1076:
518:
the desired drugs in the vicinity of a growing cancer mass, preventing it from being able to gain access to oxygen and ultimately starving the cancer cells. This method has been shown to work both in vitro and in vivo in mice models, with very promising results. It is expected that this method will become commonplace for treatment of various cancer types in humans in the future.
1180:
Because these drugs act on parts of the blood and blood vessels, they tend to have side effects that affect these processes. Aside from problems with hemorrhage and hypertension, less common side effects of these drugs include dry, itchy skin, hand-foot syndrome (tender, thickened areas on the skin,
710:
never fully mature, and are thus destroyed by angiogenesis inhibitors. Angiogenesis inhibitors are also used as treatment for the wet form of macular degeneration. By blocking VEGF, inhibitors can cause regression of the abnormal blood vessels in the retina and improve vision when injected directly
183:
because they are less toxic and less likely to lead to drug resistance than some exogenous inhibitors. However, the therapeutic use of endogenous inhibitors has disadvantages. In animal studies, high doses of inhibitors were required to prevent tumor growth and the use of endogenous inhibitors would
92:
When a tumor stimulates the growth of new vessels, it is said to have undergone an 'angiogenic switch'. The principal stimulus for this angiogenic switch appears to be oxygen deprivation, although other stimuli such as inflammation, oncogenic mutations and mechanical stress may also play a role. The
1162:
Bleeding is one of the most difficult side effects to manage; this complication is somewhat inherent to the effectiveness of the drug. Bevacizumab has been shown to be the drug most likely to cause bleeding complications. While the mechanisms of bleeding induced by anti-VEGF agents are complicated
141:
Inhibiting angiogenesis requires treatment with anti-angiogenic factors, or drugs which reduce the production of pro-angiogenic factors, prevent them binding to their receptors or block their actions. Inhibition of the VEGF pathway has become the focus of angiogenesis research, as approximately 60%
517:
and removing any harmful virulence genes. A target can also be added to the outside of the bacteria so that they are sent to the correct organ in the body. The bacteria can then be injected into the patient and they will locate themselves to the tumor site, where they release a continual supply of
1120:
is one such antiangiogenic agent. Thalidomide was given to pregnant women to treat nausea. However, when pregnant women take an antiangiogenic agent, the developing fetus will not form blood vessels properly, thereby preventing the proper development of fetal limbs and circulatory systems. In the
162:
Angiogenesis is regulated by the activity of endogenous stimulators and inhibitors. Endogenous inhibitors, found in the body naturally, are involved in the day-to-day process of regulating blood vessel formation. Endogenous inhibitors are often derived from the extracellular matrix or basement
694:
Research and development in this field has been driven largely by the desire to find better cancer treatments. Tumors cannot grow larger than 2mm without angiogenesis. By stopping the growth of blood vessels, scientists hope to cut the means by which tumors can nourish themselves and thus
2137:
Lee JS, Park BC, Ko YJ, Choi MK, Choi HG, Yong CS, Lee JS, Kim JA (December 2008). "Grifola frondosa (maitake mushroom) water extract inhibits vascular endothelial growth factor-induced angiogenesis through inhibition of reactive oxygen species and extracellular signal-regulated kinase
1097:, all of which promote angiogenesis. Bevacizumab (brand name Avastin) traps VEGF in the blood, lowering the binding of VEGF to its receptors. This results in reduced activation of the angiogenesis pathway, thus inhibiting new blood vessel formation in tumors.
1181:
sometimes with blisters on palms and soles), diarrhea, fatigue, and low blood counts. Angiogenesis inhibitors can also interfere with wound healing and cause cuts to re-open or bleed. Rarely, perforations (holes) in the intestines can occur.
2263:
Rodriguez SK, Guo W, Liu L, Band MA, Paulson EK, Meydani M (April 2006). "Green tea catechin, epigallocatechin-3-gallate, inhibits vascular endothelial growth factor angiogenic signaling by disrupting the formation of a receptor complex".
178:
During tumor growth, the action of angiogenesis stimulators surpasses the control of angiogenesis inhibitors, allowing for unregulated or less regulated blood vessel growth and formation. Endogenous inhibitors are attractive targets for
1163:
and not yet totally understood, the most accepted hypothesis is that VEGF could promote endothelial cell survival and integrity in the adult vasculature and its inhibition may decrease capacity for renewal of damaged endothelial cells.
76:" treatment applicable to many types of cancer, but the limitations of anti-angiogenic therapy have been shown in practice. Currently, angiogenesis inhibitors are recognized for their improvement of cancer immunotherapy by overcoming
1804:
Xu, Y. F., Zhu, L. P., Hu, B., Fu, G. F., Zhang, H. Y., Wang, J. J., & Xu, G. X. (2007). A new expression plasmid in
Bifidobacterium longum as a delivery system of endostatin for cancer gene therapy. Cancer gene therapy, 14(2),
1171:
In a study done by ML Maitland, a mean blood pressure increase of 8.2 mm Hg systolic and 6.5 mm Hg diastolic was reported in the first 24 hours after the first treatment with sorafenib, a VEGF pathway inhibitor.
1149:, restrict the sprouting of blood vessels to gliomas (brain tumors) implanted under the skin of mice, by inhibiting the expression of genes needed for the production of vascular endothelial growth factor (VEGF).
1079:
Mechanism of action of angiogenesis inhibitors. Bevacizumab binds to VEGF inhibiting its ability to bind to and activate VEGF receptors. Sunitinib and
Sorafenib inhibit VEGF receptors. Sorafenib also acts
1991:
Stanley G, Harvey K, Slivova V, Jiang J, Sliva D (April 2005). "Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-beta1 from prostate cancer cells".
1108:
was approved by the FDA, becoming the first commercially available anti-angiogenesis drug. FDA approval of
Avastin for breast cancer treatment was later revoked on November 18, 2011.
2313:
1795:
Gardlik, R., Behuliak, M., Palffy, R., Celec, P., & Li, C. J. (2011). Gene therapy for cancer: bacteria-mediated anti-angiogenesis therapy. Gene therapy, 18(5), 425-431.
1263:
Huinen, Z., et al., Anti-angiogenic agents - overcoming tumor endothelial cell anergy and improving immunotherapy outcomes. Nat. Rev. Clin. Oncol., 2021. 18(8): p. 527-540.
2841:
Blázquez C, González-Feria L, Alvarez L, Haro A, Casanova ML, Guzmán M (August 2004). "Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas".
3292:
878:
2110:
Kobayashi H, Matsunaga K, Oguchi Y (1995). "Antimetastatic effects of PSK (Krestin), a protein-bound polysaccharide obtained from basidiomycetes: an overview".
1093:
and other VEGF receptors in endothelial cells, VEGF can trigger multiple cellular responses like promoting cell survival, preventing apoptosis, and remodeling
1293:
1251:
Fukumura, D., et al., Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges. Nat Rev Clin Oncol, 2018. 15(5): p. 325-340.
3060:
3231:
325:
543:. In particular, the following foods contain significant inhibitors and have been suggested as part of a healthy diet for this and other benefits:
1190:
1956:
Liu Z, Schwimer J, Liu D, Greenway FL, Anthony CT, Woltering EA (2005). "Black
Raspberry Extract and Fractions Contain Angiogenesis Inhibitors".
3206:
2378:"10-Hydroxy-2-decenoic acid, a major fatty acid from royal jelly, inhibits VEGF-induced angiogenesis in human umbilical vein endothelial cells"
321:
2310:
2976:
Molecular
Phenotypes of Endothelial Cells in Malignant Tumors. In: Akslen, L.A., Watnick, R.S. (eds) Biomarkers of the Tumor Microenvironment
1422:
2175:"Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling"
2466:
Heier JS (May 2013). "Neovascular age-related macular degeneration: individualizing therapy in the era of anti-angiogenic treatments".
3327:
885:
623:
595:
425:
314:
212:
2644:
Goya Grocin A, Kallemeijn WW, Tate EW (October 2021). "Targeting methionine aminopeptidase 2 in cancer, obesity, and autoimmunity".
2026:
Fisher M, Yang LX (May 2002). "Anticancer effects and mechanisms of polysaccharide-K (PSK): implications of cancer immunotherapy".
2501:
Chong CR, Xu J, Lu J, Bhat S, Sullivan DJ, Liu JO (April 2007). "Inhibition of angiogenesis by the antifungal drug itraconazole".
2333:
Jeong SJ, Koh W, Lee EO, Lee HJ, Lee HJ, Bae H, Lü J, Kim SH (January 2011). "Antiangiogenic phytochemicals and medicinal herbs".
1714:
Kamphaus GD, Colorado PC, Panka DJ, Hopfer H, Ramchandran R, Torre A, Maeshima Y, Mier JW, Sukhatme VP, Kalluri R (January 2000).
3429:
3408:
1314:
Ng EW, Adamis AP (June 2005). "Targeting angiogenesis, the underlying disorder in neovascular age-related macular degeneration".
172:
3009:
2922:
Maitland ML, Kasza KE, Karrison T, Moshier K, Sit L, Black HR, Undevia SD, Stadler WM, Elliott WJ, Ratain MJ (October 2009).
2701:
484:
3053:
2999:
1275:
Dudley, A.C. & Griffioen, A.W., Pathological angiogenesis: mechanisms and therapeutic strategies. Angiogenesis, 2023.
93:
angiogenic switch leads to tumor expression of pro-angiogenic factors and increased tumor vascularization. Specifically,
2055:"Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cancer"
531:
Some common components of human diets also act as mild angiogenesis inhibitors and have therefore been proposed for
2222:
Lee YS, Kang YH, Jung JY, Lee S, Ohuchi K, Shin KH, Kang IJ, Park JH, Shin HK, Lim SS, et al. (October 2008).
1603:"Vascular endothelial growth factor-targeted therapy in renal cell carcinoma: current status and future directions"
147:
1116:
Despite the therapeutic potential of anti-angiogenesis drugs, they can also be harmful when used inappropriately.
3023:
1858:"Isolation of an anti-angiogenic substance from Agaricus blazei Murill: its antitumor and antimetastatic actions"
1817:"Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer"
3175:
3019:
1289:
121:
proliferation, migration and invasion resulting in new vascular structures sprouting from nearby blood vessels.
3046:
3032:
702:
In addition to their use as anti-cancer drugs, angiogenesis inhibitors are being investigated for their use as
110:
1816:
77:
2779:
122:
3267:
2924:"Ambulatory monitoring detects sorafenib-induced blood pressure elevations on the first day of treatment"
566:
142:
of malignant tumors express high concentrations of VEGF. Strategies to inhibit the VEGF pathway include
483:
A recent method for the delivery of anti-angiogenesis factors to tumor regions in cancer patients uses
3287:
2598:
771:
130:
81:
1287:
Cancer.com . National Cancer
Institute at the National Institutes of Health; 2011 . Available from:
3028:
606:
474:
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1897:
1563:
1383:
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912:
581:
250:
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61:
and other favorable processes, certain types of angiogenesis are associated with the growth of
3332:
3165:
2953:
2904:
2858:
2823:
2761:
2713:
2671:
2626:
2567:
2518:
2483:
2448:
2407:
2350:
2281:
2245:
2204:
2155:
2119:
2084:
2035:
2008:
1973:
1938:
1889:
1838:
1778:
1737:
1670:
1624:
1583:
1520:
1502:
1463:
1418:
1401:
Milosevic V, Edelmann RJ, Fosse JH, Östman A, Akslen LA (2022), Akslen LA, Watnick RS (eds.),
1375:
1331:
1234:
870:
827:
655:
630:
571:
304:
1446:
Cao Y (April 2001). "Endogenous angiogenesis inhibitors and their therapeutic implications".
1371:
3307:
3201:
3190:
3120:
3110:
2943:
2935:
2896:
2850:
2813:
2751:
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2653:
2616:
2606:
2557:
2549:
2510:
2475:
2438:
2397:
2389:
2342:
2273:
2235:
2194:
2186:
2147:
2074:
2066:
2000:
1965:
1928:
1917:"Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action"
1879:
1869:
1828:
1768:
1727:
1660:
1614:
1575:
1510:
1494:
1455:
1410:
1367:
1323:
1224:
955:
inhibit cell migration, cell proliferation, cell adhesion and survival of endothelial cells
807:
611:
591:
390:
356:
348:
236:
164:
118:
51:
3297:
3115:
2317:
1101:
763:
532:
352:
2995:
2738:
Rosenfeld PJ, Brown DM, Heier JS, Boyer DS, Kaiser PK, Chung CY, Kim RY (October 2006).
2602:
2079:
2054:
1884:
1857:
1538:
917:
inhibit cell proliferation and cell migration and induce apoptosis of endothelial cells
3377:
3372:
3312:
3254:
3184:
3140:
3135:
2948:
2923:
2621:
2586:
2562:
2537:
2402:
2377:
2199:
2174:
1874:
1515:
1482:
970:
950:
851:
817:
712:
707:
682:
499:
386:
372:
368:
246:
240:
229:
223:
208:
180:
2900:
1773:
1756:
1459:
1327:
812:
downregulate angiogenesis stimulators and inhibit cell migration of endothelial cells
3423:
3130:
1564:"Bevacizumab (Avastin), a humanized anti-VEGF monoclonal antibody for cancer therapy"
800:
755:
672:
645:
364:
254:
168:
73:
58:
1498:
1387:
3403:
3317:
3100:
2992:
2870:
2538:"Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer"
2293:
1901:
1142:
1094:
745:
703:
547:
540:
294:
35:
2939:
2854:
2802:"Thalidomide: the tragedy of birth defects and the effective treatment of disease"
2688:
2553:
2362:
2096:
1665:
1648:
1619:
1602:
2479:
3367:
3352:
3282:
3277:
3196:
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1414:
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1117:
1023:
1011:
998:
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892:
734:
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678:
665:
493:
432:
382:
265:
258:
151:
43:
2657:
2591:
Proceedings of the
National Academy of Sciences of the United States of America
2443:
2426:
2004:
1579:
779:
inhibitors, inhibit cell proliferation and cell migration of endothelial cells
3302:
3211:
3105:
2979:
2974:
Milosevic, V., Edelmann, R.J., Fosse, J.H., Östman, A., Akslen, L.A. (2022).
2587:"Cholesterol trafficking is required for mTOR activation in endothelial cells"
2311:
Antiangiogenic
Substances in Blackberries, Licorice May Aid Cancer Prevention.
2070:
1757:"Proliferin secreted by cultured cells binds to mannose 6-phosphate receptors"
1716:"Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth"
1689:
1402:
1126:
1064:
988:
902:
788:
575:
536:
510:
505:
290:
280:
143:
102:
84:
in the eye, and other diseases that involve a proliferation of blood vessels.
72:
treatment. Angiogenesis inhibitors were once thought to have potential as a "
39:
2887:
Elice F, Rodeghiero F (April 2012). "Side effects of anti-angiogenic drugs".
2053:
Oba K, Teramukai S, Kobayashi M, Matsui T, Kodera Y, Sakamoto J (June 2007).
1506:
907:
inhibit cell migration, cell proliferation and survival of endothelial cells
285:
inhibit cell migration, cell proliferation and survival of endothelial cells
3337:
3170:
2818:
2801:
2666:
2611:
1933:
1916:
1276:
1264:
1252:
1146:
1054:
1044:
1033:
960:
651:
641:
635:
559:
514:
452:
401:
272:
154:. Bevacizumab binds to VEGF and inhibits it from binding to VEGF receptors.
126:
98:
62:
2957:
2908:
2862:
2827:
2765:
2717:
2675:
2630:
2571:
2522:
2487:
2452:
2411:
2354:
2285:
2249:
2208:
2190:
2159:
2088:
2039:
2012:
1977:
1942:
1893:
1842:
1741:
1732:
1715:
1674:
1628:
1587:
1524:
1467:
1379:
1335:
1238:
1137:
According to a study published in the August 15, 2004 issue of the journal
129:, are critical to the attachment and migration of endothelial cells to the
17:
2393:
2224:"Protein glycation inhibitors from the fruiting body of Phellinus linteus"
2151:
2123:
1782:
3322:
3077:
2756:
2739:
661:
599:
438:
114:
2376:
Izuta H, Chikaraishi Y, Shimazawa M, Mishima S, Hara H (December 2009).
2240:
2223:
1833:
3382:
3347:
3272:
3241:
3221:
1105:
864:
837:
784:
618:
339:
335:
199:
2514:
2277:
1969:
68:. Thus angiogenesis inhibitors have been closely studied for possible
3342:
3155:
3150:
3145:
3125:
3085:
2991:
The idea of antiangiogenesis was pioneered by Dr. Judah
Folkman. See
2346:
1642:
1640:
1638:
897:
inhibit cell proliferation and induce apoptosis of endothelial cells
844:
776:
555:
460:
446:
360:
150:. The most widely used VEGF pathway inhibitor on the market today is
69:
65:
1229:
1212:
1539:"Avastin (bevacizumab) - Angiogenesis Inhibitor and Cancer Therapy"
3387:
3226:
3038:
2173:
Sliva D, Jedinak A, Kawasaki J, Harvey K, Slivova V (April 2008).
1856:
Kimura Y, Kido T, Takaku T, Sumiyoshi M, Baba K (September 2004).
1358:
1090:
1074:
751:
203:
94:
47:
1121:
late 1950s and early 1960s, thousands of children were born with
146:
directed against VEGF or VEGFR, soluble VEGFR/VEGFR hybrids, and
3216:
759:
551:
411:
310:
216:
106:
42:
and a normal part of the body's control and others are obtained
3042:
1403:"Molecular Phenotypes of Endothelial Cells in Malignant Tumors"
377:
inhibit cell migration of endothelial cells, downregulate bFGF
2740:"Ranibizumab for neovascular age-related macular degeneration"
34:
is a substance that inhibits the growth of new blood vessels (
2702:"Evolving Therapeutic Paradigms for Advanced Prostate Cancer"
2536:
Aftab BT, Dobromilskaya I, Liu JO, Rudin CM (November 2011).
634:
mushrooms (via active substance
Interfungins A inhibition of
80:. Angiogenesis inhibitors are also used to effectively treat
1448:
The International Journal of Biochemistry & Cell Biology
1409:, Cham: Springer International Publishing, pp. 31–52,
762:
signaling, endothelial cell proliferation, cell migration,
1815:
Farina HG, Pomies M, Alonso DF, Gomez DE (October 2006).
1481:
Kazazi-Hyseni F, Beijnen JH, Schellens JH (2010-08-01).
1356:
Folkman J (2004). "Endogenous angiogenesis inhibitors".
3013:
3003:
466:
inhibits endothelial cell migration, induces apoptosis
27:
Substance that inhibits the growth of new blood vessels
2382:
Evidence-Based Complementary and Alternative Medicine
935:
copper chelation which inhibits blood vessel growth
509:
by adding genes for anti-angiogenic factors such as
3396:
3240:
3076:
1993:
Biochemical and Biophysical Research Communications
1568:
Biochemical and Biophysical Research Communications
163:membrane proteins and function by interfering with
3020:Angiogenesis Inhibitors in the Treatment of Cancer
2431:Arteriosclerosis, Thrombosis, and Vascular Biology
2427:"Targeting angiogenesis as treatment for obesity"
3293:Cartilage-Derived Angiogenesis Inhibitory Factor
2112:Cancer Epidemiology, Biomarkers & Prevention
945:inhibit cell proliferation of endothelial cells
925:inhibit cell proliferation of endothelial cells
879:Cartilage-Derived Angiogenesis Inhibitory Factor
416:affects cell proliferation of endothelial cells
396:inhibit cell proliferation of endothelial cells
299:inhibit cell proliferation of endothelial cells
766:formation, and tumor associated angiogenesis.
3054:
832:inhibits binding of angiogenesis stimulators
8:
2305:
2303:
993:inhibit cell migration of endothelial cells
330:inhibit cell migration of endothelial cells
2980:https://doi.org/10.1007/978-3-030-98950-7_3
2585:Xu J, Dang Y, Ren YR, Liu JO (March 2010).
1351:
1349:
1347:
1345:
822:stimulate angiogenesis inhibitor formation
3061:
3047:
3039:
1958:Journal of Agricultural and Food Chemistry
167:formation and migration, endothelial tube
3031:at the U.S. National Library of Medicine
2947:
2817:
2755:
2665:
2620:
2610:
2561:
2442:
2401:
2239:
2198:
2078:
1932:
1883:
1873:
1832:
1772:
1731:
1664:
1618:
1514:
1228:
175:of genes expressed in endothelial cells.
57:While angiogenesis is a critical part of
2882:
2880:
2228:Biological & Pharmaceutical Bulletin
1915:Takaku T, Kimura Y, Okuda H (May 2001).
1562:Ferrara N, Hillan KJ, Novotny W (2005).
1407:Biomarkers of the Tumor Microenvironment
1372:10.1111/j.1600-0463.2004.apm11207-0809.x
722:
186:
3010:Angiogenesis Inhibitors for Eye Disease
1649:"Endogenous inhibitors of angiogenesis"
1647:Nyberg P, Xie L, Kalluri R (May 2005).
1203:
1191:Brain-specific angiogenesis inhibitor 1
1129:, as a consequence of thalidomide use.
487:that are able to colonize solid tumors
983:induce apoptosis of endothelial cells
271:inhibit cell proliferation and induce
105:, vascular endothelial growth factor (
1441:
1439:
113:), and transforming growth factor-β (
97:cells release various pro-angiogenic
7:
2689:Ramucirumab (Cyramza) package insert
1690:"Vascular Endothelial Growth Factor"
38:). Some angiogenesis inhibitors are
3328:matrix metalloproteinase inhibitors
2744:The New England Journal of Medicine
2700:Ruch JM, Hussain MH (15 May 2011).
1761:The Journal of Biological Chemistry
1720:The Journal of Biological Chemistry
1213:"Cutting off cancer's supply lines"
886:matrix metalloproteinase inhibitors
3000:Angiogenesis Inhibitors for Cancer
2646:Trends in Pharmacological Sciences
1875:10.1111/j.1349-7006.2004.tb03258.x
570:mushrooms (contain the inhibitors
25:
1316:Canadian Journal of Ophthalmology
2800:Kim JH, Scialli AR (July 2011).
1755:Lee SJ, Nathans D (March 1988).
1694:Madame Curie Bioscience Database
558:, (which contain the inhibitor "
424:inhibit binding and activity of
2266:International Journal of Cancer
1499:10.1634/theoncologist.2009-0317
1296:from the original on 2015-02-08
1277:doi: 10.1007/s10456-023-09876-7
1265:doi: 10.1038/s41571-021-00496-y
1253:doi: 10.1038/nrclinonc.2018.29
1:
2940:10.1158/1078-0432.CCR-09-0058
2901:10.1016/S0049-3848(12)70016-6
2855:10.1158/0008-5472.CAN-03-3927
2554:10.1158/0008-5472.CAN-11-0691
1774:10.1016/S0021-9258(18)69101-X
1666:10.1158/0008-5472.CAN-04-2427
1620:10.1158/1078-0432.CCR-06-1989
1460:10.1016/s1357-2725(01)00023-1
1328:10.1016/S0008-4182(05)80078-X
1153:General side effects of drugs
622:mushrooms (via inhibition of
485:genetically modified bacteria
109:), fibroblast growth factor (
2480:10.1016/j.ophtha.2013.01.059
2425:Bruemmer D (February 2012).
2321:The Angiogenesis Foundation.
1145:, the active ingredients in
706:agents, as blood vessels in
3014:The Angiogenesis Foundation
3004:The Angiogenesis Foundation
2781:FDA News Release on Avastin
1415:10.1007/978-3-030-98950-7_3
777:Methionine aminopeptidase 2
3451:
3176:proliferin-related protein
2658:10.1016/j.tips.2021.07.004
2444:10.1161/ATVBAHA.111.241992
2005:10.1016/j.bbrc.2005.02.116
1580:10.1016/j.bbrc.2005.05.132
539:through the inhibition of
477:binding lysosomal protein
471:proliferin-related protein
148:tyrosine kinase inhibitors
3024:National Cancer Institute
2179:British Journal of Cancer
2140:Journal of Medicinal Food
2071:10.1007/s00262-006-0248-1
2059:Cancer Immunol Immunother
1601:Rini BI (February 2007).
1290:"Angiogenesis Inhibitors"
1038:
868:
831:
775:
459:canstatin (a fragment of
3033:Medical Subject Headings
2928:Clinical Cancer Research
1921:The Journal of Nutrition
1607:Clinical Cancer Research
1211:Hayden EC (April 2009).
1176:Less common side effects
1167:Increased blood pressure
3430:Angiogenesis inhibitors
3409:Angiogenesis inhibitors
3029:Angiogenesis+Inhibitors
2612:10.1073/pnas.0910872107
863:angiostatic steroids +
137:VEGF pathway inhibition
123:Cell adhesion molecules
78:endothelial cell anergy
2806:Toxicological Sciences
2191:10.1038/sj.bjc.6604319
1733:10.1074/jbc.275.2.1209
1081:
32:angiogenesis inhibitor
2819:10.1093/toxsci/kfr088
2335:Phytotherapy Research
2152:10.1089/jmf.2007.0629
1934:10.1093/jn/131.5.1409
1543:Clinical Trials Arena
1078:
567:Agaricus subrufescens
275:of endothelial cells
268:and related molecules
184:likely be long-term.
158:Endogenous regulation
3288:carboxyamidotriazole
3268:angiostatic steroids
2757:10.1056/NEJMoa054481
2503:ACS Chemical Biology
772:carboxyamidotriazole
572:sodium pyroglutamate
535:, the prevention of
522:Exogenous regulation
309:inhibits binding of
131:extracellular matrix
82:macular degeneration
48:pharmaceutical drugs
2889:Thrombosis Research
2712:(6): 496–504, 508.
2603:2010PNAS..107.4764X
2394:10.1093/ecam/nem152
2241:10.1248/bpb.31.1968
2028:Anticancer Research
1834:10.3892/or.16.4.885
1696:, Landes Bioscience
1089:Through binding to
1003:inhibition of VEGFR
675:and medicinal herbs
607:Trametes versicolor
594:(via inhibition of
475:mannose 6-phosphate
117:). These stimulate
101:factors (including
88:Mechanism of action
3363:tetrathiomolybdate
3250:2-Methoxyestradiol
2978:. Springer, Cham.
2474:(5 Suppl): S23–5.
2316:2010-02-14 at the
2138:phosphorylation".
1100:After a series of
1082:
931:tetrathiomolybdate
913:2-methoxyestradiol
858:VEGFR antagonists
586:Rubus occidentalis
251:cell proliferation
3417:
3416:
3388:VEGFR antagonists
3333:platelet factor-4
3166:platelet factor-4
2515:10.1021/cb600362d
2309:Smith, Roderick.
2278:10.1002/ijc.21545
1970:10.1021/jf048585u
1964:(10): 3909–3915.
1424:978-3-030-98950-7
1073:
1072:
871:basement membrane
828:platelet factor-4
754:phosphorylation,
656:glycyrrhizic acid
631:Phellinus linteus
592:Lingzhi mushrooms
481:
480:
305:platelet factor-4
259:endothelial cells
16:(Redirected from
3442:
3202:Thrombospondin 1
3191:antithrombin III
3063:
3056:
3049:
3040:
2962:
2961:
2951:
2919:
2913:
2912:
2884:
2875:
2874:
2838:
2832:
2831:
2821:
2797:
2791:
2790:
2789:
2788:
2776:
2770:
2769:
2759:
2735:
2729:
2728:
2726:
2724:
2697:
2691:
2686:
2680:
2679:
2669:
2641:
2635:
2634:
2624:
2614:
2582:
2576:
2575:
2565:
2533:
2527:
2526:
2498:
2492:
2491:
2463:
2457:
2456:
2446:
2422:
2416:
2415:
2405:
2373:
2367:
2366:
2347:10.1002/ptr.3224
2330:
2324:
2307:
2298:
2297:
2260:
2254:
2253:
2243:
2219:
2213:
2212:
2202:
2170:
2164:
2163:
2134:
2128:
2127:
2107:
2101:
2100:
2082:
2050:
2044:
2043:
2023:
2017:
2016:
1988:
1982:
1981:
1953:
1947:
1946:
1936:
1912:
1906:
1905:
1887:
1877:
1853:
1847:
1846:
1836:
1821:Oncology Reports
1812:
1806:
1802:
1796:
1793:
1787:
1786:
1776:
1752:
1746:
1745:
1735:
1711:
1705:
1704:
1703:
1701:
1685:
1679:
1678:
1668:
1644:
1633:
1632:
1622:
1598:
1592:
1591:
1559:
1553:
1552:
1550:
1549:
1535:
1529:
1528:
1518:
1478:
1472:
1471:
1443:
1434:
1433:
1432:
1431:
1398:
1392:
1391:
1366:(7–8): 496–507.
1353:
1340:
1339:
1311:
1305:
1304:
1302:
1301:
1285:
1279:
1273:
1267:
1261:
1255:
1249:
1243:
1242:
1232:
1208:
1039:inhibit kinases
723:
612:Polysaccharide-K
391:antithrombin III
257:and survival of
187:
165:endothelial cell
119:endothelial cell
21:
3450:
3449:
3445:
3444:
3443:
3441:
3440:
3439:
3420:
3419:
3418:
3413:
3392:
3262:
3258:
3236:
3222:soluble VEGFR-1
3072:
3070:Antiangiogenics
3067:
2988:
2971:
2969:Further reading
2966:
2965:
2921:
2920:
2916:
2886:
2885:
2878:
2849:(16): 5617–23.
2843:Cancer Research
2840:
2839:
2835:
2799:
2798:
2794:
2786:
2784:
2778:
2777:
2773:
2750:(14): 1419–31.
2737:
2736:
2732:
2722:
2720:
2699:
2698:
2694:
2687:
2683:
2652:(10): 870–882.
2643:
2642:
2638:
2584:
2583:
2579:
2548:(21): 6764–72.
2542:Cancer Research
2535:
2534:
2530:
2500:
2499:
2495:
2465:
2464:
2460:
2424:
2423:
2419:
2375:
2374:
2370:
2332:
2331:
2327:
2318:Wayback Machine
2308:
2301:
2262:
2261:
2257:
2234:(10): 1968–72.
2221:
2220:
2216:
2172:
2171:
2167:
2136:
2135:
2131:
2109:
2108:
2104:
2052:
2051:
2047:
2025:
2024:
2020:
1990:
1989:
1985:
1955:
1954:
1950:
1914:
1913:
1909:
1855:
1854:
1850:
1814:
1813:
1809:
1803:
1799:
1794:
1790:
1754:
1753:
1749:
1713:
1712:
1708:
1699:
1697:
1688:Hugo H. Marti,
1687:
1686:
1682:
1659:(10): 3967–79.
1653:Cancer Research
1646:
1645:
1636:
1613:(4): 1098–106.
1600:
1599:
1595:
1561:
1560:
1556:
1547:
1545:
1537:
1536:
1532:
1480:
1479:
1475:
1445:
1444:
1437:
1429:
1427:
1425:
1400:
1399:
1395:
1355:
1354:
1343:
1313:
1312:
1308:
1299:
1297:
1288:
1286:
1282:
1274:
1270:
1262:
1258:
1250:
1246:
1230:10.1038/458686b
1223:(7239): 686–7.
1210:
1209:
1205:
1200:
1187:
1178:
1169:
1160:
1155:
1139:Cancer Research
1135:
1125:, most notably
1114:
1102:clinical trials
1087:
1006:
978:
974:
721:
692:
671:Antiangiogenic
582:Black raspberry
533:angioprevention
529:
524:
209:decoy receptors
173:down-regulation
160:
139:
90:
28:
23:
22:
15:
12:
11:
5:
3448:
3446:
3438:
3437:
3432:
3422:
3421:
3415:
3414:
3412:
3411:
3406:
3400:
3398:
3394:
3393:
3391:
3390:
3385:
3380:
3378:thrombospondin
3375:
3373:thrombospondin
3370:
3365:
3360:
3355:
3350:
3345:
3340:
3335:
3330:
3325:
3320:
3315:
3310:
3305:
3300:
3295:
3290:
3285:
3280:
3275:
3270:
3265:
3260:
3256:
3252:
3246:
3244:
3238:
3237:
3235:
3234:
3229:
3224:
3219:
3214:
3209:
3204:
3199:
3194:
3188:
3185:kringle domain
3178:
3173:
3168:
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3123:
3118:
3113:
3108:
3103:
3098:
3093:
3088:
3086:Angiopoietin 2
3082:
3080:
3074:
3073:
3068:
3066:
3065:
3058:
3051:
3043:
3037:
3036:
3026:
3017:
3016:, 23 June 2009
3007:
3006:, 23 June 2009
2997:
2987:
2986:External links
2984:
2983:
2982:
2970:
2967:
2964:
2963:
2934:(19): 6250–7.
2914:
2876:
2833:
2792:
2771:
2730:
2692:
2681:
2667:10044/1/102175
2636:
2597:(10): 4764–9.
2577:
2528:
2493:
2458:
2417:
2368:
2325:
2299:
2272:(7): 1635–44.
2255:
2214:
2185:(8): 1348–56.
2165:
2129:
2102:
2045:
2034:(3): 1737–54.
2018:
1983:
1948:
1927:(5): 1409–13.
1907:
1862:Cancer Science
1848:
1807:
1797:
1788:
1747:
1726:(2): 1209–15.
1706:
1680:
1634:
1593:
1574:(2): 328–335.
1554:
1530:
1493:(8): 819–825.
1487:The Oncologist
1473:
1435:
1423:
1393:
1341:
1306:
1280:
1268:
1256:
1244:
1202:
1201:
1199:
1196:
1195:
1194:
1186:
1183:
1177:
1174:
1168:
1165:
1159:
1156:
1154:
1151:
1134:
1131:
1113:
1110:
1086:
1083:
1071:
1070:
1068:
1061:
1060:
1058:
1051:
1050:
1048:
1041:
1040:
1037:
1030:
1029:
1026:
1020:
1019:
1014:
1008:
1007:
1004:
1001:
995:
994:
991:
985:
984:
981:
976:
972:
967:
966:
963:
957:
956:
953:
951:thrombospondin
947:
946:
943:
937:
936:
933:
927:
926:
923:
919:
918:
915:
909:
908:
905:
899:
898:
895:
889:
888:
882:
881:
875:
874:
867:
860:
859:
855:
854:
852:thrombospondin
848:
847:
841:
840:
834:
833:
830:
824:
823:
820:
814:
813:
810:
804:
803:
797:
793:
792:
787:(an analog of
781:
780:
774:
768:
767:
748:
742:
741:
738:
731:
730:
727:
720:
717:
713:vitreous humor
708:adipose tissue
691:
688:
687:
686:
683:Queen bee acid
676:
673:phytochemicals
669:
659:
649:
639:
627:
615:
603:
589:
579:
563:
528:
525:
523:
520:
500:Bifidobacteria
479:
478:
472:
468:
467:
464:
456:
455:
449:
443:
442:
435:
429:
428:
422:
418:
417:
414:
408:
407:
404:
398:
397:
394:
387:kringle domain
379:
378:
375:
345:
344:
342:
332:
331:
328:
318:
317:
307:
301:
300:
297:
287:
286:
283:
277:
276:
269:
262:
261:
247:cell migration
243:
233:
232:
230:angiopoietin 1
228:antagonist of
226:
224:Angiopoietin 2
220:
219:
206:
195:
194:
191:
181:cancer therapy
159:
156:
138:
135:
89:
86:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3447:
3436:
3433:
3431:
3428:
3427:
3425:
3410:
3407:
3405:
3402:
3401:
3399:
3395:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
3364:
3361:
3359:
3356:
3354:
3351:
3349:
3346:
3344:
3341:
3339:
3336:
3334:
3331:
3329:
3326:
3324:
3321:
3319:
3316:
3314:
3311:
3309:
3306:
3304:
3301:
3299:
3296:
3294:
3291:
3289:
3286:
3284:
3281:
3279:
3276:
3274:
3271:
3269:
3266:
3264:
3253:
3251:
3248:
3247:
3245:
3243:
3239:
3233:
3230:
3228:
3225:
3223:
3220:
3218:
3215:
3213:
3210:
3208:
3205:
3203:
3200:
3198:
3195:
3192:
3189:
3186:
3182:
3179:
3177:
3174:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3124:
3122:
3119:
3117:
3114:
3112:
3109:
3107:
3104:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3084:
3083:
3081:
3079:
3075:
3071:
3064:
3059:
3057:
3052:
3050:
3045:
3044:
3041:
3034:
3030:
3027:
3025:
3021:
3018:
3015:
3011:
3008:
3005:
3001:
2998:
2996:
2993:
2990:
2989:
2985:
2981:
2977:
2973:
2972:
2968:
2959:
2955:
2950:
2945:
2941:
2937:
2933:
2929:
2925:
2918:
2915:
2910:
2906:
2902:
2898:
2894:
2890:
2883:
2881:
2877:
2872:
2868:
2864:
2860:
2856:
2852:
2848:
2844:
2837:
2834:
2829:
2825:
2820:
2815:
2811:
2807:
2803:
2796:
2793:
2783:
2782:
2775:
2772:
2767:
2763:
2758:
2753:
2749:
2745:
2741:
2734:
2731:
2719:
2715:
2711:
2707:
2703:
2696:
2693:
2690:
2685:
2682:
2677:
2673:
2668:
2663:
2659:
2655:
2651:
2647:
2640:
2637:
2632:
2628:
2623:
2618:
2613:
2608:
2604:
2600:
2596:
2592:
2588:
2581:
2578:
2573:
2569:
2564:
2559:
2555:
2551:
2547:
2543:
2539:
2532:
2529:
2524:
2520:
2516:
2512:
2509:(4): 263–70.
2508:
2504:
2497:
2494:
2489:
2485:
2481:
2477:
2473:
2469:
2468:Ophthalmology
2462:
2459:
2454:
2450:
2445:
2440:
2436:
2432:
2428:
2421:
2418:
2413:
2409:
2404:
2399:
2395:
2391:
2388:(4): 489–94.
2387:
2383:
2379:
2372:
2369:
2364:
2360:
2356:
2352:
2348:
2344:
2340:
2336:
2329:
2326:
2322:
2319:
2315:
2312:
2306:
2304:
2300:
2295:
2291:
2287:
2283:
2279:
2275:
2271:
2267:
2259:
2256:
2251:
2247:
2242:
2237:
2233:
2229:
2225:
2218:
2215:
2210:
2206:
2201:
2196:
2192:
2188:
2184:
2180:
2176:
2169:
2166:
2161:
2157:
2153:
2149:
2146:(4): 643–51.
2145:
2141:
2133:
2130:
2125:
2121:
2118:(3): 275–81.
2117:
2113:
2106:
2103:
2098:
2094:
2090:
2086:
2081:
2076:
2072:
2068:
2065:(6): 905–11.
2064:
2060:
2056:
2049:
2046:
2041:
2037:
2033:
2029:
2022:
2019:
2014:
2010:
2006:
2002:
1998:
1994:
1987:
1984:
1979:
1975:
1971:
1967:
1963:
1959:
1952:
1949:
1944:
1940:
1935:
1930:
1926:
1922:
1918:
1911:
1908:
1903:
1899:
1895:
1891:
1886:
1881:
1876:
1871:
1868:(9): 758–64.
1867:
1863:
1859:
1852:
1849:
1844:
1840:
1835:
1830:
1827:(4): 885–91.
1826:
1822:
1818:
1811:
1808:
1801:
1798:
1792:
1789:
1784:
1780:
1775:
1770:
1767:(7): 3521–7.
1766:
1762:
1758:
1751:
1748:
1743:
1739:
1734:
1729:
1725:
1721:
1717:
1710:
1707:
1695:
1691:
1684:
1681:
1676:
1672:
1667:
1662:
1658:
1654:
1650:
1643:
1641:
1639:
1635:
1630:
1626:
1621:
1616:
1612:
1608:
1604:
1597:
1594:
1589:
1585:
1581:
1577:
1573:
1569:
1565:
1558:
1555:
1544:
1540:
1534:
1531:
1526:
1522:
1517:
1512:
1508:
1504:
1500:
1496:
1492:
1488:
1484:
1483:"Bevacizumab"
1477:
1474:
1469:
1465:
1461:
1457:
1454:(4): 357–69.
1453:
1449:
1442:
1440:
1436:
1426:
1420:
1416:
1412:
1408:
1404:
1397:
1394:
1389:
1385:
1381:
1377:
1373:
1369:
1365:
1361:
1360:
1352:
1350:
1348:
1346:
1342:
1337:
1333:
1329:
1325:
1322:(3): 352–68.
1321:
1317:
1310:
1307:
1295:
1291:
1284:
1281:
1278:
1272:
1269:
1266:
1260:
1257:
1254:
1248:
1245:
1240:
1236:
1231:
1226:
1222:
1218:
1214:
1207:
1204:
1197:
1192:
1189:
1188:
1184:
1182:
1175:
1173:
1166:
1164:
1157:
1152:
1150:
1148:
1144:
1140:
1132:
1130:
1128:
1124:
1119:
1111:
1109:
1107:
1103:
1098:
1096:
1092:
1084:
1077:
1069:
1066:
1063:
1062:
1059:
1056:
1053:
1052:
1049:
1046:
1043:
1042:
1035:
1032:
1031:
1027:
1025:
1022:
1021:
1018:
1015:
1013:
1010:
1009:
1002:
1000:
997:
996:
992:
990:
987:
986:
982:
979:
969:
968:
964:
962:
959:
958:
954:
952:
949:
948:
944:
942:
939:
938:
934:
932:
929:
928:
924:
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839:
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835:
829:
826:
825:
821:
819:
816:
815:
811:
809:
806:
805:
802:
801:immune system
798:
795:
794:
790:
786:
783:
782:
778:
773:
770:
769:
765:
761:
757:
756:glycosylation
753:
749:
747:
744:
743:
739:
736:
733:
732:
728:
725:
724:
718:
716:
714:
709:
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684:
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650:
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640:
637:
633:
632:
628:
625:
621:
620:
616:
613:
609:
608:
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601:
597:
593:
590:
587:
583:
580:
577:
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569:
568:
564:
561:
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546:
545:
544:
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538:
534:
526:
521:
519:
516:
512:
508:
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501:
496:
495:
490:
486:
476:
473:
470:
469:
465:
462:
458:
457:
454:
450:
448:
445:
444:
440:
436:
434:
431:
430:
427:
423:
420:
419:
415:
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410:
409:
405:
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388:
384:
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366:
362:
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343:
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337:
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329:
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323:
320:
319:
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312:
308:
306:
303:
302:
298:
296:
292:
289:
288:
284:
282:
279:
278:
274:
270:
267:
264:
263:
260:
256:
255:cell adhesion
252:
248:
244:
242:
238:
235:
234:
231:
227:
225:
222:
221:
218:
214:
210:
207:
205:
201:
197:
196:
192:
189:
188:
185:
182:
176:
174:
170:
169:morphogenesis
166:
157:
155:
153:
149:
145:
136:
134:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
87:
85:
83:
79:
75:
74:silver bullet
71:
67:
64:
60:
59:wound healing
55:
53:
49:
45:
41:
37:
33:
19:
3404:Angiogenesis
3318:itraconazole
3101:calreticulin
3069:
2931:
2927:
2917:
2892:
2888:
2846:
2842:
2836:
2809:
2805:
2795:
2785:, retrieved
2780:
2774:
2747:
2743:
2733:
2721:. Retrieved
2709:
2705:
2695:
2684:
2649:
2645:
2639:
2594:
2590:
2580:
2545:
2541:
2531:
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2471:
2467:
2461:
2437:(2): 161–2.
2434:
2430:
2420:
2385:
2381:
2371:
2338:
2334:
2328:
2320:
2269:
2265:
2258:
2231:
2227:
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2182:
2178:
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2139:
2132:
2115:
2111:
2105:
2062:
2058:
2048:
2031:
2027:
2021:
1999:(1): 46–52.
1996:
1992:
1986:
1961:
1957:
1951:
1924:
1920:
1910:
1865:
1861:
1851:
1824:
1820:
1810:
1800:
1791:
1764:
1760:
1750:
1723:
1719:
1709:
1698:, retrieved
1693:
1683:
1656:
1652:
1610:
1606:
1596:
1571:
1567:
1557:
1546:. Retrieved
1542:
1533:
1490:
1486:
1476:
1451:
1447:
1428:, retrieved
1406:
1396:
1363:
1357:
1319:
1315:
1309:
1298:. Retrieved
1283:
1271:
1259:
1247:
1220:
1216:
1206:
1193:(and others)
1179:
1170:
1161:
1143:cannabinoids
1138:
1136:
1133:Cannabinoids
1115:
1099:
1095:cytoskeleton
1088:
1016:
873:degradation
746:itraconazole
715:of the eye.
704:anti-obesity
701:
693:
629:
617:
605:
585:
565:
548:Soy products
541:angiogenesis
530:
504:
498:
492:
488:
482:
295:calreticulin
177:
161:
140:
91:
56:
36:angiogenesis
31:
29:
3368:thalidomide
3353:tasquinimod
3283:bevacizumab
3278:angiostatin
3181:prothrombin
3161:osteopontin
3091:angiostatin
3022:- from the
2341:(1): 1–10.
2323:6 May 2009.
1700:January 25,
1123:deformities
1118:Thalidomide
1112:Thalidomide
1085:Bevacizumab
1080:downstream.
1024:ranibizumab
1012:tasquinimod
999:ramucirumab
941:thalidomide
893:angiostatin
735:bevacizumab
697:metastasize
679:Royal Jelly
666:resveratrol
610:mushrooms (
494:Clostridium
491:, such as
441:signalling
433:osteopontin
383:prothrombin
266:angiostatin
152:Bevacizumab
44:exogenously
18:Angiostatic
3424:Categories
3303:endostatin
3263:inhibitors
3212:vasostatin
3106:endostatin
3078:Endogenous
2812:(1): 1–6.
2787:2014-04-15
1548:2024-04-02
1430:2022-07-13
1300:2022-05-09
1198:References
1127:phocomelia
1067:(Afinitor)
1065:everolimus
1057:(Votrient)
980:inhibitors
903:endostatin
789:fumagillin
729:Mechanism
726:Inhibitors
576:ergosterol
537:metastasis
511:endostatin
506:Salmonella
291:vasostatin
281:endostatin
193:Mechanism
190:Inhibitors
144:antibodies
125:, such as
103:angiogenin
40:endogenous
3435:Angiology
3358:tecogalan
3338:prolactin
3242:Exogenous
3171:prolactin
3096:canstatin
2895:: S50–3.
1507:1083-7159
1147:marijuana
1104:in 2004,
1055:pazopanib
1045:sunitinib
1036:(Nexavar)
1034:sorafenib
961:prolactin
922:tecogalan
799:activate
750:inhibits
737:(Avastin)
711:into the
652:Liquorice
646:catechins
642:Green tea
636:glycation
588:) extract
560:genistein
515:chemokine
453:proteases
451:inhibits
402:prolactin
273:apoptosis
127:integrins
99:paracrine
63:malignant
3397:See also
3323:linomide
3193:fragment
2958:19773379
2909:22682133
2863:15313899
2828:21507989
2766:17021318
2718:21717904
2706:Oncology
2676:34446297
2631:20176935
2572:21896639
2523:17432820
2488:23642783
2453:22258895
2412:18955252
2355:20564543
2314:Archived
2286:16217757
2250:18827365
2209:18362935
2160:19053855
2089:17106715
2080:11030720
2040:12168863
2013:15781230
1978:15884816
1943:11340091
1894:15471563
1885:11159378
1843:16969510
1805:151-157.
1742:10625665
1675:15899784
1629:17317817
1588:15961063
1525:20688807
1468:11312106
1388:10605205
1380:15563312
1336:15947805
1294:Archived
1239:19360048
1185:See also
1158:Bleeding
1047:(Sutent)
989:linomide
869:inhibit
719:Overview
662:Red wine
600:TGF-beta
550:such as
513:or IP10
439:integrin
437:inhibit
393:fragment
245:inhibit
198:soluble
46:through
3383:TNP-470
3348:suramin
3273:heparin
3012:- from
3002:- from
2949:2756980
2871:1357974
2622:2842052
2599:Bibcode
2563:3206167
2403:2781774
2294:6846032
2200:2361714
2124:7606203
1902:7243576
1783:2963825
1516:3228024
1106:Avastin
1017:Unknown
865:heparin
838:suramin
785:TNP-470
619:Maitake
489:in vivo
340:ADAMTS8
336:ADAMTS1
215:-B and
200:VEGFR-1
3343:SU5416
3156:Meth-2
3151:Meth-1
3146:maspin
3126:CXCL10
3035:(MeSH)
2956:
2946:
2907:
2869:
2861:
2826:
2764:
2716:
2674:
2629:
2619:
2570:
2560:
2521:
2486:
2451:
2410:
2400:
2363:968172
2361:
2353:
2292:
2284:
2248:
2207:
2197:
2158:
2122:
2097:161680
2095:
2087:
2077:
2038:
2011:
1976:
1941:
1900:
1892:
1882:
1841:
1781:
1740:
1673:
1627:
1586:
1523:
1513:
1505:
1466:
1421:
1386:
1378:
1334:
1237:
1217:Nature
845:SU5416
556:tempeh
461:COL4A2
447:maspin
361:CXCL10
171:, and
70:cancer
66:tumors
3313:IL-12
3308:IFN-α
3298:CM101
3227:NRP-1
3197:SPARC
3141:IL-18
3136:IL-12
3121:IFN-γ
3116:IFN-β
3111:IFN-α
2867:S2CID
2723:9 May
2359:S2CID
2290:S2CID
2093:S2CID
1898:S2CID
1384:S2CID
1359:APMIS
1091:VEGFR
1028:VEGF
965:VEGF
818:IL-12
808:IFN-α
796:CM101
764:lumen
752:VEGFR
740:VEGF
690:Drugs
421:SPARC
406:VEGF
389:-2),
349:IFN-α
241:TSP-2
237:TSP-1
204:NRP-1
115:TGF-β
95:tumor
3232:CDAI
3217:VEGI
3207:TIMP
3131:IL-4
2994:and
2954:PMID
2905:PMID
2859:PMID
2824:PMID
2762:PMID
2725:2022
2714:PMID
2672:PMID
2627:PMID
2568:PMID
2519:PMID
2484:PMID
2449:PMID
2408:PMID
2351:PMID
2282:PMID
2246:PMID
2205:PMID
2156:PMID
2120:PMID
2085:PMID
2036:PMID
2009:PMID
1974:PMID
1939:PMID
1890:PMID
1839:PMID
1779:PMID
1738:PMID
1702:2012
1671:PMID
1625:PMID
1584:PMID
1521:PMID
1503:ISSN
1464:PMID
1419:ISBN
1376:PMID
1332:PMID
1235:PMID
760:mTOR
624:VEGF
598:and
596:VEGF
574:and
554:and
552:tofu
527:Diet
503:and
426:VEGF
412:VEGI
371:and
365:IL-4
355:and
338:and
326:CDAI
324:and
322:TIMP
315:VEGF
313:and
311:bFGF
239:and
217:PIGF
213:VEGF
211:for
202:and
107:VEGF
52:diet
3187:-2)
2944:PMC
2936:doi
2897:doi
2893:129
2851:doi
2814:doi
2810:122
2752:doi
2748:355
2662:hdl
2654:doi
2617:PMC
2607:doi
2595:107
2558:PMC
2550:doi
2511:doi
2476:doi
2472:120
2439:doi
2398:PMC
2390:doi
2343:doi
2274:doi
2270:118
2236:doi
2195:PMC
2187:doi
2148:doi
2075:PMC
2067:doi
2001:doi
1997:330
1966:doi
1929:doi
1925:131
1880:PMC
1870:doi
1829:doi
1769:doi
1765:263
1728:doi
1724:275
1661:doi
1615:doi
1576:doi
1572:333
1511:PMC
1495:doi
1456:doi
1411:doi
1368:doi
1364:112
1324:doi
1225:doi
1221:458
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369:-12
111:FGF
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