255:
232:
129:
154:
506:
261:
160:
1115:, an autosomal recessive skin disease with variable clinical phenotypes. Morphological characteristics of junctional epidermolysis bullosa are rudimentary hemidesmosomes and subepidermal tissue separation. Clinical hallmarks, in addition to blisters and erosions of the skin and mucous membranes, include nail dystrophy, loss of hair, and dental anomalies.
1126:(HG), both acquired subepithelial blistering disorders. Most immunodominant epitopes lie within the NC16A domain, and the binding of the autoantibodies perturbs adhesive functions of the collagen XVII, and this (together with inflammation-related processes) leads to epidermal-dermal separation and skin blistering.
1091:
intermediate filaments. The large C-terminal ectodomain with a molecular mass of approximately 120 kDa consists of 15 collagenous subdomains, characterized by typical collagenous G-X-Y repeat sequences, flanked by 16 short non-collagenous stretches. The overall structure of the ectodomain is that of
1158:
Collagen XVII is constitutively shed from the keratinocyte surface within NC16A domain by TACE (TNF-Alpha
Converting Enzyme), metalloproteinase of the ADAM family. The shedding is lipid raft dependent. Collagen XVII is extracellularly phosphorylated by ecto-casein kinase 2 within the NC16A domain,
1096:
with a significant thermal stability. The membrane proximal part of the ectodomain, within amino acids 506-519, is responsible for binding to alpha 6 integrin, this binding seems to be important for the collagen XVII integration into hemidesmosomes . The largest collagenous domain, Col15, which
1149:
Expression of the COL17A1 gene is abnormal in various cancers. For example, it was found abnormal in five epithelial cancer types, including breast cancer, cervical cancer, head and neck cancer and two types of lung cancer. Decreased expression was observed for breast cancer, while increased
1063:, and expression of this gene is abnormal in various cancers. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form.
1111:, lead to the absence or structural alterations and mutations of collagen XVII. The functional consequences include diminished epidermal adhesion and skin blistering in response to minimal shearing forces. The disorder caused by biallelic COL17A1 mutations and is called junctional
1052:. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. It also appears to be a key protein in maintaining the integrity of the
1097:
contains 232 amino acids (amino acids 567-808), contributes significantly to stability of collagen XVII homotrimer. The C-terminus of collagen XVII binds to laminin 5, and correct integration of laminin 5 into the matrix requires collagen XVII.
1037:, is a transmembrane protein which plays a critical role in maintaining the linkage between the intracellular and the extracellular structural elements involved in epidermal adhesion, identified by Diaz and colleagues in 1990.
2791:
McGrath JA, Gatalica B, Christiano AM, et al. (1995). "Mutations in the 180-kD bullous pemphigoid antigen (BPAG2), a hemidesmosomal transmembrane collagen (COL17A1), in generalized atrophic benign epidermolysis bullosa".
2490:
Koster J, Geerts Dirk, Favre
Bertrand, Borradori Luca, Sonnenberg Arnoud (January 2003). "Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly".
2172:"Whole exome sequencing and segregation analysis confirms that a mutation in COL17A1 is the cause of epithelial recurrent erosion dystrophy in a large dominant pedigree previously mapped to chromosome 10q23-q24"
1074:
XVII is a homotrimer of three alpha1(XVII)-chains and a transmembrane protein in type II orientation. Each 180 kD a-chain contains a globular intracellular domain of approximately 70 kDa, which interacts with
3222:"Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180"
2638:"Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180"
2895:"Compound heterozygosity for a dominant glycine substitution and a recessive internal duplication mutation in the type XVII collagen gene results in junctional epidermolysis bullosa and abnormal dentition"
2021:
Giudice GJ, Emery DJ, Zelickson BD, Anhalt GJ, Liu Z, Diaz LA (1993-11-15). "Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain".
1667:"The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome"
2593:
Aho S, Uitto J (February 1998). "Direct interaction between the intracellular domains of bullous pemphigoid antigen 2 (BP180) and beta 4 integrin, hemidesmosomal components of basal keratinocytes".
1966:"Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome"
1361:"Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome"
3129:"Cycloheximide facilitates the identification of aberrant transcripts resulting from a novel splice-site mutation in COL17A1 in a patient with generalized atrophic benign epidermolysis bullosa"
3162:
Aho S, Uitto J (1998). "Direct interaction between the intracellular domains of bullous pemphigoid antigen 2 (BP180) and beta 4 integrin, hemidesmosomal components of basal keratinocytes".
1133:(ERED). Whole-exome sequencing first identified a heterozygous mutation (c.2816C>T, p.T939I) that segregated with ERED in a large Swedish pedigree dating back 200 years. Another
3094:"A homozygous in-frame deletion in the collagenous domain of bullous pemphigoid antigen BP180 (type XVII collagen) causes generalized atrophic benign epidermolysis bullosa"
3008:"The localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the beta4 integrin subunit"
268:
167:
2729:"Genomic organization of collagenous domains and chromosomal assignment of human 180-kDa bullous pemphigoid antigen-2, a novel collagen of stratified squamous epithelium"
3265:"97 kDa linear IgA bullous dermatosis antigen localizes in the lamina lucida between the NC16A and carboxyl terminal domains of the 180 kDa bullous pemphigoid antigen"
3051:"Three novel homozygous point mutations and a new polymorphism in the COL17A1 gene: relation to biological and clinical phenotypes of junctional epidermolysis bullosa"
2542:
Aho S, Rothenberger K, Uitto J (June 1999). "Human p120ctn catenin: tissue-specific expression of isoforms and molecular interactions with BP180/type XVII collagen".
2762:
Sawamura D, Li KH, Nomura K, et al. (1991). "Bullous pemphigoid antigen: cDNA cloning, cellular expression, and evidence for polymorphism of the human gene".
1520:
Thangavelu P, Krenács T, Dray E, Duijf P (2016), "In epithelial cancers, aberrant COL17A1 promoter methylation predicts its misexpression and increased invasion",
2829:
Myers JC, Sun MJ, D'Ippolito JA, et al. (1993). "Human cDNA clones transcribed from an unusually high-molecular-weight RNA encode a new collagen chain".
2066:"A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180"
2389:
Aho S, Uitto J (March 1999). "180-kD bullous pemphigoid antigen/type XVII collagen: tissue-specific expression and molecular interactions with keratin 18".
3427:
90:
759:
740:
3368:
Aho S, Uitto J (1999). "180-kD bullous pemphigoid antigen/type XVII collagen: tissue-specific expression and molecular interactions with keratin 18".
2636:
Schaapveld RQ, Borradori L, Geerts D, van
Leusden M R, Kuikman I, Nievers M G, Niessen C M, Steenbergen R D, Snijders P J, Sonnenberg A (July 1998).
1460:
Bardhan A, Bruckner-Tuderman L, Chapple IL, Fine JD, Harper N, Has C, Magin TM, Marinkovich MP, Marshall JF, McGrath JA, Mellerio JE (2020-09-24).
2930:"Cloning of the human type XVII collagen gene (COL17A1), and detection of novel mutations in generalized atrophic benign epidermolysis bullosa"
4106:
1300:
1220:
1282:
1886:
Zillikens D, Giudice GJ (1999). "BP180/type XVII collagen: its role in acquired and inherited disorders or the dermal-epidermal junction".
1040:
COL17A1 is the official name of the gene. It encodes the alpha chain of type XVII collagen. Collagen XVII is a transmembrane protein, like
1059:. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa, as well as recurrent
254:
4075:
2555:
971:
3381:
2402:
3191:
Aho S, McLean WH, Li K, Uitto J (1998). "cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes".
978:
231:
1566:
1269:
1248:
4085:
3420:
2698:
Giudice GJ, Emery DJ, Diaz LA (1992). "Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180".
153:
128:
2860:"Demonstration of the molecular shape of BP180, a 180-kDa bullous pemphigoid antigen and its potential for trimer formation"
1724:"Demonstration of the molecular shape of BP180, a 180-kDa bullous pemphigoid antigen and its potential for trimer formation"
1582:"Demonstration of the molecular shape of BP180, a 180-kDa bullous pemphigoid antigen and its potential for trimer formation"
1265:
3807:
3711:
3686:
1623:"Interaction of BP180 (type XVII collagen) and alpha 6 integrin is necessary for stabilization of hemidesmosome structure"
1045:
1244:
1130:
3839:
3768:
3701:
1041:
70:
267:
166:
3757:
3716:
3603:
3598:
3593:
3587:
3506:
1184:
1049:
260:
159:
3795:
3731:
3674:
3646:
3636:
3566:
3499:
3784:
3519:
3481:
3413:
1765:"Cleavage of BP180, a 180-kDa bullous pemphigoid antigen, yields a 120-kDa collagenous extracellular polypeptide"
61:, BA16H23.2, BP180, BPA-2, BPAG2, LAD-1, ERED, collagen type XVII alpha 1, collagen type XVII alpha 1 chain, JEB4
3300:"Novel homozygous and compound heterozygous COL17A1 mutations associated with junctional epidermolysis bullosa"
804:
78:
1172:
1129:
Other mutations make the epithelium of the cornea in the eye brittle, which results in dominantly inherited
785:
3335:"Two forms of collagen XVII in keratinocytes. A full-length transmembrane protein and a soluble ectodomain"
1806:"Two forms of collagen XVII in keratinocytes. A full-length transmembrane protein and a soluble ectodomain"
2123:"Mutations in collagen, type XVII, alpha 1 (COL17A1) cause epithelial recurrent erosion dystrophy (ERED)"
3853:
1112:
142:
3448:
2313:"Extracellular phosphorylation of collagen XVII by ecto-casein kinase 2 inhibits ectodomain shedding"
2183:
1847:"Properties of the collagen type XVII ectodomain. Evidence for n- to c-terminal triple helix folding"
1141:, a theory which subsequently was confirmed in several families with ERED from different countries.
57:
3680:
2311:
Zimina EP, Fritsch A, Schermer B, Bakulina AY, Bashkurov M, Benzing T, Bruckner-Tuderman L (2007).
1134:
950:
903:
4111:
4019:
3830:
3393:
2994:
2817:
2575:
2524:
2422:
2152:
1911:
1581:
1497:
1123:
1119:
102:
1964:
Diaz LA, Ratrie H, Saunders WS, Futamura S, Squiquera HL, Anhalt GJ, Giudice GJ (October 1990).
1359:
Diaz LA, Ratrie H, Saunders WS, Futamura S, Squiquera HL, Anhalt GJ, Giudice GJ (October 1990).
1107:
954:
929:
899:
878:
874:
4024:
3834:
3625:
3385:
3356:
3321:
3286:
3251:
3208:
3179:
3150:
3115:
3080:
3037:
2986:
2951:
2916:
2881:
2846:
2809:
2779:
2750:
2715:
2675:
2657:
2618:
2610:
2567:
2559:
2516:
2508:
2472:
2464:
2414:
2406:
2334:
2293:
2252:
2211:
2144:
2103:
2085:
2046:
2038:
2003:
1985:
1946:
1903:
1868:
1827:
1786:
1745:
1704:
1686:
1644:
1603:
1549:
1489:
1481:
1442:
1398:
1380:
1341:
505:
50:
98:
3949:
3944:
3905:
3900:
3895:
3890:
3885:
3630:
3494:
3377:
3346:
3311:
3276:
3241:
3233:
3200:
3171:
3140:
3105:
3070:
3062:
3027:
3019:
2976:
2941:
2906:
2871:
2838:
2801:
2771:
2740:
2707:
2665:
2649:
2602:
2551:
2500:
2456:
2398:
2324:
2283:
2242:
2201:
2191:
2134:
2093:
2077:
2030:
1993:
1977:
1938:
1895:
1858:
1845:
Areida SK, Reinhardt DP, Muller PK, Fietzek PP, Kowitz J, Marinkovich MP, Notbohm H (2001).
1817:
1776:
1735:
1694:
1678:
1634:
1593:
1539:
1529:
1473:
1432:
1388:
1372:
1331:
1200:
347:
278:
222:
177:
4070:
3927:
3922:
3917:
3513:
3475:
1192:
1060:
322:
2231:"Shedding of collagen XVII/BP180: structural motifs influence cleavage from cell surface"
1421:"A COL17A1 Splice-Altering Mutation Is Prevalent in Inherited Recurrent Corneal Erosions"
2187:
3557:
3246:
3221:
3075:
3050:
3032:
3007:
2946:
2929:
2911:
2894:
2670:
2637:
2206:
2171:
1544:
2981:
2964:
2745:
2728:
2098:
2065:
2064:
Liu Z, Diaz LA, Troy JL, Taylor AF, Emery DJ, Fairley JA, Giudice GJ (November 1993).
1998:
1965:
1942:
1393:
1360:
674:
669:
664:
659:
654:
638:
633:
628:
623:
618:
613:
608:
603:
598:
593:
588:
583:
578:
573:
557:
552:
547:
4100:
3858:
3440:
3316:
3299:
3281:
3264:
3145:
3128:
2842:
1699:
1666:
1639:
1622:
1501:
1137:(c.3156C>T) was proposed to introduce a cryptic donor site, resulting in aberrant
1084:
534:
3397:
2998:
2821:
2579:
2528:
2426:
2156:
1915:
1461:
3982:
1804:
Schacke H, Schumann H, Hammami-Hauasli N, Raghunath M, Bruckner-Tuderman L (1998).
1138:
1093:
340:
119:
2272:"Shedding of collagen XVII ectodomain depends on plasma membrane microenvironment"
82:
3110:
3093:
2775:
2711:
2196:
2034:
1437:
1420:
106:
4060:
3989:
3725:
3670:
2965:"Revertant mosaicism in epidermolysis bullosa caused by mitotic gene conversion"
1320:"Collagenous transmembrane proteins: recent insights into biology and pathology"
1305:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1287:
National Center for
Biotechnology Information, U.S. National Library of Medicine
423:
3691:
2444:
1534:
1477:
1188:
1168:
1056:
239:
136:
86:
3351:
3334:
2876:
2859:
2661:
2614:
2563:
2512:
2468:
2410:
2089:
2042:
1989:
1822:
1805:
1740:
1723:
1690:
1598:
1485:
1384:
2460:
1781:
1764:
704:
483:
361:
306:
293:
205:
192:
94:
3389:
3204:
3175:
3023:
2606:
2571:
2556:
10.1002/(SICI)1097-4644(19990601)73:3<390::AID-JCB10>3.0.CO;2-1
2520:
2476:
2418:
2338:
2329:
2312:
2297:
2288:
2271:
2256:
2247:
2230:
2229:
Franzke CW, Tasanen K, Borradori L, Huotari V, Bruckner-Tuderman L (2004).
2215:
2148:
1950:
1907:
1872:
1863:
1846:
1763:
Hirako Y, Usukura J, Uematsu J, Hashimoto T, Kitajima Y, Owaribe K (1998).
1708:
1553:
1493:
1446:
1345:
1336:
1319:
3405:
3382:
10.1002/(SICI)1097-4644(19990301)72:3<356::AID-JCB5>3.0.CO;2-M
3360:
3325:
3290:
3255:
3237:
3212:
3183:
3154:
3119:
3084:
3041:
2990:
2955:
2920:
2885:
2850:
2813:
2783:
2754:
2719:
2679:
2653:
2622:
2403:
10.1002/(SICI)1097-4644(19990301)72:3<356::AID-JCB5>3.0.CO;2-M
2107:
2050:
2007:
1899:
1831:
1790:
1749:
1648:
1607:
1402:
1018:
1013:
3843:
3822:
3459:
1682:
1196:
1076:
1071:
1002:
849:
830:
4065:
4056:
4004:
3977:
3872:
3848:
3812:
3800:
3618:
3613:
3608:
3536:
3436:
2139:
2122:
1088:
1080:
816:
771:
558:
extracellular matrix structural constituent conferring tensile strength
2805:
2504:
2445:"Interactions of a hemidesmosome component and actinin family members"
2081:
1981:
1376:
4009:
3773:
3746:
3741:
3736:
3661:
3656:
3651:
3641:
3576:
3571:
3529:
3524:
3486:
1204:
1053:
986:
726:
17:
2353:
3066:
4034:
4029:
3999:
3994:
3972:
3954:
3932:
3541:
2372:"OMIM Entry - # 616507 - OSTEOGENESIS IMPERFECTA, TYPE XVII; OI17"
1208:
689:
685:
4014:
3049:
Schumann H, Hammami-Hauasli N, Pulkkinen L, et al. (1997).
74:
3409:
2371:
1929:
Zillikens D (1999). "Acquired skin disease of hemidesmosomes".
514:
3333:
Schäcke H, Schumann H, Hammami-Hauasli N, et al. (1998).
1419:
1171:
mutations in collagen XVII, which in turn causes a type of
1083:, and BP230 and is necessary for the stable attachment of
3220:
Schaapveld RQ, Borradori L, Geerts D, et al. (1998).
2443:
Gonzalez AM, Otey C, Edlund M, Jones J C (December 2001).
1159:
phosphorylation negatively regulates ectodomain shedding.
3298:
Floeth M, Fiedorowicz J, Schäcke H, et al. (1998).
330:
3006:
Borradori L, Koch PJ, Niessen CM, et al. (1997).
2121:
Jonsson F, Byström B, Davidson A, et al. (2015).
3263:
Ishiko A, Shimizu H, Masunaga T, et al. (1998).
2963:
Jonkman MF, Scheffer H, Stulp R, et al. (1997).
1118:
Collagen XVII also plays a role as an autoantigen in
495:
2858:
Hirako Y, Usukura J, Nishizawa Y, Owaribe K (1996).
1722:
Hirako Y, Usukura J, Nishizawa Y, Owaribe K (1996).
1621:
Hopkinson SB, Findlay K, Jones JC, Jones JC (1998).
1580:
Hirako Y, Usukura J, Nishizawa Y, Owaribe K (1996).
1318:
Franzke CW, Bruckner P, Bruckner-Tuderman L (2005).
4049:
3965:
3871:
3821:
3550:
3467:
3458:
3447:
3092:Chavanas S, Gache Y, Tadini G, et al. (1997).
2928:Gatalica B, Pulkkinen L, Li K, et al. (1997).
2727:Li KH, Sawamura D, Giudice GJ, et al. (1992).
1567:"Entrez Gene: COL17A1 collagen, type XVII, alpha 1"
943:
922:
892:
867:
2893:McGrath JA, Gatalica B, Li K, et al. (1996).
2270:Zimina EP, Bruckner-Tuderman L, Franzke C (2005).
1261:
1259:
1257:
1240:
1238:
1236:
277:
176:
1515:
1513:
1511:
2438:
2436:
1660:
1658:
1183:Collagen, type XVII, alpha 1 has been shown to
1150:expression was observed for the other cancers.
3127:Darling TN, Yee C, Koh B, et al. (1998).
1266:GRCm38: Ensembl release 89: ENSMUSG00000025064
3421:
1167:The SPARC gene is completely associated with
8:
1245:GRCh38: Ensembl release 89: ENSG00000065618
1105:Mutations in the human collagen XVII gene,
553:extracellular matrix structural constituent
3464:
3455:
3428:
3414:
3406:
700:
530:
318:
217:
114:
3350:
3315:
3280:
3245:
3144:
3109:
3074:
3031:
2980:
2945:
2910:
2875:
2744:
2669:
2328:
2287:
2246:
2205:
2195:
2170:Lin B, Le D, Chem Y, et al. (2016).
2138:
2097:
1997:
1862:
1821:
1780:
1739:
1698:
1638:
1597:
1543:
1533:
1436:
1392:
1335:
1665:Hopkinson SB, Jones J C (January 2000).
1414:
1412:
639:collagen-containing extracellular matrix
1232:
31:
2070:The Journal of Clinical Investigation
1970:The Journal of Clinical Investigation
1221:List of target antigens in pemphigoid
604:integral component of plasma membrane
282:
243:
238:
181:
140:
135:
7:
4076:Cartilage oligomeric matrix protein
1131:recurrent corneal erosion dystrophy
3055:American Journal of Human Genetics
2934:American Journal of Human Genetics
940:
919:
889:
864:
840:
821:
795:
776:
750:
731:
500:
418:
356:
335:
25:
1365:Journal of Clinical Investigation
1163:SPARC and osteogenesis imperfecta
675:extracellular matrix organization
27:Mammalian protein found in humans
3317:10.1046/j.1523-1747.1998.00325.x
3282:10.1046/j.1523-1747.1998.00231.x
3146:10.1046/j.1523-1747.1998.00103.x
1640:10.1046/j.1523-1747.1998.00452.x
504:
266:
259:
253:
230:
165:
158:
152:
127:
1466:Nature Reviews Disease Primers
574:integral component of membrane
515:More reference expression data
484:More reference expression data
404:olfactory zone of nasal mucosa
1:
3164:Biochem. Biophys. Res. Commun
2982:10.1016/S0092-8674(00)81894-2
2746:10.1016/S0021-9258(18)54393-3
2595:Biochem. Biophys. Res. Commun
1943:10.1016/S0923-1811(99)00019-5
670:regulation of immune response
251:
150:
4107:Genes on human chromosome 10
3840:Cartilage associated protein
3111:10.1111/1523-1747.ep12276614
2843:10.1016/0378-1119(93)90126-N
2776:10.1111/1523-1747.ep12475433
2712:10.1111/1523-1747.ep12616580
2197:10.1371/journal.pone.0157418
2035:10.4049/jimmunol.151.10.5742
1438:10.1016/j.ophtha.2015.12.008
614:endoplasmic reticulum lumen
4128:
972:Chr 10: 104.03 – 104.09 Mb
384:mucosa of transverse colon
1535:10.1186/s13148-016-0290-6
1478:10.1038/s41572-020-0210-0
1301:"Mouse PubMed Reference:"
1283:"Human PubMed Reference:"
1017:
1012:
1008:
1001:
985:
966:
947:
926:
915:
896:
871:
860:
847:
843:
828:
824:
815:
802:
798:
783:
779:
770:
757:
753:
738:
734:
725:
710:
703:
699:
683:
533:
529:
512:
503:
494:
481:
430:
421:
368:
359:
329:
321:
317:
300:
287:
250:
229:
220:
216:
199:
186:
149:
126:
117:
113:
68:
65:
55:
48:
43:
39:
34:
3352:10.1074/jbc.273.40.25937
2877:10.1074/jbc.271.23.13739
1823:10.1074/jbc.273.40.25937
1741:10.1074/jbc.271.23.13739
1599:10.1074/jbc.271.23.13739
979:Chr 19: 47.63 – 47.68 Mb
2461:10.1242/jcs.114.23.4197
2358:Genetics Home Reference
1782:10.1074/jbc.273.16.9711
1462:"Epidermolysis bullosa"
1173:osteogenesis imperfecta
3205:10.1006/geno.1997.5188
3176:10.1006/bbrc.1998.8162
3024:10.1083/jcb.136.6.1333
2607:10.1006/bbrc.1998.8162
2330:10.1074/jbc.M701937200
2289:10.1074/jbc.M503751200
2248:10.1074/jbc.M308835200
1864:10.1074/jbc.M008709200
1337:10.1074/jbc.R400034200
655:hemidesmosome assembly
284:19 D1|19 40.07 cM
3854:Procollagen peptidase
3238:10.1083/jcb.142.1.271
2654:10.1083/jcb.142.1.271
2023:Journal of Immunology
1900:10.1007/s004030050392
1113:epidermolysis bullosa
1092:a flexible, rod-like
665:epidermis development
388:minor salivary glands
245:Chromosome 19 (mouse)
143:Chromosome 10 (human)
1683:10.1091/mbc.11.1.277
1033:, previously called
660:cell-matrix adhesion
634:extracellular matrix
579:extracellular region
438:skin of external ear
3304:J. Invest. Dermatol
3269:J. Invest. Dermatol
3133:J. Invest. Dermatol
3098:J. Invest. Dermatol
2764:J. Invest. Dermatol
2700:J. Invest. Dermatol
2455:(Pt 23): 4197–206.
2241:(23): 24521–24529.
2188:2016PLoSO..1157418L
1888:Arch. Dermatol. Res
1816:(40): 25937–25943.
1734:(23): 13739–13745.
1627:J. Invest. Dermatol
1592:(23): 13739–13745.
1135:synonymous mutation
629:extracellular space
446:conjunctival fornix
107:COL17A1 - orthologs
4020:Matrix gla protein
3831:Prolyl hydroxylase
2140:10.1002/humu.22764
1124:herpes gestationis
1120:Bullous pemphigoid
805:ENSMUSG00000025064
648:Biological process
624:cell-cell junction
567:Cellular component
541:Molecular function
4094:
4093:
4045:
4044:
3867:
3866:
3835:Lysyl hydroxylase
3626:basement membrane
2806:10.1038/ng0995-83
2505:10.1242/jcs.00241
2082:10.1172/JCI116856
2029:(10): 5742–5750.
1982:10.1172/JCI114812
1775:(16): 9711–9717.
1377:10.1172/JCI114812
1028:
1027:
1024:
1023:
997:
996:
962:
961:
937:
936:
911:
910:
886:
885:
856:
855:
837:
836:
811:
810:
792:
791:
766:
765:
747:
746:
695:
694:
584:basement membrane
525:
524:
521:
520:
490:
489:
477:
476:
415:
414:
313:
312:
212:
211:
16:(Redirected from
4119:
3465:
3456:
3430:
3423:
3416:
3407:
3401:
3370:J. Cell. Biochem
3364:
3354:
3345:(40): 25937–43.
3329:
3319:
3294:
3284:
3259:
3249:
3216:
3187:
3158:
3148:
3123:
3113:
3088:
3078:
3045:
3035:
3002:
2984:
2959:
2949:
2924:
2914:
2889:
2879:
2870:(23): 13739–45.
2854:
2825:
2787:
2758:
2748:
2723:
2684:
2683:
2673:
2633:
2627:
2626:
2590:
2584:
2583:
2544:J. Cell. Biochem
2539:
2533:
2532:
2499:(Pt 2): 387–99.
2487:
2481:
2480:
2440:
2431:
2430:
2391:J. Cell. Biochem
2386:
2380:
2379:
2368:
2362:
2361:
2349:
2343:
2342:
2332:
2323:(31): 22737–46.
2308:
2302:
2301:
2291:
2282:(40): 34019–24.
2267:
2261:
2260:
2250:
2226:
2220:
2219:
2209:
2199:
2167:
2161:
2160:
2142:
2118:
2112:
2111:
2101:
2076:(5): 2480–2488.
2061:
2055:
2054:
2018:
2012:
2011:
2001:
1976:(4): 1088–1094.
1961:
1955:
1954:
1931:J. Dermatol. Sci
1926:
1920:
1919:
1883:
1877:
1876:
1866:
1857:(2): 1594–1601.
1842:
1836:
1835:
1825:
1801:
1795:
1794:
1784:
1760:
1754:
1753:
1743:
1719:
1713:
1712:
1702:
1662:
1653:
1652:
1642:
1633:(6): 1015–1022.
1618:
1612:
1611:
1601:
1577:
1571:
1570:
1563:
1557:
1556:
1547:
1537:
1522:Clin Epigenetics
1517:
1506:
1505:
1457:
1451:
1450:
1440:
1416:
1407:
1406:
1396:
1371:(4): 1088–1094.
1356:
1350:
1349:
1339:
1330:(6): 4005–4008.
1315:
1309:
1308:
1297:
1291:
1290:
1279:
1273:
1263:
1252:
1242:
1201:Actinin, alpha 1
1061:corneal erosions
1010:
1009:
981:
974:
957:
941:
932:
920:
916:RefSeq (protein)
906:
890:
881:
865:
841:
822:
796:
777:
751:
732:
701:
531:
517:
508:
501:
486:
426:
424:Top expressed in
419:
364:
362:Top expressed in
357:
336:
319:
309:
296:
285:
270:
263:
257:
246:
234:
218:
208:
195:
184:
169:
162:
156:
145:
131:
115:
109:
60:
53:
32:
21:
4127:
4126:
4122:
4121:
4120:
4118:
4117:
4116:
4097:
4096:
4095:
4090:
4041:
3961:
3863:
3817:
3700:transmembrane:
3546:
3450:
3443:
3434:
3404:
3367:
3332:
3297:
3262:
3219:
3190:
3161:
3126:
3091:
3048:
3005:
2962:
2927:
2892:
2857:
2828:
2790:
2761:
2739:(35): 24064–9.
2726:
2697:
2693:
2691:Further reading
2688:
2687:
2635:
2634:
2630:
2592:
2591:
2587:
2541:
2540:
2536:
2489:
2488:
2484:
2442:
2441:
2434:
2388:
2387:
2383:
2370:
2369:
2365:
2351:
2350:
2346:
2310:
2309:
2305:
2269:
2268:
2264:
2228:
2227:
2223:
2182:(6): e0157418.
2169:
2168:
2164:
2120:
2119:
2115:
2063:
2062:
2058:
2020:
2019:
2015:
1963:
1962:
1958:
1928:
1927:
1923:
1885:
1884:
1880:
1844:
1843:
1839:
1803:
1802:
1798:
1762:
1761:
1757:
1721:
1720:
1716:
1671:Mol. Biol. Cell
1664:
1663:
1656:
1620:
1619:
1615:
1579:
1578:
1574:
1565:
1564:
1560:
1519:
1518:
1509:
1459:
1458:
1454:
1418:
1417:
1410:
1358:
1357:
1353:
1317:
1316:
1312:
1299:
1298:
1294:
1281:
1280:
1276:
1264:
1255:
1243:
1234:
1229:
1217:
1193:Actinin alpha 4
1181:
1165:
1156:
1147:
1103:
1069:
1019:View/Edit Mouse
1014:View/Edit Human
977:
970:
967:Location (UCSC)
953:
949:
928:
902:
898:
877:
873:
786:ENSG00000065618
679:
643:
594:plasma membrane
562:
548:protein binding
513:
482:
473:
468:
464:
462:skin of abdomen
460:
456:
452:
448:
444:
440:
436:
422:
411:
406:
402:
398:
394:
390:
386:
382:
378:
374:
372:skin of abdomen
360:
304:
291:
283:
273:
272:
271:
264:
244:
221:Gene location (
203:
190:
182:
172:
171:
170:
163:
141:
118:Gene location (
69:
56:
49:
28:
23:
22:
15:
12:
11:
5:
4125:
4123:
4115:
4114:
4109:
4099:
4098:
4092:
4091:
4089:
4088:
4083:
4079:
4078:
4073:
4068:
4063:
4053:
4051:
4047:
4046:
4043:
4042:
4040:
4039:
4038:
4037:
4032:
4022:
4017:
4012:
4007:
4002:
3997:
3992:
3987:
3986:
3985:
3975:
3969:
3967:
3963:
3962:
3960:
3959:
3958:
3957:
3952:
3947:
3937:
3936:
3935:
3930:
3925:
3920:
3910:
3909:
3908:
3903:
3898:
3893:
3888:
3877:
3875:
3869:
3868:
3865:
3864:
3862:
3861:
3856:
3851:
3846:
3837:
3827:
3825:
3819:
3818:
3816:
3815:
3810:
3805:
3804:
3803:
3798:
3788:
3778:
3777:
3776:
3771:
3761:
3751:
3750:
3749:
3744:
3739:
3734:
3720:
3719:
3714:
3709:
3704:
3697:
3696:
3695:
3694:
3689:
3677:
3667:
3666:
3665:
3664:
3659:
3654:
3649:
3644:
3639:
3622:
3621:
3616:
3611:
3606:
3601:
3596:
3591:
3581:
3580:
3579:
3574:
3569:
3554:
3552:
3548:
3547:
3545:
3544:
3539:
3534:
3533:
3532:
3527:
3522:
3510:
3503:
3491:
3490:
3489:
3484:
3471:
3469:
3468:Fibril forming
3462:
3453:
3449:Extracellular
3445:
3444:
3441:scleroproteins
3435:
3433:
3432:
3425:
3418:
3410:
3403:
3402:
3365:
3330:
3295:
3260:
3217:
3188:
3159:
3124:
3089:
3067:10.1086/515463
3061:(6): 1344–53.
3046:
3018:(6): 1333–47.
3003:
2960:
2925:
2905:(6): 1787–96.
2890:
2855:
2826:
2788:
2759:
2724:
2694:
2692:
2689:
2686:
2685:
2628:
2585:
2534:
2482:
2432:
2381:
2363:
2352:Reference GH.
2344:
2303:
2262:
2221:
2162:
2133:(4): 463–473.
2113:
2056:
2013:
1956:
1937:(2): 134–154.
1921:
1894:(4): 187–194.
1878:
1837:
1796:
1755:
1714:
1654:
1613:
1572:
1558:
1507:
1452:
1431:(4): 709–722.
1408:
1351:
1310:
1292:
1274:
1253:
1231:
1230:
1228:
1225:
1224:
1223:
1216:
1213:
1180:
1177:
1164:
1161:
1155:
1152:
1146:
1143:
1102:
1099:
1085:hemidesmosomes
1068:
1065:
1026:
1025:
1022:
1021:
1016:
1006:
1005:
999:
998:
995:
994:
992:
990:
983:
982:
975:
968:
964:
963:
960:
959:
945:
944:
938:
935:
934:
924:
923:
917:
913:
912:
909:
908:
894:
893:
887:
884:
883:
869:
868:
862:
858:
857:
854:
853:
845:
844:
838:
835:
834:
826:
825:
819:
813:
812:
809:
808:
800:
799:
793:
790:
789:
781:
780:
774:
768:
767:
764:
763:
755:
754:
748:
745:
744:
736:
735:
729:
723:
722:
717:
712:
708:
707:
697:
696:
693:
692:
681:
680:
678:
677:
672:
667:
662:
657:
651:
649:
645:
644:
642:
641:
636:
631:
626:
621:
616:
611:
606:
601:
596:
591:
586:
581:
576:
570:
568:
564:
563:
561:
560:
555:
550:
544:
542:
538:
537:
527:
526:
523:
522:
519:
518:
510:
509:
498:
492:
491:
488:
487:
479:
478:
475:
474:
472:
471:
470:female urethra
467:
463:
459:
455:
451:
447:
443:
439:
435:
434:corneal stroma
431:
428:
427:
416:
413:
412:
410:
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
366:
365:
353:
352:
344:
333:
327:
326:
323:RNA expression
315:
314:
311:
310:
302:
298:
297:
289:
286:
281:
275:
274:
265:
258:
252:
248:
247:
242:
236:
235:
227:
226:
214:
213:
210:
209:
201:
197:
196:
188:
185:
180:
174:
173:
164:
157:
151:
147:
146:
139:
133:
132:
124:
123:
111:
110:
67:
63:
62:
54:
46:
45:
41:
40:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4124:
4113:
4110:
4108:
4105:
4104:
4102:
4087:
4084:
4081:
4080:
4077:
4074:
4072:
4069:
4067:
4064:
4062:
4058:
4055:
4054:
4052:
4048:
4036:
4033:
4031:
4028:
4027:
4026:
4023:
4021:
4018:
4016:
4013:
4011:
4008:
4006:
4003:
4001:
3998:
3996:
3993:
3991:
3988:
3984:
3981:
3980:
3979:
3976:
3974:
3971:
3970:
3968:
3964:
3956:
3953:
3951:
3948:
3946:
3943:
3942:
3941:
3938:
3934:
3931:
3929:
3926:
3924:
3921:
3919:
3916:
3915:
3914:
3911:
3907:
3904:
3902:
3899:
3897:
3894:
3892:
3889:
3887:
3884:
3883:
3882:
3879:
3878:
3876:
3874:
3870:
3860:
3859:Lysyl oxidase
3857:
3855:
3852:
3850:
3847:
3845:
3841:
3838:
3836:
3832:
3829:
3828:
3826:
3824:
3820:
3814:
3811:
3809:
3806:
3802:
3799:
3797:
3794:
3793:
3792:
3789:
3786:
3782:
3779:
3775:
3772:
3770:
3767:
3766:
3765:
3762:
3759:
3755:
3752:
3748:
3745:
3743:
3740:
3738:
3735:
3733:
3730:
3729:
3728:
3727:
3722:
3721:
3718:
3715:
3713:
3710:
3708:
3705:
3703:
3699:
3698:
3693:
3690:
3688:
3685:
3684:
3683:
3682:
3678:
3676:
3672:
3669:
3668:
3663:
3660:
3658:
3655:
3653:
3650:
3648:
3645:
3643:
3640:
3638:
3635:
3634:
3633:
3632:
3627:
3624:
3623:
3620:
3617:
3615:
3612:
3610:
3607:
3605:
3602:
3600:
3597:
3595:
3592:
3589:
3585:
3582:
3578:
3575:
3573:
3570:
3568:
3565:
3564:
3563:
3559:
3556:
3555:
3553:
3549:
3543:
3540:
3538:
3535:
3531:
3528:
3526:
3523:
3521:
3518:
3517:
3516:
3515:
3511:
3509:
3508:
3504:
3501:
3497:
3496:
3492:
3488:
3485:
3483:
3480:
3479:
3478:
3477:
3473:
3472:
3470:
3466:
3463:
3461:
3457:
3454:
3452:
3446:
3442:
3438:
3431:
3426:
3424:
3419:
3417:
3412:
3411:
3408:
3399:
3395:
3391:
3387:
3383:
3379:
3376:(3): 356–67.
3375:
3371:
3366:
3362:
3358:
3353:
3348:
3344:
3340:
3339:J. Biol. Chem
3336:
3331:
3327:
3323:
3318:
3313:
3310:(3): 528–33.
3309:
3305:
3301:
3296:
3292:
3288:
3283:
3278:
3274:
3270:
3266:
3261:
3257:
3253:
3248:
3243:
3239:
3235:
3232:(1): 271–84.
3231:
3227:
3223:
3218:
3214:
3210:
3206:
3202:
3198:
3194:
3189:
3185:
3181:
3177:
3173:
3169:
3165:
3160:
3156:
3152:
3147:
3142:
3138:
3134:
3130:
3125:
3121:
3117:
3112:
3107:
3103:
3099:
3095:
3090:
3086:
3082:
3077:
3072:
3068:
3064:
3060:
3056:
3052:
3047:
3043:
3039:
3034:
3029:
3025:
3021:
3017:
3013:
3009:
3004:
3000:
2996:
2992:
2988:
2983:
2978:
2975:(4): 543–51.
2974:
2970:
2966:
2961:
2957:
2953:
2948:
2943:
2940:(2): 352–65.
2939:
2935:
2931:
2926:
2922:
2918:
2913:
2908:
2904:
2900:
2899:Am. J. Pathol
2896:
2891:
2887:
2883:
2878:
2873:
2869:
2865:
2864:J. Biol. Chem
2861:
2856:
2852:
2848:
2844:
2840:
2836:
2832:
2827:
2823:
2819:
2815:
2811:
2807:
2803:
2799:
2795:
2789:
2785:
2781:
2777:
2773:
2770:(6): 908–15.
2769:
2765:
2760:
2756:
2752:
2747:
2742:
2738:
2734:
2733:J. Biol. Chem
2730:
2725:
2721:
2717:
2713:
2709:
2706:(3): 243–50.
2705:
2701:
2696:
2695:
2690:
2681:
2677:
2672:
2667:
2663:
2659:
2655:
2651:
2648:(1): 271–84.
2647:
2643:
2639:
2632:
2629:
2624:
2620:
2616:
2612:
2608:
2604:
2600:
2596:
2589:
2586:
2581:
2577:
2573:
2569:
2565:
2561:
2557:
2553:
2549:
2545:
2538:
2535:
2530:
2526:
2522:
2518:
2514:
2510:
2506:
2502:
2498:
2494:
2486:
2483:
2478:
2474:
2470:
2466:
2462:
2458:
2454:
2450:
2446:
2439:
2437:
2433:
2428:
2424:
2420:
2416:
2412:
2408:
2404:
2400:
2397:(3): 356–67.
2396:
2392:
2385:
2382:
2377:
2373:
2367:
2364:
2359:
2355:
2348:
2345:
2340:
2336:
2331:
2326:
2322:
2318:
2314:
2307:
2304:
2299:
2295:
2290:
2285:
2281:
2277:
2273:
2266:
2263:
2258:
2254:
2249:
2244:
2240:
2236:
2235:J. Biol. Chem
2232:
2225:
2222:
2217:
2213:
2208:
2203:
2198:
2193:
2189:
2185:
2181:
2177:
2173:
2166:
2163:
2158:
2154:
2150:
2146:
2141:
2136:
2132:
2128:
2124:
2117:
2114:
2109:
2105:
2100:
2095:
2091:
2087:
2083:
2079:
2075:
2071:
2067:
2060:
2057:
2052:
2048:
2044:
2040:
2036:
2032:
2028:
2024:
2017:
2014:
2009:
2005:
2000:
1995:
1991:
1987:
1983:
1979:
1975:
1971:
1967:
1960:
1957:
1952:
1948:
1944:
1940:
1936:
1932:
1925:
1922:
1917:
1913:
1909:
1905:
1901:
1897:
1893:
1889:
1882:
1879:
1874:
1870:
1865:
1860:
1856:
1852:
1851:J. Biol. Chem
1848:
1841:
1838:
1833:
1829:
1824:
1819:
1815:
1811:
1810:J. Biol. Chem
1807:
1800:
1797:
1792:
1788:
1783:
1778:
1774:
1770:
1769:J. Biol. Chem
1766:
1759:
1756:
1751:
1747:
1742:
1737:
1733:
1729:
1728:J. Biol. Chem
1725:
1718:
1715:
1710:
1706:
1701:
1696:
1692:
1688:
1684:
1680:
1677:(1): 277–86.
1676:
1672:
1668:
1661:
1659:
1655:
1650:
1646:
1641:
1636:
1632:
1628:
1624:
1617:
1614:
1609:
1605:
1600:
1595:
1591:
1587:
1586:J. Biol. Chem
1583:
1576:
1573:
1568:
1562:
1559:
1555:
1551:
1546:
1541:
1536:
1531:
1527:
1523:
1516:
1514:
1512:
1508:
1503:
1499:
1495:
1491:
1487:
1483:
1479:
1475:
1471:
1467:
1463:
1456:
1453:
1448:
1444:
1439:
1434:
1430:
1426:
1425:Ophthalmology
1422:
1415:
1413:
1409:
1404:
1400:
1395:
1390:
1386:
1382:
1378:
1374:
1370:
1366:
1362:
1355:
1352:
1347:
1343:
1338:
1333:
1329:
1325:
1324:J. Biol. Chem
1321:
1314:
1311:
1306:
1302:
1296:
1293:
1288:
1284:
1278:
1275:
1271:
1267:
1262:
1260:
1258:
1254:
1250:
1246:
1241:
1239:
1237:
1233:
1226:
1222:
1219:
1218:
1214:
1212:
1210:
1206:
1202:
1198:
1194:
1190:
1186:
1178:
1176:
1174:
1170:
1162:
1160:
1153:
1151:
1144:
1142:
1140:
1136:
1132:
1127:
1125:
1121:
1116:
1114:
1110:
1109:
1100:
1098:
1095:
1090:
1086:
1082:
1078:
1073:
1066:
1064:
1062:
1058:
1055:
1051:
1047:
1043:
1042:collagen XIII
1038:
1036:
1032:
1031:Collagen XVII
1020:
1015:
1011:
1007:
1004:
1000:
993:
991:
988:
984:
980:
976:
973:
969:
965:
958:
956:
952:
946:
942:
939:
933:
931:
925:
921:
918:
914:
907:
905:
901:
895:
891:
888:
882:
880:
876:
870:
866:
863:
861:RefSeq (mRNA)
859:
852:
851:
846:
842:
839:
833:
832:
827:
823:
820:
818:
814:
807:
806:
801:
797:
794:
788:
787:
782:
778:
775:
773:
769:
762:
761:
756:
752:
749:
743:
742:
737:
733:
730:
728:
724:
721:
718:
716:
713:
709:
706:
702:
698:
691:
687:
682:
676:
673:
671:
668:
666:
663:
661:
658:
656:
653:
652:
650:
647:
646:
640:
637:
635:
632:
630:
627:
625:
622:
620:
617:
615:
612:
610:
609:hemidesmosome
607:
605:
602:
600:
597:
595:
592:
590:
589:cell junction
587:
585:
582:
580:
577:
575:
572:
571:
569:
566:
565:
559:
556:
554:
551:
549:
546:
545:
543:
540:
539:
536:
535:Gene ontology
532:
528:
516:
511:
507:
502:
499:
497:
493:
485:
480:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
432:
429:
425:
420:
417:
407:
403:
399:
396:skin of thigh
395:
391:
387:
383:
379:
375:
371:
370:
367:
363:
358:
355:
354:
351:
349:
345:
343:
342:
338:
337:
334:
332:
328:
324:
320:
316:
308:
303:
299:
295:
290:
280:
276:
269:
262:
256:
249:
241:
237:
233:
228:
224:
219:
215:
207:
202:
198:
194:
189:
179:
175:
168:
161:
155:
148:
144:
138:
134:
130:
125:
121:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
72:
64:
59:
52:
47:
42:
38:
33:
30:
19:
3983:Tropoelastin
3939:
3912:
3880:
3790:
3780:
3763:
3753:
3724:
3706:
3679:
3629:
3583:
3561:
3512:
3505:
3493:
3474:
3373:
3369:
3342:
3338:
3307:
3303:
3272:
3268:
3229:
3226:J. Cell Biol
3225:
3199:(2): 242–7.
3196:
3192:
3170:(3): 694–9.
3167:
3163:
3139:(2): 165–9.
3136:
3132:
3101:
3097:
3058:
3054:
3015:
3012:J. Cell Biol
3011:
2972:
2968:
2937:
2933:
2902:
2898:
2867:
2863:
2837:(2): 211–7.
2834:
2830:
2797:
2793:
2767:
2763:
2736:
2732:
2703:
2699:
2645:
2642:J. Cell Biol
2641:
2631:
2601:(3): 694–9.
2598:
2594:
2588:
2550:(3): 390–9.
2547:
2543:
2537:
2496:
2492:
2485:
2452:
2448:
2394:
2390:
2384:
2375:
2366:
2357:
2354:"SPARC gene"
2347:
2320:
2316:
2306:
2279:
2275:
2265:
2238:
2234:
2224:
2179:
2175:
2165:
2130:
2126:
2116:
2073:
2069:
2059:
2026:
2022:
2016:
1973:
1969:
1959:
1934:
1930:
1924:
1891:
1887:
1881:
1854:
1850:
1840:
1813:
1809:
1799:
1772:
1768:
1758:
1731:
1727:
1717:
1674:
1670:
1630:
1626:
1616:
1589:
1585:
1575:
1561:
1525:
1521:
1469:
1465:
1455:
1428:
1424:
1368:
1364:
1354:
1327:
1323:
1313:
1304:
1295:
1286:
1277:
1182:
1179:Interactions
1166:
1157:
1148:
1128:
1117:
1106:
1104:
1094:triple helix
1070:
1039:
1034:
1030:
1029:
951:NP_001277754
948:
927:
904:NM_001290825
897:
872:
848:
829:
803:
784:
758:
739:
719:
714:
454:skin of back
408:right testis
346:
339:
204:104,085,880
191:104,031,286
66:External IDs
29:
4061:Cytokeratin
3990:Vitronectin
3671:multiplexin
3275:(1): 93–6.
3104:(1): 74–8.
2800:(1): 83–6.
2493:J. Cell Sci
2449:J. Cell Sci
2317:J Biol Chem
2276:J Biol Chem
400:skin of hip
380:skin of arm
376:skin of leg
305:47,680,533
292:47,634,783
44:Identifiers
4101:Categories
3692:Endostatin
3681:type XVIII
2794:Nat. Genet
2127:Hum. Mutat
1272:, May 2017
1251:, May 2017
1227:References
1189:Keratin 18
1169:homozygous
1057:epithelium
350:(ortholog)
87:HomoloGene
4112:Collagens
4071:Reticulin
3764:type VIII
2662:0021-9525
2615:0006-291X
2564:0730-2312
2513:0021-9533
2469:0021-9533
2411:0730-2312
2090:0021-9738
2043:0022-1767
1990:0021-9738
1691:1059-1524
1502:221861310
1486:2056-676X
1472:(1): 78.
1385:0021-9738
1122:(BP) and
1101:Pathology
1067:Structure
955:NP_031758
930:NP_000485
900:NM_007732
879:NM_000494
875:NM_130778
705:Orthologs
466:epidermis
458:esophagus
95:GeneCards
4086:diseases
4082:See also
4025:Tectorin
3844:Leprecan
3754:type VII
3584:type XII
3507:type III
3460:Collagen
3398:30404639
3390:10022517
3193:Genomics
2999:18970859
2822:23732185
2580:43899550
2572:10321838
2529:16745491
2521:12482924
2477:11739652
2427:30404639
2419:10022517
2376:omim.org
2339:17545155
2298:16020548
2257:15047704
2216:27309958
2176:PLOS ONE
2157:13562400
2149:25676728
1951:10379705
1916:27592712
1908:10335914
1873:11042218
1709:10637308
1554:27891193
1494:32973163
1447:26786512
1346:15561712
1268:–
1247:–
1215:See also
1197:Dystonin
1185:interact
1154:Shedding
1139:splicing
1077:integrin
1072:Collagen
1003:Wikidata
684:Sources:
619:membrane
599:collagen
4066:Gelatin
4057:Keratin
4005:Decorin
3978:Elastin
3873:Laminin
3849:ADAMTS2
3823:Enzymes
3813:COL28A1
3808:COL27A1
3801:COL11A2
3796:COL11A1
3791:type XI
3785:COL10A1
3726:type VI
3723:other:
3717:COL25A1
3712:COL23A1
3707:COL17A1
3702:COL13A1
3687:COL18A1
3675:COL15A1
3631:type IV
3619:COL22A1
3614:COL21A1
3609:COL20A1
3604:COL19A1
3599:COL16A1
3594:COL14A1
3588:COL12A1
3562:type IX
3542:COL26A1
3537:COL24A1
3495:type II
3437:Protein
3361:9748270
3326:9740252
3291:9665393
3256:9660880
3247:2133016
3213:9521878
3184:9500991
3155:9457913
3120:9204958
3085:9199555
3076:1716115
3042:9087447
3033:2132520
2991:9038345
2956:9012408
2947:1712405
2921:8669466
2912:1861650
2886:8662839
2851:7916703
2814:7550320
2784:2045679
2755:1748679
2720:1324962
2680:9660880
2671:2133016
2623:9500991
2207:4911149
2184:Bibcode
2108:7693763
2051:8228259
2008:1698819
1832:9748270
1791:9545306
1750:8662839
1649:9856810
1608:8662839
1545:5116176
1528:: 120,
1403:1698819
1270:Ensembl
1249:Ensembl
1108:COL17A1
1089:keratin
1081:plectin
1054:corneal
817:UniProt
772:Ensembl
711:Species
690:QuickGO
325:pattern
183:10q25.1
99:COL17A1
58:COL17A1
51:Aliases
35:COL17A1
4010:FAM20C
3781:type X
3774:COL8A2
3769:COL8A1
3758:COL7A1
3747:COL6A5
3742:COL6A3
3737:COL6A2
3732:COL6A1
3662:COL4A6
3657:COL4A5
3652:COL4A4
3647:COL4A3
3642:COL4A2
3637:COL4A1
3577:COL9A3
3572:COL9A2
3567:COL9A1
3530:COL5A3
3525:COL5A2
3520:COL5A1
3514:type V
3500:COL2A1
3487:COL1A2
3482:COL1A1
3476:type I
3451:matrix
3396:
3388:
3359:
3324:
3289:
3254:
3244:
3211:
3182:
3153:
3118:
3083:
3073:
3040:
3030:
2997:
2989:
2954:
2944:
2919:
2909:
2884:
2849:
2820:
2812:
2782:
2753:
2718:
2678:
2668:
2660:
2621:
2613:
2578:
2570:
2562:
2527:
2519:
2511:
2475:
2467:
2425:
2417:
2409:
2337:
2296:
2255:
2214:
2204:
2155:
2147:
2106:
2099:288433
2096:
2088:
2049:
2041:
2006:
1999:296836
1996:
1988:
1949:
1914:
1906:
1871:
1830:
1789:
1748:
1707:
1697:
1689:
1647:
1606:
1552:
1542:
1500:
1492:
1484:
1445:
1401:
1394:296836
1391:
1383:
1344:
1205:CTNND1
1145:Cancer
1075:beta4-
989:search
987:PubMed
850:Q07563
831:Q9UMD9
727:Entrez
496:BioGPS
392:rectum
91:133558
75:113811
4050:Other
4035:TECTB
4030:TECTA
4000:FREM2
3995:FRAS1
3973:ALCAM
3966:Other
3955:LAMC3
3950:LAMC2
3945:LAMC1
3940:gamma
3933:LAMB4
3928:LAMB3
3923:LAMB2
3918:LAMB1
3906:LAMA5
3901:LAMA4
3896:LAMA3
3891:LAMA2
3886:LAMA1
3881:alpha
3558:FACIT
3551:Other
3394:S2CID
2995:S2CID
2818:S2CID
2576:S2CID
2525:S2CID
2423:S2CID
2153:S2CID
1912:S2CID
1700:14774
1498:S2CID
1209:ITGB4
1187:with
1046:XXIII
1035:BP180
760:12821
720:Mouse
715:Human
686:Amigo
450:molar
348:Mouse
341:Human
288:Start
223:Mouse
187:Start
120:Human
83:88450
18:BPAG2
4015:ECM1
3913:beta
3386:PMID
3357:PMID
3322:PMID
3287:PMID
3252:PMID
3209:PMID
3180:PMID
3151:PMID
3116:PMID
3081:PMID
3038:PMID
2987:PMID
2969:Cell
2952:PMID
2917:PMID
2882:PMID
2847:PMID
2831:Gene
2810:PMID
2780:PMID
2751:PMID
2716:PMID
2676:PMID
2658:ISSN
2619:PMID
2611:ISSN
2568:PMID
2560:ISSN
2517:PMID
2509:ISSN
2473:PMID
2465:ISSN
2415:PMID
2407:ISSN
2335:PMID
2294:PMID
2253:PMID
2212:PMID
2145:PMID
2104:PMID
2086:ISSN
2047:PMID
2039:ISSN
2004:PMID
1986:ISSN
1947:PMID
1904:PMID
1869:PMID
1828:PMID
1787:PMID
1746:PMID
1705:PMID
1687:ISSN
1645:PMID
1604:PMID
1550:PMID
1490:PMID
1482:ISSN
1443:PMID
1399:PMID
1381:ISSN
1342:PMID
1207:and
1048:and
741:1308
331:Bgee
279:Band
240:Chr.
178:Band
137:Chr.
71:OMIM
3378:doi
3347:doi
3343:273
3312:doi
3308:111
3277:doi
3273:111
3242:PMC
3234:doi
3230:142
3201:doi
3172:doi
3168:243
3141:doi
3137:110
3106:doi
3102:109
3071:PMC
3063:doi
3028:PMC
3020:doi
3016:136
2977:doi
2942:PMC
2907:PMC
2903:148
2872:doi
2868:271
2839:doi
2835:123
2802:doi
2772:doi
2741:doi
2737:266
2708:doi
2666:PMC
2650:doi
2646:142
2603:doi
2599:243
2552:doi
2501:doi
2497:116
2457:doi
2453:114
2399:doi
2325:doi
2321:282
2284:doi
2280:280
2243:doi
2239:279
2202:PMC
2192:doi
2135:doi
2094:PMC
2078:doi
2031:doi
2027:151
1994:PMC
1978:doi
1939:doi
1896:doi
1892:291
1859:doi
1855:276
1818:doi
1814:273
1777:doi
1773:273
1736:doi
1732:271
1695:PMC
1679:doi
1635:doi
1631:111
1594:doi
1590:271
1540:PMC
1530:doi
1474:doi
1433:doi
1429:123
1389:PMC
1373:doi
1332:doi
1328:280
1087:to
1050:XXV
442:lip
301:End
200:End
103:OMA
79:MGI
4103::
3673::
3628::
3560::
3439::
3392:.
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