374:
351:
248:
273:
1857:(MOM). A hydrophobic groove formed along the C-terminal of α2 to the N-terminal of α5, and some residues from α8, binds the BH3 domain of other BAX or BCL-2 proteins in its active form. In the protein's inactive form, the groove binds its transmembrane domain, transitioning it from a membrane-bound to a cytosolic protein. A smaller hydrophobic groove formed by the α1 and α6 helices is located on the opposite side of the protein from the major groove, and may serve as a BAX activation site.
1979:
632:
625:
1813:. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of
3649:
1910:. This defines a direct role for BAX in mitochondrial outer membrane permeabilization. BAX activation is stimulated by various abiotic factors, including heat, hydrogen peroxide, low or high pH, and mitochondrial membrane remodeling. In addition, it can become activated by binding BCL-2, as well as non-BCL-2 proteins such as p53 and Bif-1. Conversely, BAX can become inactivated by interacting with VDAC2, Pin1, and IBRDC2.
380:
279:
33:
2787:
McArthur K, Whitehead LW, Heddleston JM, Li L, Padman BS, Oorschot V, Geoghegan ND, Chappaz S, Davidson S, San Chin H, Lane RM, Dramicanin M, Saunders TL, Sugiana C, Lessene R, Osellame LD, Chew TL, Dewson G, Lazarou M, Ramm G, Lessene G, Ryan MT, Rogers KL, van Delft MF, Kile BT (22 February 2018).
59:
1852:
entitled the Bcl-2 homology (BH) domains (named BH1, BH2, BH3 and BH4), and can form hetero- or homodimers. These domains are composed of nine α-helices, with a hydrophobic α-helix core surrounded by amphipathic helices and a transmembrane C-terminal α-helix anchored to the
2900:
Selvakumaran M, Lin HK, Miyashita T, Wang HG, Krajewski S, Reed JC, Hoffman B, Liebermann D (June 1994). "Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways".
1954:
as a primary transcription factor. However, p53 also has a transcription-independent role in apoptosis. In particular, p53 interacts with BAX, promoting its activation as well as its insertion into the mitochondrial membrane.
3316:
Marzo I, Brenner C, Zamzami N, Jürgensmeier JM, Susin SA, Vieira HL, Prévost MC, Xie Z, Matsuyama S, Reed JC, Kroemer G (1998). "Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis".
1962:, a BH3 mimetic, hold promise as anticancer treatments by inducing apoptosis in cancer cells. For instance, binding of HA-BAD to BCL-xL and concomitant disruption of BAX:BCL-xL interaction was found to partly reverse
2873:
Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, Hoffman B, Reed JC (June 1994). "Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo".
3107:
Komatsu K, Miyashita T, Hang H, Hopkins KM, Zheng W, Cuddeback S, Yamada M, Lieberman HB, Wang HG (2000). "Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosis".
2711:
Shi Y, Chen J, Weng C, Chen R, Zheng Y, Chen Q, Tang H (June 2003). "Identification of the protein–protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins".
3689:
2438:
1899:
1887:, Bax undergoes a conformational shift. Upon induction of apoptosis, BAX becomes organelle membrane-associated, and in particular, mitochondrial membrane associated.
387:
286:
1970:
cells. Meanwhile, excessive apoptosis in such conditions as ischemia reperfusion injury and amyotrophic lateral sclerosis may benefit from drug inhibitors of BAX.
4026:
3933:
3754:
2265:
Oltvai ZN, Milliman CL, Korsmeyer SJ (August 1993). "Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death".
2834:"Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells"
1460:
2624:
Pierrat B, Simonen M, Cueto M, Mestan J, Ferrigno P, Heim J (January 2001). "SH3GLB, a new endophilin-related protein family featuring an SH3 domain".
209:
56:
3682:
1441:
1906:
and other pro-apoptotic factors from the mitochondria, often referred to as mitochondrial outer membrane permeabilization, leading to activation of
1938:. Wild-type p53 has been demonstrated to upregulate the transcription of a chimeric reporter plasmid utilizing the consensus promoter sequence of
2123:
2748:"Deficiency in apoptotic effectors Bax and Bak reveals an autophagic cell death pathway initiated by photodamage to the endoplasmic reticulum"
4091:
3628:
2203:
3963:
3795:
3675:
2185:
2097:
3648:
3150:
Zhang H, Nimmer P, Rosenberg SH, Ng SC, Joseph M (2002). "Development of a high-throughput fluorescence polarization assay for Bcl-x(L)".
2980:
Strobel T, Tai YT, Korsmeyer S, Cannistra SA (November 1998). "BAD partly reverses paclitaxel resistance in human ovarian cancer cells".
373:
3843:
1895:
1728:
3546:
1735:
350:
3923:
3918:
3766:
1991:
3848:
2172:
2151:
1891:
3187:"Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway"
4101:
2442:
272:
247:
3277:"Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax"
2168:
3552:
2147:
189:
3900:
3837:
3236:"Structural basis of BFL-1 for its interaction with BAX and its anti-apoptotic action in mammalian and yeast cells"
386:
285:
4066:
3621:
1934:
that, when activated as part of the cell's response to stress, regulates many downstream target genes, including
379:
278:
4000:
1890:
BAX is believed to interact with, and induce the opening of the mitochondrial voltage-dependent anion channel,
1505:
197:
3910:
3736:
2010:
1486:
1106:
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
4034:
3185:
Gillissen B, Essmann F, Graupner V, Stärck L, Radetzki S, Dörken B, Schulze-Osthoff K, Daniel PT (2003).
3892:
3718:
1923:
261:
2391:"Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis"
3614:
3326:
2526:
2328:
1931:
1690:
3060:"Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3"
2466:"Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis"
2221:
3701:
3558:
1664:
1660:
1656:
1652:
1585:
1581:
1577:
1573:
176:
4096:
3132:
3089:
3005:
2959:
2290:
2004:
1849:
221:
1711:
1686:
1682:
1678:
1668:
1632:
1611:
1607:
1603:
1599:
1589:
936:
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
1978:
4106:
3586:
3565:
3525:
3473:
3424:
3383:
3342:
3298:
3257:
3216:
3167:
3124:
3081:
3040:
2997:
2951:
2910:
2882:
2855:
2811:
2769:
2728:
2690:
2641:
2603:
2554:
2495:
2420:
2356:
2282:
169:
49:
1351:
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
3515:
3507:
3463:
3455:
3414:
3373:
3334:
3288:
3275:
Cuddeback SM, Yamaguchi H, Komatsu K, Miyashita T, Yamada M, Wu C, Singh S, Wang HG (2001).
3247:
3206:
3198:
3159:
3116:
3071:
3032:
2989:
2941:
2845:
2801:
2759:
2720:
2680:
2672:
2633:
2593:
2585:
2544:
2534:
2485:
2477:
2410:
2402:
2346:
2336:
2274:
1845:
901:
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
466:
397:
341:
296:
631:
624:
2790:"BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis"
1001:
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
441:
2315:
Sedlak TW, Oltvai ZN, Yang E, Wang K, Boise LH, Thompson CB, Korsmeyer SJ (August 1995).
217:
3330:
2530:
2332:
1930:, and BAX has been shown to be involved in p53-mediated apoptosis. The p53 protein is a
1171:
positive regulation of mitochondrial membrane permeability involved in apoptotic process
3520:
3495:
3468:
3443:
3442:
Hoppins S, Edlich F, Cleland MM, Banerjee S, McCaffery JM, Youle RJ, Nunnari J (2011).
2685:
2660:
2598:
2573:
2490:
2465:
2415:
2390:
1967:
1884:
1841:
3211:
3186:
3163:
3076:
3059:
2724:
1375:
1370:
1365:
1360:
1355:
1350:
1345:
1340:
1335:
1330:
1325:
1320:
1315:
1310:
1305:
1300:
1295:
1290:
1285:
1280:
1275:
1270:
1265:
1260:
1255:
1250:
1245:
1240:
1235:
1230:
1225:
1220:
1215:
1210:
1205:
1200:
1195:
1190:
1185:
1180:
1175:
1170:
1165:
1160:
1155:
1150:
1145:
1140:
1135:
1130:
1125:
1120:
1115:
1110:
1105:
1100:
1095:
1090:
1085:
1080:
1075:
1070:
1065:
1060:
1055:
1050:
1045:
1040:
1035:
1030:
1025:
1020:
1015:
1010:
1005:
1000:
995:
990:
985:
980:
975:
970:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
713:
708:
703:
698:
693:
688:
683:
678:
673:
4085:
3985:
3595:
3574:
3444:"The Soluble Form of Bax Regulates Mitochondrial Fusion via MFN2 Homotypic Complexes"
3058:
Lin B, Kolluri SK, Lin F, Liu W, Han YH, Cao X, Dawson MI, Reed JC, Zhang XK (2004).
2946:
2929:
2549:
2514:
2351:
2316:
2278:
2118:
1854:
1336:
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
660:
3136:
3093:
3009:
2963:
2294:
3823:
3802:
3744:
2108:
1903:
1814:
1810:
459:
238:
3338:
2930:"Tumor suppressor p53 is a direct transcriptional activator of the human bax gene"
2574:"Conformation of the Bax C-terminus regulates subcellular location and cell death"
201:
3459:
3401:
Nomura M, Shimizu S, Sugiyama T, Narita M, Ito T, Matsuda H, Tsujimoto Y (2003).
1286:
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
911:
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
225:
4044:
2208:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2190:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2069:
2063:
1021:
regulation of cysteine-type endopeptidase activity involved in apoptotic process
961:
activation of cysteine-type endopeptidase activity involved in apoptotic process
3036:
2481:
886:
regulation of mitochondrial membrane permeability involved in apoptotic process
542:
32:
3726:
3667:
2589:
2087:
1963:
358:
255:
205:
3990:
3252:
3235:
1136:
positive regulation of apoptotic process involved in mammary gland involution
3958:
3953:
3883:
3812:
3807:
3790:
3709:
3698:
2806:
2789:
2659:
Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, Youle RJ (December 1997).
2341:
2317:"Multiple Bcl-2 family members demonstrate selective dimerizations with Bax"
2082:
1983:
1860:
1834:
1405:
602:
480:
425:
412:
324:
311:
213:
3529:
3511:
3477:
3428:
3419:
3403:"14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax"
3402:
3387:
3302:
3293:
3276:
3261:
3234:
Zhang H, Cowan-Jacob SW, Simonen M, Greenhalf W, Heim J, Meyhack B (2000).
3220:
3202:
3171:
3128:
3085:
3044:
2993:
2859:
2850:
2833:
2815:
2773:
2732:
2676:
2645:
2637:
2607:
2539:
2424:
180:, BCL2L4, BCL2 associated X protein, BCL2 associated X, apoptosis regulator
3346:
3001:
2955:
2914:
2886:
2694:
2558:
2499:
2360:
2286:
1902:
in the MOM (mitochondrial outer membrane). This results in the release of
1894:. Alternatively, growing evidence also suggests that activated BAX and/or
1775:
1770:
4049:
4005:
2515:"Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis"
2406:
2103:
1907:
1759:
1554:
1535:
1531:
3378:
3361:
2246:
3600:
3590:
3579:
3569:
2021:
2015:
1959:
1880:
1868:
1795:
1517:
1472:
3362:"TCTP protects from apoptotic cell death by antagonizing bax function"
2764:
2747:
1246:
establishment or maintenance of transmembrane electrochemical gradient
1241:
positive regulation of endoplasmic reticulum unfolded protein response
1211:
negative regulation of endoplasmic reticulum calcium ion concentration
1131:
positive regulation of release of sequestered calcium ion into cytosol
146:
142:
138:
134:
130:
126:
122:
118:
114:
110:
106:
102:
98:
94:
90:
86:
82:
78:
3995:
3980:
3865:
1743:
1427:
1844:. Bcl-2 family members share one or more of the four characteristic
2661:"Movement of Bax from the cytosol to mitochondria during apoptosis"
1817:. The expression of this gene is regulated by the tumor suppressor
4059:
4054:
3970:
3941:
3860:
3120:
2092:
2039:
2027:
1998:
1977:
1838:
1390:
1386:
4039:
3975:
3948:
3785:
3778:
3773:
3496:"Bioactive lipids and the control of Bax pro-apoptotic activity"
3023:
Hoetelmans RW (2004). "Nuclear partners of Bcl-2: Bax and PML".
2113:
2057:
2033:
1879:
In healthy mammalian cells, the majority of BAX is found in the
1802:
1321:
extrinsic apoptotic signaling pathway via death domain receptors
1201:
positive regulation of release of cytochrome c from mitochondria
193:
3671:
3610:
1356:
intrinsic apoptotic signaling pathway in response to DNA damage
3606:
2746:
Buytaert E, Callewaert G, Vandenheede JR, Agostinis P (2006).
1943:
1927:
1818:
916:
positive regulation of IRE1-mediated unfolded protein response
640:
1821:
and has been shown to be involved in P53-mediated apoptosis.
3585:
Overview of all the structural information available in the
3564:
Overview of all the structural information available in the
1066:
positive regulation of intrinsic apoptotic signaling pathway
1221:
apoptotic process involved in embryonic digit morphogenesis
1036:
intrinsic apoptotic signaling pathway by p53 class mediator
1361:
extrinsic apoptotic signaling pathway in absence of ligand
3494:
Mignard V, Lalier L, Paris F, Vallette FM (29 May 2014).
1266:
regulation of mammary gland epithelial cell proliferation
1236:
mitochondrial fragmentation involved in apoptotic process
846:
positive regulation of calcium ion transport into cytosol
1366:
transcription initiation from RNA polymerase II promoter
931:
apoptotic process involved in blood vessel morphogenesis
449:
1982:
Overview of signal transduction pathways involved with
1376:
negative regulation of mitochondrial membrane potential
1306:
negative regulation of peptidyl-serine phosphorylation
2572:
Nechushtan A, Smith CL, Hsu YT, Youle RJ (May 1999).
2464:
Gross A, Jockel J, Wei MC, Korsmeyer SJ (July 1998).
614:
966:
negative regulation of cell population proliferation
4025:
4018:
3932:
3909:
3891:
3882:
3821:
3753:
3735:
3717:
3708:
3657:: SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX
2439:"OrthoMaM phylogenetic marker: BAX coding sequence"
1704:
1651:
1625:
1572:
2164:
2162:
2160:
2143:
2141:
2139:
1231:positive regulation of apoptotic DNA fragmentation
1006:negative regulation of apoptotic signaling pathway
760:mitochondrial permeability transition pore complex
1156:positive regulation of developmental pigmentation
1101:regulation of protein heterodimerization activity
396:
295:
2832:Weng C, Li Y, Xu D, Shi Y, Tang H (March 2005).
2389:Westphal D, Kluck RM, Dewson G (February 2014).
3489:
3487:
2827:
2825:
2706:
2704:
2619:
2617:
1216:regulation of protein homodimerization activity
1151:development of secondary sexual characteristics
1096:positive regulation of B cell apoptotic process
1061:negative regulation of fibroblast proliferation
926:positive regulation of neuron apoptotic process
831:negative regulation of neuron apoptotic process
2975:
2973:
2384:
2382:
2380:
2378:
2376:
2374:
2372:
2370:
2169:GRCm38: Ensembl release 89: ENSMUSG00000003873
1871:for which complete genome data are available.
1316:positive regulation of protein oligomerization
1281:regulation of mitochondrial membrane potential
1196:homeostasis of number of cells within a tissue
3683:
3622:
2260:
2258:
2256:
1990:Bcl-2-associated X protein has been shown to
1026:endoplasmic reticulum calcium ion homeostasis
8:
1261:post-embryonic camera-type eye morphogenesis
2310:
2308:
2306:
2304:
2148:GRCh38: Ensembl release 89: ENSG00000087088
1206:B cell receptor apoptotic signaling pathway
986:release of matrix enzymes from mitochondria
4022:
3888:
3759:
3714:
3690:
3676:
3668:
3629:
3615:
3607:
2513:Hsu YT, Wolter KG, Youle RJ (April 1997).
1648:
1569:
1401:
656:
437:
336:
233:
67:
3519:
3467:
3418:
3377:
3292:
3251:
3210:
3075:
2945:
2849:
2805:
2763:
2684:
2597:
2548:
2538:
2489:
2414:
2350:
2340:
1326:release of cytochrome c from mitochondria
2247:"Entrez Gene: BCL2-associated X protein"
1311:positive regulation of apoptotic process
906:odontogenesis of dentin-containing tooth
896:cellular response to DNA damage stimulus
3644:
3599:(Mouse Apoptosis regulator BAX) at the
3578:(Human Apoptosis regulator BAX) at the
2135:
1191:ectopic germ cell programmed cell death
18:Mammalian protein found in Homo sapiens
2124:p53 upregulated modulator of apoptosis
1946:. Thus it is likely that p53 promotes
1016:regulation of neuron apoptotic process
971:cellular response to organic substance
891:negative regulation of protein binding
22:
3360:Susini L, et al. (August 2008).
2928:Miyashita T, Reed JC (January 1995).
1341:intrinsic apoptotic signaling pathway
1161:retina development in camera-type eye
991:extrinsic apoptotic signaling pathway
401:
362:
357:
300:
259:
254:
7:
2098:BH3 interacting domain death agonist
1883:, but upon initiation of apoptotic
851:glycosphingolipid metabolic process
699:protein heterodimerization activity
3844:Bcl-2 homologous antagonist killer
1942:approximately 50-fold over mutant
1867:gene have been identified in most
1833:gene was the first identified pro-
1701:
1622:
1545:
1522:
1496:
1477:
1451:
1432:
1301:regulation of nitrogen utilization
1271:retinal cell programmed cell death
795:intracellular anatomical structure
619:
537:
475:
454:
14:
1958:Drugs that activate BAX, such as
1798:that in humans is encoded by the
674:protein homodimerization activity
3924:Tumor necrosis factor receptor 2
3919:Tumor necrosis factor receptor 1
3767:Death-inducing signaling complex
3647:
2395:Cell Death & Differentiation
976:B cell homeostatic proliferation
876:T cell homeostatic proliferation
630:
623:
385:
378:
372:
349:
284:
277:
271:
246:
31:
3849:Bcl-2-associated death promoter
1346:regulation of apoptotic process
1296:protein complex oligomerization
1291:apoptotic mitochondrial changes
1251:homeostasis of number of cells
836:response to ionizing radiation
800:endoplasmic reticulum membrane
790:integral component of membrane
641:More reference expression data
603:More reference expression data
1:
3339:10.1126/science.281.5385.2027
3164:10.1016/S0003-2697(02)00028-3
3077:10.1016/S0092-8674(04)00162-X
2725:10.1016/S0006-291X(03)00871-4
2713:Biochem. Biophys. Res. Commun
951:cell population proliferation
370:
269:
4092:Genes on human chromosome 19
3460:10.1016/j.molcel.2010.11.030
2947:10.1016/0092-8674(95)90412-3
2519:Proc. Natl. Acad. Sci. U.S.A
2321:Proc. Natl. Acad. Sci. U.S.A
2279:10.1016/0092-8674(93)90509-O
1855:mitochondrial outer membrane
1181:ovarian follicle development
810:mitochondrial outer membrane
745:Bcl-2 family protein complex
3901:Tumor necrosis factor alpha
1176:cerebral cortex development
1071:response to toxic substance
1056:response to gamma radiation
1051:protein homooligomerization
956:mitochondrion morphogenesis
946:apoptotic signaling pathway
871:thymocyte apoptotic process
495:stromal cell of endometrium
4123:
3557:gene details page in the
3037:10.1089/104454904323145236
1141:nervous system development
881:post-embryonic development
866:Sertoli cell proliferation
491:mucosa of transverse colon
4067:Apoptosis-inducing factor
3762:
3642:
2204:"Mouse PubMed Reference:"
2186:"Human PubMed Reference:"
1898:form an oligomeric pore,
1774:
1769:
1765:
1758:
1742:
1723:
1708:
1675:
1644:
1629:
1596:
1565:
1552:
1548:
1529:
1525:
1516:
1503:
1499:
1484:
1480:
1471:
1458:
1454:
1439:
1435:
1426:
1411:
1404:
1400:
1384:
1371:Unfolded Protein Response
1146:spermatid differentiation
1076:B cell negative selection
704:identical protein binding
659:
655:
638:
622:
613:
600:
549:
540:
487:
478:
448:
440:
436:
419:
406:
369:
348:
339:
335:
318:
305:
268:
245:
236:
232:
187:
184:
174:
167:
162:
75:
70:
53:
48:
43:
39:
30:
25:
3500:Cell Death & Disease
3253:10.1074/jbc.275.15.11092
2482:10.1093/emboj/17.14.3878
1729:Chr 19: 48.95 – 48.96 Mb
1276:regulation of cell cycle
1086:neuron apoptotic process
1041:hypothalamus development
1011:myeloid cell homeostasis
856:B cell apoptotic process
2807:10.1126/science.aao6047
2590:10.1093/emboj/18.9.2330
2342:10.1073/pnas.92.17.7834
1788:Apoptosis regulator BAX
1736:Chr 7: 45.11 – 45.12 Mb
1166:response to axon injury
1111:cellular response to UV
921:blood vessel remodeling
861:response to salt stress
765:mitochondrial membranes
519:upper lobe of left lung
3512:10.1038/cddis.2014.226
3420:10.1074/jbc.M207880200
3294:10.1074/jbc.M101527200
2994:10.1038/sj.onc.1202180
2851:10.1074/jbc.M412819200
2677:10.1083/jcb.139.5.1281
2638:10.1006/geno.2000.6378
2540:10.1073/pnas.94.8.3668
1987:
1922:is upregulated by the
1091:male gonad development
4102:Programmed cell death
1981:
1914:Clinical significance
1226:leukocyte homeostasis
841:germ cell development
780:extracellular exosome
775:endoplasmic reticulum
714:Hsp70 protein binding
577:stroma of bone marrow
262:Chromosome 19 (human)
3551:genome location and
3203:10.1093/emboj/cdg343
2445:on 24 September 2015
2407:10.1038/cdd.2013.139
1966:resistance in human
1950:apoptotic faculties
1932:transcription factor
1792:bcl-2-like protein 4
1081:mitochondrial fusion
1031:response to wounding
403:7 B3|7 29.32 cM
364:Chromosome 7 (mouse)
71:List of PDB id codes
44:Available structures
3559:UCSC Genome Browser
3379:10.1038/cdd.2008.18
3331:1998Sci...281.2027M
2531:1997PNAS...94.3668H
2333:1995PNAS...92.7834S
1809:is a member of the
1116:sex differentiation
585:ganglionic eminence
2800:(6378): eaao6047.
1988:
1918:The expression of
1506:ENSMUSG00000003873
1256:vagina development
1126:B cell homeostasis
996:kidney development
981:limb morphogenesis
824:Biological process
723:Cellular component
689:BH3 domain binding
667:Molecular function
4079:
4078:
4075:
4074:
4014:
4013:
3878:
3877:
3874:
3873:
3702:signaling pathway
3665:
3664:
3366:Cell Death Differ
3325:(5385): 2027–31.
2844:(11): 10491–500.
2765:10.4161/auto.2730
1811:Bcl-2 gene family
1785:
1784:
1781:
1780:
1754:
1753:
1719:
1718:
1698:
1697:
1640:
1639:
1619:
1618:
1561:
1560:
1542:
1541:
1512:
1511:
1493:
1492:
1467:
1466:
1448:
1447:
1396:
1395:
1331:apoptotic process
694:chaperone binding
651:
650:
647:
646:
609:
608:
596:
595:
534:
533:
432:
431:
331:
330:
158:
157:
154:
153:
54:Ortholog search:
4114:
4023:
3889:
3760:
3715:
3692:
3685:
3678:
3669:
3651:
3631:
3624:
3617:
3608:
3534:
3533:
3523:
3491:
3482:
3481:
3471:
3439:
3433:
3432:
3422:
3398:
3392:
3391:
3381:
3357:
3351:
3350:
3313:
3307:
3306:
3296:
3287:(23): 20559–65.
3272:
3266:
3265:
3255:
3231:
3225:
3224:
3214:
3182:
3176:
3175:
3147:
3141:
3140:
3104:
3098:
3097:
3079:
3055:
3049:
3048:
3020:
3014:
3013:
2977:
2968:
2967:
2949:
2925:
2919:
2918:
2897:
2891:
2890:
2870:
2864:
2863:
2853:
2829:
2820:
2819:
2809:
2784:
2778:
2777:
2767:
2743:
2737:
2736:
2708:
2699:
2698:
2688:
2656:
2650:
2649:
2621:
2612:
2611:
2601:
2569:
2563:
2562:
2552:
2542:
2510:
2504:
2503:
2493:
2461:
2455:
2454:
2452:
2450:
2441:. Archived from
2435:
2429:
2428:
2418:
2386:
2365:
2364:
2354:
2344:
2312:
2299:
2298:
2262:
2251:
2250:
2243:
2237:
2236:
2234:
2232:
2218:
2212:
2211:
2200:
2194:
2193:
2182:
2176:
2166:
2155:
2145:
1924:tumor suppressor
1790:, also known as
1767:
1766:
1738:
1731:
1714:
1702:
1693:
1649:
1645:RefSeq (protein)
1635:
1623:
1614:
1570:
1546:
1523:
1497:
1478:
1452:
1433:
1402:
1121:neuron migration
735:nuclear envelope
679:channel activity
657:
643:
634:
627:
620:
605:
569:ventricular zone
545:
543:Top expressed in
538:
483:
481:Top expressed in
476:
455:
438:
428:
415:
404:
389:
382:
376:
365:
353:
337:
327:
314:
303:
288:
281:
275:
264:
250:
234:
228:
179:
172:
149:
68:
62:
41:
40:
35:
23:
4122:
4121:
4117:
4116:
4115:
4113:
4112:
4111:
4082:
4081:
4080:
4071:
4010:
3928:
3905:
3870:
3856:Anti-apoptotic:
3817:
3749:
3731:
3704:
3696:
3666:
3661:
3658:
3652:
3638:
3635:
3542:
3537:
3493:
3492:
3485:
3441:
3440:
3436:
3400:
3399:
3395:
3359:
3358:
3354:
3315:
3314:
3310:
3274:
3273:
3269:
3246:(15): 11092–9.
3233:
3232:
3228:
3197:(14): 3580–90.
3184:
3183:
3179:
3149:
3148:
3144:
3106:
3105:
3101:
3057:
3056:
3052:
3022:
3021:
3017:
2988:(19): 2419–27.
2979:
2978:
2971:
2927:
2926:
2922:
2899:
2898:
2894:
2881:(6): 1799–805.
2872:
2871:
2867:
2831:
2830:
2823:
2786:
2785:
2781:
2745:
2744:
2740:
2710:
2709:
2702:
2658:
2657:
2653:
2623:
2622:
2615:
2571:
2570:
2566:
2512:
2511:
2507:
2476:(14): 3878–85.
2463:
2462:
2458:
2448:
2446:
2437:
2436:
2432:
2388:
2387:
2368:
2314:
2313:
2302:
2264:
2263:
2254:
2245:
2244:
2240:
2230:
2228:
2226:www.uniprot.org
2220:
2219:
2215:
2202:
2201:
2197:
2184:
2183:
2179:
2167:
2158:
2146:
2137:
2133:
2079:
1976:
1916:
1877:
1827:
1776:View/Edit Mouse
1771:View/Edit Human
1734:
1727:
1724:Location (UCSC)
1710:
1689:
1685:
1681:
1677:
1671:
1667:
1663:
1659:
1655:
1631:
1610:
1606:
1602:
1598:
1592:
1588:
1584:
1580:
1576:
1534:
1487:ENSG00000087088
1380:
941:spermatogenesis
819:
718:
684:protein binding
639:
629:
628:
601:
592:
587:
583:
579:
575:
571:
567:
563:
559:
555:
541:
530:
527:ascending aorta
525:
521:
517:
513:
509:
505:
501:
497:
493:
479:
423:
410:
402:
392:
391:
390:
383:
363:
340:Gene location (
322:
309:
301:
291:
290:
289:
282:
260:
237:Gene location (
226:BAX - orthologs
188:
175:
168:
77:
55:
19:
12:
11:
5:
4120:
4118:
4110:
4109:
4104:
4099:
4094:
4084:
4083:
4077:
4076:
4073:
4072:
4070:
4069:
4063:
4062:
4057:
4052:
4047:
4042:
4037:
4031:
4029:
4020:
4016:
4015:
4012:
4011:
4009:
4008:
4003:
3998:
3993:
3988:
3983:
3978:
3973:
3967:
3966:
3961:
3956:
3951:
3945:
3944:
3938:
3936:
3930:
3929:
3927:
3926:
3921:
3915:
3913:
3907:
3906:
3904:
3903:
3897:
3895:
3886:
3880:
3879:
3876:
3875:
3872:
3871:
3869:
3868:
3863:
3858:
3852:
3851:
3846:
3840:
3835:
3833:Pro-apoptotic:
3829:
3827:
3819:
3818:
3816:
3815:
3810:
3805:
3799:
3798:
3793:
3788:
3782:
3781:
3776:
3770:
3769:
3763:
3757:
3751:
3750:
3748:
3747:
3741:
3739:
3733:
3732:
3730:
3729:
3723:
3721:
3712:
3706:
3705:
3697:
3695:
3694:
3687:
3680:
3672:
3663:
3662:
3660:
3659:
3653:
3646:
3643:
3640:
3639:
3636:
3634:
3633:
3626:
3619:
3611:
3605:
3604:
3583:
3562:
3541:
3540:External links
3538:
3536:
3535:
3483:
3454:(2): 150–160.
3448:Molecular Cell
3434:
3413:(3): 2058–65.
3393:
3372:(8): 1211–20.
3352:
3308:
3267:
3226:
3177:
3142:
3109:Nat. Cell Biol
3099:
3050:
3015:
2969:
2920:
2892:
2865:
2821:
2779:
2738:
2700:
2671:(5): 1281–92.
2651:
2613:
2584:(9): 2330–41.
2564:
2525:(8): 3668–72.
2505:
2456:
2430:
2401:(2): 196–205.
2366:
2327:(17): 7834–8.
2300:
2252:
2238:
2213:
2195:
2177:
2156:
2134:
2132:
2129:
2128:
2127:
2121:
2116:
2111:
2106:
2101:
2095:
2090:
2085:
2078:
2075:
2074:
2073:
2067:
2061:
2055:
2052:
2049:
2046:
2043:
2037:
2031:
2025:
2019:
2013:
2008:
2002:
1975:
1972:
1968:ovarian cancer
1915:
1912:
1876:
1873:
1842:protein family
1837:member of the
1826:
1823:
1783:
1782:
1779:
1778:
1773:
1763:
1762:
1756:
1755:
1752:
1751:
1749:
1747:
1740:
1739:
1732:
1725:
1721:
1720:
1717:
1716:
1706:
1705:
1699:
1696:
1695:
1691:NP_001278358.1
1673:
1672:
1646:
1642:
1641:
1638:
1637:
1627:
1626:
1620:
1617:
1616:
1594:
1593:
1567:
1563:
1562:
1559:
1558:
1550:
1549:
1543:
1540:
1539:
1527:
1526:
1520:
1514:
1513:
1510:
1509:
1501:
1500:
1494:
1491:
1490:
1482:
1481:
1475:
1469:
1468:
1465:
1464:
1456:
1455:
1449:
1446:
1445:
1437:
1436:
1430:
1424:
1423:
1418:
1413:
1409:
1408:
1398:
1397:
1394:
1393:
1382:
1381:
1379:
1378:
1373:
1368:
1363:
1358:
1353:
1348:
1343:
1338:
1333:
1328:
1323:
1318:
1313:
1308:
1303:
1298:
1293:
1288:
1283:
1278:
1273:
1268:
1263:
1258:
1253:
1248:
1243:
1238:
1233:
1228:
1223:
1218:
1213:
1208:
1203:
1198:
1193:
1188:
1183:
1178:
1173:
1168:
1163:
1158:
1153:
1148:
1143:
1138:
1133:
1128:
1123:
1118:
1113:
1108:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1038:
1033:
1028:
1023:
1018:
1013:
1008:
1003:
998:
993:
988:
983:
978:
973:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
827:
825:
821:
820:
818:
817:
815:cell periphery
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
726:
724:
720:
719:
717:
716:
711:
706:
701:
696:
691:
686:
681:
676:
670:
668:
664:
663:
653:
652:
649:
648:
645:
644:
636:
635:
617:
611:
610:
607:
606:
598:
597:
594:
593:
591:
590:
586:
582:
578:
574:
570:
566:
562:
558:
554:
550:
547:
546:
535:
532:
531:
529:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
488:
485:
484:
472:
471:
463:
452:
446:
445:
442:RNA expression
434:
433:
430:
429:
421:
417:
416:
408:
405:
400:
394:
393:
384:
377:
371:
367:
366:
361:
355:
354:
346:
345:
333:
332:
329:
328:
320:
316:
315:
307:
304:
299:
293:
292:
283:
276:
270:
266:
265:
258:
252:
251:
243:
242:
230:
229:
186:
182:
181:
173:
165:
164:
160:
159:
156:
155:
152:
151:
73:
72:
64:
63:
52:
46:
45:
37:
36:
28:
27:
17:
13:
10:
9:
6:
4:
3:
2:
4119:
4108:
4105:
4103:
4100:
4098:
4095:
4093:
4090:
4089:
4087:
4068:
4065:
4064:
4061:
4058:
4056:
4053:
4051:
4048:
4046:
4043:
4041:
4038:
4036:
4033:
4032:
4030:
4028:
4027:Intracellular
4024:
4021:
4017:
4007:
4004:
4002:
3999:
3997:
3994:
3992:
3989:
3987:
3984:
3982:
3979:
3977:
3974:
3972:
3969:
3968:
3965:
3962:
3960:
3957:
3955:
3952:
3950:
3947:
3946:
3943:
3940:
3939:
3937:
3935:
3934:Intracellular
3931:
3925:
3922:
3920:
3917:
3916:
3914:
3912:
3908:
3902:
3899:
3898:
3896:
3894:
3890:
3887:
3885:
3881:
3867:
3864:
3862:
3859:
3857:
3854:
3853:
3850:
3847:
3845:
3841:
3839:
3836:
3834:
3831:
3830:
3828:
3826:
3825:
3820:
3814:
3811:
3809:
3806:
3804:
3801:
3800:
3797:
3794:
3792:
3789:
3787:
3784:
3783:
3780:
3777:
3775:
3772:
3771:
3768:
3765:
3764:
3761:
3758:
3756:
3755:Intracellular
3752:
3746:
3743:
3742:
3740:
3738:
3734:
3728:
3725:
3724:
3722:
3720:
3716:
3713:
3711:
3707:
3703:
3700:
3693:
3688:
3686:
3681:
3679:
3674:
3673:
3670:
3656:
3650:
3645:
3641:
3632:
3627:
3625:
3620:
3618:
3613:
3612:
3609:
3602:
3598:
3597:
3592:
3588:
3584:
3581:
3577:
3576:
3571:
3567:
3563:
3560:
3556:
3555:
3550:
3549:
3544:
3543:
3539:
3531:
3527:
3522:
3517:
3513:
3509:
3505:
3501:
3497:
3490:
3488:
3484:
3479:
3475:
3470:
3465:
3461:
3457:
3453:
3449:
3445:
3438:
3435:
3430:
3426:
3421:
3416:
3412:
3408:
3407:J. Biol. Chem
3404:
3397:
3394:
3389:
3385:
3380:
3375:
3371:
3367:
3363:
3356:
3353:
3348:
3344:
3340:
3336:
3332:
3328:
3324:
3320:
3312:
3309:
3304:
3300:
3295:
3290:
3286:
3282:
3281:J. Biol. Chem
3278:
3271:
3268:
3263:
3259:
3254:
3249:
3245:
3241:
3240:J. Biol. Chem
3237:
3230:
3227:
3222:
3218:
3213:
3208:
3204:
3200:
3196:
3192:
3188:
3181:
3178:
3173:
3169:
3165:
3161:
3157:
3153:
3152:Anal. Biochem
3146:
3143:
3138:
3134:
3130:
3126:
3122:
3121:10.1038/71316
3118:
3114:
3110:
3103:
3100:
3095:
3091:
3087:
3083:
3078:
3073:
3070:(4): 527–40.
3069:
3065:
3061:
3054:
3051:
3046:
3042:
3038:
3034:
3030:
3026:
3025:DNA Cell Biol
3019:
3016:
3011:
3007:
3003:
2999:
2995:
2991:
2987:
2983:
2976:
2974:
2970:
2965:
2961:
2957:
2953:
2948:
2943:
2939:
2935:
2931:
2924:
2921:
2916:
2912:
2909:(6): 1791–8.
2908:
2904:
2896:
2893:
2888:
2884:
2880:
2876:
2869:
2866:
2861:
2857:
2852:
2847:
2843:
2839:
2838:J. Biol. Chem
2835:
2828:
2826:
2822:
2817:
2813:
2808:
2803:
2799:
2795:
2791:
2783:
2780:
2775:
2771:
2766:
2761:
2758:(3): 238–40.
2757:
2753:
2749:
2742:
2739:
2734:
2730:
2726:
2722:
2719:(4): 989–96.
2718:
2714:
2707:
2705:
2701:
2696:
2692:
2687:
2682:
2678:
2674:
2670:
2666:
2662:
2655:
2652:
2647:
2643:
2639:
2635:
2632:(2): 222–34.
2631:
2627:
2620:
2618:
2614:
2609:
2605:
2600:
2595:
2591:
2587:
2583:
2579:
2575:
2568:
2565:
2560:
2556:
2551:
2546:
2541:
2536:
2532:
2528:
2524:
2520:
2516:
2509:
2506:
2501:
2497:
2492:
2487:
2483:
2479:
2475:
2471:
2467:
2460:
2457:
2444:
2440:
2434:
2431:
2426:
2422:
2417:
2412:
2408:
2404:
2400:
2396:
2392:
2385:
2383:
2381:
2379:
2377:
2375:
2373:
2371:
2367:
2362:
2358:
2353:
2348:
2343:
2338:
2334:
2330:
2326:
2322:
2318:
2311:
2309:
2307:
2305:
2301:
2296:
2292:
2288:
2284:
2280:
2276:
2273:(4): 609–19.
2272:
2268:
2261:
2259:
2257:
2253:
2248:
2242:
2239:
2227:
2223:
2217:
2214:
2209:
2205:
2199:
2196:
2191:
2187:
2181:
2178:
2174:
2170:
2165:
2163:
2161:
2157:
2153:
2149:
2144:
2142:
2140:
2136:
2130:
2125:
2122:
2120:
2119:Mitochondrion
2117:
2115:
2112:
2110:
2107:
2105:
2102:
2099:
2096:
2094:
2091:
2089:
2086:
2084:
2081:
2080:
2076:
2071:
2068:
2065:
2062:
2059:
2056:
2053:
2050:
2047:
2044:
2041:
2038:
2035:
2032:
2029:
2026:
2023:
2020:
2017:
2014:
2012:
2009:
2006:
2003:
2000:
1997:
1996:
1995:
1993:
1985:
1980:
1973:
1971:
1969:
1965:
1961:
1956:
1953:
1949:
1945:
1941:
1937:
1933:
1929:
1925:
1921:
1913:
1911:
1909:
1905:
1901:
1897:
1893:
1888:
1886:
1882:
1874:
1872:
1870:
1866:
1862:
1858:
1856:
1851:
1847:
1843:
1840:
1836:
1832:
1824:
1822:
1820:
1816:
1812:
1808:
1804:
1801:
1797:
1793:
1789:
1777:
1772:
1768:
1764:
1761:
1757:
1750:
1748:
1745:
1741:
1737:
1733:
1730:
1726:
1722:
1715:
1713:
1707:
1703:
1700:
1694:
1692:
1688:
1684:
1680:
1674:
1670:
1666:
1662:
1658:
1654:
1650:
1647:
1643:
1636:
1634:
1628:
1624:
1621:
1615:
1613:
1609:
1605:
1601:
1595:
1591:
1587:
1583:
1579:
1575:
1571:
1568:
1566:RefSeq (mRNA)
1564:
1557:
1556:
1551:
1547:
1544:
1538:
1537:
1533:
1528:
1524:
1521:
1519:
1515:
1508:
1507:
1502:
1498:
1495:
1489:
1488:
1483:
1479:
1476:
1474:
1470:
1463:
1462:
1457:
1453:
1450:
1444:
1443:
1438:
1434:
1431:
1429:
1425:
1422:
1419:
1417:
1414:
1410:
1407:
1403:
1399:
1392:
1388:
1383:
1377:
1374:
1372:
1369:
1367:
1364:
1362:
1359:
1357:
1354:
1352:
1349:
1347:
1344:
1342:
1339:
1337:
1334:
1332:
1329:
1327:
1324:
1322:
1319:
1317:
1314:
1312:
1309:
1307:
1304:
1302:
1299:
1297:
1294:
1292:
1289:
1287:
1284:
1282:
1279:
1277:
1274:
1272:
1269:
1267:
1264:
1262:
1259:
1257:
1254:
1252:
1249:
1247:
1244:
1242:
1239:
1237:
1234:
1232:
1229:
1227:
1224:
1222:
1219:
1217:
1214:
1212:
1209:
1207:
1204:
1202:
1199:
1197:
1194:
1192:
1189:
1187:
1186:fertilization
1184:
1182:
1179:
1177:
1174:
1172:
1169:
1167:
1164:
1162:
1159:
1157:
1154:
1152:
1149:
1147:
1144:
1142:
1139:
1137:
1134:
1132:
1129:
1127:
1124:
1122:
1119:
1117:
1114:
1112:
1109:
1107:
1104:
1102:
1099:
1097:
1094:
1092:
1089:
1087:
1084:
1082:
1079:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1049:
1047:
1046:viral process
1044:
1042:
1039:
1037:
1034:
1032:
1029:
1027:
1024:
1022:
1019:
1017:
1014:
1012:
1009:
1007:
1004:
1002:
999:
997:
994:
992:
989:
987:
984:
982:
979:
977:
974:
972:
969:
967:
964:
962:
959:
957:
954:
952:
949:
947:
944:
942:
939:
937:
934:
932:
929:
927:
924:
922:
919:
917:
914:
912:
909:
907:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
828:
826:
823:
822:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
750:mitochondrion
748:
746:
743:
741:
738:
736:
733:
731:
728:
727:
725:
722:
721:
715:
712:
710:
709:lipid binding
707:
705:
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
671:
669:
666:
665:
662:
661:Gene ontology
658:
654:
642:
637:
633:
626:
621:
618:
616:
612:
604:
599:
588:
584:
580:
576:
572:
568:
564:
560:
556:
552:
551:
548:
544:
539:
536:
526:
522:
518:
514:
510:
506:
502:
498:
494:
490:
489:
486:
482:
477:
474:
473:
470:
468:
464:
462:
461:
457:
456:
453:
451:
447:
443:
439:
435:
427:
422:
418:
414:
409:
399:
395:
388:
381:
375:
368:
360:
356:
352:
347:
343:
338:
334:
326:
321:
317:
313:
308:
298:
294:
287:
280:
274:
267:
263:
257:
253:
249:
244:
240:
235:
231:
227:
223:
219:
215:
211:
207:
203:
199:
195:
191:
183:
178:
171:
166:
161:
150:
148:
144:
140:
136:
132:
128:
124:
120:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
74:
69:
66:
65:
61:
58:
51:
47:
42:
38:
34:
29:
24:
21:
16:
3855:
3832:
3824:Bcl-2 family
3822:
3803:Cytochrome c
3745:Fas receptor
3654:
3594:
3573:
3553:
3547:
3506:(5): e1266.
3503:
3499:
3451:
3447:
3437:
3410:
3406:
3396:
3369:
3365:
3355:
3322:
3318:
3311:
3284:
3280:
3270:
3243:
3239:
3229:
3194:
3190:
3180:
3155:
3151:
3145:
3112:
3108:
3102:
3067:
3063:
3053:
3031:(6): 351–4.
3028:
3024:
3018:
2985:
2981:
2940:(2): 293–9.
2937:
2933:
2923:
2906:
2902:
2895:
2878:
2874:
2868:
2841:
2837:
2797:
2793:
2782:
2755:
2751:
2741:
2716:
2712:
2668:
2665:J. Cell Biol
2664:
2654:
2629:
2625:
2581:
2577:
2567:
2522:
2518:
2508:
2473:
2469:
2459:
2447:. Retrieved
2443:the original
2433:
2398:
2394:
2324:
2320:
2270:
2266:
2241:
2229:. Retrieved
2225:
2216:
2207:
2198:
2189:
2180:
2109:Cytochrome c
1989:
1974:Interactions
1957:
1951:
1947:
1939:
1935:
1919:
1917:
1904:cytochrome c
1889:
1878:
1864:
1859:
1830:
1828:
1815:cytochrome c
1806:
1799:
1791:
1787:
1786:
1709:
1676:
1665:NP_001278360
1661:NP_001278359
1657:NP_001278358
1653:NP_001278357
1630:
1597:
1586:NM_001291431
1582:NM_001291430
1578:NM_001291429
1574:NM_001291428
1553:
1530:
1504:
1485:
1459:
1440:
1420:
1415:
785:pore complex
589:right kidney
465:
458:
185:External IDs
76:
20:
15:
3637:PDB gallery
3158:(1): 70–5.
2449:20 December
2070:cardiolipin
2064:cholesterol
770:BAX complex
573:neural tube
507:gallbladder
499:granulocyte
424:45,116,322
411:45,111,121
323:48,961,798
310:48,954,815
163:Identifiers
4086:Categories
3727:Fas ligand
3115:(1): 1–6.
2175:, May 2017
2154:, May 2017
2131:References
2088:Apoptosome
1964:paclitaxel
511:right lung
469:(ortholog)
206:HomoloGene
4097:Apoptosis
3959:Caspase 3
3954:Caspase 8
3813:Caspase 3
3808:Caspase 9
3791:Caspase 8
3699:Apoptosis
2752:Autophagy
2222:"UniProt"
2083:Apoptosis
1984:apoptosis
1885:signaling
1861:Orthologs
1835:apoptotic
1825:Structure
1712:NP_031553
1687:NP_620119
1683:NP_620118
1679:NP_620116
1669:NP_004315
1633:NM_007527
1612:NM_138764
1608:NM_138763
1604:NM_138762
1600:NM_138761
1590:NM_004324
1406:Orthologs
805:cytoplasm
214:GeneCards
4107:Proteins
4050:Survivin
3911:Receptor
3884:TNF path
3737:Receptor
3710:Fas path
3530:24874738
3478:21255726
3429:12426317
3388:18274553
3303:11259440
3262:10753914
3221:12853473
3172:12137781
3137:52847351
3129:10620799
3094:17808479
3086:14980220
3045:15231068
3010:44240363
2982:Oncogene
2964:14495370
2903:Oncogene
2875:Oncogene
2860:15637055
2816:29472455
2774:16874066
2733:12767928
2646:11161816
2626:Genomics
2608:10228148
2425:24162660
2295:31151334
2231:30 April
2171:–
2150:–
2104:Caspases
2077:See also
1992:interact
1926:protein
1908:caspases
1875:Function
1850:homology
1760:Wikidata
1385:Sources:
740:membrane
581:calvaria
565:yolk sac
557:epiblast
503:monocyte
302:19q13.33
4060:c-IAP-2
4055:c-IAP-1
3601:PDBe-KB
3591:UniProt
3580:PDBe-KB
3570:UniProt
3521:4047880
3469:3072068
3347:9748162
3327:Bibcode
3319:Science
3002:9824152
2956:7834749
2915:8183578
2887:8183579
2794:Science
2695:9382873
2686:2140220
2599:1171316
2559:9108035
2527:Bibcode
2500:9670005
2491:1170723
2416:3890949
2361:7644501
2329:Bibcode
2287:8358790
2173:Ensembl
2152:Ensembl
2022:SLC25A4
2016:SH3GLB1
1960:ABT-737
1952:in vivo
1881:cytosol
1869:mammals
1863:of the
1846:domains
1796:protein
1794:, is a
1518:UniProt
1473:Ensembl
1412:Species
1391:QuickGO
755:nucleus
730:cytosol
444:pattern
170:Aliases
3893:Ligand
3866:Bcl-xL
3719:Ligand
3596:Q07813
3575:Q07812
3545:Human
3528:
3518:
3476:
3466:
3427:
3386:
3345:
3301:
3260:
3219:
3212:165613
3209:
3191:EMBO J
3170:
3135:
3127:
3092:
3084:
3043:
3008:
3000:
2962:
2954:
2913:
2885:
2858:
2814:
2772:
2731:
2693:
2683:
2644:
2606:
2596:
2578:EMBO J
2557:
2547:
2498:
2488:
2470:EMBO J
2423:
2413:
2359:
2349:
2293:
2285:
2126:(PUMA)
2011:BCL2A1
2005:BCL2L1
1994:with:
1746:search
1744:PubMed
1555:Q07813
1536:Q5ZPJ0
1532:Q07812
1428:Entrez
615:BioGPS
561:embryo
553:embryo
523:spleen
515:rectum
194:600040
4019:Other
4006:NF-κB
3981:MEKK1
3976:ASK-1
3971:TRAF2
3942:TRADD
3861:Bcl-2
3842:BAK1/
3133:S2CID
3090:S2CID
3006:S2CID
2960:S2CID
2550:20498
2352:41240
2291:S2CID
2100:(BID)
2093:Bcl-2
2066:, and
2054:Noxa,
2051:Puma,
2040:YWHAQ
2028:VDAC1
1999:Bcl-2
1948:BAX's
1839:Bcl-2
1461:12028
1421:Mouse
1416:Human
1387:Amigo
467:Mouse
460:Human
407:Start
342:Mouse
306:Start
239:Human
202:99702
4045:NAIP
4040:XIAP
4035:IAPs
3996:MKK7
3991:IκBα
3949:FADD
3786:FADD
3779:ASK1
3774:DAXX
3655:1f16
3589:for
3568:for
3526:PMID
3474:PMID
3425:PMID
3384:PMID
3343:PMID
3299:PMID
3258:PMID
3217:PMID
3168:PMID
3125:PMID
3082:PMID
3064:Cell
3041:PMID
2998:PMID
2952:PMID
2934:Cell
2911:PMID
2883:PMID
2856:PMID
2812:PMID
2770:PMID
2729:PMID
2691:PMID
2642:PMID
2604:PMID
2555:PMID
2496:PMID
2451:2009
2421:PMID
2357:PMID
2283:PMID
2267:Cell
2233:2023
2114:Noxa
2058:Mfn2
2048:Bim,
2045:Bid,
2034:TCTP
1892:VDAC
1829:The
1803:gene
450:Bgee
398:Band
359:Chr.
297:Band
256:Chr.
210:7242
190:OMIM
147:4S0O
143:4ZII
139:4ZIH
135:4ZIG
131:4ZIF
127:4ZIE
123:4UF2
119:4BD8
115:4BD7
111:4BD6
107:4BD2
103:3PL7
99:3PK1
95:2LR1
91:2K7W
87:2G5B
83:1F16
79:4BDU
60:RCSB
57:PDBe
4001:JNK
3986:IKK
3964:BID
3838:BAX
3796:BID
3587:PDB
3566:PDB
3554:BAX
3548:BAX
3516:PMC
3508:doi
3464:PMC
3456:doi
3415:doi
3411:278
3374:doi
3335:doi
3323:281
3289:doi
3285:276
3248:doi
3244:275
3207:PMC
3199:doi
3160:doi
3156:307
3117:doi
3072:doi
3068:116
3033:doi
2990:doi
2942:doi
2846:doi
2842:280
2802:doi
2798:359
2760:doi
2721:doi
2717:305
2681:PMC
2673:doi
2669:139
2634:doi
2594:PMC
2586:doi
2545:PMC
2535:doi
2486:PMC
2478:doi
2411:PMC
2403:doi
2347:PMC
2337:doi
2275:doi
1944:p53
1940:BAX
1936:BAX
1928:p53
1920:BAX
1900:MAC
1896:Bak
1865:BAX
1848:of
1831:BAX
1819:P53
1807:BAX
1800:BAX
1442:581
420:End
319:End
222:OMA
218:BAX
198:MGI
177:BAX
50:PDB
26:BAX
4088::
3593::
3572::
3524:.
3514:.
3502:.
3498:.
3486:^
3472:.
3462:.
3452:41
3450:.
3446:.
3423:.
3409:.
3405:.
3382:.
3370:15
3368:.
3364:.
3341:.
3333:.
3321:.
3297:.
3283:.
3279:.
3256:.
3242:.
3238:.
3215:.
3205:.
3195:22
3193:.
3189:.
3166:.
3154:.
3131:.
3123:.
3111:.
3088:.
3080:.
3066:.
3062:.
3039:.
3029:23
3027:.
3004:.
2996:.
2986:17
2984:.
2972:^
2958:.
2950:.
2938:80
2936:.
2932:.
2905:.
2877:.
2854:.
2840:.
2836:.
2824:^
2810:.
2796:.
2792:.
2768:.
2754:.
2750:.
2727:.
2715:.
2703:^
2689:.
2679:.
2667:.
2663:.
2640:.
2630:71
2628:.
2616:^
2602:.
2592:.
2582:18
2580:.
2576:.
2553:.
2543:.
2533:.
2523:94
2521:.
2517:.
2494:.
2484:.
2474:17
2472:.
2468:.
2419:.
2409:.
2399:21
2397:.
2393:.
2369:^
2355:.
2345:.
2335:.
2325:92
2323:.
2319:.
2303:^
2289:.
2281:.
2271:74
2269:.
2255:^
2224:.
2206:.
2188:.
2159:^
2138:^
1805:.
1389:/
426:bp
413:bp
325:bp
312:bp
220:;
216::
212:;
208::
204:;
200::
196:;
192::
145:,
141:,
137:,
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