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264:
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compartments may underlie amyotrophic lateral sclerosis (ALS) and other neurodegenerative and age-related diseases. Hyman's current work focuses on the physical-chemical basis by which intrinsically disordered proteins phase separate. Using this knowledge, he is studying the roles of phase separation in physiology and disease.
478:
to define the "parts lists" for different cytoplasmic processes. And in 2009, he, together with Cliff
Brangwynne and Frank Julicher, made a fundamental breakthrough by being the first to observe that compartments in cells can form by phase separation. Aberrant phase transitions within liquid-like
751:
Gönczy, P; Echeverri, C; Oegema, K; Coulson, A; Jones, S. J.; Copley, R. R.; Duperon, J; Oegema, J; Brehm, M; Cassin, E; Hannak, E; Kirkham, M; Pichler, S; Flohrs, K; Goessen, A; Leidel, S; Alleaume, A. M.; Martin, C; Ozlü, N; Bork, P; Hyman, A. A. (2000). "Functional genomic analysis of cell
370:
group. Using microscopy and microsurgery, he examined the placement of cell axes during early cell division of C.elegans embryos. Hyman presented new findings about mechanisms of rotation by cutting microtubules with a laser beam. Hyman demonstrated that pulling forces acting from the
420:(EMBL) Hyman along with Rebecca Heald and Eric Karsenti combined their work to create an impact on the current understanding of how the meiotic spindle self assembles. Hyman created his first independent group at EMBL that discovered that the important factors in
473:
Hyman is currently studying the mechanisms by which cells compartmentalize their biochemistry. Of his many contributions to the field of molecular biology, he is best known for two discoveries in particular: In 2000, his team pioneered the use of
1132:
Heald, R; Tournebize, R; Blank, T; Sandaltzopoulos, R; Becker, P; Hyman, A; Karsenti, E (1996). "Self-organization of microtubules into bipolar spindles around artificial chromosomes in
Xenopus egg extracts".
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for discovering a fundamental mechanism of cellular organization mediated by phase separation of proteins and RNA into membraneless liquid droplets.
2082:
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Tournebize, R; Popov, A; Kinoshita, K; Ashford, A. J.; Rybina, S; Pozniakovsky, A; Mayer, T. U.; Walczak, C. E.; Karsenti, E; Hyman, A. A. (2000).
51:
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and was the
Managing Director for the institute from 2010–2013. During his tenure at the MPI-CBG, Hyman and his lab members have focused on:
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210:
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Hyman, A. A.; Mitchison, T. J. (1991). "Two different microtubule-based motor activities with opposite polarities in kinetochores".
847:
1666:
535:
502:, Germany's most prestigious research award, for his work on microtubules and cell division. Hyman was elected a Member of the
499:
281:
164:
40:
1639:"Breakthrough Prize – Winners Of The 2023 Breakthrough Prizes In Life Sciences, Mathematics And Fundamental Physics Announced"
2097:
22:
518:. In 2020, he was given the NOMIS Distinguished Scientist Award by the NOMIS Foundation. Hyman was elected Member of the
1828:
519:
314:
1543:
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and he was elected a member of the German
National Academy of Sciences Leopoldina in 2021. In 2022, Hyman received the
1709:
507:
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36:
353:. Hyman's research has identified how microtubules are made into cellular structures and how they are broken down.
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1803:
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864:
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Hyman has worked on creating parts lists for cell division among human cells as part of the EU funded projects
1042:"Preparation of marked microtubules for the assay of the polarity of microtubule-based motors by fluorescence"
802:
1186:"Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts"
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951:"Role of GTP hydrolysis in microtubule dynamics: Information from a slowly hydrolyzable analogue, GMPCPP"
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Hyman, A; Drechsel, D; Kellogg, D; Salser, S; Sawin, K; Steffen, P; Wordeman, L; Mitchison, T (1991).
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655:"Anthony Hyman: From unlikely scientist to Royal Society Fellow. Interview by Ruth Williams"
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2004:
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902:"Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans"
346:
170:
158:
866:
Establishment of division axes in the early embryonic divisions of
Caenorhabditis elegans
617:
514:
elected Hyman as a member in 2014 and in 2017, he received the
Schleiden Medal from the
237:
Establishment of division axes in the early embryonic divisions of
Caenorhabditis Elegans
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and microtubules that create the mitotic forces that separate chromosomes in the lab of
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Hyman, A. A.; Salser, S; Drechsel, D. N.; Unwin, N; Mitchison, T. J. (1992).
878:
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Hyman served as a member of the
Strategic Advisory Board on Science at the
439:
Cytoplasmic organization and how cells form non-membrane bound compartments
1947:
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While at King's
College, Cambridge, Hyman worked under the supervision of
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Philosophical
Transactions of the Royal Society B: Biological Sciences
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78:
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in 2000 and was awarded its Gold Medal in 2003. He was elected a
494:
Anthony Hyman is honorary professor at the Faculty of Biology at
1544:"Dewpoint Co-Founder Anthony Hyman Wins Prestigious Wiley Prize"
1682:
752:
division in C. Elegans using RNAi of genes on chromosome III".
526:
for his work on biomolecular condensates. He received the 2021
1235:"Max Planck Institute of Molecular Cell Biology and Genetics"
814:
Anthony Hyman's Brief Overview: "Visualizing Plus-end Growth"
1255:
522:
in April 2020. In February 2021, Hyman was awarded the 2021
431:
In 1999, Hyman became one of the four founding directors of
433:
Max Planck Institute of Molecular Cell Biology and Genetics
287:
Max Planck Institute of Molecular Cell Biology and Genetics
221:
Max Planck Institute of Molecular Cell Biology and Genetics
1276:
390:. He also created a number of tools that are used today:
1002:. Methods in Enzymology. Vol. 196. pp. 478–85.
297:
Hyman was born in 1962, the eldest of three children of
256:
1352:"DFG Leibniz Prize Winner: Prof. Dr. Anthony A. Hyman"
825:
Video on Anthony A. Hyman's research (Latest Thinking)
1295:
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803:
Anthony Hyman's seminars: "Organization of Cytoplasm"
2018:
1967:
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57:
30:
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305:, and Hon. Laura Alice Boyd, daughter of the 6th
516:German National Academy of Sciences Leopoldina
504:European Molecular Biology Organization (EMBO)
1694:
1665:. In: ASCB-Newsletter, November 2012, S. 41 (
382:, Hyman investigated the interaction between
8:
424:egg extracts were the stabilizing protein,
285:is a British scientist and director at the
21:For other people called Anthony Hyman, see
1701:
1687:
1679:
624:
554:(1959–2019); the couple had two children.
333:Hyman has focused his career on examining
262:
49:
27:
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1373:"EMBO Gold Medalists – Recipients – EMBO"
1057:
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727:
678:
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375:on microtubules drives spindle rotation.
550:Hyman was married to American scientist
2068:People educated at William Ellis School
2053:Gottfried Wilhelm Leibniz Prize winners
1444:"New members of Academia Europaea 2014"
873:(PhD thesis). University of Cambridge.
592: ed.). A & C Black.
563:
380:University of California, San Francisco
216:University of California, San Francisco
1301:"Anthony Hyman – The NOMIS Foundation"
428:and the destabilizing protein, XKCM1.
325:, where he was awarded a PhD in 1987.
418:European Molecular Biology Laboratory
211:European Molecular Biology Laboratory
7:
598:10.1093/ww/9780199540884.013.U250063
2093:Alumni of King's College, Cambridge
2088:Alumni of University College London
1046:Journal of Cell Science. Supplement
900:Hyman, A. A.; White, J. G. (1987).
842:. eBook Partnership. p. 2547.
540:Breakthrough Prize in Life Sciences
456:Spatial control of the microtubule
177:Breakthrough Prize in Life Sciences
1519:"Biomedical Sciences | Prize"
538:2022. For 2023 he was awarded the
524:Wiley Prize in Biomedical Sciences
14:
1327:"Science Strategy Advisory Group"
1059:10.1242/jcs.1991.supplement_14.25
508:Fellow of the Royal Society (FRS)
498:. In 2011, Hyman was awarded the
1000:Preparation of modified tubulins
839:Debrett's Peerage and Baronetage
337:and how these structures of the
2083:21st-century British biologists
2078:20th-century British biologists
500:Gottfried Wilhelm Leibniz Prize
2108:Max Planck Institute directors
1574:Human Frontier Science Program
23:Anthony Hyman (disambiguation)
1:
955:Molecular Biology of the Cell
536:Körber European Science Prize
2073:Fellows of the Royal Society
1498:National Academy of Sciences
1008:10.1016/0076-6879(91)96041-o
863:Hyman, Anthony Arie (1987).
605:UK public library membership
520:National Academy of Sciences
360:and was a key researcher in
315:St Marylebone Grammar School
906:The Journal of Cell Biology
659:The Journal of Cell Biology
579:"Hyman, Prof. Anthony Arie"
2124:
2103:Schleiden Medal recipients
462:Positioning of the spindle
20:
1413:10.1016/j.cub.2011.02.010
704:"Whither systems biology"
319:University College London
247:
186:
112:University College London
48:
1663:ASCB Profile: Tony Hyman
1613:"Portrait Anthony Hyman"
1570:"HFSP Nakasone Awardees"
620:publications indexed by
442:Size and scaling of the
293:Early life and education
1879:Robert Mair, Baron Mair
590:Oxford University Press
323:University of Cambridge
118:University of Cambridge
1942:Veronica van Heyningen
1256:"MitoCheck Consortium"
918:10.1083/jcb.105.5.2123
836:Morris, Susan (2019).
720:10.1098/rstb.2011.0074
408:assays for motors and
394:atypical hydrolysable
367:Caenorhabditis elegans
303:historian of computing
198:Molecular Cell Biology
2098:Scientists from Haifa
1643:breakthroughprize.org
1040:Hyman, A. A. (1991).
967:10.1091/mbc.3.10.1155
702:Hyman, A. A. (2011).
642:Europe PubMed Central
309:. He was educated at
1995:Jeremiah P. Ostriker
1932:David C. Sherrington
1910:Edward Arend Perkins
1277:"MitoSys Consortium"
401:various fluorescent
311:William Ellis School
99:William Ellis School
1494:"2020 NAS Election"
1193:Nature Cell Biology
1147:1996Natur.382..420H
1095:1991Natur.351..206H
766:2000Natur.408..331G
714:(1584): 3635–3637.
532:Clifford Brangwynne
528:HFSP Nakasone Award
329:Career and research
275:(born 27 May 1962)
1799:George F. R. Ellis
1550:. Associated Press
1394:Hyman, T. (2011).
1305:nomisfoundation.ch
887:uk.bl.ethos.256630
671:10.1083/jcb.1797pi
640:publications from
490:Awards and honours
273:Anthony Arie Hyman
62:Anthony Arie Hyman
2034:
2033:
1874:Ravinder N. Maini
1588:"List of members"
1448:Academia Europaea
1017:978-0-12-182097-8
653:Hyman, A (2007).
603:(Subscription or
512:Academia Europaea
270:
269:
188:Scientific career
18:British biologist
2115:
2000:Michael O. Rabin
1975:Wallace Broecker
1959:Andrew Zisserman
1869:Peter Littlewood
1839:Anthony A. Hyman
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1406:(7): R240–R242.
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1375:. 20 August 2020
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1089:(6323): 206–11.
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476:RNA interference
373:posterior cortex
307:Baron Kilmarnock
299:R. Anthony Hyman
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2005:Gerald M. Rubin
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1905:John A. Peacock
1859:Ottoline Leyser
1844:Anthony Kinloch
1834:Nicholas Higham
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1783:Richard Cogdell
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1307:. 13 April 2020
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105:Alma mater
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1990:Tom Fenchel
1937:Terence Tao
1864:Paul Linden
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1528:11 February
1379:11 February
1336:11 February
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452:organelles
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