35:
219:
InChI=1S/C34H60N14O12S/c1-17(49)43-20(8-11-25(51)52)29(57)47-22(9-12-26(53)54)31(59)48-23(13-16-61-2)32(60)46-21(7-10-24(35)50)30(58)45-19(6-4-15-42-34(39)40)28(56)44-18(27(36)55)5-3-14-41-33(37)38/h18-23H,3-16H2,1-2H3,(H2,35,50)(H2,36,55)(H,43,49)(H,44,56)(H,45,58)(H,46,60)(H,47,57)(H,48,59)(H,51,52)(H,53,54)(H4,37,38,41)(H4,39,40,42)/t18-,19-,20-,21-,22-,23-/m0/s1
131:
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460:(abnormal contraction or twitch of the eyelid), botulinum toxin injections with subsequent acetyl hexapeptide-3 treatment were compared to botulinum toxin injections with placebo cream treatment. Of the 12 patients in the acetyl hexapeptide-3 group, four experienced an extension of symptom control by 3.3 to 7.1 months.
468:
The 2012 study concluded there were no significant adverse effects. Patients receiving botulinum toxin injections exhibited longer times until return to baseline symptoms when supported with daily application of acetyl hexapeptide-8.
424:
Chemically, when applied as a solution to specific areas of the face, acetyl hexapeptide-8 inhibits the reactions that cause muscles to move or contract – for example when forming facial expressions such as smiling or frowning.
76:)-21-Acetamido-1-amino-12-(3-amino-3-oxopropyl)-6-carbamoyl-18-(2-carboxyethyl)-9-(3-guanidinopropyl)-1-imino-15-(2-(methylthio)ethyl)-8,11,14,17,20-pentaoxo-2,7,10,13,16,19-hexaazatetracosan-24-oic acid
360:
421:
Acetyl hexapeptide-8 is used in attempts to decrease the visible effects of aging by reducing the deep wrinkles and lines that occur around the forehead and eyes.
235:
560:
Ruiz, MA; Clares, B; Morales, ME; Cazalla, S; Gallardo, V (2007). "Preparation and stability of cosmetic formulations with an anti-aging peptide".
590:
Lungu, MD, Codrin; Considine, RN, Elaine; Zahir, MS, Sana; Ponsati, PhD, Berta; Arrastia, MS, Silvia; Hallet, MD, Mark (November 12, 2012).
210:
34:
592:"Pilot Study of Topical Acetyl Hexapeptide-8 in Treatment of Blepharospasm in Patients Receiving Botulinum Neurotoxin Therapy"
326:
367:
650:
187:
453:
525:
Blanes-Mira, C; et al. (October 2002). "A synthetic hexapeptide (Argireline) with antiwrinkle activity".
645:
243:
CSCC(NC(=O)(CCC(O)=O)NC(=O)(CCC(O)=O)NC(C)=O)C(=O)N(CCC(N)=O)C(=O)N(CCCNC(N)=N)C(=O)N(CCCNC(N)=N)C(N)=O
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386:(some sources incorrectly refer to this peptide as acetyl hexapeptide-3) is a synthetic
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Except where otherwise noted, data are given for materials in their
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445:(using a living organism) tests have been carried out, but no
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Acetyl hexapeptide-8 is the hexapeptide with the sequence
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8:
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26:
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409:). Acetyl hexapeptide-8 is marketed as
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222:Key: RJZNPROJTJSYLC-LLINQDLYSA-N
7:
449:anti-wrinkle studies are available.
166:
25:
456:trial investigating treatment of
539:10.1046/j.1467-2494.2002.00153.x
454:double-blind, placebo-controlled
439:(outside a living organism) and
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341:(at 25 °C , 100 kPa).
327:Stearamidopropyl dimethylamine
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1:
562:Journal of Cosmetic Science
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384:acetyl hexapeptide-8 amide
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417:Overview and common uses
397:which is a fragment of
28:Acetyl hexapeptide-3
393:ingredient. It is a
380:Acetyl hexapeptide-8
651:Cosmetics chemicals
411:Argireline® peptide
303: g·mol
79:Argireline® peptide
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368:Infobox references
308:Related compounds
27:
608:10.1111/ene.12009
401:, a substrate of
376:Chemical compound
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314:Related compounds
132:Interactive image
16:(Redirected from
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458:blepharospasm
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646:Hexapeptides
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596:Eur J Neurol
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388:anti-wrinkle
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91:Identifiers
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47:Other names
252:Properties
108:616204-22-9
640:Categories
505:References
452:In a 2012
322:Gusperimus
296:Molar mass
197:L4EL31FWIL
143:ChemSpider
119:3D model (
98:CAS Number
18:Argireline
473:Chemistry
391:cosmetics
626:23146065
574:17520155
547:18498523
436:in vitro
177:11228338
617:4747634
497:-Arg-NH
442:in vivo
429:Studies
399:SNAP-25
395:peptide
361:what is
359: (
164:PubChem
152:9403386
624:
614:
572:
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356:verify
353:
301:889.00
236:SMILES
42:Names
485:-Glu-
433:Both
407:Botox
211:InChI
121:JSmol
622:PMID
570:PMID
543:PMID
188:UNII
612:PMC
604:doi
535:doi
495:Arg
491:Gln
487:Met
483:Glu
382:or
167:CID
72:,21
68:,18
64:,15
60:,12
642::
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566:58
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513:^
501:.
479:Ac
286:12
280:14
274:60
268:34
56:,9
52:(6
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537::
499:2
493:-
489:-
481:-
405:(
351:N
289:S
283:O
277:N
271:H
265:C
123:)
74:S
70:S
66:S
62:S
58:S
54:S
20:)
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