319:
571:
epithelial cells conducted at the
Illinois Institute of Technology Research Institute (IITRI), Chicago, USA, showed a decrease in viral titers due to incubation with enisamium iodide (24 FAV00A). year on 3 log (1000 times). In addition, the polymerase chain reaction with reverse transcription revealed suppression of the expression of the M-gene of influenza virus by almost 2 orders of magnitude.
40:
593:
treatment was noted by 43.3% of patients in the main group and 15% in the control group (p <0.001). On day 7 of treatment, almost all patients (59 out of 60) who received enisamium iodide returned to their usual way of life, while 37.5% of those who took placebo continued to feel unwell and had not yet returned to normal. work and leisure.
570:
Enisamium has antiviral activity against various strains of influenza A (H1N1, H3N2, H5N1, H7N9), influenza B virus, respiratory syncytial virus, as well as strains of alpha-coronavirus NL-63 and beta-coronavirus SARS-CoV-2, etc. In vitro studies using influenza virus-infected normal human bronchial
579:
Amizon tablets are indicated for the treatment and prevention of influenza and acute respiratory viral infections. Amizon Max and
Amizonchik syrup according to the instructions for medicines are intended for the treatment of influenza and SARS. Amizon Max is also used to treat COVID-19 of moderate
592:
In the enisamium iodide group, the mean duration of fever was shown to be 2.7 days, and in the placebo group, 3.8 days. Thus, as a result of taking enisamium iodide, the duration of fever was reduced by an average of 1.1 days. When assessing well-being, a significant improvement on the 3rd day of
588:
In 2010, the third phase of clinical trials on the basis of FBDU "Research
Institute of Influenza" of the Ministry of Health of the Russian Federation (St. Petersburg, Russia) was completed with 100 patients (60 patients with influenza and SARS received enisamium iodide, 40 – placebo).
599:
From May 2020 to March 2021, a batotocent clinical placebo-controlled, double-blind, randomized trial of enisamium iodide (Amizon Max) in patients with moderate to severe COVID-19 was conducted at 14 health care facilities in
Ukraine. receiving inpatient treatment.<
781:
Holubovska O, Bojkova D, Elli S, Bechtel M, Boltz D, Muzzio M, et al. (January 2021). "Enisamium is an inhibitor of the SARS-CoV-2 RNA polymerase and shows improvement of recovery in COVID-19 patients in an interim analysis of a clinical trial".
507:. In 1997, enisamium iodide was registered as a non-narcotic analgesic and antipyretic. However, it is no longer used for these indications. Amizon is marketed as an antiviral drug for the treatment and prevention of influenza and SARS.
603:
The results of the clinical trial allowed to include in the instructions for medical use of the drug Amizon Max new indications for use, in particular - the treatment of COVID-19 moderate severity in combination with basic therapy.
561:
The antiviral activity of enisamium iodide is associated with inhibition of influenza virus RNA polymerase. Enisamium iodide effectively inhibited SARS-CoV-2 virus replication in vitro in Caco-2 cells.
758:
524:
Since 2008, the non-clinical program, which included a set of pharmacological, pharmacokinetic and toxicological studies, has been performed in several research institutes and laboratories in
622:"Амізон: інструкція по застосуванню, ціна в аптеках України, аналоги, склад, показання | Amizon таблетки, вкриті оболонкою компанії "Фармак" | Довідник лікарських препаратів Компендіум"
492:
92:
624:[Amizon: instructions for use, price in pharmacies of Ukraine, analogues, composition, indications | Amizon coated tablets "Farmak" | Directory of drugs Compendium].
504:
514:
and the
National Academy of Medical Sciences of Ukraine, Frolov was the first to demonstrate the antiviral activity of enisamium iodide in in vitro experiments.
406:
392:
833:
732:[An international research group published the results of a study on the effectiveness of the drug "Amizon" in the treatment of COVID-19].
511:
1092:
701:
426:
730:"Международная исследовательская группа обнародовала результаты исследования эффективности препарата "Амизон" в терапии COVID-19"
153:
761:[The second birth of the drug Amizon®: the results of international scientific studies confirm the antiviral effect].
503:
The compound enisamium iodide was first synthesized by scientists of the
Institute of Pharmacology and Toxicology of the
238:
967:"Enisamium Reduces Influenza Virus Shedding and Improves Patient Recovery by Inhibiting Viral RNA Polymerase Activity"
298:
1055:
Rudenko AE, Trinus FP, Korzhenevskiĭ LV, Bukhtiarova TA, Koval' AZ, Malyĭ VD, Novikova OV, Tkachenko EV (1996). "".
872:[Clinical efficacy of Amizon in the treatment of influenza and other acute respiratory viral infections.]
1082:
803:
488:
759:"Друге народження препарату Амізон®: результати міжнародних наукових досліджень підтверджують противірусну дію"
844:
679:[Universal inducer of endogenous interferon amizon in the prevention and treatment of influenza].
287:
834:"Modern Non-Steroidal Anti-Inflammatory Drug and Interferon Inductor Amizon: Prospects of Application"
783:
870:"Клиническая эффективность Амизона в терапии гриппа и других острых респираторных вирусных инфекций"
314:
173:
1030:"Клініко-експериментальна характеристика Амізону й досвід його застосування в клінічній практиці"
897:"Enisamium is a small molecule inhibitor of the influenza A virus and SARS-CoV-2 RNA polymerases"
704:[Modern approaches to the treatment of SARS. Amazon: results of international research].
495:– J05AX17 (Antivirals for systemic use of direct action) and included it in the ATC / DDD index.
965:
Te
Velthuis AJ, Zubkova TG, Shaw M, Mehle A, Boltz D, Gmeinwieser N, et al. (March 2021).
517:
Recent studies have shown that the antiviral effect of enisamium is due to inhibition of viral
1102:
1060:
996:
922:
788:
453:
55:
227:
1041:
986:
978:
912:
904:
895:
Walker AP, Fan H, Keown JR, Margitich V, Grimes JM, Fodor E, Te
Velthuis AJ (January 2020).
335:
182:
117:
247:
1097:
457:
434:
InChI=1S/C14H14N2O.HI/c1-16-9-7-13(8-10-16)14(17)15-11-12-5-3-2-4-6-12;/h2-10H,11H2,1H3;1H
125:
677:"Універсальний індуктор ендогенного інтерферону амізон у профілактиці та лікуванні грипу"
318:
1087:
1046:
1029:
991:
966:
917:
896:
533:
529:
481:
869:
841:
Institute of
Pharmacology and Toxicology of the Academy of Medical Sciences of Ukraine
1076:
545:
207:
729:
468:
is sometimes used. Enisamium iodide is a registered antiviral drug sold in
Ukraine,
649:
105:
100:
757:
Frolov AF, Golubovskaya OA, Kramarev SA, Mironenko AP, Margitich VM (2018-09-05).
510:
In 2005, Doctor of Medical Sciences, Professor, and a corresponding member of the
31:
541:
537:
39:
908:
702:"Сучасні підходи до лікування ГРВІ. Амізон: результати міжнародних досліджень"
469:
368:
218:
135:
1000:
926:
1064:
982:
868:
Melnikova TI, Deeva EG, Amosova IV, Oksamitnaya EG, Margitich VM (2013).
473:
832:
Bukhtiarova TA, Danylenko VP, Khomenko VS, Shatyrkina TV, Yadlovsky OE.
621:
525:
477:
464:-benzyl-1-methylpyridin-1-ium-4-carboxamide iodide, the shortened name
193:
17:
278:
940:
267:
391:
382:
596:
Enisamium was more effective when treatment was started earlier.
484:
countries under the trade names Amizon, Amizon Max, Amizonchik.
258:
676:
518:
303:
945:ДУ "Інститут фармакології та токсикології НАМН України"
806:[Amizon is a find of Ukrainian pharmacologists]
644:
642:
380:
367:
334:
329:
297:
277:
257:
237:
217:
192:
172:
144:
134:
124:
116:
91:
64:
54:
49:
164:-benzyl-1-methylpyridin-1-ium-4-carboxamide iodide
776:
774:
772:
724:
722:
206:
78:-Benzyl) aminocarbonyl-1-methylpyridinium iodide
505:National Academy of Medical Sciences of Ukraine
181:
752:
750:
8:
580:severity in combination with basic therapy.
30:
804:"Амизон — находка украинских фармакологов"
317:
226:
84:-Methyl-4-benzylurebamidopyridinium iodide
38:
1045:
990:
916:
787:
246:
1028:Marushko Y, Sabadash YY (October 2015).
613:
431:
411:
313:
158:
29:
1023:(Report) (in Ukrainian). 19 May 2016.
971:Antimicrobial Agents and Chemotherapy
286:
7:
671:
669:
104:
266:
197:
1047:10.22141/2224-0551.6.66.2015.74992
25:
414:C1=CC=C(C=C1)C(=O)NCC2=CC=CC=C2.
355:
346:
521:polymerase of influenza virus.
439:Key:ILSOAHPXYZRFBA-UHFFFAOYSA-N
361:
352:
340:
1:
1093:Quaternary ammonium compounds
1019:РІШЕННЯ [Decision].
763:Український медичний часопис
584:Clinical efficacy and safety
512:National Academy of Sciences
1059:(in Russian) (5–6): 134–6.
789:10.1101/2021.01.05.21249237
1119:
552:Pharmacological properties
491:assigned enisamium iodide
330:Chemical and physical data
909:10.1101/2020.04.21.053017
489:World Health Organization
422:
402:
149:
37:
458:systematic chemical name
650:"WHOCC - ATC/DDD Index"
983:10.1128/AAC.02605-20
812:www.provisor.com.ua
557:Mechanism of action
452:is a derivative of
34:
943:[Amizon].
878:Здоров'я України
734:Интерфакс-Украина
454:isonicotinic acid
447:
446:
393:Interactive image
299:CompTox Dashboard
27:Chemical compound
16:(Redirected from
1110:
1083:Drugs in Ukraine
1068:
1057:Likars'ka Sprava
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1004:
994:
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956:
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880:(in Ukrainian).
875:
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858:
856:
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849:
843:. Archived from
838:
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566:Pharmacodynamics
482:Eastern European
450:Enisamium iodide
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32:Enisamium iodide
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1012:Further reading
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948:
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850:on 14 July 2014
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631:
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501:
466:carbabenzpiride
456:. Based on its
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118:Pharmacokinetic
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71:Carbabenzpiride
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23:
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947:(in Ukrainian)
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1040:(66): 51–56.
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1034:Childs Health
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765:(in Russian).
764:
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747:
735:
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723:
719:
707:
706:health-ua.com
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546:United States
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487:In 2019, the
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288:ChEMBL1716983
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50:Clinical data
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960:
949:. Retrieved
944:
935:
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881:
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863:
852:. Retrieved
845:the original
840:
827:
816:. Retrieved
811:
798:
762:
738:. Retrieved
736:(in Russian)
733:
710:. Retrieved
705:
696:
685:. Retrieved
680:
657:. Retrieved
654:www.whocc.no
653:
630:. Retrieved
625:
616:
602:
598:
595:
591:
587:
578:
569:
560:
523:
516:
509:
502:
486:
480:, and other
465:
461:
449:
448:
161:
81:
75:
575:Medical use
542:Switzerland
538:Netherlands
376: g·mol
183:201349-37-3
145:Identifiers
65:Other names
56:Trade names
1077:Categories
951:2022-05-12
854:2022-05-12
818:2022-05-12
740:2022-05-12
712:2022-05-12
687:2022-05-12
681:m-l.com.ua
659:2022-05-12
632:2022-05-12
626:Компендіум
608:References
470:Kazakhstan
381:3D model (
369:Molar mass
248:G22FG6Q00B
219:ChemSpider
174:CAS Number
154:IUPAC name
126:Metabolism
1021:ДСІВУ АП
136:Excretion
1103:Anilides
1001:33558285
941:"Амізон"
927:32511388
884:: 40–41.
544:and the
493:ATC code
474:Mongolia
208:10089466
93:ATC code
1065:9377379
992:8097484
918:7263517
901:bioRxiv
784:medRxiv
526:Germany
499:History
478:Belarus
374:354.191
336:Formula
228:8265003
194:PubChem
140:kidneys
109:)
103: (
101:J05AX17
1098:Amides
1063:
999:
989:
925:
915:
786:
536:, the
532:, the
528:, the
407:SMILES
279:ChEMBL
268:D11249
60:Amizon
18:Amizon
1088:Drugs
977:(4).
874:(PDF)
848:(PDF)
837:(PDF)
808:(PDF)
427:InChI
383:JSmol
130:liver
1061:PMID
997:PMID
923:PMID
259:KEGG
239:UNII
120:data
1042:doi
987:PMC
979:doi
913:PMC
905:doi
519:RNA
460:of
304:EPA
198:CID
106:WHO
74:4-(
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