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Bifidobacterium longum

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infection have been reported in the scientific literature. These are primarily cases in preterm infants that are undergoing probiotic treatment, although there are also reports of infection in adults. Infection in preterm infants manifests as bacteremia or necrotizing enterocolitis, while in adults
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De Vrese, M.; Winkler, P.; Rautenberg, P.; Harder, T.; Noah, C.; Laue, C.; Ott, S.; Hampe, J.; Schreiber, S.; Heller, K.; Schrezenmeir, J. R. (2005). "Effect of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B. Bifidum MF 20/5 on common cold episodes: A double blind, randomized,
962:Šrůtková, Dagmar; Španova, Alena; Špano, Miroslav; Dráb, Vladimír; Schwarzer, Martin; Kozaková, Hana; Rittich, Bohuslav (October 2011). "Efficiency of PCR-based methods in discriminating Bifidobacterium longum ssp. longum and Bifidobacterium longum ssp. infantis strains of human origin". 840:
Yuan, Jing; Zhu, Li; Liu, Xiankai; Li, Ting; Zhang, Ying; Ying, Tianyi; Wang, Bin; Wang, Junjun; Dong, Hua; Feng, Erling; Li, Qiang; Wang, Jie; Wang, Hongxia; Wei, Kaihua; Zhang, Xuemin; Huang, Cuifeng; Huang, Peitang; Huang, Liuyu; Zeng, Ming; Wang, Hengliang (June 2006).
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Pasolli, Edoardo; Schiffer, Lucas; Manghi, Paolo; Renson, Audrey; Obenchain, Valerie; Truong, Duy Tin; Beghini, Francesco; Malik, Faizan; Ramos, Marcel; Dowd, Jennifer B; Huttenhower, Curtis; Morgan, Martin; Segata, Nicola; Waldron, Levi (November 2017).
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Bifidobacterium longum BB536 was discovered in the intestines of healthy breastfed infants in 1969. It is often used in nutritional supplement. In some small clinical trials, it has been shown to help defecation and relieve lactose intolerance symptoms.
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35624 before that and still marketed as such. It is sold under the brand name Align in the US and Canada and Alflorex in Ireland, the UK and other European countries. It is patented. This strain was isolated directly from the epithelium of the terminal
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of a healthy human subject, and is one of the most researched probiotic strains. Large scale clinical trials have shown that the strain is effective in controlling the symptoms of IBS including bloating, diarrhoea, abdominal pain and discomfort.
920:"Proposal to reclassify the three biotypes of Bifidobacterium longum as three subspecies: Bifidobacterium longum subsp. longum subsp. nov., Bifidobacterium longum subsp. infantis comb. nov. and Bifidobacterium longum subsp. suis comb. nov" 1701:
Takeda, Tsutomu; Asaoka, Daisuke; Nojiri, Shuko; Yanagisawa, Naotake; Nishizaki, Yuji; Osada, Taro; Koido, Shigeo; Nagahara, Akihito; Katsumata, Noriko; Odamaki, Toshitaka; Xiao, Jin-Zhong; Ohkusa, Toshifumi; Sato, Nobuhiro (March 2023).
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Yazawa, Kazuyuki; Fujimori, Minoru; Amano, Jun; Kano, Yasunobu; Taniguchi, Shun'ichiro (February 2000). "Bifidobacterium longum as a delivery system for cancer gene therapy: Selective localization and growth in hypoxic tumors".
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Sakata, Shinji; Kitahara, Maki; Sakamoto, Mitsuo; Hayashi, Hidenori; Fukuyama, Masafumi; Benno, Yoshimi (1 November 2002). "Unification of Bifidobacterium infantis and Bifidobacterium suis as Bifidobacterium longum".
1761:"Effects of Bifidobacterium longum and Lactobacillus rhamnosus on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study" 388:
using glucosaminidases and alpha-mannosidases that participate in the fermentation of glucosamine and mannose, respectively. The high number of genes associated with oligosaccharide metabolism is a result of
274:, interest exists in the exact classification of new strains, although this is made difficult by the high gene similarity between the three biotypes. Currently, strain identification is done through 376:
to metabolise complex oligosaccharides for carbon and energy. This is necessary as mono- and disaccharides have usually been consumed by the time they reach the lower gastrointestinal tract where
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species, represents up to 90% of the bacteria of an infant's gastrointestinal tract. This number gradually drops to 3% in an adult's gastrointestinal tract as other enteric bacteria such as
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Parche, S.; Amon, J.; Jankovic, I.; Rezzonico, E.; Beleut, M.; Barutçu, H.; Schendel, I.; Eddy, M. P.; Burkovski, A.; Arigoni, F.; Titgemeyer, F. (2007). "Sugar Transport Systems of
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Abbad Andaloussi, S.; Talbaoui, H.; Marczak, R.; Bonaly, R. (November 1995). "Isolation and characterization of exocellular polysaccharides produced by Bifidobacterium longum".
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Tena, Daniel; Losa, Cristina; Medina, María José; Sáez-Nieto, Juan Antonio (June 2014). "Peritonitis caused by Bifidobacterium longum: Case report and literature review".
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Schell, M. A.; Karmirantzou, M.; Snel, B.; Vilanova, D.; Berger, B.; Pessi, G.; Zwahlen, M. -C.; Desiere, F.; Bork, P.; Delley, M.; Pridmore, R. D.; Arigoni, F. (2002).
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Whorwell, Peter J; Altringer, Linda; Morel, Jorge; Bond, Yvonne; Charbonneau, Duane; O'Mahony, Liam; Kiely, Barry; Shanahan, Fergus; Quigley, Eamonn M M (July 2006).
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Young Park, Shin; Lee, Do Kyung; Mi An, Hyang; Gyeong Cha, Min; Baek, Eun Hae; Rae Kim, Jung; Lee, Si Won; Kim, Mi Jin; Lee, Kang Oh; Joo Ha, Nam (1 July 2011).
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gene sequence similarity greater than 97%. In addition, the three original species were phenotypically difficult to distinguish due to different
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Minami, Miki; Tsuji, Shoji; Akagawa, Shohei; Akagawa, Yuko; Yoshimoto, Yuki; Kawakami, Hirosato; Kohno, Mamiko; Kaneko, Kazunari (2022-11-15).
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Bertelli, Claire; Pillonel, Trestan; Torregrossa, Anaïs; Prod'hom, Guy; Fischer, Céline Julie; Greub, Gilbert; Giannoni, Eric (15 March 2015).
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Wilson, Heather L.; Ong, Chong Wei (October 2017). "Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer".
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and considered to be one of the earliest colonizers of the gastrointestinal tract of infants. When grown on general anaerobic medium,
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is under selective pressure to increase its capability to compete for various substrates in the gastrointestinal tract. Furthermore,
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Xiao, J.Z.; Kondo, S.; Takahashi, N.; Miyaji, K.; Oshida, K.; Hiramatsu, A.; Iwatsuki, K.; Kokubo, S.; Hosono, A. (July 2003).
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structures and bacterial polysaccharides, the latter of which possess strong electrostatic charges that aid in the adhesion of
196:-negative, rod-shaped bacterium present in the human gastrointestinal tract and one of the 32 species that belong to the genus 1244:
Esaiassen, Eirin; Cavanagh, Pauline; Hjerde, Erik; Simonsen, Gunnar S.; Støen, Ragnhild; Klingenberg, Claus (September 2016).
1833: 2005: 1704:"Usefulness of Bifidobacterium longum BB536 in Elderly Individuals With Chronic Constipation: A Randomized Controlled Trial" 1759:
Vitellio, Paola; Celano, Giuseppe; Bonfrate, Leonilde; Gobbetti, Marco; Portincasa, Piero; De Angelis, Maria (2019-04-19).
56: 317:, suggesting that these strains would be able to survive the gastrointestinal tract to colonize the lower small and large 360:
pathways to use a large variety of nutrients to increase its competitiveness among the gut microbiota. Up to 19 types of
999:"Effects of Milk Products Fermented by Bifidobacterium longum on Blood Lipids in Rats and Healthy Adult Male Volunteers" 1559: 2082: 2077: 2031: 1926: 1644:"Effect of a Bifidobacterium-Containing Acid-Resistant Microcapsule Formulation on Gut Microbiota: A Pilot Study" 275: 466: 394: 1597:"Efficacy of an Encapsulated Probiotic Bifidobacterium infantis 35624 in Women with Irritable Bowel Syndrome" 214:
is one of the most common bifidobacteria present in the gastrointestinal tracts of both children and adults.
594:"The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract" 1888: 718: 326: 1842:"Bifidobacterium longum 1714™ Strain Modulates Brain Activity of Healthy Volunteers During Social Stress" 141: 270:
fermentation patterns among strains of the same species. As probiotic activity varies among strains of
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to hydrolyze bile salts into amino acids and bile acids. The function of this is not clear, although
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Garrido, D.; Ruiz-Moyano, S.; Jimenez-Espinoza, R.; Eom, H. J.; Block, D. E.; Mills, D. A. (2013).
414: 707:"Phenotypic and genotypic characterization of Bifidobacterium isolates from healthy adult Koreans" 1820: 1624: 1505: 1226: 1113: 1066: 817: 108: 98: 51: 1992: 2049: 1948: 1871: 1800: 1782: 1741: 1723: 1683: 1665: 1616: 1541: 1497: 1451: 1413: 1378: 1360: 1318: 1277: 1218: 1170: 1105: 1058: 1020: 979: 941: 900: 864: 809: 770: 687: 633: 338: 334: 2054: 1861: 1853: 1790: 1772: 1731: 1715: 1673: 1655: 1608: 1533: 1489: 1443: 1405: 1368: 1352: 1308: 1267: 1257: 1210: 1160: 1152: 1097: 1050: 1010: 971: 931: 892: 854: 801: 760: 752: 677: 669: 623: 613: 461:
was shown to shorten the duration and minimize the severity of symptoms associated with the
390: 658:"Utilization of galactooligosaccharides by Bifidobacterium longum subsp. Infantis isolates" 1015: 998: 198: 118: 1148: 1133:"Bile salt hydrolase of Bifidobacterium longum-biochemical and genetic characterization" 609: 1866: 1841: 1795: 1760: 1736: 1703: 1678: 1643: 1272: 1245: 765: 740: 682: 657: 78: 2018: 1165: 1132: 628: 593: 2071: 1612: 1373: 1340: 535: 189: 88: 1509: 1356: 1230: 1156: 1117: 1070: 1628: 1447: 1409: 843:"A Proteome Reference Map and Proteomic Analysis of Bifidobacterium longum NCC2705" 821: 520: 310: 267: 1953: 1857: 1719: 706: 1469:
Zbinden, Andrea; Zbinden, Reinhard; Berger, Christoph; Arlettaz, Romaine (2015).
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Zbinden, Andrea; Zbinden, Reinhard; Berger, Christoph; Arlettaz, Romaine (2015).
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Wang, Huiying; Braun, Christoph; Murphy, Eileen F.; Enck, Paul (July 2019).
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Ha, Gyoung Yim; Yang, Chang Heon; Kim, Heesoo; Chong, Yunsop (April 1999).
1322: 1297:"Bifidobacterium longum Bacteremia in Preterm Infants Receiving Probiotics" 1281: 1262: 1246:"Subspecies Bacteremia in 3 Extremely Preterm Infants Receiving Probiotics" 1222: 1174: 1109: 1024: 983: 945: 904: 868: 813: 805: 774: 691: 637: 618: 1834:
New Strain of Bifidobacterium May Help Improve Metabolic and Mental Health
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is non-pathogenic, is often added to food products, and its production of
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colonizes the human gastrointestinal tract, where it, along with other
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Mattarelli, P.; Bonaparte, C.; Pot, B.; Biavati, B. (1 April 2008).
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could use the amino acids products to better tolerate bile salts.
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International Journal of Systematic and Evolutionary Microbiology
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International Journal of Systematic and Evolutionary Microbiology
258:, respectively. This occurred as the three species had extensive 560: 314: 1966: 1886: 405:
possesses hydrolases, deaminases, and dehydratases to ferment
259: 741:"Accessible, curated metagenomic data through ExperimentHub" 337:. This adhesion is also enhanced by the fatty acids in the 1475:
Bacteremia in Three Preterm Infants on Probiotic Therapy"
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Bacteremia in Three Preterm Infants on Probiotic Therapy"
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exist to transport various carbohydrates with 13 being
278:(PCR) on the subtly different 16S rRNA gene sequences. 222:
is believed to prevent growth of pathogenic organisms.
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Tanaka, H.; Hashiba, H.; Kok, J.; Mierau, I. (2000).
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is considered to be a scavenger, possessing multiple
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in the gut is attributed to the glycoprotein-binding
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Journal of Molecular Microbiology and Biotechnology
434:there have been reports of sepsis and peritonitis. 210:forms white, glossy colonies with a convex shape. 1341:"Case of Sepsis Caused by Bifidobacterium longum" 598:Proceedings of the National Academy of Sciences 230:In 2002, three previously distinct species of 171:Representative morphologic characteristics of 8: 1836:. On: sci-news. Dec 22, 2020. About APC1472. 1569:. Procter & Gamble. 2007. Archived from 957: 955: 246:, were unified into a single species named 1883: 1036: 1034: 651: 649: 647: 42: 31: 1865: 1794: 1776: 1735: 1677: 1659: 1372: 1312: 1271: 1261: 1164: 1014: 935: 858: 786: 784: 764: 722: 681: 627: 617: 587: 585: 583: 581: 579: 577: 575: 573: 571: 1601:The American Journal of Gastroenterology 1429: 1427: 384:can uniquely ferment galactomannan-rich 1829:– the Bacterial Diversity Metadatabase 1334: 1332: 835: 833: 831: 546: 1137:Applied and Environmental Microbiology 1043:Applied Microbiology and Biotechnology 309:were found to have high tolerance for 7: 2042:2ecd3746-5a63-48ba-976e-4d7d2cf0bee6 1846:American Journal of Gastroenterology 1708:American Journal of Gastroenterology 847:Molecular & Cellular Proteomics 305:begin to dominate. Some strains of 964:Journal of Microbiological Methods 25: 1016:10.3168/jds.S0022-0302(03)73839-9 465:with a similar effect to that of 1613:10.1111/j.1572-0241.2006.00734.x 1564:35624) – Professional Monograph" 1345:Journal of Clinical Microbiology 711:Iranian Journal of Biotechnology 484:35624, previously classified as 55: 1357:10.1128/JCM.37.4.1227-1228.1999 1157:10.1128/aem.66.6.2502-2512.2000 1448:10.1016/j.anaerobe.2014.03.005 1410:10.1016/j.anaerobe.2017.04.004 1: 1858:10.14309/ajg.0000000000000203 1720:10.14309/ajg.0000000000002028 1301:Clinical Infectious Diseases 1250:Emerging Infectious Diseases 506:Bifidobacterium longum BB536 473:Bifidobacterium longum 35624 202:. It is a microaerotolerant 976:10.1016/j.mimet.2011.06.014 2109: 2093:Bacteria described in 1963 1538:10.1016/j.clnu.2005.02.006 897:10.1099/00207713-52-6-1945 860:10.1074/mcp.M500410-MCP200 160:1963 (Approved Lists 1980) 276:polymerase chain reaction 147: 140: 52:Scientific classification 50: 41: 34: 1562:Bifidobacterium infantis 1003:Journal of Dairy Science 674:10.1016/j.fm.2012.10.003 494:Bifidobacterium infantis 467:neuraminidase inhibitors 453:Immune system regulation 395:horizontal gene transfer 1086:Bifidobacterium longum 380:resides. In addition, 262:similarity including a 2019:bifidobacterium-longum 1927:Bifidobacterium longum 1897:Bifidobacterium longum 1823:Bifidobacterium longum 1473:Bifidobacterium longum 1263:10.3201/eid2209.160033 1193:Bifidobacterium longum 806:10.1038/sj.cgt.7700122 619:10.1073/pnas.212527599 486:Bifidobacterium longum 478:Bifidobacterium longum 185:Bifidobacterium longum 180: 151:Bifidobacterium longum 36:Bifidobacterium longum 937:10.1099/ijs.0.65319-0 492:35624, classified as 429:A number of cases of 372:has several glycosyl 321:. The persistence of 170: 445:is a constituent in 415:bile salt hydrolases 366:ATP-binding cassette 27:Species of bacterium 1524:controlled trial". 1149:2000ApEnM..66.2502T 794:Cancer Gene Therapy 610:2002PNAS...9914422S 604:(22): 14422–14427. 2083:Gut flora bacteria 1778:10.3390/nu11040886 1661:10.3390/nu14224829 1526:Clinical Nutrition 1314:10.1093/cid/ciu946 1055:10.1007/BF00166915 757:10.1038/nmeth.4468 397:, indicating that 250:with the biotypes 181: 109:Bifidobacteriaceae 2078:Bifidobacteriales 2065: 2064: 2050:Open Tree of Life 1889:Taxon identifiers 1494:10.1159/000367985 1215:10.1159/000367985 1102:10.1159/000096455 751:(11): 1023–1024. 662:Food Microbiology 556:"Bifidobacterium" 339:lipoteichoic acid 335:endothelial cells 252:infantis, longum, 165: 164: 99:Bifidobacteriales 16:(Redirected from 2100: 2058: 2057: 2045: 2044: 2035: 2034: 2022: 2021: 2009: 2008: 1996: 1995: 1983: 1982: 1970: 1969: 1957: 1956: 1944: 1943: 1931: 1930: 1929: 1916: 1915: 1914: 1884: 1879: 1869: 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infantis 220:lactic acid 2088:Probiotics 2072:Categories 1771:(4): 886. 1088:NCC2705". 542:References 374:hydrolases 349:Metabolism 319:intestines 1787:2072-6643 1765:Nutrients 1728:0002-9270 1670:2072-6643 1648:Nutrients 1580:4 January 1442:: 27–30. 1404:: 47–50. 1365:0095-1137 719:CiteSeerX 531:Gut flora 526:Probiotic 459:B. longum 443:B. longum 431:B. longum 419:B. longum 413:also has 411:B. longum 403:B. longum 399:B. longum 382:B. longum 378:B. longum 370:B. longum 358:catabolic 354:B. longum 343:B. longum 331:B. longum 323:B. longum 307:B. longum 287:B. longum 272:B. longum 248:B. longum 240:B. longum 216:B. longum 212:B. longum 208:B. longum 173:B. longum 127:Species: 18:B. longum 1993:10029731 1912:Q4904768 1906:Wikidata 1876:30998517 1805:31010241 1746:36216361 1688:36432516 1621:16863564 1546:16054520 1510:33816095 1502:25402825 1456:24657157 1436:Anaerobe 1418:28408274 1398:Anaerobe 1383:10074561 1323:25472946 1282:27532215 1231:33816095 1223:25402825 1175:10831430 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Index

B. longum

Scientific classification
Edit this classification
Bacteria
Actinomycetota
Actinomycetia
Bifidobacteriales
Bifidobacteriaceae
Bifidobacterium
Binomial name
Reuter

Gram-positive
catalase
Bifidobacterium
anaerobe
lactic acid
DNA
16S rRNA
carbohydrate
polymerase chain reaction
Bacteroides
Eubacterium
gastric acid
bile
intestines
fimbriae
endothelial cells
lipoteichoic acid

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