183:(UW-M) in 1999 with a joint appointment in the Departments of Pediatrics and Pharmacology, and as an associate director of the Medical Scientist Training Program (MSTP). In this role, Huttenlocher's research has defined cellular and molecular mechanisms that regulate cell migration and identified basic adhesive mechanisms that regulate cell migration and leukocyte chemotaxis. By 2005, her research team had identified a novel pathway that turned out to be critical for cell migration and chemotaxis, involving intracellular proteolysis by the calcium-dependent protease calpain. Her laboratory was also the first to document reverse migration of neutrophils away from sites of injury or inflammation. In 2011 her group reported the first redox sensor that mediates leukocyte attraction to wounds. In 2005 she was elected a member of the
187:. Huttenlocher was promoted to Professor with tenure in 2008 and was the recipient of the Graduate School’s H.I. Romnes Fellowship award. She also received the Burroughs-Wellcome Fund’s Clinical Scientist Award in Translational Research for her project "Diagnosis and Treatment of Autoinflammatory Disease." Huttenlocher was the recipient of a 2011 WARF Kellett Mid-Career Award. Until 2023 she conducted this work while maintaining an active clinical practice as a pediatric rheumatologist.
207:
Carbone Cancer Center recognized with the
Society for the Immunotherapy of Cancer’s Team Science Award for "long-standing contribution to the field of cancer immunotherapy over the past 35 years." Huttenlocher's recent research projects include "Cell migration and wound repair" and "Imaging immunometabolism in live animals during host defense."
199:"for her pioneering studies of cell migration and alterations of cell migration in human diseases." In 2017, Huttenlocher was awarded a UW2020 grant to support her project "Engineering leukocytes generated from human iPS cells to treat human disease." At the same time, she was also elected a Fellow of the
210:
In 2023, Huttenlocher published the book "From Loss to Memory: Behind the
Discovery of Synaptic Pruning". It describes the discovery of synaptic pruning and its current relevance to early learning, autism, schizophrenia and Alzheimer's disease. The book centers on the intriguing life story of the
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In May 2020, Huttenlocher was named the Anna Ruth
Brummett Professor of Pediatrics and Medical Microbiology and Immunology Chair in honor of her "major contributions to the advancement of knowledge." The following year, she was part of a large team of researchers from the University of Wisconsin
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Mathias, J. R., Perrin, B. J., Liu, T. X., Kanki, J., Look, A. T., & Huttenlocher, A. (2006). Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish. Journal of
Leukocyte Biology, 80(6), 1281–1288.
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Franco, S. J., Rodgers, M. A., Perrin, B. J., Han, J., Bennin, D. A., Critchley, D. R., & Huttenlocher, A. (2004). Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nature cell biology, 6(10), 977–983.
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In 2012, Huttenlocher was appointed as
Director of the UW-Madison MD-PhD training program (MSTP), succeeding Deane Mosher. She was active in that role for over ten years. During that time she was also elected into the
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Lokuta, M. A., Nuzzi, P. A., & Huttenlocher, A. (2003). Calpain regulates neutrophil chemotaxis. Proceedings of the
National Academy of Sciences of the United States of America, 100(7), 4006–4011.
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Yoo, S. K., Starnes, T. W., Deng, Q., & Huttenlocher, A. (2011). Lyn is a redox sensor that mediates leukocyte wound attraction in vivo. Nature, 480(7375), 109–112.
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de
Oliveira, S., Rosowski, E. & Huttenlocher, A. Neutrophil migration in infection and wound repair: going forward in reverse. Nat Rev Immunol 16, 378–391 (2016).
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discoverer of synaptic pruning, her father Peter
Huttenlocher, and also discusses the physician-scientist career path.
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435:"ANNA HUTTENLOCHER, MD, RECEIVES THE BURROUGHS-WELLCOME FUND'S CLINICAL SCIENTIST AWARD"
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593:"PEDIATRIC 'DREAM TEAM' MEMBERS AND OTHERS RECOGNIZED WITH SITC'S TEAM SCIENCE AWARD"
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615:"ANNA HUTTENLOCHER RECEIVES $ 3.3M NIH AWARD TO FURTHER CELL MIGRATION RESEARCH"
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549:"DR. ANNA HUTTENLOCHER ELECTED AS AN AMERICAN SOCIETY FOR CELL BIOLOGY FELLOW"
413:"DR. ANNA HUTTENLOCHER AWARDED GRADUATE SCHOOL'S H.I. ROMNES FELLOWSHIP AWARD"
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479:"ANNA HUTTENLOCHER, MD, ELECTED TO THE ASSOCIATION OF AMERICAN PHYSICIANS"
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501:"ANNA HUTTENLOCHER, MD, ELECTED TO NATIONAL ACADEMY OF MEDICINE"
457:"DR. ANNA HUTTENLOCHER, MD, EARNS WARF KELLETT MID-CAREER AWARD"
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From Loss to Memory: Behind the
Discovery of Synaptic Pruning
195:. In 2015 Dr. Huttenlocher was inducted as a Member of the
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Huttenlocher was born to two academic parents; her father,
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Members of the
American Society for Clinical Investigation
637:"DR. ANNA HUTTENLOCHER AWARDED TWO-YEAR NIH-NIAID GRANT"
230:"Peter Huttenlocher, pediatric neurologist, 1931-2013"
571:"DR. HUTTENLOCHER RECEIVES WARF NAMED PROFESSORSHIP"
595:. University of Wisconsin–Madison. January 10, 2021
481:. University of Wisconsin–Madison. February 1, 2012
163:. Following Harvard, she completed her training at
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551:. University of Wisconsin–Madison. October 1, 2017
459:. University of Wisconsin–Madison. January 1, 2011
639:. University of Wisconsin–Madison. March 24, 2021
743:Fellows of the American Society for Cell Biology
617:. University of Wisconsin–Madison. June 29, 2021
573:. University of Wisconsin–Madison. May 13, 2020
529:. University of Wisconsin-Madison. June 1, 2017
527:"ANNA HUTTENLOCHER, MD, AWARDED A UW2020 GRANT"
437:. University of Wisconsin–Madison. May 1, 2008
415:. University of Wisconsin–Madison. May 1, 2008
393:. University of Wisconsin–Madison. May 1, 2008
143:, was a pediatric neurologist and her mother,
664:. Cambridge, UK: Cambridge University Press.
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728:Members of the National Academy of Medicine
370:American Society for Clinical Investigation
185:American Society for Clinical Investigation
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391:"FACULTY PROMOTIONS AS OF MARCH 3, 2008"
147:, was a psychologist. She completed her
304:https://doi.org/10.1073/pnas.0636533100
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179:Huttenlocher joined the faculty at the
169:University of California, San Francisco
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723:American women molecular biologists
354:https://doi.org/10.1038/nature10632
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738:Harvard Medical School alumni
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252:"Professor Anna Huttenlocher"
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232:. University of Chicago
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161:Harvard Medical School
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