299:
276:
173:
198:
305:
204:
2239:
Zhang Q, Siebert R, Yan M, Hinzmann B, Cui X, Xue L, Rakestraw KM, Naeve CW, Beckmann G, Weisenburger DD, Sanger WG, Nowotny H, Vesely M, Callet-Bauchu E, Salles G, Dixit VM, Rosenthal A, Schlegelberger B, Morris SW (1999). "Inactivating mutations and overexpression of BCL10, a caspase recruitment
1373:, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl10 thought to synergize in the activation of NF-ΞΊB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Bcl10 is evolutionary conserved since
52:
2113:
Lee WC, Balsara B, Liu Z, Jhanwar SC, Testa JR (1996). "Loss of heterozygosity analysis defines a critical region in chromosome 1p22 commonly deleted in human malignant mesothelioma".
2680:"CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B"
1776:"CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B"
1554:
Willis TG, Jadayel DM, Du MQ, Peng H, Perry AR, Abdul-Rauf M, Price H, Karran L, Majekodunmi O, Wlodarska I, Pan L, Crook T, Hamoudi R, Isaacson PG, Dyer MJ (March 1999).
2013:
Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (April 2000).
1335:
312:
211:
2382:
Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M (2000).
2532:"vCLAP, a caspase-recruitment domain-containing protein of equine Herpesvirus-2, persistently activates the Ikappa B kinases through oligomerization of IKKgamma"
2349:"c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB"
1620:
Mazzone P, Scudiero I, Ferravante A, Paolucci M, D'Andrea LE, Varricchio E, Telesio G, De Maio C, Pizzulo M, Zotti T, Reale C, Vito P, Stilo R (April 2015).
2279:"CLAP, a novel caspase recruitment domain-containing protein in the tumor necrosis factor receptor pathway, regulates NF-kappaB activation and apoptosis"
1014:
995:
134:
2610:"Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B"
1732:"Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B"
105:, CARMEN, CIPER, CLAP, c-E10, mE10, IMD37, B-cell CLL/lymphoma 10, B cell CLL/lymphoma 10, immune signaling adaptor, BCL10 immune signaling adaptor
2497:"Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma"
1974:"Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma"
2171:"Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase"
1536:
1823:
Bertin J, Guo Y, Wang L, Srinivasula SM, Jacobson MD, Poyet JL, Merriam S, Du MQ, Dyer MJ, Robison KE, DiStefano PS, Alnemri ES (Dec 2000).
1518:
2774:
49:
2460:
Bertin J, Guo Y, Wang L, Srinivasula SM, Jacobson MD, Poyet JL, Merriam S, Du MQ, Dyer MJ, Robison KE, DiStefano PS, Alnemri ES (2001).
2645:"Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway"
298:
2057:
1233:
1226:
2565:
Ruland J, Duncan GS, Elia A, del Barco
Barrantes I, Nguyen L, Plyte S, Millar DG, Bouchard D, Wakeham A, Ohashi PS, Mak TW (2001).
275:
1866:"Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes"
1606:
2136:"CIPER, a novel NF kappaB-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10"
2784:
1505:
1484:
1730:
Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (June 2001).
1681:"Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions"
1501:
1366:, which are thought to function as upstream regulators in NF-ΞΊB signaling. This protein is found to form a complex with the
2063:
197:
172:
1480:
2608:
Wang L, Guo Y, Huang WJ, Ke X, Poyet JL, Manji GA, Merriam S, Glucksmann MA, DiStefano PS, Alnemri ES, Bertin J (2001).
2462:"CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B"
1825:"CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B"
114:
1406:
2084:
Bertoni F, Cavalli F, Cotter FE, Zucca E (2003). "Genetic alterations underlying the pathogenesis of MALT lymphoma".
311:
210:
1774:
Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (April 2001).
304:
203:
1331:
1059:
122:
2643:
Lucas PC, Yonezumi M, Inohara N, McAllister-Lucas LM, Abazeed ME, Chen FF, Yamaoka S, Seto M, Nunez G (2001).
2723:"Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation"
2678:
Bertin J, Wang L, Guo Y, Jacobson MD, Poyet JL, Srinivasula SM, Merriam S, DiStefano PS, Alnemri ES (2001).
1040:
2567:"Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure"
2384:"Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein"
2015:"Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein"
1915:"NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation"
1926:
1633:
1188:
186:
2069:
1556:"Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types"
1180:
1133:
101:
2419:"BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma"
2752:
2709:
2596:
2265:
1805:
1585:
146:
2277:
Srinivasula SM, Ahmad M, Lin JH, Poyet JL, Fernandes-Alnemri T, Tsichlis PN, Alnemri ES (1999).
1972:
Uren AG, O'Rourke K, Aravind LA, Pisabarro MT, Seshagiri S, Koonin EV, Dixit VM (October 2000).
1209:
1184:
1154:
1129:
2169:
Thome M, Martinon F, Hofmann K, Rubio V, Steiner V, Schneider P, Mattmann C, Tschopp J (1999).
2779:
2744:
2701:
2666:
2631:
2588:
2553:
2518:
2483:
2448:
2405:
2370:
2335:
2300:
2257:
2227:
2192:
2157:
2122:
2101:
2036:
1995:
1954:
1895:
1846:
1797:
1753:
1712:
1661:
1577:
94:
42:
2417:
Ye H, Dogan A, Karran L, Willis TG, Chen L, Wlodarska I, Dyer MJ, Isaacson PG, Du MQ (2000).
2734:
2691:
2656:
2621:
2578:
2543:
2508:
2473:
2438:
2430:
2395:
2360:
2325:
2290:
2249:
2217:
2182:
2147:
2093:
2026:
1985:
1944:
1934:
1885:
1877:
1836:
1787:
1743:
1702:
1692:
1651:
1641:
1567:
391:
322:
266:
221:
142:
366:
815:
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
2495:
Uren AG, O'Rourke K, Aravind LA, Pisabarro MT, Seshagiri S, Koonin EV, Dixit VM (2000).
2134:
Koseki T, Inohara N, Chen S, Carrio R, Merino J, Hottiger MO, Nabel GJ, NΓΊΓ±ez G (1999).
1930:
1637:
2443:
2418:
1949:
1914:
1890:
1865:
1707:
1680:
1656:
1621:
1382:
1347:
2739:
2722:
2583:
2566:
2513:
2496:
2434:
2330:
2313:
1990:
1973:
1572:
1555:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
754:
749:
744:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
652:
647:
642:
637:
632:
627:
622:
617:
612:
607:
602:
597:
592:
587:
582:
2768:
569:
2756:
2713:
1809:
126:
2600:
2269:
1589:
1394:
384:
163:
1679:
Staal J, Driege Y, Haegman M, Borghi A, Hulpiau P, Lievens L, et al. (2018).
1646:
150:
1541:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1523:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1367:
1339:
467:
283:
180:
130:
2400:
2383:
2365:
2348:
2295:
2278:
2222:
2205:
2031:
2014:
1881:
1697:
2187:
2170:
2152:
2135:
1939:
1390:
1378:
959:
527:
405:
350:
337:
249:
236:
138:
2748:
2705:
2696:
2679:
2670:
2661:
2644:
2635:
2626:
2609:
2592:
2557:
2548:
2531:
2522:
2487:
2478:
2461:
2452:
2409:
2374:
2339:
2304:
2261:
2231:
2206:"mE10, a novel caspase recruitment domain-containing proapoptotic molecule"
2196:
2161:
2105:
2097:
2040:
1999:
1958:
1899:
1850:
1841:
1824:
1801:
1792:
1775:
1757:
1748:
1731:
1716:
1665:
2126:
1581:
1273:
1268:
1864:
Lin Q, Liu Y, Moore DJ, Elizer SK, Veach RA, Hawiger J, Ruley HE (2012).
1397:
distribution of Bcl10 and CARD-CC proteins indicate a conserved complex.
1374:
1343:
1316:
1257:
1104:
1085:
1386:
1289:
1071:
1026:
71:
2721:
Gaide O, Martinon F, Micheau O, Bonnet D, Thome M, Tschopp J (2001).
1426:
1420:
1414:
1363:
1359:
1355:
1241:
981:
1377:
and has been shown to be functionally conserved all the way back to
2312:
Apostolou S, De Rienzo A, Murthy SS, Jhanwar SC, Testa JR (1999).
1455:
1449:
1443:
1437:
1432:
1370:
1351:
2253:
2240:
domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)".
944:
940:
1312:
1308:
1304:
1300:
1296:
118:
1622:"Functional characterization of zebrafish. (Danio rerio) Bcl10"
840:
positive regulation of NF-kappaB transcription factor activity
2314:"Absence of BCL10 mutations in human malignant mesothelioma"
870:
positive regulation of extrinsic apoptotic signaling pathway
865:
positive regulation of I-kappaB kinase/NF-kappaB signaling
374:
2204:
Yan M, Lee J, Schilbach S, Goddard A, Dixit V (1999).
790:
negative regulation of mature B cell apoptotic process
539:
855:
positive regulation of mast cell cytokine production
785:
stimulatory C-type lectin receptor signaling pathway
1202:
1173:
1147:
1122:
800:
positive regulation of transcription, DNA-templated
1497:
1495:
1493:
1476:
1474:
1472:
1346:. This protein is reported to interact with other
1336:mucosa-associated lymphoid tissue (MALT) lymphoma
321:
220:
1769:
1767:
770:regulation of T cell receptor signaling pathway
16:Protein-coding gene in the species Homo sapiens
1502:GRCm38: Ensembl release 89: ENSMUSG00000028191
1338:. The protein encoded by this gene contains a
2530:Poyet JL, Srinivasula SM, Alnemri ES (2001).
925:lipopolysaccharide-mediated signaling pathway
890:positive regulation of protein ubiquitination
8:
1607:"Entrez Gene: BCL10 B-cell CLL/lymphoma 10"
1481:GRCh38: Ensembl release 89: ENSG00000142867
955:
565:
362:
261:
158:
60:
2738:
2695:
2660:
2625:
2582:
2547:
2512:
2477:
2442:
2399:
2364:
2329:
2294:
2221:
2186:
2151:
2030:
1989:
1948:
1938:
1889:
1840:
1791:
1747:
1706:
1696:
1655:
1645:
1571:
1601:
1599:
915:positive regulation of apoptotic process
880:response to molecule of bacterial origin
835:positive regulation of T cell activation
820:cellular response to mechanical stimulus
1468:
845:immunoglobulin mediated immune response
930:positive regulation of kinase activity
875:positive regulation of phosphorylation
20:
1350:domain containing proteins including
805:Fc-epsilon receptor signaling pathway
326:
287:
282:
225:
184:
179:
7:
2347:Costanzo A, Guiet C, Vito P (1999).
795:toll-like receptor signaling pathway
1913:Wu CJ, Ashwell JD (February 2008).
885:I-kappaB kinase/NF-kappaB signaling
689:lipopolysaccharide receptor complex
1381:. Notably, just like the upstream
1315:, it has clinical significance in
1199:
1170:
1144:
1119:
1095:
1076:
1050:
1031:
1005:
986:
583:transcription coactivator activity
544:
462:
400:
379:
14:
1342:, and has been shown to activate
1340:caspase recruitment domain (CARD)
1292:that in humans is encoded by the
895:T cell receptor signaling pathway
643:ubiquitin protein ligase binding
310:
303:
297:
274:
209:
202:
196:
171:
850:protein complex oligomerization
755:regulation of apoptotic process
699:perinuclear region of cytoplasm
528:More reference expression data
1:
2740:10.1016/S0014-5793(01)02414-0
2584:10.1016/S0092-8674(01)00189-1
2514:10.1016/S1097-2765(05)00086-9
2435:10.1016/S0002-9440(10)64630-5
2331:10.1016/S0092-8674(02)09765-9
1991:10.1016/S1097-2765(05)00086-9
1573:10.1016/S0092-8674(00)80957-5
920:protein heterooligomerization
295:
194:
1919:Proc. Natl. Acad. Sci. U.S.A
1647:10.1371/journal.pone.0122365
588:transcription factor binding
2775:Genes on human chromosome 1
1286:B-cell lymphoma/leukemia 10
900:protein homooligomerization
2801:
2068:gene details page in the
729:protein-containing complex
618:protein C-terminus binding
1537:"Mouse PubMed Reference:"
1519:"Human PubMed Reference:"
1272:
1267:
1263:
1256:
1240:
1234:Chr 3: 145.63 β 145.64 Mb
1221:
1206:
1177:
1166:
1151:
1126:
1115:
1102:
1098:
1083:
1079:
1070:
1057:
1053:
1038:
1034:
1025:
1012:
1008:
993:
989:
980:
965:
958:
954:
938:
810:cellular defense response
648:identical protein binding
628:kinase activator activity
568:
564:
552:
547:
538:
525:
474:
465:
432:epithelium of nasopharynx
412:
403:
373:
365:
361:
344:
331:
294:
273:
264:
260:
243:
230:
193:
170:
161:
157:
112:
109:
99:
92:
87:
68:
63:
46:
41:
36:
32:
28:
23:
2401:10.1074/jbc.275.15.11114
2366:10.1074/jbc.274.29.20127
2296:10.1074/jbc.274.25.17946
2223:10.1074/jbc.274.15.10287
2032:10.1074/jbc.275.15.11114
1882:10.4049/jimmunol.1101502
1698:10.3389/fimmu.2018.01136
1405:BCL10 has been shown to
765:B cell apoptotic process
760:adaptive immune response
750:T cell apoptotic process
608:protein self-association
593:protein kinase B binding
2188:10.1074/jbc.274.15.9962
2153:10.1074/jbc.274.15.9955
1940:10.1073/pnas.0712313105
1685:Frontiers in Immunology
1227:Chr 1: 85.27 β 85.28 Mb
709:cytoplasmic microtubule
684:T cell receptor complex
416:mucosa of sigmoid colon
2785:Tumor suppressor genes
2697:10.1074/jbc.M010512200
2662:10.1074/jbc.M009984200
2627:10.1074/jbc.M102488200
2549:10.1074/jbc.C000792200
2479:10.1074/jbc.C000726200
2098:10.1038/sj.thj.6200146
1842:10.1074/jbc.C000726200
1793:10.1074/jbc.M010512200
1749:10.1074/jbc.M102488200
1330:was identified by its
910:protein ubiquitination
905:innate immune response
638:protein kinase binding
1393:, and the correlated
1385:, Bcl10 is absent in
775:immune system process
694:immunological synapse
498:stroma of bone marrow
436:palpebral conjunctiva
2062:genome location and
1348:CARD and coiled coil
289:Chromosome 3 (mouse)
187:Chromosome 1 (human)
64:List of PDB id codes
37:Available structures
2690:(15): 11877β11882.
2655:(22): 19012β19019.
2620:(24): 21405β21409.
2472:(52): 41082β41086.
2394:(15): 11114β11120.
2359:(29): 20127β20132.
2289:(25): 17946β17954.
2216:(15): 10287β10292.
2070:UCSC Genome Browser
1931:2008PNAS..105.3023W
1638:2015PLoSO..1022365M
825:neural tube closure
653:CARD domain binding
440:germinal epithelium
424:gingival epithelium
1060:ENSMUSG00000028191
830:response to fungus
738:Biological process
662:Cellular component
576:Molecular function
2181:(15): 9962β9968.
2146:(15): 9955β9961.
1283:
1282:
1279:
1278:
1252:
1251:
1217:
1216:
1196:
1195:
1162:
1161:
1141:
1140:
1111:
1110:
1092:
1091:
1066:
1065:
1047:
1046:
1021:
1020:
1002:
1001:
950:
949:
745:apoptotic process
598:NF-kappaB binding
560:
559:
556:
555:
534:
533:
521:
520:
459:
458:
357:
356:
256:
255:
151:BCL10 - orthologs
83:
82:
79:
78:
47:Ortholog search:
2792:
2760:
2742:
2733:(2β3): 121β127.
2717:
2699:
2674:
2664:
2639:
2629:
2604:
2586:
2561:
2551:
2542:(5): 3183β3187.
2526:
2516:
2491:
2481:
2456:
2446:
2429:(4): 1147β1154.
2413:
2403:
2378:
2368:
2343:
2333:
2308:
2298:
2273:
2235:
2225:
2200:
2190:
2165:
2155:
2130:
2121:(19): 4297β301.
2109:
2045:
2044:
2034:
2025:(15): 11114β20.
2010:
2004:
2003:
1993:
1969:
1963:
1962:
1952:
1942:
1910:
1904:
1903:
1893:
1861:
1855:
1854:
1844:
1820:
1814:
1813:
1795:
1786:(15): 11877β82.
1771:
1762:
1761:
1751:
1727:
1721:
1720:
1710:
1700:
1676:
1670:
1669:
1659:
1649:
1617:
1611:
1610:
1603:
1594:
1593:
1575:
1551:
1545:
1544:
1533:
1527:
1526:
1515:
1509:
1499:
1488:
1478:
1265:
1264:
1236:
1229:
1212:
1200:
1191:
1171:
1167:RefSeq (protein)
1157:
1145:
1136:
1120:
1096:
1077:
1051:
1032:
1006:
987:
956:
860:response to food
603:protease binding
566:
545:
530:
506:Ileal epithelium
470:
468:Top expressed in
463:
428:secondary oocyte
408:
406:Top expressed in
401:
380:
363:
353:
340:
329:
314:
307:
301:
290:
278:
262:
252:
239:
228:
213:
206:
200:
189:
175:
159:
153:
104:
97:
74:
61:
55:
34:
33:
21:
2800:
2799:
2795:
2794:
2793:
2791:
2790:
2789:
2765:
2764:
2763:
2720:
2677:
2642:
2607:
2564:
2529:
2494:
2459:
2416:
2381:
2346:
2311:
2276:
2238:
2203:
2168:
2133:
2112:
2083:
2079:
2077:Further reading
2053:
2048:
2012:
2011:
2007:
1971:
1970:
1966:
1912:
1911:
1907:
1863:
1862:
1858:
1835:(52): 41082β6.
1822:
1821:
1817:
1773:
1772:
1765:
1742:(24): 21405β9.
1729:
1728:
1724:
1678:
1677:
1673:
1632:(4): e0122365.
1619:
1618:
1614:
1605:
1604:
1597:
1553:
1552:
1548:
1535:
1534:
1530:
1517:
1516:
1512:
1500:
1491:
1479:
1470:
1466:
1461:
1403:
1325:
1274:View/Edit Mouse
1269:View/Edit Human
1232:
1225:
1222:Location (UCSC)
1208:
1187:
1183:
1179:
1153:
1132:
1128:
1041:ENSG00000142867
934:
733:
657:
623:protein binding
526:
517:
514:renal corpuscle
512:
508:
504:
500:
496:
492:
488:
484:
480:
466:
455:
450:
446:
442:
438:
434:
430:
426:
422:
418:
404:
348:
335:
327:
317:
316:
315:
308:
288:
265:Gene location (
247:
234:
226:
216:
215:
214:
207:
185:
162:Gene location (
113:
100:
93:
70:
48:
17:
12:
11:
5:
2798:
2796:
2788:
2787:
2782:
2777:
2767:
2766:
2762:
2761:
2718:
2675:
2640:
2605:
2562:
2527:
2507:(4): 961β967.
2492:
2457:
2414:
2379:
2344:
2324:(6): 684β686.
2309:
2274:
2236:
2201:
2166:
2131:
2110:
2080:
2078:
2075:
2074:
2073:
2052:
2051:External links
2049:
2047:
2046:
2005:
1964:
1905:
1856:
1815:
1763:
1722:
1671:
1612:
1595:
1546:
1528:
1510:
1489:
1467:
1465:
1462:
1460:
1459:
1453:
1447:
1441:
1435:
1430:
1424:
1418:
1411:
1402:
1399:
1383:CARD-CC family
1324:
1321:
1281:
1280:
1277:
1276:
1271:
1261:
1260:
1254:
1253:
1250:
1249:
1247:
1245:
1238:
1237:
1230:
1223:
1219:
1218:
1215:
1214:
1204:
1203:
1197:
1194:
1193:
1189:NP_001307644.1
1175:
1174:
1168:
1164:
1163:
1160:
1159:
1149:
1148:
1142:
1139:
1138:
1124:
1123:
1117:
1113:
1112:
1109:
1108:
1100:
1099:
1093:
1090:
1089:
1081:
1080:
1074:
1068:
1067:
1064:
1063:
1055:
1054:
1048:
1045:
1044:
1036:
1035:
1029:
1023:
1022:
1019:
1018:
1010:
1009:
1003:
1000:
999:
991:
990:
984:
978:
977:
972:
967:
963:
962:
952:
951:
948:
947:
936:
935:
933:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
741:
739:
735:
734:
732:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
671:
665:
663:
659:
658:
656:
655:
650:
645:
640:
635:
633:enzyme binding
630:
625:
620:
615:
613:kinase binding
610:
605:
600:
595:
590:
585:
579:
577:
573:
572:
562:
561:
558:
557:
554:
553:
550:
549:
542:
536:
535:
532:
531:
523:
522:
519:
518:
516:
515:
511:
507:
503:
499:
495:
491:
487:
483:
479:
475:
472:
471:
460:
457:
456:
454:
453:
452:jejunal mucosa
449:
445:
444:amniotic fluid
441:
437:
433:
429:
425:
421:
417:
413:
410:
409:
397:
396:
388:
377:
371:
370:
367:RNA expression
359:
358:
355:
354:
346:
342:
341:
333:
330:
325:
319:
318:
309:
302:
296:
292:
291:
286:
280:
279:
271:
270:
258:
257:
254:
253:
245:
241:
240:
232:
229:
224:
218:
217:
208:
201:
195:
191:
190:
183:
177:
176:
168:
167:
155:
154:
111:
107:
106:
98:
90:
89:
85:
84:
81:
80:
77:
76:
66:
65:
57:
56:
45:
39:
38:
30:
29:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
2797:
2786:
2783:
2781:
2778:
2776:
2773:
2772:
2770:
2758:
2754:
2750:
2746:
2741:
2736:
2732:
2728:
2724:
2719:
2715:
2711:
2707:
2703:
2698:
2693:
2689:
2685:
2684:J. Biol. Chem
2681:
2676:
2672:
2668:
2663:
2658:
2654:
2650:
2649:J. Biol. Chem
2646:
2641:
2637:
2633:
2628:
2623:
2619:
2615:
2614:J. Biol. Chem
2611:
2606:
2602:
2598:
2594:
2590:
2585:
2580:
2576:
2572:
2568:
2563:
2559:
2555:
2550:
2545:
2541:
2537:
2536:J. Biol. Chem
2533:
2528:
2524:
2520:
2515:
2510:
2506:
2502:
2498:
2493:
2489:
2485:
2480:
2475:
2471:
2467:
2466:J. Biol. Chem
2463:
2458:
2454:
2450:
2445:
2440:
2436:
2432:
2428:
2424:
2423:Am. J. Pathol
2420:
2415:
2411:
2407:
2402:
2397:
2393:
2389:
2388:J. Biol. Chem
2385:
2380:
2376:
2372:
2367:
2362:
2358:
2354:
2353:J. Biol. Chem
2350:
2345:
2341:
2337:
2332:
2327:
2323:
2319:
2315:
2310:
2306:
2302:
2297:
2292:
2288:
2284:
2283:J. Biol. Chem
2280:
2275:
2271:
2267:
2263:
2259:
2255:
2251:
2247:
2243:
2237:
2233:
2229:
2224:
2219:
2215:
2211:
2210:J. Biol. Chem
2207:
2202:
2198:
2194:
2189:
2184:
2180:
2176:
2175:J. Biol. Chem
2172:
2167:
2163:
2159:
2154:
2149:
2145:
2141:
2140:J. Biol. Chem
2137:
2132:
2128:
2124:
2120:
2116:
2111:
2107:
2103:
2099:
2095:
2091:
2087:
2082:
2081:
2076:
2071:
2067:
2066:
2061:
2060:
2055:
2054:
2050:
2042:
2038:
2033:
2028:
2024:
2020:
2019:J. Biol. Chem
2016:
2009:
2006:
2001:
1997:
1992:
1987:
1983:
1979:
1975:
1968:
1965:
1960:
1956:
1951:
1946:
1941:
1936:
1932:
1928:
1925:(8): 3023β8.
1924:
1920:
1916:
1909:
1906:
1901:
1897:
1892:
1887:
1883:
1879:
1876:(6): 2493β7.
1875:
1871:
1867:
1860:
1857:
1852:
1848:
1843:
1838:
1834:
1830:
1829:J. Biol. Chem
1826:
1819:
1816:
1811:
1807:
1803:
1799:
1794:
1789:
1785:
1781:
1780:J. Biol. Chem
1777:
1770:
1768:
1764:
1759:
1755:
1750:
1745:
1741:
1737:
1736:J. Biol. Chem
1733:
1726:
1723:
1718:
1714:
1709:
1704:
1699:
1694:
1690:
1686:
1682:
1675:
1672:
1667:
1663:
1658:
1653:
1648:
1643:
1639:
1635:
1631:
1627:
1623:
1616:
1613:
1608:
1602:
1600:
1596:
1591:
1587:
1583:
1579:
1574:
1569:
1565:
1561:
1557:
1550:
1547:
1542:
1538:
1532:
1529:
1524:
1520:
1514:
1511:
1507:
1503:
1498:
1496:
1494:
1490:
1486:
1482:
1477:
1475:
1473:
1469:
1463:
1457:
1454:
1451:
1448:
1445:
1442:
1439:
1436:
1434:
1431:
1428:
1425:
1422:
1419:
1416:
1413:
1412:
1410:
1408:
1400:
1398:
1396:
1392:
1388:
1384:
1380:
1376:
1372:
1369:
1365:
1361:
1357:
1353:
1349:
1345:
1341:
1337:
1334:in a case of
1333:
1332:translocation
1329:
1322:
1320:
1318:
1314:
1311:, BCL7A, and
1310:
1306:
1302:
1298:
1295:
1291:
1287:
1275:
1270:
1266:
1262:
1259:
1255:
1248:
1246:
1243:
1239:
1235:
1231:
1228:
1224:
1220:
1213:
1211:
1205:
1201:
1198:
1192:
1190:
1186:
1182:
1176:
1172:
1169:
1165:
1158:
1156:
1150:
1146:
1143:
1137:
1135:
1131:
1125:
1121:
1118:
1116:RefSeq (mRNA)
1114:
1107:
1106:
1101:
1097:
1094:
1088:
1087:
1082:
1078:
1075:
1073:
1069:
1062:
1061:
1056:
1052:
1049:
1043:
1042:
1037:
1033:
1030:
1028:
1024:
1017:
1016:
1011:
1007:
1004:
998:
997:
992:
988:
985:
983:
979:
976:
973:
971:
968:
964:
961:
957:
953:
946:
942:
937:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
893:
891:
888:
886:
883:
881:
878:
876:
873:
871:
868:
866:
863:
861:
858:
856:
853:
851:
848:
846:
843:
841:
838:
836:
833:
831:
828:
826:
823:
821:
818:
816:
813:
811:
808:
806:
803:
801:
798:
796:
793:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
761:
758:
756:
753:
751:
748:
746:
743:
742:
740:
737:
736:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
704:membrane raft
702:
700:
697:
695:
692:
690:
687:
685:
682:
680:
677:
675:
672:
670:
667:
666:
664:
661:
660:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
599:
596:
594:
591:
589:
586:
584:
581:
580:
578:
575:
574:
571:
570:Gene ontology
567:
563:
551:
546:
543:
541:
537:
529:
524:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
476:
473:
469:
464:
461:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
414:
411:
407:
402:
399:
398:
395:
393:
389:
387:
386:
382:
381:
378:
376:
372:
368:
364:
360:
352:
347:
343:
339:
334:
324:
320:
313:
306:
300:
293:
285:
281:
277:
272:
268:
263:
259:
251:
246:
242:
238:
233:
223:
219:
212:
205:
199:
192:
188:
182:
178:
174:
169:
165:
160:
156:
152:
148:
144:
140:
136:
132:
128:
124:
120:
116:
108:
103:
96:
91:
86:
75:
73:
67:
62:
59:
58:
54:
51:
44:
40:
35:
31:
27:
22:
19:
2730:
2726:
2687:
2683:
2652:
2648:
2617:
2613:
2577:(1): 33β42.
2574:
2570:
2539:
2535:
2504:
2500:
2469:
2465:
2426:
2422:
2391:
2387:
2356:
2352:
2321:
2317:
2286:
2282:
2254:10.1038/8767
2248:(1): 63β68.
2245:
2241:
2213:
2209:
2178:
2174:
2143:
2139:
2118:
2114:
2089:
2085:
2064:
2058:
2022:
2018:
2008:
1984:(4): 961β7.
1981:
1977:
1967:
1922:
1918:
1908:
1873:
1869:
1859:
1832:
1828:
1818:
1783:
1779:
1739:
1735:
1725:
1688:
1684:
1674:
1629:
1625:
1615:
1566:(1): 35β45.
1563:
1559:
1549:
1540:
1531:
1522:
1513:
1404:
1401:Interactions
1395:phylogenetic
1327:
1326:
1293:
1285:
1284:
1207:
1181:NP_001307644
1178:
1152:
1134:NM_001320715
1127:
1103:
1084:
1058:
1039:
1013:
994:
974:
969:
502:cumulus cell
494:otic vesicle
482:otic placode
390:
383:
349:145,640,111
336:145,628,559
110:External IDs
69:
18:
2092:(1): 10β3.
1368:paracaspase
724:CBM complex
490:Paneth cell
486:granulocyte
328:3|3 H2
248:85,276,632
235:85,265,776
88:Identifiers
2769:Categories
2242:Nat. Genet
2115:Cancer Res
2086:Hematol. J
1870:J. Immunol
1508:, May 2017
1487:, May 2017
1464:References
780:cell death
394:(ortholog)
131:HomoloGene
2727:FEBS Lett
2501:Mol. Cell
1978:Mol. Cell
1391:nematodes
1379:zebrafish
1210:NP_033870
1185:NP_003912
1155:NM_009740
1130:NM_003921
960:Orthologs
669:cytoplasm
139:GeneCards
2780:Proteins
2757:22024213
2749:11356195
2714:35815019
2706:11278692
2671:11262391
2636:11259443
2593:11163238
2558:11113112
2523:11090634
2488:11053425
2453:11021819
2410:10753917
2375:10400625
2340:10380921
2305:10364242
2262:10319863
2232:10187815
2197:10187771
2162:10187770
2106:11960389
2041:10753917
2000:11090634
1959:18287044
1900:22323537
1851:11053425
1810:35815019
1802:11278692
1758:11259443
1717:29881386
1691:: 1136.
1666:25849213
1626:PLOS ONE
1504:–
1483:–
1407:interact
1375:cnidaria
1323:Function
1317:lymphoma
1307:, BCL5,
1258:Wikidata
939:Sources:
714:lysosome
679:membrane
2601:9100379
2444:1850175
2270:1858018
2127:8813110
1950:2268578
1927:Bibcode
1891:3294148
1708:5978004
1657:4388727
1634:Bibcode
1590:1613152
1582:9989495
1506:Ensembl
1485:Ensembl
1387:insects
1299:. Like
1290:protein
1072:UniProt
1027:Ensembl
966:Species
945:QuickGO
719:nucleus
674:cytosol
478:saccule
369:pattern
127:1337994
95:Aliases
2755:
2747:
2712:
2704:
2669:
2634:
2599:
2591:
2556:
2521:
2486:
2451:
2441:
2408:
2373:
2338:
2303:
2268:
2260:
2230:
2195:
2160:
2125:
2104:
2056:Human
2039:
1998:
1957:
1947:
1898:
1888:
1849:
1808:
1800:
1756:
1715:
1705:
1664:
1654:
1588:
1580:
1452:, and
1427:CARD14
1421:CARD11
1415:CARD10
1409:with:
1244:search
1242:PubMed
1105:Q9Z0H7
1086:O95999
982:Entrez
540:BioGPS
420:oocyte
227:1p22.3
119:603517
2753:S2CID
2710:S2CID
2597:S2CID
2266:S2CID
2065:BCL10
2059:BCL10
1806:S2CID
1586:S2CID
1456:TRAF2
1450:MALT1
1444:IKBKG
1438:CRADD
1433:CARD9
1371:MALT1
1352:CARD9
1344:NF-ΞΊB
1328:Bcl10
1294:BCL10
1288:is a
1015:12042
975:Mouse
970:Human
941:Amigo
510:blood
448:tibia
392:Mouse
385:Human
332:Start
267:Mouse
231:Start
164:Human
143:BCL10
102:BCL10
24:BCL10
2745:PMID
2702:PMID
2667:PMID
2632:PMID
2589:PMID
2571:Cell
2554:PMID
2519:PMID
2484:PMID
2449:PMID
2406:PMID
2371:PMID
2336:PMID
2318:Cell
2301:PMID
2258:PMID
2228:PMID
2193:PMID
2158:PMID
2123:PMID
2102:PMID
2037:PMID
1996:PMID
1955:PMID
1896:PMID
1847:PMID
1798:PMID
1754:PMID
1713:PMID
1662:PMID
1578:PMID
1560:Cell
1389:and
1362:and
1313:BCL9
1309:BCL6
1305:BCL3
1301:BCL2
1297:gene
996:8915
375:Bgee
323:Band
284:Chr.
222:Band
181:Chr.
135:2912
115:OMIM
72:2MB9
53:RCSB
50:PDBe
2735:doi
2731:496
2692:doi
2688:276
2657:doi
2653:276
2622:doi
2618:276
2579:doi
2575:104
2544:doi
2540:276
2509:doi
2474:doi
2470:275
2439:PMC
2431:doi
2427:157
2396:doi
2392:275
2361:doi
2357:274
2326:doi
2291:doi
2287:274
2250:doi
2218:doi
2214:274
2183:doi
2179:274
2148:doi
2144:274
2094:doi
2027:doi
2023:275
1986:doi
1945:PMC
1935:doi
1923:105
1886:PMC
1878:doi
1874:188
1837:doi
1833:275
1788:doi
1784:276
1744:doi
1740:276
1703:PMC
1693:doi
1652:PMC
1642:doi
1568:doi
1364:-14
1360:-11
1356:-10
548:n/a
345:End
244:End
147:OMA
123:MGI
43:PDB
2771::
2751:.
2743:.
2729:.
2725:.
2708:.
2700:.
2686:.
2682:.
2665:.
2651:.
2647:.
2630:.
2616:.
2612:.
2595:.
2587:.
2573:.
2569:.
2552:.
2538:.
2534:.
2517:.
2503:.
2499:.
2482:.
2468:.
2464:.
2447:.
2437:.
2425:.
2421:.
2404:.
2390:.
2386:.
2369:.
2355:.
2351:.
2334:.
2322:97
2320:.
2316:.
2299:.
2285:.
2281:.
2264:.
2256:.
2246:22
2244:.
2226:.
2212:.
2208:.
2191:.
2177:.
2173:.
2156:.
2142:.
2138:.
2119:56
2117:.
2100:.
2088:.
2035:.
2021:.
2017:.
1994:.
1980:.
1976:.
1953:.
1943:.
1933:.
1921:.
1917:.
1894:.
1884:.
1872:.
1868:.
1845:.
1831:.
1827:.
1804:.
1796:.
1782:.
1778:.
1766:^
1752:.
1738:.
1734:.
1711:.
1701:.
1687:.
1683:.
1660:.
1650:.
1640:.
1630:10
1628:.
1624:.
1598:^
1584:.
1576:.
1564:96
1562:.
1558:.
1539:.
1521:.
1492:^
1471:^
1358:,
1354:,
1319:.
1303:,
943:/
351:bp
338:bp
250:bp
237:bp
145:;
141::
137:;
133::
129:;
125::
121:;
117::
2759:.
2737::
2716:.
2694::
2673:.
2659::
2638:.
2624::
2603:.
2581::
2560:.
2546::
2525:.
2511::
2505:6
2490:.
2476::
2455:.
2433::
2412:.
2398::
2377:.
2363::
2342:.
2328::
2307:.
2293::
2272:.
2252::
2234:.
2220::
2199:.
2185::
2164:.
2150::
2129:.
2108:.
2096::
2090:3
2072:.
2043:.
2029::
2002:.
1988::
1982:6
1961:.
1937::
1929::
1902:.
1880::
1853:.
1839::
1812:.
1790::
1760:.
1746::
1719:.
1695::
1689:9
1668:.
1644::
1636::
1609:.
1592:.
1570::
1543:.
1525:.
1458:.
1446:,
1440:,
1429:,
1423:,
1417:,
269:)
166:)
149::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
