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Lymphoid leukemia

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Reimer P, Schertlin T, Rüdiger T, Geissinger E, Roth S, Kunzmann V, Weissinger F, Nerl C, Schmitz N, Müller-Hermelink HK, Wilhelm M (2004). "Myeloablative radiochemotherapy followed by autologous peripheral blood stem cell transplantation as first-line therapy in peripheral T-cell lymphomas: first
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NK cells are known for their ability to eradicate tumor cells without any prior sensitization to them. One problem when using NK cells in order to fight off lymphoid leukemia is the fact that it is hard to amount enough of them to be effective. One can receive donations of NK cells from parents or
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of the cancer when treatment is initiated, and on a composite of numerous risk factors. The median time from diagnosis to death is less than 1 year in patients overall. Patients diagnosed early and/or with fewer risk factors can sometimes enter complete remission and expect much longer survival.
364:(ANKL) is a lymphoid leukemia that is a deficiency NK cells. Not very much is known about this disease due to its rarity, but it is highly aggressive. A majority of patients with NK cell leukemia die within a year of diagnosis, and for ANKL in particular, half of patients die within two months. 466:
Natural killer (NK) cell therapy is used in pediatrics for children with relapsed lymphoid leukemia. These patients normally have a resistance to chemotherapy, therefore, in order to continue on, must receive some kind of therapy. In some cases, NK cell therapy is a choice.
397:. The TCR gene transcripts are normally positive for ANKL. Current Research is attempting to find the causation of ANKL. So far, the researchers have concluded that lineage of the T-cell receptor gene does not predict the behavior of the disease. 1069: 1054: 443:
is a diagnostic tool in order to count/visualize the amount of lymphatic cells in the body. T cells, B cells and NK cells are nearly impossible to distinguish under a microscope, therefore one must use a flow cytometer to distinguish them.
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Several molecular tumor profiling protocols have been initiated in Europe (e.g., MOSCATO-01, iTHER, and ESMART) to identify actionable lesions for targeted treatment in specific subgroups of patients.
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However, the influential WHO Classification (published in 2001) emphasized a greater emphasis on cell lineage. To this end, lymphoid leukemias can also be divided by the type of cells affected:
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Mercadal S, Briones J, Xicoy B, Pedro C, Escoda L, Estany C, Camós M, Colomo L, Espinosa I, Martínez S, Ribera JM, Martino R, Gutiérrez-García G, Montserrat E, López-Guillermo A (May 2008).
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Suzuki R, Suzumiya J, Yamaguchi M, Nakamura S, Kameoka J, Kojima H, Abe M, Kinoshita T, Yoshino T, Iwatsuki K, Kagami Y, Tsuzuki T, Kurokawa M, Ito K, Kawa K, Oshimi K (May 2010).
1440: 681:"Nasal-type NK/T-cell lymphomas are more frequently T rather than NK lineage based on T-cell receptor gene, RNA, and protein studies: lineage does not predict clinical behavior" 2030: 1000:
Ogbomo, Henry; Cinatl, Jindrich; Mody, Christopher H.; Forsyth, Peter A. (2011). "Immunotherapy in gliomas: Limitations and potential of natural killer (NK) cell therapy".
1839: 722:"Intensive chemotherapy (high-dose CHOP/ESHAP regimen) followed by autologous stem-cell transplantation in previously untreated patients with peripheral T-cell lymphoma" 2053: 1405: 1795: 1134: 900:
Sakamoto, N; Ishikawa, T; Kokura, S; Okayama, T; Oka, K; Ideno, M; Sakai, F; Kato, A; Tanabe, M; Enoki, T; Mineno, J; Naito, Y; Itoh, Y; Yoshikawa, T (2015).
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Historically, they have been most commonly divided by the stage of maturation at which the clonal (neoplastic) lymphoid population stopped maturing:
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relatives through bone marrow transplants. There are also the issues of cost, purity and safety. Unfortunately, there is always the possibility of
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Occurs in older adults. Usually involves lymph nodes, bone marrow and spleen. Most patients have peripheral blood involvement. Indolent.
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of the lymphocytes, to the point that some of them are unitary disease entities that can be called by either name (for example,
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Rubnitz JE, Inaba H, Kang G, Gan K, Hartford C, Triplett BM, Dallas M, Shook D, Gruber T, Pui CH, Leung W (August 2015).
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Landay AL, Muirhead KA (July 1989). "Procedural guidelines for performing immunophenotyping by flow cytometry".
1906: 1734: 1084: 162: 1372: 298:. It causes 15% of acute leukemias in childhood, and also 40% of lymphomas in childhood. It is most common in 1923: 1474: 233:
with irregular nuclear contours, condensed chromatin, small nucleoli and scant cytoplasm without granules.
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Small resting lymphocytes mixed with variable number of large activated cells. Lymph nodes are diffusely
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T-cell leukemia describes several different types of lymphoid leukemias which affect
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B-cell leukemia describes several different types of lymphoid leukemia which affect
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Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson (2007).
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Oshimi K (July 2003). "Leukemia and lymphoma of natural killer lineage cells".
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NK cell therapy is a possible treatment for many different cancers such as
90:. Most lymphoid leukemias involve a particular subtype of lymphocytes, the 665: 2058: 1886: 1597: 1160: 1147: 417:
are commonly offered as the initial therapy. Some patients may receive a
79: 67: 51: 1046: 614: 865: 799:"T-cell Acute Lymphoblastic Leukemia: A Roadmap to Targeted Therapies" 1606: 1058: 393:(TCR) is an important factor when ANKL is being diagnosed along with 323: 319: 288: 150: 91: 1429: 1294: 1278: 255: 187: 1100: 1892: 1786: 1765: 1683: 1425: 1400: 1380: 1376: 1263: 1181: 1176: 850:"Natural killer cell therapy in children with relapsed leukemia" 349:
In practice, it can be hard to distinguish T-cell leukemia from
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Hong M, Lee T, Young Kang S, Kim SJ, Kim W, Ko YH (May 2016).
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Non-mycosis fungoides CD30− cutaneous large T-cell lymphoma
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30% of all leukemias. Also 3 to 4% of lymphomas in adults
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The requirements for diagnosing ANKL are as follows:
1036: 2046: 2011: 1969: 1951: 1915: 1885: 1858: 1813: 1758: 1712: 1703: 1643: 1605: 1596: 1544: 1454: 1415: 1371: 1293: 1262: 1224: 1203: 1192: 1159: 1040: 78:. The lymphocytic leukemias are closely related to 45: 37: 32: 1840:Peripheral T-cell lymphoma not otherwise specified 41:Lymphocytic, lymphogenous, lymphoblastic leukemias 1662:Precursor T acute lymphoblastic leukemia/lymphoma 1216:Precursor B acute lymphoblastic leukemia/lymphoma 951:Bachanova, Veronika; Miller, Jeffrey S. (2014). 1406:Nodular lymphocyte predominant Hodgkin lymphoma 555: 553: 525: 523: 521: 519: 517: 515: 302:males. Its morphology is identical to that of 1796:Secondary cutaneous CD30+ large-cell lymphoma 1128: 762:results of a prospective multicenter study". 513: 511: 509: 507: 505: 503: 501: 499: 497: 495: 137:The most common type of lymphoid leukemia is 8: 1486:Post-transplant lymphoproliferative disorder 1441:immunoproliferative immunoglobulin disorders 1999:Diffuse infiltrative lymphocytosis syndrome 382:Germline configuration genes: TCR-β and IgH 2038:Jessner lymphocytic infiltrate of the skin 1709: 1640: 1602: 1584:Primary cutaneous follicle center lymphoma 1329:Primary cutaneous follicle center lymphoma 1200: 1189: 1156: 1135: 1121: 1113: 1037: 159:Comparison of most common B-cell leukemias 29: 976: 927: 917: 873: 824: 814: 737: 696: 577: 1564:Primary cutaneous marginal zone lymphoma 1362:Primary cutaneous marginal zone lymphoma 155: 2026:with bandlike and perivascular patterns 1988:Autoimmune lymphoproliferative syndrome 895: 893: 491: 353:, and they are often grouped together. 304:precursor B-cell lymphoblastic leukemia 296:precursor T-cell lymphoblastic leukemia 217:Precursor B-cell lymphoblastic leukemia 1835:Enteropathy-associated T-cell lymphoma 797:Cordo V, Meijerink J (January 2021). 7: 1983:X-linked lymphoproliferative disease 227:in childhood, Less common in adults 1939:Large granular lymphocytic leukemia 1559:Intravascular large B-cell lymphoma 334:Large granular lymphocytic leukemia 294:The most common T-cell leukemia is 183:B-cell chronic lymphocytic leukemia 139:B-cell chronic lymphocytic leukemia 405:ANKL is treated similarly to most 25: 906:Journal of Translational Medicine 475:while transplanting bone marrow. 1791:CD30+ cutaneous T-cell lymphoma 969:10.1615/CritRevOncog.2014011091 957:Critical Reviews in Oncogenesis 953:"NK Cells in Therapy of Cancer" 322:. It is highly associated with 2021:Cutaneous lymphoid hyperplasia 2013:Cutaneous lymphoid hyperplasia 1872:Adult T-cell leukemia/lymphoma 1750:Adult T-cell leukemia/lymphoma 1689:Anaplastic large-cell lymphoma 1569:Primary cutaneous immunocytoma 1510:Splenic marginal zone lymphoma 344:T-cell prolymphocytic leukemia 339:Adult T-cell leukemia/lymphoma 318:because of involvement of the 271:B-cell prolymphocytic leukemia 84:adult T-cell leukemia/lymphoma 1: 2069:Lymphoproliferative disorders 1979:Lymphoproliferative disorders 1929:Extranodal NK-T-cell lymphoma 1801:Lymphomatoid papulosis type A 1780:Lymphomatoid papulosis type B 1694:Lymphomatoid papulosis type A 1554:Diffuse large B-cell lymphoma 816:10.1158/2643-3230.BCD-20-0093 88:lymphoproliferative disorders 1961:Acute biphenotypic leukaemia 1850:Subcutaneous T-cell lymphoma 1014:10.1016/j.molmed.2011.03.004 1002:Trends in Molecular Medicine 658:10.1016/0090-1229(89)90192-x 306:. Cell markers include TdT, 264:Acute lymphoblastic leukemia 112:Chronic lymphocytic leukemia 107:Acute lymphoblastic leukemia 1902:Aggressive NK-cell leukemia 1775:Pleomorphic T-cell lymphoma 1481:Lymphomatoid granulomatosis 646:Clin. Immunol. Immunopathol 362:Aggressive NK-cell leukemia 2116: 535:. Philadelphia: Saunders. 254:Other types include (with 1155: 919:10.1186/s12967-015-0632-8 698:10.1038/modpathol.2016.47 376:Immature-looking NK cells 314:. It often presents as a 86:). Such diseases are all 2054:Hematological malignancy 1907:Blastic NK cell lymphoma 1735:Granulomatous slack skin 1491:Classic Hodgkin lymphoma 1390:Classic Hodgkin lymphoma 379:Certain immunophenotypes 533:Robbins Basic Pathology 385:Restricted cytotoxicity 220:(ICD-O: 9835/3-9836/3) 803:Blood Cancer Discovery 776:10.1038/sj.thj.6200359 70:affecting circulating 1933:Angiocentric lymphoma 1523:AIDS-related lymphoma 1347:Splenic marginal zone 739:10.1093/annonc/mdn022 579:10.1093/annonc/mdp418 473:Graft vs host disease 415:chemotherapy regimens 329:Other types include: 2100:Lymphocytic leukemia 2031:with nodular pattern 1730:Pagetoid reticulosis 1342:marginal zone B-cell 854:Pediatr Blood Cancer 419:stem cell transplant 266:, mature B-cell type 245:Usually presents as 1530:Helicobacter pylori 1357:Nodal marginal zone 1284:Hairy cell leukemia 1150:and related disease 277:Hairy cell leukemia 2074:Lymphoid leukemias 1994:Leukemoid reaction 1830:Angioimmunoblastic 1496:Burkitt's lymphoma 615:10.1007/bf02983235 64:Lymphoid leukemias 2082: 2081: 2007: 2006: 1947: 1946: 1881: 1880: 1809: 1808: 1725:Mycosis fungoides 1592: 1591: 1450: 1449: 1394:Nodular sclerosis 1309:follicular B cell 1110: 1109: 866:10.1002/pbc.25555 542:978-1-4160-2973-1 252: 251: 61: 60: 33:Lymphoid leukemia 27:Medical condition 16:(Redirected from 2107: 1844:Lennert lymphoma 1710: 1641: 1603: 1468:Primary effusion 1201: 1190: 1157: 1137: 1130: 1123: 1114: 1038: 1026: 1025: 997: 991: 990: 980: 948: 942: 941: 931: 921: 897: 888: 887: 877: 845: 839: 838: 828: 818: 794: 788: 787: 758: 752: 751: 741: 717: 711: 710: 700: 676: 670: 669: 641: 635: 634: 598: 592: 591: 581: 557: 548: 546: 527: 480:Malignant glioma 453:Targeted therapy 425:Overall survival 407:B-cell lymphomas 357:NK cell leukemia 316:mediastinal mass 283:T-cell leukemias 156: 145:B-cell leukemias 132:NK-cell leukemia 76:white blood cell 30: 21: 2115: 2114: 2110: 2109: 2108: 2106: 2105: 2104: 2085: 2084: 2083: 2078: 2042: 2003: 1965: 1953: 1943: 1911: 1890: 1877: 1854: 1815: 1805: 1754: 1699: 1647: 1645: 1620: 1615: 1609: 1588: 1540: 1446: 1423: 1411: 1367: 1305:germinal center 1289: 1258: 1220: 1196: 1194: 1174: 1169: 1163: 1151: 1141: 1111: 1106: 1105: 1049: 1035: 1030: 1029: 999: 998: 994: 963:(1–2): 133–41. 950: 949: 945: 899: 898: 891: 847: 846: 842: 796: 795: 791: 760: 759: 755: 719: 718: 714: 678: 677: 673: 643: 642: 638: 603:Int. J. Hematol 600: 599: 595: 559: 558: 551: 543: 530: 529:Table 12-8 in: 528: 493: 488: 464: 462:NK cell therapy 455: 450: 438: 427:depends on the 403: 395:T-cell leukemia 391:T-cell receptor 370: 359: 351:T-cell lymphoma 285: 225:acute leukemias 219: 185: 147: 127:T-cell leukemia 122:B-cell leukemia 100: 66:are a group of 28: 23: 22: 18:B cell leukemia 15: 12: 11: 5: 2113: 2111: 2103: 2102: 2097: 2087: 2086: 2080: 2079: 2077: 2076: 2071: 2066: 2064:Leukemia cutis 2061: 2056: 2050: 2048: 2044: 2043: 2041: 2040: 2035: 2034: 2033: 2028: 2017: 2015: 2009: 2008: 2005: 2004: 2002: 2001: 1996: 1991: 1985: 1975: 1973: 1967: 1966: 1964: 1963: 1957: 1955: 1949: 1948: 1945: 1944: 1942: 1941: 1936: 1919: 1917: 1913: 1912: 1910: 1909: 1904: 1898: 1896: 1883: 1882: 1879: 1878: 1876: 1875: 1862: 1860: 1856: 1855: 1853: 1852: 1847: 1837: 1832: 1827: 1821: 1819: 1811: 1810: 1807: 1806: 1804: 1803: 1798: 1793: 1783: 1782: 1777: 1772: 1762: 1760: 1756: 1755: 1753: 1752: 1744:Sézary disease 1738: 1737: 1732: 1727: 1718: 1716: 1707: 1701: 1700: 1698: 1697: 1691: 1679: 1678: 1675:Prolymphocytic 1665: 1651: 1649: 1638: 1637: 1636: 1630: 1600: 1594: 1593: 1590: 1589: 1587: 1586: 1581: 1576: 1571: 1566: 1561: 1556: 1550: 1548: 1542: 1541: 1539: 1538: 1526: 1514: 1513: 1512: 1500: 1499: 1498: 1493: 1488: 1483: 1471: 1458: 1456: 1452: 1451: 1448: 1447: 1445: 1444: 1435: 1433: 1413: 1412: 1410: 1409: 1397: 1386: 1384: 1369: 1368: 1366: 1365: 1359: 1354: 1349: 1333: 1332: 1326: 1321: 1316: 1300: 1298: 1291: 1290: 1288: 1287: 1275: 1273:Prolymphocytic 1269: 1267: 1260: 1259: 1257: 1256: 1244: 1231: 1229: 1222: 1221: 1219: 1209: 1207: 1198: 1187: 1186: 1185: 1153: 1152: 1142: 1140: 1139: 1132: 1125: 1117: 1108: 1107: 1104: 1103: 1092: 1081: 1066: 1050: 1045: 1044: 1042: 1041:Classification 1034: 1033:External links 1031: 1028: 1027: 992: 943: 889: 860:(8): 1468–72. 840: 789: 753: 712: 671: 636: 593: 572:(5): 1032–40. 549: 541: 490: 489: 487: 484: 463: 460: 454: 451: 449: 446: 441:Flow cytometry 437: 434: 402: 399: 387: 386: 383: 380: 377: 369: 366: 358: 355: 347: 346: 341: 336: 284: 281: 280: 279: 273: 267: 250: 249: 247:acute leukemia 243: 234: 228: 221: 213: 212: 209: 207:immunoglobulin 200: 194: 191: 179: 178: 175: 170: 168:Histopathology 165: 160: 146: 143: 135: 134: 129: 124: 115: 114: 109: 99: 98:Classification 96: 59: 58: 49: 43: 42: 39: 35: 34: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 2112: 2101: 2098: 2096: 2093: 2092: 2090: 2075: 2072: 2070: 2067: 2065: 2062: 2060: 2057: 2055: 2052: 2051: 2049: 2045: 2039: 2036: 2032: 2029: 2027: 2024: 2023: 2022: 2019: 2018: 2016: 2014: 2010: 2000: 1997: 1995: 1992: 1989: 1986: 1984: 1980: 1977: 1976: 1974: 1972: 1971:Lymphocytosis 1968: 1962: 1959: 1958: 1956: 1950: 1940: 1937: 1934: 1930: 1926: 1925: 1921: 1920: 1918: 1914: 1908: 1905: 1903: 1900: 1899: 1897: 1894: 1888: 1884: 1873: 1869: 1868: 1864: 1863: 1861: 1857: 1851: 1848: 1845: 1841: 1838: 1836: 1833: 1831: 1828: 1826: 1825:Hepatosplenic 1823: 1822: 1820: 1818: 1812: 1802: 1799: 1797: 1794: 1792: 1788: 1785: 1784: 1781: 1778: 1776: 1773: 1771: 1767: 1764: 1763: 1761: 1757: 1751: 1748: 1747: 1746: 1745: 1742: 1736: 1733: 1731: 1728: 1726: 1723: 1720: 1719: 1717: 1715: 1711: 1708: 1706: 1702: 1695: 1692: 1690: 1686: 1685: 1681: 1680: 1676: 1672: 1671: 1670:prolymphocyte 1667: 1666: 1663: 1659: 1655: 1652: 1650: 1642: 1639: 1634: 1631: 1629: 1626: 1625: 1624: 1618: 1613: 1608: 1604: 1601: 1599: 1595: 1585: 1582: 1580: 1579:Plasmacytosis 1577: 1575: 1572: 1570: 1567: 1565: 1562: 1560: 1557: 1555: 1552: 1551: 1549: 1547: 1543: 1536: 1535:MALT lymphoma 1532: 1531: 1527: 1524: 1520: 1519: 1515: 1511: 1508: 1507: 1506: 1505: 1501: 1497: 1494: 1492: 1489: 1487: 1484: 1482: 1479: 1478: 1477: 1476: 1472: 1469: 1465: 1464: 1460: 1459: 1457: 1453: 1443: 1442: 1437: 1436: 1434: 1431: 1427: 1422: 1418: 1414: 1407: 1403: 1402: 1398: 1395: 1391: 1388: 1387: 1385: 1382: 1378: 1374: 1370: 1363: 1360: 1358: 1355: 1353: 1350: 1348: 1344: 1343: 1339: 1338:marginal zone 1335: 1334: 1330: 1327: 1325: 1322: 1320: 1317: 1315: 1311: 1310: 1306: 1302: 1301: 1299: 1296: 1292: 1285: 1281: 1280: 1276: 1274: 1271: 1270: 1268: 1265: 1261: 1254: 1250: 1249: 1245: 1242: 1238: 1237: 1233: 1232: 1230: 1227: 1223: 1217: 1213: 1210: 1208: 1206: 1202: 1199: 1191: 1188: 1183: 1180: 1179: 1178: 1172: 1167: 1162: 1158: 1154: 1149: 1145: 1138: 1133: 1131: 1126: 1124: 1119: 1118: 1115: 1102: 1098: 1097: 1093: 1091: 1087: 1086: 1082: 1080: 1076: 1075: 1071: 1067: 1065: 1061: 1060: 1056: 1052: 1051: 1048: 1043: 1039: 1032: 1023: 1019: 1015: 1011: 1008:(8): 433–41. 1007: 1003: 996: 993: 988: 984: 979: 974: 970: 966: 962: 958: 954: 947: 944: 939: 935: 930: 925: 920: 915: 911: 907: 903: 896: 894: 890: 885: 881: 876: 871: 867: 863: 859: 855: 851: 844: 841: 836: 832: 827: 822: 817: 812: 808: 804: 800: 793: 790: 785: 781: 777: 773: 770:(4): 304–11. 769: 765: 757: 754: 749: 745: 740: 735: 732:(5): 958–63. 731: 727: 723: 716: 713: 708: 704: 699: 694: 691:(5): 430–43. 690: 686: 682: 675: 672: 667: 663: 659: 655: 651: 647: 640: 637: 632: 628: 624: 620: 616: 612: 608: 604: 597: 594: 589: 585: 580: 575: 571: 567: 563: 556: 554: 550: 544: 538: 534: 526: 524: 522: 520: 518: 516: 514: 512: 510: 508: 506: 504: 502: 500: 498: 496: 492: 485: 483: 481: 476: 474: 468: 461: 459: 452: 447: 445: 442: 435: 433: 430: 426: 422: 420: 416: 412: 411:Anthracycline 408: 400: 398: 396: 392: 384: 381: 378: 375: 374: 373: 367: 365: 363: 356: 354: 352: 345: 342: 340: 337: 335: 332: 331: 330: 327: 325: 321: 317: 313: 309: 305: 301: 297: 292: 290: 282: 278: 274: 272: 268: 265: 261: 260: 259: 257: 248: 244: 242: 238: 235: 232: 229: 226: 222: 218: 215: 214: 210: 208: 204: 201: 199: 195: 192: 189: 184: 181: 180: 176: 174: 171: 169: 166: 164: 161: 158: 157: 154: 152: 144: 142: 140: 133: 130: 128: 125: 123: 120: 119: 118: 113: 110: 108: 105: 104: 103: 97: 95: 93: 89: 85: 81: 77: 73: 69: 65: 57: 53: 50: 48: 44: 40: 36: 31: 19: 2073: 1922: 1865: 1859:By infection 1740: 1739: 1721: 1682: 1668: 1646:development/ 1574:Plasmacytoma 1528: 1516: 1502: 1473: 1461: 1455:By infection 1438: 1399: 1336: 1303: 1277: 1246: 1236:naive B cell 1234: 1195:development/ 1094: 1083: 1068: 1053: 1005: 1001: 995: 960: 956: 946: 909: 905: 857: 853: 843: 809:(1): 19–31. 806: 802: 792: 767: 763: 756: 729: 725: 715: 688: 684: 674: 652:(1): 48–60. 649: 645: 639: 609:(1): 18–23. 606: 602: 596: 569: 565: 547:8th edition. 532: 477: 469: 465: 456: 439: 423: 413:-containing 404: 388: 371: 360: 348: 328: 303: 293: 286: 253: 231:Lymphoblasts 173:Cell markers 148: 136: 116: 101: 74:, a type of 63: 62: 1741:aggressive: 1714:MF+variants 1253:Mantle cell 1248:mantle zone 685:Mod. Pathol 326:mutations. 72:lymphocytes 38:Other names 2089:Categories 1817:peripheral 1314:Follicular 1144:Leukaemias 764:Hematol. J 726:Ann. Oncol 566:Ann. Oncol 486:References 300:adolescent 205:, surface 190:: 9823/3) 56:hematology 1952:Lymphoid+ 1722:indolent: 1705:Cutaneous 1546:Cutaneous 1324:GCB DLBCL 1319:Burkitt's 1148:lymphomas 1096:SNOMED CT 448:Treatment 436:Diagnosis 401:Treatment 368:Diagnosis 275:9940/3 – 269:9833/3 – 262:9826/3 – 177:Comments 163:Incidence 80:lymphomas 68:leukemias 47:Specialty 2095:Leukemia 2059:leukemia 1617:leukemia 1612:lymphoma 1171:leukemia 1166:lymphoma 1101:32280000 1022:21507717 987:24941379 938:26303618 884:25925135 835:34661151 784:15297846 748:18303032 707:27015135 631:24785150 623:12894846 588:19850638 52:Oncology 2047:General 1954:myeloid 1916:T or NK 1887:NK cell 1241:CLL/SLL 1090:D007945 978:4066212 929:4548900 912:: 277. 875:4634362 826:8447273 666:2656019 289:T cells 258:code): 223:85% of 198:effaced 151:B cells 92:B cells 1891:(most 1867:HTLV-1 1759:Non-MF 1648:marker 1621:(most 1607:T cell 1279:CD11c+ 1197:marker 1175:(most 1161:B cell 1020:  985:  975:  936:  926:  882:  872:  833:  823:  782:  746:  705:  664:  629:  621:  586:  539:  324:NOTCH1 320:thymus 1814:Other 1684:CD30+ 1430:CD138 1401:CD20+ 1295:CD79a 627:S2CID 429:stage 256:ICD-O 188:ICD-O 1893:CD56 1787:CD30 1766:CD30 1654:TdT+ 1598:T/NK 1463:KSHV 1439:see 1426:CD38 1417:PCDs 1381:CD30 1377:CD15 1352:MALT 1264:CD22 1205:TdT+ 1182:CD20 1177:CD19 1085:MeSH 1074:9-CM 1018:PMID 983:PMID 934:PMID 880:PMID 831:PMID 780:PMID 744:PMID 703:PMID 662:PMID 619:PMID 584:PMID 537:ISBN 389:The 241:CD19 1924:EBV 1789:+: 1768:-: 1658:ALL 1633:CD8 1628:CD4 1623:CD3 1518:HIV 1504:HCV 1475:EBV 1379:+, 1226:CD5 1212:ALL 1079:204 1070:ICD 1064:C91 1055:ICD 1010:doi 973:PMC 965:doi 924:PMC 914:doi 870:PMC 862:doi 821:PMC 811:doi 772:doi 734:doi 693:doi 654:doi 611:doi 574:doi 421:. 312:CD7 308:CD2 237:TdT 203:CD5 2091:: 1656:: 1644:By 1432:+) 1428:+/ 1421:PP 1383:+) 1373:RS 1193:By 1146:, 1099:: 1088:: 1077:: 1062:: 1059:10 1016:. 1006:17 1004:. 981:. 971:. 961:19 959:. 955:. 932:. 922:. 910:13 908:. 904:. 892:^ 878:. 868:. 858:62 856:. 852:. 829:. 819:. 805:. 801:. 778:. 766:. 742:. 730:19 728:. 724:. 701:. 689:29 687:. 683:. 660:. 650:52 648:. 625:. 617:. 607:78 605:. 582:. 570:21 568:. 564:. 552:^ 494:^ 482:. 409:. 310:, 291:. 239:, 153:. 141:. 94:. 54:, 1990:) 1981:( 1935:) 1931:/ 1927:( 1895:) 1889:/ 1874:) 1870:( 1846:) 1842:( 1696:) 1687:( 1677:) 1673:( 1664:) 1660:( 1635:) 1619:) 1614:, 1610:( 1537:) 1533:( 1525:) 1521:( 1470:) 1466:( 1424:( 1419:/ 1408:) 1404:( 1396:) 1392:( 1375:( 1364:) 1345:( 1340:/ 1331:) 1312:( 1307:/ 1297:+ 1286:) 1282:( 1266:+ 1255:) 1251:( 1243:) 1239:( 1228:+ 1218:) 1214:( 1184:) 1173:) 1168:, 1164:( 1136:e 1129:t 1122:v 1072:- 1057:- 1047:D 1024:. 1012:: 989:. 967:: 940:. 916:: 886:. 864:: 837:. 813:: 807:2 786:. 774:: 768:5 750:. 736:: 709:. 695:: 668:. 656:: 633:. 613:: 590:. 576:: 545:. 186:( 20:)

Index

B cell leukemia
Specialty
Oncology
hematology
leukemias
lymphocytes
white blood cell
lymphomas
adult T-cell leukemia/lymphoma
lymphoproliferative disorders
B cells
Acute lymphoblastic leukemia
Chronic lymphocytic leukemia
B-cell leukemia
T-cell leukemia
NK-cell leukemia
B-cell chronic lymphocytic leukemia
B cells
Incidence
Histopathology
Cell markers
B-cell chronic lymphocytic leukemia
ICD-O
effaced
CD5
immunoglobulin
Precursor B-cell lymphoblastic leukemia
acute leukemias
Lymphoblasts
TdT

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