336:
2687:
690:(marketed as Epogen) and darbepoetin alfa. The advisory recommended caution in using these agents in cancer patients receiving chemotherapy or off chemotherapy, and indicated a lack of clinical evidence to support improvements in quality of life or transfusion requirements in these settings.
482:
containing 5 amino acid changes (N30, T32, V87, N88, T90) resulting in the creation of 2 new sites for N-linked carbohydrate addition. It has a 3-fold longer serum half-life compared to epoetin alpha and epoetin beta. It stimulates
620:. A recent study has extended these findings to treatment of patients exhibiting cancer-related anemia (distinct from anemia resulting from chemotherapy). Other reported adverse reactions include increased risk of
674:
10 clinical trial. The DAHANCA 10 data monitoring committee found that 3-year loco-regional control in subjects treated with
Aranesp was significantly worse than for those not receiving Aranesp (p=0.01).
663:
Amgen sent a "dear stockholders" letter in
January 2007, that highlighted results from a recent anemia of cancer trial, and warned doctors to consider use in that off-label indication with caution.
196:
1215:
1832:
597:
progression or recurrence. To avoid side effects, it is recommended for patients with chronic kidney failure or cancer to use the lowest possible dose needed to avoid red blood cell (RBC)
1616:
151:
1216:"American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update on the use of epoetin and darbepoetin in adult patients with cancer"
410:
1337:
1848:
2310:
1776:
1898:
45:
2330:
561:
Use of darbepoetin alfa is contraindicated in patients with hypersensitivity to the drug, pre-existing uncontrolled hypertension, and pure red cell aplasia.
1073:
1151:"FDA Public Health Advisory: Erythropoiesis-Stimulating Agents (ESAs): Epoetin alfa (marketed as Procrit, Epogen), Darbepoetin alfa (marketed as Aranesp)"
2717:
1958:
1609:
1253:
518:
for treatment of anemia in patients with chronic kidney failure by intravenous or subcutaneous injection. In June 2001, it had been approved by the
2301:
2290:
2266:
1756:
1377:
539:. It differs from endogenous erythropoietin (EPO) by containing two more N-linked oligosaccharide chains. It is an erythropoiesis-stimulating 165-
528:
launched darbepoetin alfa in India under the brand name Cresp in August 2010. This is the world's first follow-on biologic of darbepoetin alfa.
1645:
1792:
1602:
1330:
868:
701:(ASH), use of ESAs such as darbepoetin alfa in cancer patients is appropriate when following stipulations outlined in FDA-approved labeling.
694:
550:
842:
604:
In addition to those listed in the black box warning, use of darbepoetin alfa also increases the risk of cardiovascular problems, including
1924:
1182:
1656:
2610:
431:
2707:
1534:
1323:
683:
1150:
994:
1475:
181:
77:
2321:
2023:
698:
96:
709:
Like EPO, darbepoetin alfa has the potential to be abused by athletes seeking a competitive advantage. Its use during the
2625:
1187:
1155:
902:"Novel erythropoiesis stimulating protein (NESP) for the treatment of anaemia of chronic disease associated with cancer"
714:
667:
515:
295:
736:
Epogen and
Aranesp had more than $ 6 billion in combined sales in 2006. Procrit sales were about $ 3.2 billion in 2006.
315:
525:
2677:
2615:
2257:
1504:
652:
536:
2216:
1686:
1400:
949:
710:
519:
1077:
613:
1445:
2712:
1969:
1665:
679:
648:
133:
1681:
2354:
586:
496:
144:
1020:
787:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
2722:
2166:
2161:
2112:
578:
1751:
1415:
1410:
491:
levels) by the same mechanism as rHuEpo (binding and activating the Epo receptor) and is used to treat
1766:
875:
2281:
2117:
1822:
1716:
1430:
786:
2524:
1450:
2232:
2122:
2014:
1731:
1726:
1721:
1711:
522:
for this indication as well as the treatment of anemia in cancer patients undergoing chemotherapy.
331:
239:
1985:
1843:
1812:
1214:
Rizzo JD, Brouwers M, Hurley P, Seidenfeld J, Arcasoy MO, Spivak JL, et al. (November 2010).
2146:
2141:
2107:
2102:
2048:
1863:
1636:
1628:
1440:
1420:
846:
107:
2635:
1939:
1929:
1919:
1853:
1802:
900:
Smith RE, Jaiyesimi IA, Meza LA, Tchekmedyian NS, Chan D, Griffith H, et al. (April 2001).
2564:
2554:
2544:
2481:
2206:
1909:
1294:
2574:
2559:
2476:
2441:
2186:
1691:
1625:
1455:
1435:
1425:
1245:
1192:
1132:
1054:
931:
725:
598:
2501:
1676:
2227:
2156:
2151:
2039:
1509:
1465:
1460:
1235:
1227:
1122:
1112:
957:
921:
913:
815:
437:
352:
248:
2135:
304:
2691:
2605:
2582:
2127:
2044:
1807:
1392:
717:
532:
335:
1268:
1101:"Flexible dosing with Darbepoetin alfa for the treatment of chemotherapy-induced anemia"
760:
682:
on 9 March 2007, and a clinical alert for doctors on 16 February 2007, about the use of
55:
2466:
2456:
2383:
2000:
1990:
1914:
1746:
1499:
1367:
1359:
1240:
1127:
1100:
926:
901:
737:
605:
488:
484:
479:
2701:
2034:
1817:
1736:
1405:
1160:
721:
570:
209:
69:
2640:
2620:
2539:
2529:
2471:
2418:
2348:
2247:
2191:
1878:
1868:
1858:
1761:
1741:
1706:
1701:
1583:
1470:
1382:
1350:
1183:"Information for Healthcare Professionals: Erythropoiesis Stimulating Agents (ESA)"
687:
609:
500:
164:
159:
995:"Aranesp- darbepoetin alfa injection, solution Aranesp- darbepoetin alfa solution"
33:
2650:
2645:
2549:
2534:
2506:
2496:
2491:
2446:
2413:
2408:
2403:
2398:
2393:
2378:
2373:
2196:
2181:
2176:
1995:
1980:
1797:
1552:
1542:
1519:
1485:
1315:
1046:
625:
140:
63:
1594:
2486:
2388:
2242:
1787:
1567:
1562:
1557:
1547:
1524:
1514:
1490:
1117:
590:
540:
391:
279:
1231:
954:
World Health
Organization model list of essential medicines: 22nd list (2021)
2660:
2655:
2436:
1883:
636:
Darbepoetin alfa is not assigned a pregnancy category in the United States.
49:
1249:
1136:
1058:
935:
917:
1888:
259:
91:
962:
268:
671:
621:
543:
17:
693:
According to the 2010 update to clinical practice guidelines from the
2461:
2451:
2096:
2092:
2088:
2084:
2080:
2076:
1346:
981:"Darbepoetin Alfa (Lexi-Drugs)". LexiComp. Retrieved 29 October 2014.
582:
492:
2131:
2072:
2068:
2064:
2060:
2056:
2052:
1949:
617:
594:
574:
504:
2516:
2428:
2365:
639:
It is not known if darbepoetin alfa is excreted in breast milk.
218:
1598:
1319:
203:
86:
794:
845:. United States Food and Drug Administration. Archived from
443:
320:
458:
449:
190:
118:
514:
The medication was approved in
September 2001, by the US
467:
461:
874:. European Medicines Agency. 8 June 2001. Archived from
1757:
Methoxy polyethylene glycol-epoetin beta (CERA/Mircera)
551:
417:
713:
to improve performance led to the disqualification of
2675:
755:
753:
751:
470:
678:
In response to these advisories, the FDA released a
464:
455:
446:
440:
2595:
2573:
2515:
2427:
2364:
2347:
2340:
2320:
2300:
2280:
2256:
2215:
2022:
2013:
1968:
1948:
1897:
1831:
1775:
1664:
1655:
1635:
1576:
1533:
1484:
1391:
1358:
1021:"Amgen Finds Anemia Drug Holds Risks in Cancer Use"
989:
987:
452:
390:
351:
346:
314:
294:
278:
258:
238:
233:
180:
175:
150:
132:
106:
76:
62:
44:
39:
655:, stimulating RBC production and differentiation.
843:"Product Approval Information - Licensing Action"
761:"Darbepoetin alfa (Aranesp) Use During Pregnancy"
1849:Granulocyte macrophage colony-stimulating factor
1074:"Amgen 2007 Annual Report and Financial Summary"
1099:Wauters I, Pat K, Vansteenkiste J (June 2006).
1053:. Treasure Island (FL): StatPearls Publishing.
247:
869:"European Public Assessment Report (Abstract)"
1610:
1331:
8:
95:
32:
659:Safety advisories in anemic cancer patients
573:in the United States for increased risk of
226:In general: ℞ (Prescription only)
2616:Leukemia/leukocyte inhibitory factor (LIF)
2361:
2344:
2019:
1661:
1617:
1603:
1595:
1338:
1324:
1316:
334:
2611:FMS-like tyrosine kinase 3 ligand (FLT3L)
2040:Interferon alpha (interferon alfa, IFN-α)
1239:
1126:
1116:
1105:Therapeutics and Clinical Risk Management
961:
925:
303:
2633:Additional cytokine receptor modulators:
1378:Methoxy polyethylene glycol-epoetin beta
1045:Vest LS, Patel P, Patel JB (June 2024).
684:erythropoeisis-stimulating agents (ESAs)
2682:
1267:McGrath M, Portal G (30 January 2002).
747:
330:
267:
68:
2457:Cucurbitacin I (elatericin B, JSI-124)
977:
975:
973:
31:
1793:Granulocyte colony-stimulating factor
956:. Geneva: World Health Organization.
695:American Society of Clinical Oncology
54:
7:
2152:Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
1925:Macrophage colony-stimulating factor
163:
2626:Thymic stromal lymphopoietin (TSLP)
25:
2718:Erythropoiesis-stimulating agents
1535:HIF prolyl-hydroxylase inhibitors
728:of Spain from their final races.
2685:
1269:"New drugs give cheats the edge"
436:
369:
363:
2157:Interferon omega (IFN-ω, IFNW1)
1476:Sodium ferric gluconate complex
841:Siegel JP (17 September 2001).
670:(FDA) as to the results of the
1293:staff-author (14 March 2007).
699:American Society of Hematology
647:Darbepoetin alfa binds to the
381:
375:
357:
1:
1505:Cyanocobalamin tannin complex
1019:Pollack A (26 January 2007).
503:. Darbepoetin is marketed by
1299:Los Angeles Business Journal
1220:Journal of Clinical Oncology
1188:Food and Drug Administration
1156:Food and Drug Administration
668:Food and Drug Administration
516:Food and Drug Administration
2001:Thrombopoietin (THPO, MGDF)
1767:Pegol sihematide (EPO-018B)
1687:Carbamylated erythropoietin
537:Chinese hamster ovary cells
531:Darbepoetin is produced by
495:, commonly associated with
478:is a re-engineered form of
2739:
1295:"FDA to Study Amgen Drugs"
966:. WHO/MHP/HPS/EML/2021.02.
653:erythroid progenitor cells
347:Chemical and physical data
2550:Tofacitinib (tasocitinib)
2507:Tofacitinib (tasocitinib)
2414:Tofacitinib (tasocitinib)
1118:10.2147/tcrm.2006.2.2.175
950:World Health Organization
906:British Journal of Cancer
820:European Medicines Agency
711:2002 Winter Olympic Games
520:European Medicines Agency
407:
2228:Interferon gamma (IFN-γ)
1232:10.1200/jco.2010.29.2201
614:congestive heart failure
593:of vascular access, and
526:Dr. Reddy's Laboratories
2708:Antianemic preparations
2128:Interferon beta (IFN-β)
1446:Ferrous glycine sulfate
1347:Antianemic preparations
666:Amgen advised the U.S.
649:erythropoietin receptor
632:Pregnancy and lactation
535:technology in modified
2606:Cardiotrophin 1 (CT-1)
918:10.1054/bjoc.2001.1749
680:Public Health Advisory
587:venous thromboembolism
497:chronic kidney failure
2603:Additional cytokines:
2530:Decernotinib (VX-509)
2167:Peginterferon alfa-2b
2162:Peginterferon alfa-2a
1682:Asialo erythropoietin
579:myocardial infarction
569:Darbepoetin alfa has
507:under the trade name
2118:Interferon alfacon-1
1747:Erythropoietin (EPO)
1431:Ferric derisomaltose
715:cross-country skiers
2265:See IL-28R (IFNLR)
2233:Interferon gamma 1b
2123:Interferon alpha-n3
1256:on 3 November 2014.
705:Society and culture
643:Mechanism of action
199:(Prescription only)
36:
27:Pharmaceutical drug
2621:Oncostatin M (OSM)
2147:Interferon beta 1b
2142:Interferon beta 1a
2113:Interferon alfa n1
2108:Interferon alfa 2b
2103:Interferon alfa 2a
1937:Kinase inhibitors:
1080:on 24 January 2022
1025:The New York Times
912:(Suppl 1): 24–30.
881:on 17 October 2006
849:on 22 October 2006
767:. 31 December 2018
628:, and chest pain.
571:black box warnings
2673:
2672:
2669:
2668:
2591:
2590:
2358:
2276:
2275:
2009:
2008:
1752:Erythropoietin-Fc
1626:Cytokine receptor
1592:
1591:
1456:Ferrous succinate
1441:Ferrous gluconate
1421:Ferrous carbonate
1416:Ferrous aspartate
1411:Ferrous ascorbate
1226:(33): 4996–5010.
557:Contraindications
425:
424:
316:CompTox Dashboard
222:
207:
194:
122:
89:
16:(Redirected from
2730:
2690:
2689:
2688:
2681:
2362:
2352:
2345:
2204:Decoy receptors:
2020:
1697:Darbepoetin alfa
1662:
1619:
1612:
1605:
1596:
1510:Hydroxocobalamin
1466:Ferrous tartrate
1436:Ferrous fumarate
1426:Ferrous chloride
1401:Ferric hydroxide
1393:Iron supplements
1373:Darbepoetin alfa
1340:
1333:
1326:
1317:
1310:
1309:
1307:
1305:
1290:
1284:
1283:
1281:
1279:
1264:
1258:
1257:
1252:. Archived from
1243:
1211:
1205:
1204:
1202:
1200:
1191:. Archived from
1179:
1173:
1172:
1170:
1168:
1159:. Archived from
1147:
1141:
1140:
1130:
1120:
1096:
1090:
1089:
1087:
1085:
1076:. Archived from
1069:
1063:
1062:
1042:
1036:
1035:
1033:
1031:
1016:
1010:
1009:
1007:
1005:
991:
982:
979:
968:
967:
965:
946:
940:
939:
929:
897:
891:
890:
888:
886:
880:
873:
865:
859:
858:
856:
854:
838:
832:
831:
829:
827:
812:
806:
805:
803:
801:
791:nctr-crs.fda.gov
783:
777:
776:
774:
772:
757:
477:
476:
473:
472:
469:
466:
463:
460:
457:
454:
451:
448:
445:
442:
428:Darbepoetin alfa
421:
420:
413:
402:
400:
383:
377:
371:
365:
359:
339:
338:
324:
322:
307:
271:
251:
220:
217:
212:
205:
202:
192:
189:
167:
120:
117:
99:
97:Darbepoetin alfa
88:
85:
72:
58:
37:
35:
34:Darbepoetin alfa
21:
2738:
2737:
2733:
2732:
2731:
2729:
2728:
2727:
2698:
2697:
2696:
2686:
2684:
2676:
2674:
2665:
2587:
2583:Deucravacitinib
2569:
2511:
2423:
2351:
2336:
2316:
2296:
2272:
2252:
2211:
2045:Interferon alfa
2005:
1964:
1944:
1893:
1827:
1823:Pegnartograstim
1808:Lipegfilgrastim
1771:
1717:Epoetin epsilon
1651:
1631:
1623:
1593:
1588:
1572:
1529:
1489:
1480:
1461:Ferrous sulfate
1387:
1360:Erythropoietins
1354:
1344:
1314:
1313:
1303:
1301:
1292:
1291:
1287:
1277:
1275:
1273:BBC News Online
1266:
1265:
1261:
1213:
1212:
1208:
1198:
1196:
1181:
1180:
1176:
1166:
1164:
1149:
1148:
1144:
1098:
1097:
1093:
1083:
1081:
1071:
1070:
1066:
1044:
1043:
1039:
1029:
1027:
1018:
1017:
1013:
1003:
1001:
993:
992:
985:
980:
971:
948:
947:
943:
899:
898:
894:
884:
882:
878:
871:
867:
866:
862:
852:
850:
840:
839:
835:
825:
823:
814:
813:
809:
799:
797:
785:
784:
780:
770:
768:
759:
758:
749:
744:
734:
718:Larisa Lazutina
707:
697:(ASCO) and the
661:
645:
634:
567:
565:Adverse effects
559:
533:recombinant DNA
439:
435:
416:
414:
411:(what is this?)
408:
398:
396:
386:
380:
374:
368:
362:
342:
318:
310:
290:
274:
254:
229:
210:
171:
135:
128:
109:
102:
28:
23:
22:
15:
12:
11:
5:
2736:
2734:
2726:
2725:
2720:
2715:
2713:Growth factors
2710:
2700:
2699:
2695:
2694:
2671:
2670:
2667:
2666:
2664:
2663:
2658:
2653:
2648:
2643:
2638:
2629:
2628:
2623:
2618:
2613:
2608:
2599:
2597:
2593:
2592:
2589:
2588:
2586:
2585:
2579:
2577:
2571:
2570:
2568:
2567:
2562:
2557:
2552:
2547:
2542:
2537:
2532:
2527:
2525:Cercosporamide
2521:
2519:
2513:
2512:
2510:
2509:
2504:
2499:
2494:
2489:
2484:
2479:
2474:
2469:
2467:Deuruxolitinib
2464:
2459:
2454:
2449:
2444:
2439:
2433:
2431:
2425:
2424:
2422:
2421:
2416:
2411:
2406:
2401:
2396:
2391:
2386:
2384:Deuruxolitinib
2381:
2376:
2370:
2368:
2359:
2342:
2338:
2337:
2335:
2334:
2326:
2324:
2318:
2317:
2315:
2314:
2306:
2304:
2298:
2297:
2295:
2294:
2286:
2284:
2278:
2277:
2274:
2273:
2271:
2270:
2262:
2260:
2258:IFNLR (λ, III)
2254:
2253:
2251:
2250:
2245:
2236:
2235:
2230:
2221:
2219:
2213:
2212:
2210:
2209:
2200:
2199:
2194:
2189:
2184:
2179:
2170:
2169:
2164:
2159:
2154:
2149:
2144:
2139:
2125:
2120:
2115:
2110:
2105:
2100:
2042:
2037:
2028:
2026:
2024:IFNAR (α/β, I)
2017:
2011:
2010:
2007:
2006:
2004:
2003:
1998:
1993:
1991:Promegapoietin
1988:
1983:
1974:
1972:
1970:Thrombopoietin
1966:
1965:
1963:
1962:
1954:
1952:
1946:
1945:
1943:
1942:
1933:
1932:
1927:
1922:
1917:
1915:Interleukin-34
1912:
1903:
1901:
1895:
1894:
1892:
1891:
1886:
1881:
1872:
1871:
1866:
1861:
1856:
1851:
1846:
1837:
1835:
1829:
1828:
1826:
1825:
1820:
1815:
1810:
1805:
1800:
1795:
1790:
1781:
1779:
1773:
1772:
1770:
1769:
1764:
1759:
1754:
1749:
1744:
1739:
1734:
1729:
1724:
1719:
1714:
1709:
1704:
1699:
1694:
1689:
1684:
1679:
1670:
1668:
1666:Erythropoietin
1659:
1653:
1652:
1650:
1649:
1641:
1639:
1633:
1632:
1624:
1622:
1621:
1614:
1607:
1599:
1590:
1589:
1587:
1586:
1580:
1578:
1574:
1573:
1571:
1570:
1565:
1560:
1555:
1550:
1545:
1539:
1537:
1531:
1530:
1528:
1527:
1522:
1517:
1512:
1507:
1502:
1500:Cyanocobalamin
1496:
1494:
1482:
1481:
1479:
1478:
1473:
1468:
1463:
1458:
1453:
1451:Ferrous iodine
1448:
1443:
1438:
1433:
1428:
1423:
1418:
1413:
1408:
1403:
1397:
1395:
1389:
1388:
1386:
1385:
1380:
1375:
1370:
1368:Erythropoietin
1364:
1362:
1356:
1355:
1345:
1343:
1342:
1335:
1328:
1320:
1312:
1311:
1285:
1259:
1206:
1195:on 15 May 2007
1174:
1163:on 28 May 2007
1142:
1111:(2): 175–186.
1091:
1072:Amgen (2007).
1064:
1047:"Epoetin Alfa"
1037:
1011:
983:
969:
941:
892:
860:
833:
816:"Aranesp EPAR"
807:
778:
746:
745:
743:
740:
733:
730:
726:Johann Mühlegg
724:of Russia and
706:
703:
660:
657:
644:
641:
633:
630:
608:, arrhythmia,
606:cardiac arrest
566:
563:
558:
555:
489:red blood cell
485:erythropoiesis
480:erythropoietin
423:
422:
405:
404:
394:
388:
387:
384:
378:
372:
366:
360:
355:
349:
348:
344:
343:
341:
340:
327:
325:
312:
311:
309:
308:
300:
298:
292:
291:
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284:
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276:
275:
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264:
262:
256:
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253:
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244:
242:
236:
235:
231:
230:
228:
227:
224:
215:
200:
186:
184:
178:
177:
173:
172:
170:
169:
156:
154:
148:
147:
138:
136:administration
130:
129:
127:
126:
124:
114:
112:
104:
103:
101:
100:
82:
80:
74:
73:
66:
60:
59:
52:
42:
41:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2735:
2724:
2721:
2719:
2716:
2714:
2711:
2709:
2706:
2705:
2703:
2693:
2683:
2679:
2662:
2659:
2657:
2654:
2652:
2649:
2647:
2644:
2642:
2639:
2637:
2634:
2631:
2630:
2627:
2624:
2622:
2619:
2617:
2614:
2612:
2609:
2607:
2604:
2601:
2600:
2598:
2594:
2584:
2581:
2580:
2578:
2576:
2572:
2566:
2563:
2561:
2558:
2556:
2553:
2551:
2548:
2546:
2543:
2541:
2538:
2536:
2533:
2531:
2528:
2526:
2523:
2522:
2520:
2518:
2514:
2508:
2505:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2485:
2483:
2480:
2478:
2475:
2473:
2470:
2468:
2465:
2463:
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2453:
2450:
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2426:
2420:
2417:
2415:
2412:
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2402:
2400:
2397:
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2377:
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2363:
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2356:
2350:
2346:
2343:
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2328:
2327:
2325:
2323:
2319:
2312:
2308:
2307:
2305:
2303:
2299:
2292:
2288:
2287:
2285:
2283:
2279:
2268:
2264:
2263:
2261:
2259:
2255:
2249:
2246:
2244:
2241:
2238:
2237:
2234:
2231:
2229:
2226:
2223:
2222:
2220:
2218:
2217:IFNGR (γ, II)
2214:
2208:
2205:
2202:
2201:
2198:
2195:
2193:
2190:
2188:
2185:
2183:
2180:
2178:
2175:
2172:
2171:
2168:
2165:
2163:
2160:
2158:
2155:
2153:
2150:
2148:
2145:
2143:
2140:
2137:
2133:
2129:
2126:
2124:
2121:
2119:
2116:
2114:
2111:
2109:
2106:
2104:
2101:
2098:
2094:
2090:
2086:
2082:
2078:
2074:
2070:
2066:
2062:
2058:
2054:
2050:
2046:
2043:
2041:
2038:
2036:
2035:Albinterferon
2033:
2030:
2029:
2027:
2025:
2021:
2018:
2016:
2012:
2002:
1999:
1997:
1994:
1992:
1989:
1987:
1984:
1982:
1979:
1976:
1975:
1973:
1971:
1967:
1960:
1956:
1955:
1953:
1951:
1947:
1941:
1938:
1935:
1934:
1931:
1928:
1926:
1923:
1921:
1918:
1916:
1913:
1911:
1908:
1905:
1904:
1902:
1900:
1896:
1890:
1887:
1885:
1882:
1880:
1877:
1874:
1873:
1870:
1867:
1865:
1862:
1860:
1857:
1855:
1852:
1850:
1847:
1845:
1842:
1839:
1838:
1836:
1834:
1833:GM-CSF (CSF2)
1830:
1824:
1821:
1819:
1818:Pegfilgrastim
1816:
1814:
1811:
1809:
1806:
1804:
1801:
1799:
1796:
1794:
1791:
1789:
1786:
1783:
1782:
1780:
1778:
1774:
1768:
1765:
1763:
1760:
1758:
1755:
1753:
1750:
1748:
1745:
1743:
1740:
1738:
1737:Epoetin theta
1735:
1733:
1732:Epoetin omega
1730:
1728:
1727:Epoetin kappa
1725:
1723:
1722:Epoetin gamma
1720:
1718:
1715:
1713:
1712:Epoetin delta
1710:
1708:
1705:
1703:
1700:
1698:
1695:
1693:
1690:
1688:
1685:
1683:
1680:
1678:
1675:
1672:
1671:
1669:
1667:
1663:
1660:
1658:
1654:
1647:
1643:
1642:
1640:
1638:
1634:
1630:
1627:
1620:
1615:
1613:
1608:
1606:
1601:
1600:
1597:
1585:
1582:
1581:
1579:
1575:
1569:
1566:
1564:
1561:
1559:
1556:
1554:
1551:
1549:
1546:
1544:
1541:
1540:
1538:
1536:
1532:
1526:
1523:
1521:
1518:
1516:
1513:
1511:
1508:
1506:
1503:
1501:
1498:
1497:
1495:
1492:
1487:
1483:
1477:
1474:
1472:
1469:
1467:
1464:
1462:
1459:
1457:
1454:
1452:
1449:
1447:
1444:
1442:
1439:
1437:
1434:
1432:
1429:
1427:
1424:
1422:
1419:
1417:
1414:
1412:
1409:
1407:
1406:Ferric maltol
1404:
1402:
1399:
1398:
1396:
1394:
1390:
1384:
1381:
1379:
1376:
1374:
1371:
1369:
1366:
1365:
1363:
1361:
1357:
1352:
1348:
1341:
1336:
1334:
1329:
1327:
1322:
1321:
1318:
1300:
1296:
1289:
1286:
1274:
1270:
1263:
1260:
1255:
1251:
1247:
1242:
1237:
1233:
1229:
1225:
1221:
1217:
1210:
1207:
1194:
1190:
1189:
1184:
1178:
1175:
1162:
1158:
1157:
1152:
1146:
1143:
1138:
1134:
1129:
1124:
1119:
1114:
1110:
1106:
1102:
1095:
1092:
1079:
1075:
1068:
1065:
1060:
1056:
1052:
1048:
1041:
1038:
1026:
1022:
1015:
1012:
1000:
996:
990:
988:
984:
978:
976:
974:
970:
964:
959:
955:
951:
945:
942:
937:
933:
928:
923:
919:
915:
911:
907:
903:
896:
893:
877:
870:
864:
861:
848:
844:
837:
834:
822:. 8 June 2001
821:
817:
811:
808:
796:
792:
788:
782:
779:
766:
762:
756:
754:
752:
748:
741:
739:
738:
731:
729:
727:
723:
722:Olga Danilova
719:
716:
712:
704:
702:
700:
696:
691:
689:
685:
681:
676:
673:
669:
664:
658:
656:
654:
650:
642:
640:
637:
631:
629:
627:
623:
619:
615:
611:
607:
602:
600:
596:
592:
588:
584:
580:
576:
572:
564:
562:
556:
554:
552:
549:It is on the
547:
545:
542:
538:
534:
529:
527:
523:
521:
517:
512:
510:
506:
502:
498:
494:
490:
486:
481:
475:
433:
429:
419:
412:
406:
395:
393:
389:
356:
354:
350:
345:
337:
333:
332:DTXSID7039678
329:
328:
326:
317:
313:
306:
302:
301:
299:
297:
293:
286:
285:
283:
281:
277:
270:
266:
265:
263:
261:
257:
250:
246:
245:
243:
241:
237:
232:
225:
223: Rx-only
216:
213:
201:
198:
188:
187:
185:
183:
179:
174:
166:
161:
158:
157:
155:
153:
149:
146:
142:
139:
137:
131:
125:
116:
115:
113:
111:
105:
98:
93:
84:
83:
81:
79:
75:
71:
67:
65:
61:
57:
53:
51:
47:
43:
40:Clinical data
38:
30:
19:
2723:Orphan drugs
2641:Lestaurtinib
2632:
2602:
2540:Ritlecitinib
2472:Lestaurtinib
2419:Upadacitinib
2248:Fontolizumab
2239:
2224:
2203:
2192:Rontalizumab
2173:
2031:
1986:Pegacaristim
1977:
1936:
1906:
1899:M-CSF (CSF1)
1879:Mavrilimumab
1875:
1869:Sargramostim
1859:Molgramostim
1844:Ecogramostim
1840:
1813:Nartograstim
1784:
1777:G-CSF (CSF3)
1762:Peginesatide
1742:Epoetin zeta
1707:Epoetin beta
1702:Epoetin alfa
1696:
1673:
1584:Luspatercept
1471:Iron sucrose
1383:Peginesatide
1372:
1302:. Retrieved
1298:
1288:
1276:. Retrieved
1272:
1262:
1254:the original
1223:
1219:
1209:
1197:. Retrieved
1193:the original
1186:
1177:
1165:. Retrieved
1161:the original
1154:
1145:
1108:
1104:
1094:
1082:. Retrieved
1078:the original
1067:
1050:
1040:
1028:. Retrieved
1024:
1014:
1002:. Retrieved
998:
963:10665/345533
953:
944:
909:
905:
895:
883:. Retrieved
876:the original
863:
851:. Retrieved
847:the original
836:
824:. Retrieved
819:
810:
798:. Retrieved
790:
781:
769:. Retrieved
764:
735:
708:
692:
688:epoetin alfa
677:
665:
662:
646:
638:
635:
610:hypertension
603:
599:transfusions
568:
560:
548:
530:
524:
513:
508:
501:chemotherapy
427:
426:
415:
409:
182:Legal status
176:Legal status
145:subcutaneous
78:License data
29:
2651:Quizartinib
2646:Midostaurin
2535:Peficitinib
2497:Ruxolitinib
2492:Peficitinib
2447:Baricitinib
2409:Ruxolitinib
2404:Peficitinib
2399:Oclacitinib
2394:Momelotinib
2379:Baricitinib
2374:Abrocitinib
2282:Interleukin
2240:Antibodies:
2197:Sifalimumab
2182:Faralimomab
2177:Anifrolumab
2174:Antibodies:
1996:Romiplostim
1981:Eltrombopag
1950:SCF (c-Kit)
1876:Antibodies:
1864:Regramostim
1798:Lenograstim
1553:Enarodustat
1543:Daprodustat
1520:Mecobalamin
1493:supplements
1486:Vitamin B12
1051:StatPearls
720:of Russia,
626:hypotension
499:and cancer
487:(increases
403: g·mol
249:209810-58-2
234:Identifiers
141:Intravenous
64:MedlinePlus
2702:Categories
2636:Emfilermin
2487:Pacritinib
2389:Filgotinib
2355:inhibitors
2243:Emapalumab
2015:Interferon
1940:Agerafenib
1930:Mirimostim
1920:Lanimostim
1854:Milodistim
1803:Leridistim
1788:Filgrastim
1629:modulators
1568:Vadadustat
1563:Roxadustat
1558:Molidustat
1548:Desidustat
1525:Folic acid
1515:Cobamamide
1491:folic acid
1278:3 November
1084:24 January
1030:27 January
885:27 January
853:27 January
800:22 October
742:References
591:thrombosis
541:amino acid
392:Molar mass
305:15UQ94PT4P
280:ChemSpider
240:CAS Number
2661:Sunitinib
2656:Sorafenib
2565:ZM-449829
2555:WHI-P 154
2545:TCS-21311
2482:NSC-33994
2437:Atiprimod
2225:Agonists:
2207:Bifarcept
2032:Agonists:
1978:Agonists:
1910:Cilmostim
1907:Agonists:
1884:Namilumab
1841:Agonists:
1785:Agonists:
1674:Agonists:
1637:Chemokine
765:Drugs.com
732:Economics
134:Routes of
108:Pregnancy
56:Monograph
50:Drugs.com
2692:Medicine
2560:ZM-39923
2477:NSC-7908
2442:AZD-1480
2333:instead.
2313:instead.
2293:instead.
2269:instead.
2187:MEDI-545
1961:instead.
1889:Otilimab
1692:CNTO-530
1648:instead.
1250:20975064
1137:18360591
1059:32119434
999:DailyMed
952:(2021).
936:11308271
686:such as
418:(verify)
260:DrugBank
152:ATC code
123: B3
110:category
92:DailyMed
2502:SD-1008
1677:ARA-290
1241:2988667
1128:1661657
1004:7 April
927:2363901
826:29 June
771:7 April
672:DAHANCA
622:seizure
544:protein
509:Aranesp
353:Formula
269:DB00012
214:Rx-only
211:WARNING
168:)
162: (
160:B03XA02
94::
70:a604022
18:Aranesp
2678:Portal
2596:Others
2462:CYT387
2452:CHZ868
2341:Others
2097:IFNA21
2093:IFNA17
2089:IFNA16
2085:IFNA14
2081:IFNA13
2077:IFNA10
1304:8 June
1248:
1238:
1199:5 June
1167:5 June
1135:
1125:
1057:
934:
924:
616:, and
583:stroke
493:anemia
208:
195:
90:
2136:IFNB3
2132:IFNB1
2073:IFNA8
2069:IFNA7
2065:IFNA6
2061:IFNA5
2057:IFNA4
2053:IFNA2
2049:IFNA1
1577:Other
879:(PDF)
872:(PDF)
618:edema
612:and
595:tumor
575:death
505:Amgen
2575:TYK2
2517:JAK3
2429:JAK2
2366:JAK1
2331:here
2329:See
2311:here
2309:See
2302:TGFβ
2291:here
2289:See
2267:here
1959:here
1957:See
1646:here
1644:See
1306:2024
1280:2014
1246:PMID
1201:2007
1169:2007
1133:PMID
1086:2022
1055:PMID
1032:2007
1006:2020
932:PMID
887:2007
855:2007
828:2024
802:2023
773:2020
367:1317
296:UNII
287:none
46:AHFS
2349:JAK
2322:TNF
1657:CSF
1488:and
1351:B03
1236:PMC
1228:doi
1123:PMC
1113:doi
958:hdl
922:PMC
914:doi
795:FDA
651:on
444:ɑːr
432:INN
401:.19
399:396
379:241
373:233
361:815
321:EPA
165:WHO
2704::
2134:,
2095:,
2091:,
2087:,
2083:,
2079:,
2075:,
2071:,
2067:,
2063:,
2059:,
2055:,
2051:,
1297:.
1271:.
1244:.
1234:.
1224:28
1222:.
1218:.
1185:.
1153:.
1131:.
1121:.
1107:.
1103:.
1049:.
1023:.
997:.
986:^
972:^
930:.
920:.
910:84
908:.
904:.
818:.
793:.
789:.
763:.
750:^
624:,
601:.
589:,
585:,
581:,
577:,
553:.
546:.
511:.
459:oʊ
434:)
397:18
219:EU
204:US
197:S4
191:AU
143:,
119:AU
87:US
2680::
2357:)
2353:(
2138:)
2130:(
2099:)
2047:(
1618:e
1611:t
1604:v
1353:)
1349:(
1339:e
1332:t
1325:v
1308:.
1282:.
1230::
1203:.
1171:.
1139:.
1115::
1109:2
1088:.
1061:.
1034:.
1008:.
960::
938:.
916::
889:.
857:.
830:.
804:.
775:.
474:/
471:n
468:ɪ
465:t
462:ɪ
456:p
453:ˈ
450:ə
447:b
441:d
438:/
430:(
385:5
382:S
376:O
370:N
364:H
358:C
323:)
319:(
221::
206::
193::
121::
48:/
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
