302:
279:
176:
201:
29:
308:
207:
1679:
2410:
1036:, especially in the avian embryo. The first antibody raised against this epitope was NC-1, which permitted much easier analyses of neural crest migration pathways. In avians, and especially in other vertebrates, the results of HNK-1 staining should be interpreted with caution as the epitope is not unique to the neural crest.
1023:
The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids containing a Gal-beta-1-4GlcNAc or Gal-beta-1-3GlcNAc residue. The
55:
1131:
Imiya K, Ishizaki T, Seiki T, Saito F, Inazawa J, Oka S, Kawasaki T (Oct 2002). "cDNA cloning, genomic structure and chromosomal mapping of the mouse glucuronyltransferase-S involved in the biosynthesis of the HNK-1 carbohydrate epitope".
1848:
1843:
1024:
encoded protein is involved in the synthesis of the human natural killer-1 (HNK-1) carbohydrate epitope, a sulfated trisaccharide implicated in cellular migration and adhesion in the nervous system.
1492:
Kakuda S, Oka S, Kawasaki T (2004). "Purification and characterization of two recombinant human glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate in
Escherichia coli".
2221:
2097:
1599:
Shiba T, Kakuda S, Ishiguro M, et al. (2006). "Crystal structure of GlcAT-S, a human glucuronyltransferase, involved in the biosynthesis of the HNK-1 carbohydrate epitope".
1888:
315:
214:
2202:
2270:
1719:
1279:
2379:
2349:
1219:
Vincent M, Thiery JP (June 1984). "A cell surface marker for neural crest and placodal cells: further evolution in peripheral and central nervous system".
747:
728:
137:
2024:
2019:
1293:"Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins"
1558:"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"
2479:
2384:
1184:
Bronner-Fraser M (May 1986). "Analysis of the early stages of trunk neural crest migration in avian embryos using monoclonal antibody HNK-1".
1113:
1095:
2455:
1658:
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1258:
301:
1712:
947:
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52:
1705:
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1815:
117:
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2240:
1523:"Different acceptor specificities of two glucuronyltransferases involved in the biosynthesis of HNK-1 carbohydrate"
307:
206:
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189:
2174:
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1987:
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1270:
104:
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2011:
1749:
1624:
149:
1328:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
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224:
145:
2079:
2074:
2226:
369:
1431:
1343:
28:
1582:
1557:
1032:
Antibodies raised against the HNK-1 epitope have played a large role in studies of the
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1327:
1145:
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652:
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621:
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1197:
572:
1628:
129:
2421:
1033:
387:
166:
1171:"Entrez Gene: B3GAT2 beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)"
153:
1728:
1118:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1100:
National Center for
Biotechnology Information, U.S. National Library of Medicine
470:
1505:
286:
183:
133:
1381:"Cloning, characterization, and chromosome mapping of the human GlcAT-S gene"
1309:
1292:
1539:
1522:
1459:"Complete sequencing and characterization of 21,243 full-length human cDNAs"
692:
530:
408:
353:
340:
252:
239:
141:
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1513:
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1406:
1371:
1352:
1318:
1153:
1397:
1380:
1240:
1205:
994:
989:
596:
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
978:
837:
818:
1440:
1415:
2389:
2247:
1980:
1975:
1970:
1965:
1960:
1928:
1852:
1612:
1573:
804:
759:
74:
2185:
1955:
1950:
1945:
1940:
1935:
1923:
1918:
1913:
1908:
1903:
1898:
1893:
1881:
1871:
1010:
962:
714:
2409:
1475:
1458:
1007:
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2
2337:
2332:
2305:
2156:
2107:
2102:
677:
673:
2417:
2151:
2146:
2141:
2136:
2131:
2126:
2119:
2114:
2069:
2064:
2059:
2054:
2049:
2044:
2034:
2029:
2001:
1996:
1991:
1017:
121:
1849:
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase
1844:
B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase
1701:
1640:
1636:
1326:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
377:
2429:
2098:
Dolichyl-phosphate-mannose-protein mannosyltransferase
1556:
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006).
1416:"The DNA sequence and analysis of human chromosome 6"
653:
chondroitin sulfate proteoglycan biosynthetic process
542:
1414:
Mungall AJ, Palmer SA, Sims SK, et al. (2003).
2364:
2320:
2289:
2256:
2193:
2184:
2169:
2088:
2010:
1862:
1829:
1759:
1744:
923:
902:
876:
855:
505:
dentate gyrus of hippocampal formation granule cell
1521:Kakuda S, Sato Y, Tonoyama Y, et al. (2005).
1457:Ota T, Suzuki Y, Nishikawa T, et al. (2004).
1379:Marcos I, Galán JJ, Borrego S, Antiñolo G (2003).
1074:
1072:
1070:
1053:
1051:
1049:
324:
223:
1028:Use of HNK-1 Antibody for Neural Crest Research
16:Protein-coding gene in the species Homo sapiens
2271:Hypoxanthine-guanine phosphoribosyltransferase
1079:GRCm38: Ensembl release 89: ENSMUSG00000026156
2449:
1713:
1687:: Crystal Structure of Human GlcAT-S Apo Form
1652:
8:
2380:Beta-galactoside alpha-2,6-sialyltransferase
2350:Indolylacetylinositol arabinosyltransferase
1058:GRCh38: Ensembl release 89: ENSG00000112309
2456:
2442:
2190:
2181:
1756:
1720:
1706:
1698:
1659:
1645:
1637:
688:
568:
365:
264:
161:
108:, GLCATS, beta-1,3-glucuronyltransferase 2
63:
1581:
1538:
1474:
1439:
1396:
1361:
1351:
1308:
1165:
1163:
1674:
1045:
2385:Monosialoganglioside sialyltransferase
2222:NAD(P):arginine ADP-ribosyltransferase
2203:NAD:diphthamide ADP-ribosyltransferase
18:
658:chondroitin sulfate metabolic process
329:
290:
285:
228:
187:
182:
7:
2406:
2404:
1291:Nagase T, Kikuno R, Ohara O (2002).
643:glycosaminoglycan metabolic process
2428:. You can help Knowledge (XXG) by
920:
899:
873:
852:
828:
809:
783:
764:
738:
719:
547:
465:
403:
382:
14:
2266:Adenine phosphoribosyltransferase
1013:that in humans is encoded by the
2408:
2276:Uracil phosphoribosyltransferase
1677:
313:
306:
300:
277:
212:
205:
199:
174:
27:
2297:Purine nucleoside phosphorylase
2281:Amidophosphoribosyltransferase
663:carbohydrate metabolic process
612:integral component of membrane
531:More reference expression data
1:
2480:Human chromosome 6 gene stubs
1146:10.1016/S0378-1119(02)00840-5
298:
197:
1816:Ceramide glucosyltransferase
1332:Proc. Natl. Acad. Sci. U.S.A
1233:10.1016/0012-1606(84)90334-8
1198:10.1016/0012-1606(86)90226-5
2475:Genes on human chromosome 6
2496:
2403:
2241:Poly ADP ribose polymerase
1269:gene details page in the
2258:Phosphoribosyltransferase
1672:
1506:10.1016/j.pep.2003.12.021
1114:"Mouse PubMed Reference:"
1096:"Human PubMed Reference:"
993:
988:
984:
977:
961:
942:
927:
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895:
880:
859:
848:
835:
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541:
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297:
276:
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246:
233:
196:
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164:
160:
115:
112:
102:
95:
90:
71:
66:
49:
44:
39:
35:
26:
21:
1811:1,3-Beta-glucan synthase
2301:Thymidine phosphorylase
948:Chr 6: 70.86 – 70.96 Mb
2195:ADP-ribosyltransferase
1353:10.1073/pnas.242603899
1310:10.1093/dnares/8.6.319
955:Chr 1: 23.8 – 23.89 Mb
513:superior frontal gyrus
2345:Arabinosyltransferase
1821:N-glycosyltransferase
1540:10.1093/glycob/cwi001
1398:10.1007/s100380200103
648:protein glycosylation
509:primary visual cortex
2213:Pseudomonas exotoxin
1733:glycosyltransferases
1263:genome location and
586:transferase activity
292:Chromosome 1 (mouse)
190:Chromosome 6 (human)
67:List of PDB id codes
40:Available structures
1988:Hyaluronan synthase
1494:Protein Expr. Purif
1441:10.1038/nature02055
1432:2003Natur.425..805M
1344:2002PNAS...9916899M
1271:UCSC Genome Browser
427:ganglionic eminence
2416:This article on a
2328:Xylosyltransferase
1801:Debranching enzyme
1613:10.1002/prot.21118
1574:10.1101/gr.4039406
793:ENSMUSG00000026156
636:Biological process
605:Cellular component
579:Molecular function
447:hippocampus proper
431:buccal mucosa cell
154:B3GAT2 - orthologs
2437:
2436:
2398:
2397:
2360:
2359:
2316:
2315:
2165:
2164:
1796:Glycogen synthase
1695:
1694:
1338:(26): 16899–903.
1004:
1003:
1000:
999:
973:
972:
938:
937:
917:
916:
891:
890:
870:
869:
844:
843:
825:
824:
799:
798:
780:
779:
754:
753:
735:
734:
683:
682:
591:metal ion binding
563:
562:
559:
558:
537:
536:
524:
523:
462:
461:
443:postcentral gyrus
423:entorhinal cortex
360:
359:
259:
258:
86:
85:
82:
81:
50:Ortholog search:
2487:
2458:
2451:
2444:
2412:
2405:
2208:Diphtheria toxin
2191:
2182:
1839:Lactose synthase
1806:Branching enzyme
1757:
1722:
1715:
1708:
1699:
1681:
1661:
1654:
1647:
1638:
1632:
1595:
1585:
1552:
1542:
1517:
1488:
1478:
1453:
1443:
1426:(6960): 805–11.
1410:
1400:
1375:
1365:
1355:
1322:
1312:
1245:
1244:
1216:
1210:
1209:
1181:
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1128:
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1103:
1092:
1086:
1076:
1065:
1055:
986:
985:
957:
950:
933:
921:
912:
900:
896:RefSeq (protein)
886:
874:
865:
853:
829:
810:
784:
765:
739:
720:
689:
569:
548:
533:
489:ventricular zone
473:
471:Top expressed in
466:
451:endothelial cell
439:Brodmann area 46
419:ventricular zone
411:
409:Top expressed in
404:
383:
366:
356:
343:
332:
317:
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304:
293:
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265:
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37:
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31:
19:
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2464:
2463:
2462:
2401:
2399:
2394:
2371:
2356:
2312:
2285:
2252:
2227:Pertussis toxin
2176:
2161:
2084:
2006:
1858:
1825:
1751:
1740:
1726:
1696:
1691:
1688:
1682:
1668:
1665:
1635:
1598:
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1520:
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1456:
1413:
1378:
1325:
1290:
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1284:Further reading
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1094:
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1077:
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1056:
1047:
1042:
1030:
995:View/Edit Mouse
990:View/Edit Human
953:
946:
943:Location (UCSC)
929:
908:
882:
861:
774:ENSG00000112309
667:
631:
617:Golgi apparatus
600:
529:
520:
515:
511:
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491:
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481:proximal tubule
469:
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455:corpus callosum
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268:Gene location (
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165:Gene location (
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2014:
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2004:
1999:
1994:
1984:
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1968:
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1634:
1633:
1607:(2): 499–508.
1596:
1553:
1518:
1489:
1476:10.1038/ng1285
1454:
1411:
1391:(12): 677–80.
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1253:
1252:External links
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1159:
1140:(1–2): 29–36.
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627:Golgi membrane
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370:RNA expression
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2336:
2334:
2331:
2330:
2329:
2326:
2325:
2323:
2319:
2307:
2304:
2303:
2302:
2298:
2295:
2294:
2292:
2288:
2282:
2279:
2277:
2274:
2272:
2269:
2267:
2264:
2263:
2261:
2259:
2255:
2249:
2246:
2245:
2242:
2239:
2238:
2233:
2232:Cholera toxin
2230:
2228:
2225:
2224:
2223:
2220:
2219:
2214:
2211:
2209:
2206:
2205:
2204:
2201:
2200:
2198:
2196:
2192:
2189:
2187:
2183:
2180:
2178:
2172:
2168:
2158:
2155:
2153:
2150:
2148:
2145:
2143:
2140:
2138:
2135:
2133:
2130:
2128:
2125:
2124:
2121:
2118:
2116:
2113:
2109:
2106:
2104:
2101:
2100:
2099:
2096:
2095:
2093:
2091:
2087:
2081:
2078:
2076:
2073:
2071:
2068:
2066:
2063:
2061:
2058:
2056:
2053:
2051:
2048:
2046:
2043:
2041:
2038:
2036:
2033:
2031:
2028:
2026:
2023:
2021:
2018:
2017:
2015:
2013:
2009:
2003:
2000:
1998:
1995:
1993:
1989:
1986:
1985:
1982:
1979:
1977:
1974:
1972:
1969:
1967:
1964:
1962:
1959:
1957:
1954:
1952:
1949:
1947:
1944:
1942:
1939:
1937:
1934:
1933:
1930:
1927:
1925:
1922:
1920:
1917:
1915:
1912:
1910:
1907:
1905:
1902:
1900:
1897:
1895:
1892:
1890:
1887:
1886:
1883:
1880:
1878:
1875:
1873:
1870:
1869:
1867:
1865:
1864:Glucuronosyl-
1861:
1854:
1850:
1847:
1845:
1842:
1840:
1837:
1836:
1834:
1832:
1828:
1822:
1819:
1817:
1814:
1812:
1809:
1807:
1804:
1802:
1799:
1797:
1794:
1790:
1787:
1785:
1782:
1780:
1777:
1775:
1772:
1771:
1770:
1769:Phosphorylase
1767:
1766:
1764:
1762:
1758:
1755:
1753:
1747:
1743:
1738:
1734:
1730:
1723:
1718:
1716:
1711:
1709:
1704:
1703:
1700:
1686:
1680:
1675:
1671:
1662:
1657:
1655:
1650:
1648:
1643:
1642:
1639:
1630:
1626:
1622:
1618:
1614:
1610:
1606:
1602:
1597:
1593:
1589:
1584:
1579:
1575:
1571:
1567:
1563:
1559:
1554:
1550:
1546:
1541:
1536:
1533:(2): 203–10.
1532:
1528:
1524:
1519:
1515:
1511:
1507:
1503:
1499:
1495:
1490:
1486:
1482:
1477:
1472:
1468:
1464:
1460:
1455:
1451:
1447:
1442:
1437:
1433:
1429:
1425:
1421:
1417:
1412:
1408:
1404:
1399:
1394:
1390:
1386:
1385:J. Hum. Genet
1382:
1377:
1373:
1369:
1364:
1359:
1354:
1349:
1345:
1341:
1337:
1333:
1329:
1324:
1320:
1316:
1311:
1306:
1303:(6): 319–27.
1302:
1298:
1294:
1289:
1288:
1283:
1278:
1275:
1272:
1268:
1267:
1262:
1261:
1256:
1255:
1251:
1242:
1238:
1234:
1230:
1227:(2): 468–81.
1226:
1222:
1215:
1212:
1207:
1203:
1199:
1195:
1191:
1187:
1180:
1177:
1172:
1166:
1164:
1160:
1155:
1151:
1147:
1143:
1139:
1135:
1127:
1124:
1119:
1115:
1109:
1106:
1101:
1097:
1091:
1088:
1084:
1080:
1075:
1073:
1071:
1067:
1063:
1059:
1054:
1052:
1050:
1046:
1039:
1037:
1035:
1027:
1025:
1021:
1019:
1016:
1012:
1008:
996:
991:
987:
983:
980:
976:
969:
967:
964:
960:
956:
952:
949:
945:
941:
934:
932:
926:
922:
919:
913:
911:
905:
901:
898:
894:
887:
885:
879:
875:
872:
866:
864:
858:
854:
851:
849:RefSeq (mRNA)
847:
840:
839:
834:
830:
827:
821:
820:
815:
811:
808:
806:
802:
795:
794:
789:
785:
782:
776:
775:
770:
766:
763:
761:
757:
750:
749:
744:
740:
737:
731:
730:
725:
721:
718:
716:
712:
709:
706:
704:
701:
697:
694:
690:
686:
679:
675:
670:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
640:
638:
635:
634:
628:
625:
623:
620:
618:
615:
613:
610:
609:
607:
604:
603:
597:
594:
592:
589:
587:
584:
583:
581:
578:
577:
574:
573:Gene ontology
570:
566:
554:
549:
546:
544:
540:
532:
527:
516:
512:
508:
504:
500:
496:
492:
488:
484:
480:
479:
476:
472:
467:
464:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
417:
414:
410:
405:
402:
401:
398:
396:
392:
390:
389:
385:
384:
381:
379:
375:
371:
367:
363:
355:
350:
346:
342:
337:
327:
323:
316:
309:
303:
296:
288:
284:
280:
275:
271:
266:
262:
254:
249:
245:
241:
236:
226:
222:
215:
208:
202:
195:
191:
185:
181:
177:
172:
168:
163:
159:
155:
151:
147:
143:
139:
135:
131:
127:
123:
119:
111:
106:
99:
94:
89:
78:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
2430:expanding it
2422:chromosome 6
2415:
2400:
2372:transferases
2177:transferases
1876:
1752:transferases
1729:Transferases
1684:
1604:
1600:
1568:(1): 55–65.
1565:
1561:
1530:
1527:Glycobiology
1526:
1500:(1): 111–9.
1497:
1493:
1466:
1462:
1423:
1419:
1388:
1384:
1335:
1331:
1300:
1296:
1265:
1259:
1224:
1220:
1214:
1192:(1): 44–55.
1189:
1185:
1179:
1137:
1133:
1126:
1117:
1108:
1099:
1090:
1034:neural crest
1031:
1022:
1014:
1006:
1005:
928:
907:
881:
860:
836:
817:
791:
772:
746:
727:
707:
702:
497:human kidney
485:right kidney
393:
386:
113:External IDs
72:
1831:Galactosyl-
1667:PDB gallery
1469:(1): 40–5.
517:neural tube
352:23,888,239
339:23,800,834
331:1|1 A5
251:70,957,060
238:70,856,679
91:Identifiers
2469:Categories
1784:Cellobiose
1562:Genome Res
1463:Nat. Genet
1085:, May 2017
1064:, May 2017
1040:References
397:(ortholog)
134:HomoloGene
2420:on human
2175:Pentosyl-
2090:Mannosyl-
1761:Glucosyl-
1221:Dev. Biol
1186:Dev. Biol
931:NP_742122
910:NP_542780
884:NM_172124
863:NM_080742
693:Orthologs
142:GeneCards
2012:Fucosyl-
1779:Glycogen
1750:Hexosyl-
1629:31290955
1621:16897771
1601:Proteins
1592:16344560
1549:15470230
1514:15039073
1485:14702039
1450:14574404
1407:12522689
1372:12477932
1319:11853319
1154:12383500
1081:–
1060:–
979:Wikidata
672:Sources:
622:membrane
2390:ST8SIA4
2248:Sirtuin
1981:UGT2B28
1976:UGT2B17
1971:UGT2B15
1966:UGT2B11
1961:UGT2B10
1929:UGT1A10
1853:C1GALT1
1583:1356129
1428:Bibcode
1340:Bibcode
1297:DNA Res
1277:PDBe-KB
1241:6202575
1206:3516760
1083:Ensembl
1062:Ensembl
805:UniProt
760:Ensembl
699:Species
678:QuickGO
493:urethra
372:pattern
130:2389490
98:Aliases
2370:Sialyl
2366:2.4.99
2186:Ribose
2025:POFUT2
2020:POFUT1
1956:UGT2B7
1951:UGT2B4
1946:UGT2A3
1941:UGT2A2
1936:UGT2A1
1924:UGT1A9
1919:UGT1A8
1914:UGT1A7
1909:UGT1A6
1904:UGT1A5
1899:UGT1A4
1894:UGT1A3
1889:UGT1A1
1882:B3GAT3
1877:B3GAT2
1872:B3GAT1
1774:Starch
1627:
1619:
1590:
1580:
1547:
1512:
1483:
1448:
1420:Nature
1405:
1370:
1363:139241
1360:
1317:
1266:B3GAT2
1260:B3GAT2
1257:Human
1239:
1204:
1152:
1015:B3GAT2
1011:enzyme
1009:is an
965:search
963:PubMed
838:P59270
819:Q9NPZ5
748:280645
729:135152
715:Entrez
543:BioGPS
501:zygote
146:B3GAT2
122:607497
105:B3GAT2
22:B3GAT2
2424:is a
2338:XYLT2
2333:XYLT1
2321:Other
2306:ECGF1
2290:Other
2171:2.4.2
2157:ALG12
2108:POMT2
2103:POMT1
2080:FUT11
2075:FUT10
1746:2.4.1
1625:S2CID
708:Mouse
703:Human
674:Amigo
395:Mouse
388:Human
335:Start
270:Mouse
234:Start
167:Human
138:50574
2426:stub
2418:gene
2152:ALG9
2147:ALG8
2142:ALG6
2137:ALG3
2132:ALG2
2127:ALG1
2120:DPM3
2115:DPM1
2070:FUT9
2065:FUT8
2060:FUT7
2055:FUT6
2050:FUT5
2045:FUT4
2040:FUT3
2035:FUT2
2030:FUT1
2002:HAS3
1997:HAS2
1992:HAS1
1789:Myo-
1739:2.4)
1685:2d0j
1617:PMID
1588:PMID
1545:PMID
1510:PMID
1481:PMID
1446:PMID
1403:PMID
1368:PMID
1315:PMID
1237:PMID
1202:PMID
1150:PMID
1134:Gene
1018:gene
435:pons
378:Bgee
326:Band
287:Chr.
230:6q13
225:Band
184:Chr.
118:OMIM
75:2D0J
56:RCSB
53:PDBe
1609:doi
1578:PMC
1570:doi
1535:doi
1502:doi
1471:doi
1436:doi
1424:425
1393:doi
1358:PMC
1348:doi
1305:doi
1229:doi
1225:103
1194:doi
1190:115
1142:doi
1138:296
551:n/a
348:End
247:End
150:OMA
126:MGI
46:PDB
2471::
2368::
2299::
2173::
1990::
1748::
1737:EC
1731::
1623:.
1615:.
1605:65
1603:.
1586:.
1576:.
1566:16
1564:.
1560:.
1543:.
1531:15
1529:.
1525:.
1508:.
1498:35
1496:.
1479:.
1467:36
1465:.
1461:.
1444:.
1434:.
1422:.
1418:.
1401:.
1389:47
1387:.
1383:.
1366:.
1356:.
1346:.
1336:99
1334:.
1330:.
1313:.
1299:.
1295:.
1235:.
1223:.
1200:.
1188:.
1162:^
1148:.
1136:.
1116:.
1098:.
1069:^
1048:^
1020:.
676:/
354:bp
341:bp
253:bp
240:bp
148:;
144::
140:;
136::
132:;
128::
124:;
120::
2457:e
2450:t
2443:v
2432:.
1855:)
1851:(
1735:(
1721:e
1714:t
1707:v
1660:e
1653:t
1646:v
1631:.
1611::
1594:.
1572::
1551:.
1537::
1516:.
1504::
1487:.
1473::
1452:.
1438::
1430::
1409:.
1395::
1374:.
1350::
1342::
1321:.
1307::
1301:8
1273:.
1243:.
1231::
1208:.
1196::
1173:.
1156:.
1144::
1120:.
1102:.
272:)
169:)
152::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
