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205:. She studies mutations – the origin of all genetic variations. By investigating and understanding mutations, Goriely aims to better understand disease and evolution. As mutations arise from random miscopying events and are mainly from the paternal germline, Goriely has studied mutations and the regulation of cell fates in male germline stem cells. She primarily makes use of
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756:(1 September 2003). "Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension".
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565:""Selfish spermatogonial selection": a novel mechanism for the association between advanced paternal age and neurodevelopmental disorders"
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Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension
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they spontaneously occur at high levels compared to background rates of mutation. She showed that pathways included the
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818:"Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease"
649:"Paternal Age Effect Mutations and Selfish Spermatogonial Selection: Causes and Consequences for Human Disease"
563:
Goriely, Anne; McGrath, John J.; Hultman, Christina M.; Wilkie, Andrew O.M.; Malaspina, Dolores (2013-06-01).
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Paternal age effect mutations and selfish spermatogonial selection: causes and consequences for human disease
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Selection" to describe the link between paternal age and neurodevelopment disorders. These disorders include
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signalling cascade. She has shown that these molecular pathways are implicated in other cellular contexts.
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as men age and are likely to be transferred to future generations. She coined the phrase "Selfish
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Factors influencing success of clinical genome sequencing across a broad spectrum of disorders
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Goriely showed that pathogenic mutations hijack stem production, become enriched in the
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is likely to impact all men as they age, and can increase predisposition to
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Jenny C Taylor; Hilary C Martin; Stefano Lise; et al. (18 May 2015).
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706:"Increased paternal age may give rise to disease in the new generation"
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540:"Goriely Group: Clinical genetics — Radcliffe Department of Medicine"
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127:. Her research investigates the molecular mechanisms that underpin
201:. She remained in Oxford to establish her own research group in
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disorders, and demonstrated that due to principles similar to
236:. Goriely has argued that more attention needs to be paid to
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647:Goriely, Anne; Wilkie, Andrew O. M. (2012-02-10).
748:Ruth Diez del Corral; Isabel Olivera-Martinez;
448:. The Evolution and Medicine Review. 2014-05-03
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119:is a Belgian geneticist who is a professor of
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155:. Her doctoral research investigated the
147:Goriely was an undergraduate student in
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267:and neurodevelopment disorders such as
169:. She was a graduate researcher at the
653:The American Journal of Human Genetics
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910:21st-century British women scientists
905:20th-century British women scientists
900:Academics of the University of Oxford
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895:Université libre de Bruxelles alumni
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823:American Journal of Human Genetics
569:The American Journal of Psychiatry
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261:Selfish Spermatogonial Selection
930:21st-century British scientists
925:20th-century British scientists
16:British geneticist and academic
581:10.1176/appi.ajp.2013.12101352
1:
772:10.1016/S0896-6273(03)00565-8
752:; Emily Gale; Malcolm Maden;
153:Université libre de Bruxelles
33:Université libre de Bruxelles
731:publications indexed by the
189:In 2000, Goriely joined the
243:Goriely describes these as
946:
836:10.1016/J.AJHG.2011.12.017
665:10.1016/j.ajhg.2011.12.017
620:Lyons, Kate (2016-03-19).
279:Her publications include:
920:British women geneticists
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735:bibliographic database.
320:publications indexed by
143:Early life and education
737:(subscription required)
195:postdoctoral researcher
177:. She is the sister of
166:Drosophila melanogaster
389:"SFARI | Anne Goriely"
253:growth factor-receptor
175:Rockefeller University
171:Weill Cornell Medicine
76:Weill Cornell Medicine
72:Rockefeller University
345:Europe PubMed Central
275:Selected publications
157:developmental biology
816:(10 February 2012).
442:"Germline Selection"
421:simonsfoundation.org
191:University of Oxford
125:University of Oxford
68:University of Oxford
915:British geneticists
754:Kate Gillian Storey
704:Anon (2022-11-08).
245:paternal age effect
185:Research and career
343:publications from
207:genetic sequencing
814:Andrew O M Wilkie
234:Costello syndrome
203:clinical genetics
163:in the fruit fly
129:genetic variation
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40:Scientific career
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161:nervous systems
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575:(6): 599–608.
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483:(7): 717–726.
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417:"Anne Goriely"
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360:"Anne Goriely"
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322:Google Scholar
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238:male fertility
226:Achondroplasia
222:Apert syndrome
218:Spermatogonial
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810:Anne Goriely
809:
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766:(1): 65–79.
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750:Anne Goriely
749:
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729:Anne Goriely
724:
713:. Retrieved
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631:. Retrieved
627:The Guardian
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547:. Retrieved
544:rdm.ox.ac.uk
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450:. Retrieved
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423:. 2021-10-08
420:
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395:. 2017-07-21
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367:. Retrieved
364:rdm.ox.ac.uk
363:
341:Anne Goriely
318:Anne Goriely
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135:in the male
117:Anne Goriely
116:
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64:Institutions
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23:Anne Goriely
257:RAS protein
249:oncogenesis
54:Development
884:Categories
715:2022-12-14
633:2022-12-14
549:2022-12-14
452:2022-12-14
427:2022-12-14
399:2022-12-14
369:2022-12-14
300:References
870:Q28259472
844:0002-9297
796:Q44607276
780:0896-6273
673:0002-9297
589:0002-953X
523:Q36147983
497:1061-4036
393:sfari.org
133:mutations
58:Mutations
866:Wikidata
862:22325359
792:Wikidata
788:14527434
691:22325359
607:23639989
519:Wikidata
515:25985138
149:agronomy
137:germline
50:Genetics
853:3276674
682:3276674
598:4001324
506:4601524
151:at the
123:at the
101:/people
86:Website
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733:Scopus
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265:cancer
214:testis
46:Fields
197:with
193:as a
858:PMID
840:ISSN
784:PMID
776:ISSN
687:PMID
669:ISSN
603:PMID
585:ISSN
511:PMID
493:ISSN
232:and
173:and
93:.rdm
848:PMC
832:doi
768:doi
677:PMC
661:doi
593:PMC
577:doi
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501:PMC
485:doi
159:of
99:.uk
97:.ac
95:.ox
91:www
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