2376:(a) A low magnification image immediately after co-injection of red negatively charged and green glycine-conjugated beads showing the injection site, marked with an oil droplet, appearing as a round yellow sphere. Overlap of red and green fluorescence produces a yellow image. (b) At 50 min after injection, the red carboxylated beads have progressed in the anterograde direction (to the right) while the green glycine-conjugated beads have made no progress. (c)–(e) An axon co-injected with red APP-C beads and green glycine beads and imaged for 100 frames at 4 s intervals at 40× magnification. (c) Red channel (left) first frame; (center) 50 frames superimposed; (right) all 100 frames superimposed. Note the progression of individual beads towards the right, anterograde, side of the injection site heading towards the presynaptic terminal. (d) Two images of the green channel from the same video sequence; (left) first frame; (center) 100 frames superimposed. Note the lack of significant movement of the green glycine beads. (e) Both red and green channels from 100 frames superimposed of the same video as in (c) and (d). (f) Single bead trajectories at high magnification from a set of superimposed frames showing movements of beads.
2373:
767:
744:
7287:
7482:
7302:
7557:
7452:
7497:
7512:
641:
666:
7527:
2610:
and is crucial for normal neuronal function. APP751 and APP770 are more widely expressed in non-neuronal tissues but exhibit distinct expression patterns during neuron differentiation. The differential expression of these isoforms plays a significant role in cellular processes such as neurodevelopment, synaptic plasticity, and the pathogenesis of
Alzheimer's disease. Understanding the isoform diversity of APP is essential for deciphering its various physiological and pathological roles.
7422:
7542:
7227:
2614:
7377:
7572:
7437:
7347:
7257:
7242:
7317:
7272:
7467:
7362:
2601:-binding domain (CuBD) interacting tightly together. A serine protease inhibitor domain, absent from the isoform differentially expressed in the brain, is found between acidic region and E2 domain. The complete crystal structure of APP has not yet been solved; however, individual domains have been successfully crystallized, the growth factor-like domain, the copper-binding domain, the complete E1 domain and the E2 domain.
773:
672:
7332:
7407:
7392:
38:
2560:
2698:. When APP molecules occupy a lipid raft region of membrane, they are more accessible to and differentially cleaved by beta secretase, whereas APP molecules outside a raft are differentially cleaved by the non-amyloidogenic alpha secretase. Gamma secretase activity has also been associated with lipid rafts. The role of
2536:
3961:
Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, Stefansson H, Sulem P, Gudbjartsson D, Maloney J, Hoyte K, Gustafson A, Liu Y, Lu Y, Bhangale T, Graham RR, Huttenlocher J, Bjornsdottir G, Andreassen OA, Jönsson EG, Palotie A, Behrens TW, Magnusson OT, Kong A, Thorsteinsdottir U,
2879:
As APP does not possess ferroxidase activity within its E2 domain, the mechanism of APP-modulated iron efflux from ferroportin has come under scrutiny. One model suggests that APP acts to stabilize the iron efflux protein ferroportin in the plasma membrane of cells thereby increasing the total number
2776:
The logical inference is that because Aβ accumulates excessively in
Alzheimer's disease its precursor, APP, would be elevated as well. However, neuronal cell bodies contain less APP as a function of their proximity to amyloid plaques. The data indicate that this deficit in APP results from a decline
2609:
Amyloid-beta precursor protein is highly versatile with several isoforms generated through alternative splicing of its mRNA. The primary isoforms include APP695, APP751, and APP770, differing in their inclusion of certain exons, mainly exon 7 and 8. APP695 is predominantly expressed in neuronal cells
2522:
Mutations in critical regions of amyloid precursor protein, including the region that generates amyloid beta (Aβ), cause familial susceptibility to
Alzheimer's disease. For example, several mutations outside the Aβ region associated with familial Alzheimer's have been found to dramatically increase
4374:
Chen F, Hasegawa H, Schmitt-Ulms G, Kawarai T, Bohm C, Katayama T, Gu Y, Sanjo N, Glista M, Rogaeva E, Wakutani Y, Pardossi-Piquard R, Ruan X, Tandon A, Checler F, Marambaud P, Hansen K, Westaway D, St George-Hyslop P, Fraser P (Apr 2006). "TMP21 is a presenilin complex component that modulates
64:
1032:
1025:
1018:
4240:
Kong GK, Adams JJ, Harris HH, Boas JF, Curtain CC, Galatis D, Masters CL, Barnham KJ, McKinstry WJ, Cappai R, Parker MW (Mar 2007). "Structural studies of the
Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions".
2592:
that fold mostly on their own have been found in the APP sequence. The extracellular region, much larger than the intracellular region, is divided into the E1 and E2 domains, linked by an acidic domain (AcD); E1 contains two subdomains including a
7286:
6235:
Yan SD, Fu J, Soto C, Chen X, Zhu H, Al-Mohanna F, Collison K, Zhu A, Stern E, Saido T, Tohyama M, Ogawa S, Roher A, Stern D (Oct 1997). "An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in
Alzheimer's disease".
2494:
isoforms of APP have been observed in humans, ranging in length from 639 to 770 amino acids, with certain isoforms preferentially expressed in neurons; changes in the neuronal ratio of these isoforms have been associated with
Alzheimer's disease.
7481:
4189:
Rossjohn J, Cappai R, Feil SC, Henry A, McKinstry WJ, Galatis D, Hesse L, Multhaup G, Beyreuther K, Masters CL, Parker MW (Apr 1999). "Crystal structure of the N-terminal, growth factor-like domain of
Alzheimer amyloid precursor protein".
3909:
Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ (Dec 1992). "Mutation of the beta-amyloid precursor protein in familial
Alzheimer's disease increases beta-protein production".
3308:
Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, Tanzi RE, Cappai R, Barnham KJ, Ciccotosto GD, Rogers JT, Bush AI (Sep 2010).
3708:
Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L (Feb 1991). "Segregation of a missense mutation in the amyloid precursor protein gene with familial
Alzheimer's disease".
2923:
products do not promote the proliferation and differentiation of post-mitotic neurons; rather, the overexpression of either wild-type or mutant AβPP in post-mitotic neurons induces apoptotic death following their re-entry into the
7301:
7556:
2772:
effects including impaired long-term potentiation and memory loss without general neuron loss. On the other hand, transgenic mice with upregulated APP expression have also been reported to show impaired long-term potentiation.
7451:
2875:
The hypothesis that APP has ferroxidase activity in its E2 domain and facilitates export of Fe(II) is possibly incorrect since the proposed ferroxidase site of APP located in the E2 domain does not have ferroxidase activity.
6381:
Beyreuther K, Pollwein P, Multhaup G, Mönning U, König G, Dyrks T, Schubert W, Masters CL (Sep 1993). "Regulation and expression of the
Alzheimer's beta/A4 amyloid protein precursor in health, disease, and Down's syndrome".
7496:
7511:
2686:
within the membrane-spanning domain after beta-secretase cleavage generates the amyloid-beta fragment; gamma secretase is a large multi-subunit complex whose components have not yet been fully characterized, but include
2526:
A mutation (A673T) in the APP gene protects against Alzheimer's disease. This substitution is adjacent to the beta secretase cleavage site and results in a 40% reduction in the formation of amyloid beta in vitro.
5141:
Porayette P, Gallego MJ, Kaltcheva MM, Meethal SV, Atwood CS (Dec 2007). "Amyloid-beta precursor protein expression and modulation in human embryonic stem cells: a novel role for human chorionic gonadotropin".
3503:
Lamb BT, Sisodia SS, Lawler AM, Slunt HH, Kitt CA, Kearns WG, Pearson PL, Price DL, Gearhart JD (Sep 1993). "Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice ".
7526:
2832:, such that they display the same terminal carboxylic acid group as APP without the intervening 15-amino-acid sequence mentioned above. The control beads were not motile, which demonstrated that the terminal
20:
7421:
7541:
4702:"Relationships between expression of apolipoprotein E and beta-amyloid precursor protein are altered in proximity to Alzheimer beta-amyloid plaques: potential explanations from cell culture studies"
2617:
Amyloid-beta precursor protein exon 7 & 8 dependent transcript variant abundance (Transcript variant groups containing major transcript variant 1, 2, 3 and, 11) in the immature (proliferative)
7226:
2824:
Additionally, it has been shown that the interaction between APP and kinesin is specific to the peptide sequence of APP. In a recent experiment involving transport of peptide-conjugated colored
6594:
Kerr ML, Small DH (Apr 2005). "Cytoplasmic domain of the beta-amyloid protein precursor of Alzheimer's disease: function, regulation of proteolysis, and implications for drug development".
6750:, Esh C, Luehrs DC, Stine WB, Rowse LM, Emmerling MR, Roher AE (Dec 2005). "Physicochemical characteristics of soluble oligomeric Abeta and their pathologic role in Alzheimer's disease".
2753:
have been proposed and supported by as-yet limited research. In particular, similarities in post-translational processing have invited comparisons to the signaling role of the surface
2821:
and thus facilitate this transport. Specifically, a short peptide 15-amino-acid sequence from the cytoplasmic carboxy-terminus is necessary for interaction with the motor protein.
7376:
7571:
2372:
6520:
Van Nostrand WE, Melchor JP, Romanov G, Zeigler K, Davis J (Nov 2002). "Pathogenic effects of cerebral amyloid angiopathy mutations in the amyloid beta-protein precursor".
6941:
Menéndez-González M, Pérez-Pinera P, Martínez-Rivera M, Calatayud MT, Blázquez Menes B (2006). "APP processing and the APP-KPI domain involvement in the amyloid cascade".
3547:
Matsui T, Ingelsson M, Fukumoto H, Ramasamy K, Kowa H, Frosch MP, Irizarry MC, Hyman BT (Aug 2007). "Expression of APP pathway mRNAs and proteins in Alzheimer's disease".
2555:
residues that play a role in metal coordination are shown in the Cu(I) bound, Cu(II) bound, and unbound conformations, which differ by only small changes in orientation.
7436:
7097:"When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40. Talking Point on the role of presenilin mutations in Alzheimer disease"
5279:"The pregnancy hormones human chorionic gonadotropin and progesterone induce human embryonic stem cell proliferation and differentiation into neuroectodermal rosettes"
780:
679:
7346:
5648:"Interaction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteins"
3860:"Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier - phenotypic variability in autosomal dominant Alzheimer's disease"
3221:
Turner PR, O'Connor K, Tate WP, Abraham WC (May 2003). "Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory".
5330:"DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3"
2515:. The amyloid beta region of the protein, located in the membrane-spanning domain, is not well conserved across species and has no obvious connection with APP's
7295:: THE SOLUTION STRUCTURE OF AMYLOID BETA-PEPTIDE (1-40) IN A WATER-MICELLE ENVIRONMENT. IS THE MEMBRANE-SPANNING DOMAIN WHERE WE THINK IT IS? NMR, 10 STRUCTURES
2718:
7734:
5179:"Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells"
7913:
4927:"Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease"
6565:
Ling Y, Morgan K, Kalsheker N (Nov 2003). "Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease".
6419:
Straub JE, Guevara J, Huo S, Lee JP (Jun 2002). "Long time dynamic simulations: exploring the folding pathways of an Alzheimer's amyloid Abeta-peptide".
7256:
7241:
5932:"Uncleaved BAP31 in association with A4 protein at the endoplasmic reticulum is an inhibitor of Fas-initiated release of cytochrome c from mitochondria"
2005:
602:
5531:"Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism"
4657:
Matsuyama S, Teraoka R, Mori H, Tomiyama T (2007). "Inverse correlation between amyloid precursor protein and synaptic plasticity in transgenic mice".
7316:
1986:
7271:
3760:
Murrell J, Farlow M, Ghetti B, Benson MD (Oct 1991). "A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease".
7490:: Structure of the Alzheimer's Amyloid Precursor Protein (APP) copper binding domain (residues 133 to 189) in 'small unit cell' form, metal-free
7310:: SOLUTION STRUCTURE OF THE METHIONINE-OXIDIZED AMYLOID BETA-PEPTIDE (1-40). DOES OXIDATION AFFECT CONFORMATIONAL SWITCHING? NMR, 10 STRUCTURES
5746:
Tanahashi H, Tabira T (Feb 1999). "Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein".
3807:, Roques P, Hardy J (Oct 1991). "Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene".
2880:
of ferroportin molecules at the membrane. These iron-transporters can then be activated by known mammalian ferroxidases (i.e. ceruloplasmin or
5611:
Tanahashi H, Tabira T (Feb 1999). "X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein".
3963:
7903:
7612:
7206:
3128:
7466:
7719:
7361:
5379:"Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition"
3110:
2777:
in production rather than an increase in catalysis. Loss of a neuron's APP may affect physiological deficits that contribute to dementia.
7460:: Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Kunitz Protease Inhibitor Domain of Protease Nexin II
2721:
are commonly used by researchers to gain better understandings about the biological function of APP in disease pathology and progression.
3468:
Yoshikai S, Sasaki H, Doh-ura K, Furuya H, Sakaki Y (Mar 1990). "Genomic organization of the human amyloid beta-protein precursor gene".
766:
2717:
Although the native biological role of APP is of obvious interest to Alzheimer's research, thorough understanding has remained elusive.
2313:
2892:
The amyloid-β precursor protein (AβPP), and all associated secretases, are expressed early in development and play a key role in the
2320:
743:
7166:
5646:
Zambrano N, Buxbaum JD, Minopoli G, Fiore F, De Candia P, De Renzis S, Faraonio R, Sabo S, Cheetham J, Sudol M, Russo T (Mar 1997).
6102:
Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T (Apr 2002).
6840:
Vetrivel KS, Thinakaran G (Jan 2006). "Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments".
7565:: Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, atomic resolution
6020:
Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T (Jun 2004).
5479:"The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein"
4976:"A synthetic peptide with the putative iron binding motif of amyloid precursor protein (APP) does not catalytically oxidize iron"
7908:
7160:
4611:
3097:
3076:
2635:
7331:
4339:
De Strooper B, Annaert W (Jun 2000). "Proteolytic processing and cell biological functions of the amyloid precursor protein".
3858:
Lloyd GM, Trejo-Lopez JA, Xia Y, McFarland KN, Lincoln SJ, Ertekin-Taner N, Giasson BI, Yachnis AT, Prokop S (12 March 2020).
2813:
Molecules synthesized in the cell bodies of neurons must be conveyed outward to the distal synapses. This is accomplished via
6200:
Chauhan VP, Ray I, Chauhan A, Wisniewski HM (May 1999). "Binding of gelsolin, a secretory protein, to amyloid beta-protein".
2861:
665:
640:
7505:: Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, Cu(II)-bound
5094:"sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin"
4614:(1999). "No hippocampal neuron or synaptic bouton loss in learning-impaired aged beta-amyloid precursor protein-null mice".
3093:
7520:: Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'small unit cell' form, Cu(I)-bound
61:
7821:
4752:
Lee MH, Siddoway B, Kaeser GE, Segota I, Rivera R, Romanow WJ, Liu CS, Park C, Kennedy G, Long T, Chun J (November 2018).
4575:
Selkoe D, Kopan R (2003). "Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration".
2893:
7406:
7172:
3072:
7729:
2909:
582:
7928:
7780:
7775:
7759:
5791:"Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein"
4925:
Rogers JT, Bush AI, Cho HH, Smith DH, Thomson AM, Friedlich AL, Lahiri DK, Leedman PJ, Huang X, Cahill CM (Dec 2008).
3016:
2949:
6022:"Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation"
2860:; it seems that this activity is blocked by zinc trapped by accumulated Aβ in Alzheimer's. It has been shown that a
7430:: Solution structure of CAPPD*, an independently folded extracellular domain of human Amyloid-beta Precursor Protein
6153:"Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function"
4300:"A novel APP splice variant-dependent marker system to precisely demarcate maturity in SH-SY5Y cell-derived neurons"
7803:
7683:
7023:
6104:"CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV"
779:
678:
5689:"Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein"
5328:
McPhie DL, Coopersmith R, Hines-Peralta A, Chen Y, Ivins KJ, Manly SP, Kozlowski MR, Neve KA, Neve RL (Jul 2003).
7744:
7663:
7605:
7199:
6063:"Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein"
5873:"PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein"
2897:
2594:
2388:
772:
671:
7849:
7724:
7550:: Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain (Residues 126- 189 of APP)
7154:
6289:"Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc"
2905:
2050:
590:
7535:: Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'large unit cell' form
7391:
6328:
Hoe HS, Lee KJ, Carney RS, Lee J, Markova A, Lee JY, Howell BW, Hyman BT, Pak DT, Bu G, Rebeck GW (Jun 2009).
4870:"Quantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon"
3311:"Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease"
2916:
directs AβPP processing towards the non-amyloidogenic pathway, which promotes hESC differentiation into NPC.
7918:
5572:"Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein"
2702:
in lipid raft maintenance has been cited as a likely explanation for observations that high cholesterol and
2031:
573:, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, amyloid beta precursor protein, preA4, alpha-sAPP
5425:"Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms"
7785:
2798:
2754:
2746:
2507:
2452:
2424:
19:"APPI" redirects here. For the former Professional Association of Independent Phonographic Producers, see
4142:"Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system"
7235:: X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR
6799:"New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium"
2853:
2790:
2404:
654:
5832:"APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein"
2844:
A different perspective on Alzheimer's is revealed by a mouse study that has found that APP possesses
7923:
7649:
7598:
7192:
7150:
6529:
6245:
5884:
5700:
5046:
4987:
4881:
4822:
4765:
4531:
4087:
4076:"Structure and biochemical analysis of the heparin-induced E1 dimer of the amyloid precursor protein"
3975:
3919:
3816:
3769:
3718:
3371:
2814:
2738:
2491:
6980:"Dysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosis"
7654:
7178:
2929:
2292:
2288:
2284:
2280:
2251:
2247:
2243:
2233:
2229:
2225:
2221:
2193:
2189:
2185:
2181:
2160:
2152:
2148:
2144:
2140:
2130:
2126:
2122:
569:
6674:
Tickler AK, Wade JD, Separovic F (Aug 2005). "The role of Abeta peptides in Alzheimer's disease".
5570:
Tomita S, Ozaki T, Taru H, Oguchi S, Takeda S, Yagi Y, Sakiyama S, Kirino Y, Suzuki T (Jan 1999).
6966:
6929:
6865:
6828:
6785:
6747:
6619:
6553:
6508:
6407:
6269:
6182:
6002:
5771:
4682:
4639:
4557:
4520:"Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts"
4420:"Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts"
4400:
4215:
3999:
3943:
3840:
3742:
3572:
3529:
3246:
2901:
2651:
2496:
2464:
614:
4868:
Seamster PE, Loewenberg M, Pascal J, Chauviere A, Gonzales A, Cristini V, Bearer EL (Oct 2012).
4467:
Vetrivel KS, Cheng H, Lin W, Sakurai T, Li T, Nukina N, Wong PC, Xu H, Thinakaran G (Oct 2004).
2928:. It is postulated that the loss of sex steroids (including progesterone) but the elevation in
2296:
2259:
2255:
2217:
2197:
2156:
2118:
2114:
4032:"The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain"
7126:
7083:
7040:
7009:
6958:
6921:
6886:
6857:
6820:
6777:
6734:
6691:
6662:
6611:
6582:
6545:
6500:
6479:"The beta-amyloid precursor protein (APP) and Alzheimer's disease: does the tail wag the dog?"
6465:
6436:
6399:
6359:
6310:
6261:
6217:
6174:
6133:
6084:
6043:
5994:
5953:
5912:
5853:
5812:
5763:
5728:
5669:
5628:
5593:
5552:
5508:
5456:
5400:
5359:
5310:
5259:
5210:
5177:
Porayette P, Gallego MJ, Kaltcheva MM, Bowen RL, Vadakkadath Meethal S, Atwood CS (Aug 2009).
5159:
5123:
5074:
5015:
4956:
4907:
4850:
4791:
4731:
4674:
4631:
4592:
4549:
4500:
4449:
4392:
4356:
4258:
4207:
4171:
4115:
4053:
4020:
3991:
3935:
3891:
3832:
3785:
3734:
3690:
3632:
3614:
3564:
3521:
3485:
3450:
3399:
3340:
3287:
3238:
3203:
2613:
2412:
2408:
2392:
562:
54:
6461:
7836:
7161:
Entrez Gene: APP amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
7116:
7108:
7073:
7065:
7032:
6999:
6991:
6950:
6911:
6849:
6810:
6767:
6759:
6724:
6716:
6683:
6652:
6644:
6603:
6574:
6537:
6490:
6457:
6428:
6391:
6349:
6341:
6300:
6253:
6209:
6164:
6123:
6115:
6074:
6033:
5984:
5943:
5930:
Wang B, Nguyen M, Breckenridge DG, Stojanovic M, Clemons PA, Kuppig S, Shore GC (Apr 2003).
5902:
5892:
5843:
5802:
5755:
5718:
5708:
5659:
5620:
5583:
5542:
5498:
5490:
5446:
5436:
5390:
5377:
Bowen RL, Verdile G, Liu T, Parlow AF, Perry G, Smith MA, Martins RN, Atwood CS (May 2004).
5349:
5341:
5300:
5290:
5249:
5241:
5200:
5190:
5151:
5113:
5105:
5064:
5054:
5005:
4995:
4946:
4938:
4897:
4889:
4840:
4830:
4781:
4773:
4721:
4713:
4666:
4623:
4584:
4539:
4490:
4480:
4439:
4431:
4384:
4348:
4319:
4311:
4250:
4199:
4161:
4153:
4105:
4095:
4043:
3983:
3927:
3881:
3871:
3824:
3777:
3726:
3680:
3670:
3622:
3606:
3556:
3513:
3477:
3440:
3430:
3389:
3379:
3330:
3322:
3277:
3230:
3193:
3183:
2703:
2589:
859:
790:
734:
689:
6900:"Does the p75 neurotrophin receptor mediate Abeta-induced toxicity in Alzheimer's disease?"
6798:
4588:
7878:
7856:
7826:
7639:
5277:
Gallego MJ, Porayette P, Kaltcheva MM, Bowen RL, Vadakkadath Meethal S, Atwood CS (2010).
3964:"A mutation in APP protects against Alzheimer's disease and age-related cognitive decline"
3590:
2833:
2758:
2734:
2730:
2683:
2667:
2643:
2578:
834:
7580:: Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40)
7021:
Chen X, Stern D, Yan SD (Dec 2006). "Mitochondrial dysfunction and Alzheimer's disease".
6448:
Annaert W, De Strooper B (2003). "A cell biological perspective on Alzheimer's disease".
4811:"A peptide zipcode sufficient for anterograde transport within amyloid precursor protein"
610:
6533:
6249:
5888:
5704:
5050:
4991:
4885:
4826:
4769:
4535:
4324:
4299:
4091:
3979:
3923:
3820:
3773:
3722:
3375:
7714:
7709:
7121:
7096:
7078:
7053:
7004:
6979:
6853:
6729:
6704:
6657:
6632:
6541:
6395:
6354:
5451:
5441:
5424:
5354:
5345:
5329:
5305:
5278:
5254:
5229:
5205:
5178:
5118:
5093:
5069:
5035:"The amyloid precursor protein (APP) does not have a ferroxidase site in its E2 domain"
5034:
5010:
4975:
4951:
4926:
4902:
4893:
4869:
4845:
4810:
4786:
4753:
4726:
4701:
4495:
4468:
4444:
4419:
4166:
4157:
4141:
4110:
4075:
3886:
3859:
3685:
3658:
3627:
3594:
3445:
3418:
3394:
3359:
3335:
3310:
3198:
3171:
2742:
2671:
2448:
1031:
1024:
7385:: Structure of the Alzheimer's disease amyloid precursor protein copper binding domain
6578:
6128:
6103:
5759:
5503:
5478:
5033:
Honarmand Ebrahimi K, Dienemann C, Hoefgen S, Than ME, Hagedoorn PL, Hagen WR (2013).
4627:
4544:
4519:
4469:"Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes"
3234:
3052:, a protein implicated in a number of brain disorders, including Alzheimer's disease.
2940:
drives amyloid-β production and re-entry of post-mitotic neurons into the cell cycle.
1920:
1915:
1910:
1905:
1900:
1895:
1890:
1885:
1880:
1875:
1870:
1865:
1860:
1855:
1850:
1845:
1840:
1835:
1830:
1825:
1820:
1815:
1810:
1805:
1800:
1795:
1790:
1785:
1780:
1775:
1770:
1765:
1760:
1755:
1750:
1745:
1740:
1735:
1730:
1725:
1720:
1715:
1710:
1705:
1700:
1695:
1690:
1685:
1680:
1675:
1670:
1665:
1660:
1655:
1650:
1645:
1640:
1635:
1630:
1625:
1620:
1615:
1610:
1605:
1600:
1595:
1590:
1585:
1580:
1575:
1570:
1565:
1560:
1555:
1550:
1545:
1540:
1535:
1530:
1525:
1520:
1515:
1510:
1505:
1500:
1495:
1490:
1485:
1480:
1475:
1470:
1465:
1460:
1455:
1450:
1445:
1440:
1435:
1430:
1425:
1420:
1404:
1399:
1394:
1389:
1384:
1379:
1374:
1369:
1364:
1359:
1354:
1349:
1344:
1339:
1334:
1329:
1324:
1319:
1314:
1309:
1304:
1299:
1294:
1289:
1284:
1279:
1274:
1269:
1264:
1259:
1254:
1249:
1244:
1239:
1234:
1229:
1224:
1219:
1214:
1209:
1204:
1199:
1194:
1189:
1184:
1179:
1174:
1169:
1164:
1159:
1143:
1138:
1133:
1128:
1123:
1118:
1113:
1108:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
37:
7897:
7644:
6916:
6899:
6797:
Calinisan V, Gravem D, Chen RP, Brittin S, Mohandas N, Lecomte MC, Gascard P (2006).
6648:
6495:
6478:
6169:
6152:
5907:
5872:
5723:
5688:
3804:
3481:
2920:
2849:
2765:
2750:
2639:
2479:
1060:
6970:
6933:
6869:
6832:
6789:
6705:"The amyloid-beta precursor protein: integrating structure with biological function"
6623:
6557:
6512:
6411:
6186:
6006:
5775:
5529:
Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T (Dec 2003).
4686:
4561:
4219:
3576:
3533:
3250:
1017:
7861:
7659:
6345:
6273:
4643:
4404:
4003:
3947:
3844:
3746:
3560:
3360:"Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol"
3188:
2913:
2805:
gene diversity due to somatic recombination than neurons from healthy individuals.
2581:
2516:
2432:
852:
631:
3803:
Chartier-Harlin MC, Crawford F, Houlden H, Warren A, Hughes D, Fidani L, Goate A,
594:
7069:
6995:
6330:"Interaction of reelin with amyloid precursor protein promotes neurite outgrowth"
6329:
5059:
5000:
4717:
4670:
4048:
4031:
2691:, whose gene has been identified as a major genetic risk factor for Alzheimer's.
618:
7767:
7753:
7621:
7054:"Focal adhesions regulate Abeta signaling and cell death in Alzheimer's disease"
5973:"Human bleomycin hydrolase regulates the secretion of amyloid precursor protein"
3282:
3265:
3170:
Priller C, Bauer T, Mitteregger G, Krebs B, Kretzschmar HA, Herms J (Jul 2006).
3133:
National Center for Biotechnology Information, U.S. National Library of Medicine
3115:
National Center for Biotechnology Information, U.S. National Library of Medicine
2857:
2845:
2825:
2699:
2674:
both remove nearly the entire extracellular domain to release membrane-anchored
2655:
2647:
2564:
2436:
2428:
2416:
7036:
5877:
Proceedings of the National Academy of Sciences of the United States of America
5693:
Proceedings of the National Academy of Sciences of the United States of America
5230:"Opioid and progesterone signaling is obligatory for early human embryogenesis"
5155:
4815:
Proceedings of the National Academy of Sciences of the United States of America
4315:
4298:
Kulatunga DC, Ranaraja U, Kim EY, Kim RE, Kim DE, Ji KB, Kim MK (27 May 2024).
4080:
Proceedings of the National Academy of Sciences of the United States of America
3326:
935:
7873:
7813:
7688:
7673:
7145:
6119:
4777:
4254:
3876:
3610:
3358:
Wang H, Kulas JA, Wang C, Holtzman DM, Ferris HA, Hansen SB (17 August 2021).
3172:"Synapse formation and function is modulated by the amyloid precursor protein"
3010:
2937:
2925:
2881:
2695:
2688:
2675:
2569:
2544:
2501:
2440:
751:
648:
598:
7112:
6720:
6687:
6079:
6062:
5897:
5848:
5831:
5807:
5790:
5713:
3618:
3435:
2729:
The most-substantiated role for APP is in synaptic formation and repair; its
7678:
7445:: Aqueous Solution Structure of the Alzheimer's Disease Abeta Peptide (1-42)
6763:
5664:
5647:
5195:
5109:
4835:
4352:
4100:
3781:
3384:
2933:
2769:
2679:
2663:
2548:
1950:
995:
873:
818:
805:
717:
704:
606:
7355:: Solution structure of the Alzheimer's disease amyloid beta-peptide (1-42)
7130:
7087:
7044:
7013:
6962:
6925:
6890:
6861:
6824:
6781:
6738:
6695:
6666:
6615:
6586:
6549:
6504:
6469:
6440:
6363:
6314:
6305:
6288:
6221:
6213:
6178:
6137:
6047:
6038:
6021:
5998:
5957:
5948:
5931:
5767:
5632:
5624:
5588:
5571:
5556:
5547:
5530:
5494:
5460:
5404:
5395:
5378:
5363:
5314:
5263:
5214:
5163:
5127:
5078:
5019:
4960:
4911:
4854:
4809:
Satpute-Krishnan P, DeGiorgis JA, Conley MP, Jang M, Bearer EL (Oct 2006).
4795:
4735:
4678:
4635:
4596:
4553:
4504:
4485:
4453:
4396:
4360:
4262:
4211:
4119:
4057:
3995:
3895:
3694:
3636:
3568:
3454:
3403:
3344:
3291:
3242:
3207:
6403:
6265:
6088:
6061:
Ikezu T, Trapp BD, Song KS, Schlegel A, Lisanti MP, Okamoto T (Apr 1998).
5989:
5972:
5916:
5857:
5816:
5732:
5673:
5597:
5512:
5245:
4754:"Somatic APP gene recombination in Alzheimer's disease and normal neurons"
4435:
4175:
3939:
3836:
3789:
3738:
3675:
3525:
3489:
2360:
2355:
7868:
5228:
Gallego MJ, Porayette P, Kaltcheva MM, Meethal SV, Atwood CS (Jun 2009).
3146:
3034:
3028:
2865:
2706:
2659:
2574:
2552:
2487:
2344:
2095:
2076:
4388:
4074:
Dahms SO, Hoefgen S, Roeser D, Schlott B, Gührs KH, Than ME (Mar 2010).
3987:
2559:
7844:
7630:
7146:
GeneReviews/NCBI/NIH/UW entry on Early-Onset Familial Alzheimer Disease
6772:
4942:
2829:
2818:
2817:. It has been found that APP can mediate interaction between cargo and
2694:
The amyloidogenic processing of APP has been linked to its presence in
2622:
2618:
2444:
2396:
2062:
2017:
6954:
6607:
6432:
4281:
4275:
4269:
4226:
4126:
4024:
3517:
539:
535:
531:
527:
523:
519:
515:
511:
507:
503:
499:
495:
491:
487:
483:
479:
475:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
411:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
367:
363:
359:
355:
351:
347:
343:
339:
335:
331:
327:
323:
319:
315:
311:
307:
303:
299:
295:
291:
287:
283:
279:
275:
271:
267:
263:
259:
255:
251:
247:
243:
239:
235:
231:
227:
223:
219:
215:
211:
207:
203:
199:
195:
191:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
83:
7795:
7668:
3931:
3828:
3730:
3049:
3004:
2993:
2987:
2981:
2794:
2598:
2540:
2512:
2400:
2328:
1972:
6287:
Tarr PE, Roncarati R, Pelicci G, Pelicci PG, D'Adamio L (May 2002).
2896:– with the differential processing of AβPP by secretases regulating
2658:
processing to generate peptide fragments. It is commonly cleaved by
2535:
5295:
7693:
6257:
3595:"Caenorhabditis elegans as a model organism to study APP function"
3022:
2975:
2969:
2963:
2957:
2786:
2612:
2558:
2534:
2468:
2371:
7265:: SOLUTION STRUCTURE OF RESIDUES 1-28 OF THE AMYLOID BETA-PEPTIDE
7250:: SOLUTION STRUCTURE OF RESIDUES 1-28 OF THE AMYLOID BETA-PEPTIDE
6815:
6746:
Watson D, Castaño E, Kokjohn TA, Kuo YM, Lyubchenko Y, Pinsky D,
4203:
2567:
and one of the most highly conserved regions of the protein from
1935:
1931:
1446:
regulation of epidermal growth factor-activated receptor activity
7058:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
6984:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
3266:"The antimicrobial protection hypothesis of Alzheimer's disease"
3040:
2999:
2869:
2483:
2472:
1881:
negative regulation of low-density lipoprotein receptor activity
1811:
positive regulation of DNA-binding transcription factor activity
586:
7594:
7325:: RELOCATING A NEGATIVE CHARGE IN THE BINDING POCKET OF TRYPSIN
7188:
7590:
7184:
4140:
Sisodia SS, Koo EH, Hoffman PN, Perry G, Price DL (Jul 1993).
1816:
positive regulation of NF-kappaB transcription factor activity
1040:
6631:
Maynard CJ, Bush AI, Masters CL, Cappai R, Li QX (Jun 2005).
4700:
Barger SW, DeWall KM, Liu L, Mrak RE, Griffin WS (Aug 2008).
4418:
Ehehalt R, Keller P, Haass C, Thiele C, Simons K (Jan 2003).
2912:(hCG) increases AβPP expression and hESC proliferation while
7280:: THE ALZHEIMER`S DISEASE AMYLOID A4 PEPTIDE (RESIDUES 1-40)
6567:
The International Journal of Biochemistry & Cell Biology
1586:
positive regulation of G2/M transition of mitotic cell cycle
2836:
moiety of peptides is not sufficient to mediate transport.
21:
Union des Producteurs Phonographiques Français Indépendants
5871:
Zheng P, Eastman J, Vande Pol S, Pimplikar SW (Dec 1998).
4518:
Riddell DR, Christie G, Hussain I, Dingwall C (Aug 2001).
2908:
into neural precursor cells (NPC). The pregnancy hormone
2573:
to humans. This domain, which resembles the structure of
2499:
proteins have been identified in other organisms such as
1741:
positive regulation of peptidyl-threonine phosphorylation
1651:
positive regulation of transcription by RNA polymerase II
2463:
Amyloid-beta precursor protein is an ancient and highly
842:
5789:
Trommsdorff M, Borg JP, Margolis B, Herz J (Dec 1998).
1856:
positive regulation of long-term synaptic potentiation
1851:
negative regulation of long-term synaptic potentiation
1766:
positive regulation of peptidyl-serine phosphorylation
5687:
Guénette SY, Chen J, Jondro PD, Tanzi RE (Oct 1996).
4610:
Phinney AL, Calhoun ME, Wolfer DP, Lipp HP, Zheng H,
4375:
gamma-secretase but not epsilon-secretase activity".
1007:
7370:: N-TERMINAL DOMAIN OF THE AMYLOID PRECURSOR PROTEIN
4706:
Journal of Neuropathology and Experimental Neurology
2427:. APP is best known as the precursor molecule whose
1791:
regulation of long-term neuronal synaptic plasticity
1721:
negative regulation of cell population proliferation
1526:
smooth endoplasmic reticulum calcium ion homeostasis
7835:
7812:
7794:
7766:
7752:
7743:
7702:
7628:
6202:
Biochemical and Biophysical Research Communications
5830:Chow N, Korenberg JR, Chen XN, Neve RL (May 1996).
5613:
Biochemical and Biophysical Research Communications
5144:
Biochemical and Biophysical Research Communications
2828:, controls were conjugated to a single amino acid,
2273:
2216:
2174:
2113:
3089:
3087:
3085:
3068:
3066:
3064:
1901:positive regulation of signaling receptor activity
7475:: 3D Structure of Alzheimer's Abeta(1-42) fibrils
6703:Reinhard C, Hébert SS, De Strooper B (Dec 2005).
2793:occurs frequently in the gene that encodes APP.
1871:positive regulation of microglial cell activation
1421:cellular response to nerve growth factor stimulus
789:
688:
6633:"Metals and amyloid-beta in Alzheimer's disease"
5423:Biederer T, Cao X, Südhof TC, Liu X (Sep 2002).
2709:are major risk factors for Alzheimer's disease.
1701:astrocyte activation involved in immune response
6877:Gallo C, Orlassino R, Vineis C (Feb 2006). "".
6637:International Journal of Experimental Pathology
6450:Annual Review of Cell and Developmental Biology
5971:Lefterov IM, Koldamova RP, Lazo JS (Sep 2000).
5524:
5522:
5477:Borg JP, Ooi J, Levy E, Margolis B (Nov 1996).
5418:
5416:
5414:
4747:
4745:
3659:"The amyloid precursor protein: beyond amyloid"
3364:Proceedings of the National Academy of Sciences
1891:positive regulation of amyloid fibril formation
1846:regulation of spontaneous synaptic transmission
1841:modulation of excitatory postsynaptic potential
1796:regulation of peptidyl-tyrosine phosphorylation
1511:ionotropic glutamate receptor signaling pathway
5472:
5470:
3094:GRCm38: Ensembl release 89: ENSMUSG00000022892
1861:positive regulation of NIK/NF-kappaB signaling
1696:positive regulation of protein phosphorylation
7606:
7200:
2539:The metal-binding domain of APP with a bound
1866:positive regulation of amyloid-beta formation
1656:negative regulation of endopeptidase activity
1431:negative regulation of neuron differentiation
8:
7052:Caltagarone J, Jing Z, Bowser R (Apr 2007).
6151:Ohsawa I, Takamura C, Kohsaka S (Mar 2001).
5092:McCarthy RC, Park YH, Kosman DJ (Jul 2014).
4974:Ebrahimi KH, Hagedoorn PL, Hagen WR (2012).
4293:
4291:
2948:Amyloid precursor protein has been shown to
1826:positive regulation of ERK1 and ERK2 cascade
1706:G protein-coupled receptor signaling pathway
1561:cellular response to norepinephrine stimulus
1129:serine-type endopeptidase inhibitor activity
3073:GRCh38: Ensembl release 89: ENSG00000142192
1821:positive regulation of astrocyte activation
1686:defense response to Gram-positive bacterium
1681:defense response to Gram-negative bacterium
1641:regulation of synapse structure or activity
1611:regulation of multicellular organism growth
1531:synaptic assembly at neuromuscular junction
7749:
7613:
7599:
7591:
7207:
7193:
7185:
6522:Annals of the New York Academy of Sciences
6384:Annals of the New York Academy of Sciences
2719:Experimental models of Alzheimer's disease
2407:and has been implicated as a regulator of
2213:
2110:
1946:
1335:COPII-coated ER to Golgi transport vesicle
1056:
830:
729:
626:
72:
7153:at the U.S. National Library of Medicine
7120:
7077:
7003:
6915:
6814:
6771:
6728:
6656:
6494:
6353:
6304:
6168:
6127:
6078:
6037:
5988:
5947:
5906:
5896:
5847:
5806:
5722:
5712:
5663:
5587:
5546:
5502:
5450:
5440:
5394:
5353:
5304:
5294:
5253:
5204:
5194:
5117:
5068:
5058:
5009:
4999:
4950:
4901:
4844:
4834:
4785:
4725:
4543:
4494:
4484:
4443:
4323:
4165:
4109:
4099:
4047:
4015:
4013:
3885:
3875:
3684:
3674:
3626:
3444:
3434:
3393:
3383:
3334:
3281:
3197:
3187:
3165:
3163:
1921:positive regulation of glycolytic process
1621:positive regulation of peptidase activity
1521:negative regulation of peptidase activity
1506:collateral sprouting in absence of injury
1486:positive regulation of mitotic cell cycle
1436:neuromuscular process controlling balance
6462:10.1146/annurev.cellbio.18.020402.142302
4069:
4067:
3652:
3650:
3648:
3646:
7340:: BOVINE CHYMOTRYPSIN COMPLEXED TO APPI
7222:
3060:
2563:The extracellular E2 domain, a dimeric
1911:positive regulation of T cell migration
1776:post-translational protein modification
4589:10.1146/annurev.neuro.26.041002.131334
3303:
3301:
2678:fragments that may be associated with
1771:positive regulation of phosphorylation
1756:positive regulation of protein binding
1736:negative regulation of gene expression
1731:positive regulation of gene expression
27:
7781:ACys+ABri/Cerebral amyloid angiopathy
7735:ATTR/Transthyretin-related hereditary
2768:are viable and have relatively minor
1591:axon midline choice point recognition
1320:integral component of plasma membrane
1144:signaling receptor activator activity
794:
755:
750:
693:
652:
647:
7:
3864:Acta Neuropathologica Communications
2932:, the adult equivalent of hCG, post-
1906:regulation of NMDA receptor activity
978:vestibular membrane of cochlear duct
6293:The Journal of Biological Chemistry
6067:The Journal of Biological Chemistry
6026:The Journal of Biological Chemistry
5936:The Journal of Biological Chemistry
5836:The Journal of Biological Chemistry
5795:The Journal of Biological Chemistry
5652:The Journal of Biological Chemistry
5576:The Journal of Biological Chemistry
5535:The Journal of Biological Chemistry
5383:The Journal of Biological Chemistry
5183:The Journal of Biological Chemistry
4473:The Journal of Biological Chemistry
3962:Watts RJ, Stefansson K (Aug 2012).
3264:Moir RD, Lathe R, Tanzi RE (2018).
1751:regulation of Wnt signaling pathway
7914:Single-pass transmembrane proteins
7415:: BOVINE TRYPSIN COMPLEXED TO APPI
6854:10.1212/01.wnl.0000192107.17175.39
6542:10.1111/j.1749-6632.2002.tb04824.x
6396:10.1111/j.1749-6632.1993.tb23035.x
5442:10.1523/JNEUROSCI.22-17-07340.2002
5346:10.1523/JNEUROSCI.23-17-06914.2003
4158:10.1523/JNEUROSCI.13-07-03136.1993
3417:Tharp WG, Sarkar IN (April 2013).
2741:and after neural injury. Roles in
2270:
2171:
2086:
2067:
2041:
2022:
1996:
1977:
1836:cellular response to manganese ion
1781:positive regulation of JNK cascade
1012:
954:choroid plexus of fourth ventricle
930:
868:
847:
14:
2588:A number of different structural
2447:form is the primary component of
1886:regulation of presynapse assembly
1876:cellular response to amyloid-beta
1546:extracellular matrix organization
16:Mammalian protein found in humans
7570:
7555:
7540:
7525:
7510:
7495:
7480:
7465:
7450:
7435:
7420:
7405:
7390:
7375:
7360:
7345:
7330:
7315:
7300:
7285:
7270:
7255:
7240:
7225:
6917:10.1111/j.1471-4159.2006.03905.x
6649:10.1111/j.0959-9673.2005.00434.x
6596:Journal of Neuroscience Research
6496:10.1034/j.1600-0854.2002.31101.x
6170:10.1046/j.1471-4159.2001.00144.x
5283:Stem Cell Research & Therapy
4931:Biochemical Society Transactions
3147:"Amyloid-beta precursor protein"
1761:tumor necrosis factor production
1030:
1023:
1016:
778:
771:
765:
742:
677:
670:
664:
639:
36:
7804:AApoA1+AFib+ALys/Familial renal
7730:AA/Familial Mediterranean fever
6978:Neve RL, McPhie DL (Apr 2007).
2797:from individuals with sporadic
2636:post-translational modification
1831:cellular response to copper ion
1451:cellular copper ion homeostasis
1360:perinuclear region of cytoplasm
6346:10.1523/JNEUROSCI.4872-08.2009
5483:Molecular and Cellular Biology
3561:10.1016/j.brainres.2007.05.050
3189:10.1523/JNEUROSCI.1450-06.2006
2862:single nucleotide polymorphism
2809:Anterograde neuronal transport
2419:. It is coded for by the gene
2415:, antimicrobial activity, and
2381:Amyloid-beta precursor protein
1666:antibacterial humoral response
1255:integral component of membrane
1119:growth factor receptor binding
1084:acetylcholine receptor binding
1041:More reference expression data
996:More reference expression data
1:
7850:ACal/Medullary thyroid cancer
7822:Primary cutaneous amyloidosis
7720:Aβ2M/Haemodialysis-associated
6579:10.1016/S1357-2725(03)00133-X
6421:Accounts of Chemical Research
5760:10.1016/S0304-3940(98)00995-1
4628:10.1016/S0306-4522(98)00645-9
4577:Annual Review of Neuroscience
4545:10.1016/S0960-9822(01)00394-3
3235:10.1016/S0301-0082(03)00089-3
2894:endocrinology of reproduction
2872:can disrupt its translation.
2725:Synaptic formation and repair
2630:Post-translational processing
2625:derived post-mitotic neurons.
1896:neuron projection maintenance
1631:regulation of protein binding
1581:regulation of gene expression
1551:cholesterol metabolic process
1456:neuron projection development
970:vestibular sensory epithelium
763:
662:
7904:Genes on human chromosome 21
7070:10.1016/j.bbadis.2006.11.007
6996:10.1016/j.bbadis.2006.10.008
5060:10.1371/journal.pone.0072177
5001:10.1371/journal.pone.0040287
4894:10.1088/1478-3975/9/5/055005
4718:10.1097/NEN.0b013e318180ec47
4671:10.1097/WNR.0b013e3281e72b18
4243:Journal of Molecular Biology
4049:10.1016/j.molcel.2004.06.037
3482:10.1016/0378-1119(90)90310-N
2910:human chorionic gonadotropin
1496:response to oxidative stress
1330:smooth endoplasmic reticulum
1315:platelet alpha granule lumen
1175:trans-Golgi network membrane
1139:transition metal ion binding
1104:peptidase inhibitor activity
1099:peptidase activator activity
920:Epithelium of choroid plexus
7776:Familial amyloid neuropathy
6943:Neuro-Degenerative Diseases
6676:Protein and Peptide Letters
6334:The Journal of Neuroscience
5429:The Journal of Neuroscience
5334:The Journal of Neuroscience
4424:The Journal of Cell Biology
4146:The Journal of Neuroscience
3663:Molecular Neurodegeneration
3599:Experimental Brain Research
3283:10.1016/j.jalz.2018.06.3040
3176:The Journal of Neuroscience
2654:, as well as many types of
1671:antifungal humoral response
1370:endoplasmic reticulum lumen
1215:rough endoplasmic reticulum
982:nucleus of stria terminalis
900:stromal cell of endometrium
7945:
7177:gene details page in the
7037:10.2174/156720506779025215
7024:Current Alzheimer Research
6390:(1 Transduction): 91–102.
5234:Stem Cells and Development
5156:10.1016/j.bbrc.2007.10.021
4316:10.1038/s41598-024-63005-y
3327:10.1016/j.cell.2010.08.014
3270:Alzheimer's & Dementia
2815:fast anterograde transport
1566:nervous system development
1079:signaling receptor binding
18:
7745:Organ-limited amyloidosis
7220:
7151:Amyloid+Protein+Precursor
6904:Journal of Neurochemistry
6157:Journal of Neurochemistry
4778:10.1038/s41586-018-0718-6
4255:10.1016/j.jmb.2006.12.041
4192:Nature Structural Biology
4030:Wang Y, Ha Y (Aug 2004).
3877:10.1186/s40478-020-0891-3
3611:10.1007/s00221-011-2905-7
3129:"Mouse PubMed Reference:"
3111:"Human PubMed Reference:"
2898:human embryonic stem cell
2856:through interaction with
2595:growth factor-like domain
2389:integral membrane protein
2359:
2354:
2350:
2343:
2327:
2308:
2277:
2240:
2209:
2178:
2137:
2106:
2093:
2089:
2074:
2070:
2061:
2048:
2044:
2029:
2025:
2016:
2003:
1999:
1984:
1980:
1971:
1956:
1949:
1945:
1929:
1916:response to interleukin-1
1636:regulation of translation
1481:adult locomotory behavior
1461:cellular response to cAMP
1295:growth cone lamellipodium
1134:identical protein binding
1059:
1055:
1038:
1015:
1006:
993:
942:
933:
880:
871:
841:
833:
829:
812:
799:
762:
741:
732:
728:
711:
698:
661:
638:
629:
625:
580:
577:
567:
560:
555:
80:
75:
58:
53:
48:
44:
35:
30:
7155:Medical Subject Headings
7113:10.1038/sj.embor.7400896
6721:10.1038/sj.emboj.7600860
6688:10.2174/0929866054395905
6080:10.1074/jbc.273.17.10485
5898:10.1073/pnas.95.25.14745
5849:10.1074/jbc.271.19.11339
5808:10.1074/jbc.273.50.33556
5714:10.1073/pnas.93.20.10832
4267:; See also 2007 PDB IDs
3657:Zheng H, Koo EH (2006).
3436:10.1186/1471-2164-14-290
3223:Progress in Neurobiology
2785:In neurons of the human
2634:APP undergoes extensive
2395:and concentrated in the
2321:Chr 16: 84.75 – 84.97 Mb
2314:Chr 21: 25.88 – 26.17 Mb
1691:neuron apoptotic process
1426:amyloid fibril formation
1375:Golgi-associated vesicle
904:tendon of biceps brachii
896:internal globus pallidus
796:16 C3.3|16 46.92 cM
7400:: human APP core domain
6898:Coulson EJ (Aug 2006).
6803:Frontiers in Bioscience
6764:10.1179/016164105X49436
6120:10.1093/emboj/21.7.1524
5665:10.1074/jbc.272.10.6399
5196:10.1074/jbc.M109.026328
5110:10.15252/embr.201338064
4836:10.1073/pnas.0607527103
4353:10.1242/jcs.113.11.1857
4341:Journal of Cell Science
4101:10.1073/pnas.0911326107
3782:10.1126/science.1925564
3385:10.1073/pnas.2102191118
2451:found in the brains of
1516:Notch signaling pathway
1491:axo-dendritic transport
1441:protein phosphorylation
1390:presynaptic active zone
7786:Aβ/Alzheimer's disease
6306:10.1074/jbc.M110286200
6214:10.1006/bbrc.1999.0623
6039:10.1074/jbc.M401925200
5949:10.1074/jbc.M209684200
5625:10.1006/bbrc.1999.0265
5589:10.1074/jbc.274.4.2243
5548:10.1074/jbc.M306024200
5495:10.1128/mcb.16.11.6229
5396:10.1074/jbc.M311993200
4486:10.1074/jbc.M407986200
3419:"Origins of amyloid-β"
2747:long-term potentiation
2626:
2585:
2556:
2519:biological functions.
2511:(roundworms), and all
2425:substrate presentation
2377:
1676:innate immune response
1616:platelet degranulation
1340:growth cone filopodium
1305:nuclear envelope lumen
1270:neuromuscular junction
7095:Wolfe MS (Feb 2007).
6848:(2 Suppl 1): S69–73.
6752:Neurological Research
5990:10.1096/fj.99-0938com
5246:10.1089/scd.2008.0190
4436:10.1083/jcb.200207113
3676:10.1186/1750-1326-1-5
3593:, Li C (2012-04-01).
2791:somatic recombination
2781:Somatic recombination
2616:
2577:, is thought to bind
2562:
2538:
2405:cell surface receptor
2375:
1746:microglia development
1726:response to radiation
1626:forebrain development
1250:extracellular exosome
908:primary visual cortex
757:Chromosome 16 (mouse)
655:Chromosome 21 (human)
7760:AANF/Isolated atrial
7703:Systemic amyloidosis
7171:genome location and
5748:Neuroscience Letters
2848:activity similar to
2492:alternative splicing
2439:containing 37 to 49
2403:. It functions as a
1801:synapse organization
1786:astrocyte activation
1576:response to lead ion
1541:dendrite development
1501:mRNA polyadenylation
1290:astrocyte projection
1195:extracellular region
76:List of PDB id codes
49:Available structures
7909:Alzheimer's disease
7179:UCSC Genome Browser
6534:2002NYASA.977..258N
6477:Koo EH (Nov 2002).
6250:1997Natur.389..689D
5889:1998PNAS...9514745Z
5705:1996PNAS...9310832G
5051:2013PLoSO...872177H
4992:2012PLoSO...740287E
4886:2012PhBio...9e5005S
4827:2006PNAS..10316532S
4770:2018Natur.563..639L
4536:2001CBio...11.1288R
4389:10.1038/nature04667
4092:2010PNAS..107.5381D
3988:10.1038/nature11283
3980:2012Natur.488...96J
3924:1992Natur.360..672C
3821:1991Natur.353..844C
3774:1991Sci...254...97M
3723:1991Natur.349..704G
3376:2021PNAS..11802191W
3370:(33): e2102191118.
3048:APP interacts with
2930:luteinizing hormone
2888:Hormonal regulation
2799:Alzheimer's disease
2713:Biological function
2453:Alzheimer's disease
1476:locomotory behavior
1350:extracellular space
1345:cytoplasmic vesicle
1310:clathrin-coated pit
1285:apical part of cell
916:islet of Langerhans
7929:Precursor proteins
4943:10.1042/BST0361282
4304:Scientific Reports
4224:; see also PDB ID
4124:; see also PDB ID
2652:tyrosine sulfation
2627:
2586:
2557:
2523:production of Aβ.
2391:expressed in many
2378:
2051:ENSMUSG00000022892
1711:learning or memory
1414:Biological process
1395:recycling endosome
1185:cell-cell junction
1153:Cellular component
1124:PTB domain binding
1067:Molecular function
7891:
7890:
7887:
7886:
7862:APro/Prolactinoma
7725:AGel/Finnish type
7588:
7587:
6955:10.1159/000092315
6715:(23): 3996–4006.
6608:10.1002/jnr.20408
6433:10.1021/ar010031e
6299:(19): 16798–804.
4764:(7733): 639–645.
4383:(7088): 1208–12.
3518:10.1038/ng0993-22
3276:(12): 1602–1614.
2904:as well as their
2605:Isoform diversity
2465:conserved protein
2445:amyloid fibrillar
2423:and regulated by
2413:neural plasticity
2409:synapse formation
2370:
2369:
2366:
2365:
2339:
2338:
2304:
2303:
2267:
2266:
2205:
2204:
2168:
2167:
2102:
2101:
2083:
2082:
2057:
2056:
2038:
2037:
2012:
2011:
1993:
1992:
1941:
1940:
1661:response to yeast
1536:neuron remodeling
1471:apoptotic process
1466:suckling behavior
1210:neuron projection
1089:metal ion binding
1051:
1050:
1047:
1046:
1002:
1001:
989:
988:
962:perirhinal cortex
958:entorhinal cortex
927:
926:
884:prefrontal cortex
825:
824:
724:
723:
551:
550:
547:
546:
59:Ortholog search:
7936:
7874:AIAPP/Insulinoma
7750:
7633:forming proteins
7615:
7608:
7601:
7592:
7574:
7559:
7544:
7529:
7514:
7499:
7484:
7469:
7454:
7439:
7424:
7409:
7394:
7379:
7364:
7349:
7334:
7319:
7304:
7289:
7274:
7259:
7244:
7229:
7209:
7202:
7195:
7186:
7134:
7124:
7091:
7081:
7048:
7017:
7007:
6974:
6937:
6919:
6894:
6873:
6836:
6818:
6793:
6775:
6742:
6732:
6709:The EMBO Journal
6699:
6670:
6660:
6627:
6590:
6561:
6516:
6498:
6473:
6444:
6415:
6368:
6367:
6357:
6325:
6319:
6318:
6308:
6284:
6278:
6277:
6244:(6652): 689–95.
6232:
6226:
6225:
6197:
6191:
6190:
6172:
6148:
6142:
6141:
6131:
6108:The EMBO Journal
6099:
6093:
6092:
6082:
6073:(17): 10485–95.
6058:
6052:
6051:
6041:
6032:(23): 24343–54.
6017:
6011:
6010:
5992:
5968:
5962:
5961:
5951:
5927:
5921:
5920:
5910:
5900:
5883:(25): 14745–50.
5868:
5862:
5861:
5851:
5842:(19): 11339–46.
5827:
5821:
5820:
5810:
5801:(50): 33556–60.
5786:
5780:
5779:
5743:
5737:
5736:
5726:
5716:
5684:
5678:
5677:
5667:
5658:(10): 6399–405.
5643:
5637:
5636:
5608:
5602:
5601:
5591:
5567:
5561:
5560:
5550:
5541:(49): 49448–58.
5526:
5517:
5516:
5506:
5474:
5465:
5464:
5454:
5444:
5420:
5409:
5408:
5398:
5389:(19): 20539–45.
5374:
5368:
5367:
5357:
5325:
5319:
5318:
5308:
5298:
5274:
5268:
5267:
5257:
5225:
5219:
5218:
5208:
5198:
5189:(35): 23806–17.
5174:
5168:
5167:
5138:
5132:
5131:
5121:
5089:
5083:
5082:
5072:
5062:
5030:
5024:
5023:
5013:
5003:
4971:
4965:
4964:
4954:
4937:(Pt 6): 1282–7.
4922:
4916:
4915:
4905:
4874:Physical Biology
4865:
4859:
4858:
4848:
4838:
4806:
4800:
4799:
4789:
4749:
4740:
4739:
4729:
4697:
4691:
4690:
4654:
4648:
4647:
4607:
4601:
4600:
4572:
4566:
4565:
4547:
4515:
4509:
4508:
4498:
4488:
4479:(43): 44945–54.
4464:
4458:
4457:
4447:
4415:
4409:
4408:
4371:
4365:
4364:
4336:
4330:
4329:
4327:
4295:
4286:
4284:
4278:
4272:
4266:
4237:
4231:
4229:
4223:
4186:
4180:
4179:
4169:
4137:
4131:
4129:
4123:
4113:
4103:
4071:
4062:
4061:
4051:
4027:
4017:
4008:
4007:
3958:
3952:
3951:
3932:10.1038/360672a0
3906:
3900:
3899:
3889:
3879:
3855:
3849:
3848:
3829:10.1038/353844a0
3800:
3794:
3793:
3757:
3751:
3750:
3731:10.1038/349704a0
3705:
3699:
3698:
3688:
3678:
3654:
3641:
3640:
3630:
3605:(3–4): 397–411.
3587:
3581:
3580:
3544:
3538:
3537:
3500:
3494:
3493:
3465:
3459:
3458:
3448:
3438:
3414:
3408:
3407:
3397:
3387:
3355:
3349:
3348:
3338:
3305:
3296:
3295:
3285:
3261:
3255:
3254:
3218:
3212:
3211:
3201:
3191:
3167:
3158:
3157:
3155:
3153:
3143:
3137:
3136:
3125:
3119:
3118:
3107:
3101:
3091:
3080:
3070:
2737:during neuronal
2704:apolipoprotein E
2676:carboxy-terminal
2482:and contains 18
2443:residues, whose
2352:
2351:
2323:
2316:
2299:
2271:
2262:
2214:
2210:RefSeq (protein)
2200:
2172:
2163:
2111:
2087:
2068:
2042:
2023:
1997:
1978:
1947:
1646:cellular process
1405:synaptic vesicle
1275:receptor complex
1057:
1043:
1034:
1027:
1020:
1013:
998:
938:
936:Top expressed in
931:
876:
874:Top expressed in
869:
848:
831:
821:
808:
797:
782:
775:
769:
758:
746:
730:
720:
707:
696:
681:
674:
668:
657:
643:
627:
621:
572:
565:
542:
73:
67:
46:
45:
40:
28:
7944:
7943:
7939:
7938:
7937:
7935:
7934:
7933:
7894:
7893:
7892:
7883:
7879:Type 2 diabetes
7831:
7827:Amyloid purpura
7808:
7790:
7762:
7739:
7698:
7624:
7619:
7589:
7584:
7581:
7575:
7566:
7560:
7551:
7545:
7536:
7530:
7521:
7515:
7506:
7500:
7491:
7485:
7476:
7470:
7461:
7455:
7446:
7440:
7431:
7425:
7416:
7410:
7401:
7395:
7386:
7380:
7371:
7365:
7356:
7350:
7341:
7335:
7326:
7320:
7311:
7305:
7296:
7290:
7281:
7275:
7266:
7260:
7251:
7245:
7236:
7230:
7216:
7213:
7142:
7137:
7094:
7051:
7020:
6977:
6940:
6897:
6876:
6839:
6796:
6745:
6702:
6673:
6630:
6593:
6573:(11): 1505–35.
6564:
6519:
6476:
6447:
6418:
6380:
6376:
6374:Further reading
6371:
6340:(23): 7459–73.
6327:
6326:
6322:
6286:
6285:
6281:
6234:
6233:
6229:
6199:
6198:
6194:
6150:
6149:
6145:
6101:
6100:
6096:
6060:
6059:
6055:
6019:
6018:
6014:
5983:(12): 1837–47.
5970:
5969:
5965:
5942:(16): 14461–8.
5929:
5928:
5924:
5870:
5869:
5865:
5829:
5828:
5824:
5788:
5787:
5783:
5745:
5744:
5740:
5699:(20): 10832–7.
5686:
5685:
5681:
5645:
5644:
5640:
5610:
5609:
5605:
5569:
5568:
5564:
5528:
5527:
5520:
5489:(11): 6229–41.
5476:
5475:
5468:
5435:(17): 7340–51.
5422:
5421:
5412:
5376:
5375:
5371:
5340:(17): 6914–27.
5327:
5326:
5322:
5276:
5275:
5271:
5227:
5226:
5222:
5176:
5175:
5171:
5140:
5139:
5135:
5091:
5090:
5086:
5032:
5031:
5027:
4973:
4972:
4968:
4924:
4923:
4919:
4867:
4866:
4862:
4821:(44): 16532–7.
4808:
4807:
4803:
4751:
4750:
4743:
4699:
4698:
4694:
4656:
4655:
4651:
4609:
4608:
4604:
4574:
4573:
4569:
4530:(16): 1288–93.
4524:Current Biology
4517:
4516:
4512:
4466:
4465:
4461:
4417:
4416:
4412:
4373:
4372:
4368:
4347:(11): 1857–70.
4338:
4337:
4333:
4297:
4296:
4289:
4280:
4274:
4268:
4239:
4238:
4234:
4225:
4188:
4187:
4183:
4139:
4138:
4134:
4125:
4073:
4072:
4065:
4029:
4019:
4018:
4011:
3960:
3959:
3955:
3918:(6405): 672–4.
3908:
3907:
3903:
3857:
3856:
3852:
3815:(6347): 844–6.
3802:
3801:
3797:
3759:
3758:
3754:
3717:(6311): 704–6.
3707:
3706:
3702:
3656:
3655:
3644:
3589:
3588:
3584:
3546:
3545:
3541:
3506:Nature Genetics
3502:
3501:
3497:
3467:
3466:
3462:
3416:
3415:
3411:
3357:
3356:
3352:
3307:
3306:
3299:
3263:
3262:
3258:
3220:
3219:
3215:
3182:(27): 7212–21.
3169:
3168:
3161:
3151:
3149:
3145:
3144:
3140:
3127:
3126:
3122:
3109:
3108:
3104:
3092:
3083:
3071:
3062:
3058:
3046:
2946:
2906:differentiation
2890:
2852:, facilitating
2842:
2811:
2783:
2739:differentiation
2727:
2715:
2684:gamma secretase
2668:alpha secretase
2644:phosphorylation
2632:
2607:
2579:heparan sulfate
2533:
2505:(fruit flies),
2461:
2449:amyloid plaques
2361:View/Edit Mouse
2356:View/Edit Human
2319:
2312:
2309:Location (UCSC)
2295:
2291:
2287:
2283:
2279:
2258:
2254:
2250:
2246:
2242:
2236:
2232:
2228:
2224:
2220:
2196:
2192:
2188:
2184:
2180:
2159:
2155:
2151:
2147:
2143:
2139:
2133:
2129:
2125:
2121:
2117:
2032:ENSG00000142192
1925:
1596:visual learning
1556:mating behavior
1409:
1380:cell projection
1280:plasma membrane
1260:Golgi apparatus
1240:terminal bouton
1230:dendritic shaft
1220:dendritic spine
1205:spindle midzone
1200:ciliary rootlet
1148:
1109:protein binding
1074:heparin binding
1039:
1029:
1028:
1022:
1021:
994:
985:
980:
976:
974:cingulate gyrus
972:
968:
964:
960:
956:
952:
948:
934:
923:
918:
914:
910:
906:
902:
898:
894:
890:
888:Brodmann area 9
886:
872:
816:
803:
795:
785:
784:
783:
776:
756:
733:Gene location (
715:
702:
694:
684:
683:
682:
675:
653:
630:Gene location (
619:APP - orthologs
581:
568:
561:
82:
60:
24:
17:
12:
11:
5:
7942:
7940:
7932:
7931:
7926:
7921:
7919:Neurochemistry
7916:
7911:
7906:
7896:
7895:
7889:
7888:
7885:
7884:
7882:
7881:
7876:
7871:
7865:
7864:
7859:
7853:
7852:
7847:
7841:
7839:
7833:
7832:
7830:
7829:
7824:
7818:
7816:
7810:
7809:
7807:
7806:
7800:
7798:
7792:
7791:
7789:
7788:
7783:
7778:
7772:
7770:
7764:
7763:
7758:
7756:
7747:
7741:
7740:
7738:
7737:
7732:
7727:
7722:
7717:
7715:AA amyloidosis
7712:
7710:AL amyloidosis
7706:
7704:
7700:
7699:
7697:
7696:
7691:
7686:
7681:
7676:
7671:
7666:
7657:
7652:
7647:
7642:
7636:
7634:
7626:
7625:
7620:
7618:
7617:
7610:
7603:
7595:
7586:
7585:
7583:
7582:
7576:
7569:
7567:
7561:
7554:
7552:
7546:
7539:
7537:
7531:
7524:
7522:
7516:
7509:
7507:
7501:
7494:
7492:
7486:
7479:
7477:
7471:
7464:
7462:
7456:
7449:
7447:
7441:
7434:
7432:
7426:
7419:
7417:
7411:
7404:
7402:
7396:
7389:
7387:
7381:
7374:
7372:
7366:
7359:
7357:
7351:
7344:
7342:
7336:
7329:
7327:
7321:
7314:
7312:
7306:
7299:
7297:
7291:
7284:
7282:
7276:
7269:
7267:
7261:
7254:
7252:
7246:
7239:
7237:
7231:
7224:
7221:
7218:
7217:
7214:
7212:
7211:
7204:
7197:
7189:
7183:
7182:
7163:
7158:
7148:
7141:
7140:External links
7138:
7136:
7135:
7092:
7049:
7018:
6975:
6938:
6895:
6874:
6837:
6809:(1): 1646–66.
6794:
6743:
6700:
6671:
6628:
6591:
6562:
6517:
6489:(11): 763–70.
6474:
6445:
6416:
6377:
6375:
6372:
6370:
6369:
6320:
6279:
6227:
6192:
6163:(5): 1411–20.
6143:
6114:(7): 1524–34.
6094:
6053:
6012:
5963:
5922:
5863:
5822:
5781:
5738:
5679:
5638:
5603:
5582:(4): 2243–54.
5562:
5518:
5466:
5410:
5369:
5320:
5296:10.1186/scrt28
5269:
5220:
5169:
5133:
5084:
5025:
4966:
4917:
4860:
4801:
4741:
4692:
4665:(10): 1083–7.
4649:
4622:(4): 1207–16.
4602:
4567:
4510:
4459:
4410:
4366:
4331:
4287:
4232:
4181:
4152:(7): 3136–42.
4132:
4086:(12): 5381–6.
4063:
4036:Molecular Cell
4009:
3974:(7409): 96–9.
3953:
3901:
3850:
3795:
3768:(5028): 97–9.
3752:
3700:
3642:
3582:
3549:Brain Research
3539:
3495:
3460:
3409:
3350:
3297:
3256:
3213:
3159:
3138:
3120:
3102:
3081:
3059:
3057:
3054:
3045:
3044:
3038:
3032:
3026:
3020:
3014:
3008:
3002:
2997:
2991:
2985:
2979:
2973:
2967:
2961:
2954:
2945:
2942:
2889:
2886:
2841:
2838:
2810:
2807:
2782:
2779:
2743:cell signaling
2726:
2723:
2714:
2711:
2682:. Cleavage by
2672:beta secretase
2631:
2628:
2606:
2603:
2532:
2529:
2478:is located on
2460:
2457:
2368:
2367:
2364:
2363:
2358:
2348:
2347:
2341:
2340:
2337:
2336:
2334:
2332:
2325:
2324:
2317:
2310:
2306:
2305:
2302:
2301:
2275:
2274:
2268:
2265:
2264:
2238:
2237:
2211:
2207:
2206:
2203:
2202:
2176:
2175:
2169:
2166:
2165:
2135:
2134:
2108:
2104:
2103:
2100:
2099:
2091:
2090:
2084:
2081:
2080:
2072:
2071:
2065:
2059:
2058:
2055:
2054:
2046:
2045:
2039:
2036:
2035:
2027:
2026:
2020:
2014:
2013:
2010:
2009:
2001:
2000:
1994:
1991:
1990:
1982:
1981:
1975:
1969:
1968:
1963:
1958:
1954:
1953:
1943:
1942:
1939:
1938:
1927:
1926:
1924:
1923:
1918:
1913:
1908:
1903:
1898:
1893:
1888:
1883:
1878:
1873:
1868:
1863:
1858:
1853:
1848:
1843:
1838:
1833:
1828:
1823:
1818:
1813:
1808:
1803:
1798:
1793:
1788:
1783:
1778:
1773:
1768:
1763:
1758:
1753:
1748:
1743:
1738:
1733:
1728:
1723:
1718:
1713:
1708:
1703:
1698:
1693:
1688:
1683:
1678:
1673:
1668:
1663:
1658:
1653:
1648:
1643:
1638:
1633:
1628:
1623:
1618:
1613:
1608:
1603:
1598:
1593:
1588:
1583:
1578:
1573:
1568:
1563:
1558:
1553:
1548:
1543:
1538:
1533:
1528:
1523:
1518:
1513:
1508:
1503:
1498:
1493:
1488:
1483:
1478:
1473:
1468:
1463:
1458:
1453:
1448:
1443:
1438:
1433:
1428:
1423:
1417:
1415:
1411:
1410:
1408:
1407:
1402:
1397:
1392:
1387:
1382:
1377:
1372:
1367:
1365:early endosome
1362:
1357:
1352:
1347:
1342:
1337:
1332:
1327:
1322:
1317:
1312:
1307:
1302:
1297:
1292:
1287:
1282:
1277:
1272:
1267:
1262:
1257:
1252:
1247:
1242:
1237:
1232:
1227:
1225:endosome lumen
1222:
1217:
1212:
1207:
1202:
1197:
1192:
1187:
1182:
1177:
1172:
1167:
1162:
1156:
1154:
1150:
1149:
1147:
1146:
1141:
1136:
1131:
1126:
1121:
1116:
1111:
1106:
1101:
1096:
1094:enzyme binding
1091:
1086:
1081:
1076:
1070:
1068:
1064:
1063:
1053:
1052:
1049:
1048:
1045:
1044:
1036:
1035:
1010:
1004:
1003:
1000:
999:
991:
990:
987:
986:
984:
983:
979:
975:
971:
967:
963:
959:
955:
951:
947:
943:
940:
939:
928:
925:
924:
922:
921:
917:
913:
909:
905:
901:
897:
893:
889:
885:
881:
878:
877:
865:
864:
856:
845:
839:
838:
835:RNA expression
827:
826:
823:
822:
814:
810:
809:
801:
798:
793:
787:
786:
777:
770:
764:
760:
759:
754:
748:
747:
739:
738:
726:
725:
722:
721:
713:
709:
708:
700:
697:
692:
686:
685:
676:
669:
663:
659:
658:
651:
645:
644:
636:
635:
623:
622:
579:
575:
574:
566:
558:
557:
553:
552:
549:
548:
545:
544:
78:
77:
69:
68:
57:
51:
50:
42:
41:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
7941:
7930:
7927:
7925:
7922:
7920:
7917:
7915:
7912:
7910:
7907:
7905:
7902:
7901:
7899:
7880:
7877:
7875:
7872:
7870:
7867:
7866:
7863:
7860:
7858:
7855:
7854:
7851:
7848:
7846:
7843:
7842:
7840:
7838:
7834:
7828:
7825:
7823:
7820:
7819:
7817:
7815:
7811:
7805:
7802:
7801:
7799:
7797:
7793:
7787:
7784:
7782:
7779:
7777:
7774:
7773:
7771:
7769:
7765:
7761:
7757:
7755:
7751:
7748:
7746:
7742:
7736:
7733:
7731:
7728:
7726:
7723:
7721:
7718:
7716:
7713:
7711:
7708:
7707:
7705:
7701:
7695:
7692:
7690:
7687:
7685:
7682:
7680:
7677:
7675:
7672:
7670:
7667:
7665:
7661:
7658:
7656:
7653:
7651:
7648:
7646:
7643:
7641:
7638:
7637:
7635:
7632:
7627:
7623:
7616:
7611:
7609:
7604:
7602:
7597:
7596:
7593:
7579:
7573:
7568:
7564:
7558:
7553:
7549:
7543:
7538:
7534:
7528:
7523:
7519:
7513:
7508:
7504:
7498:
7493:
7489:
7483:
7478:
7474:
7468:
7463:
7459:
7453:
7448:
7444:
7438:
7433:
7429:
7423:
7418:
7414:
7408:
7403:
7399:
7393:
7388:
7384:
7378:
7373:
7369:
7363:
7358:
7354:
7348:
7343:
7339:
7333:
7328:
7324:
7318:
7313:
7309:
7303:
7298:
7294:
7288:
7283:
7279:
7273:
7268:
7264:
7258:
7253:
7249:
7243:
7238:
7234:
7228:
7223:
7219:
7210:
7205:
7203:
7198:
7196:
7191:
7190:
7187:
7180:
7176:
7175:
7170:
7169:
7164:
7162:
7159:
7156:
7152:
7149:
7147:
7144:
7143:
7139:
7132:
7128:
7123:
7118:
7114:
7110:
7107:(2): 136–40.
7106:
7102:
7098:
7093:
7089:
7085:
7080:
7075:
7071:
7067:
7064:(4): 438–45.
7063:
7059:
7055:
7050:
7046:
7042:
7038:
7034:
7031:(5): 515–20.
7030:
7026:
7025:
7019:
7015:
7011:
7006:
7001:
6997:
6993:
6989:
6985:
6981:
6976:
6972:
6968:
6964:
6960:
6956:
6952:
6949:(6): 277–83.
6948:
6944:
6939:
6935:
6931:
6927:
6923:
6918:
6913:
6910:(3): 654–60.
6909:
6905:
6901:
6896:
6892:
6888:
6884:
6880:
6875:
6871:
6867:
6863:
6859:
6855:
6851:
6847:
6843:
6838:
6834:
6830:
6826:
6822:
6817:
6812:
6808:
6804:
6800:
6795:
6791:
6787:
6783:
6779:
6774:
6769:
6765:
6761:
6758:(8): 869–81.
6757:
6753:
6749:
6744:
6740:
6736:
6731:
6726:
6722:
6718:
6714:
6710:
6706:
6701:
6697:
6693:
6689:
6685:
6681:
6677:
6672:
6668:
6664:
6659:
6654:
6650:
6646:
6643:(3): 147–59.
6642:
6638:
6634:
6629:
6625:
6621:
6617:
6613:
6609:
6605:
6601:
6597:
6592:
6588:
6584:
6580:
6576:
6572:
6568:
6563:
6559:
6555:
6551:
6547:
6543:
6539:
6535:
6531:
6528:(1): 258–65.
6527:
6523:
6518:
6514:
6510:
6506:
6502:
6497:
6492:
6488:
6484:
6480:
6475:
6471:
6467:
6463:
6459:
6455:
6451:
6446:
6442:
6438:
6434:
6430:
6427:(6): 473–81.
6426:
6422:
6417:
6413:
6409:
6405:
6401:
6397:
6393:
6389:
6385:
6379:
6378:
6373:
6365:
6361:
6356:
6351:
6347:
6343:
6339:
6335:
6331:
6324:
6321:
6316:
6312:
6307:
6302:
6298:
6294:
6290:
6283:
6280:
6275:
6271:
6267:
6263:
6259:
6258:10.1038/39522
6255:
6251:
6247:
6243:
6239:
6231:
6228:
6223:
6219:
6215:
6211:
6207:
6203:
6196:
6193:
6188:
6184:
6180:
6176:
6171:
6166:
6162:
6158:
6154:
6147:
6144:
6139:
6135:
6130:
6125:
6121:
6117:
6113:
6109:
6105:
6098:
6095:
6090:
6086:
6081:
6076:
6072:
6068:
6064:
6057:
6054:
6049:
6045:
6040:
6035:
6031:
6027:
6023:
6016:
6013:
6008:
6004:
6000:
5996:
5991:
5986:
5982:
5978:
5977:FASEB Journal
5974:
5967:
5964:
5959:
5955:
5950:
5945:
5941:
5937:
5933:
5926:
5923:
5918:
5914:
5909:
5904:
5899:
5894:
5890:
5886:
5882:
5878:
5874:
5867:
5864:
5859:
5855:
5850:
5845:
5841:
5837:
5833:
5826:
5823:
5818:
5814:
5809:
5804:
5800:
5796:
5792:
5785:
5782:
5777:
5773:
5769:
5765:
5761:
5757:
5753:
5749:
5742:
5739:
5734:
5730:
5725:
5720:
5715:
5710:
5706:
5702:
5698:
5694:
5690:
5683:
5680:
5675:
5671:
5666:
5661:
5657:
5653:
5649:
5642:
5639:
5634:
5630:
5626:
5622:
5618:
5614:
5607:
5604:
5599:
5595:
5590:
5585:
5581:
5577:
5573:
5566:
5563:
5558:
5554:
5549:
5544:
5540:
5536:
5532:
5525:
5523:
5519:
5514:
5510:
5505:
5500:
5496:
5492:
5488:
5484:
5480:
5473:
5471:
5467:
5462:
5458:
5453:
5448:
5443:
5438:
5434:
5430:
5426:
5419:
5417:
5415:
5411:
5406:
5402:
5397:
5392:
5388:
5384:
5380:
5373:
5370:
5365:
5361:
5356:
5351:
5347:
5343:
5339:
5335:
5331:
5324:
5321:
5316:
5312:
5307:
5302:
5297:
5292:
5288:
5284:
5280:
5273:
5270:
5265:
5261:
5256:
5251:
5247:
5243:
5240:(5): 737–40.
5239:
5235:
5231:
5224:
5221:
5216:
5212:
5207:
5202:
5197:
5192:
5188:
5184:
5180:
5173:
5170:
5165:
5161:
5157:
5153:
5149:
5145:
5137:
5134:
5129:
5125:
5120:
5115:
5111:
5107:
5104:(7): 809–15.
5103:
5099:
5095:
5088:
5085:
5080:
5076:
5071:
5066:
5061:
5056:
5052:
5048:
5045:(8): e72177.
5044:
5040:
5036:
5029:
5026:
5021:
5017:
5012:
5007:
5002:
4997:
4993:
4989:
4986:(8): e40287.
4985:
4981:
4977:
4970:
4967:
4962:
4958:
4953:
4948:
4944:
4940:
4936:
4932:
4928:
4921:
4918:
4913:
4909:
4904:
4899:
4895:
4891:
4887:
4883:
4880:(5): 055005.
4879:
4875:
4871:
4864:
4861:
4856:
4852:
4847:
4842:
4837:
4832:
4828:
4824:
4820:
4816:
4812:
4805:
4802:
4797:
4793:
4788:
4783:
4779:
4775:
4771:
4767:
4763:
4759:
4755:
4748:
4746:
4742:
4737:
4733:
4728:
4723:
4719:
4715:
4712:(8): 773–83.
4711:
4707:
4703:
4696:
4693:
4688:
4684:
4680:
4676:
4672:
4668:
4664:
4660:
4653:
4650:
4645:
4641:
4637:
4633:
4629:
4625:
4621:
4617:
4613:
4606:
4603:
4598:
4594:
4590:
4586:
4583:(1): 565–97.
4582:
4578:
4571:
4568:
4563:
4559:
4555:
4551:
4546:
4541:
4537:
4533:
4529:
4525:
4521:
4514:
4511:
4506:
4502:
4497:
4492:
4487:
4482:
4478:
4474:
4470:
4463:
4460:
4455:
4451:
4446:
4441:
4437:
4433:
4430:(1): 113–23.
4429:
4425:
4421:
4414:
4411:
4406:
4402:
4398:
4394:
4390:
4386:
4382:
4378:
4370:
4367:
4362:
4358:
4354:
4350:
4346:
4342:
4335:
4332:
4326:
4321:
4317:
4313:
4309:
4305:
4301:
4294:
4292:
4288:
4283:
4277:
4271:
4264:
4260:
4256:
4252:
4249:(1): 148–61.
4248:
4244:
4236:
4233:
4228:
4221:
4217:
4213:
4209:
4205:
4201:
4198:(4): 327–31.
4197:
4193:
4185:
4182:
4177:
4173:
4168:
4163:
4159:
4155:
4151:
4147:
4143:
4136:
4133:
4128:
4121:
4117:
4112:
4107:
4102:
4097:
4093:
4089:
4085:
4081:
4077:
4070:
4068:
4064:
4059:
4055:
4050:
4045:
4042:(3): 343–53.
4041:
4037:
4033:
4026:
4022:
4016:
4014:
4010:
4005:
4001:
3997:
3993:
3989:
3985:
3981:
3977:
3973:
3969:
3965:
3957:
3954:
3949:
3945:
3941:
3937:
3933:
3929:
3925:
3921:
3917:
3913:
3905:
3902:
3897:
3893:
3888:
3883:
3878:
3873:
3869:
3865:
3861:
3854:
3851:
3846:
3842:
3838:
3834:
3830:
3826:
3822:
3818:
3814:
3810:
3806:
3799:
3796:
3791:
3787:
3783:
3779:
3775:
3771:
3767:
3763:
3756:
3753:
3748:
3744:
3740:
3736:
3732:
3728:
3724:
3720:
3716:
3712:
3704:
3701:
3696:
3692:
3687:
3682:
3677:
3672:
3668:
3664:
3660:
3653:
3651:
3649:
3647:
3643:
3638:
3634:
3629:
3624:
3620:
3616:
3612:
3608:
3604:
3600:
3596:
3592:
3586:
3583:
3578:
3574:
3570:
3566:
3562:
3558:
3554:
3550:
3543:
3540:
3535:
3531:
3527:
3523:
3519:
3515:
3511:
3507:
3499:
3496:
3491:
3487:
3483:
3479:
3476:(2): 257–63.
3475:
3471:
3464:
3461:
3456:
3452:
3447:
3442:
3437:
3432:
3428:
3424:
3420:
3413:
3410:
3405:
3401:
3396:
3391:
3386:
3381:
3377:
3373:
3369:
3365:
3361:
3354:
3351:
3346:
3342:
3337:
3332:
3328:
3324:
3321:(6): 857–67.
3320:
3316:
3312:
3304:
3302:
3298:
3293:
3289:
3284:
3279:
3275:
3271:
3267:
3260:
3257:
3252:
3248:
3244:
3240:
3236:
3232:
3228:
3224:
3217:
3214:
3209:
3205:
3200:
3195:
3190:
3185:
3181:
3177:
3173:
3166:
3164:
3160:
3148:
3142:
3139:
3134:
3130:
3124:
3121:
3116:
3112:
3106:
3103:
3099:
3095:
3090:
3088:
3086:
3082:
3078:
3074:
3069:
3067:
3065:
3061:
3055:
3053:
3051:
3042:
3039:
3036:
3033:
3030:
3027:
3024:
3021:
3018:
3015:
3012:
3009:
3006:
3003:
3001:
2998:
2995:
2992:
2989:
2986:
2983:
2980:
2977:
2974:
2971:
2968:
2965:
2962:
2959:
2956:
2955:
2953:
2951:
2943:
2941:
2939:
2935:
2931:
2927:
2922:
2919:AβPP and its
2917:
2915:
2911:
2907:
2903:
2902:proliferation
2899:
2895:
2887:
2885:
2883:
2877:
2873:
2871:
2867:
2863:
2859:
2855:
2851:
2850:ceruloplasmin
2847:
2839:
2837:
2835:
2831:
2827:
2822:
2820:
2816:
2808:
2806:
2804:
2801:show greater
2800:
2796:
2792:
2788:
2780:
2778:
2774:
2771:
2767:
2766:knockout mice
2762:
2760:
2756:
2752:
2751:cell adhesion
2748:
2744:
2740:
2736:
2732:
2724:
2722:
2720:
2712:
2710:
2708:
2705:
2701:
2697:
2692:
2690:
2685:
2681:
2677:
2673:
2669:
2665:
2661:
2657:
2653:
2649:
2645:
2641:
2640:glycosylation
2637:
2629:
2624:
2620:
2615:
2611:
2604:
2602:
2600:
2597:(GFLD) and a
2596:
2591:
2583:
2582:proteoglycans
2580:
2576:
2572:
2571:
2566:
2561:
2554:
2550:
2546:
2542:
2537:
2530:
2528:
2524:
2520:
2518:
2514:
2510:
2509:
2504:
2503:
2498:
2493:
2489:
2486:spanning 290
2485:
2481:
2480:chromosome 21
2477:
2474:
2470:
2466:
2458:
2456:
2454:
2450:
2446:
2442:
2438:
2434:
2430:
2426:
2422:
2418:
2414:
2410:
2406:
2402:
2398:
2394:
2390:
2386:
2382:
2374:
2362:
2357:
2353:
2349:
2346:
2342:
2335:
2333:
2330:
2326:
2322:
2318:
2315:
2311:
2307:
2300:
2298:
2294:
2290:
2286:
2282:
2276:
2272:
2269:
2263:
2261:
2257:
2253:
2249:
2245:
2239:
2235:
2231:
2227:
2223:
2219:
2215:
2212:
2208:
2201:
2199:
2195:
2191:
2187:
2183:
2177:
2173:
2170:
2164:
2162:
2158:
2154:
2150:
2146:
2142:
2136:
2132:
2128:
2124:
2120:
2116:
2112:
2109:
2107:RefSeq (mRNA)
2105:
2098:
2097:
2092:
2088:
2085:
2079:
2078:
2073:
2069:
2066:
2064:
2060:
2053:
2052:
2047:
2043:
2040:
2034:
2033:
2028:
2024:
2021:
2019:
2015:
2008:
2007:
2002:
1998:
1995:
1989:
1988:
1983:
1979:
1976:
1974:
1970:
1967:
1964:
1962:
1959:
1955:
1952:
1948:
1944:
1937:
1933:
1928:
1922:
1919:
1917:
1914:
1912:
1909:
1907:
1904:
1902:
1899:
1897:
1894:
1892:
1889:
1887:
1884:
1882:
1879:
1877:
1874:
1872:
1869:
1867:
1864:
1862:
1859:
1857:
1854:
1852:
1849:
1847:
1844:
1842:
1839:
1837:
1834:
1832:
1829:
1827:
1824:
1822:
1819:
1817:
1814:
1812:
1809:
1807:
1804:
1802:
1799:
1797:
1794:
1792:
1789:
1787:
1784:
1782:
1779:
1777:
1774:
1772:
1769:
1767:
1764:
1762:
1759:
1757:
1754:
1752:
1749:
1747:
1744:
1742:
1739:
1737:
1734:
1732:
1729:
1727:
1724:
1722:
1719:
1717:
1714:
1712:
1709:
1707:
1704:
1702:
1699:
1697:
1694:
1692:
1689:
1687:
1684:
1682:
1679:
1677:
1674:
1672:
1669:
1667:
1664:
1662:
1659:
1657:
1654:
1652:
1649:
1647:
1644:
1642:
1639:
1637:
1634:
1632:
1629:
1627:
1624:
1622:
1619:
1617:
1614:
1612:
1609:
1607:
1604:
1602:
1599:
1597:
1594:
1592:
1589:
1587:
1584:
1582:
1579:
1577:
1574:
1572:
1571:cell adhesion
1569:
1567:
1564:
1562:
1559:
1557:
1554:
1552:
1549:
1547:
1544:
1542:
1539:
1537:
1534:
1532:
1529:
1527:
1524:
1522:
1519:
1517:
1514:
1512:
1509:
1507:
1504:
1502:
1499:
1497:
1494:
1492:
1489:
1487:
1484:
1482:
1479:
1477:
1474:
1472:
1469:
1467:
1464:
1462:
1459:
1457:
1454:
1452:
1449:
1447:
1444:
1442:
1439:
1437:
1434:
1432:
1429:
1427:
1424:
1422:
1419:
1418:
1416:
1413:
1412:
1406:
1403:
1401:
1398:
1396:
1393:
1391:
1388:
1386:
1383:
1381:
1378:
1376:
1373:
1371:
1368:
1366:
1363:
1361:
1358:
1356:
1353:
1351:
1348:
1346:
1343:
1341:
1338:
1336:
1333:
1331:
1328:
1326:
1323:
1321:
1318:
1316:
1313:
1311:
1308:
1306:
1303:
1301:
1298:
1296:
1293:
1291:
1288:
1286:
1283:
1281:
1278:
1276:
1273:
1271:
1268:
1266:
1263:
1261:
1258:
1256:
1253:
1251:
1248:
1246:
1245:membrane raft
1243:
1241:
1238:
1236:
1233:
1231:
1228:
1226:
1223:
1221:
1218:
1216:
1213:
1211:
1208:
1206:
1203:
1201:
1198:
1196:
1193:
1191:
1188:
1186:
1183:
1181:
1178:
1176:
1173:
1171:
1168:
1166:
1163:
1161:
1158:
1157:
1155:
1152:
1151:
1145:
1142:
1140:
1137:
1135:
1132:
1130:
1127:
1125:
1122:
1120:
1117:
1115:
1112:
1110:
1107:
1105:
1102:
1100:
1097:
1095:
1092:
1090:
1087:
1085:
1082:
1080:
1077:
1075:
1072:
1071:
1069:
1066:
1065:
1062:
1061:Gene ontology
1058:
1054:
1042:
1037:
1033:
1026:
1019:
1014:
1011:
1009:
1005:
997:
992:
981:
977:
973:
969:
965:
961:
957:
953:
949:
945:
944:
941:
937:
932:
929:
919:
915:
911:
907:
903:
899:
895:
892:renal medulla
891:
887:
883:
882:
879:
875:
870:
867:
866:
863:
861:
857:
855:
854:
850:
849:
846:
844:
840:
836:
832:
828:
820:
815:
811:
807:
802:
792:
788:
781:
774:
768:
761:
753:
749:
745:
740:
736:
731:
727:
719:
714:
710:
706:
701:
691:
687:
680:
673:
667:
660:
656:
650:
646:
642:
637:
633:
628:
624:
620:
616:
612:
608:
604:
600:
596:
592:
588:
584:
576:
571:
564:
559:
554:
543:
541:
537:
533:
529:
525:
521:
517:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
473:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
429:
425:
421:
417:
413:
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
365:
361:
357:
353:
349:
345:
341:
337:
333:
329:
325:
321:
317:
313:
309:
305:
301:
297:
293:
289:
285:
281:
277:
273:
269:
265:
261:
257:
253:
249:
245:
241:
237:
233:
229:
225:
221:
217:
213:
209:
205:
201:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
79:
74:
71:
70:
66:
63:
56:
52:
47:
43:
39:
34:
29:
26:
22:
7577:
7562:
7547:
7532:
7517:
7502:
7487:
7472:
7457:
7442:
7427:
7412:
7397:
7382:
7367:
7352:
7337:
7322:
7307:
7292:
7277:
7262:
7247:
7232:
7173:
7167:
7104:
7101:EMBO Reports
7100:
7061:
7057:
7028:
7022:
6990:(4): 430–7.
6987:
6983:
6946:
6942:
6907:
6903:
6882:
6878:
6845:
6841:
6816:10.2741/1911
6806:
6802:
6755:
6751:
6712:
6708:
6682:(6): 513–9.
6679:
6675:
6640:
6636:
6602:(2): 151–9.
6599:
6595:
6570:
6566:
6525:
6521:
6486:
6482:
6456:(1): 25–51.
6453:
6449:
6424:
6420:
6387:
6383:
6337:
6333:
6323:
6296:
6292:
6282:
6241:
6237:
6230:
6208:(2): 241–6.
6205:
6201:
6195:
6160:
6156:
6146:
6111:
6107:
6097:
6070:
6066:
6056:
6029:
6025:
6015:
5980:
5976:
5966:
5939:
5935:
5925:
5880:
5876:
5866:
5839:
5835:
5825:
5798:
5794:
5784:
5754:(3): 143–6.
5751:
5747:
5741:
5696:
5692:
5682:
5655:
5651:
5641:
5619:(3): 663–7.
5616:
5612:
5606:
5579:
5575:
5565:
5538:
5534:
5486:
5482:
5432:
5428:
5386:
5382:
5372:
5337:
5333:
5323:
5286:
5282:
5272:
5237:
5233:
5223:
5186:
5182:
5172:
5150:(3): 522–7.
5147:
5143:
5136:
5101:
5098:EMBO Reports
5097:
5087:
5042:
5038:
5028:
4983:
4979:
4969:
4934:
4930:
4920:
4877:
4873:
4863:
4818:
4814:
4804:
4761:
4757:
4709:
4705:
4695:
4662:
4658:
4652:
4619:
4616:Neuroscience
4615:
4605:
4580:
4576:
4570:
4527:
4523:
4513:
4476:
4472:
4462:
4427:
4423:
4413:
4380:
4376:
4369:
4344:
4340:
4334:
4307:
4303:
4246:
4242:
4235:
4204:10.1038/7562
4195:
4191:
4184:
4149:
4145:
4135:
4083:
4079:
4039:
4035:
3971:
3967:
3956:
3915:
3911:
3904:
3867:
3863:
3853:
3812:
3808:
3798:
3765:
3761:
3755:
3714:
3710:
3703:
3666:
3662:
3602:
3598:
3585:
3552:
3548:
3542:
3512:(1): 22–30.
3509:
3505:
3498:
3473:
3469:
3463:
3426:
3423:BMC Genomics
3422:
3412:
3367:
3363:
3353:
3318:
3314:
3273:
3269:
3259:
3226:
3222:
3216:
3179:
3175:
3150:. Retrieved
3141:
3132:
3123:
3114:
3105:
3047:
2947:
2944:Interactions
2918:
2914:progesterone
2891:
2878:
2874:
2843:
2823:
2812:
2802:
2784:
2775:
2763:
2728:
2716:
2693:
2633:
2608:
2587:
2568:
2525:
2521:
2517:native-state
2506:
2500:
2475:
2462:
2433:amyloid beta
2420:
2384:
2380:
2379:
2293:NP_001185755
2289:NP_001185754
2285:NP_001185753
2281:NP_001185752
2278:
2252:NP_001191232
2248:NP_001191231
2244:NP_001191230
2241:
2234:NP_001129603
2230:NP_001129602
2226:NP_001129601
2222:NP_001129488
2194:NM_001198826
2190:NM_001198825
2186:NM_001198824
2182:NM_001198823
2179:
2161:NM_001385253
2153:NM_001204303
2149:NM_001204302
2145:NM_001204301
2141:NM_001136131
2138:
2131:NM_001136130
2127:NM_001136129
2123:NM_001136016
2094:
2075:
2049:
2030:
2004:
1985:
1965:
1960:
1606:axonogenesis
1235:cell surface
946:ciliary body
858:
851:
578:External IDs
81:
25:
7924:Amyloidosis
7622:Amyloidosis
7215:PDB gallery
6885:(1): 44–7.
6879:Pathologica
6773:11336/43663
6748:Connolly ES
4659:NeuroReport
3229:(1): 1–32.
2936:and during
2858:ferroportin
2854:iron export
2846:ferroxidase
2840:Iron export
2735:upregulated
2700:cholesterol
2696:lipid rafts
2656:proteolytic
2648:sialylation
2565:coiled coil
2547:of the two
2545:side chains
2437:polypeptide
2429:proteolysis
2417:iron export
1601:endocytosis
1355:Golgi lumen
1265:growth cone
1114:DNA binding
817:84,970,654
804:84,746,573
716:26,171,128
703:25,880,550
556:Identifiers
7898:Categories
3555:: 116–23.
3429:(1): 290.
3152:10 January
3100:, May 2017
3079:, May 2017
3056:References
2938:andropause
2926:cell cycle
2882:hephaestin
2770:phenotypic
2731:expression
2689:presenilin
2638:including
2621:cells and
2570:Drosophila
2508:C. elegans
2502:Drosophila
2497:Homologous
2490:. Several
2455:patients.
2441:amino acid
2431:generates
1385:perikaryon
912:C1 segment
862:(ortholog)
599:HomoloGene
7857:Pituitary
7837:Endocrine
6842:Neurology
5289:(4): 28.
4279:,
4273:,
4028:;
3870:(1): 31.
3619:0014-4819
2934:menopause
2680:apoptosis
2664:secretase
2660:proteases
2549:histidine
2543:ion. The
2531:Structure
2488:kilobases
2297:NP_031497
2260:NP_958817
2256:NP_958816
2218:NP_000475
2198:NM_007471
2157:NM_201413
2119:NM_000484
2115:NM_201414
1951:Orthologs
1806:cognition
1325:main axon
1160:cytoplasm
950:CA3 field
607:GeneCards
7869:Pancreas
7131:17268504
7088:17215111
7045:17168650
7014:17113271
6971:45002038
6963:16909010
6934:20879380
6926:16893414
6891:16789686
6870:35965729
6862:16432149
6833:26325962
6825:16368544
6790:25687818
6782:16354549
6739:16252002
6696:16101387
6667:15910549
6624:31985212
6616:15672415
6587:12824062
6558:22567664
6550:12480759
6513:40411806
6505:12383342
6470:12142279
6441:12069633
6412:22058428
6364:19515914
6315:11877420
6222:10329371
6187:83321033
6179:11238726
6138:11927537
6048:15037614
6007:44302063
5999:10973933
5958:12529377
5776:54307954
5768:10081969
5633:10049767
5557:12972431
5461:12196555
5405:14871891
5364:12890786
5315:20836886
5264:18803462
5215:19542221
5164:17959150
5128:24867889
5079:23977245
5039:PLOS ONE
5020:22916096
4980:PLOS ONE
4961:19021541
4912:23011729
4855:17062754
4796:30464338
4736:18648325
4687:34157306
4679:17558301
4636:10338291
4612:Jucker M
4597:12730322
4562:15502857
4554:11525745
4505:15322084
4454:12515826
4397:16641999
4361:10806097
4325:11130256
4285:.
4263:17239395
4220:30925432
4212:10201399
4120:20212142
4058:15304215
3996:22801501
3896:32164763
3805:Rossor M
3695:16930452
3669:(1): 5.
3637:22038715
3591:Ewald CY
3577:26901380
3569:17586478
3534:42752531
3455:23627794
3404:34385305
3345:20817278
3292:30314800
3251:25376584
3243:12927332
3208:16822978
3096:–
3075:–
3035:HSD17B10
2950:interact
2921:cleavage
2757:protein
2755:receptor
2707:genotype
2666:family;
2575:spectrin
2553:tyrosine
2551:and one
2459:Genetics
2435:(Aβ), a
2397:synapses
2387:) is an
2345:Wikidata
1930:Sources:
1716:learning
1180:membrane
1165:endosome
7845:Thyroid
7631:amyloid
7629:Common
7122:1796780
7079:1876750
7005:1862818
6730:1356301
6658:2517409
6530:Bibcode
6483:Traffic
6404:8239320
6355:2759694
6274:4343238
6266:9338779
6246:Bibcode
6089:9553108
5917:9843960
5885:Bibcode
5858:8626687
5817:9837937
5733:8855266
5701:Bibcode
5674:9045663
5598:9890987
5513:8887653
5452:6757996
5355:6740729
5306:2983441
5255:2891507
5206:2749153
5119:4196985
5070:3747053
5047:Bibcode
5011:3419245
4988:Bibcode
4952:2746665
4903:3625656
4882:Bibcode
4846:1621108
4823:Bibcode
4787:6391999
4766:Bibcode
4727:3334532
4644:6001957
4532:Bibcode
4496:1201506
4445:2172747
4405:4349251
4230:
4176:8331390
4167:6576678
4130:
4111:2851805
4088:Bibcode
4004:4333449
3976:Bibcode
3948:4341170
3940:1465129
3920:Bibcode
3887:7068954
3845:4345311
3837:1944558
3817:Bibcode
3790:1925564
3770:Bibcode
3762:Science
3747:4336069
3739:1671712
3719:Bibcode
3686:1538601
3628:3746071
3526:8220418
3490:2110105
3446:3660159
3395:8379952
3372:Bibcode
3336:2943017
3199:6673945
3098:Ensembl
3077:Ensembl
3017:COL25A1
2900:(hESC)
2868:of APP
2864:in the
2830:glycine
2819:kinesin
2795:Neurons
2662:in the
2623:SH-SY5Y
2619:SH-SY5Y
2590:domains
2513:mammals
2401:neurons
2393:tissues
2063:UniProt
2018:Ensembl
1957:Species
1936:QuickGO
1400:nucleus
1190:synapse
1170:cytosol
837:pattern
695:21q21.3
563:Aliases
7796:Kidney
7165:Human
7157:(MeSH)
7129:
7119:
7086:
7076:
7043:
7012:
7002:
6969:
6961:
6932:
6924:
6889:
6868:
6860:
6831:
6823:
6788:
6780:
6737:
6727:
6694:
6665:
6655:
6622:
6614:
6585:
6556:
6548:
6511:
6503:
6468:
6439:
6410:
6402:
6362:
6352:
6313:
6272:
6264:
6238:Nature
6220:
6185:
6177:
6136:
6129:125364
6126:
6087:
6046:
6005:
5997:
5956:
5915:
5905:
5856:
5815:
5774:
5766:
5731:
5721:
5672:
5631:
5596:
5555:
5511:
5504:231626
5501:
5459:
5449:
5403:
5362:
5352:
5313:
5303:
5262:
5252:
5213:
5203:
5162:
5126:
5116:
5077:
5067:
5018:
5008:
4959:
4949:
4910:
4900:
4853:
4843:
4794:
4784:
4758:Nature
4734:
4724:
4685:
4677:
4642:
4634:
4595:
4560:
4552:
4503:
4493:
4452:
4442:
4403:
4395:
4377:Nature
4359:
4322:
4261:
4218:
4210:
4174:
4164:
4118:
4108:
4056:
4002:
3994:
3968:Nature
3946:
3938:
3912:Nature
3894:
3884:
3843:
3835:
3809:Nature
3788:
3745:
3737:
3711:Nature
3693:
3683:
3635:
3625:
3617:
3575:
3567:
3532:
3524:
3488:
3453:
3443:
3402:
3392:
3343:
3333:
3290:
3249:
3241:
3206:
3196:
3050:reelin
3005:CLSTN1
2994:BCAP31
2988:APPBP2
2982:APPBP1
2952:with:
2749:, and
2650:, and
2599:copper
2541:copper
2471:, the
2469:humans
2467:. In
2331:search
2329:PubMed
2096:P12023
2077:P05067
1973:Entrez
1008:BioGPS
587:104760
7768:Brain
7754:Heart
7669:AIAPP
6967:S2CID
6930:S2CID
6866:S2CID
6829:S2CID
6786:S2CID
6620:S2CID
6554:S2CID
6509:S2CID
6408:S2CID
6270:S2CID
6183:S2CID
6003:S2CID
5908:24520
5772:S2CID
5724:38241
4683:S2CID
4640:S2CID
4558:S2CID
4401:S2CID
4310:(1).
4216:S2CID
4000:S2CID
3944:S2CID
3841:S2CID
3743:S2CID
3573:S2CID
3530:S2CID
3247:S2CID
3037:, and
3023:FBLN1
2976:APBB1
2970:APBA3
2964:APBA2
2958:APBA1
2866:5'UTR
2826:beads
2787:brain
2759:Notch
2484:exons
2006:11820
1966:Mouse
1961:Human
1932:Amigo
860:Mouse
853:Human
800:Start
735:Mouse
699:Start
632:Human
603:56379
595:88059
7814:Skin
7694:ABri
7689:ACys
7684:AANF
7679:APro
7674:ACal
7650:Aβ2M
7645:ATTR
7578:2g47
7563:2fma
7548:2fkl
7533:2fk3
7518:2fk2
7503:2fk1
7488:2fjz
7473:2beg
7458:1zjd
7443:1z0q
7428:1tkn
7413:1taw
7398:1rw6
7383:1owt
7368:1mwp
7353:1iyt
7338:1ca0
7323:1brc
7308:1ba6
7293:1ba4
7278:1aml
7263:1amc
7248:1amb
7233:1aap
7127:PMID
7084:PMID
7062:1772
7041:PMID
7010:PMID
6988:1772
6959:PMID
6922:PMID
6887:PMID
6858:PMID
6821:PMID
6778:PMID
6735:PMID
6692:PMID
6663:PMID
6612:PMID
6583:PMID
6546:PMID
6501:PMID
6466:PMID
6437:PMID
6400:PMID
6360:PMID
6311:PMID
6262:PMID
6218:PMID
6175:PMID
6134:PMID
6085:PMID
6044:PMID
5995:PMID
5954:PMID
5913:PMID
5854:PMID
5813:PMID
5764:PMID
5729:PMID
5670:PMID
5629:PMID
5594:PMID
5553:PMID
5509:PMID
5457:PMID
5401:PMID
5360:PMID
5311:PMID
5260:PMID
5211:PMID
5160:PMID
5124:PMID
5075:PMID
5016:PMID
4957:PMID
4908:PMID
4851:PMID
4792:PMID
4732:PMID
4675:PMID
4632:PMID
4593:PMID
4550:PMID
4501:PMID
4450:PMID
4393:PMID
4357:PMID
4282:2FKL
4276:2FK2
4270:2FJZ
4259:PMID
4227:1MWP
4208:PMID
4172:PMID
4127:3KTM
4116:PMID
4054:PMID
4025:1RW6
3992:PMID
3936:PMID
3892:PMID
3833:PMID
3786:PMID
3735:PMID
3691:PMID
3633:PMID
3615:ISSN
3565:PMID
3553:1161
3522:PMID
3486:PMID
3470:Gene
3451:PMID
3400:PMID
3341:PMID
3315:Cell
3288:PMID
3239:PMID
3204:PMID
3154:2021
3041:SHC1
3011:CAV1
3000:BLMH
2870:mRNA
2834:COOH
2764:APP
2670:and
2473:gene
1300:axon
966:iris
843:Bgee
791:Band
752:Chr.
690:Band
649:Chr.
583:OMIM
540:2NAO
536:5C67
532:5KK3
528:5HOX
524:5HOW
520:5HOY
516:5BUO
512:5AM8
508:5AEF
504:5AMB
500:5CSZ
496:4XXD
492:4MVL
488:4MVK
484:4MVI
480:4PWQ
476:4PQD
472:4ONG
468:4ONF
464:4OJF
460:4NGE
456:4MDR
452:4M1C
448:4JFN
444:3OW9
440:3OVJ
436:3NYJ
432:3MXC
428:3JQL
424:3JQ5
420:3BKJ
416:3BAE
412:2MXU
408:2MVX
404:2MPZ
400:2MJ1
396:2MGT
392:2M9S
388:2M9R
384:2M4J
380:2LZ4
376:2LZ3
372:2LNQ
368:1ZE9
364:1ZE7
360:4HIX
356:3UMK
352:3UMI
348:3UMH
344:3U0T
340:3SV1
336:3NYL
332:3MOQ
328:3L81
324:3L33
320:3KTM
316:3JTI
312:3IFP
308:3IFO
304:3IFN
300:3IFL
296:3GCI
292:3DXE
288:3DXD
284:3DXC
280:3AYU
276:2Y3L
272:2Y3K
268:2Y3J
264:2Y2A
260:2Y29
256:2WK3
252:2R0W
248:2OTK
244:2LP1
240:2LOH
236:2LMQ
232:2LMP
228:2LMO
224:2LMN
220:2LLM
216:2LFM
212:2IPU
208:2G47
204:2FMA
200:2FKL
196:2FK3
192:2FK2
188:2FK1
184:2FJZ
180:2BP4
176:2BEG
172:1ZJD
168:1Z0Q
164:1X11
160:1TKN
156:1TAW
152:1QYT
148:1QXC
144:1QWP
140:1QCM
136:1OWT
132:1MWP
128:1IYT
124:1HZ3
120:1CA0
116:1BRC
112:1BJC
108:1BJB
104:1BA6
100:1BA4
96:1AML
92:1AMC
88:1AMB
84:1AAP
65:RCSB
62:PDBe
7664:APP
7174:APP
7168:APP
7117:PMC
7109:doi
7074:PMC
7066:doi
7033:doi
7000:PMC
6992:doi
6951:doi
6912:doi
6850:doi
6811:doi
6768:hdl
6760:doi
6725:PMC
6717:doi
6684:doi
6653:PMC
6645:doi
6604:doi
6575:doi
6538:doi
6526:977
6491:doi
6458:doi
6429:doi
6392:doi
6388:695
6350:PMC
6342:doi
6301:doi
6297:277
6254:doi
6242:389
6210:doi
6206:258
6165:doi
6124:PMC
6116:doi
6075:doi
6071:273
6034:doi
6030:279
5985:doi
5944:doi
5940:278
5903:PMC
5893:doi
5844:doi
5840:271
5803:doi
5799:273
5756:doi
5752:261
5719:PMC
5709:doi
5660:doi
5656:272
5621:doi
5617:255
5584:doi
5580:274
5543:doi
5539:278
5499:PMC
5491:doi
5447:PMC
5437:doi
5391:doi
5387:279
5350:PMC
5342:doi
5301:PMC
5291:doi
5250:PMC
5242:doi
5201:PMC
5191:doi
5187:284
5152:doi
5148:364
5114:PMC
5106:doi
5065:PMC
5055:doi
5006:PMC
4996:doi
4947:PMC
4939:doi
4898:PMC
4890:doi
4841:PMC
4831:doi
4819:103
4782:PMC
4774:doi
4762:563
4722:PMC
4714:doi
4667:doi
4624:doi
4585:doi
4540:doi
4491:PMC
4481:doi
4477:279
4440:PMC
4432:doi
4428:160
4385:doi
4381:440
4349:doi
4345:113
4320:PMC
4312:doi
4251:doi
4247:367
4200:doi
4162:PMC
4154:doi
4106:PMC
4096:doi
4084:107
4044:doi
4021:PDB
3984:doi
3972:488
3928:doi
3916:360
3882:PMC
3872:doi
3825:doi
3813:353
3778:doi
3766:254
3727:doi
3715:349
3681:PMC
3671:doi
3623:PMC
3607:doi
3603:217
3557:doi
3514:doi
3478:doi
3441:PMC
3431:doi
3390:PMC
3380:doi
3368:118
3331:PMC
3323:doi
3319:142
3278:doi
3231:doi
3194:PMC
3184:doi
3029:GSN
2884:).
2803:APP
2733:is
2476:APP
2421:APP
2399:of
2385:APP
1987:351
813:End
712:End
615:OMA
611:APP
591:MGI
570:APP
55:PDB
31:APP
7900::
7660:Aβ
7655:AL
7640:AA
7125:.
7115:.
7103:.
7099:.
7082:.
7072:.
7060:.
7056:.
7039:.
7027:.
7008:.
6998:.
6986:.
6982:.
6965:.
6957:.
6945:.
6928:.
6920:.
6908:98
6906:.
6902:.
6883:98
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6864:.
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6846:66
6844:.
6827:.
6819:.
6807:11
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6801:.
6784:.
6776:.
6766:.
6756:27
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6733:.
6723:.
6713:24
6711:.
6707:.
6690:.
6680:12
6678:.
6661:.
6651:.
6641:86
6639:.
6635:.
6618:.
6610:.
6600:80
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6581:.
6571:35
6569:.
6552:.
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6536:.
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6481:.
6464:.
6454:18
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6024:.
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5981:14
5979:.
5975:.
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5938:.
5934:.
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