1405:
266:. AMO is the first enzyme in ammonia oxidation. Aerobic oxidation of ammonia to hydroxylamine via AMO is an endergonic reaction. So, all aerobic ammonia oxidizing organisms conserve energy by further oxidizing hydroxylamine. It was believed that aerobic ammonia-oxidizing bacteria oxidize hydroxylamine to nitrite using octahaem
244:
151:
170:
882:
775:
336:
Bergmann DJ, Hooper AB (October 1994). "Sequence of the gene, amoB, for the 43-kDa polypeptide of ammonia monoxygenase of
Nitrosomonas europaea".
270:(HAO). Recently, it was shown that the product of HAO is not nitrite but nitric oxide, which is further oxidized to nitrite by an unknown enzyme.
950:
689:
535:
Arp DJ, Sayavedra-Soto LA, Hommes NG (October 2002). "Molecular biology and biochemistry of ammonia oxidation by
Nitrosomonas europaea".
850:
1124:
823:
163:
862:
808:
130:
106:
1280:
667:
267:
1091:
940:
1395:
682:
1265:
570:
Gilch S, Meyer O, Schmidt I (September 2009). "A soluble form of ammonia monooxygenase in
Nitrosomonas europaea".
124:
1381:
1368:
1355:
1342:
1329:
1316:
1303:
1086:
1047:
1037:
1023:
1019:
1009:
997:
977:
960:
928:
892:
792:
719:
1275:
1229:
1172:
710:
661:
191:
111:
29:
932:
1177:
723:
496:"Electron transfer during the oxidation of ammonia by the chemolithotrophic bacterium Nitrosomonas europaea"
175:
1071:
987:
736:
99:
373:"Evidence that particulate methane monooxygenase and ammonia monooxygenase may be evolutionarily related"
229:
1198:
1117:
867:
840:
675:
607:"Oxidation of monohalogenated ethanes and n-chlorinated alkanes by whole cells of Nitrosomonas europaea"
1270:
982:
945:
706:
127:
51:
1425:
1234:
968:
289:"Oxidation of methyl fluoride and dimethyl ether by ammonia monooxygenase in Nitrosomonas europaea"
1167:
731:
657:
877:
765:
636:
587:
552:
517:
476:
435:
394:
353:
318:
210:
118:
87:
1213:
1208:
1182:
1110:
626:
618:
579:
544:
507:
466:
425:
384:
345:
308:
300:
63:
1260:
1244:
1157:
855:
34:
1409:
1298:
1239:
1081:
1061:
1056:
698:
389:
372:
146:
631:
606:
512:
495:
430:
413:
313:
288:
1419:
1203:
1162:
471:
454:
414:"Evidence for an iron center in the ammonia monooxygenase from Nitrosomonas europaea"
622:
304:
1152:
900:
896:
1376:
1311:
1147:
1404:
1032:
548:
1350:
1324:
1001:
964:
908:
702:
206:
591:
556:
521:
349:
640:
480:
439:
398:
357:
322:
194:
75:
780:
455:"The purification of ammonia monooxygenase from Paracoccus denitrificans"
583:
1076:
216:
94:
1363:
1133:
918:
913:
872:
259:
202:
158:
70:
58:
46:
1337:
1065:
800:
758:
751:
746:
741:
845:
833:
828:
818:
813:
796:
770:
263:
82:
1106:
671:
371:
Holmes AJ, Costello A, Lidstrom ME, Murrell JC (October 1995).
412:
Zahn JA, Arciero DM, Hooper AB, DiSpirito AA (November 1996).
494:
Whittaker M, Bergmann D, Arciero D, Hooper AB (August 2000).
1102:
453:
Moir JW, Crossman LC, Spiro S, Richardson DJ (May 1996).
605:
Rasche ME, Hicks RE, Hyman MR, Arp DJ (September 1990).
233:
1393:
232:
1289:
1253:
1222:
1191:
1140:
1046:
1018:
996:
959:
927:
891:
791:
718:
500:
Biochimica et
Biophysica Acta (BBA) - Bioenergetics
338:
169:
157:
145:
140:
117:
105:
93:
81:
69:
57:
45:
40:
28:
23:
18:
238:
1118:
683:
8:
1125:
1111:
1103:
690:
676:
668:
137:
660:at the U.S. National Library of Medicine
630:
511:
470:
429:
388:
312:
287:Hyman MR, Page CL, Arp DJ (August 1994).
231:
1400:
279:
293:Applied and Environmental Microbiology
15:
7:
883:24-hydroxycholesterol 7α-hydroxylase
239:{\displaystyle \rightleftharpoons }
390:10.1111/j.1574-6968.1995.tb07834.x
14:
1403:
863:Cholesterol 7 alpha-hydroxylase
809:Flavin-containing monooxygenase
623:10.1128/jb.172.9.5368-5373.1990
305:10.1128/AEM.60.8.3033-3035.1994
258:Ammonia monooxygenase contains
1:
513:10.1016/s0005-2728(00)00171-7
431:10.1016/s0014-5793(96)01116-7
472:10.1016/0014-5793(96)00463-2
268:hydroxylamine oxidoreductase
1092:Deoxyhypusine monooxygenase
1442:
1281:Michaelis–Menten kinetics
1087:Ecdysone 20-monooxygenase
1038:Stearoyl-CoA desaturase-1
1010:Dopamine beta-hydroxylase
978:Phenylalanine hydroxylase
549:10.1007/s00203-002-0452-0
377:FEMS Microbiology Letters
136:
1173:Diffusion-limited enzyme
662:Medical Subject Headings
537:Archives of Microbiology
611:Journal of Bacteriology
1072:Squalene monooxygenase
988:Tryptophan hydroxylase
737:HIF prolyl-hydroxylase
350:10.1006/bbrc.1994.2524
240:
1266:Eadie–Hofstee diagram
1199:Allosteric regulation
868:Methane monooxygenase
841:Nitric oxide synthase
658:Ammonia+monooxygenase
262:and possibly nonheme
241:
188:Ammonia monooxygenase
19:Ammonia monooxygenase
1276:Lineweaver–Burk plot
983:Tyrosine hydroxylase
707:steroid hydroxylases
572:Biological Chemistry
230:
933:iron–sulfur protein
584:10.1515/BC.2009.085
1235:Enzyme superfamily
1168:Enzyme promiscuity
732:Prolyl hydroxylase
236:
1391:
1390:
1100:
1099:
766:Lysyl hydroxylase
211:chemical reaction
185:
184:
181:
180:
100:metabolic pathway
1433:
1408:
1407:
1399:
1271:Hanes–Woolf plot
1214:Enzyme activator
1209:Enzyme inhibitor
1183:Enzyme catalysis
1127:
1120:
1113:
1104:
692:
685:
678:
669:
645:
644:
634:
602:
596:
595:
567:
561:
560:
532:
526:
525:
515:
491:
485:
484:
474:
450:
444:
443:
433:
409:
403:
402:
392:
368:
362:
361:
333:
327:
326:
316:
284:
245:
243:
242:
237:
138:
16:
1441:
1440:
1436:
1435:
1434:
1432:
1431:
1430:
1416:
1415:
1414:
1402:
1394:
1392:
1387:
1299:Oxidoreductases
1285:
1261:Enzyme kinetics
1249:
1245:List of enzymes
1218:
1187:
1158:Catalytic triad
1136:
1131:
1101:
1096:
1050:- miscellaneous
1042:
1014:
992:
955:
923:
887:
878:14α-demethylase
787:
714:
699:Oxidoreductases
696:
654:
649:
648:
604:
603:
599:
569:
568:
564:
534:
533:
529:
506:(2–3): 346–55.
493:
492:
488:
452:
451:
447:
411:
410:
406:
370:
369:
365:
335:
334:
330:
286:
285:
281:
276:
253:
249:
228:
227:
226:
222:
12:
11:
5:
1439:
1437:
1429:
1428:
1418:
1417:
1413:
1412:
1389:
1388:
1386:
1385:
1372:
1359:
1346:
1333:
1320:
1307:
1293:
1291:
1287:
1286:
1284:
1283:
1278:
1273:
1268:
1263:
1257:
1255:
1251:
1250:
1248:
1247:
1242:
1237:
1232:
1226:
1224:
1223:Classification
1220:
1219:
1217:
1216:
1211:
1206:
1201:
1195:
1193:
1189:
1188:
1186:
1185:
1180:
1175:
1170:
1165:
1160:
1155:
1150:
1144:
1142:
1138:
1137:
1132:
1130:
1129:
1122:
1115:
1107:
1098:
1097:
1095:
1094:
1089:
1084:
1079:
1074:
1069:
1062:Heme oxygenase
1059:
1057:Cyclooxygenase
1053:
1051:
1044:
1043:
1041:
1040:
1035:
1029:
1027:
1016:
1015:
1013:
1012:
1006:
1004:
994:
993:
991:
990:
985:
980:
974:
972:
957:
956:
954:
953:
948:
943:
937:
935:
925:
924:
922:
921:
916:
911:
905:
903:
889:
888:
886:
885:
880:
875:
870:
865:
860:
859:
858:
853:
848:
838:
837:
836:
831:
826:
821:
816:
805:
803:
789:
788:
786:
785:
784:
783:
778:
768:
763:
762:
761:
756:
755:
754:
749:
744:
728:
726:
724:2-oxoglutarate
716:
715:
697:
695:
694:
687:
680:
672:
666:
665:
653:
652:External links
650:
647:
646:
617:(9): 5368–73.
597:
562:
527:
486:
445:
404:
363:
328:
278:
277:
275:
272:
256:
255:
251:
247:
235:
224:
220:
209:the following
183:
182:
179:
178:
173:
167:
166:
161:
155:
154:
149:
143:
142:
134:
133:
122:
115:
114:
109:
103:
102:
97:
91:
90:
85:
79:
78:
73:
67:
66:
61:
55:
54:
49:
43:
42:
38:
37:
32:
26:
25:
21:
20:
13:
10:
9:
6:
4:
3:
2:
1438:
1427:
1424:
1423:
1421:
1411:
1406:
1401:
1397:
1383:
1379:
1378:
1373:
1370:
1366:
1365:
1360:
1357:
1353:
1352:
1347:
1344:
1340:
1339:
1334:
1331:
1327:
1326:
1321:
1318:
1314:
1313:
1308:
1305:
1301:
1300:
1295:
1294:
1292:
1288:
1282:
1279:
1277:
1274:
1272:
1269:
1267:
1264:
1262:
1259:
1258:
1256:
1252:
1246:
1243:
1241:
1240:Enzyme family
1238:
1236:
1233:
1231:
1228:
1227:
1225:
1221:
1215:
1212:
1210:
1207:
1205:
1204:Cooperativity
1202:
1200:
1197:
1196:
1194:
1190:
1184:
1181:
1179:
1176:
1174:
1171:
1169:
1166:
1164:
1163:Oxyanion hole
1161:
1159:
1156:
1154:
1151:
1149:
1146:
1145:
1143:
1139:
1135:
1128:
1123:
1121:
1116:
1114:
1109:
1108:
1105:
1093:
1090:
1088:
1085:
1083:
1080:
1078:
1075:
1073:
1070:
1067:
1063:
1060:
1058:
1055:
1054:
1052:
1049:
1045:
1039:
1036:
1034:
1031:
1030:
1028:
1025:
1021:
1017:
1011:
1008:
1007:
1005:
1003:
999:
995:
989:
986:
984:
981:
979:
976:
975:
973:
970:
969:BH4 dependent
966:
962:
958:
952:
949:
947:
944:
942:
939:
938:
936:
934:
930:
926:
920:
917:
915:
912:
910:
907:
906:
904:
902:
898:
894:
890:
884:
881:
879:
876:
874:
871:
869:
866:
864:
861:
857:
854:
852:
849:
847:
844:
843:
842:
839:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
811:
810:
807:
806:
804:
802:
798:
794:
790:
782:
779:
777:
774:
773:
772:
769:
767:
764:
760:
757:
753:
750:
748:
745:
743:
740:
739:
738:
735:
734:
733:
730:
729:
727:
725:
721:
717:
712:
708:
704:
700:
693:
688:
686:
681:
679:
674:
673:
670:
663:
659:
656:
655:
651:
642:
638:
633:
628:
624:
620:
616:
612:
608:
601:
598:
593:
589:
585:
581:
578:(9): 863–73.
577:
573:
566:
563:
558:
554:
550:
546:
542:
538:
531:
528:
523:
519:
514:
509:
505:
501:
497:
490:
487:
482:
478:
473:
468:
464:
460:
456:
449:
446:
441:
437:
432:
427:
423:
419:
415:
408:
405:
400:
396:
391:
386:
382:
378:
374:
367:
364:
359:
355:
351:
347:
344:(2): 759–62.
343:
339:
332:
329:
324:
320:
315:
310:
306:
302:
299:(8): 3033–5.
298:
294:
290:
283:
280:
273:
271:
269:
265:
261:
218:
215:
214:
213:
212:
208:
204:
200:
196:
193:
189:
177:
174:
172:
168:
165:
162:
160:
156:
153:
150:
148:
144:
139:
135:
132:
129:
126:
123:
120:
116:
113:
110:
108:
104:
101:
98:
96:
92:
89:
86:
84:
80:
77:
76:NiceZyme view
74:
72:
68:
65:
62:
60:
56:
53:
50:
48:
44:
39:
36:
33:
31:
27:
22:
17:
1377:Translocases
1374:
1361:
1348:
1335:
1322:
1312:Transferases
1309:
1296:
1153:Binding site
901:flavoprotein
705:, including
703:dioxygenases
614:
610:
600:
575:
571:
565:
543:(4): 250–5.
540:
536:
530:
503:
499:
489:
462:
459:FEBS Letters
458:
448:
421:
418:FEBS Letters
417:
407:
383:(3): 203–8.
380:
376:
366:
341:
337:
331:
296:
292:
282:
257:
198:
187:
186:
64:BRENDA entry
1148:Active site
465:(1): 71–4.
424:(1): 35–8.
52:IntEnz view
24:Identifiers
1426:EC 1.14.99
1351:Isomerases
1325:Hydrolases
1192:Regulation
1033:Tyrosinase
1000:: reduced
963:: reduced
931:: reduced
895:: reduced
274:References
250:OH + A + H
195:1.14.99.39
121:structures
88:KEGG entry
35:1.14.99.39
1230:EC number
1002:ascorbate
965:pteridine
234:⇌
207:catalyses
41:Databases
1420:Category
1254:Kinetics
1178:Cofactor
1141:Activity
592:19453274
557:12209257
522:11004450
205:, which
201:) is an
176:proteins
164:articles
152:articles
125:RCSB PDB
1410:Biology
1364:Ligases
1134:Enzymes
1048:1.14.99
1026:: other
1020:1.14.18
998:1.14.17
961:1.14.16
929:1.14.15
893:1.14.14
793:1.14.13
720:1.14.11
641:2394686
481:8654570
440:8941709
399:7590173
358:7980540
323:8085841
217:ammonia
112:profile
95:MetaCyc
1396:Portal
1338:Lyases
897:flavin
776:ALKBH1
664:(MeSH)
639:
632:213201
629:
590:
555:
520:
479:
438:
397:
356:
321:
314:201762
311:
260:copper
203:enzyme
159:PubMed
141:Search
131:PDBsum
71:ExPASy
59:BRENDA
47:IntEnz
30:EC no.
1290:Types
1066:HMOX1
801:NADPH
759:P4HTM
752:EGLN3
747:EGLN2
742:EGLN1
713:1.14)
107:PRIAM
1382:list
1375:EC7
1369:list
1362:EC6
1356:list
1349:EC5
1343:list
1336:EC4
1330:list
1323:EC3
1317:list
1310:EC2
1304:list
1297:EC1
1082:21A2
1077:17A1
951:11A1
946:11B2
941:11B1
909:19A1
856:NOS3
851:NOS2
846:NOS1
834:FMO5
829:FMO4
824:FMO3
819:FMO2
814:FMO1
797:NADH
771:AlkB
637:PMID
588:PMID
553:PMID
518:PMID
504:1459
477:PMID
436:PMID
395:PMID
354:PMID
319:PMID
264:iron
219:+ AH
171:NCBI
128:PDBe
83:KEGG
919:2E1
914:2D6
899:or
873:3A4
799:or
781:FTO
627:PMC
619:doi
615:172
580:doi
576:390
545:doi
541:178
508:doi
467:doi
463:387
426:doi
422:397
385:doi
381:132
346:doi
342:204
309:PMC
301:doi
223:+ O
199:AMO
147:PMC
119:PDB
1422::
1024:19
795::
722::
711:EC
701::
635:.
625:.
613:.
609:.
586:.
574:.
551:.
539:.
516:.
502:.
498:.
475:.
461:.
457:.
434:.
420:.
416:.
393:.
379:.
375:.
352:.
340:.
317:.
307:.
297:60
295:.
291:.
246:NH
197:,
192:EC
1398::
1384:)
1380:(
1371:)
1367:(
1358:)
1354:(
1345:)
1341:(
1332:)
1328:(
1319:)
1315:(
1306:)
1302:(
1126:e
1119:t
1112:v
1068:)
1064:(
1022:-
971:)
967:(
709:(
691:e
684:t
677:v
643:.
621::
594:.
582::
559:.
547::
524:.
510::
483:.
469::
442:.
428::
401:.
387::
360:.
348::
325:.
303::
254:O
252:2
248:2
225:2
221:2
190:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.