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599: Patricia Seoane-Collazo, Laura Liñares-Pose, Eva Rial-Pensado, Amparo Romero-Picó, José María Moreno-Navarrete, Noelia Martínez-Sánchez, Pablo Garrido-Gil, Ramón Iglesias-Rey, Donald A Morgan, Naoki Tomasini, Samuel Andrew Malone, Ana Senra, Cintia Folgueira, Gema Medina-Gomez, Tomás Sobrino, José L Labandeira-García, Rubén Nogueiras,
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Inês Mahú, Andreia
Barateiro, Eva Rial-Pensado, Noelia Martinéz-Sánchez, Sandra H Vaz, Pedro M S D Cal, Benjamin Jenkins, Tiago Rodrigues, Carlos Cordeiro, Miguel F Costa, Raquel Mendes, Elsa Seixas, Mafalda M A Pereira, Nadiya Kubasova, Vitka Gres, Imogen Morris, Carolina Temporão, Marta Olivares,
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in 2015. Following on from this discovery, the
Domingos laboratory, provided the first visualization of adipose sympathetic neurons and demonstrated its necessity for fat mass reduction via norepinephrine signaling. Therefore, the Domingos group in Portugal characterized the peripheral efferent arm
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Roksana M Pirzgalska, Elsa Seixas, Jason S Seidman, Verena M Link, Noelia Martínez Sánchez, Inês Mahú, Raquel Mendes, Vitka Gres, Nadiya
Kubasova, Imogen Morris, Bernardo A Arús, Chelsea M Larabee, Miguel Vasques, Francisco Tortosa, Ana L Sousa, Sathyavathy Anandan, Erin Tranfield, Maureen K Hahn,
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Haberman, Emma R.; Sarker, Gitalee; Arus, Bernardo A.; Yilmaz-Ozcan, Sinem; Martinez-Sanchez, Noelia; Freibergerova, Eliska; Fernandez-Gonzalez, Iara; Zentai, Chloe; O'Brien, Conan J. O.; Grainger, David E.; Chakarov, Svetoslav; Raimondi, Andrea; Iannacone, Matteo; Lopez, Miguel; Ginhoux, Florent
226:, thereby limiting side effects. These new and improved compounds are dubbed sympathofacilitators. To this end, the Domingos' group studies the circuit properties of sympathetic neural networks interact with fat and how they are regulated by immune cells, pioneering a new field of research coined
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to control fat breakdown. Sympathetic nerves release a hormone called noradrenaline which is received by a molecular switch expressed by fat tissue, called a β-2 receptor. Activation of the β-2 receptor or "switch" causes the fat tissue to "burn off" as heat. Secondly, her laboratory was able to
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Aylesse
Sordillo, Marcelo O Dietrich, Zhong-Wu Liu, Luis A Tellez, Jake Vaynshteyn, Jozelia G Ferreira, Mats I Ekstrand, Tamas L Horvath, Ivan E de Araujo, Jeffrey M Friedman. Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar. Elife. 2013 Dec
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Pirzgalska, Roksana M.; Seixas, Elsa; Seidman, Jason S.; Link, Verena M.; Sánchez, Noelia Martínez; Mahú, Inês; Mendes, Raquel; Gres, Vitka; Kubasova, Nadiya; Morris, Imogen; Arús, Bernardo A.; Larabee, Chelsea M.; Vasques, Miguel; Tortosa, Francisco; Sousa, Ana L. (November 2017).
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of the
University of Oxford as an Associate Professor in Neuroscience. In 2022, Domingos advanced to the position of (full) Professor of Neuroscience where she heads a laboratory bearing her name. Her laboratory in Oxford, in a collaborative effort with the
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Zeng, Wenwen; Pirzgalska, Roksana M.; Pereira, Mafalda M. A.; Kubasova, Nadiya; Barateiro, Andreia; Seixas, Elsa; Lu, Yi-Hsueh; Kozlova, Albina; Voss, Henning; Martins, Gabriel G.; Friedman, Jeffrey M.; Domingos, Ana I. (2015-09-24).
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in the neuroendocrine loop of afferent leptin action in the brain. In
Gulbenkian, Domingo's also discovered sympathetic neuron-associated macrophages (SAMs) contribute to obesity by importing and metabolizing norepinephrine.
694:, Jake Vaynshteyn, Henning U Voss, Xueying Ren, Viviana Gradinaru, Feng Zang, Karl Deisseroth, Ivan E de Araujo, Jeffrey Friedman. Leptin regulates the reward value of nutrient. Nature Neurosci. 2011 Nov 13;14(12):1562-8.
688:, Leah Kelly, Alastair Garfield, Shadi Damanpour, Lora Heisler, Jeffrey Friedman. Profiling of Glucose-Sensing Neurons Reveals that GHRH Neurons Are Activated by Hypoglycemia. Cell Metab. 2013 Oct 1;18(4):596-607.
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is a
Portuguese neuroscientist specialising in the treatment of obesity independently of food intake. Domingos is a full Professor of Neuroscience at the Department of Physiology, Anatomy and Genetics of the
681:, Jake Vaynshteyn, Aylesse Sordillo, Jeffrey M Friedman. The reward value of sucrose in leptin-deficient obese mice. Mol Metab. 2013 Dec 5;3(1):73-80. doi: 10.1016/j.molmet.2013.10.007. eCollection 2014 Feb.
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708:, Walton D Jones, M Eugenia Chiappe, Hubert Amrein, Leslie B Vosshall. Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction. Neuron. 2004 September 2;43(5):703-14.
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Haberman, Emma Rose, et al. "Immunomodulatory Leptin
Receptor Sympathetic Perineurial Cells Protect Against Obesity by Facilitating Neuroendocrine-Mediated Brown Adipose Tissue Thermogenesis." B
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Domingos has published widely in peer-reviewed journals. The
Domingos group is actively publishing, with two manuscripts under review as of May 2023. Domingos is the Editor-in-Chief of the
603:, José-Manuel Fernández-Real, Kamal Rahmouni, Carlos Diéguez, Miguel López. Central nicotine induces browning through hypothalamic κ opioid receptors. Nature Commun. 2019 Sep 6;10(1):4037.
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Wenwen Zeng, Roksana M Pirzgalska, Mafalda M A Pereira, Nadiya
Kubasova, Andreia Barateiro, Elsa Seixas, Yi-Hsueh Lu, Albina Kozlova, Henning Voss, Gabriel G Martins, Jeffrey M Friedman,
701:, Kenta Asahina, Félix Naef, Leslie B Vosshall, Matthieu Louis. Chemotaxis behavior mediated by single larval olfactory neurons in Drosophila. Current Biol. 2005 Dec 6;15(23):2086-96.
596:, Anna L Marsland, Vijay Kumar Yadav, Kamal Rahmouni, Xiao-Bing Gao, Gerard Karsenty. Mediation of the Acute Stress Response by the Skeleton. Cell Metab. 2019 Nov 5;30(5):890-902.e8
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Mafalda M A Pereira, Inês Mahú, Elsa Seixas, Noelia Martinéz-Sánchez, Nadiya Kubasova, Roksana M Pirzgalska, Paul Cohen, Marcelo O Dietrich, Miguel López, Gonçalo J L Bernardes,
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at the Rockefeller University. Domingos studied how metabolic signals affect neural circuitry underlying sweetener choices while in the Friedman lab, publishing several works.
639:, Richard Bonneau, Dan R Littman. An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses. Cell. 2016 January 14;164(1-2):324.
324:, has developed a new class of anti-obesity compounds that could potentially avoid the harmful side effects of traditional treatments. Domingos aims to shift the treatment
1224:"Immunomodulatory Leptin Receptor+ Sympathetic Perineurial Cells Protect Against Obesity by Facilitating Neuroendocrine-Mediated Brown Adipose Tissue Thermogenesis"
656: Bernardo S Reis, Kihyun Lee, Melania H Fanok, Cristina Mascaraque, Manal Amoury, Lillian B Cohn, Aneta Rogoz, Olof S Dallner, Pedro M Moraes-Vieira,
618:. Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine. Nature Medicine. 2017 Nov;23(11):1309-1318.
533:. The sympathetic nervous system in the 21st Century: neuro-immune interactions in metabolic homeostasis and obesity. Neuron 110(21), 3597-3626 (2022).
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Domingos also hold patents in the UK and US regarding pharmacological targeting of sympathetic associated macrophages to drive thermogenic activity
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562:. Brain-sparing sympathofacilitators mitigate obesity without adverse cardiovascular effects. Cell Metabolism June 2;31(6):1120-1135 (2020).
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Filipa Cardoso, Roel G J Klein Wolterink, Cristina Godinho-Silva, Rita G Domingues, Hélder Ribeiro, Joaquim Alves da Silva, Inês Mahú,
660:, Daniel Mucida. Leptin receptor signaling in T cells is required for Th17 differentiation. J Immunology. 2015 June 1;194(11):5253-60.
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218:, the Domingos' lab in Oxford hopes to improve upon sympathomimetics, by producing a class of compounds that do not interact with the
540:, Henrique Veiga-Fernandes. Neuro-mesenchymal units control ILC2 and Obesity via a brain–adipose circuit. Nature 597, 410–414 (2021).
156:, Domingos studied the sensory systems facilitating our sense of smell. As a post-doctoral research scientist, Domingos worked under
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Teruyuki Sano, Wendy Huang, Jason A Hall, Yi Yang, Alessandra Chen, Samuel J Gavzy, June-Yong Lee, Joshua W Ziel, Emily R Miraldi,
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in Portugal where she made a number of key discoveries. Firstly, her laboratory discovered that a hormone produced by fat, called
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625:. A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages. Nature Commun. 2017 Apr 3;8:14967.
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Julian Meyer Berger, Parminder Singh, Lori Khrimian, Donald A Morgan, Subrata Chowdhury, Emilio Arteaga-Solis, Tamas L Horvath,
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554:. A Tale of Three Systems: Toward a Neuroimmunoendocrine Model of Obesity. Annual Rev Cell Dev Biol. 2021 October 6;37:549-573.
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Domingos promotes science communication. Listed below are a number of freely available research talks and media appearances.
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610:. The structure of Orco and its impact on our understanding of olfaction.J Gen Physiol. 2018 Dec 3;150(12):1602-1605.
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Domingos discusses optogenetics to study the relationship between the immune system and sympathetic nervous system
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1100:"Pfizer Global Medical Grants Announces a New Research RFP in Obesity | The Association for the Study of Obesity"
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295:. While at Gulbenkian, the Domingos laboratory discovered that the sympathetic neuro-adipose axis mediates the
925:"Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine"
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O’Brien, Conan JO, and Ana I. Domingos. "Old and “hangry” monocytes turn from friend to foe under assault."
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Domingos leads a research laboratory consisting of three postdoctoral research scientists, four graduate (
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immune cells close to sympathetic neurons, dubbed sympathetic associated macrophages, could contribute to
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653:. Sympathetic neuro-adipose connections mediate leptin-driven lipolysis. Cell. 2015 Sep 24;163(1):84-94.
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632:. Leptin Resistance and the Neuro-Adipose Connection. Frontiers Endocrinol (Lausanne). 2017 Mar 6;8:45.
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Yolanda Sanz, Albert Koulman, Francisco Corzana, Ana M Sebastião, Miguel López, Gonçalo J L Bernardes,
160:, investigating how ones metabolism can influence the brain circuitry involved in sweetener cravings.
646:. Sweet and Low on Leptin: Hormonal Regulation of Sweet Taste Buds. Diabetes. 2015 Nov;64(11):3651-2.
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The following is a list of Domingos' groups most recent publications. To stay up to date, check out
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in the United Kingdom. Domingos is also a fellow, tutor and the director of studies in medicine at
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363:) students and a research assistant. Members of the Domingos laboratory have secured funding from
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A trained mathematician, Domingos began her research career by pursuing a Ph.D in neurobiology at
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Noelia Martinez-Sanchez, Owen Sweeney, Davi Sidarta-Oliveira, Alexandre Caron, Sarah A. Stanley,
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454:"Mouse brains eavesdrop on their fat" by Alejandra Manjarrez, The New Scientist ft. Ana Domingos
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A selection of her articles for which she has been the sole author or lead article follows.
589:. Leptin: a missing piece in the immunometabolism puzzle. Nature Rev Immunology. 20, 3 (2020)
583:. Obesity: a neuroimmunometabolic perspective. Nature Rev Endocrinol. Jan;16(1):30-43. (2020)
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As of 2023, the Domingos group is currently funded by competitive research grants from the
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Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar
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dubbed sympathofacilitators. Sympathofacilitators act as an energy sink by coupling
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1052:"Ana DOMINGOS Inventions, Patents and Patent Applications - Justia Patents Search"
576:. Illuminating Neuroimmunity: A Humoral Brain. Immunity 16;52(6):900-902 (2020).
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444:"Neuroimmunometabolism" by Ana Domingos at Oxford University Scientific Society
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AI Domingos, A Sordillo, MO Dietrich, ZW Liu, LA Tellez, J Vaynshteyn, et al.
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Leptin: a missing piece in the immunometabolism puzzle. Nature Rev Immunology
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449:"Optogenetics for neuroimmunity" by Ana Domingos at Society for Neuroscience
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2018: Marie Curie Postdoctoral Fellowship to fund project in Domingos group
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2020: Marie Curie Postdoctoral Fellowship to fund project in Domingos group
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Between 1995 and 1999, Domingos studied mathematics up to MSc level at the
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and in Paris. She then studied for a PhD in olfactory neuroscience at the
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1076:"Domingos Group — Department of Physiology, Anatomy and Genetics (DPAG)"
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815:"Sympathetic neuro-adipose connections mediate leptin-driven lipolysis"
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AI Domingos, J Vaynshteyn, HU Voss, X Ren, V Gradinaru, F Zang, et al.
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2023: American Physiological Society, Karl Ludwig Distinguished Lecture
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She then returned to Portugal to work at the Obesity Laboratory of the
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1124:"Cientistas descobrem que sistema imunitário contribui para obesidade"
547:. An anti-obesity immunotherapy?. Science Vol 373, 6550 24-25 (2021).
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Ana Domingos media appearance in "Food for Thought" article on eLife
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University of Lisbon, Portugal Rockefeller University, New York, USA
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476:. Domingos is also a member of the Advisory Board of the journal,
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667:. Cellular and molecular basis of decision-making. EMBO Rep. 2014
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to active heat dissipation. Sympathofacilitators improve upon
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439:"Neuroimmunometabolism" by Ana Domingos at Global Immunotalks
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303:. This discovery culminated in a seminal work, published in
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Between 2006 and 2013, Domingos did post-doctoral work with
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The reward value of sucrose in leptin-deficient obese mice
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Matteo Iannacone, Nathanael J Spann, Christopher K Glass,
569:. ILC3s gut rhythm. Nature Immunology. 21, 106–108 (2020).
1173:"Ana Domingos joins the Cell Metabolism Advisory Board"
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interacting with fat. Collaborating with scientists in
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Talk on Neuroimmunometabolism by Domingos (in English)
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Leptin: a missing piece in the immunometabolism puzzle
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of obesity, through the development of a new class of
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Department of Physiology, Anatomy and Genetics (DPAG)
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AI Domingos, J Vaynshteyn, A Sordillo, JM Friedman.
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459:"Food for Thought" Ana Domingos interview on eLife
414:2015: EMBO, Young Investigator Installation Award
398:. Notable previous prestigious awards include;
184:. Thirdly, the Domingos laboratory studied how
1177:Department of Physiology, Anatomy and Genetics
41:Ana Domingos headshot from DPAG staff listings
725:Leptin regulates the reward value of nutrient
210:behave like the chemical signals produced by
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163:Domingos founded her own laboratory in the
126:https://www.dpag.ox.ac.uk/research/domingos
123:https://www.dpag.ox.ac.uk/team/ana-domingos
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727:. Nature neuroscience 14 (12), 1562-1568
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748:. Nature Reviews Immunology 20 (1), 3-3
741:. Molecular metabolism 3 (1), 73-80 279
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411:2016: Human Frontiers Science Program
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474:Endocrinology and Metabolism Journal
579:Chelsea M Larabee, Oliver C Neely,
565:Gitalee Sarker, Chelsea M Larabee,
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642:Nadiya Kubasova, Denis Burdakov,
348:, thereby limiting side effects.
1149:"Endocrinology & Metabolism"
755:. J Obes Wt Loss Ther 3 (166), 2
753:Lean on Leptin or Lean for Sugar
471:American Physiological Societies
433:. Photographer Roberto Kelleher
284:Instituto Gulbenkian de Ciência
628:Andreia Barateiro, Ines Mahú,
230:on which her lab has authored
90:University of Lisbon, Portugal
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1335:Rockefeller University alumni
663:Nilay Yapici, Manuel Zimmer,
291:near the Portuguese capital,
258:where she authored papers in
196:chemical signals sent by the
340:by not interacting with the
98:Neuroscientist, Physiologist
1340:Portuguese women scientists
1330:University of Lisbon alumni
396:Pfizer ASPIRE Obesity Award
311:In 2018, Domingos moved to
216:The University of Cambridge
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1300:Domingos discusses obesity
832:10.1016/j.cell.2015.08.055
550:O'Brien CJO, Haberman ER,
516:Peer reviewed publications
419:Media & Research Talks
143:Lady Margaret Hall, Oxford
1232:10.1101/2023.05.09.539963
704: Mattias C Larsson,
392:European Research Council
315:in the UK to work at the
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16:Portuguese neuroscientist
493:Domingos' Google Scholar
383:to fund their projects.
369:British Heart Foundation
1325:Portuguese neurologists
322:University of Cambridge
1247:Cite journal requires
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346:cardiovascular systems
248:Rockefeller University
224:cardiovascular systems
150:Rockefeller University
1226:: 2023.05.09.539963.
526:56.4 (2023): 747-749.
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338:sympathomimetic drugs
228:Neuroimmunometabolism
208:Sympathomimetic drugs
171:, interacts with the
355:Awards & Funding
244:University of Lisbon
165:Gulbenkian Institute
139:University of Oxford
74:Ana Domingo's Jansen
697:Elane Fishilevich,
381:Croucher Foundation
365:Wellcome Immunology
276:Jeffrey M. Friedman
270:Career and Research
212:sympathetic neurons
198:sympathetic neurons
178:sympathetic neurons
1202:scholar.google.com
1056:patents.justia.com
543:O'Brien CJO &
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330:anti-obesity drugs
256:Leslie B. Vosshall
173:sympathetic nerves
114:Studies on obesity
1080:www.dpag.ox.ac.uk
1032:www.dpag.ox.ac.uk
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572:Emma R Haberman,
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