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Anil Potti

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211:. The board issued its disciplinary action against Potti but imposed no sanctions. In its consent order, the North Carolina Medical Board stated that the board has no evidence from which it could conclude that Potti received funding for medical research as a result of the inaccuracies that he would not have otherwise received, but concluded that "...Potti's conduct as described herein constitutes unprofessional conduct..." In separate action on Potti's medical license, the North Carolina Medical Board reviewed 11 payments made to settle malpractice claims and posted on its website that "no public action was warranted". Potti was issued a medical license in Missouri on 1 February 2011; on 6 March 2012, the Missouri medical board (known as the Board of Registration for the Healing Arts) issued a reprimand on the basis of actions taken by the North Carolina Medical Board. 279:
recommendations released in March 2012 spoke to the many parties responsible for discovery and development of omics-based tests, including investigators, their institutions, sponsors of research, the FDA, and journals. The report identified best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials. The IOM's recommendations aimed to ensure that progress in omics test development is grounded in sound scientific practice and is reproducible, resulting not only in improved health care but also in continued public trust.
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called for scientific investigators to make the data, computer codes and computational procedures used to develop their clinical tests "publicly accessible for independent review" and to ensure that their data and research steps are presented comprehensibly. The report also found that so-called "omics" tests – such as genomics and proteomics, which are diagnostic tools based on molecular patterns – are in general highly prone to errors. IOM committee chair Gilbert Omenn, a computational biologist at the University of Michigan, said the problems could have been avoided. But he noted, as well, that those kinds of problems were not unique to Duke. "There are a lot of lessons here that surely apply to other places," Omenn said.
378:. Venous thromboembolism (VTE) affects about 3 in 1000 Americans. Out of the three, 10% have aPLAs. This study consisted of 129 patients. Out of those 129, 57 had APS and VTE, 32 had VTE without aPLA, 32 had aPLA, and 8 were healthy. Gene-expression profiles identify and predict individuals with APS from patients with VTE without aPLA. It is important to be able to predict APS and venous thrombosis because it will help with the management of the disease. This article was retracted because the other authors were unable to reproduce the data Potti cited. 204:(USFDA) reviewed one of the studies in 2009, several years after its initiation, and concluded that the study would require an Investigational New Drug application, which had not been submitted. An FDA audit in 2011 further showed that an Investigational Device Exemption application had not been filed, but otherwise found "no significant deficiencies" in Duke's IRB conduct. Potti's medical license record with the North Carolina Medical Board shows eleven settlements, each of at least $ 75,000, for incidents that appear to be related to these trials. 2651: 2593: 38:(ORI) found that Potti had engaged in research misconduct. According to Potti's voluntary settlement agreement with ORI, Potti can continue to perform research with the requirement of supervision until year 2020, while he "neither admits nor denies ORI's findings of research misconduct." As of 2024 Potti, who is employed at the Cancer Center of North Dakota, has had 11 of his research publications retracted, one publication has received an expression of concern, and two others have been corrected. 306:. They also can help predict how a person will respond to treatment and improve prognosis. The authors said they wanted to retract this article because "…we have been unable to reproduce certain key experiments described in the paper regarding validation and use of the colon cancer prognostic signature. This includes the validation performed with dataset E-MEXP-1224, as reported in Fig. 2A, as well as the generation of prognostic scores for colon cancer cell lines, as reported in Fig. 4…" 402:. It is important for cancer patients to receive the most effective treatment while also hopefully having the best quality of life possible. The researchers developed mRNA and microRNA profiles. They tested the mRNA profiles on 133 breast cancer patients. These breast cancer patients had been treated with TFAC chemotherapy treatment. This article was retracted as some of the information used in it derived from the 180:'s report, entitled "Evolution of Translational Omics: Lessons Learned and the Path Forward", was published on 23 March 2012 and made detailed specific recommendations for clinical trials that incorporate "omics". In February 2012, Joseph Nevins stated that it was "abundantly clear" that there was "manipulated data" that could not have occurred by chance. This was confirmed by the 2015 ORI report. 390:. The patients of this study were in stage IB, II, or IIIA of non-small cell lung cancer. Many patients receive surgery, but the risk of relapse is high. Others receive toxic chemotherapy unnecessarily. This study used gene-expressions to evaluate what form of treatment would be best. This article was retracted by the authors because they could not reproduce the results from the article. 348:). The patients had early-stage breast carcinoma. The study's main point was to find if gene expression signatures could refine breast cancer prognosis. This article talks about cancer, genomic technology, and chemotherapy and radiation. This article was retracted because a large part of the article was based on another article that Potti had written and had published in 334:. Gene expression signatures were developed with in vitro drug sensitivity data and Affymetrix microarray data. These were used to help predict response and sensitivity to chemotherapeutic drugs as well as corresponding drugs. This article was retracted after being corrected because many key experiments could not be reproduced. 159:
Duke University became aware of the suspicions of research misconduct by 2008, when a medical student working with Potti and Nevins withdrew his name from the research and submitted a memorandum entitled "Research Concerns" to the administration. The administration denied any misconduct and convinced
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Following questions raised about genomics research that was led by Potti and Nevins at Duke between 2004 and 2010, the National Cancer Institute requested that the Institute of Medicine (IOM) establish a committee to recommend ways to strengthen omics-based test development and evaluation. The IOM's
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In addition to the settlements, two lawsuits also have been filed against Potti, as well as against Duke and other medical personnel there, charging medical negligence among other claims. In his response to the lawsuits, Potti stated that he was "not aware that false or improper data was included in
368:. Usually, platinum-based chemotherapy is used to treat non-small cell lung cancer, but how patients respond is highly variable. This article also talks about predicting how individuals will respond to cisplatin and pemetrexed. This article was retracted because experiments could not be reproduced. 282:
The IOM report further added that "failure by many parties to detect or act on problems with key data and computational methods … led to the inappropriate enrollment of patients in clinical trials, premature launch of companies and retraction of dozens of research papers." The report specifically
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Stevenson, Marvaretta; Mostertz, William; Acharya, Chaitanya; Kim, William; Walters, Kelli; Barry, William; Higgins, Kristin; Tuchman, Sascha A.; Crawford, Jeffrey; Vlahovic, Gordana; Ready, Neal; Onaitis, Mark; Potti, Anil (2009). "Characterizing the Clinical Relevance of an Embryonic Stem Cell
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Hsu DS, Balakumaran BS, Acharya CR, Vlahovic V, Walters KS, Garman K, Anders C, Riedel RF, Lancaster J, Harpole D, Dressman HK, Nevins JR, Febbo PG, Potti A (1 October 2007). "Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced
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on 15 December 2009. The study purportedly found a common gene expression pattern between lung adenocarcinomas and normal human embryonic stem cells that was associated with a shorter survival of patients with the lung cancer. On 21 February 2012, the manuscript was retracted. The retraction
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Stevenson, M.; Mostertz, W.; Acharya, C. R.; Kim, W.; Walters, K.; Barry, W.; Higgins, K.; Tuchman, S. A.; Crawford, J.; Vlahovic, G.; Ready, N.; Onaitis, M.; Potti, A. (2012). "Retraction: Characterizing the Clinical Relevance of an Embryonic Stem Cell Phenotype in Lung Adenocarcinoma".
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statement was signed by all authors and indicated "that clinical information from a data set ... available at the time of the signature development, was incorrect". Further, that statement indicated that "Drs. Anil Potti and Marvaretta Stevenson take full responsibility for this error".
320:. The researchers wanted to confirm their previous studies of gene-expression signatures in predicting the effects of chemotherapeutic drugs. The article was retracted because the validity of the results was beginning to be questioned and because predictions were made off of the 461:). This study, conducted at Duke University from July 2008 until June 2009, investigated age and gender influence on response to cancer by studying the genes of 787 non-small cell lung cancer patients. The article is under review but has not been retracted as of February 2012. 2120:
Acharya, C. R.; Hsu, D. S.; Anders, C. K.; Anguiano, A.; Salter, K. H.; Walters, K. S.; Redman, R. C.; Tuchman, S. A.; Moylan, C. A.; Mukherjee, S.; Barry, W. T.; Dressman, H. K.; Ginsburg, G. S.; Marcom, K. P.; Garman, K. S.; Lyman, G. H.; Nevins, J. R.; Potti, A. (2012).
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Potti, Anil; Mukherjee, Sayan; Petersen, Rebecca; Dressman, Holly K.; Bild, Andrea; Koontz, Jason; Kratzke, Robert; Watson, Mark A.; Kelley, Michael; Ginsburg, Geoffrey S.; West, Mike; Harpole, David H.; Nevins, Joseph R. (10 August 2006).
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Acharya, CR; Hsu, DS; Anders, CK; Anguiano, A; Salter, KH; Walters, KS; Redman, RC; Tuchman, SA; Moylan, CA (2 April 2008). "Gene expression signatures, clinicopathological features, and individualized therapy in breast cancer".
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Potti resigned from Duke in 2010, following the discovery of flaws in the genomics research conducted at Duke and allegations of embellishments in his resume, assuming responsibility for the anomalies in the scientific research.
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stopped payments of a five-year grant which totaled $ 729,000 as Potti had received the grant based on his credentials. Duke University later reimbursed the American Cancer Society for the full amount of the grant.
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in February 2007. The research studied ovarian cancer patient responses to platinum-based therapy. This marks the latest in a series of about 13 expected Potti retractions, with another 13 expected partial
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Mostertz, W; Stevenson, M; Acharya, C; Chan, I; Walters, K; Lamlertthon, W; Barry, W; Crawford, J; Nevins, J (10 February 2010). "Age- and Sex-Specific Genomic Profiles in Non-Small Cell Lung Cancer".
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Mostertz, W; Stevenson, M; Acharya, C; Chan, I; Walters, K; Lamlertthon, W; Barry, W; Crawford, J; Nevins, J (10 February 2010). "Age- and sex-specific genomic profiles in non-small cell lung cancer".
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Salter, Kelly H.; Acharya, Chaitanya R.; Walters, Kelli S.; Redman, Richard; Anguiano, Ariel; Garman, Katherine S.; Anders, Carey K.; Mukherjee, Sayan; Dressman, Holly K. (2011). Ouchi, Toru (ed.).
270:, provider of the WordPress webhost service that hosts Retraction Watch, filed suit against the filer of the takedown notice, saying that he had made those false claims in violation of the DMCA. 2997: 120:
that he had been a "Rhodes Scholar (Australian Board)". He said he was referring to the Association of Rhodes Scholars in Australia Scholarships, an award granted by an organisation of former
1377: 1718: 440:, this paper was retracted in 2012 with the retraction notice stating, "The authors relied on the results reported by Potti, and they were not aware of the errors subsequently reported." 2849:"Notice of Retraction: Upregulated Oncogenic Pathways in Patients Exposed to Tobacco Smoke May Provide a Novel Approach to Lung Cancer Chemoprevention (Chest. 2008;134:158001S)". 1569: 1462: 1282: 2583: 1341: 1268: 2513:
Salter KH, Acharya CR, Walters KS, Redman R, Anguiano A, Garman KS, Anders CK, Mukherjee S, Dressman HK, Barry WT, Marcom KP, Olson J, Nevins JR, Potti A (2 April 2008).
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Bonnefoi, Hervé; Potti, Anil; Delorenzi, Mauro; Mauriac, Louis; Campone, Mario; Tubiana-Hulin, Michèle; Petit, Thierry; Rouanet, Philippe; Jassem, Jacek (December 2007).
897: 2992: 1978:"Retraction validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: a substudy of the EORTC 10994/BIG 00-01 clinical trial" 1912:"RETRACTED: Validation of gene signatures that predict the response of breast cancer to neoadjuvant chemotherapy: A substudy of the EORTC 10994/BIG 00-01 clinical trial" 2229:"Retraction. Pharmacogenomic strategies provide a rational approach to the treatment of cisplatin-resistant patients with advanced cancer. J Clin Oncol 25:4350–7, 2007" 2499: 1434: 266:
blog posts critical of Potti and the posts were removed. Retraction Watch alleges that these DMCA take-down notices were based on false claims. In November 2013,
93:. He resigned in November 2010 after Duke put him on administrative leave, terminated the clinical trials based on his research and retracted his published data. 1976:
Bonnefoi, Hervé; Potti, Anil; Delorenzi, Mauro; Mauriac, Louis; Campone, Mario; Tubiana-Hulin, Michèle; Petit, Thierry; Rouanet, Philippe; Jassem, Jacek (2011).
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Potti A, Mukherjee S, Petersen R, Dressman HK, Bild A, Koontz J, Kratzke R, Watson MA, Kelley M, Ginsburg GS, West M, Harpole DH Jr, Nevins JR (24 March 2011).
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Potti, Anil; Dressman, Holly K; Bild, Andrea; Riedel, Richard F; Chan, Gina; Sayer, Robyn; Cragun, Janiel; Cottrill, Hope; Kelley, Michael J (January 2011).
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reported this as "The fallout from the Duke case includes 27 papers that Duke expects to be partially or completely retracted". As of February 2012, ten
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based on Potti's research came under scrutiny in 2009 and were temporarily suspended, then were permanently stopped in 2010. The United States
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of Duke testified that they had looked at 40 of Potti's publications and that two-thirds of them would be retracted in whole or in part.
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Garman, K. S.; Acharya, C. R.; Edelman, E.; Grade, M.; Gaedcke, J.; Sud, S.; Barry, W.; Diehl, A. M.; Provenzale, D. (2 December 2008).
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As of 2018, 11 papers co-authored by Potti have been retracted, and seven others have been corrected. Potti's retracted papers are:
47: 2967: 951: 585: 431:"Upregulated Oncogenic Pathways in Patients Exposed to Tobacco Smoke May Provide a Novel Approach to Lung Cancer Chemoprevention" 386: 161: 140: 359:"Pharmacogenomic Strategies Provide a Rational Approach to the Treatment of Cisplatin-Resistant Patients with Advanced Cancer" 1499: 197: 2460:"Retraction: A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer. N Engl J Med 2006;355:570–80" 492: 1751: 128: 2982: 1417: 364: 201: 82: 35: 2686:
Dressman, H.K.; Berchuck, A.; Chan, G.; Zhai, J.; Bild, A.; Sayer, R.; Craygun, J.; Clarke, J.; Whitaker, R.S. (2007).
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article which had been retracted. As that article had been retracted, it was felt that this article should be, as well.
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Healthcare companies cut ties with Potti after evidence surfaced that Potti had fabricated awards on his resume. The
1169: 898:"Potti letter addresses scandal: Former researcher calls Rhodes controversy a misunderstanding | The Chronicle" 683: 2977: 2957: 2608:"Retraction: An Integrated Approach to the Prediction of Chemotherapeutic Response in Patients with Breast Cancer" 1109: 769: 2797: 2688:"An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer" 1894: 915: 626: 409:"An Integrated Genomic-Based Approach to Individualized Treatment of Patients With Advanced-Stage Ovarian Cancer" 218:, which was approved in April 2011. Potti was employed as a practicing physician at the Coastal Cancer Center in 136: 109: 1828:"A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities" 1342:"Anil Potti reprimanded by North Carolina state medical board, as lawsuit settlements surface "Retraction Watch" 846: 648: 295:"A Genomic Approach to Colon Cancer Risk Stratification Yields Biologic Insights into Therapeutic Opportunities" 2624: 2571: 875: 73:
Following his resignation from Duke, Potti worked as an oncologist in South Carolina, but was let go in 2012.
1671: 189: 112:, 2010 brought further and more widespread scrutiny when it was discovered by Paul Goldberg and reported in 2650: 2592: 2952: 1236: 2493: 2442: 2212: 1746: 1744: 1742: 1740: 1738: 1736: 977: 248: 219: 177: 173: 86: 337:"Gene Expression Signatures, Clinicopathological Features, and Individualized Therapy in Breast Cancer" 2515:"An Integrated Approach to the Prediction of Chemotherapeutic Response in Patients with Breast Cancer" 393:"An Integrated Approach to the Prediction of Chemotherapeutic Response in Patients with Breast Cancer" 309:"Validation of Gene Signatures that Predict the Response of Breast Cancer to Neoadjuvant Chemotherapy" 2947: 2528: 2122: 1839: 1200: 259: 1514:"Updated: Anil Potti out at Coastal Cancer Center; practice blames Duke for glowing recommendations" 1144: 744: 703: 701: 521: 101: 788: 420:"Characterizing the Clinical Relevance of an Embryonic Stem Cell Phenotype in Lung Adenocarcinoma" 2923: 1808: 1719:"Wordpress Goes Legal: Sues Over Two Egregiously Bogus DMCA Notices That Were Designed To Censor" 1125: 1435:"Troubles continue for former Duke oncologist (Charleston Post and Courier, 23 February, 20120)" 100:
genetic analysis for personalised cancer treatment, which was published in various prestigious
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Evolution of Translational Omics: Lessons Learned and the Path Forward – Institute of Medicine
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In late 2011, the North Carolina Medical Board reprimanded Potti but he retains his
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Potti, A; Bild, A; Dressman, HK; Lewis, DA; Nevins, JR; Ortel, TL (February 2006).
1636:"Anil Potti and colleagues retract ninth paper, this one in JCO " Retraction Watch" 493:"60 Minutes to delve into Potti case (Triangle Business Journal, February 10, 2012" 303: 27: 2827: 2785: 2766: 2394:"A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer" 381:"A Genomic Strategy to Refine Prognosis in Early-Stage Non–Small-Cell Lung Cancer" 2541: 2359: 2314: 1770:"Anil Potti resurfaces with job at North Dakota cancer center – Retraction Watch" 124:
to bring Commonwealth citizens who attend overseas institutions in to Australia.
1697: 1650:"Tenth Potti retraction appears, in Clinical Cancer Research " Retraction Watch" 847:"Duke scientist Anil Potti's different CVs: version 1, version 2, and version 3" 50:, Vellore, India in 1995. He finished an internship in Internal Medicine at the 2342:
Potti A, Bild A, Dressman HK, Lewis DA, Nevins JR, Ortel TL (20 October 2011).
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Proceedings of the National Academy of Sciences of the United States of America
1110:"Lapses in oversight compromise omics results : Nature News & Comment" 1121: 832: 267: 147: 55: 2724: 2704: 2687: 2245: 2228: 2200: 2181: 2073: 1418:"Potti reprimanded by Missouri medical board (The Chronicle, March 12, 2012)" 1882: 1852: 600: 255: 2919: 2835: 2793: 2774: 2732: 2713: 2643: 2579: 2560: 2485: 2438: 2419: 2377: 2322: 2303: 2270:"Gene-expression patterns predict phenotypes of immune-mediated thrombosis" 2254: 2208: 2189: 2146: 2100: 2081: 2045: 2001: 1956: 1937: 1890: 1871: 1804: 1298:"Payouts mount for ex-Duke doc for malpractice – Triangle Business Journal" 1222: 1066: 371:"Gene-expression Patterns Predict Phenotypes of Immune-mediated Thrombosis" 2862: 2911: 2519: 2476: 2459: 2430: 2410: 2393: 1796: 1477:"Anil Potti resurfaces at South Carolina cancer center "Retraction Watch" 1019: 952:"Case Summary: Potti, Anil | ORI - the Office of Research Integrity" 555: 516: 398: 176:
to conduct a study of the proper use of genomics in clinical trials. The
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described the case as "one of the biggest medical research frauds ever".
59: 2138: 2092: 1752:"Evolution of Translational Omics: Lessons Learned and the Path Forward" 1451:. Coastal Cancer Center. Archived from the original on 16 February 2012. 938:"Ninth Potti paper to date gets retracted – Duke Chronicle, Feb 7, 2012" 127:
Potti's fraudulent research was funded by the US government through the
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Potti and his team were accused of falsifying data regarding the use of
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while a cancer researcher at both Duke University's Medical Center and
2020:"Retraction: Genomic signatures to guide the use of chemotherapeutics" 450:"Age- and Sex-Specific Genomic Profiles in Non-Small Cell Lung Cancer" 1535: 1037:
Micheel, Christine M; Nass, Sharly J; Omenn, Gilbert S, eds. (2012).
709:""Anil Potti, Duke Cancer Researcher Accused of Misconduct, Resigns"" 1694:"Site plagiarizes blog posts, then files DMCA takedown on originals" 1592:"New in PNAS: Potti retraction number seven, and a Potti correction" 1213: 1188: 850: 1403: 1048: 2013: 2011: 160:
the student not to report his experiences to the funding agency,
1614:"Potti and colleagues retract 2008 JAMA paper "Retraction Watch" 2877:"Another retraction for Anil Potti, with an inscrutable notice" 1364:"Tainted doctor working in S.C. (Charleston Post and Courier)" 978:"Universities stonewall investigations of research misconduct" 674: 672: 670: 531: 316:
This study involved patients with oestrogen-receptor-negative
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Research questions and Institute of Medicine report on 'Omics'
1145:"Duke Scientist Suspended Over Rhodes Scholar Claims.%7C2010" 247:
After leaving Duke, Potti hired Online Reputation Manager, a
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from March 2011 until 21 February 2012, when he was let go.
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had been retracted because of failure to reproduce results.
586:"Federal Register :: Findings of Research Misconduct" 327:"Genomic Signatures to Guide the Use of Chemotherapeutics" 1088: 1086: 1084: 1082: 1080: 1078: 1076: 1566:"Second lawsuit filed against Duke for Potti's research" 745:"Duke Scientist Suspended Over Rhodes Scholarship Claim" 2625:
10.1371/annotation/8f94e479-4161-43a0-a28c-4c0460bb89a4
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10.1371/annotation/8f94e479-4161-43a0-a28c-4c0460bb89a4
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In January 2011 Potti applied for a medical license in
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associate professor and cancer researcher, focusing on
1320:"Disgraced Duke researcher settles malpractice claims" 1095:"Panel Calls for Closer Oversight of Biomarker Tests" 727:"Panel Calls for Closer Oversight of Biomarker Tests" 506: 504: 502: 139:, in the form of six multi-year grants, and by the 108:statisticians, Keith Baggerly and Kevin Coombes at 2998:People involved in scientific misconduct incidents 1652:. Retractionwatch.wordpress.com. 22 February 2012. 554: 1638:. Retractionwatch.wordpress.com. 6 February 2012. 1516:. Retractionwatch.wordpress.com. 22 February 2012 912:"Rhodes scholars – Research Grants and Contracts" 789:"How Bright Promise in Cancer Testing Fell Apart" 251:company, to improve search results for his name. 1461:: CS1 maint: bot: original URL status unknown ( 1344:. Retractionwatch.wordpress.com. 5 December 2011 1281:: CS1 maint: bot: original URL status unknown ( 1269:"NBC-17 Investigates FDA findings in Duke audit" 849:. cancerletter.com. 16 July 2012. Archived from 16:Cancer scientist accused of misconduct and fraud 1594:. Retractionwatch.wordpress.com. 5 October 2011 1616:. Retractionwatch.wordpress.com. 2 April 2008 1479:. Retractionwatch.wordpress.com. 16 June 2011 1170:""Health care companies cut ties with Potti"" 54:in 1999. In 2006 Potti completed training in 52:University of North Dakota School of Medicine 8: 2498:: CS1 maint: multiple names: authors list ( 1500:"Cancer researcher Potti loses his S.C. job" 1404:"Board of Registration for the Healing Arts" 870: 868: 455:Journal of the American Medicine Association 2665:"Ninth Potti paper to date gets retracted" 738: 736: 545:"Misconduct in science An array of errors" 374:This article was published in the journal 2703: 2633: 2623: 2550: 2540: 2475: 2409: 2367: 2293: 2244: 2035: 1927: 1861: 1851: 1212: 914:. Research.unimelb.edu.au. Archived from 627:"The Anil Potti retraction record so far" 133:National Heart, Lung, and Blood Institute 2993:Medical controversies in the Netherlands 580: 578: 576: 574: 346:Journal of American Medicine Association 1664:"Potti hires online reputation manager" 1437:. Postandcourier.com. 22 February 2012. 1366:. Postandcourier.com. 15 February 2012. 1255:"Home – the Cancer Letter Publications" 483: 472:List of scientific misconduct incidents 240:authored by Potti and others have been 2491: 1546:from the original on 26 September 2011 1454: 1274: 770:""Suspended cancer trials terminated"" 1429: 1427: 1108:Check Hayden, Erika (23 March 2012). 900:. Dukechronicle.com. 11 January 2012. 813:Kilday, Patricia (18 February 2012). 7: 2667:. Dukechronicle.com. 7 February 2012 682:. Pps.ncmedboard.org. Archived from 655:. The Center of Scientific Integrity 629:. Retraction Watch. 14 February 2012 2753:Phenotype in Lung Adenocarcinoma". 1498:Debruyn, Jason (22 February 2012). 992:"Reference at www.newsobserver.com" 553:. 10 September 2011. Archived from 491:Debruyn, Jason (10 February 2012). 2879:. Retraction Watch. 5 October 2012 1758:from the original on 22 July 2014. 384:This article was published in the 362:This article was published in the 14: 1093:Kaiser, Jocelyn (23 March 2012). 835:. cancerletter.com. 16 July 2012. 2973:Ethics of science and technology 2649: 2591: 1568:. The Herald Sun. Archived from 1536:"Duke sued over clinical trials" 1296:Debruyn, Jason (13 March 2011). 878:. Duke Chronicle. 29 August 2010 876:"Resume reveals inconsistencies" 743:Singer, Natasha (20 July 2010). 453:This paper was published in the 412:This paper was published in the 2464:New England Journal of Medicine 2398:New England Journal of Medicine 1670:. 14 April 2011. Archived from 607:. Cancer Center of North Dakota 590:Findings of Research Misconduct 387:New England Journal of Medicine 172:The Potti scandal prompted the 162:Howard Hughes Medical Institute 141:Howard Hughes Medical Institute 2239:(35): 5229. 10 December 2010. 1237:""Cancer research questioned"" 1189:"Cancer trial errors revealed" 1187:Samuel Reich, Eugenie (2011). 680:"North Carolina Medical Board" 396:This article was published in 340:This article was published in 330:This article was published in 312:This article was published in 298:This article was published by 198:Duke University Medical Center 116:that Potti had claimed on his 1: 2828:10.1158/1078-0432.CCR-12-0337 2786:10.1158/1078-0432.CCR-12-0337 2767:10.1158/1078-0432.CCR-09-1939 1994:10.1016/S1470-2045(11)70011-0 1949:10.1016/S1470-2045(11)70011-0 1929:10.1016/S1470-2045(07)70345-5 605:Cancer Center of North Dakota 129:National Institutes of Health 2692:Journal of Clinical Oncology 2542:10.1371/journal.pone.0001908 2360:10.1182/blood-2011-08-375030 2315:10.1182/blood-2011-08-375030 2233:Journal of Clinical Oncology 2170:Journal of Clinical Oncology 1721:. Techdirt. 21 November 2013 1406:. Pr.mo.gov. 28 August 2011. 787:Kolata, Gina (7 July 2011). 423:This paper was published in 414:Journal of Clinical Oncology 365:Journal of Clinical Oncology 202:Food and Drug Administration 83:Office of Research Integrity 36:Office of Research Integrity 2988:Hoaxes in the United States 649:"Retraction Watch Database" 324:article that was retracted. 3014: 2286:10.1182/blood-2005-07-2669 1322:. WRAL.com. 2 January 2012 1143:Singer, N (20 July 2010). 46:Anil Potti graduated from 34:. On 9 November 2015, the 22:is a physician and former 2857:(4): 1079. October 2012. 1122:10.1038/nature.2012.10298 434:Published in the journal 196:Three clinical trials at 137:National Cancer Institute 110:MD Anderson Cancer Center 48:Christian Medical College 2816:Clinical Cancer Research 2755:Clinical Cancer Research 2725:10.1200/JCO.2012.42.0331 2705:10.1200/JCO.2006.06.3743 2246:10.1200/JCO.2010.33.7311 2201:10.1200/JCO.2010.33.7311 2182:10.1200/JCO.2007.11.0593 2074:10.1001/jama.299.13.1574 425:Clinical Cancer Research 85:(ORI), Potti engaged in 2968:Duke University faculty 1883:10.1073/pnas.1115170108 1853:10.1073/pnas.0806674105 1449:"Coastal Cancer Center" 190:American Cancer Society 1097:. News.sciencemag.org. 2863:10.1378/chest.12-1284 2780:(Retracted, see 2719:(Retracted, see 2566:(Retracted, see 2425:(Retracted, see 2309:(Retracted, see 2195:(Retracted, see 2087:(Retracted, see 1943:(Retracted, see 1877:(Retracted, see 1378:"NCMB Action Revised" 512:""Deception at Duke"" 445:Paper under suspicion 260:DMCA takedown notices 249:reputation management 178:Institute of Medicine 174:Institute of Medicine 87:scientific misconduct 77:Scientific misconduct 2912:10.1001/jama.2010.80 2477:10.1056/NEJMc1101915 2431:10.1056/NEJMc1101915 2411:10.1056/NEJMoa060467 1797:10.1001/jama.2010.80 1542:. 8 September 2011. 1420:. Dukechronicle.com. 1026:. 10 September 2011. 1020:"An array of errors" 940:. Dukechronicle.com. 524:on 13 February 2012. 273: 2983:Health fraud people 2533:2008PLoSO...3.1908S 2139:10.1001/jama.2012.2 2093:10.1001/jama.2012.2 1982:The Lancet Oncology 1844:2008PNAS..10519432G 1674:on 28 February 2013 1205:2011Natur.469..139S 155:University response 102:scientific journals 2963:Cancer researchers 2037:10.1038/nm0111-135 1149:The New York Times 1008:. 12 January 2015. 918:on 13 October 2011 793:The New York Times 749:The New York Times 588:. 9 November 2015. 534:, 12 February 2012 495:. Bizjournals.com. 254:In February 2013, 91:School of Medicine 2978:Hoaxes in science 2958:Academic scandals 2761:(24): 7553–7561. 1772:. 20 August 2012. 1300:. Bizjournals.com 1199:(7329): 139–140. 1058:978-0-309-22418-5 853:on 27 August 2016 819:Houston Chronicle 352:. The article in 238:scientific papers 114:The Cancer Letter 81:According to the 3005: 2932: 2931: 2895: 2889: 2888: 2886: 2884: 2873: 2867: 2866: 2846: 2840: 2839: 2810: 2804: 2803: 2799:Retraction Watch 2778: 2749: 2743: 2742: 2738:Retraction Watch 2717: 2707: 2683: 2677: 2676: 2674: 2672: 2661: 2655: 2654: 2653: 2647: 2637: 2627: 2603: 2597: 2596: 2595: 2589: 2585:Retraction Watch 2564: 2554: 2544: 2510: 2504: 2503: 2497: 2489: 2479: 2455: 2449: 2448: 2444:Retraction Watch 2423: 2413: 2388: 2382: 2381: 2371: 2339: 2333: 2332: 2328:Retraction Watch 2307: 2297: 2265: 2259: 2258: 2248: 2225: 2219: 2218: 2214:Retraction Watch 2193: 2164: 2158: 2157: 2155: 2153: 2117: 2111: 2110: 2106:Retraction Watch 2085: 2056: 2050: 2049: 2039: 2015: 2006: 2005: 1973: 1967: 1966: 1962:Retraction Watch 1941: 1931: 1907: 1901: 1900: 1896:Retraction Watch 1875: 1865: 1855: 1838:(49): 19432–37. 1823: 1817: 1816: 1780: 1774: 1773: 1766: 1760: 1759: 1748: 1731: 1730: 1728: 1726: 1715: 1709: 1708: 1706: 1704: 1690: 1684: 1683: 1681: 1679: 1660: 1654: 1653: 1646: 1640: 1639: 1632: 1626: 1625: 1623: 1621: 1610: 1604: 1603: 1601: 1599: 1588: 1582: 1581: 1579: 1577: 1562: 1556: 1555: 1553: 1551: 1532: 1526: 1525: 1523: 1521: 1510: 1504: 1503: 1495: 1489: 1488: 1486: 1484: 1473: 1467: 1466: 1460: 1452: 1445: 1439: 1438: 1431: 1422: 1421: 1414: 1408: 1407: 1400: 1394: 1393: 1391: 1389: 1384:on 15 April 2013 1380:. Archived from 1374: 1368: 1367: 1360: 1354: 1353: 1351: 1349: 1338: 1332: 1331: 1329: 1327: 1316: 1310: 1309: 1307: 1305: 1293: 1287: 1286: 1280: 1272: 1265: 1259: 1258: 1251: 1245: 1240: 1233: 1227: 1226: 1216: 1184: 1178: 1173: 1166: 1160: 1159: 1157: 1155: 1140: 1134: 1133: 1105: 1099: 1098: 1090: 1071: 1070: 1034: 1028: 1027: 1016: 1010: 1009: 1002: 996: 995: 988: 982: 981: 974: 968: 967: 965: 963: 954:. Archived from 948: 942: 941: 934: 928: 927: 925: 923: 908: 902: 901: 894: 888: 887: 885: 883: 872: 863: 862: 860: 858: 843: 837: 836: 829: 823: 822: 810: 804: 803: 801: 799: 784: 778: 773: 766: 760: 759: 757: 755: 740: 731: 730: 729:. 23 March 2012. 723: 717: 712: 705: 696: 695: 693: 691: 686:on 15 April 2013 676: 665: 664: 662: 660: 653:Retraction Watch 645: 639: 638: 636: 634: 623: 617: 616: 614: 612: 597: 591: 589: 582: 569: 568: 566: 564: 559:on 27 April 2020 558: 541: 535: 525: 520:. Archived from 508: 497: 496: 488: 314:Lancet Oncology. 287:Retracted papers 264:Retraction Watch 118:curriculum vitae 3013: 3012: 3008: 3007: 3006: 3004: 3003: 3002: 2938: 2937: 2936: 2935: 2897: 2896: 2892: 2882: 2880: 2875: 2874: 2870: 2848: 2847: 2843: 2812: 2811: 2807: 2779: 2751: 2750: 2746: 2718: 2685: 2684: 2680: 2670: 2668: 2663: 2662: 2658: 2648: 2605: 2604: 2600: 2590: 2565: 2512: 2511: 2507: 2490: 2457: 2456: 2452: 2424: 2390: 2389: 2385: 2341: 2340: 2336: 2308: 2267: 2266: 2262: 2227: 2226: 2222: 2194: 2166: 2165: 2161: 2151: 2149: 2119: 2118: 2114: 2086: 2068:(13): 1574–87. 2058: 2057: 2053: 2024:Nature Medicine 2017: 2016: 2009: 1975: 1974: 1970: 1942: 1922:(12): 1071–78. 1916:Lancet Oncology 1909: 1908: 1904: 1876: 1825: 1824: 1820: 1782: 1781: 1777: 1768: 1767: 1763: 1750: 1749: 1734: 1724: 1722: 1717: 1716: 1712: 1702: 1700: 1692: 1691: 1687: 1677: 1675: 1662: 1661: 1657: 1648: 1647: 1643: 1634: 1633: 1629: 1619: 1617: 1612: 1611: 1607: 1597: 1595: 1590: 1589: 1585: 1575: 1573: 1572:on 12 June 2012 1564: 1563: 1559: 1549: 1547: 1534: 1533: 1529: 1519: 1517: 1512: 1511: 1507: 1497: 1496: 1492: 1482: 1480: 1475: 1474: 1470: 1453: 1447: 1446: 1442: 1433: 1432: 1425: 1416: 1415: 1411: 1402: 1401: 1397: 1387: 1385: 1376: 1375: 1371: 1362: 1361: 1357: 1347: 1345: 1340: 1339: 1335: 1325: 1323: 1318: 1317: 1313: 1303: 1301: 1295: 1294: 1290: 1273: 1267: 1266: 1262: 1253: 1252: 1248: 1235: 1234: 1230: 1214:10.1038/469139a 1186: 1185: 1181: 1168: 1167: 1163: 1153: 1151: 1142: 1141: 1137: 1107: 1106: 1102: 1092: 1091: 1074: 1059: 1036: 1035: 1031: 1018: 1017: 1013: 1004: 1003: 999: 990: 989: 985: 980:. 5 April 2016. 976: 975: 971: 961: 959: 950: 949: 945: 936: 935: 931: 921: 919: 910: 909: 905: 896: 895: 891: 881: 879: 874: 873: 866: 856: 854: 845: 844: 840: 831: 830: 826: 812: 811: 807: 797: 795: 786: 785: 781: 768: 767: 763: 753: 751: 742: 741: 734: 725: 724: 720: 707: 706: 699: 689: 687: 678: 677: 668: 658: 656: 647: 646: 642: 632: 630: 625: 624: 620: 610: 608: 599: 598: 594: 584: 583: 572: 562: 560: 543: 542: 538: 510: 509: 500: 490: 489: 485: 480: 468: 447: 404:Nature Medicine 354:Nature Medicine 350:Nature Medicine 332:Nature Medicine 322:Nature Medicine 289: 276: 226:the research." 209:medical license 186: 170: 157: 122:Rhodes Scholars 79: 64:Duke University 44: 32:Duke University 24:Duke University 17: 12: 11: 5: 3011: 3009: 3001: 3000: 2995: 2990: 2985: 2980: 2975: 2970: 2965: 2960: 2955: 2950: 2940: 2939: 2934: 2933: 2890: 2868: 2841: 2805: 2744: 2678: 2656: 2598: 2505: 2450: 2383: 2334: 2280:(4): 1391–96. 2260: 2220: 2176:(28): 4350–7. 2159: 2112: 2051: 2007: 1968: 1902: 1818: 1775: 1761: 1732: 1710: 1685: 1655: 1641: 1627: 1605: 1583: 1557: 1527: 1505: 1490: 1468: 1440: 1423: 1409: 1395: 1369: 1355: 1333: 1311: 1288: 1260: 1246: 1243:Duke Chronicle 1228: 1179: 1176:Duke Chronicle 1161: 1135: 1116:. Nature.com. 1100: 1072: 1057: 1049:10.17226/13297 1029: 1011: 997: 983: 969: 958:on 5 July 2017 943: 929: 903: 889: 864: 838: 824: 805: 779: 776:Duke Chronicle 761: 732: 718: 715:Duke Chronicle 697: 666: 640: 618: 592: 570: 536: 498: 482: 481: 479: 476: 475: 474: 467: 464: 463: 462: 451: 446: 443: 442: 441: 432: 429: 421: 418: 410: 407: 394: 391: 382: 379: 372: 369: 360: 357: 338: 335: 328: 325: 310: 307: 296: 288: 285: 275: 272: 216:South Carolina 185: 182: 169: 166: 156: 153: 78: 75: 43: 40: 15: 13: 10: 9: 6: 4: 3: 2: 3010: 2999: 2996: 2994: 2991: 2989: 2986: 2984: 2981: 2979: 2976: 2974: 2971: 2969: 2966: 2964: 2961: 2959: 2956: 2954: 2953:Living people 2951: 2949: 2946: 2945: 2943: 2929: 2925: 2921: 2917: 2913: 2909: 2906:(6): 535–43. 2905: 2901: 2894: 2891: 2878: 2872: 2869: 2864: 2860: 2856: 2852: 2845: 2842: 2837: 2833: 2829: 2825: 2821: 2817: 2809: 2806: 2801: 2800: 2795: 2791: 2787: 2783: 2776: 2772: 2768: 2764: 2760: 2756: 2748: 2745: 2740: 2739: 2734: 2730: 2726: 2722: 2715: 2711: 2706: 2701: 2698:(5): 517–25. 2697: 2693: 2689: 2682: 2679: 2666: 2660: 2657: 2652: 2645: 2641: 2636: 2631: 2626: 2621: 2617: 2613: 2609: 2602: 2599: 2594: 2587: 2586: 2581: 2577: 2573: 2569: 2562: 2558: 2553: 2548: 2543: 2538: 2534: 2530: 2526: 2522: 2521: 2516: 2509: 2506: 2501: 2495: 2487: 2483: 2478: 2473: 2469: 2465: 2461: 2454: 2451: 2446: 2445: 2440: 2436: 2432: 2428: 2421: 2417: 2412: 2407: 2404:(6): 570–80. 2403: 2399: 2395: 2387: 2384: 2379: 2375: 2370: 2365: 2361: 2357: 2353: 2349: 2345: 2338: 2335: 2330: 2329: 2324: 2320: 2316: 2312: 2305: 2301: 2296: 2291: 2287: 2283: 2279: 2275: 2271: 2264: 2261: 2256: 2252: 2247: 2242: 2238: 2234: 2230: 2224: 2221: 2216: 2215: 2210: 2206: 2202: 2198: 2191: 2187: 2183: 2179: 2175: 2171: 2163: 2160: 2148: 2144: 2140: 2136: 2132: 2128: 2124: 2116: 2113: 2108: 2107: 2102: 2098: 2094: 2090: 2083: 2079: 2075: 2071: 2067: 2063: 2055: 2052: 2047: 2043: 2038: 2033: 2029: 2025: 2021: 2014: 2012: 2008: 2003: 1999: 1995: 1991: 1987: 1983: 1979: 1972: 1969: 1964: 1963: 1958: 1954: 1950: 1946: 1939: 1935: 1930: 1925: 1921: 1917: 1913: 1906: 1903: 1898: 1897: 1892: 1888: 1884: 1880: 1873: 1869: 1864: 1859: 1854: 1849: 1845: 1841: 1837: 1833: 1829: 1822: 1819: 1814: 1810: 1806: 1802: 1798: 1794: 1791:(6): 535–43. 1790: 1786: 1779: 1776: 1771: 1765: 1762: 1757: 1753: 1747: 1745: 1743: 1741: 1739: 1737: 1733: 1720: 1714: 1711: 1699: 1695: 1689: 1686: 1673: 1669: 1668:The Chronicle 1665: 1659: 1656: 1651: 1645: 1642: 1637: 1631: 1628: 1615: 1609: 1606: 1593: 1587: 1584: 1571: 1567: 1561: 1558: 1545: 1541: 1537: 1531: 1528: 1515: 1509: 1506: 1501: 1494: 1491: 1478: 1472: 1469: 1464: 1458: 1450: 1444: 1441: 1436: 1430: 1428: 1424: 1419: 1413: 1410: 1405: 1399: 1396: 1383: 1379: 1373: 1370: 1365: 1359: 1356: 1343: 1337: 1334: 1321: 1315: 1312: 1299: 1292: 1289: 1284: 1278: 1270: 1264: 1261: 1256: 1250: 1247: 1244: 1238: 1232: 1229: 1224: 1220: 1215: 1210: 1206: 1202: 1198: 1194: 1190: 1183: 1180: 1177: 1171: 1165: 1162: 1150: 1146: 1139: 1136: 1131: 1127: 1123: 1119: 1115: 1111: 1104: 1101: 1096: 1089: 1087: 1085: 1083: 1081: 1079: 1077: 1073: 1068: 1064: 1060: 1054: 1050: 1046: 1042: 1041: 1033: 1030: 1025: 1024:The Economist 1021: 1015: 1012: 1007: 1001: 998: 993: 987: 984: 979: 973: 970: 957: 953: 947: 944: 939: 933: 930: 917: 913: 907: 904: 899: 893: 890: 877: 871: 869: 865: 852: 848: 842: 839: 834: 828: 825: 820: 816: 809: 806: 794: 790: 783: 780: 777: 771: 765: 762: 750: 746: 739: 737: 733: 728: 722: 719: 716: 710: 704: 702: 698: 685: 681: 675: 673: 671: 667: 654: 650: 644: 641: 628: 622: 619: 606: 602: 596: 593: 587: 581: 579: 577: 575: 571: 557: 552: 551: 550:The Economist 546: 540: 537: 533: 529: 523: 519: 518: 513: 507: 505: 503: 499: 494: 487: 484: 477: 473: 470: 469: 465: 460: 456: 452: 449: 448: 444: 439: 438: 433: 430: 426: 422: 419: 415: 411: 408: 405: 401: 400: 395: 392: 389: 388: 383: 380: 377: 373: 370: 367: 366: 361: 358: 355: 351: 347: 343: 339: 336: 333: 329: 326: 323: 319: 318:breast cancer 315: 311: 308: 305: 301: 297: 294: 293: 292: 286: 284: 280: 271: 269: 265: 261: 257: 252: 250: 245: 243: 239: 235: 231: 230:Robert Califf 227: 223: 221: 217: 212: 210: 205: 203: 199: 194: 191: 183: 181: 179: 175: 168:Investigation 167: 165: 163: 154: 152: 150: 149: 144: 142: 138: 134: 130: 125: 123: 119: 115: 111: 107: 106:bioinformatic 103: 99: 94: 92: 88: 84: 76: 74: 71: 67: 65: 61: 57: 53: 49: 41: 39: 37: 33: 29: 25: 21: 2903: 2899: 2893: 2881:. 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Index

Duke University
oncogenomics
Duke University
Office of Research Integrity
Christian Medical College
University of North Dakota School of Medicine
hematology
oncology
Duke University
Office of Research Integrity
scientific misconduct
School of Medicine
microarray
scientific journals
bioinformatic
MD Anderson Cancer Center
The Cancer Letter
curriculum vitae
Rhodes Scholars
National Institutes of Health
National Heart, Lung, and Blood Institute
National Cancer Institute
Howard Hughes Medical Institute
60 Minutes
Howard Hughes Medical Institute
Institute of Medicine
Institute of Medicine
American Cancer Society
Duke University Medical Center
Food and Drug Administration

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