Knowledge (XXG)

Anemia

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464: 62: 2349:. Iron is an essential part of hemoglobin, and low iron levels result in decreased incorporation of hemoglobin into red blood cells. In the United States, 12% of all women of childbearing age have iron deficiency, compared with only 2% of adult men. The incidence is as high as 20% among African American and Mexican American women. In India it is even more than 50%. Studies have linked iron deficiency without anemia to poor school performance and lower 3006: 1263: 1486:
reticulocyte count can be done manually following special staining of the blood film. In manual examination, activity of the bone marrow can also be gauged qualitatively by subtle changes in the numbers and the morphology of young RBCs by examination under a microscope. Newly formed RBCs are usually slightly larger than older RBCs and show polychromasia. Even where the source of blood loss is obvious, evaluation of
8732: 1553:. In clinical workup, the MCV will be one of the first pieces of information available, so even among clinicians who consider the "kinetic" approach more useful philosophically, morphology will remain an important element of classification and diagnosis. Limitations of MCV include cases where the underlying cause is due to a combination of factors – such as iron deficiency (a cause of microcytosis) and vitamin 1274: 8762: 432: 8772: 672: 8752: 8742: 2630:
recently transfused for iron deficiency would have small, pale, iron deficient red blood cells (RBCs) and the donor RBCs of normal size and color. Similarly, a person transfused for severe folate or vitamin B12 deficiency would have two cell populations, but, in this case, the patient's RBCs would be larger and paler than the donor's RBCs.
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undergoing non-cardiac surgery demonstrated that patients were much less likely to require red cell transfusion and in those transfused, the volumes were unchanged (mean difference -0.09, 95% CI -0.23 to 0.05). Pre-operative hemoglobin concentration was increased in those receiving 'high dose' EPO, but not 'low dose'.
2810:. Daily iron supplements have been shown to be effective in reducing anemia in women of childbearing age. When taking iron supplements, stomach upset or darkening of the feces are commonly experienced. The stomach upset can be alleviated by taking the iron with food; however, this decreases the amount of iron absorbed. 2767:, and pernicious anemia, the most important of them being deficiency and sickle cell anemia with together 60% of market share because of highest prevalence as well as higher treatment costs compared with other types. Treatment for anemia depends on cause and severity. Vitamin supplements given orally ( 2534:
anemias often present with neutrophil hypersegmentation (six to 10 lobes). The nonmegaloblastic macrocytic anemias have different etiologies (i.e. unimpaired DNA globin synthesis,) which occur, for example, in alcoholism. In addition to the nonspecific symptoms of anemia, specific features of vitamin B
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Symptoms of anemia can come on quickly or slowly. Early on there may be few or no symptoms. If the anemia continues slowly (chronic), the body may adapt and compensate for this change. In this case, no symptoms may appear until the anemia becomes more severe. Symptoms can include feeling tired, weak,
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Anemia affects 27% of the world's population with iron-deficiency anemia accounting for more than 60% of it. A moderate degree of iron-deficiency anemia affected approximately 610 million people worldwide or 8.8% of the population. It is somewhat more common in females (9.9%) than males (7.8%).
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The "kinetic" approach to anemia yields arguably the most clinically relevant classification of anemia. This classification depends on evaluation of several hematological parameters, particularly the blood reticulocyte (precursor of mature RBCs) count. This then yields the classification of defects
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are often used instead to indirectly estimate the value. Hematocrit; however, is concentration dependent and is therefore not completely accurate. For example, during pregnancy a woman's RBC mass is normal but because of an increase in blood volume the hemoglobin and hematocrit are diluted and thus
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preparations can be used. Parenteral iron can improve iron stores rapidly and is also effective for treating people with postpartum haemorrhage, inflammatory bowel disease, and chronic heart failure. The body can absorb up to 6 mg iron daily from the gastrointestinal tract. In many cases, the
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Macrocytic anemia can be further divided into "megaloblastic anemia" or "nonmegaloblastic macrocytic anemia". The cause of megaloblastic anemia is primarily a failure of DNA synthesis with preserved RNA synthesis, which results in restricted cell division of the progenitor cells. The megaloblastic
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Catassi C, Bai JC, Bonaz B, Bouma G, CalabrĂČ A, Carroccio A, Castillejo G, Ciacci C, Cristofori F, Dolinsek J, Francavilla R, Elli L, Green P, Holtmeier W, Koehler P, Koletzko S, Meinhold C, Sanders D, Schumann M, Schuppan D, Ullrich R, VĂ©csei A, Volta U, Zevallos V, Sapone A, Fasano A (September
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Apart from that, iron supplements, antibiotics, immunosuppressant, bone marrow stimulants, corticosteroids, gene therapy and iron chelating agents are forms of anemia treatment drugs, with immunosuppressants and corticosteroids accounting for 58% of the market share. A paradigm shift towards gene
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A person with sideroblastic anemia (a defect in heme synthesis, commonly caused by alcoholism, but also drugs/toxins, nutritional deficiencies, a few acquired and rare congenital diseases) can have a dimorphic smear from the sideroblastic anemia alone. Evidence for multiple causes appears with an
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A 2012 review concluded that when considering blood transfusions for anaemia in people with advanced cancer who have fatigue and breathlessness (not related to cancer treatment or haemorrhage), consideration should be given to whether there are alternative strategies can be tried before a blood
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A blood test will provide counts of white blood cells, red blood cells and platelets. If anemia appears, further tests may determine what type it is, and whether it has a serious cause. although of that, it is possible to refer to the genetic history and physical diagnosis. These tests may also
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unless hemoglobin levels are less than 10 g/dL or they have symptoms of anemia. Their use should be along with parenteral iron. The 2020 Cochrane Anaesthesia Review Group review of erythropoietin (EPO) plus iron versus control treatment including placebo or iron for preoperative anaemic adults
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Nutritional iron deficiency is common in developing nations. An estimated two-thirds of children and of women of childbearing age in most developing nations are estimated to have iron deficiency without anemia with one-third of them having an iron deficiency with anemia. Iron deficiency due to
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A dimorphic appearance on a peripheral blood smear occurs when there are two simultaneous populations of red blood cells, typically of different size and hemoglobin content (this last feature affecting the color of the red blood cell on a stained peripheral blood smear). For example, a person
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An estimated 30% of adults who require non-cardiac surgery have anemia. In order to determine an appropriate preoperative treatment, it is suggested that the cause of anemia be first determined. There is moderate level medical evidence that supports a combination of iron supplementation and
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supplementation. The injections are quick-acting, and symptoms usually go away within one to two weeks. As the condition improves, doses are reduced to weeks and then can be given monthly. Intramuscular therapy leads to more rapid improvement and should be considered in patients with severe
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is a calculation of the ratio between the level of anemia and the extent to which the reticulocyte count has risen in response. If the degree of anemia is significant, even a "normal" reticulocyte count actually may reflect an inadequate response. If an automated count is not available, a
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In 2013, anemia due to iron deficiency resulted in about 183,000 deaths – down from 213,000 deaths in 1990. This condition is most prevalent in children with also an above average prevalence in elderly and women of reproductive age (especially during pregnancy). Anemia is one of the six
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Reticulocyte counts, and the "kinetic" approach to anemia, have become more common than in the past in the large medical centers of the United States and some other wealthy nations, in part because some automatic counters now have the capacity to include reticulocyte counts. A
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who are not actively bleeding transfusions are only recommended when the hemoglobin is below 70 to 80g/L (7 to 8 g/dL). Transfusing earlier does not improve survival. Transfusions otherwise should only be undertaken in cases of cardiovascular instability.
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is typically based on a person's signs and symptoms. In those without symptoms, they are not recommended unless hemoglobin levels are less than 60 to 80 g/L (6 to 8 g/dL). These recommendations may also apply to some people with acute bleeding.
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Confirm by repeating reticulocyte count: ongoing combination of low reticulocyte production index, normal MCV and hemolysis or loss may be seen in bone marrow failure or anemia of chronic disease, with superimposed or related hemolysis or blood
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in teenage girls, although this may be due to socioeconomic factors. Iron deficiency is the most prevalent deficiency state on a worldwide basis. It is sometimes the cause of abnormal fissuring of the angular (corner) sections of the lips
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A person with anemia may not have any symptoms, depending on the underlying cause, and no symptoms may be noticed, as the anemia is initially mild, and then the symptoms become worse as the anemia worsens. A patient with anemia may report
376:. The diagnosis of anemia in men is based on a hemoglobin of less than 130 to 140 g/L (13 to 14 g/dL); in women, it is less than 120 to 130 g/L (12 to 13 g/dL). Further testing is then required to determine the cause. 2754:
The global market for anemia treatments is estimated at more than USD 23 billion per year and is fast growing because of the rising prevalence and awareness of anemia. The types of anemia treated with drugs are iron-deficiency anemia,
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decreased. Another example would be bleeding where the RBC mass would decrease but the concentrations of hemoglobin and hematocrit initially remains normal until fluids shift from other areas of the body to the intravascular space.
683:). Several of these may interplay to cause anemia. The most common cause of anemia is blood loss, but this usually does not cause any lasting symptoms unless a relatively impaired RBC production develops, in turn, most commonly by 3828:"Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995–2011: a systematic analysis of population-representative data" 2993:
Mild iron-deficiency anemia affects another 375 million. Severe anaemia is prevalent globally, and especially in sub-Saharan Africa where it is associated with infections including malaria and invasive bacterial infections.
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inadequate dietary iron intake is rare in men and postmenopausal women. The diagnosis of iron deficiency mandates a search for potential sources of blood loss, such as gastrointestinal bleeding from ulcers or colon cancer.
2926:(ESA) is to maintain hemoglobin at the lowest level that both minimizes transfusions and meets the individual person's needs. They should not be used for mild or moderate anemia. They are not recommended in people with 3338:
Bhutta ZA, Das JK, Rizvi A, Gaffey MF, Walker N, Horton S, Webb P, Lartey A, Black RE (August 2013). "Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost?".
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to meet the body's needs. Infants, toddlers, and pregnant women have higher than average needs. Increased iron intake is also needed to offset blood losses due to digestive tract issues, frequent blood donations, or
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Certain gastrointestinal disorders can cause anemia. The mechanisms involved are multifactorial and not limited to malabsorption but mainly related to chronic intestinal inflammation, which causes dysregulation of
2558:, who bled dogs to make them anemic, and then fed them various substances to see what (if anything) would make them healthy again. He discovered that ingesting large amounts of liver seemed to cure the disease. 3476: 1532:
In the morphological approach, anemia is classified by the size of red blood cells; this is either done automatically or on microscopic examination of a peripheral blood smear. The size is reflected in the
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Iron-deficiency anemia is the most common type of anemia overall and it has many causes. RBCs often appear hypochromic (paler than usual) and microcytic (smaller than usual) when viewed with a microscope.
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The anemia is also classified by severity into mild (110 g/L to normal), moderate (80 g/L to 110 g/L), and severe anemia (less than 80 g/L) in adults. Different values are used in pregnancy and children.
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Qaseem A, Humphrey LL, Fitterman N, Starkey M, Shekelle P (December 2013). "Treatment of anemia in patients with heart disease: a clinical practice guideline from the American College of Physicians".
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Sezer S, Ozdemir FN, Yakupoglu U, Arat Z, Turan M, Haberal M (April 2002). "Intravenous ascorbic acid administration for erythropoietin-hyporesponsive anemia in iron loaded hemodialysis patients".
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allows direct examination of the precursors to red cells, although is rarely used as is painful, invasive and is hence reserved for cases where severe pathology needs to be determined or excluded.
3138:"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015" 655:. Chronic anemia may result in behavioral disturbances in children as a direct result of impaired neurological development in infants, and reduced academic performance in children of school age. 1290:
provide comparison and contrast of them. A strict but broad definition is an absolute decrease in red blood cell mass, however, a broader definition is a lowered ability of the blood to carry
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Whitehead NS, Williams LO, Meleth S, Kennedy SM, Ubaka-Blackmoore N, Geaghan SM, Nichols JH, Carroll P, McEvoy MT, Gayken J, Ernst DJ, Litwin C, Epner P, Taylor J, Graber ML (December 2019).
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suggesting cell destruction; or clinical signs of bleeding, such as guaiac-positive stool, radiographic findings, or frank bleeding. The following is a simplified schematic of this approach:
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from blood that either is too scarce (e.g., blood loss) or is dysfunctional in its oxygen-supplying ability (due to whatever type of hemoglobin or erythrocyte problem). In contrast, the word
3562:"Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013" 5621:
Halterman JS, Kaczorowski JM, Aligne CA, Auinger P, Szilagyi PG (June 2001). "Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States".
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form in the cytoplasm of RBCs and appear as small dark dots under the microscope. In animals, Heinz body anemia has many causes. It may be drug-induced, for example in cats and dogs by
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De Franceschi L, Iolascon A, Taher A, Cappellini MD (July 2017). "Clinical management of iron deficiency anemia in adults: Systemic review on advances in diagnosis and treatment".
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Transfusion dependent anemia is a form of anemia where ongoing blood transfusion are required. Most people with myelodysplastic syndrome develop this state at some point in time.
651:, the consumption of non-food items such as ice, paper, wax, grass, hair or dirt, may be a symptom of iron deficiency; although it occurs often in those who have normal levels of 2840:
In cases where oral iron has either proven ineffective, would be too slow (for example, pre-operatively), or where absorption is impeded (for example in cases of inflammation),
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Stijlemans B, Guilliams M, Raes G, Beschin A, Magez S, De Baetselier P (August 2007). "African trypanosomosis: From immune escape and immunopathology to immune intervention".
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Bellotto F, Cati A (March 2006). "Anemia ed ischemia miocardica: relazioni ed interferenze" [Anemia and myocardial ischemia: relationships and interferences].
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symptoms. Treatment should begin rapidly for severe neurological symptoms, as some changes can become permanent. In some individuals lifelong treatment may be needed.
472: 2718:, is often seen secondary to myelodysplastic syndromes. Iron-deficiency anemia may also be refractory as a manifestation of gastrointestinal problems which disrupt 460:. These symptoms are unspecific and none of the symptoms alone or in combination show a good predictive value for the presence of anemia in non-clinical patients. 4289: 679:
The causes of anemia may be classified as impaired red blood cell (RBC) production, increased RBC destruction (hemolytic anemia), blood loss and fluid overload (
5705: 3513:"Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010" 2412:(mean cell volume divided by the RBC count) predicts whether microcytic anemia may be due to iron deficiency or thalassemia, although it requires confirmation. 2972: 2377:
should be performed to identify bleeding lesions. In older men and women, the chances are higher that bleeding from the gastrointestinal tract could be due to
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Figure shows normal red blood cells flowing freely in a blood vessel. The inset image shows a cross-section of a normal red blood cell with normal hemoglobin.
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Kansagara D, Dyer E, Englander H, Fu R, Freeman M, Kagen D (December 2013). "Treatment of anemia in patients with heart disease: a systematic review".
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Blood transfusions in those without symptoms is not recommended until the hemoglobin is below 60 to 80 g/L (6 to 8 g/dL). In those with
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General causes of hypervolemia include excessive sodium or fluid intake, sodium or water retention and fluid shift into the intravascular space.
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is a severe type of anemia resulting from the replacement of bone marrow by other materials, such as malignant tumors, fibrosis, or granulomas.
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Mody RJ, Brown PI, Wechsler DS (February 2003). "Refractory iron deficiency anemia as the primary clinical manifestation of celiac disease".
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erythropoietin treatment to help reduce the requirement for red blood cell transfusions after surgery in those who have preoperative anemia.
2574: 7007:"Erythropoietin plus iron versus control treatment including placebo or iron for preoperative anaemic adults undergoing non-cardiac surgery" 6833:"Erythropoietin plus iron versus control treatment including placebo or iron for preoperative anaemic adults undergoing non-cardiac surgery" 8501: 7603: 286:. Additional symptoms may occur depending on the underlying cause. Anemia can be temporary or long term and can range from mild to severe. 5300: 4521:
Gyorkos TW, Gilbert NL, Larocque R, CasapĂ­a M (April 2011). "Trichuris and hookworm infections associated with anaemia during pregnancy".
2975:) may require they use the HBO method. A 2005 review of the use of HBO in severe anemia found all publications reported positive results. 5984: 5244: 897:
is a hereditary defect that results in defects in the RBC cell membrane, causing the erythrocytes to be sequestered and destroyed by the
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Balarajan Y, Ramakrishnan U, Özaltin E, Shankar AH, Subramanian S (December 2011). "Anaemia in low-income and middle-income countries".
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Other characteristics visible on the peripheral smear may provide valuable clues about a more specific diagnosis; for example, abnormal
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James SP (April 2005). "National Institutes of Health Consensus Development Conference statement on Celiac Disease, June 28–30, 2004".
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patient has a deficit of over 1,000 mg of iron which would require several months to replace. This can be given concurrently with
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elevated RBC distribution width (RDW), indicating a wider-than-normal range of red cell sizes, also seen in common nutritional anemia.
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with resulting balance difficulties from posterior column spinal cord pathology. Other features may include a smooth, red tongue and
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Martin ND, Scantling D (September 2015). "Hospital-Acquired Anemia: A Contemporary Review of Etiologies and Prevention Strategies".
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Microcytic anemia is primarily a result of hemoglobin synthesis failure/insufficiency, which could be caused by several etiologies:
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Aapro MS, Link H (2008). "September 2007 update on EORTC guidelines and anemia management with erythropoiesis-stimulating agents".
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Author: Saimak T. Nabili, MD, MPH. Editor: Melissa Conrad Stöppler, MD. Last Editorial Review: 12/9/2008. Retrieved on 4 April 2009
2894:. Pernicious anemia caused by loss of intrinsic factor cannot be prevented. If there are other, reversible causes of low vitamin B 7798: 2923: 2475:(atrophic gastritis) that produce intrinsic factor or against intrinsic factor itself. These lead to poor absorption of vitamin B 1549:. This scheme quickly exposes some of the most common causes of anemia; for instance, a microcytic anemia is often the result of 1545:; if they are normal size (80–100 fl), normocytic; and if they are larger than normal (over 100 fl), the anemia is classified as 1311: 1013: 1003: 978: 393: 5596: 3675: 3656: 6789: 5533: 8627: 8061: 7731: 7437: 6803: 6785: 1566:
by decreased RBC production versus increased RBC destruction or loss. Clinical signs of loss or destruction include abnormal
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From the 6th week of pregnancy, hormonal changes cause an increase in the mother's blood volume due to an increase in plasma.
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Treatment depends on the specific cause. Certain groups of individuals, such as pregnant women, can benefit from the use of
6959:"A systematic review of the application of hyperbaric oxygen in the treatment of severe anemia: an evidence-based approach" 795:
levels, combined with blood loss from laboratory testing, generally occurs in premature infants at two to six weeks of age.
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can also be helpful, and it is sometimes a necessity in regions of the world where automated analysis is less accessible.
1244: 416: 7056:"British Committee for Standards in Haematology Guidelines on the Identification and Management of Pre-Operative Anaemia" 5810: 3826:
Stevens GA, Finucane MM, De-Regil LM, Paciorek CJ, Flaxman SR, Branca F, Peña-Rosas JP, Bhutta ZA, Ezzati M (July 2013).
3634: 8607: 7682: 6958: 6913: 997: 993: 334: 8251: 7834: 7527: 3719:"Association of Anemia with Clinical Symptoms Commonly Attributed to Anemia - Analysis of Two Population-Based Cohorts" 7708: 7572: 5712: 531:, sweating, increased thirst, and confusion. There may be also additional symptoms depending on the underlying cause. 361: 3265: 534:
In more severe anemia, the body may compensate for the lack of oxygen-carrying capability of the blood by increasing
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is recommended to stimulate RBC production, and if iron deficiency and inflammation are also present, concurrent
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Macrocytic anemia can also be caused by the removal of the functional portion of the stomach, such as during
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A Giemsa-stained blood film from a person with iron-deficiency anemia. This person also had hemoglobin Kenya.
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Kaufner L, von Heymann C, Henkelmann A, Pace NL, Weibel S, Kranke P, Meerpohl JJ, Gill R (August 13, 2020).
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Caito S, Lopes AC, Paoliello MM, Aschner M (2017). "Toxicology of Lead and Its Damage to Mammalian Organs".
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aids in the body's ability to absorb iron, so taking oral iron supplements with orange juice is of benefit.
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Tayles N (September 1996). "Anemia, genetic diseases, and malaria in prehistoric mainland Southeast Asia".
3477:"Anemia Treatment Drugs: 2019 Global Market Study; Analyzed by Type of Anemia, Type of Drug, and Geography" 2361:
In the United States, the most common cause of iron deficiency is bleeding or blood loss, usually from the
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van Hensbroek MB, Jonker F, Bates I (September 2011). "Severe acquired anaemia in Africa: new concepts".
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may be noticed in some cases of iron-deficiency anemia. There may be signs of specific causes of anemia,
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Normocytic anemia occurs when the overall hemoglobin levels are decreased, but the red blood cell size (
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Kotzé A, Harris A, Baker C, Iqbal T, Lavies N, Richards T, Ryan K, Taylor C, Thomas D (November 2015).
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Ng O, Keeler BD, Mishra A, Simpson JA, Neal K, Al-Hassi HO, Brookes MJ, Acheson AG (December 7, 2019).
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is caused by autoimmune attack against red blood cells, primarily by IgG. It is the most common of the
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The hand of a person with severe anemia (on the left, with ring) compared to one without (on the right)
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Anemia is the most common blood disorder, affecting about a fifth to a third of the global population.
3432:"Guidelines on the diagnosis and treatment of iron deficiency across indications: a systematic review" 1700:
shows appropriate response to anemia = ongoing hemolysis or blood loss without RBC production problem.
1354:, which is an important tool in distinguishing between the causes of anemia. Examination of a stained 61: 8695: 8655: 8522: 8336: 8331: 8311: 8246: 8098: 7851: 7846: 7654: 7540: 6375:"Anaemia management in people with chronic kidney disease | Guidance and guidelines | NICE" 5443: 2427: 1339: 1018: 910: 837: 821: 783: 749: 489: 263: 5163:"The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration?" 4895:
Leffler DA, Green PH, Fasano A (October 2015). "Extraintestinal manifestations of coeliac disease".
4566:"Interventions to prevent iatrogenic anemia: a Laboratory Medicine Best Practices systematic review" 2566:
then set about to isolate the curative substance chemically and ultimately were able to isolate the
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For instance, sickle cell anemia with superimposed iron deficiency; chronic gastric bleeding with B
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can help assess whether the bone marrow will be able to compensate for the loss and at what rate.
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WHO's Hemoglobin thresholds used to define anemia (1 g/dL = 0.6206 mmol/L)
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may also result in transfusion dependence. Concerns from repeated blood transfusions include
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Here is a schematic representation of how to consider anemia with MCV as the starting point:
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Fluid overload (hypervolemia) causes decreased hemoglobin concentration and apparent anemia:
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Intrinsic (intracorpuscular) abnormalities cause premature destruction. All of these, except
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is a hereditary disorder or defect featuring aplastic anemia and various other abnormalities.
8796: 8437: 8422: 8299: 8174: 8130: 7633: 7618: 7557: 7247: 7210: 7200: 7153: 7116: 7067: 7026: 7018: 6852: 6844: 6759: 6598: 6590: 6549: 6502: 6462: 6421: 6413: 6348: 6311: 6303: 6262: 6140: 6096: 6088: 6041: 5952: 5911: 5781: 5746: 5677: 5630: 5498: 5353: 5182: 5174: 5133: 5092: 5053: 5016: 5006: 4964: 4954: 4904: 4864: 4854: 4813: 4805: 4714: 4706: 4667: 4624: 4587: 4577: 4530: 4493: 4483: 4430: 4393: 4385: 4051: 3960: 3923: 3884: 3847: 3839: 3740: 3730: 3581: 3573: 3532: 3524: 3443: 3396: 3348: 3157: 3149: 2803: 2799: 2760: 2735: 2617: 2460: 2378: 2244: 1514: 992:, that is, without any known cause, drug-associated or secondary to another disease such as 940: 888: 868: 858: 597: 501: 468: 338: 92: 7276: 6729: 6692: 6075:
Gale RP, Barosi G, Barbui T, Cervantes F, Dohner K, Dupriez B, et al. (January 2011).
6006: 5881:
Hovda L, Brutlag A, Poppenga RH, Peterson K, eds. (2016). "Chapter 69: Onions and garlic".
5772:
Long B, Koyfman A (August 2018). "Emergency Medicine Evaluation and Management of Anemia".
5666:"A review of studies on the effect of iron deficiency on cognitive development in children" 3801: 3036:
Signs of severe anemia in human bones from 4000 years ago have been uncovered in Thailand.
2490:/folate absorption. Therefore, one must always be aware of anemia following this procedure. 8765: 8710: 8571: 8556: 8539: 8479: 8474: 8418: 8396: 8093: 8039: 8019: 7812: 6798: 5814: 5540: 4360: 4207: 3679: 2841: 2829: 2723: 2611: 2523: 2397: 1784:
Clinical findings and abnormal MCV: hemolysis or loss and chronic disorder of production*.
1779:
No clinical findings consistent with hemolysis or blood loss: pure disorder of production.
1184: 1138: 1095: 1006:
is primarily mediated by IgM. It can be idiopathic or result from an underlying condition.
919: 704: 684: 648: 524: 517: 314: 271: 225:
available for oxygen transport, or abnormalities in hemoglobin that impair its function.
202: 6374: 5554: 5210: 4013: 3185: 2905:
deficiency anemia is usually easily treated by providing the necessary level of vitamin B
1198:). Thus ischemia in a body part can cause localized anemic effects within those tissues. 6316: 6291: 5807:
eMedicine – "Vitamin B-12 Associated Neurological Diseases": Article by Niranjan N Singh
5468: 1517:) although the tests will depend on the clinical hypothesis that is being investigated. 671: 8597: 8551: 8364: 8294: 8113: 7829: 7752: 7660: 7457: 7215: 7188: 7031: 7006: 6857: 6832: 6603: 6578: 6426: 6401: 6101: 6076: 5957: 5940: 5915: 5737:
Mentzer WC (April 1973). "Differentiation of iron deficiency from thalassaemia trait".
5597:"Global Iron-Deficiency Anemia Therapy Market – Industry Trends and Forecast to 2027 -" 5187: 5162: 5021: 4994: 4969: 4942: 4869: 4842: 4818: 4793: 4719: 4694: 4592: 4565: 4498: 4471: 4398: 4373: 3852: 3827: 3745: 3718: 3586: 3561: 3537: 3512: 3162: 3137: 2850: 2846: 2821: 2776: 2563: 2495: 2483: 2323: 1554: 1510: 1487: 1351: 1343: 1287: 1262: 1240: 1114: 726: 719: 712: 629: 593: 535: 310: 218: 206: 77: 5883:
Blackwell's Five-Minute Veterinary Consult Clinical Companion: Small Animal Toxicology
5750: 3888: 3843: 3577: 3528: 3352: 3153: 3005: 403:
is the most common cause of anemia worldwide, and affects nearly one billion people.
8790: 8680: 8469: 8464: 8326: 8266: 8169: 7173: 7157: 6352: 6045: 5138: 5121: 4550: 4534: 4230: 3672: 2964: 2798:
Mild to moderate iron-deficiency anemia is treated by oral iron supplementation with
2739: 2646: 2508: 2472: 2446: 2409: 2388:
Worldwide, the most common cause of iron-deficiency anemia is parasitic infestation (
2313: 1106: 1056: 1051: 825: 644: 555: 547: 513: 7336: 7332: 7089: 6522: 6467: 6450: 6145: 6128: 6061: 5650: 4924: 4644: 4073: 3368: 1789:
Clinical findings and normal MCV= acute hemolysis or loss without adequate time for
1273: 1105:
Gastrointestinal tract lesions, causing either acute bleeds (e.g. variceal lesions,
8745: 8685: 8670: 8496: 8221: 8071: 8056: 8002: 7472: 7022: 6848: 6763: 6594: 6417: 6307: 5122:"The aetiology and impact of malnutrition in paediatric inflammatory bowel disease" 3775: 3416: 2825: 2527: 2515: 2504: 2224: 2207: 1474: 1124: 740: 680: 551: 539: 7404: 6626: 6092: 5350:
Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity
431: 411:
global nutrition targets for 2025 and for diet-related global targets endorsed by
246: 'blood'. When anemia comes on slowly, the symptoms are often vague, such as 7347: 5057: 4628: 4488: 4434: 3235: 3210: 8544: 8489: 8386: 8241: 8216: 8034: 7623: 7581: 7410: 7407: 7388: 3314: 2939:
Treatment of exceptional blood loss (anemia) is recognized as an indication for
2756: 2690: 2567: 2431: 2374: 2346: 2297: 2248: 1790: 1498: 1478: 1355: 843: 801: 761: 625: 609: 585: 570: 497: 476: 330: 69: 8632: 5418: 5178: 4843:"Anemia in inflammatory bowel disease: a neglected issue with relevant effects" 4352: 3964: 3642: 2430:, the most common cause of macrocytic anemia, is due to a deficiency of either 8517: 8484: 8256: 8206: 8191: 8186: 8179: 8164: 8154: 7592: 7422: 7121: 7104: 5806: 5785: 5502: 5097: 5080: 4908: 4582: 4389: 2768: 2703: 2649:(paracetamol), or may be caused by eating various plants or other substances: 2642: 2601: 2519: 2500: 2468: 2438: 2340:
Iron-deficiency anemia is due to insufficient dietary intake or absorption of
1917:
and folate deficiency; and other instances of anemia with more than one cause.
1538: 1455: 1359: 1318: 1299: 1110: 1009: 989: 927: 923: 792: 708: 652: 601: 493: 290: 279: 222: 178: 165: 134: 7358: 7000: 6998: 6672: 4995:"Non-Celiac Gluten sensitivity: the new frontier of gluten related disorders" 4959: 4859: 4275: 3692: 8705: 8447: 8442: 8306: 8284: 8159: 8123: 7399: 7364: 7317: 7313: 6554: 6537: 6267: 6250: 5682: 5665: 5634: 5215: 4710: 3928: 3911: 3448: 3431: 2960: 2811: 2547: 2449:. Folate deficiency normally does not produce neurological symptoms, while B 2393: 1195: 1145: 985: 864: 574: 485: 380: 294: 267: 7224: 7165: 7130: 7081: 7040: 6974: 6866: 6771: 6708: 6612: 6563: 6514: 6476: 6435: 6360: 6325: 6154: 6110: 6053: 5793: 5691: 5642: 5570: 5534:
Recommendations to Prevent and Control Iron Deficiency in the United States
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Rhodes CE, Denault D, Varacallo M (2024). "Physiology, Oxygen Transport".
523:
Anemia that develops quickly, often, has more severe symptoms, including,
8211: 7988: 7252:
10.1002/(SICI)1096-8644(199609)101:1<11::AID-AJPA2>3.0.CO;2-G
7205: 2389: 1451: 1224: 1176: 1149: 972: 872: 589: 509: 457: 415:
in 2012 and 2013. Efforts to reach global targets contribute to reaching
387:, without determining the specific cause, is not recommended. The use of 259: 251: 168:, decreased red blood cell production, increased red blood cell breakdown 6726:"Pernicious Anemia Clinical Presentation: History, Physical Examination" 6451:"Clinical use of intravenous iron: administration, efficacy, and safety" 6290:
Low MS, Speedy J, Styles CE, De-Regil LM, Pasricha SR (April 18, 2016).
5469:"Anemia Types, Treatment, Symptoms, Signs, Causes & Iron Deficiency" 3735: 1557:(a cause of macrocytosis) where the net result can be normocytic cells. 8690: 8150: 8118: 8011: 5358: 5081:"Dietary and nutritional considerations for inflammatory bowel disease" 4809: 4746:. Hagerstwon, MD: Lippincott Williams & Wilkins. 2007. p. 62. 2956: 2715: 1128: 1099: 1046: 842:
Leukoerythroblastic anemia is caused by space-occupying lesions in the
723: 637: 449: 346: 302: 247: 146: 7281: 7072: 7055: 5011: 4258:
Pathophysiology : introductory concepts and clinical perspectives
4056: 4039: 1141:, may cause acute or chronic blood loss, especially at advanced stages 17: 7308: 7187:
Abuga KM, Muriuki JM, Williams TN, Atkinson SH (September 22, 2020).
6171:
Blood Banking and Transfusion Medicine: Basic Principles and Practice
4943:"Anemia and iron deficiency in gastrointestinal and liver conditions" 4671: 4038:
Allen RP, Auerbach S, Bahrain H, Auerbach M, Earley CJ (April 2013).
3290:
Smith RE (March 2010). "The clinical and economic burden of anemia".
2951:
delivery to tissue is not sufficient in patients who cannot be given
2948: 2659: 2290: 1502: 1291: 1134: 898: 613: 578: 566: 562: 543: 528: 505: 306: 283: 214: 150: 6168:
Hillyer CD, Silberstein LE, Ness PM, Anderson KC, Roback JD (2006).
4472:"Hookworm-related anaemia among pregnant women: a systematic review" 1493:
When the cause is not obvious, clinicians use other tests, such as:
1120:
Gynecologic disturbances, also generally causing chronic blood loss
7369: 7296: 2686: 2664: 1322: 1272: 1261: 670: 462: 439: 438: 430: 420: 210: 6579:"Blood transfusions for anaemia in patients with advanced cancer" 5553:
Centers for Disease Control Prevention (CDC) (October 11, 2002).
4941:
Stein J, Connor S, Virgin G, Ong DE, Pereyra L (September 2016).
3560:
GBD 2013 Mortality Causes of Death Collaborators (January 2015).
2657:
and dogs after eating either raw or cooked plants from the genus
2675: 2341: 2270: 1307: 1175:
both refer to the basic idea of "lack of blood", but anemia and
282:. Anemia must be significant before a person becomes noticeably 7961: 7426: 6577:
Preston NJ, Hurlow A, Brine J, Bennett MI (February 15, 2012).
5497:. Metal Ions in Life Sciences. Vol. 17. pp. 501–534. 1179:
are not the same thing in modern medical terminology. The word
696:
Disturbance of proliferation and differentiation of stem cells
3104:"Anemia in the emergency department: evaluation and treatment" 3000: 2671: 2654: 1163:, blood loss from repeated blood draws and medical procedures. 408: 104: 6455:
Hematology. American Society of Hematology. Education Program
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Hematology. American Society of Hematology. Education Program
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3717:
Weckmann G, Kiel S, Chenot JF, Angelow A (January 24, 2023).
1071:
alters the surfaces of RBCs of its host and this may explain
813:
Anemia of kidney failure (also causing stem cell dysfunction)
798:
Iron-deficiency anemia, resulting in deficient heme synthesis
577:), but this is not a reliable sign. A blue coloration of the 6924:(4): 205–210. Archived from the original on January 16, 2009 6536:
Goddard AF, James MW, McIntyre AS, Scott BB (October 2011).
2963:
reasons. HBO may be used for medical reasons when threat of
7957: 4693:
Hung SC, Kuo KL, Peng CH, Wu CH, Wang YC, Tarng DC (2015).
4328:
Cotran RS, Kumar V, Fausto N, Robbins SL, Abbas AK (2005).
3430:
Peyrin-Biroulet L, Williet N, Cacoub P (December 1, 2015).
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that leads to decreased access of iron to the circulation.
113: 110: 95: 6914:"Hyperbaric oxygen in exceptional acute blood-loss anemia" 6538:"Guidelines for the management of iron deficiency anaemia" 5885:(2nd ed.). John Wiley & Sons. pp. 515–520. 5858:
Veterinary hematology: a diagnostic guide and color atlas
299:
bleeding due to inflammation of the stomach or intestines
6077:"What are RBC-transfusion-dependence and -independence?" 3186:"Anemia: Practice Essentials, Pathophysiology, Etiology" 2786:
therapy and monoclonal antibody therapies is observed.
2467:
from food. A lack of intrinsic factor may arise from an
538:. The person may have symptoms related to this, such as 452:, weak, decreased ability to concentrate, and sometimes 3017: 2714:
Refractory anemia, an anemia which does not respond to
6548:(10). British Society of Gastroenterology: 1309–1316. 5289:(5 ed.). Elsevier Health Sciences. p. 1085. 2890:
in severe cases or cases of malabsorption of dietary-B
1537:(MCV). If the cells are smaller than normal (under 80 7103:
Kassebaum NJ, GBD 2013 Anemia Collaborators (2016).
6790:"Five Things Physicians and Patients Should Question" 6627:"Pernicious anemia: MedlinePlus Medical Encyclopedia" 5233:(3rd ed.). Philadelphia: Saunders. p. 220. 5120:
Gerasimidis K, McGrogan P, Edwards CA (August 2011).
4372:
Berentsen S, Beiske K, TjĂžnnfjord GE (October 2007).
4307:(8th ed.). Philadelphia: Saunders. p. 432. 2702:
Hyperanemia is a severe form of anemia, in which the
1317:
It is difficult to directly measure RBC mass, so the
791:, by diminished erythropoietin response to declining 293:, decreased red blood cell production, and increased 101: 7286: 6693:"Vitamin B12 Deficiency: Recognition and Management" 5258:
Pomeranz AJ, Sabnis S, Busey S, Kliegman RM (2016).
3992:. Lippincott Williams & Wilkins. p. PT105. 3102:
Janz TG, Johnson RL, Rubenstein SD (November 2013).
1266:
Peripheral blood smear microscopy of a patient with
8648: 8586: 8347: 8275: 8230: 8139: 8010: 7995: 7920: 7860: 7811: 7707: 7698: 7571: 7556: 7509: 7500: 7493: 7471: 7464: 7379: 7290: 5828:"Physiology or Medicine 1934 – Presentation Speech" 4890: 4888: 2507:, although not specifically anemia. Other types of 1127:, mostly among young women or older women who have 217:. This can be due to a lower than normal number of 184: 172: 161: 140: 128: 107: 98: 83: 51: 46: 4936: 4934: 4744:Portable Fluids and Electrolytes (Portable Series) 4355:By J.L. Jenkins. The Regional Cancer Center. 2001 3471: 3469: 3467: 396:are only recommended in those with severe anemia. 6977:. Archived from the original on January 16, 2009. 6749: 6747: 5860:. St. Louis, MO: Elsevier/Saunders. p. 104. 5343: 5341: 5283:Polin RA, Abman SH, Rowitch D, Benitz WE (2016). 4332:. St. Louis, Mo: Elsevier Saunders. p. 637. 4303:Mitchell RS, Kumar V, Abbas AK, Fausto N (2007). 4159:Mitchell RS, Kumar V, Abbas AK, Fausto N (2007). 3693:"Exercising With Anemia: Prescription for Health" 2849:to ensure sufficient iron for increased rates of 592:(when anemia results from abnormal break down of 492:, shortness of breath, difficulty concentrating, 5230:Hematology: Clinical Principles and Applications 4897:Nature Reviews Gastroenterology & Hepatology 4470:Brooker S, Hotez PJ, Bundy DA (September 2008). 3506: 3504: 3502: 3500: 3498: 2971:are factors. The beliefs of some religions (ex: 1350:also measure the size of the red blood cells by 907:is another defect in membrane skeleton proteins. 561:On examination, the signs exhibited may include 4153: 4151: 4149: 4147: 4145: 4143: 4141: 4139: 4137: 4135: 4133: 4131: 4129: 4127: 4125: 4123: 4121: 2285:(more commonly presenting as normocytic anemia) 1688:shows inadequate production response to anemia. 1321:(amount of RBCs) or the hemoglobin (Hb) in the 957:Hemoglobinopathies causing unstable hemoglobins 739:Disturbance of proliferation and maturation of 5851: 5849: 4457:"Do Hemorrhoids Cause Iron Deficiency Anemia?" 4330:Robbins and Cotran pathologic basis of disease 4119: 4117: 4115: 4113: 4111: 4109: 4107: 4105: 4103: 4101: 846:that prevent normal production of blood cells. 7973: 7438: 6691:Langan RC, Goodbred AJ (September 15, 2017). 6228:. Elsevier Health Sciences. p. 1131.e2. 5908:Robinson's Current Therapy in Equine Medicine 1286:There are a number of definitions of anemia; 620:). In severe anemia, there may be signs of a 419:(SDGs), with anemia as one of the targets in 372:; and if they are normal sized, it is called 266:. When anemia is acute, symptoms may include 8: 7587:Glucose-6-phosphate dehydrogenase deficiency 7109:Hematology/Oncology Clinics of North America 5664:Grantham-McGregor S, Ani C (February 2001). 5555:"Iron Deficiency – United States, 1999–2000" 5495:Lead – Its Effects on Environment and Health 4523:Tropical Medicine & International Health 3610:"WHO Global Anaemia estimates, 2021 Edition" 2441:, or both. Deficiency in folate or vitamin B 933:Glucose-6-phosphate dehydrogenase deficiency 818:Other mechanisms of impaired RBC production 7193:International Journal of Molecular Sciences 6296:The Cochrane Database of Systematic Reviews 5774:Emergency Medicine Clinics of North America 4231:"Overview of hemolytic anemias in children" 3641:. World Health Organization. Archived from 3382: 3380: 3378: 2922:The objective for the administration of an 1133:Many type of cancers, including colorectal 969:Extrinsic (extracorpuscular) abnormalities 771:causes non-pernicious megaloblastic anemia. 471:, Hindi and English language on a board at 356:Anemia can also be classified based on the 8262:Reproductive endocrinology and infertility 8007: 7980: 7966: 7958: 7943:Hereditary persistence of fetal hemoglobin 7704: 7568: 7506: 7497: 7468: 7445: 7431: 7423: 7287: 6488: 6486: 6255:The American Journal of Clinical Nutrition 6251:"Strategies to control nutritional anemia" 6129:"Management of RBC-transfusion dependence" 6122: 6120: 5320:. Univ. Press of Mississippi. p. 23. 4794:"Iron and inflammation - the gut reaction" 4288:: CS1 maint: location missing publisher ( 4229:Despotovic J, Mahoney D, Armsby C (2021). 3436:The American Journal of Clinical Nutrition 3097: 3095: 3093: 3091: 3089: 3087: 3085: 3083: 3081: 3079: 3077: 3075: 3073: 3071: 3069: 2573:from the liver. All three shared the 1934 2544:subacute combined degeneration of the cord 2445:can be due either to inadequate intake or 2308:Various other unstable hemoglobin diseases 1481:'s production of new red blood cells. The 60: 43: 8603:Bachelor of Medicine, Bachelor of Surgery 7895:Mean corpuscular hemoglobin concentration 7717:Warm antibody autoimmune hemolytic anemia 7282:Anemia, U.S. National Library of Medicine 7240:American Journal of Physical Anthropology 7214: 7204: 7120: 7071: 7030: 6885:Undersea and Hyperbaric Medical Society. 6856: 6602: 6553: 6466: 6425: 6315: 6266: 6201:. Elsevier Health Sciences. p. 170. 6174:. Elsevier Health Sciences. p. 534. 6144: 6100: 5956: 5681: 5676:(2S–2): 649S–666S, discussion 666S–668S. 5376:Worldwide prevalence of anaemia 1993–2005 5357: 5186: 5137: 5096: 5020: 5010: 4968: 4958: 4868: 4858: 4817: 4718: 4699:Journal of the American Heart Association 4591: 4581: 4497: 4487: 4397: 4200:"the definition of leukoerythroblastosis" 4092:National Heart, Lung, and Blood Institute 4055: 3927: 3851: 3780:National Heart, Lung, and Blood Institute 3744: 3734: 3585: 3536: 3447: 3161: 3131: 3129: 3067: 3065: 3063: 3061: 3059: 3057: 3055: 3053: 3051: 3049: 2817:In the anemia of chronic kidney disease, 2322:Acquired sideroblastic anemia, including 1194:refers solely to the lack of blood (poor 313:. Causes of decreased production include 6880: 6878: 6876: 6507:10.7326/0003-4819-159-11-201312030-00007 6034:Journal of Pediatric Hematology/Oncology 5981:"MedTerms Definition: Refractory Anemia" 5126:Journal of Human Nutrition and Dietetics 5085:The Proceedings of the Nutrition Society 4163:(8th ed.). Philadelphia: Saunders. 3910:Haas JD, Brownlie T (February 1, 2001). 3401:10.7326/0003-4819-159-11-201312030-00009 1520:When the diagnosis remains difficult, a 1364: 608:deficiency), bone deformities (found in 337:. Causes of increased breakdown include 27:Reduced ability of blood to carry oxygen 7011:Cochrane Database of Systematic Reviews 6912:Hart GB, Lennon PA, Strauss MB (1987). 6837:Cochrane Database of Systematic Reviews 6583:Cochrane Database of Systematic Reviews 6406:Cochrane Database of Systematic Reviews 6402:"Iron therapy for preoperative anaemia" 5906:Peek SF (2015). "Hemolytic Disorders". 4260:. Frizzell, Joan Parker. Philadelphia. 3989:Wintrobe's Atlas of Clinical Hematology 3205: 3203: 3045: 2945:Undersea and Hyperbaric Medical Society 2782:) will replace specific deficiencies. 2554:-deficient anemia was first devised by 2463:, which is required to absorb vitamin B 1477:count is a quantitative measure of the 435:Main symptoms that may appear in anemia 364:. If the cells are small, it is called 6980: 6935: 6887:"Exceptional Blood Loss â€“ Anemia" 6797:Choosing Wisely: an initiative of the 6720: 6718: 6686: 6684: 6682: 5334:from the original on October 31, 2016. 5303:from the original on October 31, 2016. 4841:Guagnozzi D, Lucendo AJ (April 2014). 4792:Verma S, Cherayil BJ (February 2017). 4281: 3635:"WHO | Interventions by global target" 1041:disseminated intravascular coagulation 722:due to insufficient production of the 6657:. Joanna M. Wardlaw. London: Manson. 6225:BOPOD – Ferri's Clinical Advisor 2016 6013:from the original on November 3, 2011 5987:from the original on December 8, 2011 5830:. Nobelprize.org. December 10, 1934. 5444:"How Anemia Is Diagnosed and Treated" 5382:. Geneva: World Health Organization. 3953:European Journal of Internal Medicine 3770: 3768: 3766: 3764: 3668: 3666: 2486:surgery, leading to reduced vitamin B 2235: 2233: 2231: 2229: 2222: 2220: 2218: 2216: 2214: 2212: 2205: 2203: 2201: 2199: 2197: 2195: 2193: 2191: 2165: 2163: 2161: 2159: 2157: 2131: 2129: 2127: 2125: 2123: 2121: 2119: 2117: 2107: 2105: 2103: 2101: 2099: 2097: 2091: 2089: 2087: 2085: 2083: 2081: 2075: 2073: 2071: 2069: 2025: 1983: 1981: 1979: 1977: 1971: 1969: 1967: 1965: 1963: 1961: 1959: 1957: 1954: 1952: 1950: 1948: 1946: 1944: 1942: 1940: 1938: 1936: 1934: 1932: 1901: 1899: 1897: 1895: 1889: 1887: 1885: 1879: 1877: 1871: 1839: 1837: 1835: 1833: 1831: 1801: 1795: 1788: 1786: 1783: 1781: 1778: 1776: 1748: 1746: 1744: 1742: 1740: 1714: 1712: 1706: 1704: 1702: 1696: 1694: 1692: 1690: 1684: 1682: 1680: 1678: 1676: 1674: 1652: 1650: 1648: 1646: 1624: 1622: 1620: 1618: 1616: 1614: 1608: 1606: 1604: 1602: 1600: 1598: 1595: 1593: 1591: 1589: 1587: 1585: 1583: 1581: 1579: 1342:. Apart from reporting the number of 1029:Mechanical trauma to red blood cells 643:(enlargement). There may be signs of 272:feeling like one is going to pass out 7: 8741: 8502:Physical medicine and rehabilitation 7604:triosephosphate isomerase deficiency 6758:. 13 Suppl 3 (Supplement 3): 33–36. 6728:. September 14, 2017. Archived from 5834:from the original on August 28, 2010 5260:Pediatric Decision-Making Strategies 5247:from the original on April 25, 2016. 4353:"Autoimmune Hemolytic Anemia (AIHA)" 4235:The Lecturio Medical Concept Library 3511:Vos T, et al. (December 2012). 3292:The American Journal of Managed Care 2279:(microcytosis is not always present) 1239:Gluten-related disorders: untreated 913:, causing defects in membrane lipids 810:, causing ineffective erythropoiesis 808:Congenital dyserythropoietic anemias 804:, causing deficient globin synthesis 760:dependent on impaired absorption of 8751: 7759:paroxysmal nocturnal hemoglobinuria 7727:Donath–Landsteiner hemolytic anemia 6813:from the original on April 16, 2012 5399:from the original on March 12, 2009 3673:eMedicineHealth > anemia article 3136:Vos T, et al. (October 2016). 2947:. The use of HBO is indicated when 2898:levels, the cause must be treated. 2522:, and other substances may inhibit 1338:Anemia is typically diagnosed on a 1037:thrombotic thrombocytopenic purpura 963:Paroxysmal nocturnal hemoglobinuria 885:paroxysmal nocturnal hemoglobinuria 8638:Medical Scientist Training Program 6963:Undersea & Hyperbaric Medicine 6381:from the original on June 24, 2013 5916:10.1016/B978-1-4557-4555-5.00117-5 5373:World Health Organization (2008). 5161:Beutler E, Waalen J (March 2006). 3246:from the original on July 14, 2014 2595:) remains normal. Causes include: 1570:with signs of hemolysis; elevated 1561:Production vs. destruction or loss 1033:Microangiopathic hemolytic anemias 516:, easy bruising and bleeding, and 467:Symptoms of anemia are written in 368:; if they are large, it is called 25: 7768:Microangiopathic hemolytic anemia 7739:Mixed autoimmune hemolytic anemia 5941:"Laboratory evaluation of anemia" 4947:World Journal of Gastroenterology 4847:World Journal of Gastroenterology 2918:Erythropoiesis-stimulating agents 2742:. This iron overload may require 394:Erythropoiesis-stimulating agents 362:amount of hemoglobin in each cell 8770: 8760: 8750: 8740: 8731: 8730: 7799:Hemolytic disease of the newborn 7158:10.1111/j.1365-2141.2011.08761.x 6353:10.1046/j.1525-1594.2002.06888.x 6046:10.1097/00043426-200302000-00018 5983:. Medterms.com. April 27, 2011. 5577:from the original on May 5, 2012 5139:10.1111/j.1365-277X.2011.01171.x 4535:10.1111/j.1365-3156.2011.02727.x 4476:PLOS Neglected Tropical Diseases 3004: 2924:erythropoiesis-stimulating agent 1415:Women, non-pregnant (>15yrs) 1014:hemolytic disease of the newborn 1004:Cold agglutinin hemolytic anemia 979:Warm autoimmune hemolytic anemia 871:. These types generally feature 663:than in the general population. 500:heartbeat, cold hands and feet, 490:intolerance to physical exertion 423:for achieving zero world hunger. 91: 8771: 6468:10.1182/asheducation-2010.1.338 6146:10.1182/asheducation-2007.1.398 5945:The Western Journal of Medicine 3657:"The case for action on anemia" 3483:(Press release). April 26, 2019 2967:incompatibility or concern for 2328:Reversible sideroblastic anemia 2319:Hereditary sideroblastic anemia 297:. Causes of blood loss include 221:, a reduction in the amount of 213:has a reduced ability to carry 8628:Doctor of Osteopathic Medicine 8062:Oral and maxillofacial surgery 7732:Paroxysmal cold hemoglobinuria 7146:British Journal of Haematology 7060:British Journal of Haematology 7023:10.1002/14651858.CD012451.pub2 6849:10.1002/14651858.CD012451.pub2 6804:American Society of Nephrology 6786:American Society of Nephrology 6764:10.1634/theoncologist.13-S3-33 6595:10.1002/14651858.CD009007.pub2 6449:Auerbach M, Ballard H (2010). 6418:10.1002/14651858.CD011588.pub3 6308:10.1002/14651858.CD009747.pub2 4044:American Journal of Hematology 3776:"What Are Symptoms of Anemia?" 3266:"Anemia - Symptoms and causes" 1346:and the hemoglobin level, the 1113:) or chronic blood loss (e.g. 939:deficiency, causing increased 659:is more common in people with 1: 7105:"The Global Burden of Anemia" 6831:Kaufner L, Heymann C (2020). 6195:Mandel J, Taichman D (2006). 6093:10.1016/j.leukres.2010.07.015 6009:. Atlasgeneticsoncology.org. 5939:Wallerstein RO (April 1987). 5751:10.1016/s0140-6736(73)91446-3 5352:. World Health Organization. 5286:Fetal and Neonatal Physiology 4660:Recenti Progressi in Medicina 3889:10.1016/s0140-6736(10)62304-5 3844:10.1016/s2214-109x(13)70001-9 3578:10.1016/S0140-6736(14)61682-2 3529:10.1016/S0140-6736(12)61729-2 3353:10.1016/S0140-6736(13)60996-4 3154:10.1016/S0140-6736(16)31678-6 2550:. The treatment for vitamin B 1698:Reticulocyte production index 1686:Reticulocyte production index 1483:reticulocyte production index 1302:concentration of more than 2 1298:is a decrease in whole-blood 1245:non-celiac gluten sensitivity 926:deficiencies, causing defect 554:of the legs, and symptoms of 417:Sustainable Development Goals 228:The name is derived from 8608:Bachelor of Medical Sciences 8375:Neurosurgical anesthesiology 7683:Southeast Asian ovalocytosis 7671:Minkowski–Chauffard syndrome 6127:Melchert M, List AF (2007). 5543:MMWR 1998;47 (No. RR-3) p. 5 5058:10.1053/j.gastro.2005.02.007 4768:"ISBT: 8. Obstetric anaemia" 4629:10.1097/NAN.0000000000000121 4489:10.1371/journal.pntd.0000291 4435:10.1016/j.vetpar.2007.05.005 3723:Journal of Clinical Medicine 2678:, for example, after eating 2511:can also cause macrocytosis. 2247:may point to a cause in the 1541:), the anemia is said to be 998:chronic lymphocytic leukemia 994:systemic lupus erythematosus 867:are generally classified as 179:Blood hemoglobin measurement 6495:Annals of Internal Medicine 5601:Data Bridge Market Research 4617:Journal of Infusion Nursing 4256:Capriotti, Theresa (2016). 3389:Annals of Internal Medicine 3294:. 16 Suppl Issues: S59–66. 3108:Emergency Medicine Practice 1793:production to compensate**. 1310:of an age- and sex-matched 996:, or a malignancy, such as 358:size of the red blood cells 264:reduced ability to exercise 8823: 7792:Drug-induced nonautoimmune 7773:Thrombotic microangiopathy 7599:pyruvate kinase deficiency 6198:Pulmonary Vascular Disease 5262:(2nd ed.). Elsevier. 5179:10.1182/blood-2005-07-3046 3965:10.1016/j.ejim.2017.04.018 2584: 2419: 2367:Fecal occult blood testing 2258: 1507:hemoglobin electrophoresis 1251:Inflammatory bowel disease 1148:feeding on blood, such as 1102:, causing acute blood loss 865:red blood cell destruction 856: 550:is present), intermittent 31: 8726: 7778:Hemolytic–uremic syndrome 7690:Hereditary stomatocytosis 7678:Hereditary elliptocytosis 7277:WHO fact sheet on anaemia 7122:10.1016/j.hoc.2015.11.002 6987:: CS1 maint: unfit URL ( 6942:: CS1 maint: unfit URL ( 6697:American Family Physician 6249:West CE (November 1996). 5786:10.1016/j.emc.2018.04.009 5503:10.1515/9783110434330-016 5098:10.1017/S0029665111000097 4909:10.1038/nrgastro.2015.131 4583:10.1186/s13054-019-2511-9 4390:10.1080/10245330701445392 3614:Wolrd Health Organization 3319:. StatPearls Publishing. 2607:Anemia of chronic disease 2283:Anemia of chronic disease 2185: 2183: 2181: 2179: 2177: 2175: 2173: 2155: 2151: 2149: 2147: 2141: 2139: 2137: 2063: 2061: 2059: 2057: 2055: 2053: 2051: 2045: 2043: 2041: 2039: 2037: 2035: 2033: 2023: 2019: 2017: 2015: 2013: 2011: 2009: 2007: 2001: 1999: 1997: 1995: 1993: 1991: 1989: 1865: 1863: 1861: 1859: 1853: 1851: 1829: 1825: 1823: 1821: 1819: 1813: 1811: 1770: 1768: 1766: 1760: 1758: 1756: 1738: 1734: 1732: 1730: 1724: 1722: 1720: 1668: 1666: 1664: 1662: 1660: 1644: 1640: 1638: 1632: 1630: 1465:, genetic testing, and a 905:Hereditary elliptocytosis 875:, and elevated levels of 188:2.36 billion / 33% (2015) 68: 59: 55:Anaemia, erythrocytopenia 8562:Transplantation medicine 8453:Clinical neurophysiology 8370:Obstetric anesthesiology 8290:Interventional radiology 8050:Digestive system surgery 7666:Hereditary spherocytosis 5670:The Journal of Nutrition 5348:Organization WH (2011). 5079:Lomer MC (August 2011). 4960:10.3748/wjg.v22.i35.7908 4860:10.3748/wjg.v20.i13.3542 4359:October 7, 2009, at the 4014:"Mental Health and Pica" 3916:The Journal of Nutrition 3832:The Lancet Global Health 3114:(11): 1–15, quiz 15–16. 2882:In many cases, vitamin B 2878:intramuscular injections 2689:which eat dry or wilted 2471:condition targeting the 1144:Infection by intestinal 895:Hereditary spherocytosis 832:Myelodysplastic syndrome 622:hyperdynamic circulation 295:red blood cell breakdown 289:Anemia can be caused by 239: 'not' and 8433:Intensive care medicine 8407:Mass gathering medicine 8252:Maternal–fetal medicine 7871:Mean corpuscular volume 7835:Diamond–Blackfan anemia 7787:Drug-induced autoimmune 7722:Cold agglutinin disease 7528:Plummer–Vinson syndrome 6555:10.1136/gut.2010.228874 6007:"Good Source for later" 5635:10.1542/peds.107.6.1381 4711:10.1161/JAHA.114.001480 4423:Veterinary Parasitology 4305:Robbins Basic Pathology 4161:Robbins Basic Pathology 3659:. Devex. June 14, 2016. 3449:10.3945/ajcn.114.103366 2888:intramuscular injection 2863:coronary artery disease 2593:mean corpuscular volume 2575:Nobel Prize in Medicine 2459:is caused by a lack of 2447:insufficient absorption 2347:heavy menstrual periods 1535:mean corpuscular volume 1522:bone marrow examination 1382:Children (0.5–5.0 yrs) 1218:Intestinal inflammation 1167:The roots of the words 1012:, one of the causes of 641:ventricular hypertrophy 385:Dietary supplementation 34:Anemia (disambiguation) 8025:Cardiothoracic surgery 7523:Iron-deficiency anemia 2928:chronic kidney disease 2775:) or intramuscularly ( 2363:gastrointestinal tract 2277:Iron-deficiency anemia 1568:peripheral blood smear 1377:Hb threshold (mmol/L) 1296:operational definition 1278: 1270: 1268:iron-deficiency anemia 1068:Trypanosoma congolense 1045:Infections, including 937:glutathione synthetase 676: 661:iron-deficiency anemia 657:Restless legs syndrome 588:(in iron deficiency), 480: 444: 436: 401:Iron-deficiency anemia 74:iron-deficiency anemia 8676:Personalized medicine 8535:Reproductive medicine 8460:Occupational medicine 8414:Evolutionary medicine 7842:Pure red cell aplasia 7609:hexokinase deficiency 6957:Van Meter KW (2005). 6732:on September 14, 2017 6268:10.1093/ajcn/64.5.789 5683:10.1093/jn/131.2.649S 4088:"Sickle Cell Disease" 3929:10.1093/jn/131.2.676s 3211:"Anemia | NHLBI, NIH" 2969:transmissible disease 2910:deficiency or severe 2832:is also recommended. 2730:Transfusion dependent 2614:(bone marrow failure) 2540:peripheral neuropathy 1276: 1265: 1090:Anemia of prematurity 877:lactate dehydrogenase 863:Anemias of increased 857:Further information: 853:Increased destruction 789:Anemia of prematurity 707:affects all kinds of 700:Pure red cell aplasia 674: 628:(a fast heart rate), 466: 442: 434: 413:World Health Assembly 345:, infections such as 276:loss of consciousness 8807:Transfusion medicine 8696:Traditional medicine 8656:Alternative medicine 8523:Addiction psychiatry 8337:Transfusion medicine 8332:Medical microbiology 8247:Gynecologic oncology 8099:Reproductive surgery 7847:Sideroblastic anemia 7655:Hemoglobin C disease 7541:Megaloblastic anemia 7206:10.3390/ijms21186976 6377:. February 9, 2011. 5910:. pp. 492–495. 5317:Understanding Anemia 4742:"Fluid imbalances". 4186:Williams Hermatology 3148:(10053): 1545–1602. 2428:Megaloblastic anemia 1393:Children (5–12 yrs) 1374:Hb threshold (g/dL) 1371:Age or gender group 1340:complete blood count 1019:Transfusion reaction 988:diseases. It can be 916:Enzyme deficiencies 911:Abetalipoproteinemia 838:chronic inflammation 822:Myelophthisic anemia 784:megaloblastic anemia 750:megaloblastic anemia 32:For other uses, see 8718:History of medicine 8701:Veterinary medicine 8508:Preventive medicine 8360:Adolescent medicine 8202:Infectious diseases 7646:Sickle cell disease 4210:on December 2, 2018 3883:(9809): 2123–2135. 3736:10.3390/jcm12030921 3645:on August 14, 2016. 3523:(9859): 2163–2196. 2979:Preoperative anemia 2973:Jehovah's Witnesses 2759:, aplastic anemia, 2674:after ingestion of 2538:deficiency include 1528:Red blood cell size 1367: 1304:standard deviations 1233:Helicobacter pylori 1183:used alone implies 1155:Trichuris trichiura 778:, as with vitamin B 767:. Lack of dietary B 691:Impaired production 618:sickle-cell disease 454:shortness of breath 351:autoimmune diseases 256:shortness of breath 155:shortness of breath 76:, with small, pale 8666:Molecular oncology 8623:Doctor of Medicine 8613:Master of Medicine 8530:Radiation oncology 8402:Emergency medicine 8355:Addiction medicine 8322:Clinical chemistry 8317:Clinical pathology 8109:Transplant surgery 8067:Orthopedic surgery 8045:Colorectal surgery 7933:Sulfhemoglobinemia 7380:External resources 6654:Clinical neurology 6651:Hankey GJ (2008). 5856:Harvey JW (2012). 5813:2007-03-15 at the 5539:2007-04-20 at the 4810:10.1039/c6mt00282j 4204:www.dictionary.com 3986:Weksler B (2017). 3806:www.hematology.org 3678:2009-04-17 at the 3188:. November 9, 2021 3016:. You can help by 2953:blood transfusions 2857:Blood transfusions 2765:sickle cell anemia 2682:minted after 1982. 2503:commonly causes a 2356:angular stomatitis 1883:(80<MCV<100) 1467:bone marrow sample 1404:Teens (12–15 yrs) 1365: 1348:automatic counters 1279: 1271: 1137:and cancer of the 1023:blood transfusions 953:Sickle cell anemia 948:Hemoglobinopathies 677: 481: 445: 437: 427:Signs and symptoms 389:blood transfusions 343:sickle cell anemia 335:bone marrow tumors 8784: 8783: 8618:Master of Surgery 8582: 8581: 8567:Tropical medicine 8513:Prison healthcare 8428:Hospital medicine 8392:Disaster medicine 8382:Aviation medicine 8197:Hospital medicine 8104:Surgical oncology 8089:Pediatric surgery 8083: 8030:Endocrine surgery 7955: 7954: 7951: 7950: 7938:Reticulocytopenia 7928:Methemoglobinemia 7916: 7915: 7807: 7806: 7747: 7746: 7546:Pernicious anemia 7489: 7488: 7481:Polycythemia vera 7420: 7419: 7073:10.1111/bjh.13623 6918:J. Hyperbaric Med 6664:978-1-84076-518-2 6341:Artificial Organs 6222:Ferri FF (2015). 6081:Leukemia Research 5925:978-1-4557-4555-5 5892:978-1-119-03652-4 5867:978-1-4377-0173-9 5809:, July 18, 2006. 5512:978-3-11-043433-0 5423:Radiologyinfo.org 5389:978-92-4-159665-7 5327:978-1-60473-701-1 5314:Uthman E (2009). 5296:978-0-323-35232-1 5269:978-0-323-29854-4 5240:978-1-4160-3006-5 5227:Rodak BF (2007). 5012:10.3390/nu5103839 5005:(10): 3839–3853. 4953:(35): 7908–7925. 4853:(13): 3542–3551. 4753:978-1-58255-678-9 4339:978-0-7216-0187-8 4314:978-1-4160-2973-1 4267:978-0-8036-1571-7 4170:978-1-4160-2973-1 4057:10.1002/ajh.23397 3347:(9890): 452–477. 3215:www.nhlbi.nih.gov 3034: 3033: 2941:hyperbaric oxygen 2935:Hyperbaric oxygen 2808:ferrous gluconate 2744:chelation therapy 2710:Refractory anemia 2638:Heinz body anemia 2587:Normocytic anemia 2457:Pernicious anemia 2453:deficiency does. 2422:Macrocytic anemia 2383:colorectal cancer 2296:Alpha-, and beta- 2293:synthesis defect 2273:synthesis defect 2261:Microcytic anemia 2245:white blood cells 2241: 2240: 2109:Microcytic anemia 2093:Normocytic anemia 2077:Macrocytic anemia 1907: 1906: 1891:Microcytic anemia 1881:Normocytic anemia 1873:Macrocytic anemia 1447: 1446: 1161:Iatrogenic anemia 1152:and the whipworm 889:genetic disorders 887:, are hereditary 869:hemolytic anemias 776:folate deficiency 746:Pernicious anemia 733:endocrine disease 604:damage (vitamin B 546:(if pre-existing 374:normocytic anemia 370:macrocytic anemia 366:microcytic anemia 339:genetic disorders 319:folate deficiency 192: 191: 174:Diagnostic method 41:Medical condition 16:(Redirected from 8814: 8774: 8773: 8764: 8754: 8753: 8744: 8743: 8734: 8733: 8438:Medical genetics 8423:General practice 8300:Nuclear medicine 8175:Gastroenterology 8131:Vascular surgery 8081: 8008: 7982: 7975: 7968: 7959: 7705: 7619:hemoglobinopathy 7569: 7507: 7498: 7469: 7447: 7440: 7433: 7424: 7288: 7264: 7263: 7235: 7229: 7228: 7218: 7208: 7184: 7178: 7177: 7141: 7135: 7134: 7124: 7100: 7094: 7093: 7075: 7051: 7045: 7044: 7034: 7002: 6993: 6992: 6986: 6978: 6954: 6948: 6947: 6941: 6933: 6931: 6929: 6909: 6903: 6902: 6900: 6898: 6889:. Archived from 6882: 6871: 6870: 6860: 6828: 6822: 6821: 6820: 6818: 6812: 6794: 6782: 6776: 6775: 6751: 6742: 6741: 6739: 6737: 6722: 6713: 6712: 6688: 6677: 6676: 6648: 6642: 6641: 6639: 6637: 6623: 6617: 6616: 6606: 6574: 6568: 6567: 6557: 6533: 6527: 6526: 6490: 6481: 6480: 6470: 6446: 6440: 6439: 6429: 6412:(12): CD011588. 6397: 6391: 6390: 6388: 6386: 6371: 6365: 6364: 6336: 6330: 6329: 6319: 6287: 6281: 6280: 6270: 6246: 6240: 6239: 6219: 6213: 6212: 6192: 6186: 6185: 6165: 6159: 6158: 6148: 6124: 6115: 6114: 6104: 6072: 6066: 6065: 6029: 6023: 6022: 6020: 6018: 6003: 5997: 5996: 5994: 5992: 5977: 5971: 5970: 5960: 5936: 5930: 5929: 5903: 5897: 5896: 5878: 5872: 5871: 5853: 5844: 5843: 5841: 5839: 5824: 5818: 5804: 5798: 5797: 5769: 5763: 5762: 5734: 5728: 5727: 5725: 5723: 5717: 5711:. 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June 26, 2018. 4453: 4447: 4446: 4418: 4412: 4411: 4401: 4369: 4363: 4350: 4344: 4343: 4325: 4319: 4318: 4300: 4294: 4293: 4287: 4279: 4253: 4247: 4246: 4244: 4242: 4226: 4220: 4219: 4217: 4215: 4206:. Archived from 4196: 4190: 4189: 4181: 4175: 4174: 4155: 4096: 4095: 4094:. July 22, 2022. 4084: 4078: 4077: 4059: 4035: 4029: 4028: 4026: 4024: 4010: 4004: 4003: 3983: 3977: 3976: 3948: 3942: 3941: 3931: 3922:(2): 676S–690S. 3907: 3901: 3900: 3872: 3866: 3865: 3855: 3823: 3817: 3816: 3814: 3812: 3798: 3792: 3791: 3789: 3787: 3782:. March 24, 2022 3772: 3759: 3758: 3748: 3738: 3714: 3708: 3707: 3705: 3703: 3689: 3683: 3670: 3661: 3660: 3653: 3647: 3646: 3631: 3625: 3624: 3622: 3620: 3606: 3600: 3599: 3589: 3572:(9963): 117–71. 3557: 3551: 3550: 3540: 3508: 3493: 3492: 3490: 3488: 3473: 3462: 3461: 3451: 3442:(6): 1585–1594. 3427: 3421: 3420: 3384: 3373: 3372: 3335: 3329: 3328: 3310: 3304: 3303: 3287: 3281: 3280: 3278: 3276: 3262: 3256: 3255: 3253: 3251: 3232: 3226: 3225: 3223: 3221: 3207: 3198: 3197: 3195: 3193: 3182: 3176: 3175: 3165: 3133: 3124: 3123: 3099: 3029: 3026: 3008: 3001: 2804:ferrous fumarate 2761:hemolytic anemia 2736:Beta thalassemia 2618:Hemolytic anemia 2461:intrinsic factor 1930: 1929: 1577: 1576: 1515:serum creatinine 1503:RBC folate level 1437:Men (>15yrs) 1426:Women, pregnant 1368: 941:oxidative stress 859:Hemolytic anemia 598:hemolytic anemia 502:cold intolerance 383:for prevention. 333:and a number of 301:, bleeding from 280:increased thirst 120: 119: 116: 115: 112: 109: 106: 103: 100: 97: 64: 44: 21: 8822: 8821: 8817: 8816: 8815: 8813: 8812: 8811: 8802:Hematopathology 8787: 8786: 8785: 8780: 8722: 8711:Chief physician 8644: 8589: 8578: 8572:Travel medicine 8557:Sports medicine 8540:Sexual medicine 8480:Palliative care 8475:Pain management 8419:Family medicine 8397:Diving medicine 8343: 8271: 8233: 8226: 8142: 8135: 8094:Plastic surgery 8040:General surgery 8020:Cardiac surgery 8001: 7999: 7991: 7986: 7956: 7947: 7912: 7856: 7815: 7803: 7743: 7694: 7560: 7552: 7485: 7460: 7458:red blood cells 7451: 7421: 7416: 7415: 7375: 7374: 7299: 7273: 7268: 7267: 7237: 7236: 7232: 7186: 7185: 7181: 7143: 7142: 7138: 7102: 7101: 7097: 7053: 7052: 7048: 7017:(8): CD012451. 7004: 7003: 6996: 6979: 6956: 6955: 6951: 6934: 6927: 6925: 6911: 6910: 6906: 6896: 6894: 6893:on July 5, 2008 6884: 6883: 6874: 6843:(8): CD012451. 6830: 6829: 6825: 6816: 6814: 6810: 6799:ABIM Foundation 6792: 6784: 6783: 6779: 6753: 6752: 6745: 6735: 6733: 6724: 6723: 6716: 6690: 6689: 6680: 6665: 6650: 6649: 6645: 6635: 6633: 6631:medlineplus.gov 6625: 6624: 6620: 6589:(2): CD009007. 6576: 6575: 6571: 6535: 6534: 6530: 6501:(11): 746–757. 6492: 6491: 6484: 6448: 6447: 6443: 6399: 6398: 6394: 6384: 6382: 6373: 6372: 6368: 6338: 6337: 6333: 6302:(4): CD009747. 6289: 6288: 6284: 6248: 6247: 6243: 6236: 6221: 6220: 6216: 6209: 6194: 6193: 6189: 6182: 6167: 6166: 6162: 6126: 6125: 6118: 6074: 6073: 6069: 6031: 6030: 6026: 6016: 6014: 6005: 6004: 6000: 5990: 5988: 5979: 5978: 5974: 5938: 5937: 5933: 5926: 5905: 5904: 5900: 5893: 5880: 5879: 5875: 5868: 5855: 5854: 5847: 5837: 5835: 5826: 5825: 5821: 5815:Wayback Machine 5805: 5801: 5771: 5770: 5766: 5736: 5735: 5731: 5721: 5719: 5718:on May 16, 2011 5715: 5708: 5704: 5703: 5699: 5663: 5662: 5658: 5620: 5619: 5615: 5605: 5603: 5595: 5594: 5590: 5580: 5578: 5565:(40): 897–899. 5552: 5551: 5547: 5541:Wayback Machine 5532: 5528: 5513: 5492: 5491: 5487: 5477: 5475: 5473:eMedicineHealth 5467: 5466: 5462: 5452: 5450: 5442: 5441: 5437: 5427: 5425: 5417: 5416: 5412: 5402: 5400: 5396: 5390: 5379: 5372: 5371: 5367: 5347: 5346: 5339: 5328: 5313: 5312: 5308: 5297: 5282: 5281: 5277: 5270: 5257: 5256: 5252: 5241: 5226: 5225: 5221: 5208: 5204: 5160: 5159: 5155: 5119: 5118: 5114: 5078: 5077: 5073: 5043: 5042: 5038: 4991: 4990: 4986: 4940: 4939: 4932: 4903:(10): 561–571. 4894: 4893: 4886: 4840: 4839: 4835: 4791: 4790: 4786: 4776: 4774: 4772:www.isbtweb.org 4766: 4765: 4761: 4754: 4741: 4740: 4736: 4692: 4691: 4687: 4657: 4656: 4652: 4614: 4613: 4609: 4563: 4562: 4558: 4520: 4519: 4515: 4469: 4468: 4464: 4455: 4454: 4450: 4420: 4419: 4415: 4371: 4370: 4366: 4361:Wayback Machine 4351: 4347: 4340: 4327: 4326: 4322: 4315: 4302: 4301: 4297: 4280: 4268: 4255: 4254: 4250: 4240: 4238: 4228: 4227: 4223: 4213: 4211: 4198: 4197: 4193: 4183: 4182: 4178: 4171: 4158: 4157:Table 12-1 in: 4156: 4099: 4086: 4085: 4081: 4037: 4036: 4032: 4022: 4020: 4012: 4011: 4007: 4000: 3985: 3984: 3980: 3950: 3949: 3945: 3909: 3908: 3904: 3874: 3873: 3869: 3825: 3824: 3820: 3810: 3808: 3800: 3799: 3795: 3785: 3783: 3774: 3773: 3762: 3716: 3715: 3711: 3701: 3699: 3691: 3690: 3686: 3680:Wayback Machine 3671: 3664: 3655: 3654: 3650: 3633: 3632: 3628: 3618: 3616: 3608: 3607: 3603: 3559: 3558: 3554: 3510: 3509: 3496: 3486: 3484: 3475: 3474: 3465: 3429: 3428: 3424: 3395:(11): 770–779. 3386: 3385: 3376: 3337: 3336: 3332: 3312: 3311: 3307: 3289: 3288: 3284: 3274: 3272: 3264: 3263: 3259: 3249: 3247: 3234: 3233: 3229: 3219: 3217: 3209: 3208: 3201: 3191: 3189: 3184: 3183: 3179: 3135: 3134: 3127: 3101: 3100: 3047: 3042: 3030: 3024: 3021: 3014:needs expansion 2999: 2990: 2981: 2937: 2920: 2908: 2904: 2897: 2893: 2885: 2880: 2877: 2859: 2842:parenteral iron 2838: 2836:Injectable iron 2830:parenteral iron 2800:ferrous sulfate 2792: 2780: 2774: 2752: 2732: 2724:occult bleeding 2720:iron absorption 2712: 2700: 2663:, for example, 2640: 2627: 2622: 2612:Aplastic anemia 2589: 2583: 2571: 2553: 2537: 2524:DNA replication 2489: 2478: 2466: 2452: 2444: 2435: 2424: 2418: 2398:schistosomiasis 2375:lower endoscopy 2371:upper endoscopy 2333: 2263: 2257: 1919: 1916: 1563: 1551:iron deficiency 1530: 1463: 1344:red blood cells 1336: 1312:reference range 1284: 1260: 1220: 1204: 1139:urinary bladder 1086: 920:Pyruvate kinase 861: 855: 781: 770: 765: 757: 705:Aplastic anemia 693: 685:iron deficiency 669: 607: 594:red blood cells 518:muscle weakness 429: 326: 315:iron deficiency 219:red blood cells 203:British English 157:, feeling faint 124: 94: 90: 78:red blood cells 42: 37: 28: 23: 22: 15: 12: 11: 5: 8820: 8818: 8810: 8809: 8804: 8799: 8789: 8788: 8782: 8781: 8779: 8778: 8768: 8758: 8748: 8738: 8727: 8724: 8723: 8721: 8720: 8715: 8714: 8713: 8703: 8698: 8693: 8688: 8683: 8678: 8673: 8668: 8663: 8658: 8652: 8650: 8649:Related topics 8646: 8645: 8643: 8642: 8641: 8640: 8630: 8625: 8620: 8615: 8610: 8605: 8600: 8598:Medical school 8594: 8592: 8584: 8583: 8580: 8579: 8577: 8576: 8575: 8574: 8564: 8559: 8554: 8552:Sleep medicine 8549: 8548: 8547: 8537: 8532: 8527: 8526: 8525: 8515: 8510: 8505: 8499: 8494: 8493: 8492: 8482: 8477: 8472: 8467: 8462: 8457: 8456: 8455: 8445: 8440: 8435: 8430: 8425: 8416: 8411: 8410: 8409: 8399: 8394: 8389: 8384: 8379: 8378: 8377: 8372: 8365:Anesthesiology 8362: 8357: 8351: 8349: 8345: 8344: 8342: 8341: 8340: 8339: 8334: 8329: 8324: 8319: 8314: 8304: 8303: 8302: 8297: 8295:Neuroradiology 8292: 8281: 8279: 8273: 8272: 8270: 8269: 8264: 8259: 8254: 8249: 8244: 8238: 8236: 8232:Obstetrics and 8228: 8227: 8225: 8224: 8219: 8214: 8209: 8204: 8199: 8194: 8189: 8184: 8183: 8182: 8172: 8167: 8162: 8157: 8147: 8145: 8137: 8136: 8134: 8133: 8128: 8127: 8126: 8116: 8114:Trauma surgery 8111: 8106: 8101: 8096: 8091: 8086: 8085: 8084: 8077:Otolaryngology 8074: 8069: 8064: 8059: 8054: 8053: 8052: 8047: 8037: 8032: 8027: 8022: 8016: 8014: 8005: 8003:subspecialties 7993: 7992: 7987: 7985: 7984: 7977: 7970: 7962: 7953: 7952: 7949: 7948: 7946: 7945: 7940: 7935: 7930: 7924: 7922: 7918: 7917: 7914: 7913: 7911: 7910: 7909: 7908: 7903: 7891: 7890: 7889: 7884: 7879: 7866: 7864: 7858: 7857: 7855: 7854: 7849: 7844: 7837: 7832: 7830:Fanconi anemia 7823: 7821: 7809: 7808: 7805: 7804: 7802: 7801: 7795: 7794: 7789: 7783: 7782: 7781: 7780: 7770: 7764: 7763: 7762: 7761: 7748: 7745: 7744: 7742: 7741: 7736: 7735: 7734: 7724: 7719: 7713: 7711: 7702: 7696: 7695: 7693: 7692: 7687: 7686: 7685: 7675: 7674: 7673: 7657: 7652: 7643: 7642: 7641: 7636: 7631: 7614: 7613: 7612: 7611: 7606: 7601: 7589: 7577: 7575: 7566: 7554: 7553: 7551: 7550: 7549: 7548: 7533: 7532: 7531: 7530: 7515: 7513: 7504: 7495: 7491: 7490: 7487: 7486: 7484: 7483: 7477: 7475: 7466: 7462: 7461: 7452: 7450: 7449: 7442: 7435: 7427: 7418: 7417: 7414: 7413: 7396: 7384: 7383: 7381: 7377: 7376: 7373: 7372: 7361: 7350: 7339: 7320: 7300: 7295: 7294: 7292: 7291:Classification 7285: 7284: 7279: 7272: 7271:External links 7269: 7266: 7265: 7230: 7179: 7136: 7115:(2): 247–308. 7095: 7066:(3): 322–331. 7046: 6994: 6949: 6904: 6872: 6823: 6777: 6756:The Oncologist 6743: 6714: 6703:(6): 384–389. 6678: 6663: 6643: 6618: 6569: 6528: 6482: 6441: 6392: 6366: 6347:(4): 366–370. 6331: 6282: 6261:(5): 789–790. 6241: 6235:978-0323378222 6234: 6214: 6208:978-1416022466 6207: 6187: 6180: 6160: 6116: 6067: 6040:(2): 169–172. 6024: 5998: 5972: 5951:(4): 443–451. 5931: 5924: 5898: 5891: 5873: 5866: 5845: 5819: 5799: 5780:(3): 609–630. 5764: 5729: 5697: 5656: 5613: 5588: 5545: 5526: 5511: 5485: 5460: 5435: 5410: 5388: 5365: 5337: 5326: 5306: 5295: 5275: 5268: 5250: 5239: 5219: 5202: 5153: 5132:(4): 313–326. 5112: 5091:(3): 329–335. 5071: 5036: 4984: 4930: 4884: 4833: 4804:(2): 101–111. 4784: 4759: 4752: 4734: 4705:(1): e001480. 4685: 4666:(3): 153–164. 4662:(in Italian). 4650: 4623:(5): 330–338. 4607: 4556: 4529:(4): 531–537. 4513: 4462: 4448: 4413: 4384:(5): 361–370. 4364: 4345: 4338: 4320: 4313: 4295: 4266: 4248: 4221: 4191: 4188:. McGraw-Hill. 4176: 4169: 4097: 4079: 4050:(4): 261–264. 4030: 4005: 3998: 3978: 3943: 3902: 3867: 3838:(1): e16–e25. 3818: 3793: 3760: 3709: 3684: 3662: 3648: 3626: 3601: 3552: 3494: 3463: 3422: 3374: 3330: 3305: 3282: 3257: 3240:Dictionary.com 3227: 3199: 3177: 3125: 3044: 3043: 3041: 3038: 3032: 3031: 3011: 3009: 2998: 2995: 2989: 2986: 2980: 2977: 2936: 2933: 2919: 2916: 2906: 2902: 2895: 2891: 2883: 2879: 2875: 2872: 2858: 2855: 2851:erythropoiesis 2847:erythropoietin 2837: 2834: 2822:erythropoietin 2791: 2788: 2778: 2772: 2751: 2748: 2731: 2728: 2711: 2708: 2706:is below 10%. 2699: 2696: 2695: 2694: 2683: 2668: 2639: 2636: 2626: 2623: 2621: 2620: 2615: 2609: 2604: 2597: 2585:Main article: 2582: 2579: 2569: 2564:George Whipple 2556:William Murphy 2551: 2535: 2531: 2530: 2514:Drugs such as 2512: 2498: 2496:Hypothyroidism 2493: 2492: 2491: 2487: 2484:gastric bypass 2480: 2476: 2473:parietal cells 2464: 2450: 2442: 2433: 2420:Main article: 2417: 2414: 2406: 2405: 2386: 2359: 2332: 2331: 2330: 2329: 2326: 2320: 2311: 2310: 2309: 2306: 2303: 2300: 2288: 2287: 2286: 2280: 2267: 2259:Main article: 2256: 2253: 2239: 2237: 2236: 2234: 2232: 2230: 2228: 2221: 2219: 2217: 2215: 2213: 2211: 2204: 2202: 2200: 2198: 2196: 2194: 2192: 2189: 2188: 2186: 2184: 2182: 2180: 2178: 2176: 2174: 2172: 2170: 2167: 2166: 2164: 2162: 2160: 2158: 2156: 2154: 2152: 2150: 2148: 2146: 2144: 2142: 2140: 2138: 2136: 2134: 2132: 2130: 2128: 2126: 2124: 2122: 2120: 2118: 2115: 2113: 2112: 2106: 2104: 2102: 2100: 2098: 2096: 2090: 2088: 2086: 2084: 2082: 2080: 2074: 2072: 2070: 2067: 2066: 2064: 2062: 2060: 2058: 2056: 2054: 2052: 2050: 2048: 2046: 2044: 2042: 2040: 2038: 2036: 2034: 2032: 2030: 2027: 2026: 2024: 2022: 2020: 2018: 2016: 2014: 2012: 2010: 2008: 2006: 2004: 2002: 2000: 1998: 1996: 1994: 1992: 1990: 1988: 1986: 1984: 1982: 1980: 1978: 1975: 1973: 1972: 1970: 1968: 1966: 1964: 1962: 1960: 1958: 1956: 1953: 1951: 1949: 1947: 1945: 1943: 1941: 1939: 1937: 1935: 1933: 1914: 1905: 1903: 1902: 1900: 1898: 1896: 1894: 1888: 1886: 1884: 1878: 1876: 1869: 1868: 1866: 1864: 1862: 1860: 1858: 1856: 1854: 1852: 1850: 1848: 1846: 1844: 1841: 1840: 1838: 1836: 1834: 1832: 1830: 1828: 1826: 1824: 1822: 1820: 1818: 1816: 1814: 1812: 1810: 1808: 1806: 1804: 1802: 1799: 1797: 1796: 1794: 1787: 1785: 1782: 1780: 1777: 1774: 1773: 1771: 1769: 1767: 1765: 1763: 1761: 1759: 1757: 1755: 1753: 1750: 1749: 1747: 1745: 1743: 1741: 1739: 1737: 1735: 1733: 1731: 1729: 1727: 1725: 1723: 1721: 1719: 1717: 1715: 1713: 1710: 1708: 1707: 1705: 1703: 1701: 1695: 1693: 1691: 1689: 1683: 1681: 1679: 1677: 1675: 1672: 1671: 1669: 1667: 1665: 1663: 1661: 1659: 1657: 1654: 1653: 1651: 1649: 1647: 1645: 1643: 1641: 1639: 1637: 1635: 1633: 1631: 1629: 1627: 1625: 1623: 1621: 1619: 1617: 1615: 1612: 1610: 1609: 1607: 1605: 1603: 1601: 1599: 1597: 1594: 1592: 1590: 1588: 1586: 1584: 1582: 1580: 1562: 1559: 1555:B12 deficiency 1529: 1526: 1511:renal function 1497:, serum iron, 1488:erythropoiesis 1461: 1452:serum ferritin 1445: 1444: 1441: 1438: 1434: 1433: 1430: 1427: 1423: 1422: 1419: 1416: 1412: 1411: 1408: 1405: 1401: 1400: 1397: 1394: 1390: 1389: 1386: 1383: 1379: 1378: 1375: 1372: 1352:flow cytometry 1335: 1332: 1283: 1280: 1259: 1256: 1255: 1254: 1248: 1241:celiac disease 1237: 1219: 1216: 1215: 1214: 1211: 1203: 1202:Fluid overload 1200: 1165: 1164: 1158: 1142: 1131: 1121: 1118: 1115:angiodysplasia 1103: 1093: 1085: 1082: 1081: 1080: 1079: 1078: 1077: 1076: 1075:induced anemia 1061: 1060: 1059: 1054: 1049: 1043: 1027: 1026: 1025: 1016: 1007: 1001: 967: 966: 965: 960: 959: 958: 955: 945: 944: 943: 930: 914: 908: 902: 854: 851: 850: 849: 848: 847: 840: 834: 829: 816: 815: 814: 811: 805: 799: 796: 786: 779: 772: 768: 763: 755: 737: 736: 735: 729: 727:erythropoietin 720:kidney failure 716: 713:Fanconi anemia 702: 692: 689: 668: 665: 630:bounding pulse 612:major) or leg 605: 536:cardiac output 428: 425: 349:, and certain 324: 311:blood donation 207:blood disorder 190: 189: 186: 182: 181: 176: 170: 169: 163: 159: 158: 144: 138: 137: 132: 126: 125: 123: 122: 87: 85: 81: 80: 66: 65: 57: 56: 53: 49: 48: 40: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 8819: 8808: 8805: 8803: 8800: 8798: 8795: 8794: 8792: 8777: 8769: 8767: 8763: 8759: 8757: 8749: 8747: 8739: 8737: 8729: 8728: 8725: 8719: 8716: 8712: 8709: 8708: 8707: 8704: 8702: 8699: 8697: 8694: 8692: 8689: 8687: 8684: 8682: 8681:Public health 8679: 8677: 8674: 8672: 8669: 8667: 8664: 8662: 8661:Allied health 8659: 8657: 8654: 8653: 8651: 8647: 8639: 8636: 8635: 8634: 8631: 8629: 8626: 8624: 8621: 8619: 8616: 8614: 8611: 8609: 8606: 8604: 8601: 8599: 8596: 8595: 8593: 8591: 8585: 8573: 8570: 8569: 8568: 8565: 8563: 8560: 8558: 8555: 8553: 8550: 8546: 8543: 8542: 8541: 8538: 8536: 8533: 8531: 8528: 8524: 8521: 8520: 8519: 8516: 8514: 8511: 8509: 8506: 8503: 8500: 8498: 8495: 8491: 8488: 8487: 8486: 8483: 8481: 8478: 8476: 8473: 8471: 8470:Oral medicine 8468: 8466: 8465:Ophthalmology 8463: 8461: 8458: 8454: 8451: 8450: 8449: 8446: 8444: 8441: 8439: 8436: 8434: 8431: 8429: 8426: 8424: 8420: 8417: 8415: 8412: 8408: 8405: 8404: 8403: 8400: 8398: 8395: 8393: 8390: 8388: 8385: 8383: 8380: 8376: 8373: 8371: 8368: 8367: 8366: 8363: 8361: 8358: 8356: 8353: 8352: 8350: 8346: 8338: 8335: 8333: 8330: 8328: 8327:Cytopathology 8325: 8323: 8320: 8318: 8315: 8313: 8310: 8309: 8308: 8305: 8301: 8298: 8296: 8293: 8291: 8288: 8287: 8286: 8283: 8282: 8280: 8278: 8274: 8268: 8267:Urogynecology 8265: 8263: 8260: 8258: 8255: 8253: 8250: 8248: 8245: 8243: 8240: 8239: 8237: 8235: 8229: 8223: 8220: 8218: 8215: 8213: 8210: 8208: 8205: 8203: 8200: 8198: 8195: 8193: 8190: 8188: 8185: 8181: 8178: 8177: 8176: 8173: 8171: 8170:Endocrinology 8168: 8166: 8163: 8161: 8158: 8156: 8152: 8149: 8148: 8146: 8144: 8138: 8132: 8129: 8125: 8122: 8121: 8120: 8117: 8115: 8112: 8110: 8107: 8105: 8102: 8100: 8097: 8095: 8092: 8090: 8087: 8080: 8079: 8078: 8075: 8073: 8070: 8068: 8065: 8063: 8060: 8058: 8055: 8051: 8048: 8046: 8043: 8042: 8041: 8038: 8036: 8033: 8031: 8028: 8026: 8023: 8021: 8018: 8017: 8015: 8013: 8009: 8006: 8004: 7998: 7994: 7990: 7983: 7978: 7976: 7971: 7969: 7964: 7963: 7960: 7944: 7941: 7939: 7936: 7934: 7931: 7929: 7926: 7925: 7923: 7919: 7907: 7904: 7902: 7899: 7898: 7897: 7896: 7892: 7888: 7885: 7883: 7880: 7878: 7875: 7874: 7873: 7872: 7868: 7867: 7865: 7863: 7859: 7853: 7852:Myelophthisic 7850: 7848: 7845: 7843: 7839: 7838: 7836: 7833: 7831: 7827: 7824: 7822: 7819: 7814: 7810: 7800: 7797: 7796: 7793: 7790: 7788: 7785: 7784: 7779: 7776: 7775: 7774: 7771: 7769: 7766: 7765: 7760: 7757: 7756: 7755: 7754: 7750: 7749: 7740: 7737: 7733: 7730: 7729: 7728: 7725: 7723: 7720: 7718: 7715: 7714: 7712: 7710: 7706: 7703: 7701: 7697: 7691: 7688: 7684: 7681: 7680: 7679: 7676: 7672: 7669: 7668: 7667: 7664: 7662: 7658: 7656: 7653: 7651: 7647: 7644: 7640: 7637: 7635: 7632: 7630: 7627: 7626: 7625: 7622: 7620: 7616: 7615: 7610: 7607: 7605: 7602: 7600: 7597: 7596: 7595: 7594: 7590: 7588: 7585: 7583: 7579: 7578: 7576: 7574: 7570: 7567: 7564: 7559: 7555: 7547: 7544: 7543: 7542: 7538: 7535: 7534: 7529: 7526: 7525: 7524: 7520: 7517: 7516: 7514: 7512: 7508: 7505: 7503: 7499: 7496: 7492: 7482: 7479: 7478: 7476: 7474: 7470: 7467: 7463: 7459: 7455: 7448: 7443: 7441: 7436: 7434: 7429: 7428: 7425: 7412: 7409: 7406: 7402: 7401: 7397: 7395: 7391: 7390: 7386: 7385: 7382: 7378: 7371: 7367: 7366: 7362: 7360: 7356: 7355: 7351: 7349: 7345: 7344: 7340: 7338: 7334: 7330: 7329: 7325: 7321: 7319: 7315: 7311: 7310: 7306: 7302: 7301: 7298: 7293: 7289: 7283: 7280: 7278: 7275: 7274: 7270: 7261: 7257: 7253: 7249: 7245: 7241: 7234: 7231: 7226: 7222: 7217: 7212: 7207: 7202: 7198: 7194: 7190: 7183: 7180: 7175: 7171: 7167: 7163: 7159: 7155: 7151: 7147: 7140: 7137: 7132: 7128: 7123: 7118: 7114: 7110: 7106: 7099: 7096: 7091: 7087: 7083: 7079: 7074: 7069: 7065: 7061: 7057: 7050: 7047: 7042: 7038: 7033: 7028: 7024: 7020: 7016: 7012: 7008: 7001: 6999: 6995: 6990: 6984: 6976: 6972: 6968: 6964: 6960: 6953: 6950: 6945: 6939: 6923: 6919: 6915: 6908: 6905: 6892: 6888: 6881: 6879: 6877: 6873: 6868: 6864: 6859: 6854: 6850: 6846: 6842: 6838: 6834: 6827: 6824: 6809: 6805: 6801: 6800: 6791: 6787: 6781: 6778: 6773: 6769: 6765: 6761: 6757: 6750: 6748: 6744: 6731: 6727: 6721: 6719: 6715: 6710: 6706: 6702: 6698: 6694: 6687: 6685: 6683: 6679: 6674: 6670: 6666: 6660: 6656: 6655: 6647: 6644: 6632: 6628: 6622: 6619: 6614: 6610: 6605: 6600: 6596: 6592: 6588: 6584: 6580: 6573: 6570: 6565: 6561: 6556: 6551: 6547: 6543: 6539: 6532: 6529: 6524: 6520: 6516: 6512: 6508: 6504: 6500: 6496: 6489: 6487: 6483: 6478: 6474: 6469: 6464: 6460: 6456: 6452: 6445: 6442: 6437: 6433: 6428: 6423: 6419: 6415: 6411: 6407: 6403: 6396: 6393: 6380: 6376: 6370: 6367: 6362: 6358: 6354: 6350: 6346: 6342: 6335: 6332: 6327: 6323: 6318: 6313: 6309: 6305: 6301: 6297: 6293: 6286: 6283: 6278: 6274: 6269: 6264: 6260: 6256: 6252: 6245: 6242: 6237: 6231: 6227: 6226: 6218: 6215: 6210: 6204: 6200: 6199: 6191: 6188: 6183: 6181:9780702036255 6177: 6173: 6172: 6164: 6161: 6156: 6152: 6147: 6142: 6138: 6134: 6130: 6123: 6121: 6117: 6112: 6108: 6103: 6098: 6094: 6090: 6086: 6082: 6078: 6071: 6068: 6063: 6059: 6055: 6051: 6047: 6043: 6039: 6035: 6028: 6025: 6012: 6008: 6002: 5999: 5986: 5982: 5976: 5973: 5968: 5964: 5959: 5954: 5950: 5946: 5942: 5935: 5932: 5927: 5921: 5917: 5913: 5909: 5902: 5899: 5894: 5888: 5884: 5877: 5874: 5869: 5863: 5859: 5852: 5850: 5846: 5833: 5829: 5823: 5820: 5816: 5812: 5808: 5803: 5800: 5795: 5791: 5787: 5783: 5779: 5775: 5768: 5765: 5760: 5756: 5752: 5748: 5745:(7808): 882. 5744: 5740: 5733: 5730: 5714: 5707: 5701: 5698: 5693: 5689: 5684: 5679: 5675: 5671: 5667: 5660: 5657: 5652: 5648: 5644: 5640: 5636: 5632: 5628: 5624: 5617: 5614: 5602: 5598: 5592: 5589: 5576: 5572: 5568: 5564: 5560: 5556: 5549: 5546: 5542: 5538: 5535: 5530: 5527: 5522: 5518: 5514: 5508: 5504: 5500: 5496: 5489: 5486: 5474: 5470: 5464: 5461: 5449: 5445: 5439: 5436: 5424: 5420: 5414: 5411: 5395: 5391: 5385: 5378: 5377: 5369: 5366: 5360: 5355: 5351: 5344: 5342: 5338: 5333: 5329: 5323: 5319: 5318: 5310: 5307: 5302: 5298: 5292: 5288: 5287: 5279: 5276: 5271: 5265: 5261: 5254: 5251: 5246: 5242: 5236: 5232: 5231: 5223: 5220: 5217: 5213: 5212: 5206: 5203: 5198: 5194: 5189: 5184: 5180: 5176: 5172: 5168: 5164: 5157: 5154: 5149: 5145: 5140: 5135: 5131: 5127: 5123: 5116: 5113: 5108: 5104: 5099: 5094: 5090: 5086: 5082: 5075: 5072: 5067: 5063: 5059: 5055: 5051: 5047: 5040: 5037: 5032: 5028: 5023: 5018: 5013: 5008: 5004: 5000: 4996: 4988: 4985: 4980: 4976: 4971: 4966: 4961: 4956: 4952: 4948: 4944: 4937: 4935: 4931: 4926: 4922: 4918: 4914: 4910: 4906: 4902: 4898: 4891: 4889: 4885: 4880: 4876: 4871: 4866: 4861: 4856: 4852: 4848: 4844: 4837: 4834: 4829: 4825: 4820: 4815: 4811: 4807: 4803: 4799: 4795: 4788: 4785: 4773: 4769: 4763: 4760: 4755: 4749: 4745: 4738: 4735: 4730: 4726: 4721: 4716: 4712: 4708: 4704: 4700: 4696: 4689: 4686: 4681: 4677: 4673: 4669: 4665: 4661: 4654: 4651: 4646: 4642: 4638: 4634: 4630: 4626: 4622: 4618: 4611: 4608: 4603: 4599: 4594: 4589: 4584: 4579: 4575: 4571: 4570:Critical Care 4567: 4560: 4557: 4552: 4548: 4544: 4540: 4536: 4532: 4528: 4524: 4517: 4514: 4509: 4505: 4500: 4495: 4490: 4485: 4481: 4477: 4473: 4466: 4463: 4458: 4452: 4449: 4444: 4440: 4436: 4432: 4428: 4424: 4417: 4414: 4409: 4405: 4400: 4395: 4391: 4387: 4383: 4379: 4375: 4368: 4365: 4362: 4358: 4354: 4349: 4346: 4341: 4335: 4331: 4324: 4321: 4316: 4310: 4306: 4299: 4296: 4291: 4285: 4277: 4273: 4269: 4263: 4259: 4252: 4249: 4236: 4232: 4225: 4222: 4209: 4205: 4201: 4195: 4192: 4187: 4180: 4177: 4172: 4166: 4162: 4154: 4152: 4150: 4148: 4146: 4144: 4142: 4140: 4138: 4136: 4134: 4132: 4130: 4128: 4126: 4124: 4122: 4120: 4118: 4116: 4114: 4112: 4110: 4108: 4106: 4104: 4102: 4098: 4093: 4089: 4083: 4080: 4075: 4071: 4067: 4063: 4058: 4053: 4049: 4045: 4041: 4034: 4031: 4019: 4015: 4009: 4006: 4001: 3999:9781451154542 3995: 3991: 3990: 3982: 3979: 3974: 3970: 3966: 3962: 3958: 3954: 3947: 3944: 3939: 3935: 3930: 3925: 3921: 3917: 3913: 3906: 3903: 3898: 3894: 3890: 3886: 3882: 3878: 3871: 3868: 3863: 3859: 3854: 3849: 3845: 3841: 3837: 3833: 3829: 3822: 3819: 3807: 3803: 3797: 3794: 3781: 3777: 3771: 3769: 3767: 3765: 3761: 3756: 3752: 3747: 3742: 3737: 3732: 3728: 3724: 3720: 3713: 3710: 3698: 3694: 3688: 3685: 3681: 3677: 3674: 3669: 3667: 3663: 3658: 3652: 3649: 3644: 3640: 3636: 3630: 3627: 3615: 3611: 3605: 3602: 3597: 3593: 3588: 3583: 3579: 3575: 3571: 3567: 3563: 3556: 3553: 3548: 3544: 3539: 3534: 3530: 3526: 3522: 3518: 3514: 3507: 3505: 3503: 3501: 3499: 3495: 3482: 3481:GlobeNewswire 3478: 3472: 3470: 3468: 3464: 3459: 3455: 3450: 3445: 3441: 3437: 3433: 3426: 3423: 3418: 3414: 3410: 3406: 3402: 3398: 3394: 3390: 3383: 3381: 3379: 3375: 3370: 3366: 3362: 3358: 3354: 3350: 3346: 3342: 3334: 3331: 3326: 3322: 3318: 3317: 3309: 3306: 3301: 3297: 3293: 3286: 3283: 3271: 3267: 3261: 3258: 3245: 3241: 3237: 3231: 3228: 3216: 3212: 3206: 3204: 3200: 3187: 3181: 3178: 3173: 3169: 3164: 3159: 3155: 3151: 3147: 3143: 3139: 3132: 3130: 3126: 3121: 3117: 3113: 3109: 3105: 3098: 3096: 3094: 3092: 3090: 3088: 3086: 3084: 3082: 3080: 3078: 3076: 3074: 3072: 3070: 3068: 3066: 3064: 3062: 3060: 3058: 3056: 3054: 3052: 3050: 3046: 3039: 3037: 3028: 3019: 3015: 3012:This section 3010: 3007: 3003: 3002: 2996: 2994: 2987: 2985: 2978: 2976: 2974: 2970: 2966: 2965:blood product 2962: 2958: 2954: 2950: 2946: 2943:(HBO) by the 2942: 2934: 2932: 2929: 2925: 2917: 2915: 2913: 2899: 2889: 2873: 2871: 2870:transfusion. 2867: 2864: 2856: 2854: 2852: 2848: 2843: 2835: 2833: 2831: 2827: 2823: 2820: 2815: 2813: 2809: 2805: 2801: 2796: 2789: 2787: 2783: 2781: 2770: 2766: 2762: 2758: 2749: 2747: 2745: 2741: 2740:iron overload 2737: 2729: 2727: 2725: 2721: 2717: 2709: 2707: 2705: 2697: 2692: 2688: 2684: 2681: 2677: 2673: 2669: 2666: 2662: 2661: 2656: 2652: 2651: 2650: 2648: 2647:acetaminophen 2644: 2637: 2635: 2631: 2624: 2619: 2616: 2613: 2610: 2608: 2605: 2603: 2599: 2598: 2596: 2594: 2588: 2580: 2578: 2576: 2572: 2565: 2561: 2557: 2549: 2545: 2541: 2529: 2525: 2521: 2517: 2513: 2510: 2509:liver disease 2506: 2502: 2499: 2497: 2494: 2485: 2481: 2474: 2470: 2462: 2458: 2455: 2454: 2448: 2440: 2436: 2429: 2426: 2425: 2423: 2415: 2413: 2411: 2410:Mentzer index 2403: 2399: 2395: 2391: 2387: 2384: 2380: 2376: 2372: 2368: 2364: 2360: 2357: 2352: 2348: 2343: 2339: 2338: 2337: 2327: 2325: 2324:lead toxicity 2321: 2318: 2317: 2315: 2314:Sideroblastic 2312: 2307: 2304: 2301: 2299: 2295: 2294: 2292: 2289: 2284: 2281: 2278: 2275: 2274: 2272: 2269: 2268: 2266: 2262: 2254: 2252: 2250: 2246: 2238: 2226: 2209: 2190: 2187: 2171: 2169: 2168: 2153: 2145: 2143: 2135: 2133: 2116: 2114: 2110: 2094: 2078: 2068: 2065: 2049: 2047: 2031: 2029: 2028: 2021: 2005: 2003: 1987: 1985: 1976: 1974: 1931: 1928: 1926: 1922: 1918: 1911: 1904: 1892: 1882: 1874: 1870: 1867: 1857: 1855: 1849: 1847: 1845: 1843: 1842: 1827: 1817: 1815: 1809: 1807: 1805: 1803: 1800: 1798: 1792: 1775: 1772: 1764: 1762: 1754: 1752: 1751: 1736: 1728: 1726: 1718: 1716: 1711: 1709: 1699: 1687: 1673: 1670: 1658: 1656: 1655: 1642: 1636: 1634: 1628: 1626: 1613: 1611: 1578: 1575: 1573: 1569: 1560: 1558: 1556: 1552: 1548: 1544: 1540: 1536: 1527: 1525: 1523: 1518: 1516: 1512: 1508: 1504: 1500: 1496: 1491: 1489: 1484: 1480: 1476: 1470: 1469:, if needed. 1468: 1464: 1457: 1453: 1442: 1439: 1436: 1435: 1431: 1428: 1425: 1424: 1420: 1417: 1414: 1413: 1409: 1406: 1403: 1402: 1398: 1395: 1392: 1391: 1387: 1384: 1381: 1380: 1376: 1373: 1370: 1369: 1363: 1361: 1357: 1353: 1349: 1345: 1341: 1333: 1331: 1327: 1324: 1320: 1315: 1313: 1309: 1305: 1301: 1297: 1293: 1289: 1281: 1275: 1269: 1264: 1257: 1252: 1249: 1246: 1242: 1238: 1235: 1234: 1230: 1229: 1228: 1226: 1217: 1212: 1209: 1208: 1207: 1201: 1199: 1197: 1193: 1189: 1186: 1182: 1178: 1174: 1170: 1162: 1159: 1157: 1156: 1151: 1147: 1143: 1140: 1136: 1132: 1130: 1126: 1122: 1119: 1116: 1112: 1108: 1107:peptic ulcers 1104: 1101: 1097: 1094: 1091: 1088: 1087: 1083: 1074: 1070: 1069: 1065: 1064: 1062: 1058: 1057:Haemodialysis 1055: 1053: 1052:Heart surgery 1050: 1048: 1044: 1042: 1038: 1034: 1031: 1030: 1028: 1024: 1020: 1017: 1015: 1011: 1008: 1005: 1002: 999: 995: 991: 987: 984: 980: 977: 976: 974: 971: 970: 968: 964: 961: 956: 954: 951: 950: 949: 946: 942: 938: 934: 931: 929: 925: 921: 918: 917: 915: 912: 909: 906: 903: 900: 896: 893: 892: 890: 886: 882: 881: 880: 878: 874: 870: 866: 860: 852: 845: 841: 839: 835: 833: 830: 827: 826:myelophthisis 823: 820: 819: 817: 812: 809: 806: 803: 800: 797: 794: 790: 787: 785: 777: 773: 766: 759: 751: 748:is a form of 747: 744: 743: 742: 741:erythroblasts 738: 734: 730: 728: 725: 721: 717: 714: 710: 706: 703: 701: 698: 697: 695: 694: 690: 688: 686: 682: 673: 666: 664: 662: 658: 654: 650: 646: 645:heart failure 642: 639: 635: 631: 627: 623: 619: 615: 611: 603: 599: 595: 591: 587: 584: 580: 576: 572: 568: 564: 559: 557: 556:heart failure 553: 549: 548:heart disease 545: 541: 537: 532: 530: 526: 525:feeling faint 521: 519: 515: 514:poor appetite 511: 507: 503: 499: 495: 491: 488:, headaches, 487: 478: 474: 473:AIIMS Kalyani 470: 465: 461: 459: 455: 451: 450:feeling tired 441: 433: 426: 424: 422: 418: 414: 410: 404: 402: 397: 395: 390: 386: 382: 377: 375: 371: 367: 363: 359: 354: 352: 348: 344: 340: 336: 332: 328: 320: 316: 312: 308: 304: 300: 296: 292: 287: 285: 281: 277: 273: 269: 265: 261: 257: 253: 249: 245: 241: 238: 234: 231: 230:Ancient Greek 226: 224: 220: 216: 212: 209:in which the 208: 204: 200: 196: 187: 183: 180: 177: 175: 171: 167: 164: 160: 156: 152: 148: 147:Feeling tired 145: 143: 139: 136: 133: 131: 127: 118: 89: 88: 86: 84:Pronunciation 82: 79: 75: 71: 67: 63: 58: 54: 50: 45: 39: 35: 30: 19: 8686:Rural health 8671:Nanomedicine 8222:Rheumatology 8153: / 8072:Hand surgery 8057:Neurosurgery 7901:normochromic 7893: 7869: 7751: 7659: 7617: 7591: 7580: 7501: 7473:Polycythemia 7398: 7387: 7363: 7352: 7341: 7322: 7303: 7246:(1): 11–27. 7243: 7239: 7233: 7199:(18): 6976. 7196: 7192: 7182: 7152:(6): 690–5. 7149: 7145: 7139: 7112: 7108: 7098: 7063: 7059: 7049: 7014: 7010: 6983:cite journal 6969:(1): 61–83. 6966: 6962: 6952: 6938:cite journal 6926:. Retrieved 6921: 6917: 6907: 6895:. Retrieved 6891:the original 6840: 6836: 6826: 6815:, retrieved 6796: 6780: 6755: 6734:. Retrieved 6730:the original 6700: 6696: 6653: 6646: 6634:. Retrieved 6630: 6621: 6586: 6582: 6572: 6545: 6541: 6531: 6498: 6494: 6458: 6454: 6444: 6409: 6405: 6395: 6383:. Retrieved 6369: 6344: 6340: 6334: 6299: 6295: 6285: 6258: 6254: 6244: 6224: 6217: 6197: 6190: 6170: 6163: 6136: 6132: 6084: 6080: 6070: 6037: 6033: 6027: 6015:. Retrieved 6001: 5989:. Retrieved 5975: 5948: 5944: 5934: 5907: 5901: 5882: 5876: 5857: 5836:. Retrieved 5822: 5802: 5777: 5773: 5767: 5742: 5738: 5732: 5720:. Retrieved 5713:the original 5700: 5673: 5669: 5659: 5626: 5622: 5616: 5604:. Retrieved 5600: 5591: 5579:. Retrieved 5562: 5558: 5548: 5529: 5494: 5488: 5476:. Retrieved 5472: 5463: 5451:. Retrieved 5447: 5438: 5426:. Retrieved 5422: 5413: 5401:. Retrieved 5375: 5368: 5349: 5316: 5309: 5285: 5278: 5259: 5253: 5229: 5222: 5209: 5205: 5170: 5166: 5156: 5129: 5125: 5115: 5088: 5084: 5074: 5052:(4): S1–S9. 5049: 5045: 5039: 5002: 4998: 4987: 4950: 4946: 4900: 4896: 4850: 4846: 4836: 4801: 4797: 4787: 4775:. Retrieved 4771: 4762: 4743: 4737: 4702: 4698: 4688: 4663: 4659: 4653: 4620: 4616: 4610: 4573: 4569: 4559: 4526: 4522: 4516: 4479: 4475: 4465: 4451: 4426: 4422: 4416: 4381: 4377: 4367: 4348: 4329: 4323: 4304: 4298: 4257: 4251: 4239:. Retrieved 4234: 4224: 4212:. Retrieved 4208:the original 4203: 4194: 4185: 4179: 4160: 4091: 4082: 4047: 4043: 4033: 4021:. Retrieved 4017: 4008: 3988: 3981: 3956: 3952: 3946: 3919: 3915: 3905: 3880: 3876: 3870: 3835: 3831: 3821: 3809:. Retrieved 3805: 3796: 3784:. Retrieved 3779: 3726: 3722: 3712: 3700:. Retrieved 3696: 3687: 3651: 3643:the original 3638: 3629: 3619:February 27, 3617:. Retrieved 3613: 3604: 3569: 3565: 3555: 3520: 3516: 3485:. Retrieved 3480: 3439: 3435: 3425: 3392: 3388: 3344: 3340: 3333: 3315: 3308: 3291: 3285: 3273:. Retrieved 3269: 3260: 3248:. Retrieved 3239: 3230: 3218:. Retrieved 3214: 3190:. Retrieved 3180: 3145: 3141: 3111: 3107: 3035: 3022: 3018:adding to it 3013: 2991: 2988:Epidemiology 2982: 2938: 2921: 2900: 2881: 2868: 2860: 2839: 2826:epoetin alfa 2816: 2797: 2793: 2784: 2771:or vitamin B 2753: 2733: 2713: 2701: 2680:U.S. pennies 2658: 2643:Heinz bodies 2641: 2632: 2628: 2590: 2560:George Minot 2532: 2528:heavy metals 2516:methotrexate 2505:macrocytosis 2407: 2379:colon polyps 2334: 2305:HbC syndrome 2302:HbE syndrome 2264: 2242: 2225:reticulocyte 2208:reticulocyte 2095:(MCV 80–100) 2079:(MCV>100) 1923: 1920: 1912: 1909: 1908: 1875:(MCV>100) 1564: 1531: 1519: 1513:tests (e.g. 1492: 1475:reticulocyte 1471: 1456:iron studies 1448: 1337: 1328: 1316: 1285: 1231: 1221: 1205: 1191: 1187: 1180: 1172: 1168: 1166: 1153: 1125:menstruation 1072: 1066: 1035:, including 862: 802:Thalassemias 681:hypervolemia 678: 634:flow murmurs 582: 565:(pale skin, 560: 552:claudication 540:palpitations 533: 522: 482: 446: 405: 398: 378: 355: 288: 243: 240: 236: 233: 227: 198: 194: 193: 153:, weakness, 38: 29: 8756:Wikiproject 8545:Venereology 8490:Neonatology 8387:Dermatology 8242:Gynaecology 8234:gynaecology 8217:Pulmonology 8035:Eye surgery 7997:Specialties 7906:hypochromic 7862:Blood tests 7624:Thalassemia 7582:enzymopathy 7511:Nutritional 7389:MedlinePlus 6461:: 338–347. 6139:: 398–404. 6087:(1): 8–11. 6017:October 31, 5991:October 31, 5478:October 11, 5453:October 11, 5428:October 11, 5359:10665/85839 4798:Metallomics 4482:(9): e291. 4429:(1): 3–13. 4214:December 2, 3639:www.who.int 3270:Mayo Clinic 3220:February 8, 3192:February 8, 3025:August 2020 2886:is used by 2819:recombinant 2757:thalassemia 2698:Hyperanemia 2298:thalassemia 2249:bone marrow 2111:(MCV<80) 1893:(MCV<80) 1791:bone marrow 1499:transferrin 1479:bone marrow 1356:blood smear 1282:Definitions 1111:hemorrhoids 844:bone marrow 709:blood cells 626:tachycardia 610:thalassemia 596: â€“ in 586:koilonychia 571:conjunctiva 477:West Bengal 331:thalassemia 70:Blood smear 52:Other names 8791:Categories 8518:Psychiatry 8504:(PM&R) 8497:Phlebology 8485:Pediatrics 8312:Anatomical 8277:Diagnostic 8257:Obstetrics 8207:Nephrology 8192:Hematology 8187:Geriatrics 8180:Hepatology 8165:Cardiology 8155:Immunology 7887:macrocytic 7882:microcytic 7877:normocytic 7840:Acquired: 7826:Hereditary 7593:glycolysis 7573:Hereditary 7354:DiseasesDB 6817:August 17, 5838:August 24, 5722:August 24, 5623:Pediatrics 5128:(Review). 5087:(Review). 5001:(Review). 4949:(Review). 4849:(Review). 4800:(Review). 4576:(1): 278. 4378:Hematology 4237:. UpToDate 3877:The Lancet 3811:January 8, 3729:(3): 921. 3702:January 8, 3316:StatPearls 3040:References 2912:neurologic 2769:folic acid 2704:hematocrit 2667:or garlic. 2602:blood loss 2581:Normocytic 2520:zidovudine 2501:Alcoholism 2469:autoimmune 2439:folic acid 2416:Macrocytic 2255:Microcytic 1547:macrocytic 1543:microcytic 1360:microscope 1319:hematocrit 1306:below the 1300:hemoglobin 1236:infection. 1185:widespread 1084:Blood loss 1063:Parasitic 1010:Rh disease 990:idiopathic 983:autoimmune 975:-mediated 928:glycolysis 924:hexokinase 836:anemia of 793:hematocrit 774:Anemia of 758:deficiency 731:Anemia of 718:Anemia of 653:hemoglobin 602:nerve cell 529:chest pain 381:iron pills 327:deficiency 305:, serious 291:blood loss 223:hemoglobin 166:Blood loss 135:Hematology 8706:Physician 8590:education 8448:Neurology 8443:Narcology 8307:Pathology 8285:Radiology 8160:Angiology 8124:Andrology 7558:Hemolytic 7411:emerg/734 7408:emerg/808 7400:eMedicine 7370:271737000 7365:SNOMED CT 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Index

Anemic
Anemia (disambiguation)

Blood smear
iron-deficiency anemia
red blood cells
/əˈniːmiə/
Specialty
Hematology
Symptoms
Feeling tired
pale skin
shortness of breath
Blood loss
Diagnostic method
Blood hemoglobin measurement
British English
blood disorder
blood
oxygen
red blood cells
hemoglobin
Ancient Greek
tiredness
weakness
shortness of breath
headaches
reduced ability to exercise
confusion
feeling like one is going to pass out

Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.

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