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Angiopoietin-like protein 2 maintains tissue homeostasis by promoting adaptive inflammation and subsequent tissue reconstruction, whereas an excess of ANGPTL2 activation induced by prolonged stress promotes the breakdown of tissue homeostasis due to chronic inflammation, promoting the development of
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1154:"Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting"
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metabolic diseases. ANGPTL2 has a role also in angiogenesis, in tissue repair, in obesity, in atherosclerotic diseases and finally in carcinogenesis.
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Sun H, Zheng JM, Chen S, et al. (2007). "Enhanced expression of ANGPTL2 in the microvascular lesions of diabetic glomerulopathy".
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296:
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Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction".
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with homology to the angiopoietins and may exert a function on endothelial cells through
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family and the only known growth factors largely specific for the vascular endothelium.
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1038:
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1313:"Identification of a novel human angiopoietin-like gene expressed mainly in heart"
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National Center for
Biotechnology Information, U.S. National Library of Medicine
1121:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1210:
Kadomatsu, Tsuyoshi; Endo, Motoyoshi; Miyata, Keishi; Oike, Yuichi (May 2014).
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participate in the formation of blood vessels. ANGPTL2 protein is a secreted
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Kim I, Moon SO, Koh KN, Kim H, Uhm CS, Kwak HJ, Kim NG, Koh GY (Oct 1999).
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1212:"Diverse roles of ANGPTL2 in physiology and pathophysiology"
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Humphray SJ, Oliver K, Hunt AR, et al. (2004).
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may be too technical for most readers to understand
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1348:"DNA sequence and analysis of human chromosome 9"
319:
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16:Protein-coding gene in the species Homo sapiens
1100:GRCm38: Ensembl release 89: ENSMUSG00000004105
1483:
8:
1311:Zeng L, Dai J, Ying K, et al. (2003).
1079:GRCh38: Ensembl release 89: ENSG00000136859
1490:
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1197:"Entrez Gene: ANGPTL2 angiopoietin-like 2"
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1010:that in humans is encoded by the ANGPTL2
62:Learn how and when to remove this message
46:, without removing the technical details.
1216:Trends in Endocrinology & Metabolism
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640:collagen-containing extracellular matrix
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44:make it understandable to non-experts
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1462:. You can help Knowledge (XXG) by
1031:vascular endothelial growth factor
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656:multicellular organism development
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488:choroid plexus of fourth ventricle
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103:, ARP2, HARP, angiopoietin like 2
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492:extensor digitorum longus muscle
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1000:Angiopoietin-related protein 2
571:More reference expression data
526:More reference expression data
1:
1514:Human chromosome 9 gene stubs
293:
192:
1509:Genes on human chromosome 9
1004:angiopoietin-like protein 2
446:stromal cell of endometrium
442:subcutaneous adipose tissue
1530:
1437:
1266:gene details page in the
604:signaling receptor binding
1229:10.1016/j.tem.2014.03.012
1135:"Mouse PubMed Reference:"
1117:"Human PubMed Reference:"
986:
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954:
941:Chr 9: 127.09 – 127.12 Mb
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1171:10.1074/jbc.274.37.26523
414:tendon of biceps brachii
948:Chr 2: 33.11 – 33.14 Mb
1296:10.1006/abio.1996.0138
1330:10.1007/s100380300025
630:extracellular exosome
1399:Nephron Exp. Nephrol
1260:genome location and
625:extracellular region
287:Chromosome 2 (mouse)
185:Chromosome 9 (human)
1372:10.1038/nature02465
1364:2004Natur.429..369H
1268:UCSC Genome Browser
1029:are members of the
635:extracellular space
149:ANGPTL2 - orthologs
1450:This article on a
786:ENSMUSG00000004105
649:Biological process
618:Cellular component
597:Molecular function
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1275:Further reading
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988:View/Edit Mouse
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767:ENSG00000136859
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1405:(4): e117–23.
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1035:Angiopoietin-1
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1317:J. Hum. Genet
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842:RefSeq (mRNA)
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591:Gene ontology
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32:This article
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21:
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1464:expanding it
1456:chromosome 9
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1047:glycoprotein
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246:127,122,635
233:127,087,348
108:External IDs
58:
49:
33:
1158:J Biol Chem
430:gallbladder
347:33,137,729
334:33,106,081
86:Identifiers
1503:Categories
1106:, May 2017
1085:, May 2017
1061:References
496:belly cord
392:(ortholog)
326:2|2 B
129:HomoloGene
52:April 2013
1454:on human
1055:paracrine
1051:autocrine
924:NP_036053
903:NP_036230
877:NM_011923
856:NM_012098
686:Orthologs
137:GeneCards
1427:30326676
1419:17347581
1390:15164053
1339:12624729
1238:24746520
1180:10473614
1102:–
1081:–
1057:action.
1018:Function
972:Wikidata
665:Sources:
1381:2734081
1360:Bibcode
1304:8619474
1263:ANGPTL2
1257:ANGPTL2
1104:Ensembl
1083:Ensembl
1008:protein
798:UniProt
753:Ensembl
692:Species
671:QuickGO
367:pattern
141:ANGPTL2
125:1347002
100:ANGPTL2
93:Aliases
77:ANGPTL2
38:Please
1425:
1417:
1388:
1378:
1352:Nature
1337:
1302:
1254:Human
1236:
1178:
1041:, and
958:search
956:PubMed
831:Q9R045
812:Q9UKU9
708:Entrez
538:BioGPS
438:glutes
225:9q33.3
117:605001
1458:is a
1423:S2CID
1006:is a
741:26360
722:23452
701:Mouse
696:Human
667:Amigo
476:ankle
426:tibia
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
162:Human
133:22695
1460:stub
1452:gene
1415:PMID
1386:PMID
1335:PMID
1300:PMID
1234:PMID
1176:PMID
1012:gene
373:Bgee
321:Band
282:Chr.
220:Band
179:Chr.
113:OMIM
1407:doi
1403:105
1376:PMC
1368:doi
1356:429
1325:doi
1292:doi
1288:236
1224:doi
1166:doi
1162:274
1053:or
508:lip
343:End
242:End
145:OMA
121:MGI
42:to
1505::
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1188:^
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1137:.
1119:.
1090:^
1069:^
1037:,
1014:.
669:/
349:bp
336:bp
248:bp
235:bp
143:;
139::
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1491:e
1484:t
1477:v
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59:(
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50:(
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
