203:
36:
1794:
543:
Bezisterim, a derivative of the natural anti-inflammatory steroid β-AET, is an orally active NF-κB inhibitor. It has been shown to protect neurons by reducing inflammation and improving glucose utilization, thereby promoting brain health. Clinical results have demonstrated that bezisterim can improve
270:
428:
Ahlem, Clarence N.; Auci, Dominick L.; Nicoletti, Ferdinando; Pieters, Raymond; Kennedy, Michael R.; Page, Theodore M.; Reading, Christopher L.; Enioutina, Elena Y.; Frincke, James M. (2011).
483:
Dillon, Joseph S. (2005). "Dehydroepiandrosterone, Dehydroepiandrosterone
Sulfate and Related Steroids: Their Role in Inflammatory, Allergic and Immunological Disorders".
284:
312:
InChI=1S/C19H30O3/c1-18-7-5-12(20)9-11(18)10-15(21)17-13-3-4-16(22)19(13,2)8-6-14(17)18/h10,12-17,20-22H,3-9H2,1-2H3/t12-,13-,14-,15-,16-,17-,18-,19-/m0/s1
674:
1036:
1835:
1357:
900:
304:
1312:
1056:
1031:
716:
64:
591:"Molecular Targets for 17α-Ethynyl-5-Androstene-3β,7β,17β-Triol, an Anti-Inflammatory Agent Derived from the Human Metabolome"
1663:
1297:
1006:
667:
1608:
1026:
971:
430:"Pharmacology and immune modulating properties of 5-androstene-3β,7β,17β-triol, a DHEA metabolite in the human metabolome"
1648:
1643:
966:
162:
750:
1126:
182:
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1111:
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730:
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910:
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359:
1821:
1558:
1347:
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694:
383:
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1076:
1071:
852:
1854:
1733:
1618:
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1277:
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1141:
1101:
1081:
1061:
1051:
602:
198:
1773:
1493:
1400:
1382:
1372:
1342:
1011:
996:
961:
797:
405:
117:
1396:
1392:
1322:
1232:
1217:
1202:
1131:
465:
391:
1638:
1633:
1307:
1686:
1681:
1623:
1362:
1282:
1192:
867:
807:
638:
620:
558:"Rationale for an anti-inflammatory insulin sensitizer in a phase 3 Alzheimer's disease trial"
500:
457:
449:
394:
379:
375:
544:
cognition and biomarker levels in AD patients and is currently in phase III clinical trials .
1548:
1464:
1337:
1332:
1327:
1287:
1252:
1237:
1227:
1222:
1212:
1207:
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792:
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219:
202:
171:
1864:
1748:
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1668:
1578:
1573:
1387:
1377:
1121:
1021:
1016:
986:
126:
520:"Approved drugs and natural products at clinical stages for treating Alzheimer's disease"
606:
1805:
1711:
1691:
1553:
1257:
981:
920:
812:
769:
760:
633:
590:
518:
Ma, Yajing; Liu, Sufang; Zhou, Qingfeng; Li, Zhonghua; Zhang, Zhijian; Yu, Bin (2024).
363:
351:
20:
538:
1848:
1479:
976:
402:
151:
1706:
1701:
1653:
1598:
1588:
1583:
1469:
1419:
1041:
991:
842:
837:
725:
469:
615:
589:
Reading, Christopher L.; Frincke, James M.; White, Steven K. (24 February 2012).
1738:
1628:
1513:
1411:
1302:
939:
915:
702:
445:
27:
1743:
1187:
683:
556:
Reading, Chris L; Ahlem, Clarence N; Parameswaran, Narayanan (December 2021).
398:
355:
246:
35:
624:
496:
453:
1728:
1676:
1167:
822:
642:
504:
461:
1162:
1151:
948:
925:
817:
371:
367:
1793:
1801:
1177:
1172:
686:
574:
557:
347:
137:
652:
881:
11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone)
269:
260:
656:
187:
104:)-10,13-Dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1
51:
AET; Androst-5-ene-3β,7β,17β-triol; β-Androstenetriol; β-AET
362:(DHEA). It is believed to have similar effects as DHEA and
434:
The
Journal of Steroid Biochemistry and Molecular Biology
366:. A study in rodents found that the compound was a weak
1809:
1720:
1492:
1410:
1150:
947:
938:
866:
768:
759:
693:
258:
245:
218:
213:
181:
161:
136:
116:
55:
47:
42:
896:11β-Hydroxyprogesterone (21-deoxycorticosterone)
150:
125:
1198:16β,17α-Epiestriol (16β-hydroxy-17α-estradiol)
485:Current Drug Targets. Inflammation and Allergy
1829:
668:
8:
26:
408:) have been developed and are under study.
1836:
1822:
1193:17α-Epiestriol (16α-hydroxy-17α-estradiol)
944:
765:
675:
661:
653:
201:
34:
632:
614:
573:
170:
423:
421:
417:
309:
289:
197:
69:
977:Adrenosterone (11-ketoandrostenedione)
25:
1188:16β-Epiestriol (16β-hydroxyestradiol)
7:
1790:
1788:
527:Chinese Journal of Natural Medicines
108:-cyclopentaphenanthrene-3,7,17-triol
1358:Estradiol 3-glucuronide 17β-sulfate
141:
14:
901:18-Hydroxy-11-deoxycorticosterone
751:11β,17α,21-Trihydroxypregnenolone
1792:
230:
1107:Dihydrotestosterone glucuronide
317:Key:OEVZKEVBDIDVOI-YSZCXEEOSA-N
292:C12CC3(1CC2O)(C=C43(CC(C4)O)C)O
778:3α,5α-Tetrahydrocorticosterone
236:
224:
1:
1057:3α-Androstanediol glucuronide
539:10.1016/S1875-5364(24)60606-0
336:androst-5-ene-3β,7β,17β-triol
1808:. You can help Knowledge by
746:17α,21-Dihydroxypregnenolone
616:10.1371/journal.pone.0032147
1127:Etiocholanolone glucuronide
1112:Dihydrotestosterone sulfate
446:10.1016/j.jsbmb.2011.04.010
397:of androstenetriol such as
1886:
1787:
1027:16α-Hydroxyandrostenedione
972:11β-Hydroxyandrostenedione
957:11-Ketodihydrotestosterone
562:Alzheimer's & Dementia
374:, but did not bind to the
214:Chemical and physical data
18:
1649:7β-Hydroxyepiandrosterone
1644:7α-Hydroxyepiandrosterone
967:7β-Hydroxyepiandrosterone
401:(HE3286, NE3107; the 17α-
300:
280:
60:
33:
1534:5α-Dihydrocorticosterone
1475:Pregnanediol glucuronide
1137:Testosterone glucuronide
1097:Androsterone glucuronide
1037:16α-Hydroxy-DHEA sulfate
906:18-Hydroxycorticosterone
858:3α,5α-Tetrahydrocortisol
783:5α-Dihydrocorticosterone
497:10.2174/1568010054022079
388:glucocorticoid receptors
19:Not to be confused with
1769:11β-Hydroxyprogesterone
1764:11α-Hydroxyprogesterone
1440:20β-Dihydroprogesterone
1435:20α-Dihydroprogesterone
1430:17α-Hydroxyprogesterone
1425:16α-Hydroxyprogesterone
1353:Estradiol 3-glucuronide
833:17α-Hydroxyprogesterone
828:17α-Hydroxypregnenolone
736:17α-Hydroxypregnenolone
731:11β-Hydroxypregnenolone
1569:11-Deoxycorticosterone
1544:5β-Dihydroprogesterone
1539:5α-Dihydroprogesterone
1529:3β-Dihydroprogesterone
1524:3α-Dihydroprogesterone
1450:11-Deoxycorticosterone
1445:5α-Dihydroprogesterone
1087:Androstenediol sulfate
1067:5β-Dihydrotestosterone
911:18-Hydroxyprogesterone
891:11-Deoxycorticosterone
788:11-Deoxycorticosterone
741:21-Hydroxypregnenolone
360:dehydroepiandrosterone
1800:This article about a
1759:7α-Hydroxycholesterol
1739:Calcidiol/Calcifediol
1368:Estradiol 17β-sulfate
1348:Estradiol glucuronide
1268:27-Hydroxycholesterol
876:5α-Dihydroaldosterone
721:-Dihydroxycholesterol
1734:7-Dehydrocholesterol
1594:Pregnenolone sulfate
1142:Testosterone sulfate
1102:Androsterone sulfate
1774:Cholesterol sulfate
1509:-Hydroxycholesterol
1401:estradiol palmitate
1383:Estriol glucuronide
1373:Estrone glucuronide
1343:Estradiol disulfate
1012:Dihydrotestosterone
997:Dehydroandrosterone
962:11-Ketotestosterone
798:11-Ketoprogesterone
712:-Hydroxycholesterol
607:2012PLoSO...732147R
30:
1397:estradiol stearate
1393:Lipoidal estradiol
1323:2-Methoxyestradiol
1248:16β-Hydroxyestrone
1243:16α-Hydroxyestrone
1233:4-Methoxyestradiol
1218:4-Hydroxyestradiol
1203:2-Hydroxyestradiol
1132:Epietiocholanolone
1077:3β-Etiocholanediol
1072:3α-Etiocholanediol
868:Mineralocorticoids
853:5α-Dihydrocortisol
575:10.1002/alz.057438
1860:Human metabolites
1817:
1816:
1782:
1781:
1619:3α-Androstanediol
1488:
1487:
1363:Estradiol sulfate
1283:4-Androstenedione
1278:3β-Androstanediol
1273:3α-Androstanediol
1062:3β-Androstanediol
1052:3α-Androstanediol
934:
933:
808:21-Deoxycortisone
340:β-androstenetriol
325:
324:
271:Interactive image
183:CompTox Dashboard
16:Chemical compound
1877:
1838:
1831:
1824:
1796:
1789:
1549:Allopregnanolone
1465:Allopregnanediol
1338:4-Methoxyestriol
1333:2-Methoxyestriol
1328:2-Methoxyestrone
1313:16α-Hydroxy-DHEA
1288:5-Androstenediol
1253:16-Ketoestradiol
1238:4-Methoxyestrone
1228:4-Hydroxyestrone
1223:4-Hydroxyestriol
1213:2-Hydroxyestrone
1208:2-Hydroxyestriol
1117:Etiocholanedione
1082:Androstanetriols
1032:16α-Hydroxy-DHEA
945:
886:11-Deoxycortisol
803:21-Deoxycortisol
793:11-Deoxycortisol
766:
677:
670:
663:
654:
647:
646:
636:
618:
586:
580:
579:
577:
553:
547:
546:
524:
515:
509:
508:
480:
474:
473:
425:
350:produced in the
273:
253:
238:
232:
226:
206:
205:
191:
189:
174:
154:
144:
143:
129:
38:
31:
29:
1885:
1884:
1880:
1879:
1878:
1876:
1875:
1874:
1845:
1844:
1843:
1842:
1785:
1783:
1778:
1749:Cholecalciferol
1716:
1697:Androstadienone
1669:Etiocholanolone
1639:7β-Hydroxy-DHEA
1634:7α-Hydroxy-DHEA
1579:Isopregnanolone
1574:Epipregnanolone
1484:
1406:
1388:Estriol sulfate
1378:Estrone sulfate
1308:7α-Hydroxy-DHEA
1146:
1122:Etiocholanolone
1092:Androstenetriol
1022:Epitestosterone
1017:Epiandrosterone
987:Androstenedione
930:
862:
770:Glucocorticoids
761:Corticosteroids
755:
689:
681:
651:
650:
588:
587:
583:
555:
554:
550:
522:
517:
516:
512:
482:
481:
477:
427:
426:
419:
414:
328:Androstenetriol
321:
318:
313:
308:
307:
296:
293:
288:
287:
276:
251:
241:
235:
229:
209:
199:DTXSID201043225
185:
177:
157:
140:
132:
112:
109:
68:
67:
28:Androstenetriol
24:
17:
12:
11:
5:
1883:
1881:
1873:
1872:
1867:
1862:
1857:
1847:
1846:
1841:
1840:
1833:
1826:
1818:
1815:
1814:
1797:
1780:
1779:
1777:
1776:
1771:
1766:
1761:
1752:
1751:
1746:
1741:
1736:
1724:
1722:
1718:
1717:
1715:
1714:
1712:Estratetraenol
1709:
1704:
1699:
1694:
1692:Androstadienol
1689:
1687:3β-Androstenol
1684:
1682:3α-Androstenol
1672:
1671:
1666:
1661:
1656:
1651:
1646:
1641:
1636:
1631:
1626:
1624:3α-Androstenol
1621:
1612:
1611:
1606:
1601:
1596:
1591:
1586:
1581:
1576:
1571:
1566:
1561:
1556:
1554:Corticosterone
1551:
1546:
1541:
1536:
1531:
1526:
1517:
1516:
1511:
1498:
1496:
1490:
1489:
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1390:
1385:
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1365:
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1355:
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1310:
1305:
1300:
1295:
1290:
1285:
1280:
1275:
1270:
1261:
1260:
1258:16-Ketoestrone
1255:
1250:
1245:
1240:
1235:
1230:
1225:
1220:
1215:
1210:
1205:
1200:
1195:
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1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
982:Androstenediol
979:
974:
969:
964:
959:
953:
951:
942:
936:
935:
932:
931:
929:
928:
923:
921:Corticosterone
918:
913:
908:
903:
898:
893:
888:
883:
878:
872:
870:
864:
863:
861:
860:
855:
846:
845:
840:
835:
830:
825:
820:
815:
813:Corticosterone
810:
805:
800:
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790:
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780:
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772:
763:
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748:
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690:
682:
680:
679:
672:
665:
657:
649:
648:
581:
548:
533:(8): 699–710.
510:
491:(3): 377–385.
475:
416:
415:
413:
410:
364:androstenediol
352:adrenal glands
323:
322:
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110:
71:
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40:
39:
21:Androstenediol
15:
13:
10:
9:
6:
4:
3:
2:
1882:
1871:
1870:Steroid stubs
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1512:
1510:
1508:
1503:
1500:
1499:
1497:
1495:
1494:Neurosteroids
1491:
1481:
1480:Pregnanetriol
1478:
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1471:
1468:
1466:
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1460:
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1209:
1206:
1204:
1201:
1199:
1196:
1194:
1191:
1189:
1186:
1184:
1183:17α-Estradiol
1181:
1179:
1176:
1174:
1171:
1169:
1166:
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1161:
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1157:
1155:
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1038:
1035:
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601:(2): e32147.
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43:Clinical data
41:
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22:
1810:expanding it
1799:
1784:
1755:
1727:
1707:Androsterone
1702:Androstenone
1675:
1664:DHEA sulfate
1654:Androsterone
1616:Androstanes:
1615:
1599:Progesterone
1589:Pregnenolone
1584:Pregnanolone
1520:
1506:
1502:Cholestanes:
1501:
1470:Pregnanediol
1462:Metabolites:
1461:
1420:Progesterone
1412:Progestogens
1320:Metabolites:
1319:
1298:DHEA sulfate
1264:
1159:
1091:
1049:Metabolites:
1048:
1042:Testosterone
1007:DHEA sulfate
992:Androsterone
940:Sex steroids
850:Metabolites:
849:
843:Progesterone
838:Pregnenolone
726:Pregnenolone
718:
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440:(3): 87–94.
437:
433:
384:progesterone
343:
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327:
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105:
101:
97:
93:
89:
85:
81:
77:
73:
1855:Androstanes
1629:7-Keto-DHEA
1514:Cholesterol
1303:7-Keto-DHEA
916:Aldosterone
703:Cholesterol
403:ethynylated
254: g·mol
56:Identifiers
48:Other names
1849:Categories
1744:Calcitriol
1677:Pheromones
1521:Pregnanes:
695:Precursors
684:Endogenous
412:References
406:derivative
399:bezisterim
356:metabolite
259:3D model (
247:Molar mass
172:Q0CZ537GC8
118:CAS Number
65:IUPAC name
1729:Vitamin D
1168:Estradiol
1160:Estranes:
1152:Estrogens
949:Androgens
823:Cortisone
625:1932-6203
454:0960-0760
395:analogues
392:Synthetic
127:2697-85-0
1455:5α-DHDOC
1163:Estetrol
926:Cortisol
818:Cortisol
687:steroids
643:22384159
595:PLOS ONE
505:16101547
462:21570467
380:estrogen
376:androgen
372:estrogen
368:androgen
1802:steroid
1756:Others:
1395:(e.g.,
1265:Others:
1178:Estriol
1173:Estrone
634:3286445
603:Bibcode
470:5123272
348:steroid
346:) is a
252:306.446
220:Formula
152:9818024
138:PubChem
1865:Triols
1721:Others
717:20α,22
641:
631:
623:
568:(S9).
503:
468:
460:
452:
285:SMILES
1804:is a
1609:THDOC
1564:DHDOC
523:(PDF)
466:S2CID
386:, or
354:as a
344:β-AET
342:, or
305:InChI
261:JSmol
1806:stub
1659:DHEA
1293:DHEA
1002:DHEA
639:PMID
621:ISSN
501:PMID
458:PMID
450:ISSN
370:and
163:UNII
1604:THB
1559:DHC
629:PMC
611:doi
570:doi
535:doi
493:doi
442:doi
438:126
358:of
332:AET
188:EPA
142:CID
100:,17
96:,14
92:,13
88:,10
1851::
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1399:,
708:22
637:.
627:.
619:.
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420:^
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338:,
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234:30
228:19
84:,9
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1837:e
1830:t
1823:v
1812:.
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710:R
676:e
669:t
662:v
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599:7
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572::
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495::
489:4
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330:(
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240:3
237:O
231:H
225:C
190:)
186:(
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102:S
98:S
94:S
90:R
86:S
82:R
78:R
74:S
23:.
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