4035:
363:
340:
237:
262:
621:
614:
369:
268:
1830:. Paradoxically, carriers of this mutation have very low HDL-C (HDL-Cholesterol) levels, but no increase in the risk of heart disease, often living to age 100 or older. This unusual observation was what lead Italian investigators to track down what was going on and lead to the discovery of apoA-I Milano (the city, Milano, ~160 km away, in which the researcher's lab was located). Biochemically, apo A1 contains an extra
42:
1727:
The protein, as a component of HDL particles, enables efflux of fat molecules by accepting fats from within cells (including macrophages within the walls of arteries which have become overloaded with ingested fats from oxidized LDL particles) for transport (in the water outside cells) elsewhere,
1860:
A study from 2008 describes two novel susceptibility haplotypes, P2-S2-X1 and P1-S2-X1, discovered in ApoAI-CIII-AIV gene cluster on chromosome 11q23, which confer approximately threefold higher risk of coronary heart disease in normal as well as in the patients having type 2 diabetes mellitus.
1939:
Apolipoprotein AI and ApoE interact epistatically to modulate triglyceride levels in coronary heart disease patients. Individually, neither Apo-AI nor ApoE was found to be associated with triglyceride (TG) levels, but pairwise epistasis (additive x additive model) explored their significant
68:
3048:
Yamakawa-Kobayashi K, Yanagi H, Fukayama H, Hirano C, Shimakura Y, Yamamoto N, et al. (February 1999). "Frequent occurrence of hypoalphalipoproteinemia due to mutant apolipoprotein A-I gene in the population: a population-based survey".
2917:
McQueen MJ, Hawken S, Wang X, Ounpuu S, Sniderman A, Probstfield J, et al. (July 2008). "Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study".
3431:
Maezawa I, Jin LW, Woltjer RL, Maeda N, Martin GM, Montine TJ, et al. (December 2004). "Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-associated cytotoxicity".
1694:, with its specific location being 11q23-q24. The gene contains 4 exons. The encoded apolipoprotein AI, is a 28.1 kDa protein composed of 243 amino acids; 21 peptides have been observed through mass spectrometry data. Due to
3344:
Singh P, Singh M, Gaur S, Kaur T (June 2007). "The ApoAI-CIII-AIV gene cluster and its relation to lipid levels in type 2 diabetes mellitus and coronary heart disease: determination of a novel susceptible haplotype".
2634:
Arinami T, Hirano T, Kobayashi K, Yamanouchi Y, Hamaguchi H (June 1990). "Assignment of the apolipoprotein A-I gene to 11q23 based on RFLP in a case with a partial deletion of chromosome 11, del(11)(q23.3----qter)".
2020:
contains a domain not present in any eukaryotic ortholog. This domain has a high sequence identity to APOA1BP. CARKD is a protein of unknown function, and the biochemical basis for this interaction is unknown.
1826:, Italy, and, by genetic + church record family tree detective work, traced to a single individual, Giovanni Pomarelli, in the 18th century. Described in 1980, it was the first known molecular abnormality of
3012:
Dastani Z, Dangoisse C, Boucher B, Desbiens K, Krimbou L, Dufour R, et al. (March 2006). "A novel nonsense apolipoprotein A-I mutation (apoA-I(E136X)) causes low HDL cholesterol in French
Canadians".
2358:
2046:
2825:
Wasan KM, Brocks DR, Lee SD, Sachs-Barrable K, Thornton SJ (January 2008). "Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery".
1758:(LDL)/(HDL) particle ratios even more so, has always had a stronger correlation with myocardial infarction event rates than older methods of measuring lipid transport in the water outside cells.
3664:
Lahoz C, Peña R, Mostaza JM, Jiménez J, Subirats E, Pintó X, et al. (June 2003). "Apo A-I promoter polymorphism influences basal HDL-cholesterol and its response to pravastatin therapy".
1849:
in animal models by up to 30%. Apo-AI Milano has also been shown in small clinical trials to have a statistically significant effect in reducing (reversing) plaque build-up on arterial walls.
1842:
with Apo-AII. However, the enhanced cardioprotective activity of this mutant (which likely depends on fat & cholesterol efflux) cannot easily be replicated by other cysteine mutants.
3822:
1754:
Apo-AI is often used as a biomarker for prediction of cardiovascular diseases. The ratio apoB-100/apoA-I (i.e. LDL & larger particles vs. HDL particles), NMR measured lipoprotein (
1806:, from white blood cells within artery walls, making the white blood cells (WBCs) less likely to become fat overloaded, transform into foam cells, die and contribute to progressive
3475:
Solomon A, Murphy CL, Kestler D, Coriu D, Weiss DT, Makovitzky J, et al. (November 2006). "Amyloid contained in the knee joint meniscus is formed from apolipoprotein A-I".
4257:
4237:
3629:
Wehmeier K, Beers A, Haas MJ, Wong NC, Steinmeyer A, Zugel U, et al. (October 2005). "Inhibition of apolipoprotein AI gene expression by 1, 25-dihydroxyvitamin D3".
3309:
Singh P, Singh M, Kaur TP, Grewal SS (November 2008). "A novel haplotype in ApoAI-CIII-AIV gene region is detrimental to
Northwest Indians with coronary heart disease".
3098:
Franceschini G, Sirtori M, Gianfranceschi G, Sirtori CR (May 1981). "Relation between the HDL apoproteins and AI isoproteins in subjects with the AIMilano abnormality".
376:
275:
3941:
3388:
Vollbach H, Heun R, Morris CM, Edwardson JA, McKeith IG, Jessen F, et al. (September 2005). "APOA1 polymorphism influences risk for early-onset nonfamiliar AD".
4285:
4034:
2746:
1952:. It was concluded, that this regulation happens on transcription level: calcitriol alters yet unknown coactivators or corepressors, resulting in repression of
3783:"Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I"
1359:
198:
1340:
4147:
3220:
1743:(PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including
1732:
4180:
1814:. One of four mutants of Apo-AI is present in roughly 0.3% of the Japanese population, but is found in 6% of those with low HDL cholesterol levels.
3594:
Singh P, Singh M, Kaur T (May 2009). "Role of apolipoproteins E and A-I: epistatic villains of triglyceride mediation in coronary heart disease".
2398:
2086:
2401:
2089:
3826:
2371:
2059:
4336:
2793:
2557:
65:
2963:"Cell-Free Co-Translational Approaches for Producing Mammalian Receptors: Expanding the Cell-Free Expression Toolbox Using Nanolipoproteins"
4212:
3934:
2539:
2370:
2058:
3244:"Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial"
2389:
2077:
1595:
362:
3859:
3701:"Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I"
3547:"Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues"
2405:
2093:
4175:
1602:
339:
2391:
2079:
1963:
treatment may cause an increase in HDL-C levels by inducing Apo-AI production, but this depends on the G/A promoter polymorphism.
4295:
3998:
2683:
2402:
2090:
3927:
2526:
2505:
261:
236:
2522:
2368:
2056:
3865:
2754:
2404:
2384:
2378:
2373:
2092:
2072:
2066:
2061:
4185:
4167:
2396:
2376:
2084:
2064:
2501:
3984:
2428:
2369:
2057:
178:
3283:
2387:
2386:
2365:
2075:
2074:
2053:
1972:
1724:
secreted from the intestinal enterocyte also contain Apo-AI, but it is quickly transferred to HDL in the bloodstream.
2406:
2395:
2382:
2381:
2380:
2094:
2083:
2070:
2069:
2068:
375:
274:
2399:
2385:
2087:
2073:
2403:
2400:
2091:
2088:
368:
267:
2870:"Serum prostacyclin stabilizing factor is identical to apolipoprotein A-I (Apo A-I). A novel function of Apo A-I"
2383:
2071:
3510:
Ma J, Liao XL, Lou B, Wu MP (June 2004). "Role of apolipoprotein A-I in protecting against endotoxin toxicity".
2409:
2408:
2366:
2362:
2097:
2096:
2054:
2050:
2009:
1810:. Five of nine men found to carry a mutation (E164X) who were at least 35 years of age had developed premature
4341:
4019:
3847:
2407:
2397:
2394:
2393:
2392:
2377:
2375:
2374:
2372:
2364:
2363:
2361:
2095:
2085:
2082:
2081:
2080:
2065:
2063:
2062:
2060:
2052:
2051:
2049:
1795:
1711:
1672:
1404:
186:
2390:
2379:
2367:
2078:
2067:
2055:
2388:
2076:
4003:
3853:
1811:
1755:
1385:
2472:
1870:
3135:"Cysteine mutants of human apolipoprotein A-I: a study of secondary structural and functional properties"
4195:
250:
1956:
promoter activity. Simultaneously, Apo-AI production was increased by vitamin D antagonist, ZK-191784.
1885:
is presented. Protection from
Alzheimer's disease by Apo-AI may rely on a synergistic interaction with
2588:
1695:
1557:
1553:
3084:
4024:
3871:
3545:
Huang JT, Wang L, Prabakaran S, Wengenroth M, Lockstone HE, Koethe D, et al. (December 2008).
1928:
1539:
1535:
1531:
1486:
1482:
1478:
165:
2013:
1543:
4157:
3576:
3457:
3413:
3370:
3199:
2943:
2850:
2807:
2660:
2575:
Breslow JL, Ross D, McPherson J, Williams H, Kurnit D, Nussbaum AL, et al. (November 1982).
1913:
1874:
1736:
210:
3242:
Nissen SE, Tsunoda T, Tuzcu EM, Schoenhagen P, Cooper CJ, Yasin M, et al. (November 2003).
1578:
1527:
1507:
1474:
4099:
4094:
4089:
4084:
3994:
3899:
3878:
3843:
3804:
3781:
Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, et al. (January 1998).
3763:
3722:
3681:
3646:
3611:
3568:
3527:
3492:
3449:
3405:
3362:
3326:
3265:
3191:
3156:
3115:
3066:
3030:
2994:
2935:
2899:
2842:
2799:
2789:
2728:
2652:
2616:
1882:
620:
613:
158:
58:
4126:
4116:
4111:
4106:
4076:
3794:
3753:
3712:
3673:
3638:
3603:
3558:
3519:
3484:
3441:
3397:
3354:
3318:
3255:
3183:
3146:
3107:
3058:
3022:
2984:
2974:
2927:
2889:
2881:
2834:
2781:
2778:
Vertebrate and
Invertebrate Respiratory Proteins, Lipoproteins and other Body Fluid Proteins
2718:
2710:
2644:
2606:
2596:
2467:
1886:
1852:
In human trials the reversal of plaque build-up was measured over the course of five weeks.
1823:
1676:
455:
386:
330:
285:
4272:
4247:
206:
4121:
3919:
3026:
1744:
430:
3699:
Fitzgerald ML, Morris AL, Rhee JS, Andersson LP, Mendez AJ, Freeman MW (September 2002).
3742:"GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex"
2592:
41:
4152:
4043:
4014:
3174:
Chiesa G, Sirtori CR (April 2003). "Apolipoprotein A-I(Milano): current perspectives".
2989:
2962:
2723:
2698:
1827:
3799:
3782:
3758:
3741:
3677:
2931:
2894:
2869:
2611:
2576:
2449:
2432:
2419:
1274:
1269:
1264:
1259:
1254:
1249:
1244:
1239:
1234:
1229:
1224:
1219:
1214:
1209:
1204:
1199:
1194:
1189:
1184:
1179:
1174:
1169:
1164:
1159:
1154:
1149:
1144:
1139:
1134:
1129:
1124:
1119:
1114:
1109:
1104:
1099:
1094:
1089:
1084:
1079:
1074:
1069:
1064:
1059:
1054:
1049:
1044:
1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
682:
677:
672:
667:
662:
4330:
3908:
3887:
3445:
3187:
3111:
2811:
2699:"Integration of cardiac proteome biology and medicine by a specialized knowledgebase"
2477:
1924:
1818:
1691:
649:
3461:
3417:
3374:
3203:
2947:
2664:
2357:
2045:
4280:
3975:
3580:
2854:
1894:
1766:
1740:
1715:
448:
227:
2714:
190:
3642:
3607:
3322:
2785:
1893:
deposited in the knee following surgery consists largely of Apo-AI secreted from
214:
3990:
3979:
3963:
3954:
2868:
Yui Y, Aoyama T, Morishita H, Takahashi M, Takatsu Y, Kawai C (September 1988).
2562:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2544:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1902:
1839:
1803:
1748:
1721:
3151:
3134:
2581:
Proceedings of the
National Academy of Sciences of the United States of America
531:
2030:
Click on genes, proteins and metabolites below to link to respective articles.
1949:
347:
244:
194:
3260:
3243:
2979:
2697:
Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, et al. (October 2013).
1948:
In a study from 2005 it was reported, that Apo-AI production is decreased by
3523:
2776:
van der Vorst EP (2020). "High-Density
Lipoproteins and Apolipoprotein A1".
2601:
2577:"Isolation and characterization of cDNA clones for human apolipoprotein A-I"
1917:
1898:
1835:
1304:
591:
469:
414:
401:
313:
300:
202:
3767:
3726:
3717:
3700:
3685:
3650:
3615:
3572:
3531:
3496:
3453:
3409:
3366:
3330:
3287:
3269:
3195:
3160:
3034:
2998:
2939:
2846:
2803:
2732:
3808:
3631:
Biochimica et
Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
3563:
3546:
3358:
3119:
3070:
3062:
2903:
2656:
2620:
1642:
1637:
1846:
1831:
1807:
1778:
1626:
1449:
1430:
3913:
3903:
3892:
3882:
2648:
2001:
1890:
1661:
1416:
1371:
1150:
negative regulation of tumor necrosis factor-mediated signaling pathway
1125:
negative regulation of very-low-density lipoprotein particle remodeling
3488:
3401:
2885:
2000:
Apolipoprotein AI binding precursor, a relative of APOA-1 abbreviated
1845:
Recombinant Apo-AI Milano dimers formulated into liposomes can reduce
1822:
is a naturally occurring mutant of Apo-AI, found in a few families in
1025:
negative regulation of cytokine production involved in immune response
135:
131:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
4204:
4139:
1960:
1790:
Activity associated with high HDL-C and protection from heart disease
1610:
1326:
17:
2838:
169:, entrez:335, apo(a), apolipoprotein A1, Apolipoprotein A-I, HPALP2
4315:
4310:
4305:
4267:
4262:
4222:
4069:
4064:
4059:
3950:
2008:. The relationship between these two proteins is substantiated by
2005:
1984:
1979:
1762:
1190:
positive regulation of substrate adhesion-dependent cell spreading
1289:
1285:
4252:
4242:
4232:
4227:
4217:
1989:
1668:
182:
3923:
1856:
Novel haplotypes within apolipoprotein AI-CIII-AIV gene cluster
1728:
including back to LDL particles or to the liver for excretion.
688:
phosphatidylcholine-sterol O-acyltransferase activator activity
1920:, and has a major role in the anti-endotoxin function of HDL.
1702:, including at least one which encodes a Apo-AI preprotein.
629:
2961:
Shelby ML, He W, Dang AT, Kuhl TL, Coleman MA (3 July 2019).
1940:
synergistic contributions with raised TG levels (P<0.01).
1735:(LCAT) which is responsible for the formation of most plasma
3898:
Overview of all the structural information available in the
3877:
Overview of all the structural information available in the
2780:. Subcellular Biochemistry. Vol. 94. pp. 399–420.
2356:
2044:
2447:
The interactive pathway map can be edited at WikiPathways:
3823:"STRING: Known and Predicted Protein-Protein Interactions"
1923:
In one study, a decrease in Apo-AI levels was detected in
1005:
transforming growth factor beta receptor signaling pathway
1761:
Apo-AI is routinely measured using immunoassays such as
970:
negative regulation of cell adhesion molecule production
438:
3085:"The Long Saga of Apo-A1 Milano | in the Pipeline"
2751:
Cardiac
Organellar Protein Atlas Knowledgebase (COPaKB)
1030:
positive regulation of fatty acid biosynthetic process
905:
positive regulation of Rho protein signal transduction
1050:
positive regulation of triglyceride catabolic process
1000:
negative regulation of heterotypic cell-cell adhesion
603:
1710:
Apolipoprotein AI is the major protein component of
1180:
negative regulation of response to cytokine stimulus
4294:
4194:
4166:
4137:
4042:
3962:
3215:
3213:
1571:
1526:
1500:
1467:
2518:
2516:
2514:
2497:
2495:
2493:
1777:Apo-AI can be used to create in vitro lipoprotein
1075:positive regulation of lipoprotein lipase activity
678:high-density lipoprotein particle receptor binding
1265:positive regulation of lipid biosynthetic process
930:positive regulation of cholesterol esterification
385:
284:
3133:Zhu X, Wu G, Zeng W, Xue H, Chen B (June 2005).
1739:. Apolipoprotein AI has also been isolated as a
1250:very-low-density lipoprotein particle remodeling
2360:
2048:
2004:, has a predicted biochemical interaction with
1881:gene has been associated with the age at which
1698:, there exists multiple transcript variants of
1140:regulation of Cdc42 protein signal transduction
965:regulation of intestinal cholesterol absorption
3286:. Cedars-Sinai Heart Institute. Archived from
2523:GRCm38: Ensembl release 89: ENSMUSG00000032083
3935:
3740:Deeg MA, Bierman EL, Cheung MC (March 2001).
2006:carbohydrate kinase domain containing protein
8:
1210:positive regulation of stress fiber assembly
1185:high-density lipoprotein particle remodeling
1045:G protein-coupled receptor signaling pathway
1010:negative regulation of inflammatory response
2502:GRCh38: Ensembl release 89: ENSG00000118137
1781:for cell-free membrane expression systems.
1035:high-density lipoprotein particle clearance
975:peripheral nervous system axon regeneration
854:spherical high-density lipoprotein particle
814:discoidal high-density lipoprotein particle
3942:
3928:
3920:
1523:
1300:
1275:positive regulation of phospholipid efflux
1175:high-density lipoprotein particle assembly
645:
426:
325:
222:
76:
3846:at the U.S. National Library of Medicine
3798:
3757:
3716:
3562:
3259:
3221:"Apo A-I-Milano Trial: Where are we now?"
3150:
2988:
2978:
2893:
2722:
2610:
2600:
1802:), Apo-AI helps to clear fats, including
1230:positive regulation of cholesterol efflux
1135:positive regulation of hydrolase activity
945:negative regulation of hydrolase activity
884:intermediate-density lipoprotein particle
748:high-density lipoprotein particle binding
570:fetal liver hematopoietic progenitor cell
3347:Diabetes & Vascular Disease Research
2678:
2676:
2674:
1115:phosphatidylcholine biosynthetic process
889:collagen-containing extracellular matrix
2489:
2440:
1260:post-translational protein modification
1145:blood vessel endothelial cell migration
2684:"Entrez Gene: APOA1 apolipoprotein A1"
960:negative regulation of lipase activity
31:
3854:Applied Research on Apolipoprotein-A1
3027:10.1016/j.atherosclerosis.2005.05.028
2874:The Journal of Clinical Investigation
1675:particles, it has a specific role in
1235:regulation of lipid metabolic process
910:regulation of protein phosphorylation
819:very-low-density lipoprotein particle
390:
351:
346:
289:
248:
243:
7:
3512:Acta Biochimica et Biophysica Sinica
1971:Apolipoprotein A1 has been shown to
1747:, and with systemic non-neuropathic
1733:lecithin–cholesterol acyltransferase
3705:The Journal of Biological Chemistry
3596:International Journal of Cardiology
3311:International Journal of Cardiology
1270:positive regulation of phagocytosis
1240:regulation of cholesterol transport
1110:integrin-mediated signaling pathway
698:apolipoprotein A-I receptor binding
574:migratory enteric neural crest cell
3912:(Mouse Apolipoprotein A-I) at the
3891:(Human Apolipoprotein A-I) at the
1905:symptoms are associated with rare
1800:protective "fat removal" particles
1568:
1497:
1464:
1440:
1421:
1395:
1376:
1350:
1331:
608:
526:
464:
443:
25:
1944:Factors affecting Apo-AI activity
1834:bridge, causing it to exist as a
1664:that in humans is encoded by the
864:high-density lipoprotein particle
718:phospholipid transporter activity
4033:
3446:10.1111/j.1471-4159.2004.02818.x
3188:10.1097/00041433-200304000-00007
1931:, brain and peripheral tissues.
1225:lipoprotein biosynthetic process
1205:cholesterol biosynthetic process
1060:glucocorticoid metabolic process
990:peptidyl-methionine modification
879:low-density lipoprotein particle
619:
612:
374:
367:
361:
338:
273:
266:
260:
235:
40:
27:Protein used in lipid metabolism
673:apolipoprotein receptor binding
2827:Nature Reviews. Drug Discovery
1195:phospholipid metabolic process
1120:neuron projection regeneration
1090:triglyceride catabolic process
980:endothelial cell proliferation
630:More reference expression data
592:More reference expression data
1:
3800:10.1016/S0022-2275(20)34211-5
3759:10.1016/S0022-2275(20)31669-2
3678:10.1016/S0021-9150(03)00094-7
3176:Current Opinion in Lipidology
2932:10.1016/S0140-6736(08)61076-4
2715:10.1161/CIRCRESAHA.113.301151
1220:reverse cholesterol transport
1080:cholesterol metabolic process
1040:lipoprotein metabolic process
950:receptor-mediated endocytosis
708:cholesterol transfer activity
359:
258:
4337:Genes on human chromosome 11
3643:10.1016/j.bbalip.2005.09.004
3608:10.1016/j.ijcard.2007.12.102
3323:10.1016/j.ijcard.2007.07.029
3112:10.1016/0026-0495(81)90188-8
2786:10.1007/978-3-030-41769-7_16
1794:As a major component of the
1671:. As the major component of
683:lipoprotein particle binding
2973:. Frontiers Media SA: 744.
2016:. The ortholog of CARKD in
784:endoplasmic reticulum lumen
668:phosphatidylcholine binding
4358:
3870:gene details page in the
3152:10.1194/jlr.M400401-JLR200
2010:cooccurance across genomes
1996:Potential binding partners
1935:Epistatic impact of Apo-AI
1901:cells). A wide variety of
1596:Chr 11: 116.84 – 116.84 Mb
955:retinoid metabolic process
763:signaling receptor binding
758:heat shock protein binding
733:lipid transporter activity
4031:
3787:Journal of Lipid Research
3746:Journal of Lipid Research
3434:Journal of Neurochemistry
3139:Journal of Lipid Research
2967:Frontiers in Pharmacology
2558:"Mouse PubMed Reference:"
2540:"Human PubMed Reference:"
1641:
1636:
1632:
1625:
1609:
1590:
1575:
1550:
1519:
1504:
1471:
1460:
1447:
1443:
1428:
1424:
1415:
1402:
1398:
1383:
1379:
1370:
1357:
1353:
1338:
1334:
1325:
1310:
1303:
1299:
1283:
1170:adrenal gland development
1130:steroid metabolic process
985:animal organ regeneration
743:identical protein binding
663:lipase inhibitor activity
648:
644:
627:
611:
602:
589:
538:
529:
476:
467:
437:
429:
425:
408:
395:
358:
337:
328:
324:
307:
294:
257:
234:
225:
221:
176:
173:
163:
156:
151:
84:
79:
62:
57:
52:
48:
39:
34:
3848:Medical Subject Headings
3477:Arthritis and Rheumatism
3261:10.1001/jama.290.17.2292
3051:Human Molecular Genetics
2980:10.3389/fphar.2019.00744
1796:high-density lipoprotein
1712:high density lipoprotein
1215:triglyceride homeostasis
1015:phospholipid homeostasis
4168:Lipid transfer proteins
2602:10.1073/pnas.79.22.6861
2025:Interactive pathway map
1812:coronary artery disease
1756:low density lipoprotein
1603:Chr 9: 46.14 – 46.14 Mb
1095:transmembrane transport
995:cholesterol homeostasis
829:secretory granule lumen
809:endocytic vesicle lumen
728:chemorepellent activity
4196:Cell surface receptors
3718:10.1074/jbc.M204996200
2473:Cardiovascular disease
2450:"Statin_Pathway_WP430"
2412:
2100:
1865:Role in other diseases
1245:chylomicron remodeling
1165:platelet degranulation
940:phospholipid transport
578:mucous cell of stomach
392:9 A5.2|9 25.36 cM
3564:10.1038/sj.mp.4002108
3524:10.1093/abbs/36.6.419
3359:10.3132/dvdr.2007.030
2747:"Apolipoprotein A-IV"
2411:
2099:
1785:Clinical significance
1731:It is a cofactor for
1160:cholesterol transport
1070:protein stabilization
1020:ERK1 and ERK2 cascade
834:extracellular exosome
804:extracellular vesicle
558:epithelium of stomach
251:Chromosome 11 (human)
4298:cassette transporter
3864:genome location and
3551:Molecular Psychiatry
2703:Circulation Research
2418:|alt=Statin pathway
1696:alternative splicing
1255:chylomicron assembly
1085:response to estrogen
1055:response to nutrient
794:extracellular region
713:amyloid-beta binding
693:phospholipid binding
353:Chromosome 9 (mouse)
80:List of PDB id codes
53:Available structures
4025:Remnant cholesterol
3957:particle metabolism
3872:UCSC Genome Browser
3711:(36): 33178–33187.
3390:Annals of Neurology
3290:on 21 December 2007
3087:. 16 November 2016.
3063:10.1093/hmg/8.2.331
2593:1982PNAS...79.6861B
1714:(HDL) particles in
935:phospholipid efflux
925:negative chemotaxis
874:extracellular space
869:cytoplasmic vesicle
839:blood microparticle
738:cholesterol binding
484:right lobe of liver
3844:Apolipoprotein+A-I
3223:. Cleveland Clinic
2649:10.1007/BF00276323
2413:
2101:
1914:lipopolysaccharide
1737:cholesteryl esters
1405:ENSMUSG00000032083
1105:cholesterol efflux
915:cholesterol import
898:Biological process
772:Cellular component
656:Molecular function
542:left lobe of liver
4324:
4323:
3557:(12): 1118–1128.
3489:10.1002/art.22201
3483:(11): 3545–3550.
3402:10.1002/ana.20593
3254:(17): 2292–2300.
2926:(9634): 224–233.
2886:10.1172/JCI113682
2795:978-3-030-41768-0
2587:(22): 6861–6865.
1883:Alzheimer disease
1655:Apolipoprotein AI
1652:
1651:
1648:
1647:
1621:
1620:
1586:
1585:
1565:
1564:
1515:
1514:
1494:
1493:
1456:
1455:
1437:
1436:
1411:
1410:
1392:
1391:
1366:
1365:
1347:
1346:
1295:
1294:
1200:vitamin transport
844:endocytic vesicle
640:
639:
636:
635:
598:
597:
585:
584:
523:
522:
421:
420:
320:
319:
215:APOA1 - orthologs
147:
146:
143:
142:
63:Ortholog search:
16:(Redirected from
4349:
4037:
3966:particle classes
3944:
3937:
3930:
3921:
3831:
3830:
3829:on 18 July 2011.
3825:. Archived from
3819:
3813:
3812:
3802:
3778:
3772:
3771:
3761:
3737:
3731:
3730:
3720:
3696:
3690:
3689:
3661:
3655:
3654:
3626:
3620:
3619:
3591:
3585:
3584:
3566:
3542:
3536:
3535:
3507:
3501:
3500:
3472:
3466:
3465:
3440:(6): 1312–1321.
3428:
3422:
3421:
3385:
3379:
3378:
3341:
3335:
3334:
3306:
3300:
3299:
3297:
3295:
3284:"Apo A-I Milano"
3280:
3274:
3273:
3263:
3239:
3233:
3232:
3230:
3228:
3217:
3208:
3207:
3171:
3165:
3164:
3154:
3145:(6): 1303–1311.
3130:
3124:
3123:
3095:
3089:
3088:
3081:
3075:
3074:
3045:
3039:
3038:
3009:
3003:
3002:
2992:
2982:
2958:
2952:
2951:
2914:
2908:
2907:
2897:
2865:
2859:
2858:
2822:
2816:
2815:
2773:
2767:
2766:
2764:
2762:
2753:. Archived from
2743:
2737:
2736:
2726:
2709:(9): 1043–1053.
2694:
2688:
2687:
2680:
2669:
2668:
2631:
2625:
2624:
2614:
2604:
2572:
2566:
2565:
2554:
2548:
2547:
2536:
2530:
2520:
2509:
2499:
2468:Apolipoprotein B
2454:
2453:
2445:
2352:
2347:
2342:
2337:
2332:
2327:
2322:
2317:
2312:
2307:
2302:
2297:
2292:
2287:
2282:
2277:
2272:
2267:
2262:
2257:
2252:
2247:
2242:
2237:
2232:
2227:
2222:
2217:
2212:
2207:
2202:
2197:
2192:
2187:
2182:
2177:
2172:
2167:
2162:
2157:
2152:
2147:
2142:
2137:
2132:
2127:
2122:
2117:
2112:
2107:
1912:Apo-AI binds to
1887:alpha-tocopherol
1824:Limone sul Garda
1677:lipid metabolism
1634:
1633:
1605:
1598:
1581:
1569:
1560:
1524:
1520:RefSeq (protein)
1510:
1498:
1489:
1465:
1441:
1422:
1396:
1377:
1351:
1332:
1301:
1155:lipid metabolism
646:
632:
623:
616:
609:
594:
534:
532:Top expressed in
527:
472:
470:Top expressed in
465:
444:
427:
417:
404:
393:
378:
371:
365:
354:
342:
326:
316:
303:
292:
277:
270:
264:
253:
239:
223:
217:
168:
161:
138:
77:
71:
50:
49:
44:
32:
21:
4357:
4356:
4352:
4351:
4350:
4348:
4347:
4346:
4342:Apolipoproteins
4327:
4326:
4325:
4320:
4297:
4290:
4190:
4162:
4133:
4044:Apolipoproteins
4038:
4029:
3967:
3958:
3948:
3840:
3835:
3834:
3821:
3820:
3816:
3780:
3779:
3775:
3739:
3738:
3734:
3698:
3697:
3693:
3666:Atherosclerosis
3663:
3662:
3658:
3628:
3627:
3623:
3593:
3592:
3588:
3544:
3543:
3539:
3509:
3508:
3504:
3474:
3473:
3469:
3430:
3429:
3425:
3387:
3386:
3382:
3343:
3342:
3338:
3308:
3307:
3303:
3293:
3291:
3282:
3281:
3277:
3241:
3240:
3236:
3226:
3224:
3219:
3218:
3211:
3173:
3172:
3168:
3132:
3131:
3127:
3097:
3096:
3092:
3083:
3082:
3078:
3047:
3046:
3042:
3015:Atherosclerosis
3011:
3010:
3006:
2960:
2959:
2955:
2916:
2915:
2911:
2867:
2866:
2862:
2839:10.1038/nrd2353
2824:
2823:
2819:
2796:
2775:
2774:
2770:
2760:
2758:
2757:on 5 March 2016
2745:
2744:
2740:
2696:
2695:
2691:
2682:
2681:
2672:
2633:
2632:
2628:
2574:
2573:
2569:
2556:
2555:
2551:
2538:
2537:
2533:
2521:
2512:
2500:
2491:
2486:
2464:
2459:
2458:
2457:
2448:
2446:
2442:
2437:
2436:
2435:
2431:Statin pathway
2430:
2425:
2424:
2423:
2417:
2416:
2415:
2414:
2410:
2354:
2353:
2350:
2348:
2345:
2343:
2340:
2338:
2335:
2333:
2330:
2328:
2325:
2323:
2320:
2318:
2315:
2313:
2310:
2308:
2305:
2303:
2300:
2298:
2295:
2293:
2290:
2288:
2285:
2283:
2280:
2278:
2275:
2273:
2270:
2268:
2265:
2263:
2260:
2258:
2255:
2253:
2250:
2248:
2245:
2243:
2240:
2238:
2235:
2233:
2230:
2228:
2225:
2223:
2220:
2218:
2215:
2213:
2210:
2208:
2205:
2203:
2200:
2198:
2195:
2193:
2190:
2188:
2185:
2183:
2180:
2178:
2175:
2173:
2170:
2168:
2165:
2163:
2160:
2158:
2155:
2153:
2150:
2148:
2145:
2143:
2140:
2138:
2135:
2133:
2130:
2128:
2125:
2123:
2120:
2118:
2115:
2113:
2110:
2108:
2105:
2102:
2098:
2027:
1998:
1969:
1946:
1937:
1867:
1858:
1828:apolipoproteins
1792:
1787:
1775:
1745:Tangier disease
1708:
1685:
1643:View/Edit Mouse
1638:View/Edit Human
1601:
1594:
1591:Location (UCSC)
1577:
1556:
1552:
1546:
1542:
1538:
1534:
1530:
1506:
1485:
1481:
1477:
1473:
1386:ENSG00000118137
1279:
920:lipid transport
893:
849:plasma membrane
767:
723:protein binding
628:
618:
617:
590:
581:
576:
572:
568:
564:
560:
556:
552:
548:
544:
530:
519:
514:
510:
506:
502:
498:
494:
490:
488:mucosa of ileum
486:
482:
468:
412:
399:
391:
381:
380:
379:
372:
352:
329:Gene location (
311:
298:
290:
280:
279:
278:
271:
249:
226:Gene location (
177:
164:
157:
86:
64:
28:
23:
22:
15:
12:
11:
5:
4355:
4353:
4345:
4344:
4339:
4329:
4328:
4322:
4321:
4319:
4318:
4313:
4308:
4302:
4300:
4292:
4291:
4289:
4288:
4283:
4277:
4276:
4275:
4270:
4265:
4260:
4255:
4250:
4245:
4240:
4235:
4230:
4225:
4220:
4208:
4207:
4200:
4198:
4192:
4191:
4189:
4188:
4183:
4178:
4172:
4170:
4164:
4163:
4161:
4160:
4155:
4150:
4144:
4142:
4138:Extracellular
4135:
4134:
4132:
4131:
4130:
4129:
4119:
4114:
4109:
4104:
4103:
4102:
4097:
4092:
4087:
4079:
4074:
4073:
4072:
4067:
4062:
4057:
4048:
4046:
4040:
4039:
4032:
4030:
4028:
4027:
4022:
4017:
4012:
4009:
4006:
4001:
3987:
3982:
3971:
3969:
3968:and subclasses
3960:
3959:
3949:
3947:
3946:
3939:
3932:
3924:
3918:
3917:
3896:
3875:
3856:
3851:
3839:
3838:External links
3836:
3833:
3832:
3814:
3793:(1): 152–161.
3773:
3752:(3): 442–451.
3732:
3691:
3672:(2): 289–295.
3656:
3621:
3602:(3): 410–412.
3586:
3537:
3518:(6): 419–424.
3502:
3467:
3423:
3396:(3): 436–441.
3380:
3353:(2): 124–129.
3336:
3317:(3): e93–e95.
3301:
3275:
3234:
3209:
3182:(2): 159–163.
3166:
3125:
3106:(5): 502–509.
3090:
3076:
3057:(2): 331–336.
3040:
3021:(1): 127–136.
3004:
2953:
2909:
2880:(3): 803–807.
2860:
2817:
2794:
2768:
2738:
2689:
2670:
2637:Human Genetics
2626:
2567:
2549:
2531:
2510:
2488:
2487:
2485:
2482:
2481:
2480:
2475:
2470:
2463:
2460:
2456:
2455:
2439:
2438:
2427:
2426:
2355:
2349:
2344:
2339:
2334:
2329:
2324:
2319:
2314:
2309:
2304:
2299:
2294:
2289:
2284:
2279:
2274:
2269:
2264:
2259:
2254:
2249:
2244:
2239:
2234:
2229:
2224:
2219:
2214:
2209:
2204:
2199:
2194:
2189:
2184:
2179:
2174:
2169:
2164:
2159:
2154:
2149:
2144:
2139:
2134:
2129:
2124:
2119:
2114:
2109:
2104:
2103:
2043:
2042:
2041:
2040:
2038:
2037:
2036:
2035:
2034:
2033:
2026:
2023:
1997:
1994:
1993:
1992:
1987:
1982:
1968:
1965:
1945:
1942:
1936:
1933:
1866:
1863:
1857:
1854:
1791:
1788:
1786:
1783:
1774:
1771:
1707:
1704:
1690:is located on
1684:
1681:
1650:
1649:
1646:
1645:
1640:
1630:
1629:
1623:
1622:
1619:
1618:
1616:
1614:
1607:
1606:
1599:
1592:
1588:
1587:
1584:
1583:
1573:
1572:
1566:
1563:
1562:
1558:NP_001304947.1
1554:NP_001304946.1
1548:
1547:
1521:
1517:
1516:
1513:
1512:
1502:
1501:
1495:
1492:
1491:
1469:
1468:
1462:
1458:
1457:
1454:
1453:
1445:
1444:
1438:
1435:
1434:
1426:
1425:
1419:
1413:
1412:
1409:
1408:
1400:
1399:
1393:
1390:
1389:
1381:
1380:
1374:
1368:
1367:
1364:
1363:
1355:
1354:
1348:
1345:
1344:
1336:
1335:
1329:
1323:
1322:
1317:
1312:
1308:
1307:
1297:
1296:
1293:
1292:
1281:
1280:
1278:
1277:
1272:
1267:
1262:
1257:
1252:
1247:
1242:
1237:
1232:
1227:
1222:
1217:
1212:
1207:
1202:
1197:
1192:
1187:
1182:
1177:
1172:
1167:
1162:
1157:
1152:
1147:
1142:
1137:
1132:
1127:
1122:
1117:
1112:
1107:
1102:
1097:
1092:
1087:
1082:
1077:
1072:
1067:
1062:
1057:
1052:
1047:
1042:
1037:
1032:
1027:
1022:
1017:
1012:
1007:
1002:
997:
992:
987:
982:
977:
972:
967:
962:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
901:
899:
895:
894:
892:
891:
886:
881:
876:
871:
866:
861:
859:early endosome
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
775:
773:
769:
768:
766:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
703:enzyme binding
700:
695:
690:
685:
680:
675:
670:
665:
659:
657:
653:
652:
642:
641:
638:
637:
634:
633:
625:
624:
606:
600:
599:
596:
595:
587:
586:
583:
582:
580:
579:
575:
571:
567:
563:
559:
555:
551:
547:
543:
539:
536:
535:
524:
521:
520:
518:
517:
516:amniotic fluid
513:
512:left ventricle
509:
505:
501:
497:
493:
489:
485:
481:
480:jejunal mucosa
477:
474:
473:
461:
460:
452:
441:
435:
434:
431:RNA expression
423:
422:
419:
418:
410:
406:
405:
397:
394:
389:
383:
382:
373:
366:
360:
356:
355:
350:
344:
343:
335:
334:
322:
321:
318:
317:
309:
305:
304:
296:
293:
288:
282:
281:
272:
265:
259:
255:
254:
247:
241:
240:
232:
231:
219:
218:
175:
171:
170:
162:
154:
153:
149:
148:
145:
144:
141:
140:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4354:
4343:
4340:
4338:
4335:
4334:
4332:
4317:
4314:
4312:
4309:
4307:
4304:
4303:
4301:
4299:
4293:
4287:
4284:
4282:
4278:
4274:
4271:
4269:
4266:
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4246:
4244:
4241:
4239:
4236:
4234:
4231:
4229:
4226:
4224:
4221:
4219:
4216:
4215:
4214:
4210:
4209:
4206:
4202:
4201:
4199:
4197:
4193:
4187:
4184:
4182:
4179:
4177:
4174:
4173:
4171:
4169:
4165:
4159:
4156:
4154:
4151:
4149:
4146:
4145:
4143:
4141:
4136:
4128:
4125:
4124:
4123:
4120:
4118:
4115:
4113:
4110:
4108:
4105:
4101:
4098:
4096:
4093:
4091:
4088:
4086:
4083:
4082:
4080:
4078:
4075:
4071:
4068:
4066:
4063:
4061:
4058:
4056:
4053:
4052:
4050:
4049:
4047:
4045:
4041:
4036:
4026:
4023:
4021:
4018:
4016:
4013:
4010:
4007:
4005:
4002:
4000:
3996:
3992:
3988:
3986:
3983:
3981:
3977:
3973:
3972:
3970:
3965:
3961:
3956:
3952:
3945:
3940:
3938:
3933:
3931:
3926:
3925:
3922:
3915:
3911:
3910:
3905:
3901:
3897:
3894:
3890:
3889:
3884:
3880:
3876:
3873:
3869:
3868:
3863:
3862:
3857:
3855:
3852:
3849:
3845:
3842:
3841:
3837:
3828:
3824:
3818:
3815:
3810:
3806:
3801:
3796:
3792:
3788:
3784:
3777:
3774:
3769:
3765:
3760:
3755:
3751:
3747:
3743:
3736:
3733:
3728:
3724:
3719:
3714:
3710:
3706:
3702:
3695:
3692:
3687:
3683:
3679:
3675:
3671:
3667:
3660:
3657:
3652:
3648:
3644:
3640:
3636:
3632:
3625:
3622:
3617:
3613:
3609:
3605:
3601:
3597:
3590:
3587:
3582:
3578:
3574:
3570:
3565:
3560:
3556:
3552:
3548:
3541:
3538:
3533:
3529:
3525:
3521:
3517:
3513:
3506:
3503:
3498:
3494:
3490:
3486:
3482:
3478:
3471:
3468:
3463:
3459:
3455:
3451:
3447:
3443:
3439:
3435:
3427:
3424:
3419:
3415:
3411:
3407:
3403:
3399:
3395:
3391:
3384:
3381:
3376:
3372:
3368:
3364:
3360:
3356:
3352:
3348:
3340:
3337:
3332:
3328:
3324:
3320:
3316:
3312:
3305:
3302:
3289:
3285:
3279:
3276:
3271:
3267:
3262:
3257:
3253:
3249:
3245:
3238:
3235:
3222:
3216:
3214:
3210:
3205:
3201:
3197:
3193:
3189:
3185:
3181:
3177:
3170:
3167:
3162:
3158:
3153:
3148:
3144:
3140:
3136:
3129:
3126:
3121:
3117:
3113:
3109:
3105:
3101:
3094:
3091:
3086:
3080:
3077:
3072:
3068:
3064:
3060:
3056:
3052:
3044:
3041:
3036:
3032:
3028:
3024:
3020:
3016:
3008:
3005:
3000:
2996:
2991:
2986:
2981:
2976:
2972:
2968:
2964:
2957:
2954:
2949:
2945:
2941:
2937:
2933:
2929:
2925:
2921:
2913:
2910:
2905:
2901:
2896:
2891:
2887:
2883:
2879:
2875:
2871:
2864:
2861:
2856:
2852:
2848:
2844:
2840:
2836:
2832:
2828:
2821:
2818:
2813:
2809:
2805:
2801:
2797:
2791:
2787:
2783:
2779:
2772:
2769:
2756:
2752:
2748:
2742:
2739:
2734:
2730:
2725:
2720:
2716:
2712:
2708:
2704:
2700:
2693:
2690:
2685:
2679:
2677:
2675:
2671:
2666:
2662:
2658:
2654:
2650:
2646:
2642:
2638:
2630:
2627:
2622:
2618:
2613:
2608:
2603:
2598:
2594:
2590:
2586:
2582:
2578:
2571:
2568:
2563:
2559:
2553:
2550:
2545:
2541:
2535:
2532:
2528:
2524:
2519:
2517:
2515:
2511:
2507:
2503:
2498:
2496:
2494:
2490:
2483:
2479:
2478:ApoA-1 Milano
2476:
2474:
2471:
2469:
2466:
2465:
2461:
2451:
2444:
2441:
2434:
2429:
2421:
2359:
2047:
2032:
2031:
2024:
2022:
2019:
2015:
2011:
2007:
2003:
1995:
1991:
1988:
1986:
1983:
1981:
1978:
1977:
1976:
1974:
1966:
1964:
1962:
1957:
1955:
1951:
1943:
1941:
1934:
1932:
1930:
1926:
1925:schizophrenia
1921:
1919:
1915:
1910:
1908:
1904:
1900:
1896:
1892:
1888:
1884:
1880:
1876:
1872:
1864:
1862:
1855:
1853:
1850:
1848:
1843:
1841:
1837:
1833:
1829:
1825:
1821:
1820:
1819:ApoA-I Milano
1815:
1813:
1809:
1805:
1801:
1797:
1789:
1784:
1782:
1780:
1772:
1770:
1768:
1764:
1759:
1757:
1752:
1750:
1746:
1742:
1738:
1734:
1729:
1725:
1723:
1719:
1717:
1713:
1705:
1703:
1701:
1697:
1693:
1692:chromosome 11
1689:
1682:
1680:
1678:
1674:
1670:
1667:
1663:
1659:
1656:
1644:
1639:
1635:
1631:
1628:
1624:
1617:
1615:
1612:
1608:
1604:
1600:
1597:
1593:
1589:
1582:
1580:
1574:
1570:
1567:
1561:
1559:
1555:
1549:
1545:
1541:
1537:
1533:
1529:
1525:
1522:
1518:
1511:
1509:
1503:
1499:
1496:
1490:
1488:
1484:
1480:
1476:
1470:
1466:
1463:
1461:RefSeq (mRNA)
1459:
1452:
1451:
1446:
1442:
1439:
1433:
1432:
1427:
1423:
1420:
1418:
1414:
1407:
1406:
1401:
1397:
1394:
1388:
1387:
1382:
1378:
1375:
1373:
1369:
1362:
1361:
1356:
1352:
1349:
1343:
1342:
1337:
1333:
1330:
1328:
1324:
1321:
1318:
1316:
1313:
1309:
1306:
1302:
1298:
1291:
1287:
1282:
1276:
1273:
1271:
1268:
1266:
1263:
1261:
1258:
1256:
1253:
1251:
1248:
1246:
1243:
1241:
1238:
1236:
1233:
1231:
1228:
1226:
1223:
1221:
1218:
1216:
1213:
1211:
1208:
1206:
1203:
1201:
1198:
1196:
1193:
1191:
1188:
1186:
1183:
1181:
1178:
1176:
1173:
1171:
1168:
1166:
1163:
1161:
1158:
1156:
1153:
1151:
1148:
1146:
1143:
1141:
1138:
1136:
1133:
1131:
1128:
1126:
1123:
1121:
1118:
1116:
1113:
1111:
1108:
1106:
1103:
1101:
1098:
1096:
1093:
1091:
1088:
1086:
1083:
1081:
1078:
1076:
1073:
1071:
1068:
1066:
1065:lipid storage
1063:
1061:
1058:
1056:
1053:
1051:
1048:
1046:
1043:
1041:
1038:
1036:
1033:
1031:
1028:
1026:
1023:
1021:
1018:
1016:
1013:
1011:
1008:
1006:
1003:
1001:
998:
996:
993:
991:
988:
986:
983:
981:
978:
976:
973:
971:
968:
966:
963:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
902:
900:
897:
896:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
776:
774:
771:
770:
764:
761:
759:
756:
754:
753:lipid binding
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
669:
666:
664:
661:
660:
658:
655:
654:
651:
650:Gene ontology
647:
643:
631:
626:
622:
615:
610:
607:
605:
601:
593:
588:
577:
573:
569:
565:
561:
557:
553:
549:
545:
541:
540:
537:
533:
528:
525:
515:
511:
507:
504:apex of heart
503:
499:
495:
491:
487:
483:
479:
478:
475:
471:
466:
463:
462:
459:
457:
453:
451:
450:
446:
445:
442:
440:
436:
432:
428:
424:
416:
411:
407:
403:
398:
388:
384:
377:
370:
364:
357:
349:
345:
341:
336:
332:
327:
323:
315:
310:
306:
302:
297:
287:
283:
276:
269:
263:
256:
252:
246:
242:
238:
233:
229:
224:
220:
216:
212:
208:
204:
200:
196:
192:
188:
184:
180:
172:
167:
160:
155:
150:
139:
137:
133:
129:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
30:
19:
4296:ATP-binding
4054:
3989:delivery of
3974:delivery of
3907:
3886:
3866:
3860:
3827:the original
3817:
3790:
3786:
3776:
3749:
3745:
3735:
3708:
3704:
3694:
3669:
3665:
3659:
3637:(1): 16–26.
3634:
3630:
3624:
3599:
3595:
3589:
3554:
3550:
3540:
3515:
3511:
3505:
3480:
3476:
3470:
3437:
3433:
3426:
3393:
3389:
3383:
3350:
3346:
3339:
3314:
3310:
3304:
3292:. Retrieved
3288:the original
3278:
3251:
3247:
3237:
3225:. Retrieved
3179:
3175:
3169:
3142:
3138:
3128:
3103:
3099:
3093:
3079:
3054:
3050:
3043:
3018:
3014:
3007:
2970:
2966:
2956:
2923:
2919:
2912:
2877:
2873:
2863:
2833:(1): 84–99.
2830:
2826:
2820:
2777:
2771:
2759:. Retrieved
2755:the original
2750:
2741:
2706:
2702:
2692:
2643:(1): 39–40.
2640:
2636:
2629:
2584:
2580:
2570:
2561:
2552:
2543:
2534:
2443:
2029:
2028:
2017:
2014:coexpression
1999:
1970:
1967:Interactions
1959:Exercise or
1958:
1953:
1947:
1938:
1922:
1911:
1906:
1895:chondrocytes
1878:
1871:polymorphism
1868:
1859:
1851:
1844:
1817:
1816:
1799:
1793:
1776:
1773:Applications
1767:nephelometry
1760:
1753:
1741:prostacyclin
1730:
1726:
1722:Chylomicrons
1720:
1709:
1699:
1687:
1686:
1665:
1657:
1654:
1653:
1576:
1551:
1540:NP_001304950
1536:NP_001304947
1532:NP_001304946
1505:
1487:NM_001318021
1483:NM_001318018
1479:NM_001318017
1472:
1448:
1429:
1403:
1384:
1358:
1339:
1319:
1314:
824:cell surface
492:right testis
454:
447:
312:116,837,622
299:116,835,751
174:External IDs
85:
29:
3980:Chylomicron
3964:Lipoprotein
3955:lipoprotein
1903:amyloidosis
1840:heterodimer
1804:cholesterol
1749:amyloidosis
1544:NP_000030.1
789:chylomicron
562:gallbladder
496:left testis
413:46,141,764
400:46,139,878
152:Identifiers
4331:Categories
3100:Metabolism
2529:, May 2017
2508:, May 2017
2484:References
1950:calcitriol
1927:patients'
458:(ortholog)
195:HomoloGene
2812:213180689
1918:endotoxin
1909:mutants.
1899:cartilage
1847:atheromas
1836:homodimer
1798:complex (
1779:nanodiscs
1683:Structure
1579:NP_033822
1528:NP_000030
1508:NM_009692
1475:NM_000039
1305:Orthologs
1100:transport
203:GeneCards
3768:11254757
3727:12084722
3686:12801612
3651:16236546
3616:18378026
3573:17938634
3532:15188057
3497:17075859
3462:30014992
3454:15584908
3418:42148248
3410:16130094
3375:23793589
3367:17654446
3331:17825930
3270:14600188
3204:75941726
3196:12642784
3161:15805548
3035:16023124
2999:31333463
2948:26567691
2940:18640459
2847:18079757
2804:32189309
2761:25 March
2733:23965338
2665:22613512
2525:–
2504:–
2462:See also
1973:interact
1875:promoter
1838:or as a
1832:cysteine
1808:atheroma
1706:Function
1658:(Apo-AI)
1627:Wikidata
1284:Sources:
554:duodenum
550:yolk sac
500:duodenum
4140:enzymes
3914:PDBe-KB
3904:UniProt
3893:PDBe-KB
3883:UniProt
3809:9469594
3581:5576909
3294:26 July
3227:26 July
3120:6785551
3071:9931341
2990:6616253
2904:3047170
2855:1989187
2724:4076475
2657:1972696
2621:6294659
2589:Bibcode
2527:Ensembl
2506:Ensembl
2039:[[File:
2018:E. coli
2002:APOA1BP
1891:Amyloid
1877:of the
1873:in the
1662:protein
1417:UniProt
1372:Ensembl
1311:Species
1290:QuickGO
799:nucleus
779:cytosol
546:jejunum
433:pattern
291:11q23.3
159:Aliases
4286:LRPAP1
4205:SCARB1
4011:sd LDL
4008:lb LDL
3951:Lipids
3909:Q00623
3888:P02647
3858:Human
3850:(MeSH)
3807:
3766:
3725:
3684:
3649:
3614:
3579:
3571:
3530:
3495:
3460:
3452:
3416:
3408:
3373:
3365:
3329:
3268:
3202:
3194:
3159:
3118:
3069:
3033:
2997:
2987:
2946:
2938:
2920:Lancet
2902:
2895:303586
2892:
2853:
2845:
2810:
2802:
2792:
2731:
2721:
2663:
2655:
2619:
2612:347233
2609:
1975:with:
1961:statin
1869:A G/A
1716:plasma
1613:search
1611:PubMed
1450:Q00623
1431:P02647
1327:Entrez
604:BioGPS
183:107680
4316:ABCG8
4311:ABCG5
4306:ABCA1
4279:LDL:
4273:LRP12
4268:LRP11
4263:LRP10
4248:LRP5L
4223:LRP1B
4211:IDL:
4203:HDL:
4081:APOC
4051:APOA
4015:Lp(a)
3867:APOA1
3861:APOA1
3577:S2CID
3458:S2CID
3414:S2CID
3371:S2CID
3200:S2CID
2944:S2CID
2851:S2CID
2808:S2CID
2661:S2CID
2351:]
1985:GPLD1
1980:ABCA1
1954:APOA1
1907:APOA1
1879:APOA1
1763:ELISA
1700:APOA1
1688:APOA1
1666:APOA1
1660:is a
1360:11806
1320:Mouse
1315:Human
1286:Amigo
566:ileum
508:gonad
456:Mouse
449:Human
396:Start
331:Mouse
295:Start
228:Human
207:APOA1
199:47900
191:88049
166:APOA1
35:APOA1
18:ApoA1
4281:LDLR
4258:LRP8
4253:LRP6
4243:LRP5
4238:LRP4
4233:LRP3
4228:LRP2
4218:LRP1
4186:PLTP
4181:MTTP
4176:CETP
4153:LIPC
4148:LCAT
4127:SAA1
4117:APOH
4112:APOE
4107:APOD
4077:APOB
3993:and
3985:VLDL
3902:for
3881:for
3805:PMID
3764:PMID
3723:PMID
3682:PMID
3647:PMID
3635:1737
3612:PMID
3569:PMID
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