301:
278:
175:
200:
1544:
growth factors, which prevents the closing of arteries by proliferating endothelial cells. When this gene is inhibited, vascular smooth muscle proliferates and can cause pulmonary hypertension, which, among other things, can lead to cor pulmonale, a condition that causes the right side of the heart to fail. The dysfunction of BMPR2 can also lead to an elevation in pulmonary arterial pressure due to an adverse response of the pulmonary circuit to injury.
307:
206:
6838:
1483:
serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. They bind to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs. In
2017:
Grünig E, Weissmann S, Ehlken N, Fijalkowska A, Fischer C, Fourme T, Galié N, Ghofrani A, Harrison RE, Huez S, Humbert M, Janssen B, Kober J, Koehler R, Machado RD, Mereles D, Naeije R, Olschewski H, Provencher S, Reichenberger F, Retailleau K, Rocchi G, Simonneau G, Torbicki A, Trembath R, Seeger W
1543:
BMPR2 functions to inhibit the proliferation of vascular smooth muscle tissue. It functions by promoting the survival of pulmonary arterial endothelial cells, therefore preventing arterial damage and adverse inflammatory responses. It also inhibits pulmonary arterial proliferation in response to
1523:
It appears that the hormones estrogen and follicle stimulating hormone (FSH) have roles in regulating expression of BMPR2 in granulosa cells. Experimental treatment in animal models with estradiol with or without FSH increased BMPR2 mRNA expression while treatment with FSH alone decreased BMPR2
1482:
Unlike the TGFβ type II receptor, which has a high affinity for TGF-β1, BMPR2 does not have a high affinity for BMP-2, BMP-7 and BMP-4, unless it is co-expressed with a type I BMP receptor. On ligand binding, a receptor complex is formed, consisting of two type II and two type I transmembrane
50:
1516:. However, BMPR2 can't bind BMP15 and GDF9 without the assistance of bone morphogenetic protein receptor 1B (BMPR1B) and transforming growth factor β receptor 1 (TGFβR1) respectively. There is evidence that the BMPR2 signaling pathway is disrupted in the case of
2020:"Stress Doppler echocardiography in relatives of patients with idiopathic and familial pulmonary arterial hypertension: results of a multicenter European analysis of pulmonary artery pressure response to exercise and hypoxia"
1507:
cells, and is a crucial receptor for bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF 9). These two protein signaling molecules and their BMPR2-mediated effects play an important role in
3073:
3358:
5220:
1495:
shifts towards the homodimeric form. The low affinity for ligands suggests that BMPR2 may differ from other type II TGF beta receptors in that the ligand may bind the type I receptor first.
1841:"Temporal regulation of BMP2, BMP6, BMP15, GDF9, BMPR1A, BMPR1B, BMPR2 and TGFBR1 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig"
3066:
1792:"Single-cell expression analysis of BMP15 and GDF9 in mature oocytes and BMPR2 in cumulus cells of women with polycystic ovary syndrome undergoing controlled ovarian hyperstimulation"
5213:
1751:"The cooperative effect of growth and differentiation factor-9 and bone morphogenetic protein (BMP)-15 on granulosa cell function is modulated primarily through BMP receptor II"
3059:
3266:
2689:
314:
213:
5206:
1554:
There have been studies which has correlated BMPR2 with exercise induced elevation of PA pressure by measuring tricuspid regurgitation velocity by echocardiography.
1487:
all of the receptors exist in homodimers before ligand binding. In the case of BMP receptors only a small fraction of the receptors exist in homomeric forms before
3814:
4653:
3117:
2656:
2117:
4762:
2788:
2417:
2138:
1467:
3500:
3387:
1156:
3775:
6868:
2982:
2554:
2548:
2543:
2533:
2528:
2523:
2518:
2513:
1137:
136:
4748:
4213:
3104:
3086:
2737:
4850:
4731:
3000:
6778:
4437:
3306:
1653:"Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors"
4501:
3476:
3038:
2907:
2682:
1630:
6858:
4757:
2783:
2722:
2370:
1612:
1551:
mutations in relatives of patients with idiopathic pulmonary hypertension, for these mutations are present in >70% of familial cases.
6863:
3291:
2837:
2832:
2827:
2822:
2220:
1360:
300:
4814:
4489:
2462:
2077:
4929:
3746:
3736:
3421:
2817:
1367:
277:
4428:
2926:
2675:
2110:
1427:
6697:
6123:
5767:
5463:
5318:
4697:
4369:
3731:
3722:
2602:
2325:
2160:
1599:
1578:
1537:
2970:
5085:
1595:
2083:
199:
174:
47:
6529:
6365:
6230:
6113:
6015:
5941:
5753:
5644:
5308:
4112:
3609:
3600:
3257:
3203:
2949:
2612:
2285:
2278:
2273:
2268:
2263:
6828:
1882:"Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases"
1574:
1491:
binding. Once a ligand has bound to a receptor, the amount of homomeric receptor oligomers increase, suggesting that the
6655:
6565:
6501:
6321:
6198:
6086:
5897:
5543:
5243:
5229:
3300:
2978:
2852:
2718:
2258:
2253:
2248:
2243:
2238:
2233:
116:
2103:
1435:
313:
212:
3051:
1524:
expression. However, in human granulosa-like tumor cell line (KGN), treatment with FSH increased BMPR2 expression.
6497:
6317:
6194:
5893:
5539:
5432:
5293:
4324:
4142:
3638:
2992:
2745:
2564:
2228:
1790:
de
Resende LO, Vireque AA, Santana LF, Moreno DA, de Sá Rosa e Silva AC, Ferriani RA, Scrideli CA, Reis RM (2012).
1484:
1463:
5070:
306:
205:
6641:
5534:
5422:
5186:
5173:
5160:
5147:
5134:
5121:
5108:
4314:
4309:
4304:
4294:
4289:
4284:
4274:
4069:
3844:
3440:
2347:
2130:
1517:
5080:
5034:
4977:
4537:
4528:
4479:
3245:
3090:
2805:
2776:
2771:
2710:
2445:
2390:
2374:
1201:
124:
4982:
4837:
4260:
2727:
2698:
1182:
2702:
1532:
At least 70 disease-causing mutations in this gene have been discovered. An inactivating mutation in the
5003:
4922:
3536:
5075:
4103:
3033:
2902:
1893:
1492:
1459:
188:
1702:"BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II"
103:
6878:
6788:
5039:
2759:
2754:
2497:
2182:
2089:
1992:
1447:
5982:
5593:
5496:
4611:
6888:
6883:
6873:
6738:
6613:
5376:
5235:
4972:
4714:
4668:
2749:
2572:
2361:
148:
6570:
6413:
6252:
5967:
2071:
1343:
1322:
1296:
1275:
1271:
6171:
6072:
5860:
5855:
5825:
5820:
5720:
6763:
5840:
5303:
3974:
3683:
2592:
2152:
2041:
1968:
1919:
1862:
1821:
1772:
1731:
1682:
96:
40:
6062:
5987:
5810:
5710:
5598:
5501:
5351:
107:, BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK, bone morphogenetic protein receptor type 2
6783:
6773:
5865:
5815:
5506:
5356:
5018:
5013:
4987:
4915:
4567:
3809:
3799:
3794:
3712:
3703:
3633:
3624:
3570:
3561:
3218:
2766:
2617:
2607:
2366:
2148:
2061:
2031:
1958:
1950:
1909:
1901:
1852:
1811:
1803:
1762:
1721:
1713:
1672:
1664:
1509:
393:
324:
268:
223:
6166:
5977:
5588:
5491:
5486:
1466:
begins with the binding of a BMP to the type II receptor. This causes the recruitment of a
144:
6594:
6524:
6519:
6437:
6360:
6355:
6225:
6220:
6043:
5936:
5931:
5691:
5578:
5573:
5458:
5065:
5049:
4962:
4393:
3464:
3459:
3454:
2597:
368:
2095:
1897:
6842:
5198:
5103:
5044:
2939:
2501:
2126:
1963:
1938:
1914:
1881:
1816:
1791:
2036:
2019:
1726:
1701:
1071:
1066:
1061:
1056:
1051:
1046:
1041:
1036:
1031:
1026:
1021:
1016:
1011:
1006:
1001:
996:
991:
986:
981:
976:
971:
966:
961:
956:
951:
946:
941:
936:
931:
926:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
680:
675:
659:
654:
649:
644:
639:
634:
629:
624:
619:
614:
609:
604:
599:
594:
589:
584:
6852:
6748:
5341:
5008:
4967:
3517:
3449:
2874:
2869:
2864:
2667:
1677:
1652:
571:
1749:
Edwards SJ, Reader KL, Lun S, Western A, Lawrence S, McNatty KP, Juengel JL (2008).
128:
6768:
6151:
6146:
5835:
5795:
5790:
5366:
4957:
4388:
3213:
2858:
1470:, which the type II receptor phosphorylates. The type I receptor phosphorylates an
1451:
386:
165:
152:
6758:
6456:
6156:
5800:
5181:
5116:
4952:
4594:
4226:
4166:
4049:
3969:
3693:
2627:
2587:
1635:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1617:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1455:
6837:
1905:
1717:
1027:
negative regulation of cell proliferation involved in heart valve morphogenesis
469:
6798:
6709:
6705:
6701:
6491:
6311:
6135:
6131:
6127:
5830:
5779:
5775:
5771:
5638:
5475:
5471:
5467:
5416:
5330:
5326:
5322:
5282:
4682:
3156:
2483:
2175:
2170:
2165:
2066:
1807:
285:
182:
132:
1651:
Gilboa L, Nohe A, Geissendörfer T, Sebald W, Henis YI, Knaus P (March 2000).
6691:
6687:
6678:
6588:
6584:
6555:
6487:
6483:
6431:
6427:
6403:
6307:
6303:
6270:
6266:
6108:
6067:
5850:
5748:
5715:
5685:
5681:
5662:
5634:
5630:
5427:
5412:
5408:
5288:
5278:
5274:
5155:
5129:
3643:
2320:
1513:
1504:
1101:
529:
407:
352:
339:
251:
238:
140:
6664:
6095:
2045:
1972:
1923:
1866:
1825:
1776:
1735:
1686:
2067:
GeneReviews/NCBI/NIH/UW entry on
Heritable Pulmonary Arterial Hypertension
1668:
1407:
1402:
6815:
3999:
3894:
3889:
3884:
1767:
1750:
1439:
1391:
1246:
1227:
1857:
1840:
777:
transmembrane receptor protein serine/threonine kinase signaling pathway
6753:
6743:
6683:
6580:
6479:
6423:
6299:
6262:
5677:
5626:
5404:
5270:
4658:
4636:
4631:
4621:
4616:
4418:
4413:
4408:
4403:
4398:
4383:
4378:
4029:
3994:
3233:
3228:
3223:
2582:
2577:
1839:
Paradis F, Novak S, Murdoch GK, Dyck MK, Dixon WT, Foxcroft GR (2009).
1213:
1168:
807:
positive regulation of pathway-restricted SMAD protein phosphorylation
73:
69:
6804:
6602:
6598:
6466:
6445:
6441:
6281:
6051:
6047:
5845:
5699:
5695:
5168:
4938:
4888:
4883:
4878:
4873:
4868:
4863:
4858:
4809:
4804:
4799:
4794:
4789:
4772:
4767:
4641:
4626:
4577:
4572:
4557:
4552:
4547:
4542:
4516:
4511:
4506:
4494:
4472:
4467:
4359:
4334:
4009:
3834:
3829:
3824:
3819:
3804:
3648:
3585:
3580:
3575:
3551:
3377:
3372:
3346:
3341:
3336:
3326:
3321:
3311:
3151:
3082:
3010:
3005:
2640:
2539:
2509:
2455:
2450:
2427:
2422:
2412:
2405:
2400:
1954:
1488:
1471:
1443:
1375:
1123:
5880:
5521:
6733:
6665:
6623:
6560:
6408:
6397:
6393:
6349:
6345:
6341:
6214:
6182:
6117:
6096:
6033:
6027:
5961:
5925:
5921:
5917:
5761:
5757:
5735:
5667:
5656:
5567:
5563:
5452:
5448:
5297:
5142:
4784:
4687:
4584:
4484:
4462:
4457:
4452:
4447:
4442:
4354:
4349:
4344:
4339:
4329:
4299:
4279:
4156:
4151:
4132:
4127:
4117:
4093:
4088:
4083:
4059:
4054:
4044:
4039:
4034:
4024:
4004:
3989:
3984:
3979:
3959:
3954:
3944:
3939:
3934:
3929:
3924:
3914:
3909:
3904:
3899:
3879:
3874:
3869:
3864:
3859:
3854:
3839:
3789:
3784:
3678:
3673:
3668:
3663:
3658:
3653:
3614:
3546:
3541:
3490:
3485:
3411:
3406:
3401:
3367:
3359:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
3161:
3146:
3141:
3136:
3131:
3126:
3017:
2889:
2635:
2395:
2340:
2335:
2330:
2209:
2202:
2197:
2192:
1086:
1082:
6549:
6545:
6541:
6537:
6533:
6513:
6509:
6505:
6389:
6385:
6381:
6377:
6373:
6369:
6337:
6333:
6329:
6325:
6246:
6242:
6238:
6234:
6210:
6206:
6202:
6023:
6019:
5997:
5957:
5953:
5949:
5945:
5913:
5909:
5905:
5901:
5875:
5730:
5652:
5648:
5608:
5559:
5555:
5551:
5547:
5516:
5444:
5440:
5436:
5386:
5312:
5252:
4677:
4604:
4599:
4589:
4562:
4319:
4269:
4250:
4245:
4240:
4235:
4190:
4185:
4180:
4175:
4122:
4078:
4019:
4014:
3964:
3949:
3919:
3849:
3765:
3760:
3755:
3688:
3590:
3531:
3526:
3430:
3396:
3281:
3276:
3271:
3240:
3208:
3196:
3191:
3186:
3176:
3171:
2954:
2944:
2922:
2315:
2310:
2305:
2300:
2295:
2290:
2187:
120:
5202:
4911:
4835:
4211:
3102:
3055:
2671:
2099:
847:
positive regulation of axon extension involved in axon guidance
585:
transmembrane receptor protein serine/threonine kinase activity
6624:
4646:
3181:
3166:
1450:. BMPs are involved in a host of cellular functions including
1993:"Rescuing the BMPR2 Pathway: How and Where Can We Intervene?"
872:
vascular endothelial growth factor receptor signaling pathway
1939:"Molecular pathogenesis of pulmonary arterial hypertension"
650:
transforming growth factor beta-activated receptor activity
4907:
2072:
OMIM entries on
Heritable Pulmonary Arterial Hypertension
1057:
transforming growth factor beta receptor signaling pathway
655:
transforming growth factor beta receptor activity, type II
1037:
positive regulation of transcription by RNA polymerase II
376:
6628:
5230:
917:
negative regulation of systemic arterial blood pressure
5998:
5876:
5731:
5609:
5517:
5387:
5257:
5253:
6826:
787:
positive regulation of endothelial cell proliferation
541:
6723:
6663:
6654:
6622:
6465:
6280:
6180:
6094:
6085:
5996:
5874:
5729:
5607:
5515:
5385:
5251:
5242:
5094:
5058:
5027:
4996:
4945:
4849:
4747:
4730:
4713:
4696:
4667:
4527:
4427:
4368:
4259:
4225:
4165:
4141:
4102:
4068:
3774:
3745:
3721:
3702:
3623:
3599:
3560:
3516:
3499:
3475:
3439:
3420:
3386:
3357:
3290:
3256:
3116:
3026:
2991:
2969:
2804:
2736:
2709:
2649:
2626:
2563:
2496:
2476:
2438:
2383:
2360:
2218:
2146:
2137:
1336:
1315:
1289:
1264:
6002:
5613:
5391:
1591:
1589:
1587:
1570:
1568:
1566:
927:retina vasculature development in camera-type eye
922:positive regulation of osteoblast differentiation
797:positive regulation of endothelial cell migration
323:
222:
6467:
6282:
972:negative regulation of chondrocyte proliferation
772:positive regulation of epithelial cell migration
6286:
1986:
1984:
1982:
907:negative regulation of DNA biosynthetic process
16:Protein-coding gene in the species Homo sapiens
1596:GRCm38: Ensembl release 89: ENSMUSG00000067336
5214:
4923:
3118:Non-specific serine/threonine protein kinases
3067:
2683:
2111:
8:
1503:BMPR2 is expressed on both human and animal
957:positive regulation of BMP signaling pathway
887:positive regulation of cartilage development
1646:
1644:
1575:GRCh38: Ensembl release 89: ENSG00000204217
1420:Bone morphogenetic protein receptor type II
817:regulation of cell population proliferation
6660:
6091:
5248:
5221:
5207:
5199:
4930:
4916:
4908:
4846:
4832:
4222:
4208:
3501:Goodpasture-antigen-binding protein kinase
3113:
3099:
3074:
3060:
3052:
2810:
2690:
2676:
2668:
2380:
2143:
2118:
2104:
2096:
1700:Kirsch T, Nickel J, Sebald W (July 2000).
1097:
977:lymphatic endothelial cell differentiation
967:positive regulation of bone mineralization
567:
364:
263:
160:
58:
4214:Serine/threonine-specific protein kinases
3388:(isocitrate dehydrogenase (NADP+)) kinase
3105:Serine/threonine-specific protein kinases
3087:Serine/threonine-specific protein kinases
2035:
1962:
1913:
1880:Šimčíková D, Heneberg P (December 2019).
1856:
1815:
1766:
1725:
1676:
1547:It is especially important to screen for
4749:Receptor protein serine/threonine kinase
2738:Receptor protein serine/threonine kinase
812:anterior/posterior pattern specification
595:protein serine/threonine kinase activity
6833:
4732:Low-density-lipoprotein receptor kinase
1562:
782:negative regulation of vasoconstriction
18:
3477:Fas-activated serine/threonine kinase
952:retina development in camera-type eye
711:integral component of plasma membrane
686:spanning component of plasma membrane
328:
289:
284:
227:
186:
181:
7:
4758:Bone morphogenetic protein receptors
1002:atrioventricular valve morphogenesis
987:pharyngeal arch artery morphogenesis
3292:Dephospho-(reductase kinase) kinase
1032:positive regulation of ossification
6731:Endogenous antagonists/inhibitors:
3747:G-protein coupled receptor kinases
1997:Pulmonary Hypertension Association
1333:
1312:
1286:
1261:
1237:
1218:
1192:
1173:
1147:
1128:
1007:activin receptor signaling pathway
997:outflow tract septum morphogenesis
832:transcription by RNA polymerase II
827:negative regulation of cell growth
767:endothelial cell apoptotic process
600:activin receptor activity, type II
546:
464:
402:
381:
14:
3737:Beta adrenergic receptor kinase-2
3422:(tyrosine 3-monooxygenase) kinase
2037:10.1161/CIRCULATIONAHA.108.800938
1012:cardiac muscle tissue development
932:cellular response to BMP stimulus
882:proteoglycan biosynthetic process
837:regulation of lung blood pressure
434:lateral nuclear group of thalamus
6869:Developmental genes and proteins
6836:
4429:Mitogen-activated protein kinase
1520:, possibly by hyperaldosterism.
1428:serine/threonine receptor kinase
1042:ventricular septum morphogenesis
312:
305:
299:
276:
211:
204:
198:
173:
4815:Anti-Müllerian hormone receptor
4698:(acetyl-CoA carboxylase) kinase
4370:(RNA-polymerase)-subunit kinase
3732:Beta adrenergic receptor kinase
3723:Beta adrenergic receptor kinase
2139:TGF beta superfamily of ligands
1937:Rabinovitch M (December 2012).
1538:pulmonary arterial hypertension
1512:development in preparation for
1474:, a transcriptional regulator.
1022:endocardial cushion development
942:venous blood vessel development
902:cellular response to starvation
792:endochondral bone morphogenesis
5507:ML-347 (LDN-193719, VU0469381)
5357:ML-347 (LDN-193719, VU0469381)
4438:Extracellular signal-regulated
3001:Platelet-derived growth factor
2971:Tumor necrosis factor receptor
2286:Growth differentiation factors
897:endothelial cell proliferation
676:integral component of membrane
530:More reference expression data
1:
4502:P38 mitogen-activated protein
3601:cGMP-dependent protein kinase
3562:cAMP-dependent protein kinase
3258:Pyruvate dehydrogenase kinase
3204:Ataxia telangiectasia mutated
1062:pattern specification process
992:tricuspid valve morphogenesis
892:maternal placenta development
297:
196:
3301:AMP-activated protein kinase
3039:Insulin-like growth factor 2
2908:Insulin-like growth factor 1
1052:semi-lunar valve development
6859:Genes on human chromosome 2
5846:RepSox (E-616452, SJN-2511)
4216:(EC 2.7.11.21-EC 2.7.11.30)
2723:Ciliary neurotrophic factor
2229:Bone morphogenetic proteins
2062:BMPR2 gene variant database
1436:bone morphogenetic proteins
1072:pulmonary valve development
1047:atrial septum morphogenesis
1017:outflow tract morphogenesis
6905:
6864:Bone morphogenetic protein
4143:Elongation factor 2 kinase
3107:(EC 2.7.11.1-EC 2.7.11.20)
2784:Bone morphogenetic protein
2088:gene details page in the
1906:10.1038/s41598-019-54976-4
982:mitral valve morphogenesis
508:retinal pigment epithelium
5836:Galunisertib (LY-2157299)
5086:Michaelis–Menten kinetics
4845:
4831:
4538:MAP kinase kinase kinases
4221:
4207:
4070:Myosin light-chain kinase
3776:Ca2+/calmodulin-dependent
3441:Myosin-heavy-chain kinase
3112:
3098:
2935:
2918:
2898:
2885:
2848:
2813:
1808:10.1007/s10815-012-9825-8
1631:"Mouse PubMed Reference:"
1613:"Human PubMed Reference:"
1518:polycystic ovary syndrome
1406:
1401:
1397:
1390:
1374:
1361:Chr 2: 202.38 – 202.57 Mb
1355:
1340:
1319:
1308:
1293:
1268:
1257:
1244:
1240:
1225:
1221:
1212:
1199:
1195:
1180:
1176:
1167:
1154:
1150:
1135:
1131:
1122:
1107:
1100:
1096:
1080:
822:lung alveolus development
570:
566:
554:
549:
540:
527:
476:
467:
414:
405:
375:
367:
363:
346:
333:
296:
275:
266:
262:
245:
232:
195:
172:
163:
159:
114:
111:
101:
94:
89:
66:
61:
44:
39:
34:
30:
26:
21:
6784:Thrombospondin 1 (THBS1)
6566:Osteogenin (BMP3, BMP3A)
4978:Diffusion-limited enzyme
4838:Dual-specificity kinases
2890:Hepatocyte growth factor
2818:Fibroblast growth factor
2806:Receptor tyrosine kinase
2711:Type I cytokine receptor
2446:Activin type 2 receptors
2391:Activin type 1 receptors
1796:J. Assist. Reprod. Genet
1718:10.1093/emboj/19.13.3314
1536:gene has been linked to
1446:, which are involved in
1067:aortic valve development
426:tendon of biceps brachii
4261:Cyclin-dependent kinase
2927:Epidermal growth factor
2703:growth factor receptors
912:chondrocyte development
857:blood vessel remodeling
842:protein phosphorylation
610:protein kinase activity
5983:Dorsomorphin (BML-275)
5594:Dorsomorphin (BML-275)
5497:Dorsomorphin (BML-275)
2348:Anti-müllerian hormone
2131:TGFβ signaling pathway
1991:Rabinovitch, Marlene.
1368:Chr 1: 59.8 – 59.92 Mb
731:apical plasma membrane
5071:Eadie–Hofstee diagram
5004:Allosteric regulation
1669:10.1091/mbc.11.3.1023
1528:Clinical significance
862:BMP signaling pathway
726:basal plasma membrane
645:BMP receptor activity
625:growth factor binding
5233:receptor superfamily
5081:Lineweaver–Burk plot
4104:Phosphorylase kinase
2979:Nerve growth factors
2853:Nerve growth factors
2719:Nerve growth factors
2082:genome location and
1768:10.1210/en.2007-1328
1460:cell differentiation
746:postsynaptic density
640:transferase activity
291:Chromosome 1 (mouse)
189:Chromosome 2 (human)
62:List of PDB id codes
35:Available structures
6801:(against myostatin)
2183:Activin and inhibin
2090:UCSC Genome Browser
1898:2019NatSR...918577S
1858:10.1530/REP-08-0538
1468:BMP type I receptor
1462:. Signaling in the
1448:paracrine signaling
877:signal transduction
736:extracellular space
6807:(against endoglin)
6164:Kinase inhibitors:
6060:Kinase inhibitors:
5975:Kinase inhibitors:
5808:Kinase inhibitors:
5708:Kinase inhibitors:
5586:Kinase inhibitors:
5484:Kinase inhibitors:
5349:Kinase inhibitors:
5040:Enzyme superfamily
4973:Enzyme promiscuity
4715:Tropomyosin kinase
4669:Tau-protein kinase
2362:TGF beta receptors
1886:Scientific Reports
1499:Oocyte Development
1485:TGF beta signaling
1202:ENSMUSG00000067336
867:mesoderm formation
852:artery development
760:Biological process
696:neuronal cell body
669:Cellular component
635:nucleotide binding
578:Molecular function
516:epithelium of lens
454:tail of epididymis
422:lower lobe of lung
6824:
6823:
6719:
6718:
6650:
6649:
6081:
6080:
5374:Other inhibitors:
5196:
5195:
4905:
4904:
4901:
4900:
4897:
4896:
4827:
4826:
4823:
4822:
4203:
4202:
4199:
4198:
3684:Protein kinase N1
3639:Protein kinase Cζ
3049:
3048:
2965:
2964:
2665:
2664:
2565:Ligand inhibitors
2492:
2491:
2356:
2355:
1438:, members of the
1417:
1416:
1413:
1412:
1386:
1385:
1351:
1350:
1330:
1329:
1304:
1303:
1283:
1282:
1253:
1252:
1234:
1233:
1208:
1207:
1189:
1188:
1163:
1162:
1144:
1143:
1092:
1091:
947:brain development
802:lymphangiogenesis
630:metal ion binding
562:
561:
558:
557:
536:
535:
523:
522:
461:
460:
359:
358:
258:
257:
153:BMPR2 - orthologs
85:
84:
81:
80:
45:Ortholog search:
6896:
6841:
6840:
6832:
6667:
6661:
6630:
6626:
6611:Decoy receptors:
6556:Myostatin (GDF8)
6469:
6454:Decoy receptors:
6404:Myostatin (GDF8)
6288:
6284:
6184:
6098:
6092:
6004:
6000:
5882:
5878:
5737:
5733:
5663:Myostatin (GDF8)
5615:
5611:
5523:
5519:
5393:
5389:
5364:Decoy receptors:
5259:
5255:
5249:
5232:
5223:
5216:
5209:
5200:
5076:Hanes–Woolf plot
5019:Enzyme activator
5014:Enzyme inhibitor
4988:Enzyme catalysis
4932:
4925:
4918:
4909:
4847:
4833:
4480:C-Jun N-terminal
4223:
4209:
3713:Rhodopsin kinase
3704:Rhodopsin kinase
3634:Protein kinase C
3625:Protein kinase C
3610:Protein kinase G
3571:Protein kinase A
3182:Protein kinase B
3114:
3100:
3076:
3069:
3062:
3053:
3018:Stem cell factor
2983:Low affinity/p75
2811:
2692:
2685:
2678:
2669:
2381:
2144:
2120:
2113:
2106:
2097:
2050:
2049:
2039:
2014:
2008:
2007:
2005:
2003:
1988:
1977:
1976:
1966:
1955:10.1172/JCI60658
1934:
1928:
1927:
1917:
1877:
1871:
1870:
1860:
1836:
1830:
1829:
1819:
1787:
1781:
1780:
1770:
1746:
1740:
1739:
1729:
1697:
1691:
1690:
1680:
1648:
1639:
1638:
1627:
1621:
1620:
1609:
1603:
1593:
1582:
1572:
1399:
1398:
1370:
1363:
1346:
1334:
1325:
1313:
1309:RefSeq (protein)
1299:
1287:
1278:
1262:
1238:
1219:
1193:
1174:
1148:
1129:
1098:
962:limb development
751:receptor complex
568:
547:
532:
500:substantia nigra
472:
470:Top expressed in
465:
410:
408:Top expressed in
403:
382:
365:
355:
342:
331:
316:
309:
303:
292:
280:
264:
254:
241:
230:
215:
208:
202:
191:
177:
161:
155:
106:
99:
76:
59:
53:
32:
31:
19:
6904:
6903:
6899:
6898:
6897:
6895:
6894:
6893:
6849:
6848:
6847:
6835:
6827:
6825:
6820:
6739:Cerberus (CER1)
6715:
6646:
6618:
6525:Eptotermin alfa
6520:Dibotermin alfa
6461:
6361:Eptotermin alfa
6356:Dibotermin alfa
6276:
6226:Eptotermin alfa
6221:Dibotermin alfa
6176:
6077:
5992:
5937:Eptotermin alfa
5932:Dibotermin alfa
5870:
5725:
5603:
5579:Eptotermin alfa
5574:Dibotermin alfa
5511:
5459:Eptotermin alfa
5381:
5238:
5227:
5197:
5192:
5104:Oxidoreductases
5090:
5066:Enzyme kinetics
5054:
5050:List of enzymes
5023:
4992:
4963:Catalytic triad
4941:
4936:
4906:
4893:
4841:
4819:
4743:
4726:
4709:
4692:
4663:
4523:
4423:
4394:P70-S6 Kinase 1
4364:
4255:
4217:
4195:
4161:
4137:
4098:
4064:
3770:
3741:
3717:
3698:
3619:
3595:
3556:
3512:
3495:
3471:
3465:Aurora C kinase
3460:Aurora B kinase
3455:Aurora A kinase
3435:
3416:
3382:
3353:
3286:
3252:
3108:
3094:
3080:
3050:
3045:
3027:Other/ungrouped
3022:
2987:
2961:
2931:
2914:
2894:
2881:
2844:
2800:
2732:
2705:
2696:
2666:
2661:
2645:
2622:
2559:
2488:
2472:
2434:
2364:
2352:
2214:
2161:TGF beta family
2133:
2124:
2058:
2053:
2030:(13): 1747–57.
2016:
2015:
2011:
2001:
1999:
1990:
1989:
1980:
1949:(12): 4306–13.
1943:J. Clin. Invest
1936:
1935:
1931:
1879:
1878:
1874:
1838:
1837:
1833:
1802:(10): 1057–65.
1789:
1788:
1784:
1748:
1747:
1743:
1712:(13): 3314–24.
1699:
1698:
1694:
1657:Mol. Biol. Cell
1650:
1649:
1642:
1629:
1628:
1624:
1611:
1610:
1606:
1594:
1585:
1573:
1564:
1560:
1530:
1501:
1480:
1442:superfamily of
1434:gene. It binds
1430:encoded by the
1408:View/Edit Mouse
1403:View/Edit Human
1366:
1359:
1356:Location (UCSC)
1342:
1321:
1295:
1274:
1270:
1183:ENSG00000204217
1076:
937:phosphorylation
755:
716:plasma membrane
664:
620:kinase activity
615:protein binding
528:
519:
514:
510:
506:
502:
498:
496:right lung lobe
494:
490:
486:
482:
468:
457:
452:
448:
444:
440:
438:parietal pleura
436:
432:
428:
424:
420:
418:visceral pleura
406:
350:
337:
329:
319:
318:
317:
310:
290:
267:Gene location (
249:
236:
228:
218:
217:
216:
209:
187:
164:Gene location (
115:
102:
95:
68:
46:
17:
12:
11:
5:
6902:
6900:
6892:
6891:
6886:
6881:
6876:
6871:
6866:
6861:
6851:
6850:
6846:
6845:
6822:
6821:
6819:
6818:
6809:
6808:
6802:
6792:
6791:
6786:
6781:
6776:
6771:
6766:
6761:
6756:
6751:
6746:
6741:
6736:
6727:
6725:
6721:
6720:
6717:
6716:
6714:
6713:
6695:
6681:
6672:
6670:
6658:
6652:
6651:
6648:
6647:
6645:
6644:
6635:
6633:
6620:
6619:
6617:
6616:
6607:
6606:
6592:
6574:
6573:
6568:
6563:
6558:
6553:
6527:
6522:
6517:
6495:
6473:
6471:
6463:
6462:
6460:
6459:
6450:
6449:
6435:
6417:
6416:
6411:
6406:
6401:
6363:
6358:
6353:
6315:
6293:
6291:
6278:
6277:
6275:
6274:
6256:
6255:
6250:
6228:
6223:
6218:
6188:
6186:
6178:
6177:
6175:
6174:
6169:
6160:
6159:
6154:
6149:
6140:
6139:
6121:
6111:
6102:
6100:
6089:
6083:
6082:
6079:
6078:
6076:
6075:
6070:
6065:
6056:
6055:
6037:
6036:
6031:
6009:
6007:
5994:
5993:
5991:
5990:
5985:
5980:
5971:
5970:
5965:
5939:
5934:
5929:
5887:
5885:
5872:
5871:
5869:
5868:
5863:
5858:
5853:
5848:
5843:
5838:
5833:
5828:
5823:
5818:
5813:
5804:
5803:
5798:
5793:
5784:
5783:
5765:
5751:
5742:
5740:
5727:
5726:
5724:
5723:
5718:
5713:
5704:
5703:
5689:
5671:
5670:
5665:
5660:
5642:
5620:
5618:
5605:
5604:
5602:
5601:
5596:
5591:
5582:
5581:
5576:
5571:
5537:
5528:
5526:
5513:
5512:
5510:
5509:
5504:
5499:
5494:
5489:
5480:
5479:
5461:
5456:
5430:
5425:
5420:
5398:
5396:
5383:
5382:
5380:
5379:
5370:
5369:
5360:
5359:
5354:
5345:
5344:
5335:
5334:
5316:
5306:
5301:
5291:
5286:
5264:
5262:
5246:
5240:
5239:
5228:
5226:
5225:
5218:
5211:
5203:
5194:
5193:
5191:
5190:
5177:
5164:
5151:
5138:
5125:
5112:
5098:
5096:
5092:
5091:
5089:
5088:
5083:
5078:
5073:
5068:
5062:
5060:
5056:
5055:
5053:
5052:
5047:
5042:
5037:
5031:
5029:
5028:Classification
5025:
5024:
5022:
5021:
5016:
5011:
5006:
5000:
4998:
4994:
4993:
4991:
4990:
4985:
4980:
4975:
4970:
4965:
4960:
4955:
4949:
4947:
4943:
4942:
4937:
4935:
4934:
4927:
4920:
4912:
4903:
4902:
4899:
4898:
4895:
4894:
4892:
4891:
4886:
4881:
4876:
4871:
4866:
4861:
4855:
4853:
4843:
4842:
4836:
4829:
4828:
4825:
4824:
4821:
4820:
4818:
4817:
4812:
4807:
4802:
4797:
4792:
4787:
4782:
4781:
4780:
4775:
4770:
4765:
4754:
4752:
4751:(EC 2.7.11.30)
4745:
4744:
4742:
4741:
4737:
4735:
4734:(EC 2.7.11.29)
4728:
4727:
4725:
4724:
4720:
4718:
4717:(EC 2.7.11.28)
4711:
4710:
4708:
4707:
4703:
4701:
4700:(EC 2.7.11.27)
4694:
4693:
4691:
4690:
4685:
4680:
4674:
4672:
4671:(EC 2.7.11.26)
4665:
4664:
4662:
4661:
4656:
4651:
4650:
4649:
4644:
4639:
4634:
4629:
4624:
4619:
4609:
4608:
4607:
4602:
4597:
4592:
4582:
4581:
4580:
4575:
4570:
4565:
4560:
4555:
4550:
4545:
4534:
4532:
4531:(EC 2.7.11.25)
4525:
4524:
4522:
4521:
4520:
4519:
4514:
4509:
4499:
4498:
4497:
4492:
4487:
4477:
4476:
4475:
4470:
4465:
4460:
4455:
4450:
4445:
4434:
4432:
4431:(EC 2.7.11.24)
4425:
4424:
4422:
4421:
4416:
4411:
4406:
4401:
4396:
4391:
4386:
4381:
4375:
4373:
4372:(EC 2.7.11.23)
4366:
4365:
4363:
4362:
4357:
4352:
4347:
4342:
4337:
4332:
4327:
4322:
4317:
4312:
4307:
4302:
4297:
4292:
4287:
4282:
4277:
4272:
4266:
4264:
4263:(EC 2.7.11.22)
4257:
4256:
4254:
4253:
4248:
4243:
4238:
4232:
4230:
4229:(EC 2.7.11.21)
4219:
4218:
4212:
4205:
4204:
4201:
4200:
4197:
4196:
4194:
4193:
4188:
4183:
4178:
4172:
4170:
4169:(EC 2.7.11.21)
4163:
4162:
4160:
4159:
4154:
4148:
4146:
4145:(EC 2.7.11.20)
4139:
4138:
4136:
4135:
4130:
4125:
4120:
4115:
4109:
4107:
4106:(EC 2.7.11.19)
4100:
4099:
4097:
4096:
4091:
4086:
4081:
4075:
4073:
4072:(EC 2.7.11.18)
4066:
4065:
4063:
4062:
4057:
4052:
4047:
4042:
4037:
4032:
4027:
4022:
4017:
4012:
4007:
4002:
3997:
3992:
3987:
3982:
3977:
3972:
3967:
3962:
3957:
3952:
3947:
3942:
3937:
3932:
3927:
3922:
3917:
3912:
3907:
3902:
3897:
3892:
3887:
3882:
3877:
3872:
3867:
3862:
3857:
3852:
3847:
3842:
3837:
3832:
3827:
3822:
3817:
3812:
3807:
3802:
3797:
3792:
3787:
3781:
3779:
3778:(EC 2.7.11.17)
3772:
3771:
3769:
3768:
3763:
3758:
3752:
3750:
3749:(EC 2.7.11.16)
3743:
3742:
3740:
3739:
3734:
3728:
3726:
3725:(EC 2.7.11.15)
3719:
3718:
3716:
3715:
3709:
3707:
3706:(EC 2.7.11.14)
3700:
3699:
3697:
3696:
3691:
3686:
3681:
3676:
3671:
3666:
3661:
3656:
3651:
3646:
3641:
3636:
3630:
3628:
3627:(EC 2.7.11.13)
3621:
3620:
3618:
3617:
3612:
3606:
3604:
3603:(EC 2.7.11.12)
3597:
3596:
3594:
3593:
3588:
3583:
3578:
3573:
3567:
3565:
3564:(EC 2.7.11.11)
3558:
3557:
3555:
3554:
3549:
3544:
3539:
3534:
3529:
3523:
3521:
3520:(EC 2.7.11.10)
3514:
3513:
3511:
3510:
3506:
3504:
3497:
3496:
3494:
3493:
3488:
3482:
3480:
3473:
3472:
3470:
3469:
3468:
3467:
3462:
3457:
3446:
3444:
3437:
3436:
3434:
3433:
3427:
3425:
3418:
3417:
3415:
3414:
3409:
3404:
3399:
3393:
3391:
3384:
3383:
3381:
3380:
3375:
3370:
3364:
3362:
3355:
3354:
3352:
3351:
3350:
3349:
3344:
3339:
3331:
3330:
3329:
3324:
3316:
3315:
3314:
3309:
3297:
3295:
3288:
3287:
3285:
3284:
3279:
3274:
3269:
3263:
3261:
3254:
3253:
3251:
3250:
3249:
3248:
3238:
3237:
3236:
3231:
3226:
3221:
3211:
3206:
3201:
3200:
3199:
3194:
3189:
3179:
3174:
3169:
3164:
3159:
3154:
3149:
3144:
3139:
3134:
3129:
3123:
3121:
3110:
3109:
3103:
3096:
3095:
3081:
3079:
3078:
3071:
3064:
3056:
3047:
3046:
3044:
3043:
3042:
3041:
3030:
3028:
3024:
3023:
3021:
3020:
3015:
3014:
3013:
3008:
2997:
2995:
2993:Ig superfamily
2989:
2988:
2986:
2985:
2975:
2973:
2967:
2966:
2963:
2962:
2960:
2959:
2958:
2957:
2952:
2947:
2936:
2933:
2932:
2930:
2929:
2919:
2916:
2915:
2913:
2912:
2911:
2910:
2899:
2896:
2895:
2893:
2892:
2886:
2883:
2882:
2880:
2879:
2878:
2877:
2872:
2867:
2857:high affinity
2849:
2846:
2845:
2843:
2842:
2841:
2840:
2835:
2830:
2825:
2814:
2808:
2802:
2801:
2799:
2798:
2797:
2796:
2791:
2781:
2780:
2779:
2774:
2764:
2763:
2762:
2757:
2742:
2740:
2734:
2733:
2731:
2730:
2728:Erythropoietin
2725:
2715:
2713:
2707:
2706:
2697:
2695:
2694:
2687:
2680:
2672:
2663:
2662:
2660:
2659:
2653:
2651:
2647:
2646:
2644:
2643:
2638:
2632:
2630:
2624:
2623:
2621:
2620:
2615:
2610:
2605:
2600:
2595:
2590:
2585:
2580:
2575:
2569:
2567:
2561:
2560:
2558:
2557:
2552:
2546:
2537:
2531:
2526:
2521:
2516:
2506:
2504:
2494:
2493:
2490:
2489:
2487:
2486:
2480:
2478:
2474:
2473:
2471:
2470:
2465:
2460:
2459:
2458:
2453:
2442:
2440:
2436:
2435:
2433:
2432:
2431:
2430:
2425:
2415:
2410:
2409:
2408:
2403:
2398:
2387:
2385:
2378:
2358:
2357:
2354:
2353:
2351:
2350:
2345:
2344:
2343:
2338:
2333:
2328:
2323:
2321:Myostatin/GDF8
2318:
2313:
2308:
2303:
2298:
2293:
2283:
2282:
2281:
2276:
2271:
2266:
2261:
2256:
2251:
2246:
2241:
2236:
2225:
2223:
2216:
2215:
2213:
2212:
2207:
2206:
2205:
2200:
2195:
2190:
2180:
2179:
2178:
2173:
2168:
2157:
2155:
2141:
2135:
2134:
2127:Cell signaling
2125:
2123:
2122:
2115:
2108:
2100:
2094:
2093:
2074:
2069:
2064:
2057:
2056:External links
2054:
2052:
2051:
2009:
1978:
1929:
1872:
1831:
1782:
1761:(3): 1026–30.
1741:
1692:
1663:(3): 1023–35.
1640:
1622:
1604:
1583:
1561:
1559:
1556:
1529:
1526:
1500:
1497:
1479:
1476:
1415:
1414:
1411:
1410:
1405:
1395:
1394:
1388:
1387:
1384:
1383:
1381:
1379:
1372:
1371:
1364:
1357:
1353:
1352:
1349:
1348:
1338:
1337:
1331:
1328:
1327:
1317:
1316:
1310:
1306:
1305:
1302:
1301:
1291:
1290:
1284:
1281:
1280:
1266:
1265:
1259:
1255:
1254:
1251:
1250:
1242:
1241:
1235:
1232:
1231:
1223:
1222:
1216:
1210:
1209:
1206:
1205:
1197:
1196:
1190:
1187:
1186:
1178:
1177:
1171:
1165:
1164:
1161:
1160:
1152:
1151:
1145:
1142:
1141:
1133:
1132:
1126:
1120:
1119:
1114:
1109:
1105:
1104:
1094:
1093:
1090:
1089:
1078:
1077:
1075:
1074:
1069:
1064:
1059:
1054:
1049:
1044:
1039:
1034:
1029:
1024:
1019:
1014:
1009:
1004:
999:
994:
989:
984:
979:
974:
969:
964:
959:
954:
949:
944:
939:
934:
929:
924:
919:
914:
909:
904:
899:
894:
889:
884:
879:
874:
869:
864:
859:
854:
849:
844:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
763:
761:
757:
756:
754:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
688:
683:
678:
672:
670:
666:
665:
663:
662:
657:
652:
647:
642:
637:
632:
627:
622:
617:
612:
607:
602:
597:
592:
587:
581:
579:
575:
574:
564:
563:
560:
559:
556:
555:
552:
551:
544:
538:
537:
534:
533:
525:
524:
521:
520:
518:
517:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
474:
473:
462:
459:
458:
456:
455:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
412:
411:
399:
398:
390:
379:
373:
372:
369:RNA expression
361:
360:
357:
356:
348:
344:
343:
335:
332:
327:
321:
320:
311:
304:
298:
294:
293:
288:
282:
281:
273:
272:
260:
259:
256:
255:
247:
243:
242:
234:
231:
226:
220:
219:
210:
203:
197:
193:
192:
185:
179:
178:
170:
169:
157:
156:
113:
109:
108:
100:
92:
91:
87:
86:
83:
82:
79:
78:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
6901:
6890:
6887:
6885:
6882:
6880:
6877:
6875:
6872:
6870:
6867:
6865:
6862:
6860:
6857:
6856:
6854:
6844:
6839:
6834:
6830:
6817:
6814:
6811:
6810:
6806:
6803:
6800:
6797:
6794:
6793:
6790:
6789:Tomoregulin 1
6787:
6785:
6782:
6780:
6777:
6775:
6772:
6770:
6767:
6765:
6764:Gremlin (Drm)
6762:
6760:
6757:
6755:
6752:
6750:
6747:
6745:
6742:
6740:
6737:
6735:
6732:
6729:
6728:
6726:
6722:
6711:
6707:
6703:
6699:
6696:
6693:
6689:
6685:
6682:
6680:
6677:
6674:
6673:
6671:
6669:
6662:
6659:
6657:
6653:
6643:
6640:
6637:
6636:
6634:
6632:
6621:
6615:
6612:
6609:
6608:
6604:
6600:
6596:
6593:
6590:
6586:
6582:
6579:
6576:
6575:
6572:
6569:
6567:
6564:
6562:
6559:
6557:
6554:
6551:
6547:
6543:
6539:
6535:
6531:
6528:
6526:
6523:
6521:
6518:
6515:
6511:
6507:
6503:
6499:
6496:
6493:
6489:
6485:
6481:
6478:
6475:
6474:
6472:
6470:
6464:
6458:
6455:
6452:
6451:
6447:
6443:
6439:
6436:
6433:
6429:
6425:
6422:
6419:
6418:
6415:
6412:
6410:
6407:
6405:
6402:
6399:
6395:
6391:
6387:
6383:
6379:
6375:
6371:
6367:
6364:
6362:
6359:
6357:
6354:
6351:
6347:
6343:
6339:
6335:
6331:
6327:
6323:
6319:
6316:
6313:
6309:
6305:
6301:
6298:
6295:
6294:
6292:
6290:
6279:
6272:
6268:
6264:
6261:
6258:
6257:
6254:
6251:
6248:
6244:
6240:
6236:
6232:
6229:
6227:
6224:
6222:
6219:
6216:
6212:
6208:
6204:
6200:
6196:
6193:
6190:
6189:
6187:
6185:
6179:
6173:
6170:
6168:
6165:
6162:
6161:
6158:
6155:
6153:
6150:
6148:
6145:
6142:
6141:
6137:
6133:
6129:
6125:
6122:
6119:
6115:
6112:
6110:
6107:
6104:
6103:
6101:
6099:
6093:
6090:
6088:
6084:
6074:
6071:
6069:
6066:
6064:
6061:
6058:
6057:
6053:
6049:
6045:
6042:
6039:
6038:
6035:
6032:
6029:
6025:
6021:
6017:
6014:
6011:
6010:
6008:
6006:
5995:
5989:
5986:
5984:
5981:
5979:
5976:
5973:
5972:
5969:
5966:
5963:
5959:
5955:
5951:
5947:
5943:
5940:
5938:
5935:
5933:
5930:
5927:
5923:
5919:
5915:
5911:
5907:
5903:
5899:
5895:
5892:
5889:
5888:
5886:
5884:
5873:
5867:
5864:
5862:
5859:
5857:
5854:
5852:
5849:
5847:
5844:
5842:
5839:
5837:
5834:
5832:
5829:
5827:
5824:
5822:
5819:
5817:
5814:
5812:
5809:
5806:
5805:
5802:
5799:
5797:
5794:
5792:
5789:
5786:
5785:
5781:
5777:
5773:
5769:
5766:
5763:
5759:
5755:
5752:
5750:
5747:
5744:
5743:
5741:
5739:
5728:
5722:
5719:
5717:
5714:
5712:
5709:
5706:
5705:
5701:
5697:
5693:
5690:
5687:
5683:
5679:
5676:
5673:
5672:
5669:
5666:
5664:
5661:
5658:
5654:
5650:
5646:
5643:
5640:
5636:
5632:
5628:
5625:
5622:
5621:
5619:
5617:
5606:
5600:
5597:
5595:
5592:
5590:
5587:
5584:
5583:
5580:
5577:
5575:
5572:
5569:
5565:
5561:
5557:
5553:
5549:
5545:
5541:
5538:
5536:
5533:
5530:
5529:
5527:
5525:
5514:
5508:
5505:
5503:
5500:
5498:
5495:
5493:
5490:
5488:
5485:
5482:
5481:
5477:
5473:
5469:
5465:
5462:
5460:
5457:
5454:
5450:
5446:
5442:
5438:
5434:
5431:
5429:
5426:
5424:
5421:
5418:
5414:
5410:
5406:
5403:
5400:
5399:
5397:
5395:
5384:
5378:
5375:
5372:
5371:
5368:
5365:
5362:
5361:
5358:
5355:
5353:
5350:
5347:
5346:
5343:
5342:Ascrinvacumab
5340:
5337:
5336:
5332:
5328:
5324:
5320:
5317:
5314:
5310:
5307:
5305:
5302:
5299:
5295:
5292:
5290:
5287:
5284:
5280:
5276:
5272:
5269:
5266:
5265:
5263:
5261:
5250:
5247:
5245:
5241:
5237:
5234:
5224:
5219:
5217:
5212:
5210:
5205:
5204:
5201:
5188:
5184:
5183:
5178:
5175:
5171:
5170:
5165:
5162:
5158:
5157:
5152:
5149:
5145:
5144:
5139:
5136:
5132:
5131:
5126:
5123:
5119:
5118:
5113:
5110:
5106:
5105:
5100:
5099:
5097:
5093:
5087:
5084:
5082:
5079:
5077:
5074:
5072:
5069:
5067:
5064:
5063:
5061:
5057:
5051:
5048:
5046:
5045:Enzyme family
5043:
5041:
5038:
5036:
5033:
5032:
5030:
5026:
5020:
5017:
5015:
5012:
5010:
5009:Cooperativity
5007:
5005:
5002:
5001:
4999:
4995:
4989:
4986:
4984:
4981:
4979:
4976:
4974:
4971:
4969:
4968:Oxyanion hole
4966:
4964:
4961:
4959:
4956:
4954:
4951:
4950:
4948:
4944:
4940:
4933:
4928:
4926:
4921:
4919:
4914:
4913:
4910:
4890:
4887:
4885:
4882:
4880:
4877:
4875:
4872:
4870:
4867:
4865:
4862:
4860:
4857:
4856:
4854:
4852:
4848:
4844:
4839:
4834:
4830:
4816:
4813:
4811:
4808:
4806:
4803:
4801:
4798:
4796:
4793:
4791:
4788:
4786:
4783:
4779:
4776:
4774:
4771:
4769:
4766:
4764:
4761:
4760:
4759:
4756:
4755:
4753:
4750:
4746:
4739:
4738:
4736:
4733:
4729:
4722:
4721:
4719:
4716:
4712:
4705:
4704:
4702:
4699:
4695:
4689:
4686:
4684:
4681:
4679:
4676:
4675:
4673:
4670:
4666:
4660:
4657:
4655:
4652:
4648:
4645:
4643:
4640:
4638:
4635:
4633:
4630:
4628:
4625:
4623:
4620:
4618:
4615:
4614:
4613:
4610:
4606:
4603:
4601:
4598:
4596:
4593:
4591:
4588:
4587:
4586:
4583:
4579:
4576:
4574:
4571:
4569:
4566:
4564:
4561:
4559:
4556:
4554:
4551:
4549:
4546:
4544:
4541:
4540:
4539:
4536:
4535:
4533:
4530:
4526:
4518:
4515:
4513:
4510:
4508:
4505:
4504:
4503:
4500:
4496:
4493:
4491:
4488:
4486:
4483:
4482:
4481:
4478:
4474:
4471:
4469:
4466:
4464:
4461:
4459:
4456:
4454:
4451:
4449:
4446:
4444:
4441:
4440:
4439:
4436:
4435:
4433:
4430:
4426:
4420:
4417:
4415:
4412:
4410:
4407:
4405:
4402:
4400:
4397:
4395:
4392:
4390:
4387:
4385:
4382:
4380:
4377:
4376:
4374:
4371:
4367:
4361:
4358:
4356:
4353:
4351:
4348:
4346:
4343:
4341:
4338:
4336:
4333:
4331:
4328:
4326:
4323:
4321:
4318:
4316:
4313:
4311:
4308:
4306:
4303:
4301:
4298:
4296:
4293:
4291:
4288:
4286:
4283:
4281:
4278:
4276:
4273:
4271:
4268:
4267:
4265:
4262:
4258:
4252:
4249:
4247:
4244:
4242:
4239:
4237:
4234:
4233:
4231:
4228:
4224:
4220:
4215:
4210:
4206:
4192:
4189:
4187:
4184:
4182:
4179:
4177:
4174:
4173:
4171:
4168:
4164:
4158:
4155:
4153:
4150:
4149:
4147:
4144:
4140:
4134:
4131:
4129:
4126:
4124:
4121:
4119:
4116:
4114:
4111:
4110:
4108:
4105:
4101:
4095:
4092:
4090:
4087:
4085:
4082:
4080:
4077:
4076:
4074:
4071:
4067:
4061:
4058:
4056:
4053:
4051:
4048:
4046:
4043:
4041:
4038:
4036:
4033:
4031:
4028:
4026:
4023:
4021:
4018:
4016:
4013:
4011:
4008:
4006:
4003:
4001:
3998:
3996:
3993:
3991:
3988:
3986:
3983:
3981:
3978:
3976:
3973:
3971:
3968:
3966:
3963:
3961:
3958:
3956:
3953:
3951:
3948:
3946:
3943:
3941:
3938:
3936:
3933:
3931:
3928:
3926:
3923:
3921:
3918:
3916:
3913:
3911:
3908:
3906:
3903:
3901:
3898:
3896:
3893:
3891:
3888:
3886:
3883:
3881:
3878:
3876:
3873:
3871:
3868:
3866:
3863:
3861:
3858:
3856:
3853:
3851:
3848:
3846:
3843:
3841:
3838:
3836:
3833:
3831:
3828:
3826:
3823:
3821:
3818:
3816:
3813:
3811:
3808:
3806:
3803:
3801:
3798:
3796:
3793:
3791:
3788:
3786:
3783:
3782:
3780:
3777:
3773:
3767:
3764:
3762:
3759:
3757:
3754:
3753:
3751:
3748:
3744:
3738:
3735:
3733:
3730:
3729:
3727:
3724:
3720:
3714:
3711:
3710:
3708:
3705:
3701:
3695:
3692:
3690:
3687:
3685:
3682:
3680:
3677:
3675:
3672:
3670:
3667:
3665:
3662:
3660:
3657:
3655:
3652:
3650:
3647:
3645:
3642:
3640:
3637:
3635:
3632:
3631:
3629:
3626:
3622:
3616:
3613:
3611:
3608:
3607:
3605:
3602:
3598:
3592:
3589:
3587:
3584:
3582:
3579:
3577:
3574:
3572:
3569:
3568:
3566:
3563:
3559:
3553:
3550:
3548:
3545:
3543:
3540:
3538:
3535:
3533:
3530:
3528:
3525:
3524:
3522:
3519:
3515:
3508:
3507:
3505:
3503:(EC 2.7.11.9)
3502:
3498:
3492:
3489:
3487:
3484:
3483:
3481:
3479:(EC 2.7.11.8)
3478:
3474:
3466:
3463:
3461:
3458:
3456:
3453:
3452:
3451:
3450:Aurora kinase
3448:
3447:
3445:
3443:(EC 2.7.11.7)
3442:
3438:
3432:
3429:
3428:
3426:
3424:(EC 2.7.11.6)
3423:
3419:
3413:
3410:
3408:
3405:
3403:
3400:
3398:
3395:
3394:
3392:
3390:(EC 2.7.11.5)
3389:
3385:
3379:
3376:
3374:
3371:
3369:
3366:
3365:
3363:
3361:(EC 2.7.11.4)
3360:
3356:
3348:
3345:
3343:
3340:
3338:
3335:
3334:
3332:
3328:
3325:
3323:
3320:
3319:
3317:
3313:
3310:
3308:
3305:
3304:
3302:
3299:
3298:
3296:
3294:(EC 2.7.11.3)
3293:
3289:
3283:
3280:
3278:
3275:
3273:
3270:
3268:
3265:
3264:
3262:
3260:(EC 2.7.11.2)
3259:
3255:
3247:
3244:
3243:
3242:
3239:
3235:
3232:
3230:
3227:
3225:
3222:
3220:
3217:
3216:
3215:
3214:EIF-2 kinases
3212:
3210:
3207:
3205:
3202:
3198:
3195:
3193:
3190:
3188:
3185:
3184:
3183:
3180:
3178:
3175:
3173:
3170:
3168:
3165:
3163:
3160:
3158:
3155:
3153:
3150:
3148:
3145:
3143:
3140:
3138:
3135:
3133:
3130:
3128:
3125:
3124:
3122:
3120:(EC 2.7.11.1)
3119:
3115:
3111:
3106:
3101:
3097:
3092:
3088:
3084:
3077:
3072:
3070:
3065:
3063:
3058:
3057:
3054:
3040:
3037:
3036:
3035:
3032:
3031:
3029:
3025:
3019:
3016:
3012:
3009:
3007:
3004:
3003:
3002:
2999:
2998:
2996:
2994:
2990:
2984:
2980:
2977:
2976:
2974:
2972:
2968:
2956:
2953:
2951:
2948:
2946:
2943:
2942:
2941:
2938:
2937:
2934:
2928:
2924:
2921:
2920:
2917:
2909:
2906:
2905:
2904:
2901:
2900:
2897:
2891:
2888:
2887:
2884:
2876:
2873:
2871:
2868:
2866:
2863:
2862:
2861:
2860:
2854:
2851:
2850:
2847:
2839:
2836:
2834:
2831:
2829:
2826:
2824:
2821:
2820:
2819:
2816:
2815:
2812:
2809:
2807:
2803:
2795:
2792:
2790:
2787:
2786:
2785:
2782:
2778:
2775:
2773:
2770:
2769:
2768:
2765:
2761:
2758:
2756:
2753:
2752:
2751:
2747:
2744:
2743:
2741:
2739:
2735:
2729:
2726:
2724:
2720:
2717:
2716:
2714:
2712:
2708:
2704:
2700:
2693:
2688:
2686:
2681:
2679:
2674:
2673:
2670:
2658:
2655:
2654:
2652:
2648:
2642:
2639:
2637:
2634:
2633:
2631:
2629:
2625:
2619:
2616:
2614:
2611:
2609:
2606:
2604:
2601:
2599:
2596:
2594:
2591:
2589:
2586:
2584:
2581:
2579:
2576:
2574:
2571:
2570:
2568:
2566:
2562:
2556:
2553:
2550:
2547:
2545:
2541:
2538:
2535:
2532:
2530:
2527:
2525:
2522:
2520:
2517:
2515:
2511:
2508:
2507:
2505:
2503:
2499:
2495:
2485:
2482:
2481:
2479:
2475:
2469:
2466:
2464:
2461:
2457:
2454:
2452:
2449:
2448:
2447:
2444:
2443:
2441:
2437:
2429:
2426:
2424:
2421:
2420:
2419:
2416:
2414:
2411:
2407:
2404:
2402:
2399:
2397:
2394:
2393:
2392:
2389:
2388:
2386:
2382:
2379:
2376:
2372:
2368:
2363:
2359:
2349:
2346:
2342:
2339:
2337:
2334:
2332:
2329:
2327:
2324:
2322:
2319:
2317:
2314:
2312:
2309:
2307:
2304:
2302:
2299:
2297:
2294:
2292:
2289:
2288:
2287:
2284:
2280:
2277:
2275:
2272:
2270:
2267:
2265:
2262:
2260:
2257:
2255:
2252:
2250:
2247:
2245:
2242:
2240:
2237:
2235:
2232:
2231:
2230:
2227:
2226:
2224:
2222:
2217:
2211:
2208:
2204:
2201:
2199:
2196:
2194:
2191:
2189:
2186:
2185:
2184:
2181:
2177:
2174:
2172:
2169:
2167:
2164:
2163:
2162:
2159:
2158:
2156:
2154:
2150:
2145:
2142:
2140:
2136:
2132:
2128:
2121:
2116:
2114:
2109:
2107:
2102:
2101:
2098:
2091:
2087:
2086:
2081:
2080:
2075:
2073:
2070:
2068:
2065:
2063:
2060:
2059:
2055:
2047:
2043:
2038:
2033:
2029:
2025:
2021:
2013:
2010:
1998:
1994:
1987:
1985:
1983:
1979:
1974:
1970:
1965:
1960:
1956:
1952:
1948:
1944:
1940:
1933:
1930:
1925:
1921:
1916:
1911:
1907:
1903:
1899:
1895:
1891:
1887:
1883:
1876:
1873:
1868:
1864:
1859:
1854:
1851:(1): 115–29.
1850:
1846:
1842:
1835:
1832:
1827:
1823:
1818:
1813:
1809:
1805:
1801:
1797:
1793:
1786:
1783:
1778:
1774:
1769:
1764:
1760:
1756:
1755:Endocrinology
1752:
1745:
1742:
1737:
1733:
1728:
1723:
1719:
1715:
1711:
1707:
1703:
1696:
1693:
1688:
1684:
1679:
1674:
1670:
1666:
1662:
1658:
1654:
1647:
1645:
1641:
1636:
1632:
1626:
1623:
1618:
1614:
1608:
1605:
1601:
1597:
1592:
1590:
1588:
1584:
1580:
1576:
1571:
1569:
1567:
1563:
1557:
1555:
1552:
1550:
1545:
1541:
1539:
1535:
1527:
1525:
1521:
1519:
1515:
1511:
1506:
1498:
1496:
1494:
1490:
1486:
1477:
1475:
1473:
1469:
1465:
1461:
1457:
1453:
1449:
1445:
1441:
1437:
1433:
1429:
1425:
1421:
1409:
1404:
1400:
1396:
1393:
1389:
1382:
1380:
1377:
1373:
1369:
1365:
1362:
1358:
1354:
1347:
1345:
1339:
1335:
1332:
1326:
1324:
1318:
1314:
1311:
1307:
1300:
1298:
1292:
1288:
1285:
1279:
1277:
1273:
1267:
1263:
1260:
1258:RefSeq (mRNA)
1256:
1249:
1248:
1243:
1239:
1236:
1230:
1229:
1224:
1220:
1217:
1215:
1211:
1204:
1203:
1198:
1194:
1191:
1185:
1184:
1179:
1175:
1172:
1170:
1166:
1159:
1158:
1153:
1149:
1146:
1140:
1139:
1134:
1130:
1127:
1125:
1121:
1118:
1115:
1113:
1110:
1106:
1103:
1099:
1095:
1088:
1084:
1079:
1073:
1070:
1068:
1065:
1063:
1060:
1058:
1055:
1053:
1050:
1048:
1045:
1043:
1040:
1038:
1035:
1033:
1030:
1028:
1025:
1023:
1020:
1018:
1015:
1013:
1010:
1008:
1005:
1003:
1000:
998:
995:
993:
990:
988:
985:
983:
980:
978:
975:
973:
970:
968:
965:
963:
960:
958:
955:
953:
950:
948:
945:
943:
940:
938:
935:
933:
930:
928:
925:
923:
920:
918:
915:
913:
910:
908:
905:
903:
900:
898:
895:
893:
890:
888:
885:
883:
880:
878:
875:
873:
870:
868:
865:
863:
860:
858:
855:
853:
850:
848:
845:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
764:
762:
759:
758:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
673:
671:
668:
667:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
596:
593:
591:
588:
586:
583:
582:
580:
577:
576:
573:
572:Gene ontology
569:
565:
553:
548:
545:
543:
539:
531:
526:
515:
511:
507:
503:
499:
495:
491:
487:
483:
479:
478:
475:
471:
466:
463:
453:
449:
446:skin of thigh
445:
441:
437:
433:
429:
425:
421:
417:
416:
413:
409:
404:
401:
400:
397:
395:
391:
389:
388:
384:
383:
380:
378:
374:
370:
366:
362:
354:
349:
345:
341:
336:
326:
322:
315:
308:
302:
295:
287:
283:
279:
274:
270:
265:
261:
253:
248:
244:
240:
235:
225:
221:
214:
207:
201:
194:
190:
184:
180:
176:
171:
167:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
110:
105:
98:
93:
88:
77:
75:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
6812:
6795:
6730:
6675:
6638:
6610:
6578:Antagonists:
6577:
6476:
6453:
6421:Antagonists:
6420:
6296:
6260:Antagonists:
6259:
6191:
6181:
6163:
6152:Lerdelimumab
6147:Fresolimumab
6143:
6105:
6059:
6041:Antagonists:
6040:
6012:
5974:
5890:
5807:
5796:Lerdelimumab
5791:Fresolimumab
5787:
5745:
5707:
5675:Antagonists:
5674:
5623:
5585:
5531:
5483:
5401:
5373:
5367:Dalantercept
5363:
5348:
5338:
5267:
5182:Translocases
5179:
5166:
5153:
5140:
5127:
5117:Transferases
5114:
5101:
4958:Binding site
4777:
4389:P70S6 kinase
2856:
2793:
2467:
2084:
2078:
2027:
2023:
2012:
2000:. Retrieved
1996:
1946:
1942:
1932:
1892:(1): 18577.
1889:
1885:
1875:
1848:
1845:Reproduction
1844:
1834:
1799:
1795:
1785:
1758:
1754:
1744:
1709:
1705:
1695:
1660:
1656:
1634:
1625:
1616:
1607:
1553:
1548:
1546:
1542:
1533:
1531:
1522:
1502:
1481:
1452:osteogenesis
1431:
1423:
1419:
1418:
1341:
1320:
1294:
1269:
1245:
1226:
1200:
1181:
1155:
1136:
1116:
1111:
706:cell surface
660:SMAD binding
512:pineal gland
492:carotid body
484:ciliary body
480:cumulus cell
392:
385:
250:202,567,751
237:202,376,327
229:2q33.1-q33.2
112:External IDs
67:
6796:Antibodies:
6759:Follistatin
6614:Ramatercept
6457:Sotatercept
6157:Metelimumab
6144:Antibodies:
5801:Metelimumab
5788:Antibodies:
5377:Disitertide
5339:Antibodies:
4953:Active site
4840:(EC 2.7.12)
4227:Polo kinase
4167:Polo kinase
3034:Somatomedin
2903:Somatomedin
2746:TGF pathway
2628:Coreceptors
2588:Follistatin
2498:Transducers
2024:Circulation
1493:equilibrium
1464:BMP pathway
1456:cell growth
741:nucleoplasm
605:BMP binding
590:ATP binding
450:skin of hip
351:59,918,173
338:59,802,559
330:1|1 C2
90:Identifiers
6879:S/T kinase
6853:Categories
6799:Stamulumab
6749:DAN (PARN)
6668:(β-glycan)
6571:Radotermin
6414:Radotermin
6394:11 (BMP11)
6350:15 (GDF9B)
6253:Radotermin
6118:10 (BMP3B)
6028:11 (BMP11)
5968:Radotermin
5926:15 (GDF9B)
5831:LY-2109761
5762:11 (BMP11)
5758:10 (BMP3B)
5657:11 (BMP11)
5236:modulators
5156:Isomerases
5130:Hydrolases
4997:Regulation
3518:IκB kinase
3093:2.7.11-12)
2484:betaglycan
2219:Ligand of
2147:Ligand of
2002:29 January
1602:, May 2017
1581:, May 2017
1558:References
442:right lung
396:(ortholog)
133:HomoloGene
6889:EC 2.7.11
6884:Receptors
6874:TS domain
6679:Avotermin
6642:AMH (MIS)
6639:Agonists:
6550:7 (BMP12)
6546:6 (BMP13)
6542:5 (BMP14)
6477:Agonists:
6386:7 (BMP12)
6382:6 (BMP13)
6378:5 (BMP14)
6297:Agonists:
6247:7 (BMP12)
6243:6 (BMP13)
6239:5 (BMP14)
6192:Agonists:
6172:LY-364947
6109:Avotermin
6106:Agonists:
6073:SB-505124
6068:SB-431542
6013:Agonists:
5954:7 (BMP12)
5950:6 (BMP13)
5946:5 (BMP14)
5891:Agonists:
5861:SB-525334
5856:SB-505124
5851:SB-431542
5826:LY-364947
5821:GW-788388
5749:Avotermin
5746:Agonists:
5721:SB-505124
5716:SB-431542
5624:Agonists:
5535:AMH (MIS)
5532:Agonists:
5428:Avotermin
5423:AMH (MIS)
5402:Agonists:
5289:Avotermin
5268:Agonists:
5035:EC number
3644:PKC alpha
2699:Receptors
1514:ovulation
1505:granulosa
1344:NP_031587
1323:NP_001195
1297:NM_007561
1276:NM_033346
1272:NM_001204
1102:Orthologs
721:cytoplasm
141:GeneCards
6816:Endoglin
6724:Unsorted
6676:Ligands:
6656:Type III
6235:2 (BMP9)
5841:R-268712
5313:2 (BMP9)
5304:Cetermin
5059:Kinetics
4983:Cofactor
4946:Activity
4000:KIAA0999
3895:MAPKAPK5
3890:MAPKAPK3
3885:MAPKAPK2
2750:TGF-beta
2573:Cerberus
2046:19307479
2018:(2009).
1973:23202738
1924:31819097
1867:19359354
1826:22825968
1777:18063682
1736:10880444
1687:10712517
1598:–
1577:–
1510:follicle
1478:Function
1440:TGF beta
1392:Wikidata
1081:Sources:
701:membrane
691:dendrite
6843:Biology
6813:Others:
6754:Decorin
6744:Chordin
6684:Inhibin
6581:Inhibin
6480:Activin
6424:Inhibin
6300:Activin
6263:Inhibin
6087:Type II
6063:A 83-01
5988:K-02288
5811:A 83-01
5711:A 83-01
5678:Inhibin
5627:Activin
5599:K-02288
5502:K-02288
5405:Activin
5352:K-02288
5271:Activin
5169:Ligases
4939:Enzymes
4659:MAP3K14
4637:MAP3K11
4632:MAP3K10
4622:MAP3K13
4617:MAP3K12
4419:RPS6KC1
4414:RPS6KA1
4409:RPS6KA3
4404:RPS6KA2
4399:RPS6KB2
4384:RPS6KA4
4379:RPS6KA5
4030:Kalirin
3995:SNF1LK2
3234:EIF2AK4
3229:EIF2AK3
3083:Kinases
2767:Activin
2593:Gremlin
2583:Decorin
2578:Chordin
2477:TGFBR3:
2439:TGFBR2:
2384:TGFBR1:
2367:Activin
1964:3533531
1915:6901466
1894:Bibcode
1817:3492567
1600:Ensembl
1579:Ensembl
1444:ligands
1214:UniProt
1169:Ensembl
1108:Species
1087:QuickGO
681:caveola
430:urethra
371:pattern
129:1095407
97:Aliases
6829:Portal
6805:TRC105
6774:Noggin
6666:TGFβR3
6468:ACVR2B
6283:ACVR2A
6097:TGFβR2
6003:ACVR1C
5881:BMPR1B
5866:SD-208
5816:D-4476
5736:TGFβR1
5614:ACVR1B
5522:BMPR1A
5392:ACVR1A
5258:ACVRL1
5244:Type I
5143:Lyases
4889:MAP2K7
4884:MAP2K6
4879:MAP2K5
4874:MAP2K4
4869:MAP2K3
4864:MAP2K2
4859:MAP2K1
4810:ACVRL1
4805:ACVR2B
4800:ACVR2A
4795:ACVR1C
4790:ACVR1B
4773:BMPR1B
4768:BMPR1A
4642:MAP3K7
4627:MAP3K9
4578:MAP3K8
4573:MAP3K7
4568:MAP3K6
4563:MAP3K5
4558:MAP3K4
4553:MAP3K3
4548:MAP3K2
4543:MAP3K1
4517:MAPK14
4512:MAPK13
4507:MAPK11
4495:MAPK10
4473:MAPK15
4468:MAPK12
4360:CDC2L1
4335:CDC2L5
4010:SNF1LK
3835:CAMK2G
3830:CAMK2D
3825:CAMK2B
3820:CAMK2A
3810:CAMK1G
3805:CAMK1D
3800:CAMK1B
3795:CAMK1A
3649:PRKCB1
3586:PRKACA
3581:PRKACB
3576:PRKACG
3552:IKBKAP
3378:BCKDHB
3373:BCKDHA
3347:PRKAG3
3342:PRKAG2
3337:PRKAG1
3327:PRKAB2
3322:PRKAB1
3312:PRKAA2
3307:PRKAA1
3152:STK38L
2641:Cripto
2608:Noggin
2540:I-SMAD
2510:R-SMAD
2456:ACVR2B
2451:ACVR2A
2428:BMPR1B
2423:BMPR1A
2413:ACVRL1
2406:ACVR1C
2401:ACVR1B
2375:family
2176:TGF-β3
2171:TGF-β2
2166:TGF-β1
2076:Human
2044:
1971:
1961:
1922:
1912:
1865:
1824:
1814:
1775:
1734:
1727:313944
1724:
1706:EMBO J
1685:
1675:
1489:ligand
1472:R-SMAD
1378:search
1376:PubMed
1247:O35607
1228:Q13873
1124:Entrez
542:BioGPS
121:600799
6769:LTBP1
6734:BAMBI
6625:AMHR2
6595:Lefty
6561:Nodal
6438:Lefty
6409:Nodal
6287:ACVR2
6183:BMPR2
6167:DMH-2
6044:Lefty
6034:Nodal
5978:DMH-2
5692:Lefty
5668:Nodal
5589:DMH-2
5492:DMH-2
5487:DMH-1
5095:Types
4851:MAP2K
4785:ACVR1
4778:BMPR2
4763:BMPR1
4688:GSK-3
4529:MAP3K
4490:MAPK9
4485:MAPK8
4463:MAPK7
4458:MAPK6
4453:MAPK4
4448:MAPK3
4443:MAPK1
4355:PFTK1
4350:PCTK3
4345:PCTK2
4340:PCTK1
4330:CDK12
4325:CDK10
4300:CDKL5
4280:CDKL2
4157:STK19
4152:EEF2K
4133:PHKG2
4128:PHKG1
4118:PHKA2
4113:PHKA1
4094:MYLK4
4089:MYLK3
4084:MYLK2
4060:DCLK1
4055:Titin
4045:TRIB3
4040:TRIB2
4035:TRIB1
4025:TSSK2
4005:STK40
3990:PSKH1
3985:PRKD3
3980:PRKD2
3960:PHKG2
3955:PHKG1
3945:OBSCN
3940:NUAK2
3935:NUAK1
3930:MKNK2
3925:MKNK1
3915:MARK4
3910:MARK3
3905:MARK2
3900:MARK1
3880:STK11
3875:DAPK3
3870:DAPK2
3865:DAPK1
3860:CHEK2
3855:CHEK1
3840:CAMK4
3815:CAMK2
3790:CAMK1
3785:BRSK2
3679:PRKCQ
3674:PRKCI
3669:PRKCG
3664:PRKCH
3659:PRKCE
3654:PRKCD
3615:PRKG1
3547:IKBKG
3542:IKBKE
3491:STK10
3486:FASTK
3412:IDH3G
3407:IDH3B
3402:IDH3A
3368:BCKDK
3162:ROCK1
3147:STK38
3142:MAST2
3137:MAST1
3132:LATS2
3127:LATS1
2650:Other
2636:BAMBI
2618:THBS1
2603:LTBP1
2598:Lefty
2555:SMAD4
2549:SMAD7
2544:SMAD6
2534:SMAD9
2529:SMAD5
2524:SMAD3
2519:SMAD2
2514:SMAD1
2468:BMPR2
2463:AMHR2
2418:BMPR1
2396:ACVR1
2341:GDF15
2336:GDF11
2331:GDF10
2279:BMP15
2274:BMP10
2269:BMP8b
2264:BMP8a
2210:Nodal
2203:INHBC
2198:INHBB
2193:INHBA
2153:TGFBR
2085:BMPR2
2079:BMPR2
1678:14828
1549:BMPR2
1534:BMPR2
1432:BMPR2
1426:is a
1424:BMPR2
1157:12168
1117:Mouse
1112:Human
1083:Amigo
504:molar
394:Mouse
387:Human
334:Start
269:Mouse
233:Start
166:Human
145:BMPR2
104:BMPR2
22:BMPR2
6779:TGIF
6698:TGFβ
6629:AMHR
6124:TGFβ
5999:ALK7
5877:ALK6
5768:TGFβ
5732:ALK5
5610:ALK4
5518:ALK3
5464:TGFβ
5388:ALK2
5319:TGFβ
5254:ALK1
5231:TGFβ
5187:list
5180:EC7
5174:list
5167:EC6
5161:list
5154:EC5
5148:list
5141:EC4
5135:list
5128:EC3
5122:list
5115:EC2
5109:list
5102:EC1
4678:TPK1
4654:CDC7
4612:MLKs
4605:KSR2
4600:KSR1
4595:BRAF
4590:ARAF
4585:RAFs
4320:CDK9
4315:CDK8
4310:CDK7
4305:CDK6
4295:CDK5
4290:CDK4
4285:CDK3
4275:CDK2
4270:CDK1
4251:PLK4
4246:PLK3
4241:PLK2
4236:PLK1
4191:PLK4
4186:PLK3
4181:PLK2
4176:PLK1
4123:PHKB
4079:MYLK
4050:TRIO
4020:SPEG
4015:SNRK
3975:PKD1
3970:PIM2
3965:PIM1
3950:PASK
3920:MELK
3850:CASK
3845:MLCK
3766:GRK6
3761:GRK5
3756:GRK4
3694:PKN3
3689:PKN2
3591:PRKY
3537:TBK1
3532:IKK2
3527:CHUK
3431:STK4
3397:IDH2
3282:PDK4
3277:PDK3
3272:PDK2
3267:PDK1
3246:WEE1
3241:Wee1
3209:mTOR
3197:AKT3
3192:AKT2
3187:AKT1
3177:SGK3
3172:SGK2
2940:VEGF
2923:ErbB
2875:TrkC
2870:TrkB
2865:TrkA
2657:SARA
2613:PARN
2502:SMAD
2326:GDF9
2316:GDF7
2311:GDF6
2306:GDF5
2301:GDF3
2296:GDF2
2291:GDF1
2259:BMP7
2254:BMP6
2249:BMP5
2244:BMP4
2239:BMP3
2234:BMP2
2221:BMPR
2188:INHA
2149:ACVR
2042:PMID
2004:2015
1969:PMID
1920:PMID
1863:PMID
1822:PMID
1773:PMID
1732:PMID
1683:PMID
1458:and
488:iris
377:Bgee
325:Band
286:Chr.
224:Band
183:Chr.
117:OMIM
74:3G2F
70:2HLQ
51:RCSB
48:PDBe
6530:GDF
6498:BMP
6366:GDF
6318:BMP
6231:GDF
6195:BMP
6114:GDF
6016:GDF
5942:GDF
5894:BMP
5754:GDF
5645:GDF
5540:BMP
5433:BMP
5309:GDF
5294:BMP
4683:TTK
4647:ZAK
3224:HRI
3219:PKR
3167:SGK
3157:CIT
2859:Trk
2371:BMP
2151:or
2032:doi
2028:119
1959:PMC
1951:doi
1947:122
1910:PMC
1902:doi
1853:doi
1849:138
1812:PMC
1804:doi
1763:doi
1759:149
1722:PMC
1714:doi
1673:PMC
1665:doi
1422:or
1138:659
550:n/a
347:End
246:End
149:OMA
137:929
125:MGI
41:PDB
6855::
6708:,
6704:,
6690:,
6601:,
6587:,
6548:,
6544:,
6540:,
6536:,
6512:,
6508:,
6504:,
6492:AB
6490:,
6486:,
6444:,
6430:,
6398:15
6396:,
6392:,
6388:,
6384:,
6380:,
6376:,
6372:,
6348:,
6346:8B
6344:,
6342:8A
6340:,
6336:,
6332:,
6328:,
6324:,
6312:AB
6310:,
6306:,
6269:,
6245:,
6241:,
6237:,
6215:10
6213:,
6209:,
6205:,
6201:,
6134:,
6130:,
6050:,
6026:,
6022:,
5962:15
5960:,
5956:,
5952:,
5948:,
5924:,
5922:8B
5920:,
5918:8A
5916:,
5912:,
5908:,
5904:,
5900:,
5778:,
5774:,
5760:,
5698:,
5684:,
5655:,
5651:,
5639:AB
5637:,
5633:,
5568:8B
5566:,
5564:8A
5562:,
5558:,
5554:,
5550:,
5546:,
5474:,
5470:,
5453:8B
5451:,
5449:8A
5447:,
5443:,
5439:,
5417:AB
5415:,
5411:,
5329:,
5325:,
5298:10
5283:AB
5281:,
5277:,
3333:γ
3318:β
3303:α
3091:EC
3085::
2981::
2855::
2748::
2721::
2701::
2373:,
2369:,
2129::
2040:.
2026:.
2022:.
1995:.
1981:^
1967:.
1957:.
1945:.
1941:.
1918:.
1908:.
1900:.
1888:.
1884:.
1861:.
1847:.
1843:.
1820:.
1810:.
1800:29
1798:.
1794:.
1771:.
1757:.
1753:.
1730:.
1720:.
1710:19
1708:.
1704:.
1681:.
1671:.
1661:11
1659:.
1655:.
1643:^
1633:.
1615:.
1586:^
1565:^
1540:.
1454:,
1085:/
353:bp
340:bp
252:bp
239:bp
147:;
143::
139:;
135::
131:;
127::
123:;
119::
72:,
6831::
6712:)
6710:3
6706:2
6702:1
6700:(
6694:)
6692:B
6688:A
6686:(
6631:)
6627:(
6605:)
6603:2
6599:1
6597:(
6591:)
6589:B
6585:A
6583:(
6552:)
6538:3
6534:1
6532:(
6516:)
6514:7
6510:6
6506:4
6502:2
6500:(
6494:)
6488:B
6484:A
6482:(
6448:)
6446:2
6442:1
6440:(
6434:)
6432:B
6428:A
6426:(
6400:)
6390:9
6374:3
6370:1
6368:(
6352:)
6338:7
6334:6
6330:5
6326:4
6322:2
6320:(
6314:)
6308:B
6304:A
6302:(
6289:)
6285:(
6273:)
6271:B
6267:A
6265:(
6249:)
6233:(
6217:)
6211:7
6207:6
6203:4
6199:2
6197:(
6138:)
6136:3
6132:2
6128:1
6126:(
6120:)
6116:(
6054:)
6052:2
6048:1
6046:(
6030:)
6024:3
6020:1
6018:(
6005:)
6001:(
5964:)
5958:9
5944:(
5928:)
5914:7
5910:6
5906:5
5902:4
5898:2
5896:(
5883:)
5879:(
5782:)
5780:3
5776:2
5772:1
5770:(
5764:)
5756:(
5738:)
5734:(
5702:)
5700:2
5696:1
5694:(
5688:)
5686:B
5682:A
5680:(
5659:)
5653:3
5649:1
5647:(
5641:)
5635:B
5631:A
5629:(
5616:)
5612:(
5570:)
5560:7
5556:6
5552:5
5548:4
5544:2
5542:(
5524:)
5520:(
5478:)
5476:3
5472:2
5468:1
5466:(
5455:)
5445:7
5441:6
5437:5
5435:(
5419:)
5413:B
5409:A
5407:(
5394:)
5390:(
5333:)
5331:3
5327:2
5323:1
5321:(
5315:)
5311:(
5300:)
5296:(
5285:)
5279:B
5275:A
5273:(
5260:)
5256:(
5222:e
5215:t
5208:v
5189:)
5185:(
5176:)
5172:(
5163:)
5159:(
5150:)
5146:(
5137:)
5133:(
5124:)
5120:(
5111:)
5107:(
4931:e
4924:t
4917:v
4740:-
4723:-
4706:-
3509:-
3089:(
3075:e
3068:t
3061:v
3011:B
3006:A
2955:3
2950:2
2945:1
2925:/
2838:4
2833:3
2828:2
2823:1
2794:2
2789:1
2777:2
2772:1
2760:2
2755:1
2691:e
2684:t
2677:v
2551:)
2542:(
2536:)
2512:(
2500:/
2377:)
2365:(
2119:e
2112:t
2105:v
2092:.
2048:.
2034::
2006:.
1975:.
1953::
1926:.
1904::
1896::
1890:9
1869:.
1855::
1828:.
1806::
1779:.
1765::
1738:.
1716::
1689:.
1667::
1637:.
1619:.
271:)
168:)
151::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
