227:
187:
260:. It is seen in women mostly over the age of 50 years. Metaplasia happens when there is an irritation to the breast (breast cyst). Apocrine-like cells form in a lining of developing microcysts, due to the pressure buildup within the lumen. The pressure build up is caused by secretions. This type of metaplasia represents an exception to the common rule of metaplasia increasing the risk for developing cancer in that apocrine metaplasia doesn't increase the possibility of developing breast cancer. Metaplastic apocrine cells belong to the category of
211:
199:
572:
Khandeparkar, Siddhi
Gaurish Sinai, Sanjay D. Deshmukh, and Pallavi D. Bhayekar. "A rare case of apocrine carcinoma of the breast: Cytopathological and immunohistopathological study." Journal of Cytology/Indian Academy of Cytologists 31.2 (2014):
323:
is a very rare form of female breast cancer. The rate of incidence varies from 0.5 to 4%. Cytologically, the cells of apocrine carcinoma are relatively large, granular, and it has a prominent
658:
610:
440:
651:
56:
644:
210:
176:
Apocrine secretion is less damaging to the gland than holocrine secretion (which destroys a cell) but more damaging than merocrine secretion (
312:
300:
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303:
tumors but differ from them in that they are completely localized, i.e. have not invaded nearby tissues or metastasized to distant tissues.
795:
186:
226:
49:
155:
775:
768:
761:
328:
583:
360:
381:
Mescher AL, "Chapter 4. Epithelial Tissue" (Chapter). Mescher AL: Junqueira's Basic
Histology: Text & Atlas, 12e:
42:
741:
734:
715:
257:
631:
1009:
692:
687:
682:
292:
809:
800:
422:
336:
169:, responsible for secreting breast milk. Apocrine glands are also found in the anogenital region and
455:
855:
147:
941:
1004:
968:
958:
555:
506:
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434:
402:
332:
545:
537:
496:
480:
143:
102:
198:
946:
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139:
382:
237:
of the breast with typical features, including apical snouts with eosinophilic granules.
979:
953:
900:
550:
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468:
296:
34:
998:
963:
895:
166:
921:
916:
324:
238:
725:
720:
396:
265:
541:
17:
814:
667:
291:(ACDIS) is a very rare breast carcinoma which is regarded as a variant of the
281:
Pure apocrine carcinoma of the breast § Apocrine ductal carcinoma in situ
249:
234:
230:
177:
72:
587:
492:
368:
867:
850:
484:
319:
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253:
159:
135:
87:
68:
559:
510:
406:
395:
Murphrey, Morgan B.; Safadi, Anthony O.; Vaidya, Tanvi (August 10, 2020).
268:, granular cytoplasm (from the Greek root onco-, which means mass, bulk).
151:
142:. In apocrine secretion, secretory cells accumulate material at their
975:
170:
636:
454:
Dr Ayush Goel and
Radswiki et al. Apocrine metaplasia of the breast.
611:"A[pcrome Breast Cancer - Johns Hopkins Kimmel Cancer Center"
456:
http://radiopaedia.org/articles/apocrine-metaplasia-of-the-breast
340:
640:
331:, it means that the cells of the patient cannot express the
114:
123:
108:
419:
Image by Mikael Häggström, MD. Reference for findings:
383:
http://www.accessmedicine.com/content.aspx?aID=6180489
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843:
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158:. The secretory cells therefore lose part of their
105:
469:"Non‐operative breast pathology: apocrine lesions"
327:cytoplasm. When apocrine carcinoma is tested as a
421:Carlos C. Diez Freire, M.D., Shahla Masood, M.D.
29:
361:"Apocrine | Meaning of Apocrine by Lexico"
256:. It is common in the breast in the context of
264:, which are a group characterized by abundant
27:Classification of secretion of exocrine glands
652:
295:breast tumors. ACDIS tumors have microscopic
50:
8:
524:Quinn CM, D'Arcy C, Wells C (January 2022).
439:: CS1 maint: multiple names: authors list (
216:Histology of apocrine cells, H&E stain.
840:
833:
785:
751:
705:
659:
645:
637:
467:Wells, C A; El‐Ayat, G A (December 2007).
165:An example of true apocrine glands is the
134:) is a term used to classify the mode of
82:– by membrane budding (loss of cytoplasm)
57:
43:
549:
500:
225:
352:
182:
432:
154:from the cells, forming extracellular
313:Pure apocrine carcinoma of the breast
301:pure apocrine carcinoma of the breast
7:
796:Pseudostratified columnar epithelium
150:or "snouts", and this material then
365:Lexico Dictionaries | English
25:
526:"Apocrine lesions of the breast"
445:Last author update: 28 May 2020.
248:is a reversible transformation (
209:
197:
185:
101:
776:Stratified columnar epithelium
769:Stratified cuboidal epithelium
762:Stratified squamous epithelium
1:
584:"Final Diagnosis -- Case 209"
473:Journal of Clinical Pathology
299:features that are similar to
162:in the process of secretion.
599:(accessed November 3, 2014)
1026:
742:Simple columnar epithelium
735:Simple cuboidal epithelium
716:Simple squamous epithelium
542:10.1007/s00428-021-03185-4
310:
286:Apocrine ductal carcinoma
278:
272:Apocrine ductal carcinoma
252:) of cells to an apocrine
401:. StatPearls Publishing.
398:Histology, Apocrine Gland
293:ductal carcinoma in situ
810:Transitional epithelium
615:www.hopkinsmedicine.org
485:10.1136/jcp.2006.040626
801:Respiratory epithelium
242:
90:– by membrane rupture
632:Diagram at uwa.edu.au
423:"Apocrine metaplasia"
337:progesterone receptor
229:
146:ends, often forming
246:Apocrine metaplasia
222:Apocrine metaplasia
942:Myoepithelial cell
609:Potter, Michelle.
427:Pathology Outlines
307:Apocrine carcinoma
258:fibrocystic change
243:
192:Apocrine secretion
992:
991:
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929:
825:
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479:(12): 1313–1320.
371:on July 26, 2020.
333:estrogen receptor
329:“triple negative"
233:showing apocrine
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93:
16:(Redirected from
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586:. Archived from
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464:
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367:. Archived from
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71:or eccrine – by
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30:
21:
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1024:
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1016:
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1010:Exocrine system
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947:Serous demilune
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530:Virchows Archiv
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354:
349:
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309:
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193:
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140:exocrine glands
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100:
63:
28:
23:
22:
18:Apocrine glands
15:
12:
11:
5:
1023:
1021:
1013:
1012:
1007:
997:
996:
990:
989:
986:
985:
983:
982:
973:
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971:
966:
961:
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949:
944:
938:
936:
932:
931:
928:
927:
925:
924:
919:
913:
911:
907:
906:
904:
903:
901:Alveolar gland
898:
892:
890:
886:
885:
883:
882:
881:
880:
875:
865:
860:
859:
858:
847:
845:
838:
831:
827:
826:
823:
822:
820:
819:
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803:
792:
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778:
772:
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731:
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626:External links
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536:(1): 177–189.
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311:Main article:
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297:histopathology
279:Main article:
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204:Apocrine gland
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167:mammary glands
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3:
2:
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969:Intercalated
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948:
945:
943:
940:
939:
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922:Mucous glands
920:
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917:Serous glands
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897:
896:Tubular gland
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590:on 2000-03-12
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239:H&E stain
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959:Intralobular
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592:. Retrieved
588:the original
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369:the original
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325:eosinophilic
317:
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273:
245:
244:
175:
164:
96:
95:
79:
33:
726:Mesothelium
721:Endothelium
266:acidophilic
999:Categories
935:Components
815:Urothelium
755:stratified
668:Epithelial
594:2014-11-03
347:References
343:receptor.
250:metaplasia
235:metaplasia
231:Micrograph
178:exocytosis
73:exocytosis
964:Striated
910:Secretion
878:Meibomian
873:Sebaceous
868:Holocrine
851:Merocrine
844:Mechanism
688:Cuboidal
683:Squamous
493:0021-9746
320:carcinoma
318:Apocrine
262:oncocytes
254:phenotype
160:cytoplasm
136:secretion
88:Holocrine
69:Merocrine
37:secretion
1005:Apocrine
863:Apocrine
693:Columnar
560:34537861
511:18042688
435:cite web
407:29489220
156:vesicles
152:buds off
97:Apocrine
80:Apocrine
35:Exocrine
856:Eccrine
551:8983539
502:2095572
288:in situ
274:in situ
171:axillae
976:Acinus
830:Glands
709:Simple
670:tissue
558:
548:
509:
499:
491:
405:
144:apical
954:Ducts
889:Shape
837:Types
789:Other
702:Types
676:Cells
339:, or
148:blebs
980:Lobe
556:PMID
507:PMID
489:ISSN
441:link
403:PMID
341:HER2
58:edit
51:talk
44:view
573:96.
546:PMC
538:doi
534:480
497:PMC
481:doi
180:).
138:of
1001::
613:.
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532:.
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241:.
130:/
127:n
124:ɪ
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118:k
115:ə
112:p
109:æ
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103:/
99:(
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