216:. When combined with a different partner, most of the bZIP pairs bind to DNA sequences that each individual partner prefers. In some cases, dimerization of different bZIP partners can change the DNA sequence that the pair targets in a manner that could not have been predicted based on the preferences of each partner alone. This suggests that, as heterodimers, bZIP transcription factors are able to change their preferences for which location they target in the DNA. The ability of bZIP domain forming dimers with different partners greatly expands the locations on the genome to which bZIP transcription factors can bind and from which they can regulate gene expression.
127:
31:
271:) is a transcription repressor which play multiple roles in regulating various biological processes. The NFIL3 protein has 462 amino acids including a b-ZIP domain . The N-terminal portion of the domain contains the basic motif, which directly binds to DNA. The C-terminal portion of the b-ZIP domain contains an amphipathic leucine zipper region, which mediates homo- and hetero- dimerization.
147:
residues line up on the same side of the helix. This region of the alpha-helix - containing the leucines which line up - is called a ZIP domain, and leucines from each ZIP domain can weakly interact with leucines from other ZIP domains, reversibly holding their alpha-helices together (dimerization). When these alpha helices dimerize, the zipper is formed. The
286:) in binding with the D box elements in the DNA, which is one of the circadian transcription factor consensus sites. DBP is another bZIP protein and shows an opposite portfolio of expression level to that of NFIL3. When NFIL3 level is high, genes under control of the D box elements will be repressed. Overexpression of
212:
motif, namely TGA(G/C)TCA. The bZIP heterodimers exist in a variety of eukaryotes and are more common in organisms with higher evolution complexity. Heterodimeric bZIP proteins differ from homodimeric bZIP and from each other in protein-protein interaction affinity. These heterodimers exhibit complex DNA binding
174:
in which the amino acids are designated from a’ to g’. While residues in positions a and d are generally hydrophobic and form a zigzag pattern of knobs and holes that interlock with a similar pattern on another strand to form a tight-fitting hydrophobic core, residues in positions e and g are charged
113:
binding basic region and a more diversified leucine zipper dimerization region. The localization of the leucines are critical for the DNA binding to the proteins. Leucine zippers are present in both eukaryotic and prokaryotic regulatory proteins, but are mainly a feature of eukaryotes. They can also
146:
interaction between two ZIP domains. The ZIP domain is found in the alpha-helix of each monomer, and contains leucines, or leucine-like amino acids. These amino acids are spaced out in each region's polypeptide sequence in such a way that when the sequence is coiled in a 3D alpha-helix, the leucine
211:
of the DNA, forming sequence-specific interactions. The mechanism of transcriptional regulation by bZIP proteins has been studied in detail. Most bZIP proteins show high binding affinity for the ACGT motifs, which include CACGTG (G box), GACGTC (C box), TACGTA (A box), AACGTT (T box), and a GCN4
178:
In the case of leucine zippers, leucines are predominant at the d position of the heptad repeat. These residues pack against each other every second turn of the alpha-helices, and the hydrophobic region between two helices is completed by residues at the a positions, which are also frequently
182:
Two different types of such a-helices can pair up to form a heterodimeric leucine zipper. With apolar amino acid residues at either the e or g position, a heterotetramer consisting of 2 different leucine zippers can be generated in-vitro, which implies that the overall hydrophobicity of the
328:), which downregulates target genes of CREB and CEBP to counteract the effect of cAMP signaling. Meanwhile, NFIL3 binds to its own promoter to repress its own expression, creating a negative feedback regulation of neuron regeneration.
170:. Coiled coils contain 3- and 4-residue repeats whose hydrophobicity pattern and residue composition is compatible with the structure of amphipathic alpha-helices. The alternating three- and four-residue sequence elements constitute
86:
residues at every seventh position over a distance covering eight helical turns. The polypeptide segments containing these periodic arrays of leucine residues were proposed to exist in an alpha-helical conformation and the leucine
1142:
179:
hydrophobic. They are referred to as coiled coils unless they are proven to be important for protein function. If that is the case, then they are annotated in the “domain” subsection, which would be the bZIP domain.
309:) to cell death genes, which undermines cell cycle and promotes oncogenesis. In colon cancer, NFIL3 may also block the recruitment of another type of transcription factors, Proline Acid Rich (PAR) proteins.
1135:
305:) and TNF receptor superfamily member 6 (FAS) to prevent apoptosis. NFIL3 can also hinder apoptosis in cancer cells by binding to DNA and block the access of transcription factor Forkhead box O1 (
2064:
297:
cell death in numerous cell types and leads to oncogenesis. High expression level of NFIL3 is shown associate with breast cancer. In cancer cells, NFIL3 associates with
Histone deacetylase2 (
6554:
1128:
2563:
4770:
114:
be annotated simply as ZIPs, and ZIP-like motifs have been found in proteins other than transcription factors and are thought to be one of the general protein modules for
223:. However, the others, including LIP19, OsZIP-2a, and OsZIP-2b, do not bind to DNA sequences. Instead, these bZIP proteins form heterodimers with other bZIPs to regulate
3448:
2470:
2465:
2460:
2109:
2094:
1780:
2603:
282:
and the NFIL3, as a repression factor, regulates circadian rhythm. NFIL3 competes with the transcription activator D site albumin promoter binding protein (
6398:
6382:
1201:
2455:
2240:
2233:
2228:
2216:
2211:
2206:
2201:
2196:
2124:
6120:
2919:
389:
Landschulz WH, Johnson PF, McKnight SL (June 1988). "The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins".
1978:
369:
5883:
1775:
1347:
6574:
6152:
5051:
3138:
440:
Vinson CR, Sigler PB, McKnight SL (November 1989). "Scissors-grip model for DNA recognition by a family of leucine zipper proteins".
130:
Another DNA binding domain, the Helix-loop-helix (HLH) dimer, is shown bound to DNA fragment — each alpha helix represents a monomer.
2596:
2591:
2519:
2509:
1386:
1376:
1211:
2514:
2428:
115:
6579:
5450:
2726:
2716:
1317:
1196:
325:
3081:
2721:
2416:
688:
544:
335:
and vital for the development and function of other immune cells, including but not limited to anti-inflammatory response in
6363:
6358:
5509:
2421:
6458:
4794:
2944:
2497:
2487:
151:
side of the helix forms a dimer with itself or another similar helix, burying the non-polar amino acids away from the
91:
from one alpha helix interdigitate with those from the alpha helix of a second polypeptide, facilitating dimerization.
4963:
4958:
4509:
2586:
2504:
2492:
1568:
961:"Characterization of three rice basic/leucine zipper factors, including two inhibitors of EmBP-1 DNA binding activity"
243:(the AP1 transcription factor), important regulators of normal development, as well as myc family members including
2699:
1697:
920:"LIP19, a basic region leucine zipper protein, is a Fos-like molecular switch in the cold signaling of rice plants"
6115:
2996:
2981:
2964:
2959:
2954:
2949:
2860:
2835:
2711:
2623:
2613:
1770:
1243:
324:), and the NFIL3 protein in turn competes for binding sites shared with CREB and CCAAT/Enhancer Binding Protein (
628:
Mason JM, Arndt KM (February 2004). "Coiled coil domains: stability, specificity, and biological implications".
560:
Hodges RS, Sodek J, Smillie LB, Jurasek L (1973). "Tropomyosin: Amino Acid
Sequence and Coiled-Coil Structure".
293:
NFIL3 influences cell survival and involves in oncogenesis. NFIL3 is shown to be a survival factor that hinders
70:
in proteins. They were first described by
Landschulz and collaborators in 1988 when they found that an enhancer
5857:
5492:
5008:
4581:
4420:
3355:
3350:
3335:
2810:
2785:
2667:
2618:
2411:
1802:
1268:
1114:
224:
196:
757:"Genomic survey and gene expression analysis of the basic leucine zipper transcription factor family in rice"
6222:
4263:
3580:
2694:
2682:
187:
may alter the organization of coiled coils and play a role in the formation of leucine zipper heterodimer.
6353:
4400:
4395:
2790:
2687:
2482:
2443:
1506:
1155:
316:
is expressed in neuron cells with regeneration potential to keep cell growth under control. Expression of
6345:
5905:
2704:
2640:
2635:
2448:
1524:
298:
5926:
5918:
3756:
3238:
2763:
2758:
2753:
2433:
2316:
1151:
817:
449:
398:
332:
220:
213:
102:
1120:
6240:
5944:
5640:
3843:
3048:
2630:
2608:
2581:
2543:
2477:
184:
75:
339:, production of IgE from B cells, maturation of CD8a dendritic cells and priming of CD8+ T cells.
5778:
1040:
653:
422:
301:) and represses pro-apoptotic genes such as Tumor necrosis factor ligand superfamily member 10 (
5360:
5351:
4988:
3936:
2677:
2672:
1089:
1032:
1024:
982:
941:
897:
843:
786:
737:
684:
645:
577:
540:
509:
465:
414:
365:
5171:
5166:
5161:
5156:
5151:
806:"Networks of bZIP protein-protein interactions diversified over a billion years of evolution"
4243:
3887:
3869:
2438:
2385:
2159:
1079:
1071:
1016:
972:
931:
887:
877:
833:
825:
776:
768:
727:
717:
676:
637:
608:
569:
532:
499:
457:
406:
67:
5331:
5326:
5276:
5266:
5246:
5231:
5211:
5136:
5116:
4258:
4253:
1110:
6028:
5251:
5121:
4487:
4445:
4440:
4435:
4373:
4285:
4207:
3995:
3946:
3941:
1988:
279:
166:, which are built by two or more alpha helices that are wound around each other to form a
71:
1060:"New Frontiers for the NFIL3 bZIP Transcription Factor in Cancer, Metabolism and Beyond"
821:
453:
402:
126:
30:
6125:
4405:
4388:
2531:
2186:
1084:
1059:
892:
865:
838:
805:
781:
756:
732:
705:
358:
336:
918:
Shimizu H, Sato K, Berberich T, Miyazaki A, Ozaki R, Imai R, Kusano T (October 2005).
864:
RodrĂguez-MartĂnez JA, Reinke AW, Bhimsaria D, Keating AE, Ansari AZ (February 2017).
6568:
4983:
4323:
2748:
2536:
1864:
1020:
195:
The bZIP interacts with the DNA via basic, amine residues (see basic amino acids in (
171:
135:
51:
35:
657:
6533:
5845:
5728:
5720:
5091:
5047:
4050:
3898:
1044:
722:
208:
1058:
Keniry, Megan; Dearth, Robert K.; Persans, Michael; Parsons, Ramon (2014-06-30).
426:
6217:
5820:
4300:
4015:
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2369:
2174:
2169:
1612:
1416:
1411:
1307:
1187:
573:
163:
156:
148:
143:
95:
79:
47:
1004:
6529:
6480:
5952:
5556:
5465:
5445:
5418:
4765:
4514:
4363:
4351:
4346:
3345:
3340:
2104:
2099:
2077:
1943:
1761:
1465:
1406:
1401:
1381:
866:"Combinatorial bZIP dimers display complex DNA-binding specificity landscapes"
613:
596:
283:
248:
106:
99:
88:
1028:
977:
960:
581:
504:
487:
6403:
6393:
6376:
5850:
4869:
2574:
2003:
1661:
829:
680:
536:
461:
410:
294:
167:
17:
1093:
945:
901:
847:
790:
741:
649:
641:
513:
263:
BZIP containing transcription factors regulate various biological processes
1036:
986:
772:
469:
418:
5870:
5648:
4010:
2569:
2526:
1578:
936:
919:
204:
74:
had a very characteristic 30-amino acid segment and the display of these
882:
312:
NFIL3 functions as a repressor to neuron regeneration associated genes.
6270:
6250:
6245:
5957:
3931:
3715:
1627:
1622:
1617:
1605:
1600:
152:
139:
83:
43:
1075:
331:
NFIL3 is also found to be important in immunology. It is required for
255:. If they are overproduced or mutated in a vital area, they may cause
6451:
6446:
6441:
6431:
6426:
6145:
5700:
5695:
5690:
5685:
4951:
4946:
4823:
4818:
4813:
4798:
4789:
4784:
4779:
4758:
4672:
4667:
4455:
4450:
4430:
4425:
4415:
4410:
4248:
4200:
4195:
4190:
4185:
4155:
4150:
4145:
4140:
4110:
4060:
4055:
3818:
3738:
3710:
3705:
3700:
3695:
3690:
3685:
3680:
3675:
3670:
3665:
3660:
3655:
3650:
3645:
3640:
3635:
3630:
3625:
3615:
3610:
3605:
3600:
3595:
3590:
3585:
3575:
3570:
3565:
3525:
3478:
3473:
3468:
3463:
3458:
3453:
3443:
3431:
3426:
3192:
3187:
3182:
3064:
3059:
3031:
3026:
3011:
3006:
3001:
2991:
2986:
2974:
2969:
2341:
2336:
2331:
2326:
2321:
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2223:
2191:
2134:
2129:
1916:
1911:
1906:
1790:
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1480:
1453:
1448:
1443:
1369:
256:
200:
704:
Deng Y, Liu J, Zheng Q, Li Q, Kallenbach NR, Lu M (September 2008).
320:
is induced by phosphorylated cAMP-response element binding protein (
267:
The bZIP-containing
Nuclear factor interleukin 3 regulated protein (
199:(sort by pH)) of certain amino acids in the "basic" domain, such as
6495:
6473:
6468:
6436:
6325:
6320:
6265:
6260:
6255:
6199:
6108:
6103:
6098:
6093:
6088:
6083:
6078:
6073:
6021:
6016:
6004:
5999:
5994:
5989:
5977:
5972:
5967:
5962:
5931:
5898:
5893:
5888:
5835:
5830:
5825:
5800:
5758:
5753:
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5743:
5738:
5733:
5705:
5658:
5653:
5599:
5594:
5589:
5584:
5561:
5336:
5321:
5316:
5311:
5306:
5301:
5296:
5291:
5286:
5281:
5271:
5261:
5256:
5241:
5236:
5226:
5221:
5216:
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5201:
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5191:
5186:
5181:
5176:
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5141:
5131:
5126:
5111:
5106:
5101:
5096:
5030:
5025:
5020:
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4803:
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4738:
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4130:
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4000:
3825:
3813:
3808:
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3560:
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3535:
3530:
3520:
3515:
3510:
3505:
3421:
3411:
3404:
3399:
3394:
3389:
3379:
3323:
3318:
3313:
3308:
3303:
3298:
3293:
3214:
3209:
3204:
3148:
3143:
3042:
3021:
3016:
2890:
2885:
2880:
2875:
2870:
2865:
2072:
1837:
1832:
1827:
1817:
1812:
1807:
1797:
1785:
1735:
1715:
1656:
1644:
1639:
1563:
1556:
1551:
1541:
1534:
1529:
1460:
1391:
1364:
1359:
1342:
1337:
1332:
1327:
1322:
1312:
1300:
1295:
1273:
1263:
1258:
1248:
306:
302:
268:
240:
236:
125:
29:
219:
A small number of bZIP factors such as OsOBF1 can also recognize
6522:
6517:
6512:
6502:
6490:
6485:
6332:
6315:
6179:
6174:
6169:
6140:
6135:
6068:
6063:
6058:
6053:
6048:
6043:
6038:
6033:
5984:
5878:
5840:
5815:
5810:
5805:
5788:
5680:
5673:
5668:
5549:
5544:
5539:
5534:
5529:
5524:
5519:
5514:
5504:
5497:
5487:
5482:
5470:
5460:
5455:
5438:
5433:
5428:
5411:
5406:
5401:
5376:
5371:
5366:
5084:
5079:
5074:
5069:
5064:
5003:
4978:
4973:
4914:
4909:
4904:
4899:
4894:
4889:
4884:
4879:
4874:
4845:
4840:
4733:
4728:
4723:
4718:
4704:
4699:
4694:
4689:
4684:
4655:
4650:
4645:
4611:
4606:
4601:
4596:
4591:
4586:
4551:
4539:
4534:
4529:
4482:
4477:
4472:
4467:
4462:
4383:
4368:
4358:
4334:
4329:
4315:
4310:
4305:
4295:
4290:
4278:
4273:
4217:
4212:
3990:
3975:
3970:
3958:
3953:
3786:
3781:
3776:
3620:
3555:
3500:
3495:
3490:
3374:
3369:
3364:
3288:
3283:
3278:
3273:
3268:
3263:
3258:
3253:
3248:
3231:
3226:
3170:
3165:
3133:
3128:
3123:
3113:
3108:
3101:
3096:
3091:
3086:
3076:
3071:
3054:
2912:
2907:
2902:
2830:
2291:
2286:
2281:
2276:
2271:
2266:
2179:
2164:
2141:
2114:
2087:
2082:
2047:
2025:
2020:
2015:
1998:
1993:
1983:
1973:
1923:
1881:
1876:
1859:
1854:
1849:
1747:
1742:
1730:
1688:
1683:
1673:
1588:
1583:
1573:
1492:
1475:
1438:
1426:
1421:
1396:
1354:
1283:
1278:
1253:
1236:
1231:
1226:
1221:
1216:
1206:
321:
252:
6293:
5622:
3864:
2364:
1166:
1124:
6164:
5793:
5783:
5663:
5059:
4616:
3965:
3416:
3153:
2647:
2119:
1948:
1938:
1933:
1725:
1720:
244:
110:
159:
side of the helix interacts with the water in the solvent.
755:
Nijhawan A, Jain M, Tyagi AK, Khurana JP (February 2008).
384:
382:
175:
residues contributing to the electrostatic interaction.
913:
911:
804:
Reinke AW, Baek J, Ashenberg O, Keating AE (May 2013).
481:
479:
6412:
6372:
6341:
6306:
6231:
6208:
6190:
5940:
5914:
5866:
5769:
5716:
5636:
5570:
5387:
5347:
5043:
4860:
4500:
4226:
3914:
3895:
3883:
3834:
3747:
3726:
2928:
2848:
2819:
2799:
2774:
2737:
2656:
2552:
2400:
2381:
2307:
2252:
2150:
2060:
2036:
1959:
1892:
1756:
1706:
1515:
1501:
1179:
562:
Cold Spring Harbor
Symposia on Quantitative Biology
488:"Mini review roles of the bZIP gene family in rice"
357:
162:Leucine zipper motifs are considered a subtype of
94:Leucine zippers are a dimerization motif of the
1003:Curran, Tom; Franza, B.Robert (November 1988).
597:"The packing of α-helices: simple coiled-coils"
671:Krylov D, Vinson CR (2001). "Leucine Zipper".
486:E ZG, Zhang YP, Zhou JH, Wang L (April 2014).
360:Glossary of Biochemistry and Molecular Biology
191:Specific binding between bZIP proteins and DNA
142:bound to DNA. The leucine zipper is formed by
6555:transcription factor/coregulator deficiencies
5626:β-Scaffold factors with minor groove contacts
1136:
8:
235:Leucine zipper regulatory proteins include
6303:
6290:
5633:
5619:
3911:
3892:
3880:
3861:
2397:
2378:
2361:
1512:
1176:
1163:
1143:
1129:
1121:
706:"A heterospecific leucine zipper tetramer"
1113:at the U.S. National Library of Medicine
1083:
976:
935:
891:
881:
837:
780:
731:
721:
612:
527:Hakoshima, T. (2005). "Leucine Zippers".
503:
959:Nantel A, Quatrano RS (December 1996).
348:
207:. These basic residues interact in the
98:(Basic-region leucine zipper) class of
998:
996:
859:
857:
7:
38:diagram, of a leucine zipper, where
2309:(1.6) Basic helix-span-helix (bHSH)
965:The Journal of Biological Chemistry
1005:"Fos and jun: The AP-1 connection"
109:in length with a highly conserved
82:revealed a periodic repetition of
25:
134:Leucine zipper is created by the
66:) is a common three-dimensional
6296:(0) Other transcription factors
5580:transcriptional enhancer factor
1197:Activating transcription factor
492:Genetics and Molecular Research
105:. The bZIP domain is 60 to 80
723:10.1016/j.chembiol.2008.07.008
290:shortens the circadian cycle.
1:
5510:Interferon regulatory factors
3749:(2.5) Alternating composition
2945:General transcription factors
673:Encyclopedia of Life Sciences
529:Encyclopedia of Life Sciences
4795:Octamer transcription factor
1503:(1.2) Basic helix-loop-helix
1021:10.1016/0092-8674(88)90024-4
278:gene changes along with the
138:of two specific alpha helix
116:protein–protein interactions
27:DNA-binding structural motif
1569:Myogenic regulatory factors
924:Plant & Cell Physiology
595:Crick FH (September 1953).
574:10.1101/SQB.1973.037.01.040
6596:
225:transcriptional activities
6575:Protein structural motifs
6550:
6302:
6289:
5632:
5618:
5389:(3.5) Tryptophan clusters
3879:
3860:
2377:
2360:
1175:
1162:
614:10.1107/s0365110x53001964
185:van der Waals interaction
6210:(4.10) Cold-shock domain
1115:Medical Subject Headings
978:10.1074/jbc.271.49.31296
505:10.4238/2014.April.16.11
183:interaction surface and
1156:intracellular receptors
830:10.1126/science.1233465
710:Chemistry & Biology
681:10.1038/npg.els.0003001
537:10.1038/npg.els.0005049
462:10.1126/science.2683088
411:10.1126/science.3289117
376:"hair cutting scissors"
6580:DNA-binding substances
642:10.1002/cbic.200300781
601:Acta Crystallographica
274:The expression of the
131:
122:Sequence and structure
55:
46:, arranged with other
5919:TATA-binding proteins
1152:Transcription factors
773:10.1104/pp.107.112821
221:palindromic sequences
129:
103:transcription factors
33:
333:natural killer cells
76:amino acid sequences
34:"Overhead view", or
6414:(0.6) Miscellaneous
5945:High-mobility group
5641:Rel homology region
2631:Testicular receptor
2372:DNA-binding domains
883:10.7554/eLife.19272
822:2013Sci...340..730R
607:(6 (8-9)): 689–97.
454:1989Sci...246..911V
403:1988Sci...240.1759L
5779:p53 p63 p73 family
5352:Heat shock factors
937:10.1093/pcp/pci178
364:. Portland Press.
132:
56:
6562:
6561:
6546:
6545:
6542:
6541:
6285:
6284:
6281:
6280:
5614:
5613:
5610:
5609:
4856:
4855:
4496:
4495:
3856:
3855:
3852:
3851:
2844:
2843:
2700:Mineralocorticoid
2356:
2355:
2352:
2351:
2056:
2055:
1169:(1) Basic domains
1076:10.15190/d.2014.7
971:(49): 31296–305.
397:(4860): 1759–64.
371:978-1-85578-088-0
356:Glick DM (1997).
16:(Redirected from
6587:
6386:-related factors
6304:
6291:
6192:(4.9) Grainyhead
5634:
5620:
5572:(3.6) TEA domain
4862:(3.2) Paired box
4503:
4237:
4231:
3925:
3919:
3912:
3908:
3902:
3893:
3881:
3870:Helix-turn-helix
3862:
2824:
2804:
2779:
2742:
2712:Estrogen related
2661:
2557:
2405:
2398:
2386:Nuclear receptor
2379:
2362:
2041:
1962:
1895:
1764:
1709:
1518:
1513:
1177:
1164:
1145:
1138:
1131:
1122:
1098:
1097:
1087:
1055:
1049:
1048:
1000:
991:
990:
980:
956:
950:
949:
939:
915:
906:
905:
895:
885:
861:
852:
851:
841:
801:
795:
794:
784:
761:Plant Physiology
752:
746:
745:
735:
725:
701:
695:
694:
668:
662:
661:
625:
619:
618:
616:
592:
586:
585:
557:
551:
550:
524:
518:
517:
507:
483:
474:
473:
437:
431:
430:
386:
377:
375:
363:
353:
78:on an idealized
68:structural motif
64:leucine scissors
50:on two parallel
21:
6595:
6594:
6590:
6589:
6588:
6586:
6585:
6584:
6565:
6564:
6563:
6558:
6538:
6408:
6368:
6337:
6298:
6277:
6227:
6204:
6186:
5936:
5910:
5862:
5765:
5712:
5628:
5606:
5566:
5383:
5343:
5039:
4852:
4501:
4492:
4233:
4232:
4227:
4222:
3921:
3920:
3915:
3904:
3903:
3896:
3875:
3848:
3830:
3743:
3731:
3722:
2937:
2933:
2924:
2853:
2850:(2.2) Other Cys
2840:
2820:
2815:
2800:
2795:
2775:
2770:
2738:
2733:
2668:Steroid hormone
2657:
2652:
2553:
2548:
2412:Thyroid hormone
2401:
2392:
2373:
2348:
2303:
2248:
2146:
2052:
2039:
2037:
2032:
1960:
1955:
1893:
1888:
1759:
1757:
1752:
1707:
1702:
1516:
1497:
1171:
1158:
1149:
1111:Leucine+zippers
1107:
1102:
1101:
1057:
1056:
1052:
1002:
1001:
994:
958:
957:
953:
930:(10): 1623–34.
917:
916:
909:
863:
862:
855:
816:(6133): 730–4.
803:
802:
798:
754:
753:
749:
703:
702:
698:
691:
670:
669:
665:
627:
626:
622:
594:
593:
589:
559:
558:
554:
547:
526:
525:
521:
485:
484:
477:
448:(4932): 911–6.
439:
438:
434:
388:
387:
380:
372:
355:
354:
350:
345:
280:circadian cycle
265:
233:
193:
124:
72:binding protein
28:
23:
22:
15:
12:
11:
5:
6593:
6591:
6583:
6582:
6577:
6567:
6566:
6560:
6559:
6551:
6548:
6547:
6544:
6543:
6540:
6539:
6537:
6536:
6527:
6526:
6525:
6520:
6515:
6505:
6500:
6499:
6498:
6493:
6488:
6478:
6477:
6476:
6471:
6461:
6456:
6455:
6454:
6449:
6444:
6439:
6434:
6429:
6418:
6416:
6410:
6409:
6407:
6406:
6401:
6396:
6390:
6388:
6370:
6369:
6367:
6366:
6361:
6356:
6350:
6348:
6339:
6338:
6336:
6335:
6330:
6329:
6328:
6323:
6312:
6310:
6300:
6299:
6294:
6287:
6286:
6283:
6282:
6279:
6278:
6276:
6275:
6274:
6273:
6268:
6263:
6258:
6253:
6248:
6237:
6235:
6229:
6228:
6226:
6225:
6220:
6214:
6212:
6206:
6205:
6203:
6202:
6196:
6194:
6188:
6187:
6185:
6184:
6183:
6182:
6177:
6172:
6167:
6157:
6156:
6155:
6150:
6149:
6148:
6143:
6138:
6123:
6118:
6113:
6112:
6111:
6106:
6101:
6096:
6091:
6086:
6081:
6076:
6071:
6066:
6061:
6056:
6051:
6046:
6041:
6036:
6026:
6025:
6024:
6019:
6009:
6008:
6007:
6002:
5997:
5992:
5982:
5981:
5980:
5975:
5970:
5965:
5955:
5949:
5947:
5938:
5937:
5935:
5934:
5929:
5923:
5921:
5912:
5911:
5909:
5908:
5903:
5902:
5901:
5896:
5891:
5886:
5875:
5873:
5864:
5863:
5861:
5860:
5855:
5854:
5853:
5848:
5843:
5838:
5833:
5828:
5823:
5818:
5813:
5808:
5798:
5797:
5796:
5791:
5786:
5775:
5773:
5771:(4.3) p53-like
5767:
5766:
5764:
5763:
5762:
5761:
5756:
5751:
5746:
5741:
5736:
5725:
5723:
5714:
5713:
5711:
5710:
5709:
5708:
5703:
5698:
5693:
5688:
5678:
5677:
5676:
5671:
5666:
5661:
5656:
5645:
5643:
5630:
5629:
5623:
5616:
5615:
5612:
5611:
5608:
5607:
5605:
5604:
5603:
5602:
5597:
5592:
5587:
5576:
5574:
5568:
5567:
5565:
5564:
5559:
5554:
5553:
5552:
5547:
5542:
5537:
5532:
5527:
5522:
5517:
5507:
5502:
5501:
5500:
5495:
5490:
5485:
5475:
5474:
5473:
5468:
5463:
5458:
5448:
5443:
5442:
5441:
5436:
5431:
5421:
5416:
5415:
5414:
5409:
5404:
5393:
5391:
5385:
5384:
5382:
5381:
5380:
5379:
5374:
5369:
5356:
5354:
5345:
5344:
5342:
5341:
5340:
5339:
5334:
5329:
5324:
5319:
5314:
5309:
5304:
5299:
5294:
5289:
5284:
5279:
5274:
5269:
5264:
5259:
5254:
5249:
5244:
5239:
5234:
5229:
5224:
5219:
5214:
5209:
5204:
5199:
5194:
5189:
5184:
5179:
5174:
5169:
5164:
5159:
5154:
5149:
5144:
5139:
5134:
5129:
5124:
5119:
5114:
5109:
5104:
5099:
5089:
5088:
5087:
5082:
5077:
5072:
5067:
5056:
5054:
5041:
5040:
5038:
5037:
5036:
5035:
5034:
5033:
5028:
5023:
5013:
5012:
5011:
5006:
4996:
4991:
4981:
4976:
4971:
4966:
4961:
4956:
4955:
4954:
4949:
4939:
4934:
4933:
4932:
4927:
4919:
4918:
4917:
4912:
4907:
4902:
4897:
4892:
4887:
4882:
4877:
4866:
4864:
4858:
4857:
4854:
4853:
4851:
4850:
4849:
4848:
4843:
4833:
4828:
4827:
4826:
4821:
4816:
4811:
4806:
4801:
4792:
4787:
4782:
4773:
4763:
4762:
4761:
4756:
4751:
4746:
4741:
4736:
4731:
4726:
4721:
4711:
4710:
4709:
4708:
4707:
4702:
4697:
4692:
4687:
4677:
4676:
4675:
4670:
4660:
4659:
4658:
4653:
4648:
4638:
4637:
4636:
4631:
4621:
4620:
4619:
4614:
4609:
4604:
4599:
4594:
4589:
4576:
4571:
4570:
4569:
4564:
4554:
4549:
4544:
4543:
4542:
4537:
4532:
4522:
4517:
4512:
4506:
4504:
4498:
4497:
4494:
4493:
4491:
4490:
4485:
4480:
4475:
4470:
4465:
4460:
4459:
4458:
4453:
4448:
4443:
4438:
4433:
4428:
4423:
4418:
4413:
4408:
4398:
4393:
4392:
4391:
4386:
4376:
4371:
4366:
4361:
4356:
4355:
4354:
4349:
4339:
4338:
4337:
4332:
4320:
4319:
4318:
4313:
4308:
4303:
4298:
4293:
4283:
4282:
4281:
4276:
4266:
4261:
4256:
4251:
4246:
4240:
4238:
4224:
4223:
4221:
4220:
4215:
4210:
4205:
4204:
4203:
4198:
4193:
4188:
4183:
4178:
4173:
4168:
4163:
4158:
4153:
4148:
4143:
4138:
4133:
4128:
4123:
4118:
4113:
4108:
4103:
4098:
4093:
4088:
4083:
4078:
4073:
4068:
4063:
4058:
4053:
4048:
4043:
4038:
4033:
4028:
4023:
4018:
4008:
4003:
3998:
3993:
3989:extended Hox:
3987:
3986:
3985:
3984:
3983:
3978:
3973:
3963:
3962:
3961:
3951:
3950:
3949:
3944:
3928:
3926:
3909:
3890:
3877:
3876:
3865:
3858:
3857:
3854:
3853:
3850:
3849:
3847:
3846:
3840:
3838:
3832:
3831:
3829:
3828:
3823:
3822:
3821:
3816:
3811:
3806:
3801:
3791:
3790:
3789:
3784:
3779:
3769:
3764:
3759:
3753:
3751:
3745:
3744:
3742:
3741:
3735:
3733:
3729:
3724:
3723:
3721:
3720:
3719:
3718:
3713:
3708:
3703:
3698:
3693:
3688:
3683:
3678:
3673:
3668:
3663:
3658:
3653:
3648:
3643:
3638:
3633:
3628:
3623:
3618:
3613:
3608:
3603:
3598:
3593:
3588:
3583:
3578:
3573:
3568:
3563:
3558:
3553:
3548:
3543:
3538:
3533:
3528:
3523:
3518:
3513:
3508:
3503:
3498:
3493:
3483:
3482:
3481:
3476:
3471:
3466:
3461:
3456:
3451:
3446:
3436:
3435:
3434:
3429:
3419:
3414:
3409:
3408:
3407:
3402:
3397:
3392:
3382:
3377:
3372:
3367:
3362:
3361:
3360:
3359:
3358:
3353:
3348:
3343:
3338:
3328:
3327:
3326:
3321:
3316:
3311:
3306:
3301:
3296:
3291:
3286:
3281:
3276:
3271:
3266:
3261:
3256:
3251:
3236:
3235:
3234:
3229:
3219:
3218:
3217:
3212:
3207:
3197:
3196:
3195:
3190:
3185:
3175:
3174:
3173:
3168:
3158:
3157:
3156:
3151:
3146:
3141:
3136:
3131:
3126:
3116:
3111:
3106:
3105:
3104:
3099:
3094:
3089:
3079:
3074:
3069:
3068:
3067:
3062:
3057:
3045:
3039:
3038:
3037:
3036:
3035:
3034:
3029:
3024:
3019:
3014:
3009:
3004:
2999:
2989:
2984:
2979:
2978:
2977:
2972:
2962:
2957:
2952:
2941:
2939:
2935:
2931:
2926:
2925:
2923:
2922:
2917:
2916:
2915:
2910:
2905:
2895:
2894:
2893:
2888:
2883:
2878:
2873:
2868:
2857:
2855:
2851:
2846:
2845:
2842:
2841:
2839:
2838:
2833:
2827:
2825:
2817:
2816:
2814:
2813:
2807:
2805:
2797:
2796:
2794:
2793:
2788:
2782:
2780:
2772:
2771:
2769:
2768:
2767:
2766:
2761:
2756:
2745:
2743:
2735:
2734:
2732:
2731:
2730:
2729:
2724:
2719:
2709:
2708:
2707:
2702:
2697:
2695:Glucocorticoid
2692:
2691:
2690:
2685:
2675:
2664:
2662:
2654:
2653:
2651:
2650:
2645:
2644:
2643:
2638:
2628:
2627:
2626:
2621:
2616:
2606:
2601:
2600:
2599:
2594:
2584:
2579:
2578:
2577:
2572:
2560:
2558:
2550:
2549:
2547:
2546:
2541:
2540:
2539:
2534:
2524:
2523:
2522:
2517:
2512:
2502:
2501:
2500:
2495:
2490:
2480:
2475:
2474:
2473:
2468:
2463:
2453:
2452:
2451:
2446:
2436:
2431:
2426:
2425:
2424:
2419:
2408:
2406:
2395:
2390:
2375:
2374:
2365:
2358:
2357:
2354:
2353:
2350:
2349:
2347:
2346:
2345:
2344:
2339:
2334:
2329:
2324:
2313:
2311:
2305:
2304:
2302:
2301:
2300:
2299:
2294:
2289:
2284:
2279:
2274:
2269:
2258:
2256:
2250:
2249:
2247:
2246:
2245:
2244:
2238:
2237:
2236:
2231:
2221:
2220:
2219:
2214:
2209:
2204:
2199:
2184:
2183:
2182:
2177:
2172:
2167:
2156:
2154:
2148:
2147:
2145:
2144:
2139:
2138:
2137:
2132:
2122:
2117:
2112:
2107:
2102:
2097:
2092:
2091:
2090:
2085:
2075:
2069:
2067:
2058:
2057:
2054:
2053:
2051:
2050:
2044:
2042:
2034:
2033:
2031:
2030:
2029:
2028:
2023:
2018:
2008:
2007:
2006:
2001:
1996:
1991:
1986:
1981:
1976:
1965:
1963:
1957:
1956:
1954:
1953:
1952:
1951:
1946:
1941:
1936:
1926:
1921:
1920:
1919:
1914:
1909:
1898:
1896:
1890:
1889:
1887:
1886:
1885:
1884:
1879:
1869:
1868:
1867:
1862:
1857:
1852:
1842:
1841:
1840:
1835:
1830:
1822:
1821:
1820:
1815:
1810:
1800:
1795:
1794:
1793:
1788:
1778:
1773:
1767:
1765:
1754:
1753:
1751:
1750:
1745:
1740:
1739:
1738:
1733:
1728:
1718:
1712:
1710:
1704:
1703:
1701:
1700:
1695:
1694:
1693:
1692:
1691:
1686:
1676:
1666:
1665:
1664:
1659:
1649:
1648:
1647:
1642:
1632:
1631:
1630:
1625:
1620:
1610:
1609:
1608:
1603:
1593:
1592:
1591:
1586:
1581:
1576:
1566:
1561:
1560:
1559:
1554:
1544:
1539:
1538:
1537:
1532:
1521:
1519:
1510:
1499:
1498:
1496:
1495:
1490:
1489:
1488:
1483:
1478:
1468:
1463:
1458:
1457:
1456:
1451:
1446:
1441:
1431:
1430:
1429:
1424:
1419:
1414:
1404:
1399:
1394:
1389:
1384:
1379:
1374:
1373:
1372:
1367:
1362:
1352:
1351:
1350:
1345:
1340:
1335:
1330:
1325:
1315:
1310:
1305:
1304:
1303:
1298:
1288:
1287:
1286:
1281:
1276:
1271:
1266:
1261:
1256:
1251:
1241:
1240:
1239:
1234:
1229:
1224:
1219:
1214:
1209:
1204:
1193:
1191:
1184:leucine zipper
1173:
1172:
1167:
1160:
1159:
1150:
1148:
1147:
1140:
1133:
1125:
1119:
1118:
1106:
1105:External links
1103:
1100:
1099:
1050:
1015:(3): 395–397.
992:
951:
907:
853:
796:
747:
696:
689:
663:
620:
587:
552:
545:
519:
498:(2): 3025–36.
475:
432:
378:
370:
347:
346:
344:
341:
337:helper T cells
264:
261:
232:
229:
197:provided table
192:
189:
172:heptad repeats
123:
120:
60:leucine zipper
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6592:
6581:
6578:
6576:
6573:
6572:
6570:
6557:
6556:
6549:
6535:
6531:
6528:
6524:
6521:
6519:
6516:
6514:
6511:
6510:
6509:
6506:
6504:
6501:
6497:
6494:
6492:
6489:
6487:
6484:
6483:
6482:
6479:
6475:
6472:
6470:
6467:
6466:
6465:
6462:
6460:
6457:
6453:
6450:
6448:
6445:
6443:
6440:
6438:
6435:
6433:
6430:
6428:
6425:
6424:
6423:
6420:
6419:
6417:
6415:
6411:
6405:
6402:
6400:
6397:
6395:
6392:
6391:
6389:
6387:
6384:
6381:
6378:
6375:
6371:
6365:
6362:
6360:
6357:
6355:
6352:
6351:
6349:
6347:
6346:Pocket domain
6344:
6340:
6334:
6331:
6327:
6324:
6322:
6319:
6318:
6317:
6314:
6313:
6311:
6309:
6308:(0.2) HMGI(Y)
6305:
6301:
6297:
6292:
6288:
6272:
6269:
6267:
6264:
6262:
6259:
6257:
6254:
6252:
6249:
6247:
6244:
6243:
6242:
6239:
6238:
6236:
6234:
6230:
6224:
6221:
6219:
6216:
6215:
6213:
6211:
6207:
6201:
6198:
6197:
6195:
6193:
6189:
6181:
6178:
6176:
6173:
6171:
6168:
6166:
6163:
6162:
6161:
6158:
6154:
6151:
6147:
6144:
6142:
6139:
6137:
6134:
6133:
6132:
6129:
6128:
6127:
6124:
6122:
6119:
6117:
6114:
6110:
6107:
6105:
6102:
6100:
6097:
6095:
6092:
6090:
6087:
6085:
6082:
6080:
6077:
6075:
6072:
6070:
6067:
6065:
6062:
6060:
6057:
6055:
6052:
6050:
6047:
6045:
6042:
6040:
6037:
6035:
6032:
6031:
6030:
6027:
6023:
6020:
6018:
6015:
6014:
6013:
6010:
6006:
6003:
6001:
5998:
5996:
5993:
5991:
5988:
5987:
5986:
5983:
5979:
5976:
5974:
5971:
5969:
5966:
5964:
5961:
5960:
5959:
5956:
5954:
5951:
5950:
5948:
5946:
5943:
5939:
5933:
5930:
5928:
5925:
5924:
5922:
5920:
5917:
5913:
5907:
5904:
5900:
5897:
5895:
5892:
5890:
5887:
5885:
5882:
5881:
5880:
5877:
5876:
5874:
5872:
5869:
5865:
5859:
5856:
5852:
5849:
5847:
5844:
5842:
5839:
5837:
5834:
5832:
5829:
5827:
5824:
5822:
5819:
5817:
5814:
5812:
5809:
5807:
5804:
5803:
5802:
5799:
5795:
5792:
5790:
5787:
5785:
5782:
5781:
5780:
5777:
5776:
5774:
5772:
5768:
5760:
5757:
5755:
5752:
5750:
5747:
5745:
5742:
5740:
5737:
5735:
5732:
5731:
5730:
5727:
5726:
5724:
5722:
5719:
5715:
5707:
5704:
5702:
5699:
5697:
5694:
5692:
5689:
5687:
5684:
5683:
5682:
5679:
5675:
5672:
5670:
5667:
5665:
5662:
5660:
5657:
5655:
5652:
5651:
5650:
5647:
5646:
5644:
5642:
5639:
5635:
5631:
5627:
5621:
5617:
5601:
5598:
5596:
5593:
5591:
5588:
5586:
5583:
5582:
5581:
5578:
5577:
5575:
5573:
5569:
5563:
5560:
5558:
5555:
5551:
5548:
5546:
5543:
5541:
5538:
5536:
5533:
5531:
5528:
5526:
5523:
5521:
5518:
5516:
5513:
5512:
5511:
5508:
5506:
5503:
5499:
5496:
5494:
5491:
5489:
5486:
5484:
5481:
5480:
5479:
5476:
5472:
5469:
5467:
5464:
5462:
5459:
5457:
5454:
5453:
5452:
5449:
5447:
5444:
5440:
5437:
5435:
5432:
5430:
5427:
5426:
5425:
5422:
5420:
5417:
5413:
5410:
5408:
5405:
5403:
5400:
5399:
5398:
5395:
5394:
5392:
5390:
5386:
5378:
5375:
5373:
5370:
5368:
5365:
5364:
5363:
5362:
5358:
5357:
5355:
5353:
5350:
5346:
5338:
5335:
5333:
5330:
5328:
5325:
5323:
5320:
5318:
5315:
5313:
5310:
5308:
5305:
5303:
5300:
5298:
5295:
5293:
5290:
5288:
5285:
5283:
5280:
5278:
5275:
5273:
5270:
5268:
5265:
5263:
5260:
5258:
5255:
5253:
5250:
5248:
5245:
5243:
5240:
5238:
5235:
5233:
5230:
5228:
5225:
5223:
5220:
5218:
5215:
5213:
5210:
5208:
5205:
5203:
5200:
5198:
5195:
5193:
5190:
5188:
5185:
5183:
5180:
5178:
5175:
5173:
5170:
5168:
5165:
5163:
5160:
5158:
5155:
5153:
5150:
5148:
5145:
5143:
5140:
5138:
5135:
5133:
5130:
5128:
5125:
5123:
5120:
5118:
5115:
5113:
5110:
5108:
5105:
5103:
5100:
5098:
5095:
5094:
5093:
5090:
5086:
5083:
5081:
5078:
5076:
5073:
5071:
5068:
5066:
5063:
5062:
5061:
5058:
5057:
5055:
5053:
5049:
5046:
5042:
5032:
5029:
5027:
5024:
5022:
5019:
5018:
5017:
5014:
5010:
5007:
5005:
5002:
5001:
5000:
4997:
4995:
4992:
4990:
4987:
4986:
4985:
4982:
4980:
4977:
4975:
4972:
4970:
4967:
4965:
4962:
4960:
4957:
4953:
4950:
4948:
4945:
4944:
4943:
4940:
4938:
4935:
4931:
4928:
4926:
4923:
4922:
4920:
4916:
4913:
4911:
4908:
4906:
4903:
4901:
4898:
4896:
4893:
4891:
4888:
4886:
4883:
4881:
4878:
4876:
4873:
4872:
4871:
4868:
4867:
4865:
4863:
4859:
4847:
4844:
4842:
4839:
4838:
4837:
4834:
4832:
4829:
4825:
4822:
4820:
4817:
4815:
4812:
4810:
4807:
4805:
4802:
4800:
4796:
4793:
4791:
4788:
4786:
4783:
4781:
4777:
4774:
4772:
4769:
4768:
4767:
4764:
4760:
4757:
4755:
4752:
4750:
4747:
4745:
4742:
4740:
4737:
4735:
4732:
4730:
4727:
4725:
4722:
4720:
4717:
4716:
4715:
4712:
4706:
4703:
4701:
4698:
4696:
4693:
4691:
4688:
4686:
4683:
4682:
4681:
4678:
4674:
4671:
4669:
4666:
4665:
4664:
4661:
4657:
4654:
4652:
4649:
4647:
4644:
4643:
4642:
4639:
4635:
4632:
4630:
4627:
4626:
4625:
4622:
4618:
4615:
4613:
4610:
4608:
4605:
4603:
4600:
4598:
4595:
4593:
4590:
4588:
4585:
4584:
4583:
4580:
4579:
4577:
4575:
4572:
4568:
4565:
4563:
4560:
4559:
4558:
4555:
4553:
4550:
4548:
4545:
4541:
4538:
4536:
4533:
4531:
4528:
4527:
4526:
4523:
4521:
4518:
4516:
4513:
4511:
4508:
4507:
4505:
4499:
4489:
4486:
4484:
4481:
4479:
4476:
4474:
4471:
4469:
4466:
4464:
4461:
4457:
4454:
4452:
4449:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4427:
4424:
4422:
4419:
4417:
4414:
4412:
4409:
4407:
4404:
4403:
4402:
4399:
4397:
4394:
4390:
4387:
4385:
4382:
4381:
4380:
4377:
4375:
4372:
4370:
4367:
4365:
4362:
4360:
4357:
4353:
4350:
4348:
4345:
4344:
4343:
4340:
4336:
4333:
4331:
4328:
4327:
4326:
4325:
4321:
4317:
4314:
4312:
4309:
4307:
4304:
4302:
4299:
4297:
4294:
4292:
4289:
4288:
4287:
4284:
4280:
4277:
4275:
4272:
4271:
4270:
4267:
4265:
4262:
4260:
4257:
4255:
4252:
4250:
4247:
4245:
4242:
4241:
4239:
4236:
4230:
4225:
4219:
4216:
4214:
4211:
4209:
4206:
4202:
4199:
4197:
4194:
4192:
4189:
4187:
4184:
4182:
4179:
4177:
4174:
4172:
4169:
4167:
4164:
4162:
4159:
4157:
4154:
4152:
4149:
4147:
4144:
4142:
4139:
4137:
4134:
4132:
4129:
4127:
4124:
4122:
4119:
4117:
4114:
4112:
4109:
4107:
4104:
4102:
4099:
4097:
4094:
4092:
4089:
4087:
4084:
4082:
4079:
4077:
4074:
4072:
4069:
4067:
4064:
4062:
4059:
4057:
4054:
4052:
4049:
4047:
4044:
4042:
4039:
4037:
4034:
4032:
4029:
4027:
4024:
4022:
4019:
4017:
4014:
4013:
4012:
4009:
4007:
4004:
4002:
3999:
3997:
3994:
3992:
3988:
3982:
3979:
3977:
3974:
3972:
3969:
3968:
3967:
3964:
3960:
3957:
3956:
3955:
3952:
3948:
3945:
3943:
3940:
3939:
3938:
3935:
3934:
3933:
3930:
3929:
3927:
3924:
3918:
3913:
3910:
3907:
3901:
3900:
3894:
3891:
3889:
3886:
3882:
3878:
3874:
3871:
3868:
3863:
3859:
3845:
3842:
3841:
3839:
3837:
3833:
3827:
3824:
3820:
3817:
3815:
3812:
3810:
3807:
3805:
3802:
3800:
3797:
3796:
3795:
3792:
3788:
3785:
3783:
3780:
3778:
3775:
3774:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3754:
3752:
3750:
3746:
3740:
3737:
3736:
3734:
3732:
3725:
3717:
3714:
3712:
3709:
3707:
3704:
3702:
3699:
3697:
3694:
3692:
3689:
3687:
3684:
3682:
3679:
3677:
3674:
3672:
3669:
3667:
3664:
3662:
3659:
3657:
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3634:
3632:
3629:
3627:
3624:
3622:
3619:
3617:
3614:
3612:
3609:
3607:
3604:
3602:
3599:
3597:
3594:
3592:
3589:
3587:
3584:
3582:
3579:
3577:
3574:
3572:
3569:
3567:
3564:
3562:
3559:
3557:
3554:
3552:
3549:
3547:
3544:
3542:
3539:
3537:
3534:
3532:
3529:
3527:
3524:
3522:
3519:
3517:
3514:
3512:
3509:
3507:
3504:
3502:
3499:
3497:
3494:
3492:
3489:
3488:
3487:
3484:
3480:
3477:
3475:
3472:
3470:
3467:
3465:
3462:
3460:
3457:
3455:
3452:
3450:
3447:
3445:
3442:
3441:
3440:
3437:
3433:
3430:
3428:
3425:
3424:
3423:
3420:
3418:
3415:
3413:
3410:
3406:
3403:
3401:
3398:
3396:
3393:
3391:
3388:
3387:
3386:
3383:
3381:
3378:
3376:
3373:
3371:
3368:
3366:
3363:
3357:
3354:
3352:
3349:
3347:
3344:
3342:
3339:
3337:
3334:
3333:
3332:
3329:
3325:
3322:
3320:
3317:
3315:
3312:
3310:
3307:
3305:
3302:
3300:
3297:
3295:
3292:
3290:
3287:
3285:
3282:
3280:
3277:
3275:
3272:
3270:
3267:
3265:
3262:
3260:
3257:
3255:
3252:
3250:
3247:
3246:
3245:
3242:
3241:
3240:
3239:Sp/KLF family
3237:
3233:
3230:
3228:
3225:
3224:
3223:
3220:
3216:
3213:
3211:
3208:
3206:
3203:
3202:
3201:
3198:
3194:
3191:
3189:
3186:
3184:
3181:
3180:
3179:
3176:
3172:
3169:
3167:
3164:
3163:
3162:
3159:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3121:
3120:
3117:
3115:
3112:
3110:
3107:
3103:
3100:
3098:
3095:
3093:
3090:
3088:
3085:
3084:
3083:
3080:
3078:
3075:
3073:
3070:
3066:
3063:
3061:
3058:
3056:
3053:
3052:
3051:
3050:
3046:
3044:
3041:
3040:
3033:
3030:
3028:
3025:
3023:
3020:
3018:
3015:
3013:
3010:
3008:
3005:
3003:
3000:
2998:
2995:
2994:
2993:
2990:
2988:
2985:
2983:
2980:
2976:
2973:
2971:
2968:
2967:
2966:
2963:
2961:
2958:
2956:
2953:
2951:
2948:
2947:
2946:
2943:
2942:
2940:
2938:
2927:
2921:
2918:
2914:
2911:
2909:
2906:
2904:
2901:
2900:
2899:
2896:
2892:
2889:
2887:
2884:
2882:
2879:
2877:
2874:
2872:
2869:
2867:
2864:
2863:
2862:
2859:
2858:
2856:
2854:
2847:
2837:
2834:
2832:
2829:
2828:
2826:
2823:
2818:
2812:
2809:
2808:
2806:
2803:
2798:
2792:
2789:
2787:
2784:
2783:
2781:
2778:
2773:
2765:
2762:
2760:
2757:
2755:
2752:
2751:
2750:
2747:
2746:
2744:
2741:
2736:
2728:
2725:
2723:
2720:
2718:
2715:
2714:
2713:
2710:
2706:
2703:
2701:
2698:
2696:
2693:
2689:
2686:
2684:
2681:
2680:
2679:
2676:
2674:
2671:
2670:
2669:
2666:
2665:
2663:
2660:
2655:
2649:
2646:
2642:
2639:
2637:
2634:
2633:
2632:
2629:
2625:
2622:
2620:
2617:
2615:
2612:
2611:
2610:
2607:
2605:
2602:
2598:
2595:
2593:
2590:
2589:
2588:
2585:
2583:
2580:
2576:
2573:
2571:
2567:
2566:
2565:
2562:
2561:
2559:
2556:
2551:
2545:
2542:
2538:
2535:
2533:
2530:
2529:
2528:
2525:
2521:
2518:
2516:
2513:
2511:
2508:
2507:
2506:
2503:
2499:
2496:
2494:
2491:
2489:
2486:
2485:
2484:
2481:
2479:
2476:
2472:
2469:
2467:
2464:
2462:
2459:
2458:
2457:
2454:
2450:
2447:
2445:
2442:
2441:
2440:
2437:
2435:
2432:
2430:
2427:
2423:
2420:
2418:
2415:
2414:
2413:
2410:
2409:
2407:
2404:
2399:
2396:
2394:
2387:
2384:
2380:
2376:
2371:
2368:
2363:
2359:
2343:
2340:
2338:
2335:
2333:
2330:
2328:
2325:
2323:
2320:
2319:
2318:
2315:
2314:
2312:
2310:
2306:
2298:
2295:
2293:
2290:
2288:
2285:
2283:
2280:
2278:
2275:
2273:
2270:
2268:
2265:
2264:
2263:
2260:
2259:
2257:
2255:
2251:
2242:
2239:
2235:
2232:
2230:
2227:
2226:
2225:
2222:
2218:
2215:
2213:
2210:
2208:
2205:
2203:
2200:
2198:
2195:
2194:
2193:
2190:
2189:
2188:
2185:
2181:
2178:
2176:
2173:
2171:
2168:
2166:
2163:
2162:
2161:
2158:
2157:
2155:
2153:
2149:
2143:
2140:
2136:
2133:
2131:
2128:
2127:
2126:
2123:
2121:
2118:
2116:
2113:
2111:
2108:
2106:
2103:
2101:
2098:
2096:
2093:
2089:
2086:
2084:
2081:
2080:
2079:
2076:
2074:
2071:
2070:
2068:
2066:
2063:
2059:
2049:
2046:
2045:
2043:
2035:
2027:
2024:
2022:
2019:
2017:
2014:
2013:
2012:
2009:
2005:
2002:
2000:
1997:
1995:
1992:
1990:
1987:
1985:
1982:
1980:
1977:
1975:
1972:
1971:
1970:
1967:
1966:
1964:
1958:
1950:
1947:
1945:
1942:
1940:
1937:
1935:
1932:
1931:
1930:
1927:
1925:
1922:
1918:
1915:
1913:
1910:
1908:
1905:
1904:
1903:
1900:
1899:
1897:
1891:
1883:
1880:
1878:
1875:
1874:
1873:
1870:
1866:
1863:
1861:
1858:
1856:
1853:
1851:
1848:
1847:
1846:
1843:
1839:
1836:
1834:
1831:
1829:
1826:
1825:
1823:
1819:
1816:
1814:
1811:
1809:
1806:
1805:
1804:
1801:
1799:
1796:
1792:
1789:
1787:
1784:
1783:
1782:
1779:
1777:
1774:
1772:
1769:
1768:
1766:
1763:
1755:
1749:
1746:
1744:
1741:
1737:
1734:
1732:
1729:
1727:
1724:
1723:
1722:
1719:
1717:
1714:
1713:
1711:
1705:
1699:
1696:
1690:
1687:
1685:
1682:
1681:
1680:
1677:
1675:
1672:
1671:
1670:
1667:
1663:
1660:
1658:
1655:
1654:
1653:
1650:
1646:
1643:
1641:
1638:
1637:
1636:
1633:
1629:
1626:
1624:
1621:
1619:
1616:
1615:
1614:
1611:
1607:
1604:
1602:
1599:
1598:
1597:
1594:
1590:
1587:
1585:
1582:
1580:
1577:
1575:
1572:
1571:
1570:
1567:
1565:
1562:
1558:
1555:
1553:
1550:
1549:
1548:
1545:
1543:
1540:
1536:
1533:
1531:
1528:
1527:
1526:
1523:
1522:
1520:
1514:
1511:
1508:
1504:
1500:
1494:
1491:
1487:
1484:
1482:
1479:
1477:
1474:
1473:
1472:
1469:
1467:
1464:
1462:
1459:
1455:
1452:
1450:
1447:
1445:
1442:
1440:
1437:
1436:
1435:
1432:
1428:
1425:
1423:
1420:
1418:
1415:
1413:
1410:
1409:
1408:
1405:
1403:
1400:
1398:
1395:
1393:
1390:
1388:
1385:
1383:
1380:
1378:
1375:
1371:
1368:
1366:
1363:
1361:
1358:
1357:
1356:
1353:
1349:
1346:
1344:
1341:
1339:
1336:
1334:
1331:
1329:
1326:
1324:
1321:
1320:
1319:
1316:
1314:
1311:
1309:
1306:
1302:
1299:
1297:
1294:
1293:
1292:
1289:
1285:
1282:
1280:
1277:
1275:
1272:
1270:
1267:
1265:
1262:
1260:
1257:
1255:
1252:
1250:
1247:
1246:
1245:
1242:
1238:
1235:
1233:
1230:
1228:
1225:
1223:
1220:
1218:
1215:
1213:
1210:
1208:
1205:
1203:
1200:
1199:
1198:
1195:
1194:
1192:
1189:
1185:
1182:
1178:
1174:
1170:
1165:
1161:
1157:
1153:
1146:
1141:
1139:
1134:
1132:
1127:
1126:
1123:
1116:
1112:
1109:
1108:
1104:
1095:
1091:
1086:
1081:
1077:
1073:
1069:
1065:
1061:
1054:
1051:
1046:
1042:
1038:
1034:
1030:
1026:
1022:
1018:
1014:
1010:
1006:
999:
997:
993:
988:
984:
979:
974:
970:
966:
962:
955:
952:
947:
943:
938:
933:
929:
925:
921:
914:
912:
908:
903:
899:
894:
889:
884:
879:
875:
871:
867:
860:
858:
854:
849:
845:
840:
835:
831:
827:
823:
819:
815:
811:
807:
800:
797:
792:
788:
783:
778:
774:
770:
767:(2): 333–50.
766:
762:
758:
751:
748:
743:
739:
734:
729:
724:
719:
716:(9): 908–19.
715:
711:
707:
700:
697:
692:
686:
682:
678:
674:
667:
664:
659:
655:
651:
647:
643:
639:
635:
631:
624:
621:
615:
610:
606:
602:
598:
591:
588:
583:
579:
575:
571:
567:
563:
556:
553:
548:
542:
538:
534:
530:
523:
520:
515:
511:
506:
501:
497:
493:
489:
482:
480:
476:
471:
467:
463:
459:
455:
451:
447:
443:
436:
433:
428:
424:
420:
416:
412:
408:
404:
400:
396:
392:
385:
383:
379:
373:
367:
362:
361:
352:
349:
342:
340:
338:
334:
329:
327:
323:
319:
315:
310:
308:
304:
300:
296:
291:
289:
285:
281:
277:
272:
270:
262:
260:
258:
254:
250:
246:
242:
238:
230:
228:
226:
222:
217:
215:
210:
206:
202:
198:
190:
188:
186:
180:
176:
173:
169:
165:
160:
158:
154:
150:
145:
141:
137:
128:
121:
119:
117:
112:
108:
104:
101:
97:
92:
90:
85:
81:
77:
73:
69:
65:
61:
53:
52:alpha helices
49:
45:
41:
37:
36:helical wheel
32:
19:
6552:
6507:
6463:
6421:
6413:
6385:
6379:
6373:
6342:
6307:
6295:
6232:
6209:
6191:
6159:
6130:
6011:
5941:
5915:
5867:
5770:
5717:
5637:
5625:
5579:
5571:
5477:
5423:
5396:
5388:
5359:
5348:
5092:FOX proteins
5052:winged helix
5044:
5015:
4998:
4941:
4861:
4835:
4713:
4679:
4662:
4640:
4623:
4556:
4524:
4378:
4341:
4322:
4268:
4234:
4228:
3922:
3916:
3905:
3899:Antennapedia
3897:
3884:
3872:
3866:
3835:
3793:
3771:
3748:
3727:
3485:
3438:
3384:
3330:
3243:
3221:
3199:
3177:
3160:
3118:
3047:
2929:
2897:
2849:
2821:
2801:
2776:
2739:
2705:Progesterone
2658:
2554:
2402:
2388:
2382:
2366:
2308:
2261:
2253:
2151:
2061:
2010:
1968:
1928:
1901:
1871:
1844:
1678:
1668:
1651:
1634:
1546:
1502:
1470:
1433:
1290:
1183:
1180:
1168:
1067:
1063:
1053:
1012:
1008:
968:
964:
954:
927:
923:
873:
869:
813:
809:
799:
764:
760:
750:
713:
709:
699:
672:
666:
636:(2): 170–6.
633:
629:
623:
604:
600:
590:
565:
561:
555:
528:
522:
495:
491:
445:
441:
435:
394:
390:
359:
351:
330:
317:
313:
311:
292:
287:
275:
273:
266:
234:
218:
209:major groove
194:
181:
177:
164:coiled coils
161:
136:dimerization
133:
93:
63:
59:
57:
39:
18:Basic zipper
6233:(4.11) Runt
3888:Homeodomain
3486:zinc finger
2822:subfamily 0
2802:subfamily 6
2777:subfamily 5
2740:subfamily 4
2659:subfamily 3
2555:subfamily 2
2403:subfamily 1
2370:Zinc finger
1613:Neurogenins
1181:(1.1) Basic
1064:Discoveries
630:ChemBioChem
568:: 299–310.
214:specificity
157:hydrophilic
149:hydrophobic
144:amphipathic
107:amino acids
89:side chains
80:alpha helix
48:amino acids
42:represents
6569:Categories
4766:POU domain
3906:ANTP class
3836:(2.6) WRKY
3119:GLI family
2254:(1.5) RF-X
2152:(1.4) NF-1
1070:(2): e15.
876:: e19272.
690:0470016175
546:0470016175
343:References
100:eukaryotic
6553:see also
6394:Apetala 2
5048:Fork head
3728:(2.4) Cys
2930:(2.3) Cys
1662:Scleraxis
1029:0092-8674
582:0091-7451
295:apoptotic
205:arginines
168:supercoil
5871:MADS box
4011:Homeobox
3923:Hox-like
3917:protoHOX
2678:Estrogen
2673:Androgen
2527:Rev-ErbA
2065:bHLH-ZIP
2040:bHLH-COE
1579:Myogenin
1094:26539561
946:16051676
902:28186491
848:23661758
791:18065552
742:18804028
658:39252601
650:14760737
514:24782137
140:monomers
6271:RUNX1T1
6251:CBFA2T3
6246:CBFA2T2
6126:TCF/LEF
4235:NK-like
4229:metaHOX
3932:ParaHox
3873:domains
2564:COUP-TF
2038:Group F
1961:Group E
1894:Group D
1758:Group C
1708:Group B
1652:Paraxis
1517:Group A
1085:4629104
1045:5068895
1037:3141060
987:8940135
893:5349851
839:4115154
818:Bibcode
810:Science
782:2245831
733:7111190
470:2683088
450:Bibcode
442:Science
419:3289117
399:Bibcode
391:Science
231:Biology
201:lysines
153:solvent
84:leucine
44:leucine
4984:Bicoid
4249:BARHL2
4244:BARHL1
3826:JMJD1B
3739:HIVEP1
2224:I-SMAD
2192:R-SMAD
2110:MLXIPL
1865:Period
1791:ARNTL2
1596:NeuroD
1117:(MeSH)
1092:
1082:
1043:
1035:
1027:
985:
944:
900:
890:
846:
836:
789:
779:
740:
730:
687:
656:
648:
580:
543:
512:
468:
425:
417:
368:
257:cancer
251:, and
155:. The
6534:Sigma
6399:EREBP
6383:EREBP
6374:(0.5)
6343:(0.3)
6266:RUNX3
6261:RUNX2
6256:RUNX1
6200:TFCP2
6121:SSRP1
5942:(4.7)
5932:TBPL1
5916:(4.6)
5868:(4.4)
5718:(4.2)
5659:NFKB2
5654:NFKB1
5649:NF-ÎşB
5638:(4.1)
5562:MYBL2
5349:(3.4)
5045:(3.3)
4994:BICD2
4969:SHOX2
4937:PROP1
4921:PRRX
4831:SATB2
4776:BRN-3
4771:PIT-1
4663:PKNOX
4578:TALE
4574:NOBOX
4547:HESX1
4520:CUTL1
4502:other
4396:NANOG
4259:BARX2
4254:BARX1
4006:MEOX2
4001:MEOX1
3885:(3.1)
3794:JARID
3767:GRLF1
3762:DIDO1
3422:Zbtb7
3412:TSHZ3
3380:PRDM9
3178:HIVEP
3043:ATBF1
2997:TFIIH
2982:TFIIF
2965:TFIIE
2960:TFIID
2955:TFIIB
2950:TFIIA
2920:TRPS1
2786:LRH-1
2764:NURR1
2754:NGFIB
2582:Ear-2
2383:(2.1)
2125:SREBP
2062:(1.3)
1824:NPAS
1813:EPAS1
1798:CLOCK
1786:ARNTL
1760:bHLH-
1736:n-Myc
1731:l-Myc
1726:c-Myc
1716:FIGLA
1698:Twist
1657:TCF15
1564:MESP2
1542:ATOH1
1535:ASCL2
1530:ASCL1
1461:NFIL3
1392:GABPA
1387:DDIT3
1318:C/EBP
1313:BLZF1
1274:c-Jun
1264:FOSL2
1259:FOSL1
1249:c-Fos
1041:S2CID
870:eLife
654:S2CID
427:42512
423:S2CID
318:Nfil3
314:Nfil3
307:FOXO1
303:TRAIL
299:HDAC2
288:Nfil3
276:Nfil3
269:NFIL3
241:c-jun
237:c-fos
6503:MNDA
6422:ARID
6377:AP-2
6364:RBL2
6359:RBL1
6333:HBP1
6316:HMGA
6223:YBX1
6218:CSDA
6153:LEF1
5985:HMGN
5958:HMGB
5879:Mef2
5858:MYRF
5846:TBR2
5841:TBR1
5789:TP63
5729:STAT
5721:STAT
5681:NFAT
5674:RELB
5669:RELA
5624:(4)
5505:FLI1
5471:SPIB
5172:D4L6
5167:D4L5
5162:D4L4
5157:D4L3
5152:D4L1
5016:PITX
4979:VSX2
4974:VSX1
4964:SHOX
4942:PHOX
4624:MEIS
4552:HOPX
4488:VAX2
4483:VAX1
4478:TLX3
4473:TLX2
4468:TLX1
4463:NATO
4446:HMX3
4441:HMX2
4436:HMX1
4374:LBX2
4369:LBX1
4359:HHEX
4218:MNX1
4213:GBX2
4208:GBX1
3996:Evx2
3991:Evx1
3959:PDX1
3954:Xlox
3844:WRKY
3757:AIRE
3716:804A
3439:ZBTB
3385:SALL
3375:OSR1
3370:MYT1
3365:MTF1
3200:IKZF
3139:REST
3114:GFI1
3109:ERV3
3077:E4F1
3072:CTCF
2861:GATA
2831:DAX1
2811:GCNF
2759:NOR1
2587:HNF4
2456:PPAR
2389:(Cys
2317:AP-2
2187:SMAD
2142:USF1
2115:MXI1
2095:MITF
2088:MXD3
2083:MXD1
2073:AP-4
2048:EBF1
1924:Pho4
1902:BHLH
1781:ARNT
1776:AHRR
1748:TCF4
1743:MXD4
1674:LYL1
1635:OLIG
1589:MYF6
1584:MYF5
1574:MyoD
1547:HAND
1525:AS-C
1507:bHLH
1493:XBP1
1397:GCN4
1377:CREM
1355:CREB
1308:BATF
1291:BACH
1284:JunD
1279:JUNB
1269:JDP2
1254:FOSB
1244:AP-1
1202:AATF
1188:bZIP
1154:and
1090:PMID
1033:PMID
1025:ISSN
1009:Cell
983:PMID
942:PMID
898:PMID
844:PMID
787:PMID
738:PMID
685:ISBN
646:PMID
578:ISSN
541:ISBN
510:PMID
466:PMID
415:PMID
366:ISBN
326:CEBP
322:CREB
253:mxd1
239:and
203:and
96:bZIP
62:(or
6530:Rho
6508:NFY
6481:MLL
6464:IFI
6459:CAP
6241:CBF
6160:TOX
6131:TCF
6116:SRY
6029:SOX
6012:HNF
5953:BBX
5927:TBP
5906:SRF
5851:TFT
5801:TBX
5794:p73
5784:p53
5664:REL
5557:MYB
5478:ETV
5466:ERG
5451:ETS
5446:ERF
5424:ELK
5419:EGF
5397:ELF
5361:HSF
5060:E2F
4999:OTX
4989:GSC
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