1247:, where one testis fails to descend outside of the body cavity. The majority of these patients will be infertile. In females that are homozygous for the mutation, no abnormalities have been observed. However, heterozygous females have been observed to reach menopause sooner and display a lowered AMH level which also is an indicator of antral follicle count. It is likely that these females reach menopause sooner from having fewer antral follicles, thus more atresia of follicles prior to developing an antrum. These phenotypes were confirmed to be the cause of an AMHR2 mutation from knock out studies performed in mice.
1159:
299:
276:
173:
198:
305:
204:
5241:
1196:. It has been reported that the loss of function of the AMHR2 gene results in 50% of XY animals to reverse sex to females and also leads to hyperproliferation of mitotically active germ cells, which leads to the sex reversal. AMH binding to the AMHR2 in mammals causes regression of the oviducts, uterus, and upper 2/3 of the vagina.
27:
1187:
is present in both men and women. AMHR2 is a Type 2 receptor that binds AMH (Anti-Müllerian hormone). This hormone is responsible for Müllerian Duct regression in vertebrates once the SRY gene has been expressed. Some animals such as jawless fish do not express either AMH or its receptors. High
1174:
fold. However, it displays a unique extended finger 1 loop (see image) that is critical to effectively binding its ligand, AMH. The palm region and other fingers are also implicated in binding to AMH, but are relatively unremarkable when compared to other TGF-β type II receptors. As such, these
1529:
Masiakos PT, MacLaughlin DT, Maheswaran S, Teixeira J, Fuller AF, Shah PC, et al. (November 1999). "Human ovarian cancer, cell lines, and primary ascites cells express the human
Mullerian inhibiting substance (MIS) type II receptor, bind, and are responsive to MIS".
2058:
Bakkum-Gamez JN, Aletti G, Lewis KA, Keeney GL, Thomas BM, Navarro-Teulon I, Cliby WA (January 2008). "Müllerian inhibiting substance type II receptor (MISIIR): a novel, tissue-specific target expressed by gynecologic cancers".
3104:
1234:
A syndrome called "Persistent
Mullerian Duct Syndrome" (PMDS) can occur in human males and results in the uterus, vagina, and uterus being present in virilized male. PMDS can be caused by a genetic mutation of
3389:
1437:
Adolfi MC, Nakajima RT, Nóbrega RH, Schartl M (February 2019). "Intersex, Hermaphroditism, and
Gonadal Plasticity in Vertebrates: Evolution of the Müllerian Duct and Amh/Amhr2 Signaling".
3097:
45:
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3297:
312:
211:
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1842:"Mutational analysis of the müllerian-inhibiting substance gene and its receptor gene in Japanese women with polycystic ovary syndrome and premature ovarian failure"
1616:"Development of engineered antibodies specific for the Müllerian inhibiting substance type II receptor: a promising candidate for targeted therapy of ovarian cancer"
2807:
1955:"Anti-Müllerian hormone and anti-Müllerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women"
1920:"Anti-Müllerian hormone and anti-Müllerian hormone type II receptor polymorphisms are associated with follicular phase estradiol levels in normo-ovulatory women"
3845:
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134:
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3337:
2862:
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1324:
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3507:
2747:
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2380:
1877:"The anti-Müllerian hormone type II receptor: insights into the binding domains recognized by a monoclonal antibody and the natural ligand"
1657:"The anti-Müllerian hormone type II receptor: insights into the binding domains recognized by a monoclonal antibody and the natural ligand"
1482:"The anti-Müllerian hormone type II receptor: insights into the binding domains recognized by a monoclonal antibody and the natural ligand"
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1204:
Müllerian inhibiting substance type II receptor (MISIIR), also known as the Anti-Müllerian
Hormone Receptor, is expressed by
197:
172:
5116:
1778:"Müllerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications"
1289:
37:
4143:
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3631:
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114:
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have been developed that specifically target MISIIR and may be useful as vehicles for drugs and toxins for targeted
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4320:
4315:
4305:
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3471:
2964:
2357:
2140:
1135:
5111:
2025:"A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity"
2023:
Kevenaar ME, Themmen AP, Rivadeneira F, Uitterlinden AG, Laven JS, van Schoor NM, et al. (September 2007).
1990:"A polymorphism in the AMH type II receptor gene is associated with age at menopause in interaction with parity"
1988:
Kevenaar ME, Themmen AP, Rivadeneira F, Uitterlinden AG, Laven JS, van Schoor NM, et al. (September 2007).
1175:
interactions do not contribute significantly to the observed ligand specificity for AMH like the finger 1 loop.
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2192:
1377:"Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family"
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101:
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3013:
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1953:
Kevenaar ME, Themmen AP, Laven JS, Sonntag B, Fong SL, Uitterlinden AG, et al. (June 2007).
1918:
Kevenaar ME, Themmen AP, Laven JS, Sonntag B, Fong SL, Uitterlinden AG, et al. (June 2007).
1596:
1462:
1171:
146:
1559:"Isolation of anti-MISIIR scFv molecules from a phage display library by cell sorter biopanning"
1047:
1026:
988:
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1375:
Hart KN, Stocker WA, Nagykery NG, Walton KL, Harrison CA, Donahoe PK, et al. (June 2021).
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2011:
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Salhi I, Cambon-Roques S, Lamarre I, Laune D, Molina F, Pugnière M, et al. (May 2004).
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Salhi I, Cambon-Roques S, Lamarre I, Laune D, Molina F, Pugnière M, et al. (May 2004).
1627:
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Salhi I, Cambon-Roques S, Lamarre I, Laune D, Molina F, Pugnière M, et al. (May 2004).
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1706:"AMH and AMHR2 mutations: A spectrum of reproductive phenotypes across vertebrate species"
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Yuan QA, Simmons HH, Robinson MK, Russeva M, Marasco WA, Adams GP (August 2006).
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National Center for
Biotechnology Information, U.S. National Library of Medicine
1311:
National Center for
Biotechnology Information, U.S. National Library of Medicine
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1381:
Proceedings of the
National Academy of Sciences of the United States of America
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circulating AMH continues on after testis development and is secreted from the
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transmembrane receptor protein serine/threonine kinase signaling pathway
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2410:
1220:
in response to exposure to the Müllerian inhibiting substance (MIS).
1083:
811:
1557:
Yuan QA, Robinson MK, Simmons HH, Russeva M, Adams GP (March 2008).
1130:
also known as Müllerian
Inhibiting Substance Type II Receptor, is a
105:, AMHR, MISR2, MISRII, MRII, anti-Mullerian hormone receptor type 2
5173:
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3577:
3572:
3521:
3516:
3442:
3437:
3432:
3398:
3390:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
3192:
3177:
3172:
3167:
3162:
3157:
2645:
2477:
2405:
2350:
2345:
2340:
2219:
2212:
2207:
2202:
1157:
1704:
Mullen RD, Ontiveros AE, Moses MM, Behringer RR (November 2019).
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2325:
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2310:
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2300:
2197:
1184:
1147:
118:
4942:
4866:
4242:
3133:
3086:
2681:
2109:
725:
negative regulation of anti-Mullerian hormone signaling pathway
623:
transmembrane receptor protein serine/threonine kinase activity
4677:
3212:
3197:
20:
1840:
Wang HQ, Takakura K, Takebayashi K, Noda Y (December 2002).
643:
transforming growth factor beta-activated receptor activity
4938:
745:
transforming growth factor beta receptor signaling pathway
603:
transforming growth factor beta receptor activity, type II
374:
1170:
type II receptor family and adopts the characteristic
5229:
1776:
Teixeira J, Maheswaran S, Donahoe PK (October 2001).
1343:"Entrez Gene: Anti-Mullerian hormone receptor type 2"
539:
5125:
5089:
5058:
5027:
4976:
4880:
4778:
4761:
4744:
4727:
4698:
4558:
4458:
4399:
4290:
4256:
4196:
4172:
4133:
4099:
3805:
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3752:
3733:
3654:
3630:
3591:
3547:
3530:
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3470:
3451:
3417:
3388:
3321:
3287:
3147:
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2999:
2908:
2875:
2821:
2771:
2733:
2724:
2715:
2659:
2636:
2573:
2506:
2486:
2448:
2393:
2370:
2228:
2156:
2147:
1243:, and these males often have undescended testes or
1040:
1011:
981:
952:
1285:
1283:
1281:
1264:
1262:
1260:
321:
220:
40:for grammar, style, cohesion, tone, or spelling
1290:GRCm38: Ensembl release 89: ENSMUSG00000023047
4954:
3149:Non-specific serine/threonine protein kinases
3098:
2693:
2121:
1432:
1430:
1216:and these cancer cells have been reported to
8:
1360:
1358:
1269:GRCh38: Ensembl release 89: ENSG00000135409
1162:Annotated 3D structure of AMHR2, based on
4961:
4947:
4939:
4877:
4863:
4253:
4239:
3532:Goodpasture-antigen-binding protein kinase
3144:
3130:
3105:
3091:
3083:
2730:
2721:
2700:
2686:
2678:
2390:
2153:
2128:
2114:
2106:
1754:United States National Library of Medicine
785:
565:
362:
261:
158:
4245:Serine/threonine-specific protein kinases
3419:(isocitrate dehydrogenase (NADP+)) kinase
3136:Serine/threonine-specific protein kinases
3118:Serine/threonine-specific protein kinases
2098:at the U.S. National Library of Medicine
2040:
2005:
1970:
1935:
1900:
1857:
1793:
1729:
1680:
1631:
1582:
1505:
1410:
1400:
64:Learn how and when to remove this message
4780:Receptor protein serine/threonine kinase
1752:This article incorporates text from the
755:anti-Mullerian hormone signaling pathway
638:anti-Mullerian hormone receptor activity
618:protein serine/threonine kinase activity
5236:
4763:Low-density-lipoprotein receptor kinase
1256:
1146:in humans that is encoded by the AMHR2
1140:anti-Müllerian hormone receptor type 2
75:
3508:Fas-activated serine/threonine kinase
679:integral component of plasma membrane
326:
287:
282:
225:
184:
179:
7:
4789:Bone morphogenetic protein receptors
1451:10.1146/annurev-animal-020518-114955
3323:Dephospho-(reductase kinase) kinase
1439:Annual Review of Animal Biosciences
16:Receptor for anti-Müllerian hormone
3778:G-protein coupled receptor kinases
1811:Picard JY, Belville C (2002). "".
1037:
1008:
978:
949:
925:
906:
880:
861:
835:
816:
544:
462:
400:
379:
14:
3768:Beta adrenergic receptor kinase-2
3453:(tyrosine 3-monooxygenase) kinase
1813:Journal de la Société de Biologie
5239:
4460:Mitogen-activated protein kinase
1563:Cancer Immunology, Immunotherapy
1128:Anti-Müllerian hormone receptor,
310:
303:
297:
274:
209:
202:
196:
171:
25:
4846:Anti-Müllerian hormone receptor
4729:(acetyl-CoA carboxylase) kinase
4401:(RNA-polymerase)-subunit kinase
3763:Beta adrenergic receptor kinase
3754:Beta adrenergic receptor kinase
2950:Calcitonin gene-related peptide
2149:TGF beta superfamily of ligands
2096:Anti-Mullerian+hormone+receptor
4469:Extracellular signal-regulated
2296:Growth differentiation factors
669:integral component of membrane
528:More reference expression data
1:
4533:P38 mitogen-activated protein
3632:cGMP-dependent protein kinase
3593:cAMP-dependent protein kinase
3289:Pyruvate dehydrogenase kinase
3235:Ataxia telangiectasia mutated
1859:10.1016/s0015-0282(02)04351-0
1633:10.1158/1535-7163.MCT-06-0115
1620:Molecular Cancer Therapeutics
760:pattern specification process
295:
194:
5262:Genes on human chromosome 12
3332:AMP-activated protein kinase
2909:Other neuropeptide receptors
506:epithelium of female urethra
4247:(EC 2.7.11.21-EC 2.7.11.30)
2239:Bone morphogenetic proteins
2073:10.1016/j.ygyno.2007.09.010
1722:10.1016/j.ydbio.2019.07.006
5283:
4174:Elongation factor 2 kinase
3138:(EC 2.7.11.1-EC 2.7.11.20)
2717:G protein-coupled receptor
1825:10.1051/jbio/2002196030217
1192:. It is also expressed in
1076:Chr 15: 102.35 – 102.36 Mb
5117:Michaelis–Menten kinetics
4876:
4862:
4569:MAP kinase kinase kinases
4252:
4238:
4101:Myosin light-chain kinase
3807:Ca2+/calmodulin-dependent
3472:Myosin-heavy-chain kinase
3143:
3129:
3032:Atrial natriuretic factor
2829:Atrial natriuretic factor
1575:10.1007/s00262-007-0376-2
1325:"Mouse PubMed Reference:"
1307:"Human PubMed Reference:"
1114:
1109:
1105:
1098:
1082:
1063:
1044:
1015:
1004:
985:
956:
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932:
928:
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909:
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883:
868:
864:
855:
842:
838:
823:
819:
810:
795:
788:
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768:
730:Mullerian duct regression
568:
564:
552:
547:
538:
525:
474:
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403:
373:
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344:
331:
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112:
109:
99:
92:
87:
83:
78:
5009:Diffusion-limited enzyme
4869:Dual-specificity kinases
3001:Type I cytokine receptor
2456:Activin type 2 receptors
2401:Activin type 1 receptors
2100:Medical Subject Headings
1532:Clinical Cancer Research
1069:Chr 12: 53.42 – 53.43 Mb
720:female gonad development
514:lamina propria of vagina
4292:Cyclin-dependent kinase
1881:The Biochemical Journal
1846:Fertility and Sterility
1661:The Biochemical Journal
1486:The Biochemical Journal
1402:10.1073/pnas.2104809118
735:protein phosphorylation
593:protein kinase activity
494:muscle layer of urethra
3024:Enzyme-linked receptor
2709:Neuropeptide receptors
2358:Anti-müllerian hormone
2141:TGFβ signaling pathway
1795:10.1210/edrv.22.5.0445
1163:
1136:anti-Müllerian hormone
705:male gonad development
448:skeletal muscle tissue
328:15 F3|15 57.58 cM
5102:Eadie–Hofstee diagram
5035:Allosteric regulation
2042:10.1093/humrep/dem176
2007:10.1093/humrep/dem176
1972:10.1093/humrep/dem036
1937:10.1093/humrep/dem036
1710:Developmental Biology
1200:Clinical significance
1161:
750:BMP signaling pathway
648:growth factor binding
502:epithelium of urethra
289:Chromosome 15 (mouse)
187:Chromosome 12 (human)
5112:Lineweaver–Burk plot
4135:Phosphorylase kinase
2061:Gynecologic Oncology
1138:(AMH). Furthermore,
583:transferase activity
486:facial motor nucleus
416:right adrenal cortex
2193:Activin and inhibin
1393:2021PNAS..11804809H
1387:(26): e2104809118.
715:sex differentiation
478:seminiferous tubule
424:left adrenal cortex
5071:Enzyme superfamily
5004:Enzyme promiscuity
4746:Tropomyosin kinase
4700:Tau-protein kinase
2372:TGF beta receptors
2029:Human Reproduction
1994:Human Reproduction
1959:Human Reproduction
1924:Human Reproduction
1893:10.1042/BJ20031961
1756:, which is in the
1673:10.1042/BJ20031961
1498:10.1042/bj20031961
1172:three-finger toxin
1164:
890:ENSMUSG00000023047
698:Biological process
662:Cellular component
588:nucleotide binding
576:Molecular function
420:left adrenal gland
44:You can assist by
5227:
5226:
4936:
4935:
4932:
4931:
4928:
4927:
4858:
4857:
4854:
4853:
4234:
4233:
4230:
4229:
3715:Protein kinase N1
3670:Protein kinase Cζ
3080:
3079:
2995:
2994:
2960:GPCR neuropeptide
2871:
2870:
2726:Hormone receptors
2675:
2674:
2575:Ligand inhibitors
2502:
2501:
2366:
2365:
1887:(Pt 3): 785–793.
1782:Endocrine Reviews
1667:(Pt 3): 785–793.
1538:(11): 3488–3499.
1492:(Pt 3): 785–793.
1166:AMHR2 belongs to
1125:
1124:
1121:
1120:
1094:
1093:
1059:
1058:
1034:
1033:
1000:
999:
975:
974:
941:
940:
922:
921:
896:
895:
877:
876:
851:
850:
832:
831:
780:
779:
608:metal ion binding
560:
559:
556:
555:
534:
533:
521:
520:
459:
458:
357:
356:
256:
255:
151:AMHR2 - orthologs
74:
73:
66:
5274:
5244:
5243:
5235:
5107:Hanes–Woolf plot
5050:Enzyme activator
5045:Enzyme inhibitor
5019:Enzyme catalysis
4963:
4956:
4949:
4940:
4878:
4864:
4511:C-Jun N-terminal
4254:
4240:
3744:Rhodopsin kinase
3735:Rhodopsin kinase
3665:Protein kinase C
3656:Protein kinase C
3641:Protein kinase G
3602:Protein kinase A
3213:Protein kinase B
3145:
3131:
3107:
3100:
3093:
3084:
2877:Opioid receptors
2731:
2722:
2702:
2695:
2688:
2679:
2391:
2154:
2130:
2123:
2116:
2107:
2084:
2054:
2044:
2035:(9): 2382–2388.
2019:
2009:
2000:(9): 2382–2388.
1984:
1974:
1965:(6): 1547–1554.
1949:
1939:
1930:(6): 1547–1554.
1914:
1904:
1871:
1861:
1852:(6): 1329–1330.
1836:
1807:
1797:
1744:
1743:
1733:
1701:
1695:
1694:
1684:
1652:
1646:
1645:
1635:
1626:(8): 2096–2105.
1611:
1605:
1604:
1586:
1554:
1548:
1547:
1526:
1520:
1519:
1509:
1477:
1471:
1470:
1434:
1425:
1424:
1414:
1404:
1372:
1362:
1353:
1352:
1350:
1349:
1339:
1333:
1332:
1321:
1315:
1314:
1303:
1297:
1287:
1276:
1266:
1214:prostate cancers
1107:
1106:
1078:
1071:
1054:
1038:
1029:
1009:
1005:RefSeq (protein)
995:
979:
970:
950:
926:
907:
881:
862:
836:
817:
786:
689:receptor complex
566:
545:
530:
470:
468:Top expressed in
463:
440:body of pancreas
408:
406:Top expressed in
401:
380:
363:
353:
340:
329:
314:
307:
301:
290:
278:
262:
252:
239:
228:
213:
206:
200:
189:
175:
159:
153:
104:
97:
76:
69:
62:
58:
55:
49:
29:
28:
21:
5282:
5281:
5277:
5276:
5275:
5273:
5272:
5271:
5252:
5251:
5250:
5238:
5230:
5228:
5223:
5135:Oxidoreductases
5121:
5097:Enzyme kinetics
5085:
5081:List of enzymes
5054:
5023:
4994:Catalytic triad
4972:
4967:
4937:
4924:
4872:
4850:
4774:
4757:
4740:
4723:
4694:
4554:
4454:
4425:P70-S6 Kinase 1
4395:
4286:
4248:
4226:
4192:
4168:
4129:
4095:
3801:
3772:
3748:
3729:
3650:
3626:
3587:
3543:
3526:
3502:
3496:Aurora C kinase
3491:Aurora B kinase
3486:Aurora A kinase
3466:
3447:
3413:
3384:
3317:
3283:
3139:
3125:
3111:
3081:
3076:
3048:
3018:
2991:
2904:
2867:
2846:Cholecystokinin
2817:
2767:
2711:
2706:
2676:
2671:
2655:
2632:
2569:
2498:
2482:
2444:
2374:
2362:
2224:
2171:TGF beta family
2143:
2134:
2092:
2087:
2057:
2022:
1987:
1952:
1917:
1874:
1839:
1810:
1775:
1771:
1769:Further reading
1765:
1748:
1747:
1703:
1702:
1698:
1654:
1653:
1649:
1613:
1612:
1608:
1556:
1555:
1551:
1528:
1527:
1523:
1479:
1478:
1474:
1436:
1435:
1428:
1374:
1364:
1363:
1356:
1347:
1345:
1341:
1340:
1336:
1323:
1322:
1318:
1305:
1304:
1300:
1288:
1279:
1267:
1258:
1253:
1202:
1181:
1156:
1116:View/Edit Mouse
1111:View/Edit Human
1074:
1067:
1064:Location (UCSC)
1050:
1046:
1025:
1021:
1017:
991:
987:
966:
962:
958:
871:ENSG00000135409
764:
710:phosphorylation
693:
684:plasma membrane
657:
628:protein binding
613:kinase activity
598:hormone binding
526:
517:
512:
508:
504:
500:
496:
492:
488:
484:
480:
466:
455:
450:
446:
442:
438:
434:
430:
426:
422:
418:
404:
348:
335:
327:
317:
316:
315:
308:
288:
265:Gene location (
247:
234:
226:
216:
215:
214:
207:
185:
162:Gene location (
113:
100:
93:
70:
59:
53:
50:
43:
30:
26:
17:
12:
11:
5:
5280:
5278:
5270:
5269:
5264:
5254:
5253:
5249:
5248:
5225:
5224:
5222:
5221:
5208:
5195:
5182:
5169:
5156:
5143:
5129:
5127:
5123:
5122:
5120:
5119:
5114:
5109:
5104:
5099:
5093:
5091:
5087:
5086:
5084:
5083:
5078:
5073:
5068:
5062:
5060:
5059:Classification
5056:
5055:
5053:
5052:
5047:
5042:
5037:
5031:
5029:
5025:
5024:
5022:
5021:
5016:
5011:
5006:
5001:
4996:
4991:
4986:
4980:
4978:
4974:
4973:
4968:
4966:
4965:
4958:
4951:
4943:
4934:
4933:
4930:
4929:
4926:
4925:
4923:
4922:
4917:
4912:
4907:
4902:
4897:
4892:
4886:
4884:
4874:
4873:
4867:
4860:
4859:
4856:
4855:
4852:
4851:
4849:
4848:
4843:
4838:
4833:
4828:
4823:
4818:
4813:
4812:
4811:
4806:
4801:
4796:
4785:
4783:
4782:(EC 2.7.11.30)
4776:
4775:
4773:
4772:
4768:
4766:
4765:(EC 2.7.11.29)
4759:
4758:
4756:
4755:
4751:
4749:
4748:(EC 2.7.11.28)
4742:
4741:
4739:
4738:
4734:
4732:
4731:(EC 2.7.11.27)
4725:
4724:
4722:
4721:
4716:
4711:
4705:
4703:
4702:(EC 2.7.11.26)
4696:
4695:
4693:
4692:
4687:
4682:
4681:
4680:
4675:
4670:
4665:
4660:
4655:
4650:
4640:
4639:
4638:
4633:
4628:
4623:
4613:
4612:
4611:
4606:
4601:
4596:
4591:
4586:
4581:
4576:
4565:
4563:
4562:(EC 2.7.11.25)
4556:
4555:
4553:
4552:
4551:
4550:
4545:
4540:
4530:
4529:
4528:
4523:
4518:
4508:
4507:
4506:
4501:
4496:
4491:
4486:
4481:
4476:
4465:
4463:
4462:(EC 2.7.11.24)
4456:
4455:
4453:
4452:
4447:
4442:
4437:
4432:
4427:
4422:
4417:
4412:
4406:
4404:
4403:(EC 2.7.11.23)
4397:
4396:
4394:
4393:
4388:
4383:
4378:
4373:
4368:
4363:
4358:
4353:
4348:
4343:
4338:
4333:
4328:
4323:
4318:
4313:
4308:
4303:
4297:
4295:
4294:(EC 2.7.11.22)
4288:
4287:
4285:
4284:
4279:
4274:
4269:
4263:
4261:
4260:(EC 2.7.11.21)
4250:
4249:
4243:
4236:
4235:
4232:
4231:
4228:
4227:
4225:
4224:
4219:
4214:
4209:
4203:
4201:
4200:(EC 2.7.11.21)
4194:
4193:
4191:
4190:
4185:
4179:
4177:
4176:(EC 2.7.11.20)
4170:
4169:
4167:
4166:
4161:
4156:
4151:
4146:
4140:
4138:
4137:(EC 2.7.11.19)
4131:
4130:
4128:
4127:
4122:
4117:
4112:
4106:
4104:
4103:(EC 2.7.11.18)
4097:
4096:
4094:
4093:
4088:
4083:
4078:
4073:
4068:
4063:
4058:
4053:
4048:
4043:
4038:
4033:
4028:
4023:
4018:
4013:
4008:
4003:
3998:
3993:
3988:
3983:
3978:
3973:
3968:
3963:
3958:
3953:
3948:
3943:
3938:
3933:
3928:
3923:
3918:
3913:
3908:
3903:
3898:
3893:
3888:
3883:
3878:
3873:
3868:
3863:
3858:
3853:
3848:
3843:
3838:
3833:
3828:
3823:
3818:
3812:
3810:
3809:(EC 2.7.11.17)
3803:
3802:
3800:
3799:
3794:
3789:
3783:
3781:
3780:(EC 2.7.11.16)
3774:
3773:
3771:
3770:
3765:
3759:
3757:
3756:(EC 2.7.11.15)
3750:
3749:
3747:
3746:
3740:
3738:
3737:(EC 2.7.11.14)
3731:
3730:
3728:
3727:
3722:
3717:
3712:
3707:
3702:
3697:
3692:
3687:
3682:
3677:
3672:
3667:
3661:
3659:
3658:(EC 2.7.11.13)
3652:
3651:
3649:
3648:
3643:
3637:
3635:
3634:(EC 2.7.11.12)
3628:
3627:
3625:
3624:
3619:
3614:
3609:
3604:
3598:
3596:
3595:(EC 2.7.11.11)
3589:
3588:
3586:
3585:
3580:
3575:
3570:
3565:
3560:
3554:
3552:
3551:(EC 2.7.11.10)
3545:
3544:
3542:
3541:
3537:
3535:
3528:
3527:
3525:
3524:
3519:
3513:
3511:
3504:
3503:
3501:
3500:
3499:
3498:
3493:
3488:
3477:
3475:
3468:
3467:
3465:
3464:
3458:
3456:
3449:
3448:
3446:
3445:
3440:
3435:
3430:
3424:
3422:
3415:
3414:
3412:
3411:
3406:
3401:
3395:
3393:
3386:
3385:
3383:
3382:
3381:
3380:
3375:
3370:
3362:
3361:
3360:
3355:
3347:
3346:
3345:
3340:
3328:
3326:
3319:
3318:
3316:
3315:
3310:
3305:
3300:
3294:
3292:
3285:
3284:
3282:
3281:
3280:
3279:
3269:
3268:
3267:
3262:
3257:
3252:
3242:
3237:
3232:
3231:
3230:
3225:
3220:
3210:
3205:
3200:
3195:
3190:
3185:
3180:
3175:
3170:
3165:
3160:
3154:
3152:
3141:
3140:
3134:
3127:
3126:
3112:
3110:
3109:
3102:
3095:
3087:
3078:
3077:
3075:
3074:
3073:
3072:
3067:
3056:
3054:
3050:
3049:
3047:
3046:
3045:
3044:
3039:
3028:
3026:
3020:
3019:
3017:
3016:
3011:
3005:
3003:
2997:
2996:
2993:
2992:
2990:
2989:
2984:
2983:
2982:
2977:
2972:
2967:
2957:
2952:
2947:
2946:
2945:
2935:
2934:
2933:
2928:
2918:
2912:
2910:
2906:
2905:
2903:
2902:
2897:
2892:
2887:
2881:
2879:
2873:
2872:
2869:
2868:
2866:
2865:
2860:
2859:
2858:
2853:
2843:
2838:
2837:
2836:
2825:
2823:
2819:
2818:
2816:
2815:
2810:
2805:
2800:
2799:
2798:
2793:
2788:
2777:
2775:
2769:
2768:
2766:
2765:
2760:
2755:
2750:
2745:
2739:
2737:
2728:
2719:
2713:
2712:
2707:
2705:
2704:
2697:
2690:
2682:
2673:
2672:
2670:
2669:
2663:
2661:
2657:
2656:
2654:
2653:
2648:
2642:
2640:
2634:
2633:
2631:
2630:
2625:
2620:
2615:
2610:
2605:
2600:
2595:
2590:
2585:
2579:
2577:
2571:
2570:
2568:
2567:
2562:
2556:
2547:
2541:
2536:
2531:
2526:
2516:
2514:
2504:
2503:
2500:
2499:
2497:
2496:
2490:
2488:
2484:
2483:
2481:
2480:
2475:
2470:
2469:
2468:
2463:
2452:
2450:
2446:
2445:
2443:
2442:
2441:
2440:
2435:
2425:
2420:
2419:
2418:
2413:
2408:
2397:
2395:
2388:
2368:
2367:
2364:
2363:
2361:
2360:
2355:
2354:
2353:
2348:
2343:
2338:
2333:
2331:Myostatin/GDF8
2328:
2323:
2318:
2313:
2308:
2303:
2293:
2292:
2291:
2286:
2281:
2276:
2271:
2266:
2261:
2256:
2251:
2246:
2235:
2233:
2226:
2225:
2223:
2222:
2217:
2216:
2215:
2210:
2205:
2200:
2190:
2189:
2188:
2183:
2178:
2167:
2165:
2151:
2145:
2144:
2137:Cell signaling
2135:
2133:
2132:
2125:
2118:
2110:
2104:
2103:
2091:
2090:External links
2088:
2086:
2085:
2067:(1): 141–148.
2055:
2020:
1985:
1950:
1915:
1872:
1837:
1819:(3): 217–221.
1808:
1788:(5): 657–674.
1772:
1770:
1767:
1763:
1762:
1746:
1745:
1696:
1647:
1606:
1569:(3): 367–378.
1549:
1521:
1472:
1426:
1354:
1334:
1316:
1298:
1277:
1255:
1254:
1252:
1249:
1245:cryptorchidism
1229:cancer therapy
1201:
1198:
1180:
1177:
1155:
1152:
1123:
1122:
1119:
1118:
1113:
1103:
1102:
1096:
1095:
1092:
1091:
1089:
1087:
1080:
1079:
1072:
1065:
1061:
1060:
1057:
1056:
1042:
1041:
1035:
1032:
1031:
1013:
1012:
1006:
1002:
1001:
998:
997:
983:
982:
976:
973:
972:
954:
953:
947:
943:
942:
939:
938:
930:
929:
923:
920:
919:
911:
910:
904:
898:
897:
894:
893:
885:
884:
878:
875:
874:
866:
865:
859:
853:
852:
849:
848:
840:
839:
833:
830:
829:
821:
820:
814:
808:
807:
802:
797:
793:
792:
782:
781:
778:
777:
766:
765:
763:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
701:
699:
695:
694:
692:
691:
686:
681:
676:
671:
665:
663:
659:
658:
656:
655:
650:
645:
640:
635:
630:
625:
620:
615:
610:
605:
600:
595:
590:
585:
579:
577:
573:
572:
562:
561:
558:
557:
554:
553:
550:
549:
542:
536:
535:
532:
531:
523:
522:
519:
518:
516:
515:
511:
507:
503:
499:
495:
491:
487:
483:
479:
475:
472:
471:
460:
457:
456:
454:
453:
449:
445:
441:
437:
433:
429:
425:
421:
417:
413:
410:
409:
397:
396:
388:
377:
371:
370:
367:RNA expression
359:
358:
355:
354:
346:
342:
341:
333:
330:
325:
319:
318:
309:
302:
296:
292:
291:
286:
280:
279:
271:
270:
258:
257:
254:
253:
245:
241:
240:
232:
229:
224:
218:
217:
208:
201:
195:
191:
190:
183:
177:
176:
168:
167:
155:
154:
111:
107:
106:
98:
90:
89:
85:
84:
81:
80:
72:
71:
33:
31:
24:
15:
13:
10:
9:
6:
4:
3:
2:
5279:
5268:
5265:
5263:
5260:
5259:
5257:
5247:
5242:
5237:
5233:
5219:
5215:
5214:
5209:
5206:
5202:
5201:
5196:
5193:
5189:
5188:
5183:
5180:
5176:
5175:
5170:
5167:
5163:
5162:
5157:
5154:
5150:
5149:
5144:
5141:
5137:
5136:
5131:
5130:
5128:
5124:
5118:
5115:
5113:
5110:
5108:
5105:
5103:
5100:
5098:
5095:
5094:
5092:
5088:
5082:
5079:
5077:
5076:Enzyme family
5074:
5072:
5069:
5067:
5064:
5063:
5061:
5057:
5051:
5048:
5046:
5043:
5041:
5040:Cooperativity
5038:
5036:
5033:
5032:
5030:
5026:
5020:
5017:
5015:
5012:
5010:
5007:
5005:
5002:
5000:
4999:Oxyanion hole
4997:
4995:
4992:
4990:
4987:
4985:
4982:
4981:
4979:
4975:
4971:
4964:
4959:
4957:
4952:
4950:
4945:
4944:
4941:
4921:
4918:
4916:
4913:
4911:
4908:
4906:
4903:
4901:
4898:
4896:
4893:
4891:
4888:
4887:
4885:
4883:
4879:
4875:
4870:
4865:
4861:
4847:
4844:
4842:
4839:
4837:
4834:
4832:
4829:
4827:
4824:
4822:
4819:
4817:
4814:
4810:
4807:
4805:
4802:
4800:
4797:
4795:
4792:
4791:
4790:
4787:
4786:
4784:
4781:
4777:
4770:
4769:
4767:
4764:
4760:
4753:
4752:
4750:
4747:
4743:
4736:
4735:
4733:
4730:
4726:
4720:
4717:
4715:
4712:
4710:
4707:
4706:
4704:
4701:
4697:
4691:
4688:
4686:
4683:
4679:
4676:
4674:
4671:
4669:
4666:
4664:
4661:
4659:
4656:
4654:
4651:
4649:
4646:
4645:
4644:
4641:
4637:
4634:
4632:
4629:
4627:
4624:
4622:
4619:
4618:
4617:
4614:
4610:
4607:
4605:
4602:
4600:
4597:
4595:
4592:
4590:
4587:
4585:
4582:
4580:
4577:
4575:
4572:
4571:
4570:
4567:
4566:
4564:
4561:
4557:
4549:
4546:
4544:
4541:
4539:
4536:
4535:
4534:
4531:
4527:
4524:
4522:
4519:
4517:
4514:
4513:
4512:
4509:
4505:
4502:
4500:
4497:
4495:
4492:
4490:
4487:
4485:
4482:
4480:
4477:
4475:
4472:
4471:
4470:
4467:
4466:
4464:
4461:
4457:
4451:
4448:
4446:
4443:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4407:
4405:
4402:
4398:
4392:
4389:
4387:
4384:
4382:
4379:
4377:
4374:
4372:
4369:
4367:
4364:
4362:
4359:
4357:
4354:
4352:
4349:
4347:
4344:
4342:
4339:
4337:
4334:
4332:
4329:
4327:
4324:
4322:
4319:
4317:
4314:
4312:
4309:
4307:
4304:
4302:
4299:
4298:
4296:
4293:
4289:
4283:
4280:
4278:
4275:
4273:
4270:
4268:
4265:
4264:
4262:
4259:
4255:
4251:
4246:
4241:
4237:
4223:
4220:
4218:
4215:
4213:
4210:
4208:
4205:
4204:
4202:
4199:
4195:
4189:
4186:
4184:
4181:
4180:
4178:
4175:
4171:
4165:
4162:
4160:
4157:
4155:
4152:
4150:
4147:
4145:
4142:
4141:
4139:
4136:
4132:
4126:
4123:
4121:
4118:
4116:
4113:
4111:
4108:
4107:
4105:
4102:
4098:
4092:
4089:
4087:
4084:
4082:
4079:
4077:
4074:
4072:
4069:
4067:
4064:
4062:
4059:
4057:
4054:
4052:
4049:
4047:
4044:
4042:
4039:
4037:
4034:
4032:
4029:
4027:
4024:
4022:
4019:
4017:
4014:
4012:
4009:
4007:
4004:
4002:
3999:
3997:
3994:
3992:
3989:
3987:
3984:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3952:
3949:
3947:
3944:
3942:
3939:
3937:
3934:
3932:
3929:
3927:
3924:
3922:
3919:
3917:
3914:
3912:
3909:
3907:
3904:
3902:
3899:
3897:
3894:
3892:
3889:
3887:
3884:
3882:
3879:
3877:
3874:
3872:
3869:
3867:
3864:
3862:
3859:
3857:
3854:
3852:
3849:
3847:
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3827:
3824:
3822:
3819:
3817:
3814:
3813:
3811:
3808:
3804:
3798:
3795:
3793:
3790:
3788:
3785:
3784:
3782:
3779:
3775:
3769:
3766:
3764:
3761:
3760:
3758:
3755:
3751:
3745:
3742:
3741:
3739:
3736:
3732:
3726:
3723:
3721:
3718:
3716:
3713:
3711:
3708:
3706:
3703:
3701:
3698:
3696:
3693:
3691:
3688:
3686:
3683:
3681:
3678:
3676:
3673:
3671:
3668:
3666:
3663:
3662:
3660:
3657:
3653:
3647:
3644:
3642:
3639:
3638:
3636:
3633:
3629:
3623:
3620:
3618:
3615:
3613:
3610:
3608:
3605:
3603:
3600:
3599:
3597:
3594:
3590:
3584:
3581:
3579:
3576:
3574:
3571:
3569:
3566:
3564:
3561:
3559:
3556:
3555:
3553:
3550:
3546:
3539:
3538:
3536:
3534:(EC 2.7.11.9)
3533:
3529:
3523:
3520:
3518:
3515:
3514:
3512:
3510:(EC 2.7.11.8)
3509:
3505:
3497:
3494:
3492:
3489:
3487:
3484:
3483:
3482:
3481:Aurora kinase
3479:
3478:
3476:
3474:(EC 2.7.11.7)
3473:
3469:
3463:
3460:
3459:
3457:
3455:(EC 2.7.11.6)
3454:
3450:
3444:
3441:
3439:
3436:
3434:
3431:
3429:
3426:
3425:
3423:
3421:(EC 2.7.11.5)
3420:
3416:
3410:
3407:
3405:
3402:
3400:
3397:
3396:
3394:
3392:(EC 2.7.11.4)
3391:
3387:
3379:
3376:
3374:
3371:
3369:
3366:
3365:
3363:
3359:
3356:
3354:
3351:
3350:
3348:
3344:
3341:
3339:
3336:
3335:
3333:
3330:
3329:
3327:
3325:(EC 2.7.11.3)
3324:
3320:
3314:
3311:
3309:
3306:
3304:
3301:
3299:
3296:
3295:
3293:
3291:(EC 2.7.11.2)
3290:
3286:
3278:
3275:
3274:
3273:
3270:
3266:
3263:
3261:
3258:
3256:
3253:
3251:
3248:
3247:
3246:
3245:EIF-2 kinases
3243:
3241:
3238:
3236:
3233:
3229:
3226:
3224:
3221:
3219:
3216:
3215:
3214:
3211:
3209:
3206:
3204:
3201:
3199:
3196:
3194:
3191:
3189:
3186:
3184:
3181:
3179:
3176:
3174:
3171:
3169:
3166:
3164:
3161:
3159:
3156:
3155:
3153:
3151:(EC 2.7.11.1)
3150:
3146:
3142:
3137:
3132:
3128:
3123:
3119:
3115:
3108:
3103:
3101:
3096:
3094:
3089:
3088:
3085:
3071:
3068:
3066:
3063:
3062:
3061:
3058:
3057:
3055:
3051:
3043:
3040:
3038:
3035:
3034:
3033:
3030:
3029:
3027:
3025:
3021:
3015:
3012:
3010:
3007:
3006:
3004:
3002:
2998:
2988:
2985:
2981:
2978:
2976:
2973:
2971:
2968:
2966:
2963:
2962:
2961:
2958:
2956:
2953:
2951:
2948:
2944:
2941:
2940:
2939:
2936:
2932:
2929:
2927:
2924:
2923:
2922:
2919:
2917:
2914:
2913:
2911:
2907:
2901:
2898:
2896:
2893:
2891:
2888:
2886:
2883:
2882:
2880:
2878:
2874:
2864:
2861:
2857:
2854:
2852:
2849:
2848:
2847:
2844:
2842:
2839:
2835:
2832:
2831:
2830:
2827:
2826:
2824:
2820:
2814:
2811:
2809:
2806:
2804:
2801:
2797:
2794:
2792:
2789:
2787:
2784:
2783:
2782:
2779:
2778:
2776:
2774:
2770:
2764:
2761:
2759:
2756:
2754:
2751:
2749:
2746:
2744:
2741:
2740:
2738:
2736:
2732:
2729:
2727:
2723:
2720:
2718:
2714:
2710:
2703:
2698:
2696:
2691:
2689:
2684:
2683:
2680:
2668:
2665:
2664:
2662:
2658:
2652:
2649:
2647:
2644:
2643:
2641:
2639:
2635:
2629:
2626:
2624:
2621:
2619:
2616:
2614:
2611:
2609:
2606:
2604:
2601:
2599:
2596:
2594:
2591:
2589:
2586:
2584:
2581:
2580:
2578:
2576:
2572:
2566:
2563:
2560:
2557:
2555:
2551:
2548:
2545:
2542:
2540:
2537:
2535:
2532:
2530:
2527:
2525:
2521:
2518:
2517:
2515:
2513:
2509:
2505:
2495:
2492:
2491:
2489:
2485:
2479:
2476:
2474:
2471:
2467:
2464:
2462:
2459:
2458:
2457:
2454:
2453:
2451:
2447:
2439:
2436:
2434:
2431:
2430:
2429:
2426:
2424:
2421:
2417:
2414:
2412:
2409:
2407:
2404:
2403:
2402:
2399:
2398:
2396:
2392:
2389:
2386:
2382:
2378:
2373:
2369:
2359:
2356:
2352:
2349:
2347:
2344:
2342:
2339:
2337:
2334:
2332:
2329:
2327:
2324:
2322:
2319:
2317:
2314:
2312:
2309:
2307:
2304:
2302:
2299:
2298:
2297:
2294:
2290:
2287:
2285:
2282:
2280:
2277:
2275:
2272:
2270:
2267:
2265:
2262:
2260:
2257:
2255:
2252:
2250:
2247:
2245:
2242:
2241:
2240:
2237:
2236:
2234:
2232:
2227:
2221:
2218:
2214:
2211:
2209:
2206:
2204:
2201:
2199:
2196:
2195:
2194:
2191:
2187:
2184:
2182:
2179:
2177:
2174:
2173:
2172:
2169:
2168:
2166:
2164:
2160:
2155:
2152:
2150:
2146:
2142:
2138:
2131:
2126:
2124:
2119:
2117:
2112:
2111:
2108:
2101:
2097:
2094:
2093:
2089:
2082:
2078:
2074:
2070:
2066:
2062:
2056:
2052:
2048:
2043:
2038:
2034:
2030:
2026:
2021:
2017:
2013:
2008:
2003:
1999:
1995:
1991:
1986:
1982:
1978:
1973:
1968:
1964:
1960:
1956:
1951:
1947:
1943:
1938:
1933:
1929:
1925:
1921:
1916:
1912:
1908:
1903:
1898:
1894:
1890:
1886:
1882:
1878:
1873:
1869:
1865:
1860:
1855:
1851:
1847:
1843:
1838:
1834:
1830:
1826:
1822:
1818:
1815:(in French).
1814:
1809:
1805:
1801:
1796:
1791:
1787:
1783:
1779:
1774:
1773:
1768:
1766:
1761:
1759:
1758:public domain
1755:
1750:
1749:
1741:
1737:
1732:
1727:
1723:
1719:
1715:
1711:
1707:
1700:
1697:
1692:
1688:
1683:
1678:
1674:
1670:
1666:
1662:
1658:
1651:
1648:
1643:
1639:
1634:
1629:
1625:
1621:
1617:
1610:
1607:
1602:
1598:
1594:
1590:
1585:
1580:
1576:
1572:
1568:
1564:
1560:
1553:
1550:
1545:
1541:
1537:
1533:
1525:
1522:
1517:
1513:
1508:
1503:
1499:
1495:
1491:
1487:
1483:
1476:
1473:
1468:
1464:
1460:
1456:
1452:
1448:
1444:
1440:
1433:
1431:
1427:
1422:
1418:
1413:
1408:
1403:
1398:
1394:
1390:
1386:
1382:
1378:
1371:
1367:
1361:
1359:
1355:
1344:
1338:
1335:
1330:
1326:
1320:
1317:
1312:
1308:
1302:
1299:
1295:
1291:
1286:
1284:
1282:
1278:
1274:
1270:
1265:
1263:
1261:
1257:
1250:
1248:
1246:
1242:
1238:
1232:
1230:
1226:
1221:
1219:
1215:
1211:
1207:
1199:
1197:
1195:
1191:
1190:Sertoli Cells
1186:
1178:
1176:
1173:
1169:
1160:
1153:
1151:
1149:
1145:
1141:
1137:
1133:
1129:
1117:
1112:
1108:
1104:
1101:
1097:
1090:
1088:
1085:
1081:
1077:
1073:
1070:
1066:
1062:
1055:
1053:
1049:
1043:
1039:
1036:
1030:
1028:
1024:
1020:
1014:
1010:
1007:
1003:
996:
994:
990:
984:
980:
977:
971:
969:
965:
961:
955:
951:
948:
946:RefSeq (mRNA)
944:
937:
936:
931:
927:
924:
918:
917:
912:
908:
905:
903:
899:
892:
891:
886:
882:
879:
873:
872:
867:
863:
860:
858:
854:
847:
846:
841:
837:
834:
828:
827:
822:
818:
815:
813:
809:
806:
803:
801:
798:
794:
791:
787:
783:
776:
772:
767:
761:
758:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
702:
700:
697:
696:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
666:
664:
661:
660:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
599:
596:
594:
591:
589:
586:
584:
581:
580:
578:
575:
574:
571:
570:Gene ontology
567:
563:
551:
546:
543:
541:
537:
529:
524:
513:
510:soleus muscle
509:
505:
501:
498:Gonadal ridge
497:
493:
489:
485:
481:
477:
476:
473:
469:
464:
461:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
414:
411:
407:
402:
399:
398:
395:
393:
389:
387:
386:
382:
381:
378:
376:
372:
368:
364:
360:
352:
347:
343:
339:
334:
324:
320:
313:
306:
300:
293:
285:
281:
277:
272:
268:
263:
259:
251:
246:
242:
238:
233:
223:
219:
212:
205:
199:
192:
188:
182:
178:
174:
169:
165:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
108:
103:
96:
91:
86:
82:
77:
68:
65:
57:
47:
41:
39:
34:This article
32:
23:
22:
19:
5213:Translocases
5210:
5197:
5184:
5171:
5158:
5148:Transferases
5145:
5132:
4989:Binding site
4845:
4420:P70S6 kinase
2763:Somatostatin
2735:Hypothalamic
2472:
2064:
2060:
2032:
2028:
1997:
1993:
1962:
1958:
1927:
1923:
1884:
1880:
1849:
1845:
1816:
1812:
1785:
1781:
1764:
1751:
1713:
1709:
1699:
1664:
1660:
1650:
1623:
1619:
1609:
1566:
1562:
1552:
1535:
1531:
1524:
1489:
1485:
1475:
1442:
1438:
1384:
1380:
1346:. Retrieved
1337:
1328:
1319:
1310:
1301:
1233:
1222:
1203:
1194:Leydig cells
1182:
1165:
1139:
1127:
1126:
1052:NP_001343504
1045:
1023:NP_001158163
1019:NP_001158162
1016:
993:NM_001356575
986:
964:NM_001164691
960:NM_001164690
957:
933:
914:
888:
869:
843:
824:
804:
799:
653:SMAD binding
482:spermatocyte
444:right testis
390:
383:
349:102,363,068
336:102,353,802
110:External IDs
60:
51:
38:copy editing
36:may require
35:
18:
4984:Active site
4871:(EC 2.7.12)
4258:Polo kinase
4198:Polo kinase
2987:Neurotensin
2916:Angiotensin
2781:Vasopressin
2638:Coreceptors
2598:Follistatin
2508:Transducers
1445:: 149–172.
1223:Monoclonal
633:ATP binding
436:left testis
432:right ovary
248:53,431,672
235:53,423,855
88:Identifiers
5256:Categories
5187:Isomerases
5161:Hydrolases
5028:Regulation
3549:IκB kinase
3124:2.7.11-12)
2938:Tachykinin
2921:Bradykinin
2900:Nociceptin
2841:Calcitonin
2494:betaglycan
2229:Ligand of
2157:Ligand of
1716:(1): 1–9.
1348:2018-06-07
1296:, May 2017
1275:, May 2017
1251:References
1225:Antibodies
428:left ovary
394:(ortholog)
131:HomoloGene
46:editing it
5267:EC 2.7.11
5066:EC number
3675:PKC alpha
3014:Prolactin
2773:Pituitary
1373:;
1241:missenses
1237:deletions
1154:Structure
1048:NP_653130
1027:NP_065434
989:NM_144547
968:NM_020547
790:Orthologs
139:GeneCards
54:July 2024
5090:Kinetics
5014:Cofactor
4977:Activity
4031:KIAA0999
3926:MAPKAPK5
3921:MAPKAPK3
3916:MAPKAPK2
2803:Oxytocin
2583:Cerberus
2081:17988723
2051:17636279
2016:17636279
1981:17337470
1946:17337470
1911:14750901
1868:12477536
1833:12462075
1804:11588147
1740:31301298
1691:14750901
1642:16928831
1601:13075446
1593:17676323
1584:11031043
1544:10589763
1516:14750901
1467:52954655
1459:30303691
1421:34155118
1292:–
1271:–
1218:apoptose
1179:Function
1134:for the
1132:receptor
1100:Wikidata
769:Sources:
674:membrane
227:12q13.13
5246:Biology
5200:Ligases
4970:Enzymes
4690:MAP3K14
4668:MAP3K11
4663:MAP3K10
4653:MAP3K13
4648:MAP3K12
4450:RPS6KC1
4445:RPS6KA1
4440:RPS6KA3
4435:RPS6KA2
4430:RPS6KB2
4415:RPS6KA4
4410:RPS6KA5
4061:Kalirin
4026:SNF1LK2
3265:EIF2AK4
3260:EIF2AK3
3114:Kinases
2955:Galanin
2603:Gremlin
2593:Decorin
2588:Chordin
2487:TGFBR3:
2449:TGFBR2:
2394:TGFBR1:
2377:Activin
1902:1224123
1731:6754765
1682:1224123
1507:1224123
1412:8256043
1389:Bibcode
1294:Ensembl
1273:Ensembl
1206:ovarian
1144:protein
902:UniProt
857:Ensembl
796:Species
775:QuickGO
369:pattern
95:Aliases
5232:Portal
5174:Lyases
4920:MAP2K7
4915:MAP2K6
4910:MAP2K5
4905:MAP2K4
4900:MAP2K3
4895:MAP2K2
4890:MAP2K1
4841:ACVRL1
4836:ACVR2B
4831:ACVR2A
4826:ACVR1C
4821:ACVR1B
4804:BMPR1B
4799:BMPR1A
4673:MAP3K7
4658:MAP3K9
4609:MAP3K8
4604:MAP3K7
4599:MAP3K6
4594:MAP3K5
4589:MAP3K4
4584:MAP3K3
4579:MAP3K2
4574:MAP3K1
4548:MAPK14
4543:MAPK13
4538:MAPK11
4526:MAPK10
4504:MAPK15
4499:MAPK12
4391:CDC2L1
4366:CDC2L5
4041:SNF1LK
3866:CAMK2G
3861:CAMK2D
3856:CAMK2B
3851:CAMK2A
3841:CAMK1G
3836:CAMK1D
3831:CAMK1B
3826:CAMK1A
3680:PRKCB1
3617:PRKACA
3612:PRKACB
3607:PRKACG
3583:IKBKAP
3409:BCKDHB
3404:BCKDHA
3378:PRKAG3
3373:PRKAG2
3368:PRKAG1
3358:PRKAB2
3353:PRKAB1
3343:PRKAA2
3338:PRKAA1
3183:STK38L
2651:Cripto
2618:Noggin
2550:I-SMAD
2520:R-SMAD
2466:ACVR2B
2461:ACVR2A
2438:BMPR1B
2433:BMPR1A
2423:ACVRL1
2416:ACVR1C
2411:ACVR1B
2385:family
2186:TGF-β3
2181:TGF-β2
2176:TGF-β1
2102:(MeSH)
2079:
2049:
2014:
1979:
1944:
1909:
1899:
1866:
1831:
1802:
1738:
1728:
1689:
1679:
1640:
1599:
1591:
1581:
1542:
1514:
1504:
1465:
1457:
1419:
1409:
1212:, and
1210:breast
1086:search
1084:PubMed
935:Q8K592
916:Q16671
845:110542
812:Entrez
540:BioGPS
452:spleen
127:105062
119:600956
5126:Types
4882:MAP2K
4816:ACVR1
4809:BMPR2
4794:BMPR1
4719:GSK-3
4560:MAP3K
4521:MAPK9
4516:MAPK8
4494:MAPK7
4489:MAPK6
4484:MAPK4
4479:MAPK3
4474:MAPK1
4386:PFTK1
4381:PCTK3
4376:PCTK2
4371:PCTK1
4361:CDK12
4356:CDK10
4331:CDKL5
4311:CDKL2
4188:STK19
4183:EEF2K
4164:PHKG2
4159:PHKG1
4149:PHKA2
4144:PHKA1
4125:MYLK4
4120:MYLK3
4115:MYLK2
4091:DCLK1
4086:Titin
4076:TRIB3
4071:TRIB2
4066:TRIB1
4056:TSSK2
4036:STK40
4021:PSKH1
4016:PRKD3
4011:PRKD2
3991:PHKG2
3986:PHKG1
3976:OBSCN
3971:NUAK2
3966:NUAK1
3961:MKNK2
3956:MKNK1
3946:MARK4
3941:MARK3
3936:MARK2
3931:MARK1
3911:STK11
3906:DAPK3
3901:DAPK2
3896:DAPK1
3891:CHEK2
3886:CHEK1
3871:CAMK4
3846:CAMK2
3821:CAMK1
3816:BRSK2
3710:PRKCQ
3705:PRKCI
3700:PRKCG
3695:PRKCH
3690:PRKCE
3685:PRKCD
3646:PRKG1
3578:IKBKG
3573:IKBKE
3522:STK10
3517:FASTK
3443:IDH3G
3438:IDH3B
3433:IDH3A
3399:BCKDK
3193:ROCK1
3178:STK38
3173:MAST2
3168:MAST1
3163:LATS2
3158:LATS1
3060:Sigma
3053:Other
2943:TACR1
2890:Kappa
2885:Delta
2822:Other
2660:Other
2646:BAMBI
2628:THBS1
2613:LTBP1
2608:Lefty
2565:SMAD4
2559:SMAD7
2554:SMAD6
2544:SMAD9
2539:SMAD5
2534:SMAD3
2529:SMAD2
2524:SMAD1
2478:BMPR2
2473:AMHR2
2428:BMPR1
2406:ACVR1
2351:GDF15
2346:GDF11
2341:GDF10
2289:BMP15
2284:BMP10
2279:BMP8b
2274:BMP8a
2220:Nodal
2213:INHBC
2208:INHBB
2203:INHBA
2163:TGFBR
1597:S2CID
1463:S2CID
1239:, or
1168:TGF-β
1142:is a
805:Mouse
800:Human
771:Amigo
490:ovary
392:Mouse
385:Human
332:Start
267:Mouse
231:Start
164:Human
143:AMHR2
135:10746
102:AMHR2
79:AMHR2
5218:list
5211:EC7
5205:list
5198:EC6
5192:list
5185:EC5
5179:list
5172:EC4
5166:list
5159:EC3
5153:list
5146:EC2
5140:list
5133:EC1
4709:TPK1
4685:CDC7
4643:MLKs
4636:KSR2
4631:KSR1
4626:BRAF
4621:ARAF
4616:RAFs
4351:CDK9
4346:CDK8
4341:CDK7
4336:CDK6
4326:CDK5
4321:CDK4
4316:CDK3
4306:CDK2
4301:CDK1
4282:PLK4
4277:PLK3
4272:PLK2
4267:PLK1
4222:PLK4
4217:PLK3
4212:PLK2
4207:PLK1
4154:PHKB
4110:MYLK
4081:TRIO
4051:SPEG
4046:SNRK
4006:PKD1
4001:PIM2
3996:PIM1
3981:PASK
3951:MELK
3881:CASK
3876:MLCK
3797:GRK6
3792:GRK5
3787:GRK4
3725:PKN3
3720:PKN2
3622:PRKY
3568:TBK1
3563:IKK2
3558:CHUK
3462:STK4
3428:IDH2
3313:PDK4
3308:PDK3
3303:PDK2
3298:PDK1
3277:WEE1
3272:Wee1
3240:mTOR
3228:AKT3
3223:AKT2
3218:AKT1
3208:SGK3
3203:SGK2
3042:NPR2
3037:NPR1
2834:NPR3
2808:LHCG
2753:LHRH
2667:SARA
2623:PARN
2512:SMAD
2336:GDF9
2326:GDF7
2321:GDF6
2316:GDF5
2311:GDF3
2306:GDF2
2301:GDF1
2269:BMP7
2264:BMP6
2259:BMP5
2254:BMP4
2249:BMP3
2244:BMP2
2231:BMPR
2198:INHA
2159:ACVR
2077:PMID
2047:PMID
2012:PMID
1977:PMID
1942:PMID
1907:PMID
1864:PMID
1829:PMID
1800:PMID
1736:PMID
1687:PMID
1638:PMID
1589:PMID
1540:PMID
1512:PMID
1455:PMID
1417:PMID
1370:7L0J
1185:gene
1183:The
1148:gene
375:Bgee
323:Band
284:Chr.
222:Band
181:Chr.
115:OMIM
4714:TTK
4678:ZAK
3255:HRI
3250:PKR
3198:SGK
3188:CIT
2965:B/W
2863:VIP
2813:TSH
2758:TRH
2748:FSH
2743:CRH
2381:BMP
2161:or
2069:doi
2065:108
2037:doi
2002:doi
1967:doi
1932:doi
1897:PMC
1889:doi
1885:379
1854:doi
1821:doi
1817:196
1790:doi
1726:PMC
1718:doi
1714:455
1677:PMC
1669:doi
1665:379
1628:doi
1579:PMC
1571:doi
1502:PMC
1494:doi
1490:379
1447:doi
1407:PMC
1397:doi
1385:118
1366:PDB
826:269
548:n/a
345:End
244:End
147:OMA
123:MGI
5258::
3364:γ
3349:β
3334:α
3122:EC
3116::
3009:GH
2970:FF
2931:B2
2926:B1
2895:Mu
2791:1B
2786:1A
2383:,
2379:,
2139::
2075:.
2063:.
2045:.
2033:22
2031:.
2027:.
2010:.
1998:22
1996:.
1992:.
1975:.
1963:22
1961:.
1957:.
1940:.
1928:22
1926:.
1922:.
1905:.
1895:.
1883:.
1879:.
1862:.
1850:78
1848:.
1844:.
1827:.
1798:.
1786:22
1784:.
1780:.
1734:.
1724:.
1712:.
1708:.
1685:.
1675:.
1663:.
1659:.
1636:.
1622:.
1618:.
1595:.
1587:.
1577:.
1567:57
1565:.
1561:.
1534:.
1510:.
1500:.
1488:.
1484:.
1461:.
1453:.
1441:.
1429:^
1415:.
1405:.
1395:.
1383:.
1379:.
1368::
1357:^
1327:.
1309:.
1280:^
1259:^
1231:.
1208:,
1150:.
773:/
351:bp
338:bp
250:bp
237:bp
145:;
141::
137:;
133::
129:;
125::
121:;
117::
5234::
5220:)
5216:(
5207:)
5203:(
5194:)
5190:(
5181:)
5177:(
5168:)
5164:(
5155:)
5151:(
5142:)
5138:(
4962:e
4955:t
4948:v
4771:-
4754:-
4737:-
3540:-
3120:(
3106:e
3099:t
3092:v
3070:2
3065:1
2980:Y
2975:S
2856:B
2851:A
2796:2
2701:e
2694:t
2687:v
2561:)
2552:(
2546:)
2522:(
2510:/
2387:)
2375:(
2129:e
2122:t
2115:v
2083:.
2071::
2053:.
2039::
2018:.
2004::
1983:.
1969::
1948:.
1934::
1913:.
1891::
1870:.
1856::
1835:.
1823::
1806:.
1792::
1760:.
1742:.
1720::
1693:.
1671::
1644:.
1630::
1624:5
1603:.
1573::
1546:.
1536:5
1518:.
1496::
1469:.
1449::
1443:7
1423:.
1399::
1391::
1351:.
1331:.
1313:.
269:)
166:)
149::
67:)
61:(
56:)
52:(
48:.
42:.
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