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Arthur L. Horwich

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42: 339:, Heat shock protein 60, because it has a mass of 60 kDa and is produced in larger quantity in response to heat. Hsp60 is found in an 850 kDa double ring assembly, each ring containing 7 copies of Hsp60. Such assemblies, known as chaperonins, also exist in other cellular compartments and are essential components, mediating protein folding under both heat shock and normal conditions. 318:
In 1984, he moved across the hall from Rosenberg's lab to start his own laboratory as an assistant professor in the department of genetics. He still collaborated with members of the Rosenberg laboratory, including Wayne Fenton. As an independent researcher, Horwich asked whether the pathway that
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known as GroEL. They and others found early on that a chaperonin-mediated folding reaction can be reconstituted in a test tube, and that has enabled structural and functional studies that have begun to explain how chaperonins work.
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and witnessed Hunter's discovery of tyrosine phosphorylation. He credits this time with sharpening his skills as a scientist. He said, "Tony taught me the nuts and bolts of thinking about a problem."
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as part of a new program that combined the undergraduate degree with medical school. During medical school, Horwich studied fat cell metabolism in the laboratory of John Fain. Horwich received his
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of mammalian cells also could work in yeast. In 1987, during a genetic screen in yeast, Horwich and his colleagues stumbled across a protein folding function inside
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in 1975. He graduated as valedictorian of the first class to complete the combined program. Horwich went on to do an internship and residency in pediatrics at
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Cheng, M.Y.; Hartl, F.U.; Martin, J.; Pollock, R. A.; Kalousek, F.; Neupert, W.; Hallberg, E. M.; Hallberg, R. L. & Horwich, A. L. (February 16, 1989).
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for a postdoctoral position in molecular biology and virology. At Salk, he worked in Walter Eckhart's laboratory alongside
1229: 2221: 1650: 412: 287:. Midway through, Horwich was not sure about an entirely clinical future. After completing his residency, he joined the 252: 968: 453: 244: 119: 885:"Import and processing of human ornithine transcarbamoylase precursor by mitochondria from Saccharomyces cerevisiae" 1510: 1494: 401: 320: 232: 107: 41: 1163: 2167: 2051: 1329: 607:"Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria" 512:"Tapan K. Chahudhuri- Chaperone Mediated Protein Folding, Protein Engineering and Molecular Biophysics Group" 1747: 1588: 422: 209: 169: 661: 2279: 308: 224:, protein complexes that assist the folding of other proteins; Horwich first published this work in 1989. 1451: 1989: 2249: 2077: 2013: 1470: 896: 618: 292: 2057: 2045: 2173: 2151: 2089: 2067: 2023: 1813: 1751: 1524: 1421: 405: 1955: 1105: 2215: 2199: 1995: 1823: 1550: 1520: 1373: 1315: 642: 388: 280: 268: 205: 1791: 1626: 1083: 335:
normally but then misfolded and aggregated. They named the protein encoded by the affected gene
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Cheng, M.Y.; Pollock, R.A.; Hendrick, J. P. & Horwich, A. L. (June 15, 1987).
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Since 1987, Horwich and his colleagues have been studying these molecules both in
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Recipients of the Albert Lasker Award for Basic Medical Research
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Arthur Horwich Seminars: "Chaperone-Assisted Protein Folding"
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Members of the United States National Academy of Sciences
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For his scientific work Horwich has been awarded the
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2006: Stein and Moore Award (Protein Society Award)
183: 162: 152: 82: 74: 64: 56: 48: 32: 1187:BBVA Foundation Frontiers of Knowledge Award 2023 315:. He worked in the laboratory of Leon Rosenberg. 364:2001: Hans Neurath Award (Protein Society Award) 826:Proceedings of the National Academy of Sciences 731:Proceedings of the National Academy of Sciences 523: 521: 466:Dr. Paul Janssen Award for Biomedical Research 433:Albert Lasker Award for Basic Medical Research 1881: 1237: 445:2014: Honorary Doctorate of Medical Science, 206:Sterling Professor of Genetics and Pediatrics 8: 492:BBVA Foundation Frontiers of Knowledge Award 136:BBVA Foundation Frontiers of Knowledge Award 2310:Members of the National Academy of Medicine 216:investigator since 1990. His research into 1888: 1874: 1866: 1244: 1230: 1222: 1164:"Nakasone Prize Won By Arthur Horwich, MD" 460:Paul Ehrlich and Ludwig Darmstaedter Prize 40: 29: 971:. The Gairdner Foundation. Archived from 918: 908: 847: 837: 760: 742: 557:. Yale School of Medicine. Archived from 531:. Yale School of Medicine. Archived from 1151:Breakthrough Prize in Life Sciences 2020 267:Horwich was born in 1951. He grew up in 503: 279:in biomedical sciences in 1972 and his 271:, west of Chicago. In 1969, he entered 90:Gairdner Foundation International Award 1106:"Brown confers nine honorary degrees" 1049:. Brandeis University. Archived from 997:. The Protein Society. Archived from 945:. The Protein Society. Archived from 479:American Academy of Arts and Sciences 289:Salk Institute for Biological Studies 257:American Academy of Arts and Sciences 7: 2265:Howard Hughes Medical Investigators 1212:Chaperonin-Mediated Protein Folding 473:Breakthrough Prize in Life Sciences 376:Canada Gairdner International Award 313:Yale University School of Medicine 25: 586:. Howard Hughes Medical Institute 427:University of Southern California 311:for a postdoctoral fellowship at 2305:21st-century American biologists 1108:. Brown University. May 25, 2014 822:"Biography of Arthur L. Horwich" 727:"Biography of Arthur L. Horwich" 725:Davis, Tinsley H. (2004-10-19). 2270:Yale School of Medicine faculty 1084:"2011 Lasker Award Description" 1072:Louisa Gross Horwitz Prize 2008 662:"The Nobel Prize Will Go To..." 660:Wang, Shirley S. (2009-09-14). 307:In 1981, Horwich moved back to 214:Howard Hughes Medical Institute 175:Howard Hughes Medical Institute 784:Hahamy, Madison (2021-05-04). 485:Human Frontier Science Program 251:(2020). He is a member of the 27:American biologist (born 1951) 1: 1207:Interview with Arthur Horwich 404:for Biology or Biochemistry, 2300:Alpert Medical School alumni 2222:Jennifer Lippincott-Schwartz 468:, awarded jointly with Hartl 442:, awarded jointly with Hartl 435:, awarded jointly with Hartl 413:National Academy of Medicine 408:; awarded jointly with Hartl 397:, awarded jointly with Hartl 369:National Academy of Sciences 253:National Academy of Sciences 229:Gairdner International Award 78:uncovering chaperonin action 692:Zimmer, Carl (2011-09-12). 454:Albany Medical Center Prize 245:Albany Medical Center Prize 200:(born 1951) is an American 52:1951 (age 72–73) 2326: 402:Louisa Gross Horwitz Prize 321:ornithine transcarbamylase 233:Louisa Gross Horwitz Prize 212:. Horwich has also been a 108:Louisa Gross Horwitz Prize 820:Tinsley H. Davis (2004). 319:imports an enzyme called 191: 145: 39: 2290:Yale Sterling Professors 1128:"Dr. Paul Janssen Award" 584:"Arthur L. Horwich, M.D" 555:"Form leads to function" 220:uncovered the action of 2295:Massry Prize recipients 2275:Yale University faculty 2260:Brown University alumni 1748:Demetrios Christodoulou 1589:Everett Peter Greenberg 1202:Art Horwich Lab at Yale 1086:. The Lasker Foundation 910:10.1073/pnas.84.12.4063 839:10.1073/pnas.0406924101 744:10.1073/pnas.0406924101 423:Keck School of Medicine 387:, awarded jointly with 210:Yale School of Medicine 170:Yale School of Medicine 1132:Dr. Paul Janssen Award 309:New Haven, Connecticut 1452:Shrinivas R. Kulkarni 477:2021: Elected to the 411:2008: Elected to the 367:2003: Elected to the 2078:Alexander Varshavsky 1511:Keith H. S. Campbell 1471:Stanley Norman Cohen 1047:"Award Winners 2008" 975:on December 14, 2007 293:La Jolla, California 2174:William R. Brinkley 2152:J. Richard McIntosh 2068:Elizabeth Blackburn 1814:Alexander Beilinson 1752:Richard S. Hamilton 1422:Chryssa Kouveliotou 1162:Backman, Isabella. 901:1987PNAS...84.4063C 832:(42): 15002–15004. 737:(42): 15002–15004. 665:Wall Street Journal 623:1989Natur.337..620C 529:"Arthur L. Horwich" 406:Columbia University 2216:Peter N. Devreotes 2200:Franz-Ulrich Hartl 1996:S. Jonathan Singer 1824:Jean-Michel Bismut 1551:Franz-Ulrich Hartl 1374:William J. Borucki 1053:on August 20, 2007 1027:on August 13, 2007 698:The New York Times 389:Franz-Ulrich Hartl 249:Breakthrough Prize 187:Tapan K. Chaudhuri 132:Breakthrough Prize 2237: 2236: 2228:Pietro De Camilli 2090:Thomas D. Pollard 1984:Christian de Duve 1966:David D. Sabatini 1897:E.B. Wilson Medal 1863: 1862: 1844:Vladimir Drinfeld 1690:Shiing-Shen Chern 1647:Paul A. Negulescu 1555:Arthur L. Horwich 1428:Lennart Lindegren 1360:Daniel Eisenstein 1168:medicine.yale.edu 995:"Past Recipients" 943:"Past Recipients" 895:(12): 4063–4067. 617:(6208): 620–625. 359:Awards and honors 198:Arthur L. Horwich 195: 194: 147:Scientific career 34:Arthur L. Horwich 16:(Redirected from 2317: 2210:Barbara J. Meyer 2108:Richard O. Hynes 2062:Gottfried Schatz 2042:James E. Darnell 1990:Morris Karnovsky 1972:Marilyn Farquhar 1930:Alex B. Novikoff 1890: 1883: 1876: 1867: 1808:Michel Talagrand 1758:Maxim Kontsevich 1712:Robert Langlands 1651:Michael J. Welsh 1615:Mary-Claire King 1569:Michael W. Young 1541:Ruslan Medzhitov 1525:Jeffrey Friedman 1501:Robert Lefkowitz 1489:Michael Berridge 1446:Maura McLaughlin 1432:Michael Perryman 1246: 1239: 1232: 1223: 1189: 1184: 1178: 1177: 1175: 1174: 1159: 1153: 1148: 1142: 1141: 1139: 1138: 1124: 1118: 1117: 1115: 1113: 1102: 1096: 1095: 1093: 1091: 1080: 1074: 1069: 1063: 1062: 1060: 1058: 1043: 1037: 1036: 1034: 1032: 1017: 1011: 1010: 1008: 1006: 991: 985: 984: 982: 980: 965: 959: 958: 956: 954: 939: 933: 932: 922: 912: 880: 874: 868: 862: 861: 851: 841: 817: 800: 799: 797: 796: 781: 775: 774: 764: 746: 722: 716: 715: 713: 712: 689: 683: 682: 680: 679: 657: 651: 650: 631:10.1038/337620a0 602: 596: 595: 593: 591: 580: 571: 570: 568: 566: 551: 545: 544: 542: 540: 525: 516: 515: 508: 447:Brown University 395:Rosenstiel Award 273:Brown University 184:Notable students 102:Rosenstiel Award 69:Brown University 44: 30: 21: 2325: 2324: 2320: 2319: 2318: 2316: 2315: 2314: 2240: 2239: 2238: 2233: 2188:Elaine V. Fuchs 2168:John R. 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Jewitt 1316:Charles Bennett 1304:Reinhard Genzel 1298:Peter Goldreich 1284:Saul Perlmutter 1256: 1250: 1198: 1193: 1192: 1185: 1181: 1172: 1170: 1161: 1160: 1156: 1149: 1145: 1136: 1134: 1126: 1125: 1121: 1111: 1109: 1104: 1103: 1099: 1089: 1087: 1082: 1081: 1077: 1070: 1066: 1056: 1054: 1045: 1044: 1040: 1030: 1028: 1019: 1018: 1014: 1004: 1002: 1001:on May 13, 2008 993: 992: 988: 978: 976: 967: 966: 962: 952: 950: 949:on May 13, 2008 941: 940: 936: 882: 881: 877: 869: 865: 819: 818: 803: 794: 792: 790:Yale Daily News 783: 782: 778: 724: 723: 719: 710: 708: 691: 690: 686: 677: 675: 659: 658: 654: 604: 603: 599: 589: 587: 582: 581: 574: 564: 562: 561:on May 21, 2008 553: 552: 548: 538: 536: 535:on May 30, 2008 527: 526: 519: 510: 509: 505: 500: 361: 323:(OTC) into the 305: 285:Yale University 265: 218:protein folding 179: 141: 65:Alma mater 35: 28: 23: 22: 15: 12: 11: 5: 2323: 2321: 2313: 2312: 2307: 2302: 2297: 2292: 2287: 2282: 2277: 2272: 2267: 2262: 2257: 2252: 2242: 2241: 2235: 2234: 2232: 2231: 2225: 2219: 2213: 2207: 2204:Arthur Horwich 2197: 2191: 2185: 2178:John E. 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Hawley 1347: 1337: 1334:Gerald Fishman 1327: 1313: 1307: 1301: 1295: 1281: 1274:Geoffrey Marcy 1271: 1264: 1262: 1258: 1257: 1251: 1249: 1248: 1241: 1234: 1226: 1220: 1219: 1214: 1209: 1204: 1197: 1196:External links 1194: 1191: 1190: 1179: 1154: 1143: 1119: 1097: 1075: 1064: 1038: 1012: 986: 969:"2004 winners" 960: 934: 875: 863: 801: 776: 717: 684: 652: 597: 572: 546: 517: 502: 501: 499: 496: 495: 494: 488: 487:Nakasone Award 481: 475: 469: 462: 456: 450: 443: 436: 429: 415: 409: 398: 391: 381: 378: 372: 365: 360: 357: 304: 301: 264: 261: 193: 192: 189: 188: 185: 181: 180: 178: 177: 172: 166: 164: 160: 159: 154: 150: 149: 143: 142: 140: 139: 129: 123: 117: 111: 105: 99: 93: 86: 84: 80: 79: 76: 75:Known for 72: 71: 66: 62: 61: 58: 54: 53: 50: 46: 45: 37: 36: 33: 26: 24: 18:Arthur Horwich 14: 13: 10: 9: 6: 4: 3: 2: 2322: 2311: 2308: 2306: 2303: 2301: 2298: 2296: 2293: 2291: 2288: 2286: 2283: 2281: 2280:Living people 2278: 2276: 2273: 2271: 2268: 2266: 2263: 2261: 2258: 2256: 2253: 2251: 2248: 2247: 2245: 2229: 2226: 2223: 2220: 2217: 2214: 2211: 2208: 2205: 2201: 2198: 2195: 2192: 2189: 2186: 2183: 2179: 2175: 2172: 2169: 2166: 2163: 2160: 2157: 2156:James Spudich 2153: 2149: 2146: 2143: 2139: 2138:James Rothman 2135: 2132: 2129: 2126: 2123: 2119: 2116: 2113: 2109: 2106: 2103: 2100: 2097: 2094: 2091: 2088: 2085: 2082: 2079: 2075: 2074:Avram Hershko 2072: 2069: 2066: 2063: 2059: 2056: 2053: 2050: 2047: 2043: 2040: 2037: 2034: 2031: 2028: 2025: 2024:Bruce Nicklas 2022: 2019: 2015: 2012: 2009: 2006: 2003: 2000: 1997: 1994: 1991: 1988: 1985: 1982: 1979: 1978:Elizabeth Hay 1976: 1973: 1970: 1967: 1963: 1962:Gunter Blobel 1960: 1957: 1954: 1951: 1950:Theodore Puck 1947: 1944: 1941: 1937: 1934: 1931: 1927: 1924: 1921: 1917: 1916:George Palade 1913: 1910: 1909: 1907: 1903: 1898: 1891: 1886: 1884: 1879: 1877: 1872: 1871: 1868: 1855: 1852: 1849: 1845: 1842: 1839: 1835: 1832: 1829: 1825: 1822: 1819: 1818:David Kazhdan 1815: 1812: 1809: 1806: 1803: 1800: 1797: 1796:Claire Voisin 1793: 1790: 1787: 1786:Nigel Hitchin 1784: 1781: 1777: 1776:Gerd Faltings 1774: 1771: 1768: 1765: 1762: 1759: 1756: 1753: 1749: 1746: 1743: 1742:Jean Bourgain 1740: 1737: 1733: 1730: 1727: 1723: 1720: 1717: 1713: 1710: 1707: 1703: 1702:David Mumford 1700: 1697: 1694: 1691: 1688: 1687: 1685: 1679: 1672: 1668: 1665: 1662: 1658: 1655: 1652: 1648: 1645: 1642: 1639: 1636: 1632: 1628: 1625: 1622: 1619: 1616: 1613: 1610: 1606: 1603: 1600: 1596: 1593: 1590: 1586: 1583: 1580: 1576: 1573: 1570: 1566: 1562: 1559: 1556: 1552: 1549: 1546: 1545:Bruce Beutler 1542: 1538: 1535: 1532: 1529: 1526: 1522: 1519: 1516: 1512: 1508: 1505: 1502: 1499: 1496: 1495:Xiaodong Wang 1493: 1490: 1487: 1484: 1480: 1476: 1475:Herbert Boyer 1472: 1469: 1468: 1466: 1460: 1453: 1450: 1447: 1443: 1439: 1436: 1433: 1429: 1426: 1423: 1419: 1416: 1413: 1410: 1407: 1404: 1401: 1398: 1395: 1392: 1389: 1385: 1381: 1380:Ronald Drever 1378: 1375: 1372: 1369: 1365: 1361: 1358: 1355: 1351: 1350:Steven Balbus 1348: 1345: 1341: 1338: 1335: 1331: 1328: 1325: 1324:David Spergel 1321: 1317: 1314: 1311: 1308: 1305: 1302: 1299: 1296: 1293: 1292:Brian Schmidt 1289: 1285: 1282: 1279: 1275: 1272: 1269: 1266: 1265: 1263: 1259: 1254: 1247: 1242: 1240: 1235: 1233: 1228: 1227: 1224: 1218: 1215: 1213: 1210: 1208: 1205: 1203: 1200: 1199: 1195: 1188: 1183: 1180: 1169: 1165: 1158: 1155: 1152: 1147: 1144: 1133: 1129: 1123: 1120: 1107: 1101: 1098: 1090:September 12, 1085: 1079: 1076: 1073: 1068: 1065: 1052: 1048: 1042: 1039: 1026: 1022: 1016: 1013: 1000: 996: 990: 987: 974: 970: 964: 961: 948: 944: 938: 935: 930: 926: 921: 916: 911: 906: 902: 898: 894: 890: 886: 879: 876: 872: 867: 864: 859: 855: 850: 845: 840: 835: 831: 827: 823: 816: 814: 812: 810: 808: 806: 802: 791: 787: 780: 777: 772: 768: 763: 758: 754: 750: 745: 740: 736: 732: 728: 721: 718: 707: 703: 699: 695: 688: 685: 674: 670: 666: 663: 656: 653: 648: 644: 640: 636: 632: 628: 624: 620: 616: 612: 608: 601: 598: 585: 579: 577: 573: 560: 556: 550: 547: 534: 530: 524: 522: 518: 513: 507: 504: 497: 493: 489: 486: 482: 480: 476: 474: 470: 467: 463: 461: 457: 455: 451: 448: 444: 441: 437: 434: 430: 428: 424: 420: 416: 414: 410: 407: 403: 399: 396: 392: 390: 386: 382: 379: 377: 373: 370: 366: 363: 362: 358: 356: 353: 349: 345: 340: 338: 334: 330: 326: 322: 316: 314: 310: 302: 300: 298: 294: 290: 286: 282: 278: 274: 270: 262: 260: 258: 254: 250: 246: 242: 238: 234: 230: 225: 223: 219: 215: 211: 207: 203: 199: 190: 186: 182: 176: 173: 171: 168: 167: 165: 161: 158: 155: 151: 148: 144: 137: 133: 130: 127: 124: 121: 118: 115: 112: 109: 106: 103: 100: 97: 94: 91: 88: 87: 85: 81: 77: 73: 70: 67: 63: 59: 55: 51: 47: 43: 38: 31: 19: 2194:Mina Bissell 2128:Peter Walter 2052:Edwin Taylor 2002:Shinya Inoue 1956:Hewson Swift 1920:Keith Porter 1912:Daniel Mazia 1854:Peter Sarnak 1828:Jeff Cheeger 1792:János Kollár 1764:David Donoho 1696:Andrew Wiles 1681:Mathematical 1641:Scott D. Emr 1579:Peter Walter 1554: 1531:David Julius 1483:Richard Doll 1479:Yuet-Wai Kan 1464:and medicine 1462:Life science 1388:Rainer Weiss 1330:Enrico Costa 1278:Michel Mayor 1182: 1171:. Retrieved 1167: 1157: 1146: 1135:. Retrieved 1131: 1122: 1110:. Retrieved 1100: 1088:. Retrieved 1078: 1067: 1055:. Retrieved 1051:the original 1041: 1029:. Retrieved 1025:the original 1015: 1003:. Retrieved 999:the original 989: 977:. Retrieved 973:the original 963: 951:. Retrieved 947:the original 937: 892: 888: 878: 866: 829: 825: 793:. Retrieved 789: 779: 734: 730: 720: 709:. Retrieved 697: 687: 676:. Retrieved 664: 655: 614: 610: 600: 588:. Retrieved 563:. Retrieved 559:the original 549: 537:. 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Yale 856:  849:524080 846:  769:  762:524080 759:  751:  704:  671:  645:  637:  611:Nature 490:2023: 483:2022: 471:2020: 464:2019: 458:2019: 452:2016: 438:2012: 431:2011: 417:2011: 400:2008: 393:2008: 383:2007: 374:2004: 153:Fields 138:(2023) 128:(2012) 122:(2016) 116:(2011) 110:(2008) 104:(2008) 98:(2007) 92:(2004) 83:Awards 643:S2CID 337:HSP60 2202:and 2180:and 2120:and 2110:and 2076:and 2060:and 2044:and 2016:and 1964:and 1948:and 1938:and 1928:and 1918:and 1846:and 1836:and 1826:and 1816:and 1794:and 1778:and 1750:and 1734:and 1724:and 1714:and 1704:and 1669:and 1659:and 1649:and 1633:and 1607:and 1597:and 1587:and 1577:and 1567:and 1553:and 1543:and 1523:and 1513:and 1481:and 1444:and 1430:and 1420:and 1386:and 1366:and 1352:and 1342:and 1332:and 1322:and 1290:and 1276:and 1114:2014 1092:2011 1059:2008 1033:2008 1007:2008 981:2008 955:2008 925:PMID 889:PNAS 854:PMID 767:PMID 749:ISSN 702:ISSN 669:ISSN 635:PMID 592:2008 567:2008 541:2008 346:and 344:vivo 281:M.D. 277:A.B. 204:and 49:Born 915:PMC 905:doi 844:PMC 834:doi 830:101 757:PMC 739:doi 735:101 627:doi 615:337 291:in 2246:: 2176:, 2150:, 2136:, 1914:, 1629:, 1563:, 1539:, 1509:, 1477:, 1473:, 1440:, 1382:, 1362:, 1318:, 1286:, 1166:. 1130:. 923:. 913:. 903:. 893:84 891:. 887:. 852:. 842:. 828:. 824:. 804:^ 788:. 765:. 755:. 747:. 733:. 729:. 700:. 696:. 667:. 641:. 633:. 625:. 613:. 609:. 575:^ 520:^ 425:, 421:, 259:. 1889:e 1882:t 1875:v 1245:e 1238:t 1231:v 1176:. 1140:. 1116:. 1094:. 1061:. 1035:. 1009:. 983:. 957:. 931:. 907:: 899:: 860:. 836:: 798:. 773:. 741:: 714:. 681:. 649:. 629:: 621:: 594:. 569:. 543:. 514:. 449:. 371:. 20:)

Index

Arthur Horwich

Brown University
Gairdner Foundation International Award
Wiley Prize
Rosenstiel Award
Louisa Gross Horwitz Prize
Lasker Award
Albany Prize
Shaw Prize
Breakthrough Prize
BBVA Foundation Frontiers of Knowledge Award
Biology
Yale School of Medicine
Howard Hughes Medical Institute
biologist
Sterling Professor of Genetics and Pediatrics
Yale School of Medicine
Howard Hughes Medical Institute
protein folding
chaperonins
Gairdner International Award
Louisa Gross Horwitz Prize
Lasker Award
Shaw Prize
Albany Medical Center Prize
Breakthrough Prize
National Academy of Sciences
American Academy of Arts and Sciences
Oak Park

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