312:
289:
186:
211:
563:
3230:
3245:
318:
217:
1749:. Following cell activation (for example, by neutrophil adhesion to endothelial-cell monolayers), annexin A1 is promptly mobilized to the cell surface and secreted. Annexin A1 promotes neutrophil detachment and apoptosis, and phagocytosis of apoptotic neutrophils by macrophages. On the other hand, it reduces the tendency of neutrophils to penetrate the
31:
1891:
induced by heat in breast cancer cells, adding to the evidence that it has tumor suppressive and protective activities. When ANXA1 is silenced or lost in cancer, cells are more prone to DNA damage, indicating its unidentified diverse role in genome maintenance or integrity. Annexin A1 has also been
1768:
Annexin A1 has important opposing properties during innate and adaptive immune responses: it inhibits innate immune cells and promotes T-cell activation. The activation of T cells results in the release of annexin A1 and the expression of its receptor. This pathway seems to fine-tune the strength of
1879:
reverses the estrogen-dependent proliferation as well as growth arrest. ANXA1 is lost in clinical breast cancer, indicating that the anti-proliferative protective function of ANXA1 against high levels of estrogen may be lost in breast cancer. This data suggests that ANXA1 may act as a
57:
1769:
TCR signalling. Higher expression of annexin A1 during pathological conditions could increase the strength of TCR signalling through the mitogen-activated protein kinase signalling pathway, thereby causing a state of hyperactivation of T cells.
3100:
Manda R, Kohno T, Matsuno Y, Takenoshita S, Kuwano H, Yokota J (October 1999). "Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display".
2671:
Varticovski L, Chahwala SB, Whitman M, Cantley L, Schindler D, Chow EP, et al. (May 1988). "Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C".
1875:. Treatment of MCF-7 cells with physiological levels of estrogen (1 nM) induced proliferation while high pregnancy levels of estrogen (100 nM) induced a growth arrest of MCF-7 cells. Silencing of ANXA1 with specific
1855:
Altered annexin A1 expression levels through modulation of the immune system effects the initiation and spread of breast cancer, but the association is complex and conclusions of published studies often conflict.
1991:
Wallner BP, Mattaliano RJ, Hession C, Cate RL, Tizard R, Sinclair LK, et al. (1986). "Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity".
3703:
2298:
Falini B, Tiacci E, Liso A, Basso K, Sabattini E, Pacini R, et al. (June 2004). "Simple diagnostic assay for hairy cell leukaemia by immunocytochemical detection of annexin A1 (ANXA1)".
2950:
Morgan RO, FernΓ‘ndez MP (December 1995). "A BC200-derived element and Z-DNA as structural markers in annexin I genes: relevance to Alu evolution and annexin tetrad formation".
1843:. ANXA1 protein expression is specific to hairy cell leukemia. Detection of ANXA1 (by immunocytochemical means) reportedly provides a simple, highly sensitive, and specific
2779:
Huebner K, Cannizzaro LA, Frey AZ, Hecht BK, Hecht F, Croce CM, Wallner BP (May 1988). "Chromosomal localization of the human genes for lipocortin I and lipocortin II".
325:
224:
2341:
Tu Y, Johnstone CN, Stewart AG (May 2017). "Annexin A1 influences in breast cancer: Controversies on contributions to tumour, host and immunoediting processes".
3688:
3285:
4386:
3229:
1296:
1277:
147:
1675:
The main mechanism of glucocorticoids' anti-inflammatory effects is to increase the synthesis and function of annexin A1. Annexin A1 both suppresses
2153:"Glucocorticoids inhibit prostaglandin synthesis not only at the level of phospholipase A2 but also at the level of cyclo-oxygenase/PGE isomerase"
2642:
Kovacic RT, Tizard R, Cate RL, Frey AZ, Wallner BP (September 1991). "Correlation of gene and protein structure of rat and human lipocortin I".
3783:
3244:
2609:"Calcium-induced intracellular cross-linking of lipocortin I by tissue transglutaminase in A431 cells. Augmentation by membrane phospholipids"
4411:
3209:
1973:
4406:
3503:
1955:
1896:
loss activates annexin A1 expression, which is required for drug resistance (mTOR inhibitor or trastuzumab) through its activation of AKT.
1816:
1727:
2417:
Nair S, Hande MP, Lim LH (August 2010). "Annexin-1 protects MCF7 breast cancer cells against heat-induced growth arrest and DNA damage".
311:
54:
3148:
2251:"Annexin 1 induced by anti-inflammatory drugs binds to NF-kappaB and inhibits its activation: anticancer effects in vitro and in vivo"
1507:
1500:
288:
1710:, etc.). In other words, glucocorticoids not only suppress immune response, but also inhibit the two main products of inflammation,
1765:
and the generation of proinflammatory mediators, which ensures that a sufficient level of activation is reached but not exceeded.
2046:
3721:
3711:
3278:
1942:
1921:
1593:-binding proteins that have a molecular weight of approximately 35,000 to 40,000 Dalton and are preferentially located on the
2800:
Biemann K, Scoble HA (August 1987). "Characterization by tandem mass spectrometry of structural modifications in proteins".
1938:
1761:
analyses show that exogenous and endogenous annexin A1 counter-regulate the activities of innate immune cells, particularly
3154:
210:
185:
3471:
3442:
2108:
Perretti M, D'Acquisto F (January 2009). "Annexin A1 and glucocorticoids as effectors of the resolution of inflammation".
1917:
2202:"Glucocorticoid-and non-glucocorticoid induction of lipocortins (annexins) 1 and 2 in rat peritoneal leucocytes in vivo"
127:
4053:
3862:
1664:. Because they suppress inflammatory pathways, long-term use of glucocorticoid drugs can lead to side-effects such as
324:
223:
4299:
3271:
317:
216:
3202:
2060:
Rhen T, Cidlowski JA (October 2005). "Antiinflammatory action of glucocorticoids--new mechanisms for old drugs".
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3538:
3432:
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1341:
135:
3847:
1872:
1641:
1322:
3263:
3496:
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3486:
3481:
3476:
1648:
animal cell. They are used in medicine to treat diseases caused by an overactive immune system, including
3683:
2578:
Dawson SJ, White LA (May 1992). "Treatment of
Haemophilus aphrophilus endocarditis with ciprofloxacin".
1881:
1876:
1669:
2839:"Structural characterization of a biologically active human lipocortin 1 expressed in Escherichia coli"
1597:
face of the plasma membrane. Annexin A1 protein has an apparent relative molecular mass of 40 kDa with
4228:
3195:
2959:
2809:
2001:
199:
4194:
4011:
3666:
3160:
2454:"Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance"
2378:"Annexin-1 regulates growth arrest induced by high levels of estrogen in MCF-7 breast cancer cells"
1840:
1657:
114:
2498:
Crompton MR, Moss SE, Crumpton MJ (October 1988). "Diversity in the lipocortin/calpactin family".
4274:
3716:
3646:
3636:
3508:
3464:
3319:
3302:
2983:
2566:
2523:
2452:
Berns K, Sonnenblick A, Gennissen A, BrohΓ©e S, Hijmans EM, Evers B, et al. (November 2016).
2323:
2133:
2085:
2025:
159:
3621:
2746:"Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein"
1483:
1462:
1436:
1415:
3032:"Lipocortin 1 co-associates with cytokeratins 8 and 18 in A549 cells via the N-terminal domain"
4289:
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2017:
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107:
47:
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2009:
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signal transduction pathway, which is exploited by cancerous cells to proliferate and avoid
1719:
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1598:
404:
335:
279:
234:
4156:
3397:
1047:
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
562:
155:
4367:
3530:
3424:
3362:
2837:
Arcone R, Arpaia G, Ruoppolo M, Malorni A, Pucci P, Marino G, et al. (January 1993).
1637:
379:
3067:"NMR solution structure of domain 1 of human annexin I shows an autonomous folding unit"
2963:
2813:
2005:
4339:
3437:
3294:
2898:
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2838:
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2702:
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3137:
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3031:
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Croxtall JD, Wu HL, Yang HY, Smith B, Sutton C, Chang BI, et al. (January 1998).
2762:
2745:
2625:
2608:
2591:
2311:
1867:
lead to an up-regulation of annexin A1 expression partially through the activation of
1211:
1206:
1201:
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591:
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139:
3013:
2996:
2995:
Almawi WY, Saouda MS, Stevens AC, Lipman ML, Barth CM, Strom TB (December 1996).
2430:
163:
4324:
4304:
4279:
3901:
3884:
3879:
3651:
3641:
3342:
3332:
1978:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1960:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1790:
1750:
1742:
1734:
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480:
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4189:
3988:
3852:
3837:
3800:
3631:
3616:
3611:
3606:
3601:
3596:
3591:
2997:"Partial mediation of glucocorticoid antiproliferative effects by lipocortins"
1888:
1812:
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1695:
1688:
1680:
1645:
1630:
1618:
296:
193:
143:
4347:
4219:
4204:
4199:
3889:
3857:
3795:
2821:
1824:
1746:
1738:
1726:/PGE isomerase (COX-1 and COX-2), the latter effect being much like that of
1684:
1649:
1241:
540:
418:
363:
350:
262:
249:
151:
3122:
3114:
3083:
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2403:
2362:
2319:
2284:
2129:
2081:
3092:
3057:
3022:
2979:
2942:
2933:
2917:"Calcium-dependent binding of S100C to the N-terminal domain of annexin I"
2916:
2907:
2864:
2829:
2792:
2771:
2736:
2693:
2663:
2634:
2599:
2553:
2536:
2519:
2235:
2186:
2021:
1547:
1542:
4352:
4113:
4024:
3842:
3787:
3327:
2073:
1864:
1820:
1622:
1531:
1390:
1371:
1367:
2685:
2655:
1207:
positive regulation of cell migration involved in sprouting angiogenesis
4362:
4316:
4237:
4121:
4034:
3771:
3626:
3578:
3181:
3171:
2971:
1594:
1586:
1567:
1353:
1308:
2718:
84:
80:
76:
4171:
4141:
4083:
4078:
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4068:
4063:
4045:
3872:
3867:
3825:
3820:
3766:
3754:
3749:
3744:
3548:
3543:
2744:
Kaplan R, Jaye M, Burgess WH, Schlaepfer DD, Haigler HT (June 1988).
2013:
1893:
1661:
1653:
1515:
1263:
2121:
2701:
Pepinsky RB, Sinclair LK, Chow EP, O'Brine-Greco B (October 1989).
1863:
breast cancer cells to high physiological levels (up to 100 nM) of
4262:
4257:
4252:
4247:
4242:
4166:
4161:
4151:
4146:
4136:
4131:
4126:
4095:
4090:
4058:
4029:
3998:
3993:
3983:
3971:
3966:
3961:
3894:
3815:
3810:
3805:
3739:
3412:
3407:
3402:
3392:
3387:
3382:
3377:
3238:: CRYSTAL STRUCTURE OF HUMAN ANNEXIN I AT 2.5 ANGSTROMS RESOLUTION
2872:
Weng X, Luecke H, Song IS, Kang DS, Kim SH, Huber R (March 1993).
1860:
1844:
1819:
and other potent anti-inflammatory drugs, annexin A1 inhibits the
1226:
1222:
4294:
3956:
3951:
3946:
3941:
3936:
3931:
3926:
3921:
3560:
3518:
3513:
3372:
3367:
3357:
3352:
3347:
3337:
1868:
1828:
1574:
1202:
cellular response to vascular endothelial growth factor stimulus
131:
30:
3267:
3191:
3187:
2200:
Peers SH, Smillie F, Elderfield AJ, Flower RJ (January 1993).
2103:
2101:
2099:
1799:
stimulate production of lipocortin. In this way, synthesis of
571:
3036:
Biochimica et
Biophysica Acta (BBA) - Molecular Cell Research
2376:
Ang EZ, Nguyen HT, Sim HL, Putti TC, Lim LH (February 2009).
3166:
Overview of all the structural information available in the
1793:, annexin A1 may have potential anti-inflammatory activity.
1733:
In resting conditions, human and mouse immune cells such as
987:
positive regulation of G1/S transition of mitotic cell cycle
1827:. ANXA1 inhibits the activation of NF-ΞΊB by binding to the
932:
myoblast migration involved in skeletal muscle regeneration
2874:"Crystal structure of human annexin I at 2.5 A resolution"
1057:
positive regulation of prostaglandin biosynthetic process
2915:
Mailliard WS, Haigler HT, Schlaepfer DD (January 1996).
387:
3253:: NMR SOLUTION STRUCTURE OF DOMAIN 1 OF HUMAN ANNEXIN I
2607:
Ando Y, Imamura S, Owada MK, Kannagi R (January 1991).
1884:
and modulate the proliferative functions of estrogens.
1811:
Annexin A1 has been of interest for use as a potential
1718:. They inhibit prostaglandin synthesis at the level of
766:
extrinsic component of external side of plasma membrane
2151:
Goppelt-Struebe M, Wolter D, Resch K (December 1989).
1037:
positive regulation of T-helper 1 cell differentiation
952:
negative regulation of T-helper 2 cell differentiation
552:
4337:
4315:
4227:
4217:
4182:
4111:
4043:
4009:
3782:
3732:
3702:
3674:
3664:
3577:
3559:
3529:
3423:
3318:
3309:
1476:
1455:
1429:
1408:
1122:
positive regulation of neutrophil apoptotic process
2703:"A dimeric form of lipocortin-1 in human placenta"
1934:
1932:
1930:
1913:
1911:
1909:
1892:shown to be associated with treatment resistance.
1839:The gene for annexin A1 (ANXA1) is upregulated in
334:
233:
2249:Zhang Z, Huang L, Zhao W, Rigas B (March 2010).
972:negative regulation of phospholipase A2 activity
1067:positive regulation of interleukin-2 production
690:cadherin binding involved in cell-cell adhesion
16:Protein-coding gene in the species Homo sapiens
1939:GRCm38: Ensembl release 89: ENSMUSG00000024659
3279:
3203:
1730:, potentiating the anti-inflammatory effect.
8:
2537:"Annexin 1: the new face of an old molecule"
1192:G protein-coupled receptor signaling pathway
992:cellular response to glucocorticoid stimulus
1918:GRCh38: Ensembl release 89: ENSG00000135046
1777:Since phospholipase A2 is required for the
1745:contain high levels of annexin A1 in their
1147:regulation of cell population proliferation
997:positive regulation of T cell proliferation
4387:United States National Library of Medicine
4224:
3671:
3315:
3286:
3272:
3264:
3210:
3196:
3188:
1847:for the diagnosis of hairy cell leukemia.
1237:
587:
375:
274:
171:
65:
3140:at the U.S. National Library of Medicine
3082:
3047:
3012:
2932:
2897:
2854:
2761:
2726:
2624:
2552:
2469:
2393:
2274:
2225:
2176:
1212:negative regulation of catalytic activity
4385:This article incorporates text from the
2041:
2039:
1167:negative regulation of protein secretion
1157:positive regulation of apoptotic process
1052:negative regulation of apoptotic process
881:collagen-containing extracellular matrix
801:extrinsic component of endosome membrane
640:ATP-dependent DNA/DNA annealing activity
3225:
1905:
1644:(GR), which is present in almost every
927:cell surface receptor signaling pathway
1610:Effect on innate and adaptive immunity
1182:cellular response to hydrogen peroxide
1042:regulation of interleukin-1 production
675:calcium-dependent phospholipid binding
610:protein-macromolecule adaptor activity
20:
1871:, and dependent on activation of the
1062:positive regulation of vesicle fusion
625:double-stranded DNA helicase activity
339:
300:
295:
238:
197:
192:
7:
967:positive regulation of wound healing
511:endothelial cell of lymphatic vessel
3071:The Journal of Biological Chemistry
3065:Gao J, Li Y, Yan H (January 1999).
2921:The Journal of Biological Chemistry
2750:The Journal of Biological Chemistry
2613:The Journal of Biological Chemistry
2062:The New England Journal of Medicine
1197:cytokine-mediated signaling pathway
1102:response to organic cyclic compound
1072:regulation of inflammatory response
650:phospholipase A2 inhibitor activity
2856:10.1111/j.1432-1033.1993.tb19904.x
2218:10.1111/j.1476-5381.1993.tb13441.x
2169:10.1111/j.1476-5381.1989.tb12676.x
1473:
1452:
1426:
1405:
1381:
1358:
1332:
1313:
1287:
1268:
557:
475:
413:
392:
14:
1815:drug. Upon induction by modified
1683:production, and inhibits various
1092:actin cytoskeleton reorganization
1082:alpha-beta T cell differentiation
1022:negative regulation of exocytosis
982:regulation of leukocyte migration
660:protein homodimerization activity
620:calcium-dependent protein binding
3243:
3228:
2843:European Journal of Biochemistry
2535:Lim LH, Pervaiz S (April 2007).
680:phospholipase inhibitor activity
561:
323:
316:
310:
287:
222:
215:
209:
184:
29:
3722:Calcium-induced calcium release
2206:British Journal of Pharmacology
2157:British Journal of Pharmacology
2047:"Entrez Gene: ANXA1 annexin A1"
1162:regulation of hormone secretion
821:extrinsic component of membrane
3443:Ionotropic glutamate receptors
2952:Journal of Molecular Evolution
942:endocrine pancreas development
572:More reference expression data
541:More reference expression data
1:
3049:10.1016/S0167-4889(97)00120-1
2763:10.1016/S0021-9258(18)68438-8
2626:10.1016/S0021-9258(17)35288-2
2592:10.1016/S0163-4453(05)80037-4
2471:10.1158/1078-0432.CCR-15-2996
2395:10.1158/1541-7786.MCR-08-0147
2312:10.1016/S0140-6736(04)16356-3
2267:10.1158/0008-5472.CAN-09-4204
1887:Annexin A1 protects against
308:
207:
4412:Peripheral membrane proteins
4295:Dentin matrix phosphoprotein
3014:10.4049/jimmunol.157.12.5231
2512:10.1016/0092-8674(88)90002-5
2431:10.1016/j.canlet.2010.01.026
1117:keratinocyte differentiation
851:cytoplasmic vesicle membrane
615:structural molecule activity
4407:Genes on human chromosome 9
1781:of the potent mediators of
1722:as well as at the level of
1107:response to peptide hormone
836:basolateral plasma membrane
685:single-stranded RNA binding
665:single-stranded DNA binding
4428:
4300:Dentin sialophosphoprotein
3159:gene details page in the
2355:10.1016/j.phrs.2017.02.011
2110:Nature Reviews. Immunology
1585:Annexin A1 belongs to the
1132:response to corticosteroid
1112:response to glucocorticoid
1017:arachidonic acid secretion
922:prostate gland development
917:hepatocyte differentiation
876:protein-containing complex
695:DNA/DNA annealing activity
630:signaling receptor binding
3762:Sodium-calcium exchangers
3539:Sodium-calcium exchangers
3223:
2382:Molecular Cancer Research
1974:"Mouse PubMed Reference:"
1956:"Human PubMed Reference:"
1546:
1541:
1537:
1530:
1514:
1495:
1480:
1459:
1448:
1433:
1412:
1401:
1388:
1384:
1365:
1361:
1352:
1339:
1335:
1320:
1316:
1307:
1294:
1290:
1275:
1271:
1262:
1247:
1240:
1236:
1220:
902:response to interleukin-1
590:
586:
569:
560:
551:
538:
487:
478:
461:epithelium of nasopharynx
425:
416:
386:
378:
374:
357:
344:
307:
286:
277:
273:
256:
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206:
183:
174:
170:
125:
122:
112:
105:
100:
73:
68:
51:
46:
41:
37:
28:
23:
3848:Neuronal calcium sensors
3569:Calcium-sensing receptor
3142:Medical Subject Headings
2580:The Journal of Infection
2458:Clinical Cancer Research
2343:Pharmacological Research
1508:Chr 19: 20.35 β 20.37 Mb
1077:regulation of cell shape
907:adaptive immune response
118:, ANX1, LPC1, annexin A1
2822:10.1126/science.3303336
2707:The Biochemical Journal
1873:estrogen receptor alpha
1642:glucocorticoid receptor
1589:family of Ca-dependent
1570:that is encoded by the
1501:Chr 9: 73.15 β 73.17 Mb
791:lateral plasma membrane
786:early endosome membrane
746:mitochondrial membranes
3704:Intracellular channels
3115:10.1006/geno.1999.5939
3084:10.1074/jbc.274.5.2971
2890:10.1002/pro.5560020317
1007:innate immune response
957:neutrophil homeostasis
937:granulocyte chemotaxis
771:apical plasma membrane
3001:Journal of Immunology
2934:10.1074/jbc.271.2.719
2554:10.1096/fj.06-7464rev
1882:tumor suppressor gene
1687:inflammatory events (
1670:adrenal insufficiency
1605:Clinical significance
1601:inhibitory activity.
1142:peptide cross-linking
1097:response to estradiol
1032:immune system process
1012:inflammatory response
781:extracellular exosome
491:stroma of bone marrow
457:palpebral conjunctiva
341:19 B|19 13.83 cM
302:Chromosome 19 (mouse)
4229:Extracellular matrix
3180:(Annexin A1) at the
3153:genome location and
2074:10.1056/NEJMra050541
1152:neutrophil clearance
1137:DNA duplex unwinding
731:extracellular region
635:phospholipid binding
523:skin of external ear
200:Chromosome 9 (human)
69:List of PDB id codes
42:Available structures
4195:Parathyroid hormone
4183:Indirect regulators
3733:Intracellular pumps
3161:UCSC Genome Browser
2964:1995JMolE..41..979M
2814:1987Sci...237..992B
2686:10.1021/bi00410a024
2656:10.1021/bi00101a015
2306:(9424): 1869β1870.
2006:1986Natur.320...77W
1841:hairy cell leukemia
1679:, thereby blocking
1658:autoimmune diseases
1177:signal transduction
1087:response to hormone
1027:monocyte chemotaxis
962:prolactin secretion
861:extracellular space
856:cytoplasmic vesicle
605:calcium ion binding
527:conjunctival fornix
441:gingival epithelium
4389:, which is in the
4275:Matrix gla protein
4112:Calcium-dependent
4044:Calcium-dependent
4010:Calcium-dependent
3717:Ryanodine receptor
3320:Adhesion molecules
3303:calcium metabolism
2972:10.1007/bf00173179
1753:of blood vessels.
1633:or synthetic anti-
1342:ENSMUSG00000024659
1187:cell-cell adhesion
895:Biological process
756:cornified envelope
704:Cellular component
598:Molecular function
519:tibiofemoral joint
507:epithelium of lens
4381:
4380:
4333:
4332:
4317:Secreted hormones
4290:Bone sialoprotein
4213:
4212:
3676:Second messengers
3660:
3659:
3453:Kainate receptors
3299:calcium signaling
3261:
3260:
3007:(12): 5231β5239.
2808:(4818): 992β998.
2781:Oncogene Research
2756:(17): 8037β8043.
2719:10.1042/bj2630097
2680:(10): 3682β3690.
2650:(37): 9015β9021.
2464:(21): 5238β5248.
2068:(16): 1711β1723.
1708:respiratory burst
1640:that bind to the
1629:) are a class of
1562:, also known as
1557:
1556:
1553:
1552:
1526:
1525:
1491:
1490:
1470:
1469:
1444:
1443:
1423:
1422:
1397:
1396:
1378:
1377:
1348:
1347:
1329:
1328:
1303:
1302:
1284:
1283:
1232:
1231:
1172:response to X-ray
977:insulin secretion
886:synaptic membrane
831:mast cell granule
816:endosome membrane
655:metal ion binding
645:helicase activity
582:
581:
578:
577:
547:
546:
534:
533:
472:
471:
433:mucosa of pharynx
370:
369:
269:
268:
164:ANXA1 - orthologs
96:
95:
92:
91:
52:Ortholog search:
4419:
4338:Calcium-binding
4225:
4103:Protein kinase C
3672:
3425:Calcium channels
3316:
3288:
3281:
3274:
3265:
3247:
3232:
3212:
3205:
3198:
3189:
3126:
3096:
3086:
3077:(5): 2971β2977.
3061:
3051:
3026:
3016:
2991:
2946:
2936:
2911:
2901:
2868:
2858:
2849:(1β2): 347β355.
2833:
2796:
2775:
2765:
2740:
2730:
2697:
2667:
2638:
2628:
2619:(2): 1101β1108.
2603:
2574:
2556:
2531:
2484:
2483:
2473:
2449:
2443:
2442:
2414:
2408:
2407:
2397:
2373:
2367:
2366:
2338:
2332:
2331:
2295:
2289:
2288:
2278:
2261:(6): 2379β2388.
2246:
2240:
2239:
2229:
2197:
2191:
2190:
2180:
2163:(4): 1287β1295.
2148:
2142:
2141:
2105:
2094:
2093:
2057:
2051:
2050:
2043:
2034:
2033:
2014:10.1038/320077a0
1988:
1982:
1981:
1970:
1964:
1963:
1952:
1946:
1936:
1925:
1915:
1720:phospholipase A2
1677:phospholipase A2
1666:immunodeficiency
1638:steroid hormones
1599:phospholipase A2
1539:
1538:
1510:
1503:
1486:
1474:
1465:
1453:
1449:RefSeq (protein)
1439:
1427:
1418:
1406:
1382:
1359:
1333:
1314:
1288:
1269:
1238:
588:
574:
565:
558:
543:
483:
481:Top expressed in
476:
465:nasal epithelium
421:
419:Top expressed in
414:
393:
376:
366:
353:
342:
327:
320:
314:
303:
291:
275:
265:
252:
241:
226:
219:
213:
202:
188:
172:
166:
117:
110:
87:
66:
60:
39:
38:
33:
21:
4427:
4426:
4422:
4421:
4420:
4418:
4417:
4416:
4397:
4396:
4382:
4377:
4368:EGF-like domain
4329:
4311:
4209:
4178:
4107:
4039:
4005:
3778:
3728:
3698:
3656:
3573:
3555:
3525:
3419:
3305:
3292:
3262:
3257:
3254:
3248:
3239:
3233:
3219:
3216:
3134:
3129:
3099:
3064:
3029:
2994:
2949:
2914:
2878:Protein Science
2871:
2836:
2799:
2778:
2743:
2700:
2670:
2641:
2606:
2577:
2534:
2497:
2493:
2491:Further reading
2488:
2487:
2451:
2450:
2446:
2416:
2415:
2411:
2375:
2374:
2370:
2340:
2339:
2335:
2297:
2296:
2292:
2255:Cancer Research
2248:
2247:
2243:
2199:
2198:
2194:
2150:
2149:
2145:
2122:10.1038/nri2470
2107:
2106:
2097:
2059:
2058:
2054:
2045:
2044:
2037:
2000:(6057): 77β81.
1990:
1989:
1985:
1972:
1971:
1967:
1954:
1953:
1949:
1937:
1928:
1916:
1907:
1902:
1853:
1837:
1809:
1803:are inhibited.
1797:Glucocorticoids
1775:
1615:Glucocorticoids
1612:
1607:
1583:
1548:View/Edit Mouse
1543:View/Edit Human
1506:
1499:
1496:Location (UCSC)
1482:
1461:
1435:
1414:
1370:
1323:ENSG00000135046
1216:
890:
796:plasma membrane
741:cell projection
699:
670:protein binding
570:
539:
530:
525:
521:
517:
515:skin of abdomen
513:
509:
505:
501:
497:
493:
479:
468:
463:
459:
455:
453:Achilles tendon
451:
447:
443:
439:
435:
431:
417:
361:
348:
340:
330:
329:
328:
321:
301:
278:Gene location (
260:
247:
239:
229:
228:
227:
220:
198:
175:Gene location (
126:
113:
106:
75:
53:
17:
12:
11:
5:
4425:
4423:
4415:
4414:
4409:
4399:
4398:
4379:
4378:
4376:
4375:
4370:
4365:
4360:
4355:
4350:
4344:
4342:
4335:
4334:
4331:
4330:
4328:
4327:
4321:
4319:
4313:
4312:
4310:
4309:
4308:
4307:
4302:
4297:
4292:
4282:
4277:
4272:
4267:
4266:
4265:
4260:
4255:
4250:
4245:
4234:
4232:
4222:
4218:Extracellular
4215:
4214:
4211:
4210:
4208:
4207:
4202:
4197:
4192:
4186:
4184:
4180:
4179:
4177:
4176:
4175:
4174:
4169:
4164:
4159:
4154:
4149:
4144:
4139:
4134:
4129:
4118:
4116:
4109:
4108:
4106:
4105:
4100:
4099:
4098:
4093:
4088:
4087:
4086:
4081:
4076:
4071:
4061:
4050:
4048:
4041:
4040:
4038:
4037:
4032:
4027:
4022:
4016:
4014:
4007:
4006:
4004:
4003:
4002:
4001:
3996:
3986:
3981:
3976:
3975:
3974:
3969:
3964:
3959:
3954:
3949:
3944:
3939:
3934:
3929:
3924:
3917:Synaptotagmins
3914:
3909:
3904:
3899:
3898:
3897:
3892:
3887:
3882:
3877:
3876:
3875:
3870:
3860:
3855:
3845:
3840:
3835:
3830:
3829:
3828:
3823:
3818:
3813:
3808:
3798:
3792:
3790:
3780:
3779:
3777:
3776:
3775:
3774:
3769:
3759:
3758:
3757:
3752:
3747:
3736:
3734:
3730:
3729:
3727:
3726:
3725:
3724:
3714:
3708:
3706:
3700:
3699:
3697:
3696:
3691:
3686:
3680:
3678:
3669:
3665:Intracellular
3662:
3661:
3658:
3657:
3655:
3654:
3649:
3644:
3639:
3634:
3629:
3624:
3619:
3614:
3609:
3604:
3599:
3594:
3589:
3583:
3581:
3575:
3574:
3572:
3571:
3565:
3563:
3557:
3556:
3554:
3553:
3552:
3551:
3546:
3535:
3533:
3527:
3526:
3524:
3523:
3522:
3521:
3516:
3511:
3501:
3500:
3499:
3494:
3489:
3484:
3479:
3469:
3468:
3467:
3462:
3461:
3460:
3458:NMDA receptors
3455:
3450:
3448:AMPA receptors
3440:
3438:5-HT3 receptor
3429:
3427:
3421:
3420:
3418:
3417:
3416:
3415:
3410:
3405:
3400:
3395:
3390:
3385:
3380:
3375:
3370:
3365:
3360:
3355:
3350:
3345:
3340:
3335:
3324:
3322:
3313:
3307:
3306:
3295:Cell signaling
3293:
3291:
3290:
3283:
3276:
3268:
3259:
3258:
3256:
3255:
3249:
3242:
3240:
3234:
3227:
3224:
3221:
3220:
3217:
3215:
3214:
3207:
3200:
3192:
3186:
3185:
3164:
3145:
3133:
3132:External links
3130:
3128:
3127:
3097:
3062:
3027:
2992:
2958:(6): 979β985.
2947:
2927:(2): 719β725.
2912:
2884:(3): 448β458.
2869:
2834:
2797:
2787:(4): 299β310.
2776:
2741:
2698:
2668:
2639:
2604:
2586:(3): 317β320.
2575:
2547:(4): 968β975.
2532:
2494:
2492:
2489:
2486:
2485:
2444:
2425:(1): 111β117.
2419:Cancer Letters
2409:
2388:(2): 266β274.
2368:
2333:
2290:
2241:
2192:
2143:
2095:
2052:
2035:
1983:
1965:
1947:
1926:
1904:
1903:
1901:
1898:
1852:
1849:
1836:
1833:
1808:
1805:
1787:prostaglandins
1774:
1771:
1724:cyclooxygenase
1712:prostaglandins
1627:beclomethasone
1611:
1608:
1606:
1603:
1582:
1579:
1555:
1554:
1551:
1550:
1545:
1535:
1534:
1528:
1527:
1524:
1523:
1521:
1519:
1512:
1511:
1504:
1497:
1493:
1492:
1489:
1488:
1478:
1477:
1471:
1468:
1467:
1457:
1456:
1450:
1446:
1445:
1442:
1441:
1431:
1430:
1424:
1421:
1420:
1410:
1409:
1403:
1399:
1398:
1395:
1394:
1386:
1385:
1379:
1376:
1375:
1363:
1362:
1356:
1350:
1349:
1346:
1345:
1337:
1336:
1330:
1327:
1326:
1318:
1317:
1311:
1305:
1304:
1301:
1300:
1292:
1291:
1285:
1282:
1281:
1273:
1272:
1266:
1260:
1259:
1254:
1249:
1245:
1244:
1234:
1233:
1230:
1229:
1218:
1217:
1215:
1214:
1209:
1204:
1199:
1194:
1189:
1184:
1179:
1174:
1169:
1164:
1159:
1154:
1149:
1144:
1139:
1134:
1129:
1124:
1119:
1114:
1109:
1104:
1099:
1094:
1089:
1084:
1079:
1074:
1069:
1064:
1059:
1054:
1049:
1044:
1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
898:
896:
892:
891:
889:
888:
883:
878:
873:
871:actin filament
868:
863:
858:
853:
848:
846:phagocytic cup
843:
838:
833:
828:
823:
818:
813:
811:early endosome
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
726:focal adhesion
723:
718:
713:
707:
705:
701:
700:
698:
697:
692:
687:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
627:
622:
617:
612:
607:
601:
599:
595:
594:
584:
583:
580:
579:
576:
575:
567:
566:
555:
549:
548:
545:
544:
536:
535:
532:
531:
529:
528:
524:
520:
516:
512:
508:
504:
503:corneal stroma
500:
496:
492:
488:
485:
484:
473:
470:
469:
467:
466:
462:
458:
454:
450:
449:amniotic fluid
446:
445:body of tongue
442:
438:
434:
430:
426:
423:
422:
410:
409:
401:
390:
384:
383:
380:RNA expression
372:
371:
368:
367:
359:
355:
354:
346:
343:
338:
332:
331:
322:
315:
309:
305:
304:
299:
293:
292:
284:
283:
271:
270:
267:
266:
258:
254:
253:
245:
242:
237:
231:
230:
221:
214:
208:
204:
203:
196:
190:
189:
181:
180:
168:
167:
124:
120:
119:
111:
103:
102:
98:
97:
94:
93:
90:
89:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
4424:
4413:
4410:
4408:
4405:
4404:
4402:
4395:
4394:
4392:
4391:public domain
4388:
4374:
4371:
4369:
4366:
4364:
4361:
4359:
4358:C-type lectin
4356:
4354:
4351:
4349:
4346:
4345:
4343:
4341:
4336:
4326:
4323:
4322:
4320:
4318:
4314:
4306:
4303:
4301:
4298:
4296:
4293:
4291:
4288:
4287:
4286:
4283:
4281:
4278:
4276:
4273:
4271:
4268:
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4246:
4244:
4241:
4240:
4239:
4236:
4235:
4233:
4230:
4226:
4223:
4221:
4216:
4206:
4203:
4201:
4198:
4196:
4193:
4191:
4188:
4187:
4185:
4181:
4173:
4170:
4168:
4165:
4163:
4160:
4158:
4155:
4153:
4150:
4148:
4145:
4143:
4140:
4138:
4135:
4133:
4130:
4128:
4125:
4124:
4123:
4120:
4119:
4117:
4115:
4110:
4104:
4101:
4097:
4094:
4092:
4089:
4085:
4082:
4080:
4077:
4075:
4072:
4070:
4067:
4066:
4065:
4062:
4060:
4057:
4056:
4055:
4052:
4051:
4049:
4047:
4042:
4036:
4033:
4031:
4028:
4026:
4023:
4021:
4018:
4017:
4015:
4013:
4008:
4000:
3997:
3995:
3992:
3991:
3990:
3987:
3985:
3982:
3980:
3977:
3973:
3970:
3968:
3965:
3963:
3960:
3958:
3955:
3953:
3950:
3948:
3945:
3943:
3940:
3938:
3935:
3933:
3930:
3928:
3925:
3923:
3920:
3919:
3918:
3915:
3913:
3910:
3908:
3907:Phospholamban
3905:
3903:
3900:
3896:
3893:
3891:
3888:
3886:
3883:
3881:
3878:
3874:
3871:
3869:
3866:
3865:
3864:
3861:
3859:
3856:
3854:
3851:
3850:
3849:
3846:
3844:
3841:
3839:
3836:
3834:
3833:Calsequestrin
3831:
3827:
3824:
3822:
3819:
3817:
3814:
3812:
3809:
3807:
3804:
3803:
3802:
3799:
3797:
3794:
3793:
3791:
3789:
3785:
3781:
3773:
3770:
3768:
3765:
3764:
3763:
3760:
3756:
3753:
3751:
3748:
3746:
3743:
3742:
3741:
3738:
3737:
3735:
3731:
3723:
3720:
3719:
3718:
3715:
3713:
3710:
3709:
3707:
3705:
3701:
3695:
3692:
3690:
3687:
3685:
3682:
3681:
3679:
3677:
3673:
3670:
3668:
3663:
3653:
3650:
3648:
3645:
3643:
3640:
3638:
3635:
3633:
3630:
3628:
3625:
3623:
3620:
3618:
3615:
3613:
3610:
3608:
3605:
3603:
3600:
3598:
3595:
3593:
3590:
3588:
3585:
3584:
3582:
3580:
3576:
3570:
3567:
3566:
3564:
3562:
3558:
3550:
3547:
3545:
3542:
3541:
3540:
3537:
3536:
3534:
3532:
3531:Calcium pumps
3528:
3520:
3517:
3515:
3512:
3510:
3507:
3506:
3505:
3502:
3498:
3495:
3493:
3490:
3488:
3485:
3483:
3480:
3478:
3475:
3474:
3473:
3472:Voltage-gated
3470:
3466:
3465:P2X receptors
3463:
3459:
3456:
3454:
3451:
3449:
3446:
3445:
3444:
3441:
3439:
3436:
3435:
3434:
3431:
3430:
3428:
3426:
3422:
3414:
3411:
3409:
3406:
3404:
3401:
3399:
3396:
3394:
3391:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
3364:
3361:
3359:
3356:
3354:
3351:
3349:
3346:
3344:
3341:
3339:
3336:
3334:
3331:
3330:
3329:
3326:
3325:
3323:
3321:
3317:
3314:
3312:
3311:Cell membrane
3308:
3304:
3300:
3296:
3289:
3284:
3282:
3277:
3275:
3270:
3269:
3266:
3252:
3246:
3241:
3237:
3231:
3226:
3222:
3213:
3208:
3206:
3201:
3199:
3194:
3193:
3190:
3183:
3179:
3178:
3173:
3169:
3165:
3162:
3158:
3157:
3152:
3151:
3146:
3143:
3139:
3136:
3135:
3131:
3124:
3120:
3116:
3112:
3108:
3104:
3098:
3094:
3090:
3085:
3080:
3076:
3072:
3068:
3063:
3059:
3055:
3050:
3045:
3041:
3037:
3033:
3028:
3024:
3020:
3015:
3010:
3006:
3002:
2998:
2993:
2989:
2985:
2981:
2977:
2973:
2969:
2965:
2961:
2957:
2953:
2948:
2944:
2940:
2935:
2930:
2926:
2922:
2918:
2913:
2909:
2905:
2900:
2895:
2891:
2887:
2883:
2879:
2875:
2870:
2866:
2862:
2857:
2852:
2848:
2844:
2840:
2835:
2831:
2827:
2823:
2819:
2815:
2811:
2807:
2803:
2798:
2794:
2790:
2786:
2782:
2777:
2773:
2769:
2764:
2759:
2755:
2751:
2747:
2742:
2738:
2734:
2729:
2724:
2720:
2716:
2713:(1): 97β103.
2712:
2708:
2704:
2699:
2695:
2691:
2687:
2683:
2679:
2675:
2669:
2665:
2661:
2657:
2653:
2649:
2645:
2640:
2636:
2632:
2627:
2622:
2618:
2614:
2610:
2605:
2601:
2597:
2593:
2589:
2585:
2581:
2576:
2572:
2568:
2564:
2560:
2555:
2550:
2546:
2542:
2541:FASEB Journal
2538:
2533:
2529:
2525:
2521:
2517:
2513:
2509:
2505:
2501:
2496:
2495:
2490:
2481:
2477:
2472:
2467:
2463:
2459:
2455:
2448:
2445:
2440:
2436:
2432:
2428:
2424:
2420:
2413:
2410:
2405:
2401:
2396:
2391:
2387:
2383:
2379:
2372:
2369:
2364:
2360:
2356:
2352:
2348:
2344:
2337:
2334:
2329:
2325:
2321:
2317:
2313:
2309:
2305:
2301:
2294:
2291:
2286:
2282:
2277:
2272:
2268:
2264:
2260:
2256:
2252:
2245:
2242:
2237:
2233:
2228:
2223:
2219:
2215:
2211:
2207:
2203:
2196:
2193:
2188:
2184:
2179:
2174:
2170:
2166:
2162:
2158:
2154:
2147:
2144:
2139:
2135:
2131:
2127:
2123:
2119:
2115:
2111:
2104:
2102:
2100:
2096:
2091:
2087:
2083:
2079:
2075:
2071:
2067:
2063:
2056:
2053:
2048:
2042:
2040:
2036:
2031:
2027:
2023:
2019:
2015:
2011:
2007:
2003:
1999:
1995:
1987:
1984:
1979:
1975:
1969:
1966:
1961:
1957:
1951:
1948:
1944:
1940:
1935:
1933:
1931:
1927:
1923:
1919:
1914:
1912:
1910:
1906:
1899:
1897:
1895:
1890:
1885:
1883:
1878:
1874:
1870:
1866:
1862:
1857:
1851:Breast cancer
1850:
1848:
1846:
1842:
1834:
1832:
1830:
1826:
1822:
1818:
1814:
1806:
1804:
1802:
1798:
1794:
1792:
1788:
1784:
1780:
1772:
1770:
1766:
1764:
1763:extravasation
1760:
1756:
1752:
1748:
1744:
1740:
1736:
1731:
1729:
1725:
1721:
1717:
1713:
1709:
1705:
1701:
1697:
1693:
1690:
1686:
1682:
1678:
1673:
1671:
1667:
1663:
1659:
1655:
1651:
1647:
1643:
1639:
1636:
1632:
1628:
1624:
1620:
1616:
1609:
1604:
1602:
1600:
1596:
1592:
1588:
1580:
1578:
1576:
1573:
1569:
1565:
1561:
1549:
1544:
1540:
1536:
1533:
1529:
1522:
1520:
1517:
1513:
1509:
1505:
1502:
1498:
1494:
1487:
1485:
1479:
1475:
1472:
1466:
1464:
1458:
1454:
1451:
1447:
1440:
1438:
1432:
1428:
1425:
1419:
1417:
1411:
1407:
1404:
1402:RefSeq (mRNA)
1400:
1393:
1392:
1387:
1383:
1380:
1374:
1373:
1369:
1364:
1360:
1357:
1355:
1351:
1344:
1343:
1338:
1334:
1331:
1325:
1324:
1319:
1315:
1312:
1310:
1306:
1299:
1298:
1293:
1289:
1286:
1280:
1279:
1274:
1270:
1267:
1265:
1261:
1258:
1255:
1253:
1250:
1246:
1243:
1239:
1235:
1228:
1224:
1219:
1213:
1210:
1208:
1205:
1203:
1200:
1198:
1195:
1193:
1190:
1188:
1185:
1183:
1180:
1178:
1175:
1173:
1170:
1168:
1165:
1163:
1160:
1158:
1155:
1153:
1150:
1148:
1145:
1143:
1140:
1138:
1135:
1133:
1130:
1128:
1127:DNA rewinding
1125:
1123:
1120:
1118:
1115:
1113:
1110:
1108:
1105:
1103:
1100:
1098:
1095:
1093:
1090:
1088:
1085:
1083:
1080:
1078:
1075:
1073:
1070:
1068:
1065:
1063:
1060:
1058:
1055:
1053:
1050:
1048:
1045:
1043:
1040:
1038:
1035:
1033:
1030:
1028:
1025:
1023:
1020:
1018:
1015:
1013:
1010:
1008:
1005:
1003:
1000:
998:
995:
993:
990:
988:
985:
983:
980:
978:
975:
973:
970:
968:
965:
963:
960:
958:
955:
953:
950:
948:
945:
943:
940:
938:
935:
933:
930:
928:
925:
923:
920:
918:
915:
913:
912:estrous cycle
910:
908:
905:
903:
900:
899:
897:
894:
893:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
776:motile cilium
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
708:
706:
703:
702:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
602:
600:
597:
596:
593:
592:Gene ontology
589:
585:
573:
568:
564:
559:
556:
554:
550:
542:
537:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
489:
486:
482:
477:
474:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
427:
424:
420:
415:
412:
411:
408:
406:
402:
400:
399:
395:
394:
391:
389:
385:
381:
377:
373:
365:
360:
356:
352:
347:
337:
333:
326:
319:
313:
306:
298:
294:
290:
285:
281:
276:
272:
264:
259:
255:
251:
246:
236:
232:
225:
218:
212:
205:
201:
195:
191:
187:
182:
178:
173:
169:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
121:
116:
109:
104:
99:
88:
86:
82:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
4384:
4383:
4270:Hemicentin 1
4020:Calreticulin
3912:Sarcalumenin
3712:IP3 receptor
3586:
3504:TRP channels
3433:Ligand-gated
3250:
3235:
3175:
3155:
3149:
3106:
3102:
3074:
3070:
3042:(1): 39β51.
3039:
3035:
3004:
3000:
2955:
2951:
2924:
2920:
2881:
2877:
2846:
2842:
2805:
2801:
2784:
2780:
2753:
2749:
2710:
2706:
2677:
2674:Biochemistry
2673:
2647:
2644:Biochemistry
2643:
2616:
2612:
2583:
2579:
2544:
2540:
2503:
2499:
2461:
2457:
2447:
2422:
2418:
2412:
2385:
2381:
2371:
2346:
2342:
2336:
2303:
2299:
2293:
2258:
2254:
2244:
2212:(1): 66β72.
2209:
2205:
2195:
2160:
2156:
2146:
2116:(1): 62β70.
2113:
2109:
2065:
2061:
2055:
1997:
1993:
1986:
1977:
1968:
1959:
1950:
1886:
1859:Exposure of
1858:
1854:
1838:
1810:
1795:
1791:leukotrienes
1783:inflammation
1779:biosynthesis
1776:
1773:Inflammation
1767:
1758:
1754:
1732:
1716:leukotrienes
1704:phagocytosis
1674:
1635:inflammatory
1613:
1591:phospholipid
1584:
1571:
1564:lipocortin I
1563:
1559:
1558:
1481:
1460:
1434:
1413:
1389:
1366:
1340:
1321:
1295:
1276:
1256:
1251:
1002:phagocytosis
761:cell surface
403:
396:
123:External IDs
74:
18:
4325:Osteocalcin
4305:Osteopontin
4280:Osteonectin
4054:CaM kinases
3902:Parvalbumin
3885:Neurocalcin
3880:Hippocalcin
3218:PDB gallery
3109:(1): 5β14.
2349:: 278β288.
1801:eicosanoids
1751:endothelium
1743:macrophages
1735:neutrophils
1577:in humans.
947:gliogenesis
806:nucleoplasm
495:granulocyte
429:oral cavity
362:20,368,308
349:20,350,792
261:73,170,393
248:73,151,865
101:Identifiers
4401:Categories
4373:Gla domain
4190:Calcitonin
4012:chaperones
3989:Troponin C
3853:Calsenilin
3838:Calretinin
3801:Calmodulin
3138:Annexin+A1
2506:(1): 1β3.
1945:, May 2017
1924:, May 2017
1900:References
1889:DNA damage
1813:anticancer
1700:chemotaxis
1696:emigration
1689:epithelial
1681:eicosanoid
1646:vertebrate
1631:endogenous
1619:budesonide
1560:Annexin A1
841:sarcolemma
499:belly cord
407:(ortholog)
144:HomoloGene
4348:C2 domain
4220:chelators
4205:Vitamin K
4200:Vitamin D
4114:proteases
3890:Recoverin
3858:Frequenin
3796:Calbindin
3788:chelators
3667:signaling
3328:Cadherins
1831:subunit.
1825:apoptosis
1747:cytoplasm
1739:monocytes
1685:leukocyte
1650:allergies
1617:(such as
1595:cytosolic
1484:NP_034860
1463:NP_000691
1437:NM_010730
1416:NM_000700
1242:Orthologs
711:cytoplasm
152:GeneCards
4353:Cadherin
4285:SIBLINGs
4238:Fibulins
4231:proteins
4122:Calpains
4025:Calnexin
3843:Gelsolin
3579:Annexins
3123:10512675
3103:Genomics
2988:12365687
2563:17215481
2528:29849223
2480:27172896
2439:20163912
2404:19208747
2363:28212890
2328:25641077
2320:15183626
2285:20215502
2138:29352038
2130:19104500
2082:16236742
1941:–
1920:–
1865:estrogen
1835:Leukemia
1755:In vitro
1692:adhesion
1623:cortisol
1581:Function
1532:Wikidata
1221:Sources:
721:membrane
716:endosome
4363:EF hand
4340:domains
4046:kinases
4035:HSP90B1
3895:Visinin
3784:Sensors
3772:SLC24A5
3182:PDBe-KB
3172:UniProt
3093:9915835
3058:9459484
3023:8955167
2980:8587144
2960:Bibcode
2943:8557678
2908:8453382
2899:2142391
2865:8425544
2830:3303336
2810:Bibcode
2802:Science
2793:2969496
2772:2967291
2737:2532504
2728:1133395
2694:2457390
2664:1832554
2635:1670773
2600:1602151
2571:7273321
2520:2971450
2276:2953961
2236:8428216
2227:1907693
2187:2514948
2178:1854794
2090:5744727
2030:4332606
2022:2936963
2002:Bibcode
1943:Ensembl
1922:Ensembl
1759:in vivo
1587:annexin
1568:protein
1566:, is a
1354:UniProt
1309:Ensembl
1248:Species
1227:QuickGO
866:cytosol
826:vesicle
736:nucleus
382:pattern
240:9q21.13
108:Aliases
4172:CAPN10
3826:CALML5
3821:CALML3
3767:SLC8B1
3755:ATP2A3
3750:ATP2A2
3745:ATP2A1
3549:SLC8A1
3544:SLC3A2
3177:P04083
3147:Human
3144:(MeSH)
3121:
3091:
3056:
3021:
2986:
2978:
2941:
2906:
2896:
2863:
2828:
2791:
2770:
2735:
2725:
2692:
2662:
2633:
2598:
2569:
2561:
2526:
2518:
2478:
2437:
2402:
2361:
2326:
2318:
2300:Lancet
2283:
2273:
2234:
2224:
2185:
2175:
2136:
2128:
2088:
2080:
2028:
2020:
1994:Nature
1894:ARID1A
1817:NSAIDS
1807:Cancer
1789:, and
1741:, and
1728:NSAIDs
1662:sepsis
1660:, and
1654:asthma
1625:, and
1518:search
1516:PubMed
1391:P10107
1372:Q5T3N0
1368:P04083
1264:Entrez
751:cilium
553:BioGPS
132:151690
4263:FBLN5
4258:FBLN4
4253:FBLN3
4248:FBLN2
4243:FBLN1
4167:CAPN9
4162:CAPN8
4157:CAPN7
4152:CAPN6
4147:CAPN5
4142:CAPN4
4137:CAPN3
4132:CAPN2
4127:CAPN1
4096:CAMK4
4091:CAMK3
4064:CAMK2
4059:CAMK1
4030:HSPA5
3999:TNNC2
3994:TNNC1
3984:S100P
3972:SYT14
3967:SYT13
3962:SYT11
3816:CALM3
3811:CALM2
3806:CALM1
3740:SERCA
3694:cADPR
3689:NAADP
3627:A8-L2
3561:GPCRs
3413:CDH17
3408:CDH16
3403:CDH15
3398:CDH14
3393:CDH13
3388:CDH12
3383:CDH11
3378:CDH10
3156:ANXA1
3150:ANXA1
2984:S2CID
2567:S2CID
2524:S2CID
2324:S2CID
2134:S2CID
2086:S2CID
2026:S2CID
1877:siRNA
1861:MCF-7
1845:assay
1821:NF-ΞΊB
1572:ANXA1
1297:16952
1257:Mouse
1252:Human
1223:Amigo
405:Mouse
398:Human
345:Start
280:Mouse
244:Start
177:Human
156:ANXA1
140:96819
115:ANXA1
24:ANXA1
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