
8168:
8167:
8162:
8157:
8145:
8140:
8135:
8117:
8112:
8107:
8102:
8097:
8092:
8080:
8075:
8070:
8065:
8060:
8055:
8050:
8045:
8040:
8035:
8030:
8025:
8020:
8015:
8010:
8005:
8000:
7995:
7990:
7985:
7980:
7975:
7970:
7965:
7953:
7948:
7943:
7938:
7933:
7928:
7923:
7918:
7913:
7908:
7903:
7898:
7893:
7888:
7879:
7878:
7873:
7868:
7863:
7858:
7853:
7848:
7843:
7838:
7833:
7828:
7823:
7818:
7813:
7808:
7803:
7798:
7793:
7788:
7783:
7778:
7769:
7767:
7747:
7735:
7734:
7732:
7731:
7726:
7721:
7716:
7711:
7706:
7701:
7696:
7691:
7686:
7681:
7676:
7671:
7666:
7661:
7656:
7651:
7646:
7641:
7636:
7631:
7626:
7624:Pentoxifylline
7621:
7616:
7611:
7606:
7601:
7596:
7591:
7586:
7581:
7579:Istradefylline
7576:
7571:
7566:
7561:
7556:
7551:
7546:
7541:
7536:
7531:
7526:
7521:
7516:
7511:
7506:
7501:
7496:
7491:
7486:
7481:
7476:
7471:
7466:
7461:
7456:
7451:
7446:
7437:
7436:
7431:
7426:
7421:
7416:
7411:
7406:
7401:
7396:
7391:
7383:
7378:
7373:
7368:
7363:
7358:
7353:
7348:
7343:
7338:
7333:
7328:
7323:
7318:
7313:
7308:
7303:
7294:
7289:
7284:
7279:
7273:2-(1-Hexynyl)-
7266:
7264:
7252:
7251:
7249:
7248:
7243:
7241:8-Aminoadenine
7234:
7232:
7218:
7204:
7203:
7195:
7193:
7192:
7185:
7178:
7170:
7161:
7160:
7157:
7156:
7155:
7154:
7151:
7140:
7134:
7128:
7127:
7124:
7123:
7121:
7120:
7108:
7096:
7090:
7085:
7076:
7066:
7064:
7060:
7059:
7057:
7056:
7051:
7046:
7041:
7036:
7030:
7028:
7022:
7021:
7019:
7018:
7012:
7010:
7004:
7003:
6992:
6990:
6989:
6982:
6975:
6967:
6958:
6957:
6955:
6954:
6949:
6944:
6939:
6934:
6929:
6924:
6919:
6914:
6909:
6904:
6899:
6894:
6889:
6884:
6879:
6874:
6869:
6864:
6859:
6854:
6849:
6844:
6839:
6834:
6829:
6824:
6819:
6814:
6811:+hyaluronidase
6804:
6799:
6794:
6792:Deuruxolitinib
6789:
6784:
6779:
6774:
6769:
6764:
6759:
6754:
6749:
6744:
6739:
6733:
6731:
6727:
6726:
6723:
6722:
6720:
6719:
6714:
6709:
6704:
6703:
6702:
6697:
6685:
6684:
6683:
6678:
6665:
6663:
6655:
6654:
6651:
6650:
6648:
6647:
6642:
6636:
6634:
6628:
6627:
6624:
6623:
6621:
6620:
6615:
6610:
6605:
6600:
6595:
6590:
6585:
6580:
6575:
6570:
6565:
6560:
6555:
6550:
6545:
6540:
6535:
6530:
6525:
6519:
6517:
6513:
6512:
6510:
6509:
6496:
6495:
6494:
6493:
6488:
6483:
6470:
6469:
6468:
6467:
6455:
6454:
6453:
6441:
6440:
6439:
6434:
6422:
6421:
6420:
6415:
6410:
6398:
6397:
6396:
6385:
6384:
6383:
6382:
6377:
6365:
6364:
6363:
6351:
6350:
6349:
6337:
6336:
6335:
6323:
6322:
6321:
6316:
6304:
6303:
6302:
6297:
6285:
6284:
6283:
6278:
6273:
6268:
6265:+hyaluronidase
6258:
6246:
6245:
6244:
6232:
6231:
6230:
6218:
6217:
6216:
6211:
6206:
6194:
6193:
6192:
6187:
6182:
6177:
6164:
6162:
6156:
6155:
6153:
6152:
6151:
6150:
6137:
6136:
6135:
6134:
6129:
6108:
6107:
6106:
6105:
6092:
6091:
6090:
6089:
6076:
6075:
6074:
6073:
6060:
6059:
6058:
6057:
6044:
6043:
6042:
6041:
6036:
6031:
6026:
6021:
6016:
6011:
6006:
6001:
5996:
5991:
5986:
5981:
5976:
5971:
5966:
5961:
5956:
5951:
5946:
5941:
5936:
5923:
5922:
5921:
5920:
5915:
5910:
5905:
5900:
5895:
5882:
5881:
5880:
5879:
5866:
5864:
5855:
5846:
5837:
5833:
5832:
5829:
5828:
5826:
5825:
5820:
5815:
5810:
5805:
5800:
5794:
5792:
5786:
5785:
5783:
5782:
5776:
5774:
5765:
5759:
5758:
5755:
5754:
5752:
5751:
5750:
5749:
5741:PDE4 inhibitor
5737:
5732:
5727:
5721:
5719:
5713:
5712:
5710:
5709:
5704:
5698:
5697:
5696:
5695:
5690:
5685:
5680:
5659:
5657:
5644:
5643:
5641:
5640:
5639:
5638:
5625:
5624:
5623:
5622:
5617:
5603:
5602:
5601:
5600:
5595:
5582:
5580:
5571:
5565:
5564:
5550:
5548:
5547:
5540:
5533:
5525:
5516:
5515:
5512:
5511:
5510:
5509:
5506:
5495:
5489:
5483:
5482:
5479:
5478:
5475:
5474:
5472:
5471:
5466:
5461:
5456:
5451:
5446:
5441:
5436:
5431:
5426:
5421:
5416:
5411:
5406:
5401:
5396:
5391:
5385:
5374:
5369:
5364:
5359:
5354:
5349:
5344:
5339:
5334:
5329:
5324:
5319:
5314:
5309:
5304:
5299:
5294:
5289:
5284:
5279:
5274:
5269:
5264:
5259:
5254:
5249:
5244:
5239:
5234:
5229:
5224:
5219:
5214:
5198:
5193:
5188:
5182:
5180:
5176:
5175:
5173:
5172:
5160:
5148:
5135:
5133:
5127:
5126:
5124:
5123:
5117:
5112:
5107:
5102:
5090:
5084:
5079:
5074:
5069:
5058:
5052:
5047:
5039:
5032:PARP inhibitor
5028:
5016:
5004:
4992:
4991:
4990:
4985:
4980:
4975:
4963:
4957:
4952:
4947:
4942:
4928:
4915:
4913:
4904:
4900:
4899:
4897:
4896:
4890:
4885:
4880:
4869:
4864:
4859:
4854:
4848:
4846:
4836:
4835:
4832:
4831:
4828:
4827:
4825:
4824:
4818:
4813:
4808:
4798:
4796:
4790:
4789:
4787:
4786:
4780:
4775:
4764:
4759:
4754:
4749:
4737:
4731:
4729:
4723:
4722:
4720:
4719:
4714:
4709:
4704:
4699:
4694:
4688:
4686:
4684:Platinum-based
4680:
4679:
4677:
4676:
4671:
4666:
4661:
4649:
4648:
4642:
4626:
4625:
4620:
4615:
4610:
4600:
4595:
4583:
4582:
4577:
4572:
4562:
4557:
4551:
4542:
4537:
4525:
4523:
4514:
4502:
4501:
4498:
4497:
4495:
4494:
4489:
4484:
4479:
4474:
4468:
4463:
4452:
4446:
4441:
4436:
4431:
4426:
4421:
4411:
4406:
4399:Anthracyclines
4394:
4392:
4382:
4381:
4379:
4378:
4372:
4360:
4358:
4352:
4351:
4349:
4348:
4342:
4337:
4332:
4327:
4322:
4317:
4312:
4307:
4302:
4297:
4285:
4283:
4274:
4262:
4261:
4258:
4257:
4255:
4254:
4241:
4239:
4233:
4232:
4230:
4229:
4223:
4211:
4210:
4197:
4196:
4180:
4179:
4169:
4164:
4159:
4154:
4149:
4137:
4135:
4129:
4128:
4126:
4125:
4119:
4117:Mercaptopurine
4108:
4103:
4098:
4092:
4087:
4071:
4070:
4057:
4055:
4049:
4048:
4046:
4045:
4039:
4028:
4022:
4017:
4012:
4000:
3998:
3989:
3972:
3964:
3963:
3960:
3959:
3957:
3956:
3944:
3938:
3933:
3928:
3923:
3918:
3906:
3904:
3900:
3899:
3897:
3896:
3890:
3885:
3880:
3875:
3863:
3861:
3850:
3834:
3833:
3819:Intracellular
3818:
3816:
3815:
3808:
3801:
3793:
3787:
3786:
3778:
3777:External links
3775:
3772:
3771:
3750:(8): 1045–62.
3730:
3703:
3660:
3619:
3584:
3577:
3555:
3518:(10): 667–74.
3501:
3465:
3424:
3397:The Oncologist
3383:
3317:
3300:"Methotrexate"
3277:
3231:
3196:
3147:
3120:
3069:
3042:(3): 225–226.
3026:
3001:
2976:
2935:
2913:
2894:(6): 674–684.
2877:
2856:(5): 495–510.
2836:
2790:
2761:(1–2): 140–6.
2741:
2692:
2643:
2602:
2577:
2545:
2510:
2467:
2418:
2402:"Methotrexate"
2390:
2383:
2361:
2354:
2331:
2284:
2235:
2207:
2156:
2128:
2103:
2073:
2045:
2017:
1989:
1978:
1958:
1912:
1873:
1856:"Jylamvo EPAR"
1847:
1818:
1797:"Methotrexate"
1743:
1740:(Online). n.d.
1732:"methotrexate"
1723:
1712:"methotrexate"
1703:
1672:
1671:
1669:
1666:
1638:Jane C. Wright
1579:
1576:
1491:to the active
1469:antimetabolite
1448:
1445:
1435:, the GI drug
1426:anticonvulsant
1370:
1367:
1287:hepatotoxicity
1282:
1279:
1240:
1239:Administration
1237:
1221:fallopian tube
1208:
1205:
1196:
1193:
1053:
1050:
1025:
1022:
1020:
1017:
897:
896:
885:
884:
882:
881:
878:
876:
873:
865:
864:
863:
860:
859:
857:
856:
853:
845:
844:
843:
840:
839:
837:
836:
828:
826:
818:
817:
811:
805:
804:
801:
795:
789:
783:
778:
772:
771:
767:
766:
756:
748:
747:
745:
744:
731:
729:
716:
715:
713:
712:
696:
694:
688:
687:
685:
684:
676:
674:
668:
667:
665:
664:
656:
654:
648:
647:
645:
644:
636:
634:
628:
627:
625:
624:
616:
614:
608:
607:
605:
604:
596:
594:
588:
587:
585:
584:
576:
574:
568:
567:
565:
564:
556:
554:
548:
547:
545:
544:
536:
534:
523:
522:
520:
519:
511:
509:
503:
502:
500:
499:
492:
484:
483:
482:
479:
478:
474:
473:
470:
464:
463:
460:
451:
450:
444:
438:
437:
434:
428:
427:
424:
418:
417:
410:
409:
407:
406:
403:
394:
379:
366:
355:
341:
339:
333:
332:
328:
327:
325:
324:
301:
299:
293:
292:
271:
269:administration
263:
262:
260:
259:
257:
247:
245:
237:
236:
234:
233:
215:
213:
207:
206:
199:
193:
192:
185:
175:
174:
171:
167:
166:
163:
157:
156:
71:
67:
66:
62:
61:
53:
52:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
9211:
9200:
9197:
9195:
9192:
9190:
9187:
9185:
9182:
9180:
9177:
9175:
9172:
9170:
9167:
9165:
9162:
9160:
9157:
9155:
9152:
9150:
9147:
9145:
9142:
9140:
9137:
9135:
9132:
9131:
9129:
9119:
9109:
9105:
9094:
9093:
9090:
9084:
9077:
9073:
9070:
9067:
9066:
9063:
9060:
9058:
9055:
9053:
9050:
9048:
9045:
9043:
9040:
9038:
9035:
9033:
9030:
9028:
9025:
9023:
9020:
9018:
9015:
9013:
9010:
9008:
9005:
9003:
9000:
8998:
8995:
8993:
8990:
8988:
8985:
8983:
8980:
8978:
8975:
8973:
8970:
8968:
8965:
8963:
8960:
8958:
8955:
8953:
8950:
8948:
8945:
8943:
8940:
8938:
8935:
8932:
8931:
8929:
8925:
8915:
8912:
8910:
8907:
8905:
8902:
8900:
8897:
8895:
8892:
8890:
8887:
8885:
8882:
8881:
8879:
8875:
8869:
8866:
8864:
8861:
8859:
8856:
8854:
8851:
8849:
8848:
8844:
8842:
8839:
8837:
8834:
8832:
8829:
8827:
8824:
8822:
8819:
8817:
8814:
8812:
8809:
8807:
8806:
8802:
8800:
8797:
8795:
8792:
8790:
8789:Benzbromarone
8787:
8785:
8782:
8780:
8777:
8776:
8774:
8769:
8763:
8760:
8756:
8750:
8746:
8736:
8733:
8732:
8730:
8725:
8719:
8713:
8710:
8708:
8705:
8703:
8700:
8698:
8695:
8693:
8690:
8688:
8685:
8683:
8680:
8678:
8675:
8673:
8670:
8668:
8665:
8663:
8660:
8658:
8655:
8654:
8652:
8647:
8641:
8635:
8632:
8630:
8627:
8625:
8622:
8620:
8617:
8615:
8612:
8610:
8607:
8605:
8602:
8600:
8597:
8595:
8592:
8591:
8589:
8584:
8578:
8575:
8571:
8565:
8561:
8547:
8544:
8542:
8539:
8537:
8534:
8532:
8529:
8527:
8524:
8522:
8519:
8517:
8514:
8512:
8509:
8507:
8504:
8502:
8499:
8497:
8494:
8492:
8489:
8487:
8484:
8482:
8479:
8477:
8474:
8472:
8469:
8467:
8464:
8462:
8459:
8457:
8454:
8452:
8449:
8447:
8444:
8442:
8439:
8437:
8434:
8432:
8429:
8427:
8424:
8422:
8421:AR-C 118925XX
8419:
8417:
8414:
8412:
8409:
8407:
8404:
8402:
8399:
8397:
8394:
8392:
8389:
8387:
8384:
8381:
8380:
8377:
8374:
8372:
8369:
8367:
8364:
8362:
8359:
8357:
8354:
8352:
8351:UDP-galactose
8349:
8347:
8344:
8342:
8339:
8337:
8334:
8332:
8329:
8327:
8324:
8322:
8319:
8317:
8314:
8312:
8309:
8307:
8304:
8302:
8299:
8297:
8294:
8292:
8289:
8287:
8284:
8282:
8279:
8277:
8274:
8272:
8269:
8267:
8264:
8262:
8259:
8257:
8254:
8252:
8249:
8247:
8244:
8242:
8239:
8237:
8234:
8232:
8229:
8227:
8224:
8222:
8219:
8217:
8214:
8212:
8209:
8207:
8204:
8202:
8199:
8197:
8194:
8192:
8189:
8187:
8184:
8181:
8180:
8178:
8176:
8172:
8166:
8163:
8161:
8158:
8155:
8154:
8149:
8146:
8144:
8141:
8139:
8136:
8133:
8132:
8127:
8126:
8121:
8118:
8116:
8113:
8111:
8108:
8106:
8103:
8101:
8098:
8096:
8093:
8090:
8089:
8084:
8081:
8079:
8076:
8074:
8071:
8069:
8066:
8064:
8061:
8059:
8056:
8054:
8051:
8049:
8046:
8044:
8041:
8039:
8036:
8034:
8031:
8029:
8026:
8024:
8021:
8019:
8016:
8014:
8011:
8009:
8006:
8004:
8001:
7999:
7996:
7994:
7991:
7989:
7986:
7984:
7981:
7979:
7976:
7974:
7971:
7969:
7966:
7963:
7962:
7957:
7954:
7952:
7949:
7947:
7946:Chelerythrine
7944:
7942:
7941:Calmidazolium
7939:
7937:
7934:
7932:
7929:
7927:
7924:
7922:
7919:
7917:
7914:
7912:
7909:
7907:
7904:
7902:
7899:
7897:
7894:
7892:
7889:
7887:
7884:
7881:
7880:
7877:
7874:
7872:
7869:
7867:
7864:
7862:
7859:
7857:
7854:
7852:
7849:
7847:
7844:
7842:
7839:
7837:
7834:
7832:
7829:
7827:
7826:Cibacron blue
7824:
7822:
7819:
7817:
7814:
7812:
7809:
7807:
7804:
7802:
7799:
7797:
7794:
7792:
7789:
7787:
7784:
7782:
7779:
7777:
7774:
7771:
7770:
7768:
7762:
7755:
7751:
7748:
7745:
7740:
7736:
7730:
7727:
7725:
7722:
7720:
7717:
7715:
7712:
7710:
7707:
7705:
7704:Theodrenaline
7702:
7700:
7697:
7695:
7692:
7690:
7687:
7685:
7682:
7680:
7677:
7675:
7672:
7670:
7667:
7665:
7662:
7660:
7657:
7655:
7652:
7650:
7647:
7645:
7642:
7640:
7639:Proxyphylline
7637:
7635:
7632:
7630:
7627:
7625:
7622:
7620:
7617:
7615:
7612:
7610:
7607:
7605:
7602:
7600:
7597:
7595:
7592:
7590:
7587:
7585:
7582:
7580:
7577:
7575:
7572:
7570:
7567:
7565:
7562:
7560:
7557:
7555:
7552:
7550:
7547:
7545:
7542:
7540:
7537:
7535:
7532:
7530:
7527:
7525:
7522:
7520:
7517:
7515:
7512:
7510:
7507:
7505:
7502:
7500:
7497:
7495:
7492:
7490:
7487:
7485:
7482:
7480:
7477:
7475:
7472:
7470:
7469:Aminophylline
7467:
7465:
7462:
7460:
7457:
7455:
7452:
7450:
7447:
7445:
7442:
7439:
7438:
7435:
7432:
7430:
7427:
7425:
7422:
7420:
7417:
7415:
7412:
7410:
7407:
7405:
7402:
7400:
7397:
7395:
7392:
7390:
7388:
7384:
7382:
7379:
7377:
7374:
7372:
7369:
7367:
7364:
7362:
7359:
7357:
7354:
7352:
7349:
7347:
7344:
7342:
7339:
7337:
7334:
7332:
7329:
7327:
7324:
7322:
7319:
7317:
7314:
7312:
7309:
7307:
7304:
7302:
7300:
7295:
7293:
7290:
7288:
7285:
7283:
7280:
7278:
7276:
7271:
7268:
7267:
7265:
7262:
7257:
7253:
7247:
7244:
7242:
7239:
7236:
7235:
7233:
7230:
7226:
7222:
7219:
7215:
7209:
7205:
7201:
7198:
7191:
7186:
7184:
7179:
7177:
7172:
7171:
7168:
7152:
7150:
7147:
7146:
7144:
7141:
7138:
7135:
7133:
7130:
7129:
7125:
7118:
7114:
7113:
7109:
7106:
7102:
7101:
7097:
7094:
7093:Sulfasalazine
7091:
7089:
7086:
7084:
7080:
7077:
7075:
7071:
7070:Penicillamine
7068:
7067:
7065:
7061:
7055:
7052:
7050:
7047:
7045:
7042:
7040:
7037:
7035:
7032:
7031:
7029:
7027:
7023:
7017:
7016:Oxycinchophen
7014:
7013:
7011:
7009:
7005:
7000:
6996:
6995:antirheumatic
6988:
6983:
6981:
6976:
6974:
6969:
6968:
6965:
6953:
6950:
6948:
6945:
6943:
6942:Tildrakizumab
6940:
6938:
6935:
6933:
6930:
6928:
6925:
6923:
6920:
6918:
6915:
6913:
6910:
6908:
6905:
6903:
6900:
6898:
6895:
6893:
6890:
6888:
6885:
6883:
6880:
6878:
6875:
6873:
6872:Pegcetacoplan
6870:
6868:
6865:
6863:
6860:
6858:
6855:
6853:
6850:
6848:
6845:
6843:
6840:
6838:
6835:
6833:
6830:
6828:
6825:
6823:
6820:
6818:
6815:
6812:
6808:
6805:
6803:
6800:
6798:
6795:
6793:
6790:
6788:
6785:
6783:
6782:Darvadstrocel
6780:
6778:
6775:
6773:
6770:
6768:
6765:
6763:
6760:
6758:
6755:
6753:
6750:
6748:
6745:
6743:
6740:
6738:
6735:
6734:
6732:
6728:
6718:
6715:
6713:
6710:
6708:
6705:
6701:
6698:
6696:
6693:
6692:
6691:
6690:
6689:TNF inhibitor
6686:
6682:
6679:
6677:
6674:
6673:
6672:
6671:
6667:
6666:
6664:
6661:
6656:
6646:
6643:
6641:
6638:
6637:
6635:
6633:
6629:
6619:
6616:
6614:
6611:
6609:
6606:
6604:
6601:
6599:
6596:
6594:
6591:
6589:
6586:
6584:
6581:
6579:
6576:
6574:
6571:
6569:
6566:
6564:
6561:
6559:
6556:
6554:
6551:
6549:
6546:
6544:
6541:
6539:
6536:
6534:
6531:
6529:
6526:
6524:
6521:
6520:
6518:
6514:
6507:
6503:
6502:
6498:
6497:
6492:
6489:
6487:
6484:
6482:
6479:
6478:
6477:
6476:
6472:
6471:
6466:
6463:
6462:
6461:
6460:
6456:
6452:
6449:
6448:
6447:
6446:
6442:
6438:
6435:
6433:
6430:
6429:
6428:
6427:
6423:
6419:
6416:
6414:
6411:
6409:
6406:
6405:
6404:
6403:
6399:
6395:
6392:
6391:
6390:
6387:
6386:
6381:
6378:
6376:
6373:
6372:
6371:
6370:
6366:
6362:
6359:
6358:
6357:
6356:
6355:CD147/Basigin
6352:
6348:
6345:
6344:
6343:
6342:
6338:
6334:
6331:
6330:
6329:
6328:
6324:
6320:
6317:
6315:
6312:
6311:
6310:
6309:
6305:
6301:
6298:
6296:
6293:
6292:
6291:
6290:
6286:
6282:
6279:
6277:
6274:
6272:
6269:
6266:
6262:
6259:
6257:
6254:
6253:
6252:
6251:
6247:
6243:
6240:
6239:
6238:
6237:
6233:
6229:
6226:
6225:
6224:
6223:
6219:
6215:
6212:
6210:
6207:
6205:
6202:
6201:
6200:
6199:
6195:
6191:
6188:
6186:
6183:
6181:
6178:
6176:
6175:Muromonab-CD3
6173:
6172:
6171:
6170:
6166:
6165:
6163:
6157:
6149:
6146:
6145:
6144:
6143:
6139:
6138:
6133:
6130:
6128:
6125:
6124:
6123:
6122:
6118:
6114:
6110:
6109:
6104:
6101:
6100:
6099:
6098:
6094:
6093:
6088:
6085:
6084:
6083:
6082:
6078:
6077:
6072:
6069:
6068:
6067:
6066:
6062:
6061:
6056:
6053:
6052:
6051:
6050:
6049:Interleukin 5
6046:
6045:
6040:
6037:
6035:
6032:
6030:
6029:Tildrakizumab
6027:
6025:
6022:
6020:
6017:
6015:
6012:
6010:
6007:
6005:
6002:
6000:
5997:
5995:
5992:
5990:
5987:
5985:
5982:
5980:
5977:
5975:
5972:
5970:
5967:
5965:
5962:
5960:
5957:
5955:
5952:
5950:
5947:
5945:
5942:
5940:
5937:
5935:
5932:
5931:
5930:
5929:
5925:
5924:
5919:
5916:
5914:
5911:
5909:
5906:
5904:
5901:
5899:
5896:
5894:
5891:
5890:
5889:
5888:
5884:
5883:
5878:
5875:
5874:
5873:
5872:
5868:
5867:
5865:
5863:(noncellular)
5859:
5856:
5854:
5850:
5847:
5845:
5841:
5838:
5836:Extracellular
5834:
5824:
5821:
5819:
5816:
5814:
5811:
5809:
5806:
5804:
5803:Ridaforolimus
5801:
5799:
5796:
5795:
5793:
5791:
5787:
5781:
5778:
5777:
5775:
5773:
5769:
5766:
5762:Intracellular
5760:
5748:
5745:
5744:
5743:
5742:
5738:
5736:
5733:
5731:
5728:
5726:
5723:
5722:
5720:
5718:
5714:
5708:
5705:
5703:
5700:
5699:
5694:
5691:
5689:
5686:
5684:
5681:
5679:
5676:
5675:
5674:
5673:
5669:
5665:
5661:
5660:
5658:
5655:
5649:
5645:
5637:
5634:
5633:
5632:
5631:
5627:
5626:
5621:
5620:Teriflunomide
5618:
5616:
5613:
5612:
5610:
5609:
5605:
5604:
5599:
5596:
5594:
5591:
5590:
5589:
5588:
5584:
5583:
5581:
5579:
5575:
5572:
5568:Intracellular
5566:
5561:
5557:
5553:
5546:
5541:
5539:
5534:
5532:
5527:
5526:
5523:
5507:
5505:
5502:
5501:
5499:
5496:
5493:
5490:
5488:
5485:
5484:
5480:
5470:
5467:
5465:
5462:
5460:
5457:
5455:
5452:
5450:
5447:
5445:
5442:
5440:
5437:
5435:
5432:
5430:
5427:
5425:
5422:
5420:
5417:
5415:
5412:
5410:
5407:
5405:
5402:
5400:
5397:
5395:
5392:
5389:
5386:
5384:
5380:
5379:
5375:
5373:
5372:Tabelecleucel
5370:
5368:
5365:
5363:
5360:
5358:
5355:
5353:
5350:
5348:
5345:
5343:
5340:
5338:
5335:
5333:
5332:Lurbinectedin
5330:
5328:
5325:
5323:
5320:
5318:
5315:
5313:
5310:
5308:
5305:
5303:
5300:
5298:
5295:
5293:
5290:
5288:
5285:
5283:
5280:
5278:
5275:
5273:
5270:
5268:
5265:
5263:
5260:
5258:
5255:
5253:
5250:
5248:
5245:
5243:
5240:
5238:
5235:
5233:
5230:
5228:
5225:
5223:
5220:
5218:
5215:
5212:
5208:
5204:
5203:
5199:
5197:
5194:
5192:
5189:
5187:
5184:
5183:
5181:
5177:
5170:
5166:
5165:
5161:
5158:
5154:
5153:
5149:
5146:
5142:
5141:
5137:
5136:
5134:
5132:
5128:
5121:
5118:
5116:
5113:
5111:
5108:
5106:
5103:
5101:
5097:
5095:
5091:
5088:
5085:
5083:
5080:
5078:
5075:
5073:
5070:
5068:
5064:
5063:
5059:
5056:
5053:
5051:
5048:
5046:
5043:
5040:
5038:
5034:
5033:
5029:
5026:
5022:
5021:
5017:
5014:
5010:
5009:
5005:
5002:
4998:
4997:
4993:
4989:
4986:
4984:
4981:
4979:
4976:
4974:
4971:
4970:
4969:
4968:
4964:
4961:
4958:
4956:
4953:
4951:
4948:
4946:
4943:
4941:
4937:
4936:
4933:
4929:
4926:
4922:
4921:
4917:
4916:
4914:
4912:
4908:
4905:
4901:
4894:
4891:
4889:
4886:
4884:
4881:
4879:
4875:
4874:
4870:
4868:
4865:
4863:
4860:
4858:
4855:
4853:
4850:
4849:
4847:
4845:
4841:
4837:
4822:
4819:
4817:
4814:
4812:
4809:
4807:
4803:
4800:
4799:
4797:
4795:
4794:Intercalation
4791:
4784:
4781:
4779:
4776:
4774:
4770:
4769:
4765:
4763:
4760:
4758:
4755:
4753:
4750:
4747:
4743:
4742:
4738:
4736:
4733:
4732:
4730:
4728:
4724:
4718:
4715:
4713:
4710:
4708:
4705:
4703:
4702:Dicycloplatin
4700:
4698:
4695:
4693:
4690:
4689:
4687:
4685:
4681:
4675:
4672:
4670:
4667:
4665:
4662:
4660:
4657:
4655:
4651:
4650:
4646:
4643:
4641:
4637:
4634:
4632:
4628:
4627:
4624:
4621:
4619:
4616:
4614:
4611:
4608:
4604:
4601:
4599:
4596:
4594:
4591:
4589:
4585:
4584:
4581:
4578:
4576:
4575:Prednimustine
4573:
4570:
4566:
4563:
4561:
4558:
4555:
4552:
4550:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4527:
4526:
4524:
4522:
4518:
4515:
4512:
4507:
4503:
4493:
4490:
4488:
4485:
4483:
4480:
4478:
4475:
4472:
4469:
4467:
4464:
4462:
4458:
4457:
4453:
4450:
4447:
4445:
4442:
4440:
4437:
4435:
4432:
4430:
4427:
4425:
4422:
4419:
4415:
4412:
4410:
4407:
4405:
4401:
4400:
4396:
4395:
4393:
4391:
4390:Intercalation
4387:
4383:
4376:
4373:
4371:
4367:
4366:
4362:
4361:
4359:
4357:
4353:
4346:
4343:
4341:
4338:
4336:
4333:
4331:
4328:
4326:
4323:
4321:
4318:
4316:
4313:
4311:
4308:
4306:
4303:
4301:
4298:
4296:
4292:
4291:
4287:
4286:
4284:
4282:
4278:
4275:
4272:
4267:
4263:
4252:
4248:
4247:
4243:
4242:
4240:
4238:
4234:
4227:
4224:
4222:
4218:
4217:
4213:
4212:
4208:
4204:
4203:
4199:
4198:
4194:
4193:+daunorubicin
4191:
4187:
4186:
4182:
4181:
4177:
4173:
4170:
4168:
4165:
4163:
4160:
4158:
4157:Doxifluridine
4155:
4153:
4150:
4148:
4144:
4143:
4139:
4138:
4136:
4134:
4130:
4123:
4120:
4118:
4114:
4113:
4109:
4107:
4106:Rabacfosadine
4104:
4102:
4099:
4096:
4093:
4091:
4088:
4086:
4082:
4081:
4077:
4073:
4072:
4068:
4064:
4063:
4059:
4058:
4056:
4054:
4050:
4043:
4040:
4038:
4034:
4033:
4029:
4026:
4023:
4021:
4018:
4016:
4013:
4011:
4007:
4006:
4002:
4001:
3999:
3997:
3993:
3990:
3987:
3982:
3976:
3973:
3969:
3965:
3954:
3950:
3949:
3945:
3942:
3939:
3937:
3934:
3932:
3929:
3927:
3924:
3922:
3919:
3917:
3913:
3912:
3908:
3907:
3905:
3901:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3874:
3870:
3869:
3865:
3864:
3862:
3859:
3854:
3851:
3848:
3843:
3839:
3835:
3830:
3826:
3822:
3814:
3809:
3807:
3802:
3800:
3795:
3794:
3791:
3784:
3781:
3780:
3776:
3767:
3763:
3758:
3753:
3749:
3745:
3741:
3734:
3731:
3726:
3722:
3718:
3714:
3707:
3704:
3699:
3695:
3691:
3687:
3683:
3679:
3675:
3671:
3664:
3661:
3656:
3652:
3647:
3642:
3639:(4): 211–40.
3638:
3634:
3630:
3623:
3620:
3615:
3611:
3607:
3603:
3600:(3): 157–67.
3599:
3595:
3588:
3585:
3580:
3574:
3570:
3566:
3559:
3556:
3551:
3547:
3543:
3539:
3535:
3531:
3526:
3521:
3517:
3513:
3505:
3502:
3497:
3493:
3489:
3485:
3482:(5): 338–43.
3481:
3477:
3469:
3466:
3461:
3457:
3452:
3447:
3444:(3): 249–55.
3443:
3439:
3435:
3428:
3425:
3420:
3416:
3411:
3406:
3402:
3398:
3394:
3387:
3384:
3379:
3375:
3370:
3365:
3360:
3355:
3351:
3347:
3343:
3339:
3335:
3328:
3326:
3324:
3322:
3318:
3305:
3301:
3294:
3292:
3290:
3288:
3286:
3284:
3282:
3278:
3273:
3269:
3265:
3261:
3257:
3253:
3249:
3245:
3238:
3236:
3232:
3227:
3223:
3219:
3215:
3211:
3207:
3200:
3197:
3192:
3188:
3183:
3178:
3174:
3170:
3166:
3162:
3158:
3151:
3148:
3143:
3139:
3135:
3131:
3124:
3121:
3116:
3112:
3107:
3102:
3097:
3092:
3088:
3084:
3080:
3073:
3070:
3065:
3061:
3057:
3053:
3049:
3045:
3041:
3037:
3030:
3027:
3015:
3011:
3005:
3002:
2990:
2986:
2980:
2977:
2972:
2968:
2963:
2958:
2955:(4): 309–19.
2954:
2950:
2946:
2939:
2936:
2931:
2927:
2923:
2917:
2914:
2909:
2905:
2901:
2897:
2893:
2889:
2881:
2878:
2873:
2869:
2864:
2859:
2855:
2851:
2847:
2840:
2837:
2833:
2829:
2825:
2821:
2817:
2813:
2809:
2805:
2801:
2794:
2791:
2786:
2782:
2777:
2772:
2768:
2764:
2760:
2756:
2752:
2745:
2742:
2737:
2733:
2728:
2723:
2719:
2715:
2711:
2707:
2703:
2696:
2693:
2688:
2684:
2679:
2674:
2670:
2666:
2663:(3): 149–57.
2662:
2658:
2654:
2647:
2644:
2639:
2635:
2630:
2625:
2621:
2617:
2613:
2606:
2603:
2591:
2587:
2581:
2578:
2573:
2569:
2565:
2561:
2557:
2549:
2546:
2541:
2537:
2533:
2529:
2526:(2): 328–46.
2525:
2521:
2514:
2511:
2506:
2502:
2498:
2494:
2490:
2486:
2483:(2): 163–72.
2482:
2478:
2471:
2468:
2463:
2459:
2454:
2449:
2445:
2441:
2437:
2433:
2429:
2422:
2419:
2407:
2403:
2397:
2395:
2391:
2386:
2380:
2375:
2374:
2365:
2362:
2357:
2351:
2347:
2340:
2338:
2336:
2332:
2327:
2323:
2319:
2315:
2311:
2307:
2303:
2299:
2298:Rheumatol Int
2295:
2288:
2285:
2280:
2276:
2271:
2266:
2262:
2258:
2254:
2250:
2246:
2239:
2236:
2231:
2227:
2223:
2222:
2214:
2212:
2208:
2203:
2199:
2194:
2189:
2184:
2179:
2175:
2171:
2167:
2160:
2157:
2145:
2141:
2135:
2133:
2129:
2117:
2113:
2107:
2104:
2091:
2087:
2083:
2077:
2074:
2068:
2063:
2059:
2055:
2049:
2046:
2040:
2035:
2031:
2027:
2021:
2018:
2005:
2004:
2003:The Economist
1999:
1993:
1990:
1985:
1981:
1979:9780470015520
1975:
1971:
1970:
1962:
1959:
1954:
1950:
1946:
1942:
1938:
1934:
1930:
1926:
1919:
1917:
1913:
1900:
1896:
1892:
1886:
1884:
1882:
1880:
1878:
1874:
1861:
1857:
1851:
1848:
1836:
1832:
1828:
1822:
1819:
1806:
1802:
1798:
1792:
1790:
1788:
1786:
1784:
1782:
1780:
1778:
1776:
1774:
1772:
1770:
1768:
1766:
1764:
1762:
1760:
1758:
1756:
1754:
1752:
1750:
1748:
1744:
1739:
1738:
1733:
1727:
1724:
1719:
1718:
1713:
1707:
1704:
1691:
1687:
1683:
1677:
1674:
1667:
1665:
1663:
1659:
1658:chorioadenoma
1655:
1651:
1647:
1643:
1639:
1634:
1632:
1627:
1623:
1619:
1615:
1612:developed by
1611:
1607:
1604:, a chemical
1603:
1599:
1598:Sidney Farber
1590:
1585:
1577:
1575:
1573:
1569:
1564:
1561:; increasing
1560:
1556:
1552:
1548:
1544:
1538:
1536:
1532:
1528:
1524:
1520:
1516:
1512:
1511:DNA synthesis
1508:
1505:
1501:
1499:
1494:
1490:
1489:dihydrofolate
1486:
1482:
1478:
1474:
1470:
1461:
1453:
1446:
1444:
1442:
1438:
1437:colestyramine
1434:
1430:
1427:
1423:
1419:
1415:
1413:
1412:Nitrous oxide
1409:
1405:
1400:
1398:
1394:
1390:
1386:
1382:
1379:
1375:
1368:
1366:
1364:
1360:
1355:
1353:
1349:
1345:
1341:
1336:
1334:
1330:
1325:
1323:
1318:
1316:
1312:
1308:
1304:
1300:
1296:
1292:
1288:
1280:
1278:
1276:
1272:
1270:
1266:
1262:
1258:
1254:
1250:
1246:
1245:intramuscular
1238:
1236:
1234:
1230:
1226:
1222:
1218:
1214:
1213:abortifacient
1206:
1204:
1202:
1194:
1192:
1190:
1186:
1181:
1179:
1175:
1170:
1168:
1164:
1160:
1155:
1153:
1149:
1143:
1141:
1137:
1133:
1129:
1124:
1120:
1118:
1114:
1110:
1106:
1102:
1098:
1094:
1090:
1086:
1082:
1078:
1074:
1070:
1066:
1062:
1057:
1051:
1049:
1047:
1043:
1039:
1035:
1031:
1023:
1018:
1016:
1010:
1006:
1000:
998:
994:
990:
989:breastfeeding
986:
982:
981:liver disease
978:
974:
969:
967:
963:
959:
955:
951:
947:
943:
939:
935:
931:
930:breast cancer
927:
923:
919:
915:
911:
907:
903:
893:
886:
877:
872:
868:
861:
852:
848:
841:
834:
830:
829:
827:
824:
819:
812:
810:
806:
779:
777:
773:
768:
764:
760:
757:
755:
753:ECHA InfoCard
749:
741:
737:
736:DTXSID4020822
733:
732:
730:
721:
717:
709:
708:RCSB PDB
703:
698:
697:
695:
693:
689:
682:
678:
677:
675:
673:
669:
662:
658:
657:
655:
653:
649:
642:
638:
637:
635:
633:
629:
622:
618:
617:
615:
613:
609:
602:
598:
597:
595:
593:
589:
582:
578:
577:
575:
573:
569:
562:
558:
557:
555:
553:
549:
542:
538:
537:
535:
528:
524:
517:
513:
512:
510:
508:
504:
496:
491:
487:
480:
475:
471:
469:
465:
461:
459:
452:
448:
445:
443:
439:
435:
433:
429:
425:
423:
419:
415:
411:
404:
402: Rx-only
395:
392:
380:
377:
367:
365:
356:
353:
343:
342:
340:
338:
334:
329:
321:
316:
311:
306:
303:
302:
300:
298:
294:
291:
287:
283:
282:intramuscular
279:
275:
272:
270:
264:
258:
249:
248:
246:
244:
238:
231:
226:
217:
216:
214:
212:
208:
204:
200:
198:
194:
190:
186:
184:
180:
176:
172:
168:
164:
162:
158:
150:
143:
72:
70:Pronunciation
68:
65:Clinical data
63:
59:
54:
50:
45:
37:
33:
19:
9194:Orphan drugs
9189:Nephrotoxins
9164:Hepatotoxins
9149:Chemotherapy
9088:
9087:
9072:Chrysophanol
9068:
9012:Hypoxanthine
8933:
8913:
8909:Pralatrexate
8894:Methotrexate
8893:
8889:Azathioprine
8868:Topiroxostat
8845:
8816:Myo-inositol
8803:
8794:Caffeic acid
8707:Progesterone
8677:Dipyridamole
8657:Barbiturates
8634:Progesterone
8416:AR-C 69931MX
8411:AR-C 67085MX
8383:Antagonists:
8382:
8236:AR-C 67085MX
8182:
8151:
8129:
8123:
8086:
8053:Oxidized-ATP
7998:JNJ-47965567
7959:
7883:Antagonists:
7882:
7856:L-β,γ-Me-ATP
7836:D-β,γ-Me-ATP
7772:
7709:Theophylline
7619:Paraxanthine
7564:Fenethylline
7554:Enprofylline
7519:Ciforadenant
7441:Antagonists:
7440:
7404:Piclidenoson
7386:
7298:
7282:2-Cl-IB-MECA
7274:
7269:
7237:
7117:Azathioprine
7110:
7105:Methotrexate
7104:
7098:
6952:Upadacitinib
6912:Satralizumab
6897:Ritlecitinib
6892:Risankizumab
6687:
6668:
6608:Teprotumumab
6558:Inebilizumab
6553:Fontolizumab
6533:Atorolimumab
6501:T-lymphocyte
6499:
6473:
6457:
6443:
6424:
6413:Lerdelimumab
6408:Bertilimumab
6400:
6388:
6367:
6353:
6339:
6325:
6306:
6287:
6271:Pascolizumab
6256:Obinutuzumab
6248:
6234:
6220:
6204:Clenoliximab
6196:
6180:Otelixizumab
6167:
6140:
6127:Lebrikizumab
6111:
6095:
6079:
6063:
6047:
6004:Satralizumab
5994:Risankizumab
5926:
5885:
5869:
5861:Serum target
5813:Temsirolimus
5739:
5730:Pomalidomide
5725:Lenalidomide
5683:Pimecrolimus
5662:
5636:Methotrexate
5635:
5628:
5606:
5593:Azathioprine
5585:
5570:(initiation)
5419:Tazemetostat
5383:Alitretinoin
5376:
5287:Estramustine
5267:Elsamitrucin
5257:Eflornithine
5211:Pegaspargase
5207:Asparaginase
5200:
5169:Testolactone
5162:
5150:
5138:
5092:
5077:Panobinostat
5060:
5030:
5018:
5006:
4994:
4965:
4930:
4918:
4871:
4867:Padeliporfin
4806:Dactinomycin
4802:Streptomyces
4783:Temozolomide
4778:Mitozolomide
4766:
4757:Mitobronitol
4746:Procarbazine
4739:
4727:Nonclassical
4652:
4629:
4623:Streptozocin
4588:Nitrosoureas
4586:
4560:Chlorambucil
4554:Trofosfamide
4540:Chlormethine
4535:Bendamustine
4528:
4466:Mitoxantrone
4461:Losoxantrone
4454:
4414:Daunorubicin
4397:
4363:
4300:Camptothecin
4288:
4244:
4214:
4200:
4183:
4167:Fluorouracil
4147:Capecitabine
4140:
4110:
4074:
4060:
4030:
4025:Pralatrexate
4015:Methotrexate
4014:
4003:
3946:
3909:
3866:
3747:
3743:
3733:
3716:
3712:
3706:
3676:(2): 361–6.
3673:
3669:
3663:
3636:
3632:
3622:
3597:
3593:
3587:
3569:Methotrexate
3568:
3558:
3515:
3511:
3504:
3479:
3475:
3468:
3441:
3438:Rheumatology
3437:
3427:
3403:(4): 340–1.
3400:
3396:
3386:
3341:
3337:
3308:. Retrieved
3303:
3247:
3243:
3209:
3205:
3199:
3164:
3161:Rheumatology
3160:
3150:
3133:
3129:
3123:
3086:
3082:
3072:
3039:
3035:
3029:
3017:. Retrieved
3013:
3004:
2992:. Retrieved
2988:
2979:
2952:
2948:
2938:
2916:
2891:
2887:
2880:
2853:
2849:
2839:
2831:
2803:
2799:
2793:
2758:
2754:
2744:
2709:
2705:
2695:
2660:
2656:
2646:
2619:
2615:
2605:
2593:. Retrieved
2589:
2580:
2555:
2548:
2523:
2519:
2513:
2480:
2476:
2470:
2435:
2431:
2421:
2409:. Retrieved
2405:
2372:
2364:
2345:
2304:(2): 59–62.
2301:
2297:
2287:
2252:
2248:
2238:
2220:
2173:
2169:
2159:
2147:. Retrieved
2143:
2119:. Retrieved
2115:
2106:
2094:. Retrieved
2085:
2076:
2067:10665/345533
2057:
2048:
2039:10665/325771
2029:
2020:
2010:16 September
2008:. Retrieved
2001:
1992:
1968:
1961:
1931:(1): 25–50.
1928:
1924:
1903:. Retrieved
1894:
1864:. Retrieved
1859:
1850:
1838:. Retrieved
1830:
1821:
1809:. Retrieved
1800:
1735:
1726:
1715:
1706:
1694:. Retrieved
1690:the original
1676:
1642:solid tumors
1635:
1595:
1572:anticytokine
1539:
1531:thymidylates
1498:de novo
1497:
1466:
1416:
1404:cyclosporins
1401:
1397:trimethoprim
1372:
1356:
1348:myelopathies
1337:
1326:
1319:
1284:
1273:
1253:subcutaneous
1242:
1210:
1198:
1182:
1171:
1156:
1144:
1125:
1121:
1058:
1055:
1030:chemotherapy
1027:
1024:Chemotherapy
1019:Medical uses
1001:
985:lung disease
970:
950:osteosarcoma
906:amethopterin
905:
902:Methotrexate
901:
900:
889:
494:
455:Elimination
337:Legal status
331:Legal status
286:subcutaneous
230:Methotrexate
211:License data
41:Methotrexate
36:
18:Amethopterin
9134:Antifolates
8934:Precursors:
8914:Many others
8884:Aminopterin
8841:Phytic acid
8784:Amflutizole
8779:Allopurinol
8735:Decynium-22
8692:Hexobendine
8564:Transporter
8541:Ticlopidine
8446:Clopidogrel
8356:UDP-glucose
8095:Purotoxin 1
7926:AZ-11645373
7921:AZ-10606120
7719:Tracazolate
7699:Theobromine
7684:SCH-442,416
7679:Rolofylline
7629:Preladenant
7499:Cartazolate
7479:Bamifylline
7429:Tecadenoson
7424:Sonedenoson
7419:Selodenoson
7414:SDZ WAG 994
7409:Regadenoson
7394:Namodenoson
7346:Capadenoson
7341:Binodenoson
7336:BAY 60–6583
7139:from market
7088:Leflunomide
7079:Chloroquine
7074:Bucillamine
7054:Aurotioprol
6947:Tofacitinib
6887:Ravulizumab
6877:Pirfenidone
6867:Peficitinib
6767:Canakinumab
6757:Briakinumab
6747:Bimekizumab
6742:Baricitinib
6707:Aflibercept
6618:Vepalimomab
6613:Vapaliximab
6588:Rovelizumab
6578:Pexelizumab
6568:Morolimumab
6543:Cedelizumab
6528:Anifrolumab
6523:Alemtuzumab
6481:Basiliximab
6451:Tocilizumab
6437:Vedolizumab
6432:Natalizumab
6418:Metelimumab
6361:Gavilimomab
6319:Toralizumab
6314:Teneliximab
6300:Lumiliximab
6295:Gomiliximab
6281:Ublituximab
6261:Ocrelizumab
6214:Zanolimumab
6190:Visilizumab
6148:Secukinumab
6132:Ustekinumab
6103:Elsilimomab
6087:Faralimomab
6055:Mepolizumab
6039:Ustekinumab
6034:Tocilizumab
6009:Secukinumab
5959:Canakinumab
5949:Briakinumab
5944:Bimekizumab
5939:Basiliximab
5928:Interleukin
5918:Nerelimomab
5823:Zotarolimus
5764:(reception)
5735:Thalidomide
5693:Voclosporin
5678:Ciclosporin
5672:Calcineurin
5668:Cyclophilin
5615:Leflunomide
5611:inhibitors
5494:from market
5464:Vorasidenib
5444:Trabectedin
5429:Tiazofurine
5424:Tebentafusp
5409:Tagraxofusp
5367:Plitidepsin
5337:Mitoguazone
5277:Epacadostat
5247:Demecolcine
5191:Aflibercept
5164:Sex steroid
5037:Fuzuloparib
4978:Carfilzomib
4950:Palbociclib
4940:Abemaciclib
4893:Verteporfin
4857:Efaproxiral
4773:Dacarbazine
4735:Altretamine
4717:Satraplatin
4712:Oxaliplatin
4692:Carboplatin
4669:Triaziquone
4640:Mannosulfan
4618:Ranimustine
4598:Fotemustine
4439:Pirarubicin
4424:Doxorubicin
4418:+cytarabine
4404:Aclarubicin
4365:Podophyllum
4290:Camptotheca
4221:Azacitidine
4207:Gemcitabine
4162:Floxuridine
4095:Fludarabine
4090:Clofarabine
4076:Halogenated
4067:Pentostatin
4042:Raltitrexed
4010:Aminopterin
3953:Ixabepilone
3948:Epothilones
3916:Cabazitaxel
3893:Vinorelbine
3878:Vincristine
3873:Vinblastine
3858:microtubule
3250:(8): 42–5.
3019:19 February
2989:Mayo Clinic
2595:19 February
2411:19 February
2149:19 February
1650:Min Chiu Li
1602:aminopterin
1479:(DHFR), an
1385:paromomycin
1374:Penicillins
1363:chemo brain
1329:teratogenic
1307:pneumonitis
1257:intrathecal
1249:intravenous
1233:misoprostol
1136:paracetamol
1093:sarcoidosis
938:lung cancer
816: g·mol
759:100.000.376
681:ChEMBL34259
661:CHEBI:44185
477:Identifiers
290:intrathecal
278:intravenous
197:MedlinePlus
170:Other names
161:Trade names
32:Aminopterin
9144:Benzamides
9128:Categories
8904:Pemetrexed
8863:Tisopurine
8836:Oxipurinol
8831:Niraxostat
8821:Kaempferol
8811:Febuxostat
8755:inhibitors
8667:Cilostazol
8629:Phloridzin
8536:Ticagrelor
8406:AR-C 66096
8266:Diquafosol
8211:α,β-Me-ATP
8196:2-Thio-UTP
8105:Ro 0437626
8058:Phenol Red
7973:Gefapixant
7968:Evans blue
7851:Ivermectin
7781:α,β-Me-ATP
7744:nucleotide
7729:ZM-241,385
7714:Tozadenant
7589:MRE3008F20
7549:Dyphylline
7534:Dimethazan
7464:Acefylline
7434:UK-432,097
7366:Evodenoson
7361:CP-532,903
7321:Apadenoson
7200:modulators
7112:thiopurine
7100:antifolate
7008:Quinolines
6937:Sutimlimab
6932:Spesolimab
6917:Siltuximab
6857:Olokizumab
6847:Ixekizumab
6842:Itacitinib
6832:Guselkumab
6827:Fingolimod
6822:Filgotinib
6772:Crovalimab
6762:Brodalumab
6752:Blisibimod
6717:Rilonacept
6700:Opinercept
6695:Etanercept
6681:Belatacept
6632:Polyclonal
6593:Siplizumab
6583:Reslizumab
6573:Ofatumumab
6563:Maslimomab
6548:Emapalumab
6491:Inolimomab
6486:Daclizumab
6465:Odulimomab
6380:Ruplizumab
6375:Frexalimab
6333:Aselizumab
6228:Efalizumab
6185:Teplizumab
6081:Interferon
6071:Omalizumab
6024:Spesolimab
6014:Siltuximab
5989:Rilonacept
5984:Olokizumab
5974:Ixekizumab
5969:Guselkumab
5964:Daclizumab
5954:Brodalumab
5913:Infliximab
5898:Afelimomab
5893:Adalimumab
5877:Eculizumab
5853:Monoclonal
5844:Antibodies
5818:Umirolimus
5798:Everolimus
5747:Apremilast
5707:Gusperimus
5688:Tacrolimus
5656:inhibitors
5648:Macrolides
5630:antifolate
5459:Verdinexor
5454:Venetoclax
5357:Oblimersen
5352:Navitoclax
5327:Lucanthone
5322:Lonidamine
5312:Lifileucel
5307:Ivosidenib
5302:Imetelstat
5272:Enasidenib
5262:Elesclomol
5227:Bexarotene
5222:Belzutifan
5157:Bexarotene
5145:Atrasentan
5120:Umbralisib
5115:Idelalisib
5105:Copanlisib
5087:Vorinostat
5082:Romidepsin
5072:Entinostat
5067:Belinostat
5025:Masoprocol
5013:Tiazofurin
5001:Anagrelide
4973:Bortezomib
4960:Seliciclib
4955:Ribociclib
4935:inhibitors
4925:Tipifarnib
4888:Temoporfin
4883:Talaporfin
4821:Plicamycin
4816:Mitomycins
4762:Pipobroman
4741:Hydrazines
4707:Nedaplatin
4659:Carboquone
4654:Aziridines
4645:Treosulfan
4593:Carmustine
4580:Uramustine
4549:Ifosfamide
4521:Alkylating
4482:Bisantrene
4471:Pixantrone
4444:Valrubicin
4434:Idarubicin
4429:Epirubicin
4375:Teniposide
4330:Lurtotecan
4325:Irinotecan
4226:Decitabine
4190:Cytarabine
4133:Pyrimidine
4122:Tioguanine
4112:Thiopurine
4101:Nelarabine
4085:Cladribine
4037:Pemetrexed
4020:Pemetrexed
3996:Folic acid
3936:Paclitaxel
3888:Vinflunine
2176:(2): 273.
2121:14 January
2096:14 January
1840:22 October
1696:20 January
1668:References
1610:folic acid
1582:See also:
1519:pyrimidine
1504:nucleoside
1473:antifolate
1441:dantrolene
1422:omeprazole
1389:Probenecid
1295:leukopenia
1291:stomatitis
1275:Folic acid
1269:creatinine
1203:(eczema).
1101:vasculitis
1040:and other
997:folic acid
821:3D model (
809:Molar mass
692:PDB ligand
621:YL5FZ2Y5U1
592:ChemSpider
552:IUPHAR/BPS
507:CAS Number
486:IUPAC name
442:Metabolism
9089:See also:
8992:Guanosine
8942:Adenosine
8858:Quercetin
8826:Myricetin
8682:Estradiol
8609:Estradiol
8599:Adenosine
8511:Prasugrel
8451:Elinogrel
8441:Cangrelor
8386:2-Me-SAMP
8326:PAPET-ATP
8286:INS-37217
8261:Denufosol
8216:Adenosine
8206:5-OMe-UDP
8191:2-Me-SATP
8186:2-Me-SADP
8183:Agonists:
8078:PSB-12062
8013:Magnesium
7978:GW-791343
7866:PAPET-ATP
7786:Adenosine
7776:2-Me-SATP
7773:Agonists:
7694:Theacrine
7689:SCH-58261
7674:Reversine
7559:Etazolate
7509:CGS-15943
7484:Cafedrine
7356:CGS-21680
7306:Adenosine
7287:2'-MeCCPA
7270:Agonists:
7261:adenosine
7238:Agonists:
7149:Phase III
7137:Withdrawn
7044:Auranofin
6993:Specific
6927:Sirukumab
6922:Siponimod
6907:Sarilumab
6882:Ponesimod
6852:Netakimab
6837:Iptacopan
6817:Etrasimod
6777:Danicopan
6712:Alefacept
6676:Abatacept
6598:Talizumab
6538:Begelomab
6394:Belimumab
6347:Galiximab
6276:Rituximab
6242:Erlizumab
6209:Keliximab
6019:Sirukumab
5999:Sarilumab
5979:Netakimab
5908:Golimumab
5808:Sirolimus
5504:Phase III
5492:Withdrawn
5469:Vosaroxin
5449:Veliparib
5404:Sotorasib
5394:Selinexor
5388:Tretinoin
5378:Retinoids
5292:Glasdegib
5237:Celecoxib
5186:Adagrasib
5110:Duvelisib
5100:Alpelisib
5055:Rucaparib
5042:Niraparib
4983:Oprozomib
4945:Alvocidib
4811:Bleomycin
4768:Triazenes
4752:Etoglucid
4697:Cisplatin
4613:Nimustine
4607:Semustine
4603:Lomustine
4565:Melphalan
4492:Menogaril
4487:Crisnatol
4477:Amsacrine
4449:Zorubicin
4409:Amrubicin
4370:Etoposide
4345:Topotecan
4340:Silatecan
4335:Rubitecan
4320:Gimatecan
4305:Cositecan
4295:Belotecan
3971:inhibitor
3941:Tesetaxel
3931:Ortataxel
3926:Larotaxel
3921:Docetaxel
3883:Vindesine
3719:: 11–20.
3520:CiteSeerX
3212:(7): 15.
2622:: 16–25.
1897:. WebMD.
1811:22 August
1636:In 1951,
1618:remission
1547:adenosine
1507:thymidine
1500:synthesis
1433:cisplatin
1429:valproate
1393:retinoids
1315:mucositis
1165:or other
1065:psoriasis
954:psoriasis
468:Excretion
457:half-life
267:Routes of
241:Pregnancy
189:Monograph
183:Drugs.com
9118:Medicine
8967:Cytidine
8962:Cytosine
8853:Propolis
8619:KGO-2173
8614:KGO-2142
8604:dMeThPmR
8570:blockers
8526:Regrelor
8516:PSB-0739
8486:MRS-2578
8481:MRS-2500
8476:MRS-2395
8471:MRS-2279
8466:MRS-2211
8461:MRS-2179
8336:PSB-1114
8331:PSB-0474
8316:MRS-4062
8311:MRS-2957
8306:MRS-2768
8301:MRS-2693
8296:MRS-2690
8291:MRS-2365
8201:5-Br-UDP
8143:TC-P 262
8083:Puerarin
8018:MRS-2159
7993:isoPPADS
7911:A-839977
7906:A-804598
7901:A-740003
7896:A-438079
7891:A-317491
7861:MRS-2219
7724:VUF-5574
7669:PSB-1115
7614:MRS-3777
7609:MRS-1754
7604:MRS-1706
7599:MRS-1334
7594:MRS-1220
7584:KF-26777
7529:CVT-6883
7504:CGH-2466
7489:Caffeine
7381:LUF-5845
7376:LUF-5835
7371:GR 79236
7326:ATL-146e
7208:Receptor
6862:Ozanimod
6737:Avacopan
6730:Unsorted
6516:Unsorted
6426:Integrin
6159:Cellular
5934:Anakinra
5780:Anakinra
5702:Abetimus
5554: /
5342:Mitotane
5282:Eribulin
5050:Olaparib
4988:Ixazomib
4664:Thiotepa
4636:Busulfan
4315:Exatecan
4152:Carmofur
3860:assembly
3823: /
3766:14202592
3725:13786791
3698:22939197
3690:13379512
3655:14850976
3614:14777272
3550:25311594
3496:15194170
3460:18045808
3419:10476546
3378:12359872
3310:12 April
3264:19633502
3226:17459301
3191:36318965
3182:10070067
3142:21044438
3115:31709258
2971:18522946
2908:37722926
2872:36949024
2828:36049926
2820:26479437
2785:26981630
2736:31388915
2687:22850632
2638:23874006
2572:22071858
2540:11840435
2497:15914465
2462:24916606
2326:25311594
2279:23295701
2230:30199187
2202:38254764
2193:10813957
2116:ClinCalc
2090:Archived
2086:ClinCalc
2056:(2021).
2028:(2019).
1984:Archived
1953:46974070
1905:12 April
1899:Archived
1805:Archived
1606:analogue
1535:proteins
1424:and the
1420:such as
1381:neomycin
1163:anti-TNF
1130:such as
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942:lymphoma
934:leukemia
892:(verify)
572:DrugBank
297:ATC code
274:By mouth
243:category
225:DailyMed
9159:Folates
9076:rhubarb
9069:Others:
9047:Uridine
9017:Inosine
8987:Guanine
8937:Adenine
8687:Ethanol
8672:Dilazep
8624:MeThPmR
8531:Suramin
8436:C1330-7
8281:INS-365
8160:TNP-ATP
8138:Suramin
7936:Calcium
7664:PSB-788
7659:PSB-603
7474:ATL-444
7246:Adenine
7229:adenine
7214:ligands
6658:-cept (
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4172:Tegafur
3986:S phase
3911:Taxanes
3847:M phase
3646:2616951
3542:8292668
3346:Bibcode
3272:9456346
3244:Nursing
3106:6819370
3089:: 238.
3064:6273303
2994:10 July
2776:4820247
2727:6816735
2678:3400102
2629:3715949
2505:1643606
2453:7047041
2318:9782534
2270:4629813
2170:Cancers
1945:7510620
1866:25 June
1600:showed
1578:History
1559:B cells
1502:of the
1471:of the
1299:anaemia
1152:strokes
1132:aspirin
1113:uveitis
908:, is a
814:454.447
776:Formula
581:DB00563
527:PubChem
516:59-05-2
447:Hepatic
393:Rx-only
390:WARNING
362::
317: (
315:L04AX03
313:)
307: (
305:L01BA01
256: D
227::
203:a682019
9104:Portal
9042:Uracil
9037:Ribose
8927:Others
8877:Others
8749:Enzyme
8496:NF-340
8491:NF-157
8391:A3P5PS
8321:NF-546
8043:NF-449
8038:NF-279
8033:NF-157
8028:NF-110
8023:NF-023
7956:Emodin
7951:Copper
7916:AF-353
7886:5-BDBD
7846:HT-AMP
7654:PSB-36
7649:PSB-11
7644:PSB-10
7132:WHO-EM
6670:CTLA-4
6660:Fusion
6161:target
6142:IL-17A
6119:, and
5652:other
5487:WHO-EM
5096:(Pi3K)
4053:Purine
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3744:Cancer
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1533:, and
1515:purine
1481:enzyme
1439:, and
1408:NSAIDs
1267:, and
1140:DMARDs
1128:NSAIDs
1013:
975:, and
960:, and
948:, and
924:, and
918:cancer
847:SMILES
672:ChEMBL
641:D00142
601:112728
541:126941
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374:
364:℞-only
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8697:NBMPR
8506:PPADS
8431:BzATP
8396:AMPαS
8376:UTPγS
8346:UDPβS
8246:ATPγS
8226:ADPβS
8110:Ro 51
8073:PPNDS
8068:PPADS
8008:KN-62
8003:KN-04
7821:BzATP
7816:ATPγS
7544:DPCPX
7063:Other
6459:LFA-1
6369:CD154
6222:CD11a
6121:IL-23
6117:IL-13
6113:IL-12
5717:IMiDs
5008:IMPDI
4903:Other
3694:S2CID
3546:S2CID
3268:S2CID
3060:S2CID
2824:S2CID
2501:S2CID
2322:S2CID
1949:S2CID
1925:Drugs
1255:, or
1089:lupus
867:InChI
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699:MTX (
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8723:PMAT
8645:ENTs
8582:CNTs
8521:RB-2
8456:Ip5I
8401:Ap4A
8366:Up3U
8256:dATP
8231:Ap3A
8165:Zinc
8115:RO-3
8100:RB-2
7988:Ip5I
7876:Zinc
7806:Ap5A
7801:Ap4A
7569:IBMX
7539:DMPX
7351:CCPA
6999:M01C
6389:BLyS
6341:CD80
6308:CD40
6289:CD23
6250:CD20
6236:CD18
6097:IL-6
5790:mTOR
5664:FKBP
5654:IL-2
5094:PIKI
5062:HDAC
4511:CCNS
3762:PMID
3721:PMID
3686:PMID
3651:PMID
3610:PMID
3573:ISBN
3538:PMID
3492:PMID
3456:PMID
3415:PMID
3374:PMID
3312:2014
3260:PMID
3222:PMID
3187:PMID
3138:PMID
3111:PMID
3052:PMID
3021:2023
3014:NICE
2996:2022
2967:PMID
2904:PMID
2868:PMID
2816:PMID
2781:PMID
2732:PMID
2683:PMID
2634:PMID
2597:2023
2590:NRAS
2568:PMID
2536:PMID
2493:PMID
2458:PMID
2436:2014
2413:2023
2379:ISBN
2350:ISBN
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2275:PMID
2226:PMID
2198:PMID
2151:2023
2123:2024
2098:2024
2012:2017
1974:ISBN
1941:PMID
1907:2014
1868:2024
1842:2023
1813:2016
1698:2016
1656:and
1563:CD95
1517:and
1395:and
1383:and
1350:and
1309:and
1301:and
1150:and
1115:and
1067:and
912:and
702:PDBe
632:KEGG
612:UNII
561:4815
416:data
179:AHFS
9062:UTP
9057:UDP
9052:UMP
9032:ITP
9027:IDP
9022:IMP
9007:GTP
9002:GDP
8997:GMP
8982:CTP
8977:CDP
8972:CMP
8957:ATP
8952:ADP
8947:AMP
8546:UDP
8501:PIT
8426:ATP
8371:UTP
8341:UDP
8276:ITP
8271:IDP
8251:CTP
8241:ATP
8221:ADP
8175:P2Y
7983:HMA
7931:BBG
7871:UTP
7841:GTP
7831:CTP
7811:ATP
7796:AMP
7791:ADP
7760:ATP
7754:P2X
7524:CPX
7331:ATP
7316:AMP
7311:ADP
7297:5'-
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6402:CAT
6198:CD4
6169:CD3
5887:TNF
5560:L04
5140:ERA
4996:PhI
4967:PrI
4932:CDK
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3842:MIs
3838:SPs
3829:L01
3752:doi
3678:doi
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3602:doi
3530:doi
3484:doi
3446:doi
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2957:doi
2926:doi
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2892:189
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2440:doi
2306:doi
2265:PMC
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2188:PMC
2178:doi
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2034:hdl
1933:doi
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1608:of
1527:RNA
1523:DNA
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725:EPA
531:CID
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320:WHO
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