297:
274:
171:
196:
303:
202:
2132:
1256:
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P,
1045:
in order to enhance programmed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK.
1161:
Boyd JM, Gallo GJ, Elangovan B, Houghton AB, Malstrom S, Avery BJ, Ebb RG, Subramanian T, Chittenden T, Lutz RJ (Dec 1995). "Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins".
50:
1189:
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999).
1257:
Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".
1852:
Federici M, Hribal M, Perego L, Ranalli M, Caradonna Z, Perego C, Usellini L, Nano R, Bonini P, Bertuzzi F, Marlier LN, Davalli AM, Carandente O, Pontiroli AE, Melino G, Marchetti P, Lauro R, Sesti G, Folli F (2001).
1788:
Verma S, Budarf ML, Emanuel BS, Chinnadurai G (2000). "Structural analysis of the human pro-apoptotic gene Bik: chromosomal localization, genomic organization and localization of promoter sequences".
1855:"High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program"
310:
209:
1564:"harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)"
752:
733:
132:
1685:"A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region"
2201:
2077:
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, Goward ME, Aguado B, Mallya M, Mokrab Y, Huckle EJ, Beare DM, Dunham I (2005).
2177:
2196:
1143:
47:
1125:
296:
956:
963:
273:
1720:"Survival activity of Bcl-2 homologs Bcl-w and A1 only partially correlates with their ability to bind pro-apoptotic family members"
1449:
1242:
1112:
1091:
1987:
Arena V, Martini M, Luongo M, Capelli A, Larocca LM (2003). "Mutations of the BIK gene in human peripheral B-cell lymphomas".
1946:"Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway"
1357:"Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway"
2026:"The Bik BH3-only protein is induced in estrogen-starved and antiestrogen-exposed breast cancer cells and provokes apoptosis"
1607:"The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4"
195:
170:
1108:
1888:
Zou Y, Peng H, Zhou B, Wen Y, Wang SC, Tsai EM, Hung MC (2002). "Systemic tumor suppression by the proapoptotic gene bik".
1455:
1087:
1313:"Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function"
112:
1055:
2170:
1037:
The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as
309:
208:
1311:
Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC (February 2005).
1755:"Mapping of a target region of allelic loss to a 0.5-cM interval on chromosome 22q13 in human colorectal cancer"
302:
201:
797:
120:
1355:
Gillissen B, Essmann F, Graupner V, Stärck L, Radetzki S, Dörken B, Schulze-Osthoff K, Daniel PT (July 2003).
778:
1042:
1911:"BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria"
1944:
Gillissen B, Essmann F, Graupner V, Stärck L, Radetzki S, Dörken B, Schulze-Osthoff K, Daniel PT (2003).
1819:"Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis"
1478:"A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions"
1406:"Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis"
2163:
184:
1476:
Chittenden T, Flemington C, Houghton AB, Ebb RG, Gallo GJ, Elangovan B, Chinnadurai G, Lutz RJ (1996).
2037:
1650:"Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist"
1266:
1203:
99:
1461:
918:
2012:
1290:
1059:
144:
939:
914:
888:
867:
1521:"Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K"
2110:
2065:
2004:
1975:
1932:
1897:
1876:
1840:
1805:
1776:
1741:
1706:
1671:
1636:
1593:
1550:
1507:
1427:
1386:
1334:
1282:
1221:
1171:
92:
40:
2147:
2100:
2090:
2055:
2045:
1996:
1965:
1957:
1922:
1866:
1830:
1797:
1766:
1731:
1696:
1661:
1626:
1618:
1583:
1575:
1540:
1532:
1497:
1489:
1417:
1376:
1368:
1324:
1274:
1211:
389:
320:
264:
219:
1683:
Ohi N, Tokunaga A, Tsunoda H, Nakano K, Haraguchi K, Oda K, Motoyama N, Nakajima T (1999).
364:
140:
2041:
1270:
1207:
1631:
1606:
1588:
1563:
1493:
2105:
2078:
2060:
2025:
1970:
1945:
1801:
1771:
1754:
1545:
1520:
1502:
1477:
1381:
1356:
667:
662:
657:
652:
647:
642:
626:
621:
616:
611:
606:
590:
585:
580:
2190:
2143:
567:
2016:
124:
1294:
382:
161:
1835:
1818:
1422:
1405:
1329:
1312:
148:
1148:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1130:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1871:
1854:
465:
1622:
1579:
281:
178:
128:
2095:
2024:
Hur J, Chesnes J, Coser KR, Lee RS, Geck P, Isselbacher KJ, Shioda T (2004).
2050:
1666:
1649:
697:
525:
403:
348:
335:
247:
234:
136:
2114:
2069:
2008:
1979:
1961:
1936:
1927:
1910:
1901:
1880:
1844:
1809:
1780:
1745:
1736:
1719:
1710:
1701:
1684:
1536:
1431:
1390:
1372:
1338:
1286:
1225:
1675:
1648:
Hegde R, Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES (1998).
1640:
1597:
1554:
1511:
1175:
1003:
998:
987:
842:
823:
1278:
1019:
809:
764:
2000:
69:
1753:
Castells A, Ino Y, Louis DN, Ramesh V, Gusella JF, Rustgi AK (1999).
971:
719:
2131:
1216:
1191:
2079:"A genome annotation-driven approach to cloning the human ORFeome"
1063:
1038:
682:
678:
2139:
1026:
653:
positive regulation of release of cytochrome c from mitochondria
116:
1243:"Entrez Gene: BIK BCL2-interacting killer (apoptosis-inducing)"
372:
2151:
537:
932:
907:
881:
860:
1104:
1102:
1100:
1083:
1081:
1079:
648:positive regulation of protein homooligomerization
1718:Holmgreen SP, Huang DC, Adams JM, Cory S (1999).
319:
218:
1350:
1348:
16:Protein-coding gene in the species Homo sapiens
1306:
1304:
1109:GRCm38: Ensembl release 89: ENSMUSG00000016758
2171:
8:
1562:Inohara N, Ding L, Chen S, Núñez G (1997).
1088:GRCh38: Ensembl release 89: ENSG00000100290
1054:Bcl-2-interacting killer has been shown to
2178:
2164:
693:
563:
504:transitional epithelium of urinary bladder
360:
259:
156:
58:
2104:
2094:
2059:
2049:
1969:
1926:
1870:
1834:
1770:
1735:
1700:
1665:
1630:
1587:
1544:
1501:
1421:
1380:
1328:
1215:
1192:"The DNA sequence of human chromosome 22"
103:, BIP1, BP4, NBK, BCL2 interacting killer
1237:
1235:
1909:Germain M, Mathai JP, Shore GC (2002).
1075:
18:
324:
285:
280:
223:
182:
177:
7:
2128:
2126:
1519:Han J, Sabbatini P, White E (1996).
1605:Huang DC, Adams JM, Cory S (1998).
591:protein heterodimerization activity
2150:. You can help Knowledge (XXG) by
1494:10.1002/j.1460-2075.1995.tb00246.x
929:
904:
878:
857:
833:
814:
788:
769:
743:
724:
542:
460:
398:
377:
14:
1022:that in humans is encoded by the
2130:
512:lumbar subsegment of spinal cord
308:
301:
295:
272:
207:
200:
194:
169:
668:apoptotic mitochondrial changes
643:regulation of apoptotic process
2202:Human chromosome 22 gene stubs
1404:Jiang A, Clark EA (May 2001).
607:integral component of membrane
526:More reference expression data
418:olfactory zone of nasal mucosa
1:
1802:10.1016/S0378-1119(00)00276-6
1772:10.1016/S0016-5085(99)70341-0
293:
192:
2197:Genes on human chromosome 22
2030:Proc. Natl. Acad. Sci. U.S.A
1836:10.4049/jimmunol.166.10.6025
1423:10.4049/jimmunol.166.10.6025
1330:10.1016/j.molcel.2004.12.030
2218:
2125:
1872:10.2337/diabetes.50.6.1290
1817:Jiang A, Clark EA (2001).
1460:gene details page in the
426:mucosa of transverse colon
1144:"Mouse PubMed Reference:"
1126:"Human PubMed Reference:"
1002:
997:
993:
986:
970:
951:
936:
911:
900:
885:
864:
853:
840:
836:
821:
817:
808:
795:
791:
776:
772:
763:
750:
746:
731:
727:
718:
703:
696:
692:
676:
566:
562:
550:
545:
536:
523:
472:
463:
450:mucosa of paranasal sinus
438:bronchial epithelial cell
410:
401:
371:
363:
359:
342:
329:
292:
271:
262:
258:
241:
228:
191:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
2096:10.1186/gb-2004-5-10-r84
1989:Genes Chromosomes Cancer
1016:Bcl-2-interacting killer
964:Chr 15: 83.41 – 83.43 Mb
957:Chr 22: 43.11 – 43.13 Mb
2051:10.1073/pnas.0307337101
1667:10.1074/jbc.273.14.7783
1623:10.1093/emboj/17.4.1029
1580:10.1093/emboj/16.7.1686
617:mitochondrial membranes
442:mucosa of sigmoid colon
1928:10.1074/jbc.M201235200
1737:10.1038/sj.cdd.4400519
1702:10.1038/sj.cdd.4400493
1537:10.1128/MCB.16.10.5857
663:male gonad development
480:lumbar spinal ganglion
434:epithelium of bronchus
446:minor salivary glands
422:palpebral conjunctiva
287:Chromosome 15 (mouse)
185:Chromosome 22 (human)
1962:10.1093/emboj/cdg343
1454:genome location and
1373:10.1093/emboj/cdg343
62:List of PDB id codes
35:Available structures
2042:2004PNAS..101.2351H
1462:UCSC Genome Browser
1279:10.1038/nature04209
1271:2005Natur.437.1173R
1208:1999Natur.402..489D
612:endomembrane system
492:conjunctival fornix
2138:This article on a
1043:Epstein–Barr virus
798:ENSMUSG00000016758
636:Biological process
600:Cellular component
574:Molecular function
2159:
2158:
2001:10.1002/gcc.10245
1724:Cell Death Differ
1689:Cell Death Differ
1013:
1012:
1009:
1008:
982:
981:
947:
946:
926:
925:
896:
895:
875:
874:
849:
848:
830:
829:
804:
803:
785:
784:
759:
758:
740:
739:
688:
687:
658:apoptotic process
586:BH domain binding
558:
557:
554:
553:
532:
531:
519:
518:
457:
456:
355:
354:
254:
253:
81:
80:
77:
76:
45:Ortholog search:
2209:
2180:
2173:
2166:
2134:
2127:
2118:
2108:
2098:
2073:
2063:
2053:
2020:
1983:
1973:
1940:
1930:
1921:(20): 18053–60.
1905:
1884:
1874:
1848:
1838:
1813:
1784:
1774:
1759:Gastroenterology
1749:
1739:
1714:
1704:
1679:
1669:
1644:
1634:
1601:
1591:
1558:
1548:
1515:
1505:
1436:
1435:
1425:
1401:
1395:
1394:
1384:
1352:
1343:
1342:
1332:
1308:
1299:
1298:
1265:(7062): 1173–8.
1253:
1247:
1246:
1239:
1230:
1229:
1219:
1202:(6761): 489–95.
1186:
1180:
1179:
1158:
1152:
1151:
1140:
1134:
1133:
1122:
1116:
1106:
1095:
1085:
995:
994:
966:
959:
942:
930:
921:
905:
901:RefSeq (protein)
891:
879:
870:
858:
834:
815:
789:
770:
744:
725:
694:
564:
543:
528:
468:
466:Top expressed in
461:
414:nasal epithelium
406:
404:Top expressed in
399:
378:
361:
351:
338:
327:
312:
305:
299:
288:
276:
260:
250:
237:
226:
211:
204:
198:
187:
173:
157:
151:
102:
95:
72:
59:
53:
32:
31:
19:
2217:
2216:
2212:
2211:
2210:
2208:
2207:
2206:
2187:
2186:
2185:
2184:
2123:
2121:
2076:
2023:
1986:
1956:(14): 3580–90.
1943:
1908:
1887:
1865:(6): 1290–301.
1851:
1829:(10): 6025–33.
1816:
1796:(1–2): 157–62.
1787:
1752:
1717:
1682:
1647:
1604:
1561:
1531:(10): 5857–64.
1525:Mol. Cell. Biol
1518:
1488:(22): 5589–96.
1475:
1471:
1469:Further reading
1445:
1440:
1439:
1416:(10): 6025–33.
1403:
1402:
1398:
1367:(14): 3580–90.
1354:
1353:
1346:
1310:
1309:
1302:
1255:
1254:
1250:
1241:
1240:
1233:
1188:
1187:
1183:
1160:
1159:
1155:
1142:
1141:
1137:
1124:
1123:
1119:
1107:
1098:
1086:
1077:
1072:
1052:
1035:
1004:View/Edit Mouse
999:View/Edit Human
962:
955:
952:Location (UCSC)
938:
917:
913:
887:
866:
779:ENSG00000100290
672:
631:
595:
581:protein binding
524:
515:
510:
508:right lung lobe
506:
502:
498:
494:
490:
486:
484:proximal tubule
482:
478:
464:
453:
448:
444:
440:
436:
432:
428:
424:
420:
416:
402:
346:
333:
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
213:
212:
205:
183:
160:Gene location (
149:BIK - orthologs
111:
98:
91:
68:
46:
17:
12:
11:
5:
2215:
2213:
2205:
2204:
2199:
2189:
2188:
2183:
2182:
2175:
2168:
2160:
2157:
2156:
2135:
2120:
2119:
2074:
2021:
1984:
1941:
1906:
1885:
1849:
1814:
1785:
1750:
1715:
1680:
1660:(14): 7783–6.
1645:
1617:(4): 1029–39.
1602:
1574:(7): 1686–94.
1559:
1516:
1472:
1470:
1467:
1466:
1465:
1444:
1443:External links
1441:
1438:
1437:
1396:
1344:
1323:(3): 393–403.
1300:
1248:
1231:
1217:10.1038/990031
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496:primary oocyte
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365:RNA expression
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28:
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15:
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10:
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6:
4:
3:
2:
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2200:
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2192:
2181:
2176:
2174:
2169:
2167:
2162:
2161:
2155:
2153:
2149:
2145:
2144:chromosome 22
2141:
2136:
2133:
2129:
2124:
2116:
2112:
2107:
2102:
2097:
2092:
2088:
2084:
2080:
2075:
2071:
2067:
2062:
2057:
2052:
2047:
2043:
2039:
2036:(8): 2351–6.
2035:
2031:
2027:
2022:
2018:
2014:
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2006:
2002:
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1994:
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1981:
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1934:
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1924:
1920:
1916:
1915:J. Biol. Chem
1912:
1907:
1903:
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1891:
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1778:
1773:
1768:
1764:
1760:
1756:
1751:
1747:
1743:
1738:
1733:
1730:(6): 525–32.
1729:
1725:
1721:
1716:
1712:
1708:
1703:
1698:
1695:(4): 314–25.
1694:
1690:
1686:
1681:
1677:
1673:
1668:
1663:
1659:
1655:
1654:J. Biol. Chem
1651:
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1218:
1213:
1209:
1205:
1201:
1197:
1193:
1185:
1182:
1177:
1173:
1170:(9): 1921–8.
1169:
1165:
1157:
1154:
1149:
1145:
1139:
1136:
1131:
1127:
1121:
1118:
1114:
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1101:
1097:
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1057:
1049:
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1028:
1025:
1021:
1017:
1005:
1000:
996:
992:
989:
985:
978:
976:
973:
969:
965:
961:
958:
954:
950:
943:
941:
935:
931:
928:
922:
920:
916:
910:
906:
903:
899:
892:
890:
884:
880:
877:
871:
869:
863:
859:
856:
854:RefSeq (mRNA)
852:
845:
844:
839:
835:
832:
826:
825:
820:
816:
813:
811:
807:
800:
799:
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790:
787:
781:
780:
775:
771:
768:
766:
762:
755:
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749:
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742:
736:
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730:
726:
723:
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684:
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641:
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638:
635:
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628:
625:
623:
622:mitochondrion
620:
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610:
608:
605:
604:
602:
599:
598:
592:
589:
587:
584:
582:
579:
578:
576:
573:
572:
569:
568:Gene ontology
565:
561:
549:
544:
541:
539:
535:
527:
522:
511:
507:
503:
499:
495:
491:
487:
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341:
337:
332:
326:15|15 E1
322:
318:
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291:
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279:
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257:
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197:
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138:
134:
130:
126:
122:
118:
114:
106:
101:
94:
89:
84:
73:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
2152:expanding it
2137:
2122:
2086:
2082:
2033:
2029:
1992:
1988:
1953:
1949:
1918:
1914:
1893:
1889:
1862:
1858:
1826:
1822:
1793:
1789:
1765:(4): 831–7.
1762:
1758:
1727:
1723:
1692:
1688:
1657:
1653:
1614:
1610:
1571:
1567:
1528:
1524:
1485:
1481:
1456:
1450:
1413:
1409:
1399:
1364:
1360:
1320:
1316:
1262:
1258:
1251:
1199:
1195:
1184:
1167:
1163:
1156:
1147:
1138:
1129:
1120:
1053:
1050:Interactions
1036:
1023:
1015:
1014:
937:
912:
886:
865:
841:
822:
796:
777:
751:
732:
712:
707:
476:right kidney
388:
381:
108:External IDs
67:
2089:(10): R84.
2083:Genome Biol
1995:(1): 91–6.
1896:(1): 8–12.
1060:BCL2-like 1
919:NP_001188.1
347:83,428,835
334:83,411,063
246:43,129,712
233:43,110,750
86:Identifiers
2191:Categories
1890:Cancer Res
1823:J. Immunol
1410:J. Immunol
1115:, May 2017
1094:, May 2017
1070:References
392:(ortholog)
129:HomoloGene
2142:on human
1317:Mol. Cell
940:NP_031572
915:NP_001188
889:NM_007546
868:NM_001197
698:Orthologs
137:GeneCards
2115:15461802
2070:14983013
2017:23761640
2009:12874789
1980:12853473
1937:11884414
1902:11782349
1881:11375329
1859:Diabetes
1845:11342619
1810:10974546
1781:10500065
1746:10381646
1711:10381623
1432:11342619
1391:12853473
1339:15694340
1287:16189514
1226:10591208
1164:Oncogene
1111:–
1090:–
1056:interact
1041:and the
1033:Function
988:Wikidata
677:Sources:
627:membrane
2038:Bibcode
1676:9525867
1641:9463381
1632:1170452
1598:9130713
1589:1169772
1555:8816500
1512:8521816
1295:4427026
1267:Bibcode
1204:Bibcode
1176:7478623
1113:Ensembl
1092:Ensembl
1020:protein
810:UniProt
765:Ensembl
704:Species
683:QuickGO
367:pattern
225:22q13.2
125:1206591
93:Aliases
2113:
2106:545604
2103:
2068:
2061:356954
2058:
2015:
2007:
1978:
1971:165613
1968:
1950:EMBO J
1935:
1900:
1879:
1843:
1808:
1779:
1744:
1709:
1674:
1639:
1629:
1611:EMBO J
1596:
1586:
1568:EMBO J
1553:
1546:231587
1543:
1510:
1503:394673
1500:
1482:EMBO J
1448:Human
1430:
1389:
1382:165613
1379:
1361:EMBO J
1337:
1293:
1285:
1259:Nature
1224:
1196:Nature
1174:
974:search
972:PubMed
843:O70337
824:Q13323
720:Entrez
538:BioGPS
500:zygote
488:embryo
117:603392
2146:is a
2013:S2CID
1291:S2CID
1064:Bcl-2
1058:with
1018:is a
753:12124
713:Mouse
708:Human
679:Amigo
430:gonad
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
162:Human
2148:stub
2140:gene
2111:PMID
2066:PMID
2005:PMID
1976:PMID
1933:PMID
1898:PMID
1877:PMID
1841:PMID
1806:PMID
1790:Gene
1777:PMID
1742:PMID
1707:PMID
1672:PMID
1637:PMID
1594:PMID
1551:PMID
1508:PMID
1428:PMID
1387:PMID
1335:PMID
1283:PMID
1222:PMID
1172:PMID
1062:and
1039:BCL2
1027:gene
373:Bgee
321:Band
282:Chr.
220:Band
179:Chr.
113:OMIM
70:2IPE
51:RCSB
48:PDBe
2101:PMC
2091:doi
2056:PMC
2046:doi
2034:101
1997:doi
1966:PMC
1958:doi
1923:doi
1919:277
1867:doi
1831:doi
1827:166
1798:doi
1794:254
1767:doi
1763:117
1732:doi
1697:doi
1662:doi
1658:273
1627:PMC
1619:doi
1584:PMC
1576:doi
1541:PMC
1533:doi
1498:PMC
1490:doi
1457:BIK
1451:BIK
1418:doi
1414:166
1377:PMC
1369:doi
1325:doi
1275:doi
1263:437
1212:doi
1200:402
1024:BIK
734:638
546:n/a
343:End
242:End
145:OMA
141:BIK
133:924
121:MGI
100:BIK
41:PDB
22:BIK
2193::
2109:.
2099:.
2085:.
2081:.
2064:.
2054:.
2044:.
2032:.
2028:.
2011:.
2003:.
1993:38
1991:.
1974:.
1964:.
1954:22
1952:.
1948:.
1931:.
1917:.
1913:.
1894:62
1892:.
1875:.
1863:50
1861:.
1857:.
1839:.
1825:.
1821:.
1804:.
1792:.
1775:.
1761:.
1757:.
1740:.
1726:.
1722:.
1705:.
1691:.
1687:.
1670:.
1656:.
1652:.
1635:.
1625:.
1615:17
1613:.
1609:.
1592:.
1582:.
1572:16
1570:.
1566:.
1549:.
1539:.
1529:16
1527:.
1523:.
1506:.
1496:.
1486:14
1484:.
1480:.
1426:.
1412:.
1408:.
1385:.
1375:.
1365:22
1363:.
1359:.
1347:^
1333:.
1321:17
1319:.
1315:.
1303:^
1289:.
1281:.
1273:.
1261:.
1234:^
1220:.
1210:.
1198:.
1194:.
1168:11
1166:.
1146:.
1128:.
1099:^
1078:^
1066:.
1029:.
681:/
349:bp
336:bp
248:bp
235:bp
143:;
139::
135:;
131::
127:;
123::
119:;
115::
2179:e
2172:t
2165:v
2154:.
2117:.
2093::
2087:5
2072:.
2048::
2040::
2019:.
1999::
1982:.
1960::
1939:.
1925::
1904:.
1883:.
1869::
1847:.
1833::
1812:.
1800::
1783:.
1769::
1748:.
1734::
1728:6
1713:.
1699::
1693:6
1678:.
1664::
1643:.
1621::
1600:.
1578::
1557:.
1535::
1514:.
1492::
1464:.
1434:.
1420::
1393:.
1371::
1341:.
1327::
1297:.
1277::
1269::
1245:.
1228:.
1214::
1206::
1178:.
1150:.
1132:.
267:)
164:)
147::
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