353:
330:
227:
252:
3318:
2371:
2386:
611:
2356:
604:
359:
258:
40:
2326:
2401:
2341:
1187:
1170:
yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene
2234:
66:
1361:
ENSG00000239754, ENSG00000243649, ENSG00000241253, ENSG00000242335, ENSG00000241534, ENSG00000204359 GRCh38: Ensembl release 89: ENSG00000243570, ENSG00000239754, ENSG00000243649, ENSG00000241253, ENSG00000242335, ENSG00000241534,
1751:
Yancey KB, Overholser O, Domloge-Hultsch N, Li LJ, Caughman SW, Bisalbutra P (March 1992). "Human keratinocytes and A-431 cells synthesize and secrete factor B, the major zymogen protease of the alternative complement pathway".
2370:
1183:. This cluster includes several genes involved in regulation of the immune reaction. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
2385:
2035:"Amino acid sequence of the Bb fragment from complement Factor B. Sequence of the major cyanogen bromide-cleavage peptide (CB-II) and completion of the sequence of the Bb fragment"
1900:
Wu LC, Morley BJ, Campbell RD (January 1987). "Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements".
3268:
1667:
Arnason A, Larsen B, Marshall WH, Edwards JH, Macintosh P, Olaisen B, Teisberg P (August 1977). "Very close linkage between HLA-B and Bf inferred from allelic association".
3128:
366:
265:
2868:
2441:
839:
188:
820:
3359:
1166:
activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement
2164:
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
2355:
1296:
2305:
1417:
3378:
1399:
1250:
1714:"Production and interferon-gamma-mediated regulation of complement component C2 and factors B and D by the astroglioma cell line U105-MG"
352:
2861:
2655:
1084:
1077:
329:
1172:
1438:
2434:
2113:"Isolation of cDNA clones for the human complement protein factor B, a class III major histocompatibility complex gene product"
1859:"Analysis of the interaction between properdin and factor B, components of the alternative-pathway C3 convertase of complement"
1386:
1365:
2854:
2474:
1217:
1159:
1382:
251:
226:
63:
2193:
Mejía JE, Jahn I, de la Salle H, Hauptmann G (January 1994). "Human factor B. Complete cDNA sequence of the BF*S allele".
1360:
3352:
3088:
2464:
2325:
1315:
1207:
168:
2846:
3383:
2427:
365:
264:
159:, Cfb, AI195813, AI255840, Bf, C2, Fb, H2-Bf, AHUS4, ARMD14, BFD, CFAB, CFBD, FBI12, GBG, PBF2, complement factor B
2400:
3003:
2988:
2888:
2710:
2298:
1228:
358:
257:
3388:
2885:
2253:
910:
176:
2340:
3345:
3278:
3243:
3238:
2790:
2660:
2625:
2620:
2515:
2510:
2505:
1277:
891:
887:
877:
873:
869:
865:
861:
2680:
2670:
2665:
2615:
2594:
2539:
2522:
1992:"Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen"
1820:
Davrinche C, Abbal M, Clerc A (1991). "Molecular characterization of human complement factor B subtypes".
1223:
1203:
3233:
3083:
2762:
2757:
2558:
1273:
2379:: Crystal Structure Analysis of the Bb segment of Factor B complexed with Di-isopropyl-phosphate (DIP)
3223:
2772:
2767:
2291:
2124:
1950:
1676:
1573:
1180:
240:
155:
3123:
2930:
2925:
2749:
2729:
2719:
1060:
1052:
1001:
2394:: Crystal Structure Analysis of the Bb segment of Factor B complexed with 4-guanidinobenzoic acid
1939:"Molecular cloning and characterization of the gene coding for human complement protein factor B"
1925:
1845:
1700:
1626:
200:
3317:
1056:
1031:
1005:
980:
2249:
3105:
2450:
2260:
2210:
2181:
2152:
2099:
2064:
2021:
1978:
1917:
1888:
1837:
1808:
1769:
1739:
1692:
1655:
1618:
1589:
1552:
1523:
1480:
1195:
1163:
148:
56:
2897:
2824:
2777:
2599:
2202:
2173:
2142:
2132:
2089:
2054:
2046:
2011:
2003:
1968:
1958:
1909:
1878:
1870:
1829:
1798:
1790:
1761:
1729:
1721:
1684:
1647:
1610:
1581:
1544:
1513:
1505:
1470:
445:
376:
320:
275:
2244:
610:
3138:
3133:
2905:
2881:
2553:
2549:
1535:
Campbell RD (January 1987). "The molecular genetics and polymorphism of C2 and factor B".
420:
1638:
Rawal N, Pangburn MK (March 2001). "Structure/function of C5 convertases of complement".
196:
2128:
1954:
1680:
1577:
1566:
Philosophical
Transactions of the Royal Society of London. Series B, Biological Sciences
603:
3329:
2469:
2059:
2034:
2007:
1883:
1858:
1803:
1782:
1734:
1713:
1548:
1518:
1493:
2147:
2112:
2094:
2077:
2016:
1991:
1973:
1938:
1651:
754:
749:
744:
739:
734:
729:
713:
708:
703:
698:
693:
677:
672:
667:
662:
657:
652:
3372:
3283:
3156:
3145:
2877:
2639:
2634:
2269:
2206:
2177:
1913:
1176:
639:
1929:
1849:
1630:
39:
3179:
3073:
2915:
2835:
2830:
2818:
2800:
2795:
2705:
1704:
1334:
1254:
438:
217:
180:
1564:
Campbell RD, Bentley DR, Morley BJ (September 1984). "The factor B and C2 genes".
1459:"The Ba fragment of complement factor B inhibits human B lymphocyte proliferation"
1186:
1765:
204:
3298:
3293:
2942:
1475:
1458:
1422:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1404:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2117:
Proceedings of the
National Academy of Sciences of the United States of America
1943:
Proceedings of the
National Academy of Sciences of the United States of America
521:
3260:
3202:
2983:
2978:
2958:
2675:
2500:
2229:
337:
234:
184:
1601:
Yu CY (1999). "Molecular genetics of the human MHC complement gene cluster".
3325:
3288:
3274:
3093:
2973:
2963:
2578:
2137:
1963:
784:
581:
459:
404:
391:
303:
290:
192:
17:
2111:
Woods DE, Markham AF, Ricker AT, Goldberger G, Colten HR (September 1982).
1659:
1622:
1585:
1527:
2214:
2185:
2156:
2103:
2068:
2025:
1982:
1921:
1892:
1841:
1812:
1773:
1743:
1593:
1556:
1484:
1124:
1119:
3174:
3169:
3118:
2968:
2953:
2920:
2739:
2573:
2078:"Complete primary structure for the zymogen of human complement factor B"
1696:
1167:
1108:
955:
936:
1509:
3228:
3218:
3164:
3078:
2910:
2274:
2264:
1833:
1140:
922:
851:
2050:
1874:
1794:
1725:
1614:
125:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
3255:
3197:
2240:
1688:
1494:"Complement in age-related macular degeneration: a focus on function"
1092:
806:
2419:
2230:
GeneReviews/NCBI/NIH/UW entry on
Atypical Hemolytic-Uremic Syndrome
3264:
3250:
3189:
3063:
3058:
3053:
3048:
3043:
3038:
2781:
1185:
769:
765:
3033:
3028:
3023:
3018:
3013:
3008:
2998:
2993:
2785:
2714:
2608:
1147:
172:
2850:
2423:
2287:
2604:
2532:
2527:
2283:
1783:"The principal site of glycation of human complement factor B"
619:
2259:
Overview of all the structural information available in the
1712:
Barnum SR, Ishii Y, Agrawal A, Volanakis JE (October 1992).
2364:: Crystal Structure Analysis of the Bb segment of Factor B
1158:
This gene encodes complement factor B, a component of the
2076:
Mole JE, Anderson JK, Davison EA, Woods DE (March 1984).
428:
3333:
1457:
Ambrus JL, Peters MG, Fauci AS, Brown EJ (March 1990).
2243:
online database for peptidases and their inhibitors:
593:
1857:
Farries TC, Lachmann PJ, Harrison RA (August 1988).
3211:
3188:
3154:
3104:
2941:
2896:
2811:
2748:
2695:
2648:
2587:
2490:
2483:
2457:
1045:
1024:
994:
973:
2235:OMIM entries on Atypical Hemolytic-Uremic Syndrome
1378:
1376:
1374:
1356:
1354:
1352:
1190:Alternative pathway. (Some labels are in Polish.)
375:
274:
27:Protein-coding gene in the species Homo sapiens
1781:Niemann MA, Bhown AS, Miller EJ (March 1991).
1492:Bradley DT, Zipfel PF, Hughes AE (June 2011).
1383:GRCm38: Ensembl release 89: ENSMUSG00000090231
3353:
2862:
2435:
2299:
8:
3360:
3346:
2869:
2855:
2847:
2487:
2442:
2428:
2420:
2306:
2292:
2284:
856:
780:
750:complement activation, alternative pathway
635:
416:
315:
212:
74:
2252:at the U.S. National Library of Medicine
2146:
2136:
2093:
2058:
2015:
1972:
1962:
1882:
1802:
1733:
1517:
1474:
1754:The Journal of Investigative Dermatology
1603:Experimental and Clinical Immunogenetics
1433:
1431:
2321:
1990:Morley BJ, Campbell RD (January 1984).
1348:
2882:serine proteases/serine endopeptidases
2033:Christie DL, Gagnon J (January 1983).
1439:"Entrez Gene: CFB complement factor B"
29:
380:
341:
336:
279:
238:
233:
7:
3314:
3312:
1937:Campbell RD, Porter RR (July 1983).
2082:The Journal of Biological Chemistry
735:regulation of complement activation
2008:10.1002/j.1460-2075.1984.tb01776.x
1549:10.1093/oxfordjournals.bmb.a072175
1042:
1021:
991:
970:
946:
927:
901:
830:
811:
663:serine-type endopeptidase activity
598:
516:
454:
433:
25:
2334:: FACTOR B SERINE PROTEASE DOMAIN
1720:. 287. 287 ( Pt 2) (2): 595–601.
1143:that in humans is encoded by the
3316:
2399:
2384:
2369:
2354:
2339:
2324:
1789:. 274. 274 ( Pt 2) (2): 473–80.
1640:International Immunopharmacology
1173:major histocompatibility complex
609:
602:
364:
357:
351:
328:
263:
256:
250:
225:
38:
658:serine-type peptidase activity
620:More reference expression data
582:More reference expression data
490:olfactory zone of nasal mucosa
1:
3094:Urinary plasminogen activator
2273:(Complement factor B) at the
2095:10.1016/S0021-9258(17)43108-5
1652:10.1016/S1567-5769(00)00039-4
349:
248:
3332:. You can help Knowledge by
3089:Tissue plasminogen activator
2207:10.1016/0198-8859(94)90100-7
2178:10.1016/0378-1119(94)90802-8
1914:10.1016/0092-8674(87)90436-3
1766:10.1111/1523-1747.ep12499812
3379:Genes on human chromosome 6
2409:: Human Complement factor B
1476:10.4049/jimmunol.144.5.1549
3405:
3311:
3180:Proteinase 3/Myeloblastin
2711:Decay-accelerating factor
2319:
1418:"Mouse PubMed Reference:"
1400:"Human PubMed Reference:"
1123:
1118:
1114:
1107:
1091:
1072:
1049:
1028:
1017:
998:
977:
966:
953:
949:
934:
930:
921:
908:
904:
885:
859:
850:
837:
833:
818:
814:
805:
790:
783:
779:
763:
638:
634:
617:
601:
592:
579:
528:
519:
494:Descending thoracic aorta
466:
457:
427:
419:
415:
398:
385:
348:
327:
318:
314:
297:
284:
247:
224:
215:
211:
166:
163:
153:
146:
141:
82:
77:
60:
55:
50:
46:
37:
32:
2254:Medical Subject Headings
1537:British Medical Bulletin
1085:Chr 17: 35.08 – 35.08 Mb
2138:10.1073/pnas.79.18.5661
2039:The Biochemical Journal
1964:10.1073/pnas.80.14.4464
1863:The Biochemical Journal
1787:The Biochemical Journal
1718:The Biochemical Journal
1078:Chr 6: 31.95 – 31.95 Mb
3234:Proprotein convertases
2349:: A domain of Factor B
1586:10.1098/rstb.1984.0097
1191:
755:innate immune response
382:17 B1|17 18.41 cM
3084:Plasminogen activator
1463:Journal of Immunology
1189:
745:immune system process
730:complement activation
709:extracellular exosome
502:right coronary artery
343:Chromosome 17 (mouse)
3224:Prolyl endopeptidase
2750:Complement receptors
694:extracellular region
548:hepatobiliary system
544:white adipose tissue
241:Chromosome 6 (human)
78:List of PDB id codes
51:Available structures
2250:Complement+Factor+B
2129:1982PNAS...79.5661W
1955:1983PNAS...80.4464C
1681:1977Natur.268..527A
1578:1984RSPTB.306..367C
1510:10.1038/eye.2011.37
1199:
1160:alternative pathway
1137:Complement factor B
714:extracellular space
704:blood microparticle
486:islet of Langerhans
470:right lobe of liver
2579:Factor P/Properdin
2484:Activators/enzymes
1834:10.1007/bf00211644
1194:
1192:
911:ENSMUSG00000090231
723:Biological process
687:Cellular component
673:complement binding
668:hydrolase activity
653:peptidase activity
646:Molecular function
3384:Complement system
3341:
3340:
3309:
3308:
3106:Complement system
2898:Digestive enzymes
2844:
2843:
2691:
2690:
2451:Complement system
2417:
2416:
2051:10.1042/bj2090061
1875:10.1042/bj2530667
1795:10.1042/bj2740473
1726:10.1042/bj2870595
1615:10.1159/000019075
1340:
1339:
1171:localizes to the
1134:
1133:
1130:
1129:
1103:
1102:
1068:
1067:
1039:
1038:
1013:
1012:
988:
987:
962:
961:
943:
942:
917:
916:
898:
897:
846:
845:
827:
826:
775:
774:
630:
629:
626:
625:
588:
587:
575:
574:
513:
512:
411:
410:
310:
309:
137:
136:
133:
132:
61:Ortholog search:
16:(Redirected from
3396:
3362:
3355:
3348:
3320:
3313:
2871:
2864:
2857:
2848:
2825:immune adherence
2488:
2444:
2437:
2430:
2421:
2403:
2388:
2373:
2358:
2343:
2328:
2308:
2301:
2294:
2285:
2218:
2195:Human Immunology
2189:
2160:
2150:
2140:
2107:
2097:
2072:
2062:
2029:
2019:
1996:The EMBO Journal
1986:
1976:
1966:
1933:
1896:
1886:
1853:
1816:
1806:
1777:
1747:
1737:
1708:
1689:10.1038/268527a0
1663:
1634:
1597:
1572:(1129): 367–78.
1560:
1531:
1521:
1488:
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1443:
1442:
1435:
1426:
1425:
1414:
1408:
1407:
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1369:
1358:
1200:
1193:
1116:
1115:
1087:
1080:
1063:
1043:
1034:
1022:
1018:RefSeq (protein)
1008:
992:
983:
971:
947:
928:
902:
881:
857:
831:
812:
781:
636:
622:
613:
606:
599:
584:
524:
522:Top expressed in
517:
462:
460:Top expressed in
455:
434:
417:
407:
394:
383:
368:
361:
355:
344:
332:
316:
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207:
158:
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128:
75:
69:
48:
47:
42:
30:
21:
3404:
3403:
3399:
3398:
3397:
3395:
3394:
3393:
3389:Hydrolase stubs
3369:
3368:
3367:
3366:
3310:
3305:
3207:
3184:
3150:
3100:
2937:
2906:Enteropeptidase
2892:
2875:
2845:
2840:
2807:
2744:
2687:
2644:
2583:
2479:
2453:
2448:
2418:
2413:
2410:
2404:
2395:
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2335:
2329:
2315:
2312:
2281:
2226:
2221:
2192:
2163:
2110:
2075:
2032:
1989:
1936:
1899:
1856:
1819:
1780:
1750:
1711:
1675:(5620): 527–8.
1666:
1637:
1600:
1563:
1534:
1491:
1456:
1452:
1450:Further reading
1447:
1446:
1437:
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1429:
1416:
1415:
1411:
1398:
1397:
1393:
1381:
1372:
1362:ENSG00000204359
1359:
1350:
1345:
1156:
1125:View/Edit Mouse
1120:View/Edit Human
1083:
1076:
1073:Location (UCSC)
1059:
1055:
1051:
1030:
1004:
1000:
979:
892:ENSG00000204359
890:
888:ENSG00000241534
880:
878:ENSG00000242335
876:
874:ENSG00000241253
872:
870:ENSG00000243649
868:
866:ENSG00000239754
864:
862:ENSG00000243570
860:
759:
718:
699:plasma membrane
682:
678:protein binding
618:
608:
607:
580:
571:
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532:proximal tubule
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402:
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319:Gene location (
301:
288:
280:
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269:
268:
261:
239:
216:Gene location (
205:CFB - orthologs
167:
154:
147:
84:
62:
28:
23:
22:
15:
12:
11:
5:
3402:
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2933:
2928:
2918:
2913:
2908:
2902:
2900:
2894:
2893:
2878:Endopeptidases
2876:
2874:
2873:
2866:
2859:
2851:
2842:
2841:
2839:
2838:
2833:
2827:
2822:
2815:
2813:
2809:
2808:
2806:
2805:
2804:
2803:
2798:
2788:
2775:
2770:
2765:
2760:
2754:
2752:
2746:
2745:
2743:
2742:
2733:
2732:
2723:
2722:
2717:
2708:
2699:
2697:
2693:
2692:
2689:
2688:
2686:
2685:
2684:
2683:
2678:
2673:
2668:
2663:
2652:
2650:
2646:
2645:
2643:
2642:
2637:
2631:
2630:
2629:
2628:
2623:
2613:
2612:
2611:
2602:
2591:
2589:
2585:
2584:
2582:
2581:
2576:
2571:
2562:
2561:
2556:
2543:
2542:
2537:
2536:
2535:
2530:
2520:
2519:
2518:
2513:
2508:
2494:
2492:
2485:
2481:
2480:
2478:
2477:
2472:
2467:
2461:
2459:
2455:
2454:
2449:
2447:
2446:
2439:
2432:
2424:
2415:
2414:
2412:
2411:
2405:
2398:
2396:
2390:
2383:
2381:
2375:
2368:
2366:
2360:
2353:
2351:
2345:
2338:
2336:
2330:
2323:
2320:
2317:
2316:
2313:
2311:
2310:
2303:
2296:
2288:
2279:
2278:
2257:
2247:
2237:
2232:
2225:
2224:External links
2222:
2220:
2219:
2190:
2172:(1–2): 171–4.
2161:
2123:(18): 5661–5.
2108:
2088:(6): 3407–12.
2073:
2030:
1987:
1949:(14): 4464–8.
1934:
1897:
1854:
1822:Immunogenetics
1817:
1778:
1748:
1709:
1664:
1635:
1598:
1561:
1532:
1489:
1469:(5): 1549–53.
1453:
1451:
1448:
1445:
1444:
1427:
1409:
1391:
1370:
1347:
1346:
1344:
1341:
1338:
1337:
1332:
1329:
1326:
1323:
1319:
1318:
1313:
1310:
1307:
1304:
1300:
1299:
1294:
1291:
1288:
1285:
1281:
1280:
1271:
1268:
1265:
1262:
1258:
1257:
1248:
1245:
1242:
1239:
1235:
1234:
1231:
1226:
1221:
1211:
1155:
1152:
1132:
1131:
1128:
1127:
1122:
1112:
1111:
1105:
1104:
1101:
1100:
1098:
1096:
1089:
1088:
1081:
1074:
1070:
1069:
1066:
1065:
1047:
1046:
1040:
1037:
1036:
1026:
1025:
1019:
1015:
1014:
1011:
1010:
996:
995:
989:
986:
985:
975:
974:
968:
964:
963:
960:
959:
951:
950:
944:
941:
940:
932:
931:
925:
919:
918:
915:
914:
906:
905:
899:
896:
895:
883:
882:
854:
848:
847:
844:
843:
835:
834:
828:
825:
824:
816:
815:
809:
803:
802:
797:
792:
788:
787:
777:
776:
773:
772:
761:
760:
758:
757:
752:
747:
742:
737:
732:
726:
724:
720:
719:
717:
716:
711:
706:
701:
696:
690:
688:
684:
683:
681:
680:
675:
670:
665:
660:
655:
649:
647:
643:
642:
632:
631:
628:
627:
624:
623:
615:
614:
596:
590:
589:
586:
585:
577:
576:
573:
572:
570:
569:
565:
561:
557:
553:
549:
545:
541:
537:
533:
529:
526:
525:
514:
511:
510:
508:
507:
503:
499:
498:gastric mucosa
495:
491:
487:
483:
479:
475:
471:
467:
464:
463:
451:
450:
442:
431:
425:
424:
421:RNA expression
413:
412:
409:
408:
400:
396:
395:
387:
384:
379:
373:
372:
363:
356:
350:
346:
345:
340:
334:
333:
325:
324:
312:
311:
308:
307:
299:
295:
294:
286:
283:
278:
272:
271:
262:
255:
249:
245:
244:
237:
231:
230:
222:
221:
209:
208:
165:
161:
160:
152:
144:
143:
139:
138:
135:
134:
131:
130:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3401:
3390:
3387:
3385:
3382:
3380:
3377:
3376:
3374:
3363:
3358:
3356:
3351:
3349:
3344:
3343:
3337:
3335:
3331:
3328:article is a
3327:
3322:
3319:
3315:
3300:
3297:
3295:
3292:
3291:
3290:
3287:
3285:
3284:Streptokinase
3282:
3280:
3276:
3273:
3270:
3266:
3262:
3259:
3257:
3254:
3252:
3249:
3245:
3242:
3240:
3237:
3236:
3235:
3232:
3230:
3227:
3225:
3222:
3220:
3217:
3216:
3214:
3210:
3204:
3201:
3199:
3196:
3195:
3193:
3191:
3187:
3181:
3178:
3176:
3173:
3171:
3168:
3166:
3163:
3162:
3160:
3158:
3157:immune system
3153:
3147:
3146:C3-convertase
3144:
3140:
3137:
3135:
3132:
3131:
3130:
3127:
3125:
3122:
3120:
3117:
3115:
3112:
3111:
3109:
3107:
3103:
3095:
3092:
3090:
3087:
3086:
3085:
3082:
3080:
3077:
3075:
3071:
3070:
3065:
3062:
3060:
3057:
3055:
3052:
3050:
3047:
3045:
3042:
3040:
3037:
3035:
3032:
3030:
3027:
3025:
3022:
3020:
3017:
3015:
3012:
3010:
3007:
3005:
3002:
3000:
2997:
2995:
2992:
2990:
2987:
2986:
2985:
2982:
2980:
2977:
2975:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2949:
2948:
2946:
2944:
2940:
2932:
2929:
2927:
2924:
2923:
2922:
2919:
2917:
2914:
2912:
2909:
2907:
2904:
2903:
2901:
2899:
2895:
2890:
2887:
2883:
2879:
2872:
2867:
2865:
2860:
2858:
2853:
2852:
2849:
2837:
2834:
2832:
2828:
2826:
2823:
2820:
2817:
2816:
2814:
2810:
2802:
2799:
2797:
2794:
2793:
2792:
2791:Anaphylatoxin
2789:
2787:
2783:
2779:
2776:
2774:
2771:
2769:
2766:
2764:
2761:
2759:
2756:
2755:
2753:
2751:
2747:
2741:
2738:
2735:
2734:
2731:
2728:
2725:
2724:
2721:
2718:
2716:
2712:
2709:
2707:
2704:
2701:
2700:
2698:
2694:
2682:
2679:
2677:
2674:
2672:
2669:
2667:
2664:
2662:
2659:
2658:
2657:
2654:
2653:
2651:
2647:
2641:
2640:C5-convertase
2638:
2636:
2635:C3-convertase
2633:
2632:
2627:
2624:
2622:
2619:
2618:
2617:
2614:
2610:
2606:
2603:
2601:
2598:
2597:
2596:
2593:
2592:
2590:
2586:
2580:
2577:
2575:
2572:
2570:
2567:
2564:
2563:
2560:
2557:
2555:
2551:
2548:
2545:
2544:
2541:
2538:
2534:
2531:
2529:
2526:
2525:
2524:
2521:
2517:
2514:
2512:
2509:
2507:
2504:
2503:
2502:
2499:
2496:
2495:
2493:
2489:
2486:
2482:
2476:
2473:
2471:
2468:
2466:
2463:
2462:
2460:
2456:
2452:
2445:
2440:
2438:
2433:
2431:
2426:
2425:
2422:
2408:
2402:
2397:
2393:
2387:
2382:
2378:
2372:
2367:
2363:
2357:
2352:
2348:
2342:
2337:
2333:
2327:
2322:
2318:
2309:
2304:
2302:
2297:
2295:
2290:
2289:
2286:
2282:
2276:
2272:
2271:
2266:
2262:
2258:
2255:
2251:
2248:
2246:
2242:
2238:
2236:
2233:
2231:
2228:
2227:
2223:
2216:
2212:
2208:
2204:
2200:
2196:
2191:
2187:
2183:
2179:
2175:
2171:
2167:
2162:
2158:
2154:
2149:
2144:
2139:
2134:
2130:
2126:
2122:
2118:
2114:
2109:
2105:
2101:
2096:
2091:
2087:
2083:
2079:
2074:
2070:
2066:
2061:
2056:
2052:
2048:
2044:
2040:
2036:
2031:
2027:
2023:
2018:
2013:
2009:
2005:
2001:
1997:
1993:
1988:
1984:
1980:
1975:
1970:
1965:
1960:
1956:
1952:
1948:
1944:
1940:
1935:
1931:
1927:
1923:
1919:
1915:
1911:
1908:(2): 331–42.
1907:
1903:
1898:
1894:
1890:
1885:
1880:
1876:
1872:
1869:(3): 667–75.
1868:
1864:
1860:
1855:
1851:
1847:
1843:
1839:
1835:
1831:
1828:(5): 309–12.
1827:
1823:
1818:
1814:
1810:
1805:
1800:
1796:
1792:
1788:
1784:
1779:
1775:
1771:
1767:
1763:
1760:(3): 379–83.
1759:
1755:
1749:
1745:
1741:
1736:
1731:
1727:
1723:
1719:
1715:
1710:
1706:
1702:
1698:
1694:
1690:
1686:
1682:
1678:
1674:
1670:
1665:
1661:
1657:
1653:
1649:
1646:(3): 415–22.
1645:
1641:
1636:
1632:
1628:
1624:
1620:
1616:
1612:
1609:(4): 213–30.
1608:
1604:
1599:
1595:
1591:
1587:
1583:
1579:
1575:
1571:
1567:
1562:
1558:
1554:
1550:
1546:
1542:
1538:
1533:
1529:
1525:
1520:
1515:
1511:
1507:
1504:(6): 683–93.
1503:
1499:
1495:
1490:
1486:
1482:
1477:
1472:
1468:
1464:
1460:
1455:
1454:
1449:
1440:
1434:
1432:
1428:
1423:
1419:
1413:
1410:
1405:
1401:
1395:
1392:
1388:
1384:
1379:
1377:
1375:
1371:
1367:
1363:
1357:
1355:
1353:
1349:
1342:
1336:
1333:
1330:
1327:
1324:
1321:
1320:
1317:
1314:
1311:
1308:
1305:
1302:
1301:
1298:
1295:
1292:
1289:
1286:
1283:
1282:
1279:
1275:
1272:
1269:
1266:
1263:
1260:
1259:
1256:
1252:
1249:
1246:
1243:
1240:
1237:
1236:
1232:
1230:
1227:
1225:
1222:
1219:
1215:
1212:
1209:
1205:
1202:
1201:
1197:
1188:
1184:
1182:
1178:
1177:MHC class III
1174:
1169:
1165:
1161:
1153:
1151:
1149:
1146:
1142:
1138:
1126:
1121:
1117:
1113:
1110:
1106:
1099:
1097:
1094:
1090:
1086:
1082:
1079:
1075:
1071:
1064:
1062:
1058:
1054:
1048:
1044:
1041:
1035:
1033:
1027:
1023:
1020:
1016:
1009:
1007:
1003:
997:
993:
990:
984:
982:
976:
972:
969:
967:RefSeq (mRNA)
965:
958:
957:
952:
948:
945:
939:
938:
933:
929:
926:
924:
920:
913:
912:
907:
903:
900:
894:
893:
889:
884:
879:
875:
871:
867:
863:
858:
855:
853:
849:
842:
841:
836:
832:
829:
823:
822:
817:
813:
810:
808:
804:
801:
798:
796:
793:
789:
786:
782:
778:
771:
767:
762:
756:
753:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
727:
725:
722:
721:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
691:
689:
686:
685:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
650:
648:
645:
644:
641:
640:Gene ontology
637:
633:
621:
616:
612:
605:
600:
597:
595:
591:
583:
578:
567:
563:
559:
555:
551:
547:
543:
539:
535:
531:
530:
527:
523:
518:
515:
505:
501:
497:
493:
489:
485:
481:
477:
473:
469:
468:
465:
461:
456:
453:
452:
449:
447:
443:
441:
440:
436:
435:
432:
430:
426:
422:
418:
414:
406:
401:
397:
393:
388:
378:
374:
367:
360:
354:
347:
339:
335:
331:
326:
322:
317:
313:
305:
300:
296:
292:
287:
277:
273:
266:
259:
253:
246:
242:
236:
232:
228:
223:
219:
214:
210:
206:
202:
198:
194:
190:
186:
182:
178:
174:
170:
162:
157:
150:
145:
140:
129:
127:
123:
119:
115:
111:
107:
103:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
3334:expanding it
3323:
3113:
3074:fibrinolysis
3072:
2950:
2916:Chymotrypsin
2836:Opsonization
2831:inflammation
2819:Cytotoxicity
2736:
2726:
2706:C1-inhibitor
2702:
2568:
2565:
2546:
2497:
2406:
2391:
2376:
2361:
2346:
2331:
2280:
2268:
2201:(1): 49–53.
2198:
2194:
2169:
2165:
2120:
2116:
2085:
2081:
2045:(1): 61–70.
2042:
2038:
2002:(1): 153–7.
1999:
1995:
1946:
1942:
1905:
1901:
1866:
1862:
1825:
1821:
1786:
1757:
1753:
1717:
1672:
1668:
1643:
1639:
1606:
1602:
1569:
1565:
1543:(1): 37–49.
1540:
1536:
1501:
1497:
1466:
1462:
1421:
1412:
1403:
1394:
1335:inflammation
1213:
1181:chromosome 6
1179:) region on
1157:
1144:
1136:
1135:
1061:NP_001389804
1053:NP_001136178
1050:
1029:
1002:NM_001142706
999:
978:
954:
935:
909:
886:
838:
819:
799:
794:
540:human kidney
536:right kidney
506:human kidney
444:
437:
164:External IDs
83:
18:BF (protein)
2979:Factor XIIa
2959:Factor VIIa
2943:Coagulation
2314:PDB gallery
1233:Conditions
740:proteolysis
474:gallbladder
403:35,081,494
390:35,075,350
302:31,952,084
289:31,945,650
142:Identifiers
3373:Categories
3261:Subtilisin
3203:Batroxobin
2984:Kallikrein
2974:Factor XIa
2964:Factor IXa
2931:Pancreatic
2926:Neutrophil
2696:Inhibitors
1389:, May 2017
1368:, May 2017
1343:References
1196:Complement
1164:complement
448:(ortholog)
185:HomoloGene
3326:hydrolase
3289:Cathepsin
3275:Sedolisin
3251:Prostasin
2969:Factor Xa
2829:Inducing
1253:, C3 NeF
1057:NP_032224
1032:NP_001701
1006:NM_008198
981:NM_001710
785:Orthologs
193:GeneCards
3190:Venombin
3175:Tryptase
3170:Granzyme
3124:Factor I
3119:Factor D
3114:Factor B
2954:Thrombin
2951:factors:
2921:Elastase
2821:(by MAC)
2812:Function
2740:Factor H
2720:Factor I
2574:Factor D
2569:Factor B
2458:Pathways
1930:32752642
1850:13698345
1660:11367526
1631:25061446
1623:10072631
1528:21394116
1385:–
1364:–
1168:factor D
1154:Function
1109:Wikidata
764:Sources:
568:duodenum
482:duodenum
478:appendix
3229:Pronase
3219:Acrosin
3165:Chymase
3079:Plasmin
2911:Trypsin
2275:PDBe-KB
2265:UniProt
2245:S01.196
2215:8181962
2186:8125298
2157:6957884
2125:Bibcode
2104:6546754
2069:6342610
2060:1154056
2026:6323161
1983:6308626
1951:Bibcode
1922:3643061
1893:3140783
1884:1149358
1842:2249879
1813:2006911
1804:1150163
1774:1545147
1744:1445220
1735:1133207
1705:4262433
1677:Bibcode
1594:6149579
1574:Bibcode
1557:3315100
1519:3178140
1485:2307833
1387:Ensembl
1366:Ensembl
1141:protein
923:UniProt
852:Ensembl
791:Species
770:QuickGO
556:jejunum
423:pattern
281:6p21.33
149:Aliases
3256:Reelin
3198:Ancrod
3155:Other
2889:3.4.21
2588:Middle
2270:P00751
2256:(MeSH)
2241:MEROPS
2213:
2184:
2155:
2148:346964
2145:
2102:
2067:
2057:
2024:
2017:557312
2014:
1981:
1974:384059
1971:
1928:
1920:
1891:
1881:
1848:
1840:
1811:
1801:
1772:
1742:
1732:
1703:
1697:889587
1695:
1669:Nature
1658:
1629:
1621:
1592:
1555:
1526:
1516:
1483:
1198:tests
1095:search
1093:PubMed
956:P04186
937:P00751
807:Entrez
594:BioGPS
181:105975
173:138470
3324:This
3265:Furin
3212:Other
3139:MASP2
3134:MASP1
3064:KLK15
3059:KLK14
3054:KLK13
3049:KLK12
3044:KLK11
3039:KLK10
2782:CD11c
2778:CD11b
2554:MASP2
2550:MASP1
2491:Early
1926:S2CID
1846:S2CID
1701:S2CID
1627:S2CID
1139:is a
840:14962
800:Mouse
795:Human
766:Amigo
564:colon
560:ileum
552:liver
446:Mouse
439:Human
386:Start
321:Mouse
285:Start
218:Human
3330:stub
3279:TPP1
3129:MASP
3034:KLK9
3029:KLK8
3024:KLK7
3019:KLK6
3014:KLK5
3009:KLK4
3004:KLK3
2999:KLK2
2994:KLK1
2786:CD18
2730:C4BP
2715:CD59
2703:CLA:
2649:Late
2609:iC3b
2407:2ok5
2392:1rtk
2377:1rs0
2362:1rrk
2347:1q0p
2332:1dle
2263:for
2239:The
2211:PMID
2182:PMID
2166:Gene
2153:PMID
2100:PMID
2065:PMID
2022:PMID
1979:PMID
1918:PMID
1902:Cell
1889:PMID
1838:PMID
1809:PMID
1770:PMID
1740:PMID
1693:PMID
1656:PMID
1619:PMID
1590:PMID
1553:PMID
1524:PMID
1481:PMID
1306:·/↓
1297:TCPD
1229:CH50
1148:gene
429:Bgee
377:Band
338:Chr.
276:Band
235:Chr.
189:1292
169:OMIM
126:3HRZ
122:2XWJ
118:2XWB
114:2WIN
110:2OK5
106:1RTK
102:1RS0
98:1RRK
94:1Q0P
90:1DLE
86:3HS0
67:RCSB
64:PDBe
3269:S1P
2989:PSA
2801:C5a
2796:C3a
2773:CR4
2768:CR3
2763:CR2
2758:CR1
2727:CL:
2661:C5b
2656:MAC
2626:C5b
2621:C5a
2605:C3b
2600:C3a
2559:MBL
2533:C4b
2528:C4a
2516:C1s
2511:C1r
2506:C1q
2261:PDB
2203:doi
2174:doi
2170:138
2143:PMC
2133:doi
2090:doi
2086:259
2055:PMC
2047:doi
2043:209
2012:PMC
2004:doi
1969:PMC
1959:doi
1910:doi
1879:PMC
1871:doi
1867:253
1830:doi
1799:PMC
1791:doi
1762:doi
1730:PMC
1722:doi
1685:doi
1673:268
1648:doi
1611:doi
1582:doi
1570:306
1545:doi
1514:PMC
1506:doi
1498:Eye
1471:doi
1467:144
1316:SLE
1278:C4D
1274:HAE
1251:PSG
1162:of
1145:CFB
821:629
399:End
298:End
201:OMA
197:CFB
177:MGI
156:CFB
57:PDB
33:CFB
3375::
2886:EC
2880::
2737:A:
2681:C9
2676:C8
2671:C7
2666:C6
2616:C5
2595:C3
2566:A:
2547:L:
2540:C2
2523:C4
2501:C1
2498:C:
2267::
2209:.
2199:39
2197:.
2180:.
2168:.
2151:.
2141:.
2131:.
2121:79
2119:.
2115:.
2098:.
2084:.
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2037:.
2020:.
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1967:.
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1947:80
1945:.
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1420:.
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1373:^
1351:^
1331:↑
1328:↑
1325:↑
1322:↑
1312:↓
1309:↓
1303:↓
1293:↓
1290:·
1287:·
1284:·
1276:,
1270:·
1267:↓
1264:·
1261:↓
1255:AA
1247:↓
1244:↓
1241:↓
1238:·
1224:C3
1220:)
1214:FB
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1204:C4
1150:.
768:/
405:bp
392:bp
304:bp
291:bp
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2607:/
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