42:
339:, Heat shock protein 60, because it has a mass of 60 kDa and is produced in larger quantity in response to heat. Hsp60 is found in an 850 kDa double ring assembly, each ring containing 7 copies of Hsp60. Such assemblies, known as chaperonins, also exist in other cellular compartments and are essential components, mediating protein folding under both heat shock and normal conditions.
318:
In 1984, he moved across the hall from
Rosenberg's lab to start his own laboratory as an assistant professor in the department of genetics. He still collaborated with members of the Rosenberg laboratory, including Wayne Fenton. As an independent researcher, Horwich asked whether the pathway that
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known as GroEL. They and others found early on that a chaperonin-mediated folding reaction can be reconstituted in a test tube, and that has enabled structural and functional studies that have begun to explain how chaperonins work.
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and witnessed Hunter's discovery of tyrosine phosphorylation. He credits this time with sharpening his skills as a scientist. He said, "Tony taught me the nuts and bolts of thinking about a problem."
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as part of a new program that combined the undergraduate degree with medical school. During medical school, Horwich studied fat cell metabolism in the laboratory of John Fain. Horwich received his
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of mammalian cells also could work in yeast. In 1987, during a genetic screen in yeast, Horwich and his colleagues stumbled across a protein folding function inside
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in 1975. He graduated as valedictorian of the first class to complete the combined program. Horwich went on to do an internship and residency in pediatrics at
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Cheng, M.Y.; Hartl, F.U.; Martin, J.; Pollock, R. A.; Kalousek, F.; Neupert, W.; Hallberg, E. M.; Hallberg, R. L. & Horwich, A. L. (February 16, 1989).
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for a postdoctoral position in molecular biology and virology. At Salk, he worked in Walter
Eckhart's laboratory alongside
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287:. Midway through, Horwich was not sure about an entirely clinical future. After completing his residency, he joined the
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885:"Import and processing of human ornithine transcarbamoylase precursor by mitochondria from Saccharomyces cerevisiae"
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607:"Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria"
512:"Tapan K. Chahudhuri- Chaperone Mediated Protein Folding, Protein Engineering and Molecular Biophysics Group"
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normally but then misfolded and aggregated. They named the protein encoded by the affected gene
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1021:"Recipients Of 6th Annual Wiley Prize In Biomedical Sciences Announced By Wiley Foundation"
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Cheng, M.Y.; Pollock, R.A.; Hendrick, J. P. & Horwich, A. L. (June 15, 1987).
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Since 1987, Horwich and his colleagues have been studying these molecules both in
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Recipients of the Albert Lasker Award for Basic
Medical Research
871:"Horwich is Higgins Professor of Cellular, Molecular Physiology"
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331:. In the mutant strain, proteins entered mitochondria from the
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694:"Horwich Wins Lasker Award by Straddling Science and Medicine"
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Arthur
Horwich Seminars: "Chaperone-Assisted Protein Folding"
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Members of the United States
National Academy of Sciences
578:
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1023:. Medical News Today. February 2, 2007. Archived from
350:, with particular emphasis on the Hsp60 homologue in
227:
For his scientific work
Horwich has been awarded the
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2006: Stein and Moore Award (Protein
Society Award)
183:
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82:
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32:
1187:BBVA Foundation Frontiers of Knowledge Award 2023
315:. He worked in the laboratory of Leon Rosenberg.
364:2001: Hans Neurath Award (Protein Society Award)
826:Proceedings of the National Academy of Sciences
731:Proceedings of the National Academy of Sciences
523:
521:
466:Dr. Paul Janssen Award for Biomedical Research
433:Albert Lasker Award for Basic Medical Research
1881:
1237:
445:2014: Honorary Doctorate of Medical Science,
206:Sterling Professor of Genetics and Pediatrics
8:
492:BBVA Foundation Frontiers of Knowledge Award
136:BBVA Foundation Frontiers of Knowledge Award
2310:Members of the National Academy of Medicine
216:investigator since 1990. His research into
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1164:"Nakasone Prize Won By Arthur Horwich, MD"
460:Paul Ehrlich and Ludwig Darmstaedter Prize
40:
29:
971:. The Gairdner Foundation. Archived from
918:
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557:. Yale School of Medicine. Archived from
531:. Yale School of Medicine. Archived from
1151:Breakthrough Prize in Life Sciences 2020
267:Horwich was born in 1951. He grew up in
503:
279:in biomedical sciences in 1972 and his
271:, west of Chicago. In 1969, he entered
90:Gairdner Foundation International Award
1106:"Brown confers nine honorary degrees"
1049:. Brandeis University. Archived from
997:. The Protein Society. Archived from
945:. The Protein Society. Archived from
479:American Academy of Arts and Sciences
289:Salk Institute for Biological Studies
257:American Academy of Arts and Sciences
7:
2265:Howard Hughes Medical Investigators
1212:Chaperonin-Mediated Protein Folding
473:Breakthrough Prize in Life Sciences
376:Canada Gairdner International Award
313:Yale University School of Medicine
25:
586:. Howard Hughes Medical Institute
427:University of Southern California
311:for a postdoctoral fellowship at
2305:21st-century American biologists
1108:. Brown University. May 25, 2014
822:"Biography of Arthur L. Horwich"
727:"Biography of Arthur L. Horwich"
725:Davis, Tinsley H. (2004-10-19).
2270:Yale School of Medicine faculty
1084:"2011 Lasker Award Description"
1072:Louisa Gross Horwitz Prize 2008
662:"The Nobel Prize Will Go To..."
660:Wang, Shirley S. (2009-09-14).
307:In 1981, Horwich moved back to
214:Howard Hughes Medical Institute
175:Howard Hughes Medical Institute
784:Hahamy, Madison (2021-05-04).
485:Human Frontier Science Program
251:(2020). He is a member of the
27:American biologist (born 1951)
1:
1207:Interview with Arthur Horwich
404:for Biology or Biochemistry,
2300:Alpert Medical School alumni
2222:Jennifer Lippincott-Schwartz
468:, awarded jointly with Hartl
442:, awarded jointly with Hartl
435:, awarded jointly with Hartl
413:National Academy of Medicine
408:; awarded jointly with Hartl
397:, awarded jointly with Hartl
369:National Academy of Sciences
253:National Academy of Sciences
229:Gairdner International Award
78:uncovering chaperonin action
692:Zimmer, Carl (2011-09-12).
454:Albany Medical Center Prize
245:Albany Medical Center Prize
200:(born 1951) is an American
52:1951 (age 72–73)
2326:
402:Louisa Gross Horwitz Prize
321:ornithine transcarbamylase
233:Louisa Gross Horwitz Prize
212:. Horwich has also been a
108:Louisa Gross Horwitz Prize
820:Tinsley H. Davis (2004).
319:imports an enzyme called
191:
145:
39:
2290:Yale Sterling Professors
1128:"Dr. Paul Janssen Award"
584:"Arthur L. Horwich, M.D"
555:"Form leads to function"
220:uncovered the action of
2295:Massry Prize recipients
2275:Yale University faculty
2260:Brown University alumni
1748:Demetrios Christodoulou
1589:Everett Peter Greenberg
1202:Art Horwich Lab at Yale
1086:. The Lasker Foundation
910:10.1073/pnas.84.12.4063
839:10.1073/pnas.0406924101
744:10.1073/pnas.0406924101
423:Keck School of Medicine
387:, awarded jointly with
210:Yale School of Medicine
170:Yale School of Medicine
1132:Dr. Paul Janssen Award
309:New Haven, Connecticut
1452:Shrinivas R. Kulkarni
477:2021: Elected to the
411:2008: Elected to the
367:2003: Elected to the
2078:Alexander Varshavsky
1511:Keith H. S. Campbell
1471:Stanley Norman Cohen
1047:"Award Winners 2008"
975:on December 14, 2007
293:La Jolla, California
2174:William R. Brinkley
2152:J. Richard McIntosh
2068:Elizabeth Blackburn
1814:Alexander Beilinson
1752:Richard S. Hamilton
1422:Chryssa Kouveliotou
1162:Backman, Isabella.
901:1987PNAS...84.4063C
832:(42): 15002–15004.
737:(42): 15002–15004.
665:Wall Street Journal
623:1989Natur.337..620C
529:"Arthur L. Horwich"
406:Columbia University
2216:Peter N. Devreotes
2200:Franz-Ulrich Hartl
1996:S. Jonathan Singer
1824:Jean-Michel Bismut
1551:Franz-Ulrich Hartl
1374:William J. Borucki
1053:on August 20, 2007
1027:on August 13, 2007
698:The New York Times
389:Franz-Ulrich Hartl
249:Breakthrough Prize
187:Tapan K. Chaudhuri
132:Breakthrough Prize
2237:
2236:
2228:Pietro De Camilli
2090:Thomas D. Pollard
1984:Christian de Duve
1966:David D. Sabatini
1897:E.B. Wilson Medal
1863:
1862:
1844:Vladimir Drinfeld
1690:Shiing-Shen Chern
1647:Paul A. Negulescu
1555:Arthur L. Horwich
1428:Lennart Lindegren
1360:Daniel Eisenstein
1168:medicine.yale.edu
995:"Past Recipients"
943:"Past Recipients"
895:(12): 4063–4067.
617:(6208): 620–625.
359:Awards and honors
198:Arthur L. Horwich
195:
194:
147:Scientific career
34:Arthur L. Horwich
16:(Redirected from
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2210:Barbara J. Meyer
2108:Richard O. Hynes
2062:Gottfried Schatz
2042:James E. Darnell
1990:Morris Karnovsky
1972:Marilyn Farquhar
1930:Alex B. Novikoff
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1808:Michel Talagrand
1758:Maxim Kontsevich
1712:Robert Langlands
1651:Michael J. Welsh
1615:Mary-Claire King
1569:Michael W. Young
1541:Ruslan Medzhitov
1525:Jeffrey Friedman
1501:Robert Lefkowitz
1489:Michael Berridge
1446:Maura McLaughlin
1432:Michael Perryman
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447:Brown University
395:Rosenstiel Award
273:Brown University
184:Notable students
102:Rosenstiel Award
69:Brown University
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2030:Donald D. Brown
2014:Barbara Gibbons
1926:Charles Leblond
1900:
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1802:Luis Caffarelli
1736:Clifford Taubes
1732:Simon Donaldson
1722:Vladimir Arnold
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1667:Stuart H. Orkin
1627:Gero Miesenböck
1565:Michael Rosbash
1561:Jeffrey C. Hall
1521:Douglas Coleman
1515:Shinya Yamanaka
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1457:
1412:Roger Blandford
1406:Edward C. Stone
1400:Jean-Loup Puget
1368:John A. Peacock
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1304:Reinhard Genzel
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1284:Saul Perlmutter
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323:(OTC) into the
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285:Yale University
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218:protein folding
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1956:Hewson Swift
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1912:Daniel Mazia
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1828:Jeff Cheeger
1792:János Kollár
1764:David Donoho
1696:Andrew Wiles
1681:Mathematical
1641:Scott D. Emr
1579:Peter Walter
1554:
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1483:Richard Doll
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1464:and medicine
1462:Life science
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329:mitochondria
325:mitochondria
317:
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226:
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163:Institutions
146:
120:Albany Prize
114:Lasker Award
2250:1951 births
2182:Peter Satir
2148:Gary Borisy
2122:Roger Tsien
1946:Harry Eagle
1940:Hugh Huxley
1936:Joseph Gall
1661:Eva Nogales
1635:Georg Nagel
1621:Maria Jasin
1609:Ronald Vale
1599:Huda Zoghbi
1595:Adrian Bird
1394:Simon White
1268:Jim Peebles
1057:February 1,
1031:January 24,
1005:February 1,
979:January 24,
953:February 1,
590:January 24,
565:January 24,
385:Wiley Prize
297:Tony Hunter
263:Early years
222:chaperonins
96:Wiley Prize
57:Nationality
2244:Categories
1905:Recipients
1899:recipients
1706:Wentsun Wu
1507:Ian Wilmut
1384:Kip Thorne
1364:Shaun Cole
1320:Lyman Page
1288:Adam Riess
1253:Shaw Prize
1173:2022-02-11
1137:2022-02-11
795:2022-02-11
711:2022-02-11
678:2022-02-11
498:References
440:Shaw Prize
241:Shaw Prize
126:Shaw Prize
2112:Zena Werb
1834:Noga Alon
1310:Frank Shu
1261:Astronomy
1255:laureates
753:0027-8424
706:0362-4331
673:0099-9660
539:March 18,
202:biologist
2008:Hans Ris
1344:Jane Luu
858:15479759
771:15479759
348:in vitro
303:Research
269:Oak Park
255:and the
243:(2012),
239:(2011),
235:(2008),
231:(2004),
60:American
1683:science
1112:May 27,
929:3295876
897:Bibcode
647:4333381
639:2645524
619:Bibcode
352:E. coli
333:cytosol
208:at the
157:Biology
134:(2020)
2230:(2021)
2224:(2020)
2218:(2019)
2212:(2018)
2206:(2017)
2196:(2016)
2190:(2015)
2184:(2014)
2170:(2013)
2164:(2012)
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2098:(2005)
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2086:(2003)
2080:(2002)
2070:(2001)
2064:(2000)
2054:(1999)
2048:(1998)
2038:(1997)
2032:(1996)
2026:(1995)
2020:(1994)
2010:(1993)
2004:(1992)
1998:(1991)
1992:(1990)
1986:(1989)
1980:(1988)
1974:(1987)
1968:(1986)
1958:(1985)
1952:(1984)
1942:(1983)
1932:(1982)
1922:(1981)
1856:(2024)
1850:(2023)
1840:(2022)
1830:(2021)
1820:(2020)
1810:(2019)
1804:(2018)
1798:(2017)
1788:(2016)
1782:(2015)
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1760:(2012)
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153:Fields
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83:Awards
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