168:
133:
43:
443:
545:
463:
282:
642:
248:
Although they are most commonly found on people in their first two decades of life, the age range for people with Spitz nevi is from 6 months to 71 years, with a
538:
531:
848:
762:
622:
287:
767:
713:
167:
368:
343:
155:, however a minority (25%) of cells have been shown to contain extra copies of parts of some chromosomes, such as the short arm of
401:
Ries LAG, et al., eds. SEER Cancer
Statistics Review, 1975–2000. Bethesda, MD: National Cancer Institute; 2003: Tables XVI-1-9.
579:
753:
683:
277:
207:
151:, but causation is not established. Genetic studies of Spitz nevi have shown that most cells have the normal number of
605:
790:
813:
600:
471:
231:
187:, Spitz nevi characteristically have vertically arranged nests of nevus cells that have both a spindled and an
176:
823:
196:
853:
728:
723:
203:
172:
757:
733:
617:
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139:
of a Spitz nevus showing the characteristic vertically arranged nests of cells ("hanging bananas").
718:
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612:
781:
558:
211:
808:
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632:
482:
364:
339:
94:
55:
124:
is generally no longer used as it is neither a melanoma, nor does it occur only in children.
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584:
574:
132:
98:
315:
World Health
Organization Classification of Tumours: Pathology and Genetics of Skin Tumours
245:
in the same population, which is high by world standards is 25.4 cases per 100,000 people.
637:
596:
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249:
388:
Crotty, K. Spitz Naevus: Histological features and distinction from malignant melanoma.
17:
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90:
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673:
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265:
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188:
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and malignancy potential, including "Spitz, Reed or spindle nevus" at top right.
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to be 1.4 cases per 100,000 people. For comparison, the annual incidence of
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71:
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60:
435:
147:
The cause of Spitz nevi is not yet known. There is an association with
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148:
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253:
102:
87:
652:
131:
359:
Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007).
222:
Surgical removal is usually performed, even though it is benign.
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527:
334:
James, William D.; Berger, Timothy G.; et al. (2006).
268:, the pathologist who originally described it in 1948.
425:
283:
List of genes mutated in pigmented cutaneous lesions
651:
643:
Melanocytic tumors of uncertain malignant potential
565:
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429:
336:
70:
54:
35:
313:LeBoit, PE, Burg G, Weedon D, Sarasin A. (Eds)
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8:
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234:was estimated in a coastal population of
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623:Melanoma with features of a Spitz nevus
299:
288:Melanoma with features of a Spitz nevus
230:Spitz nevi are uncommon. Their annual
175:of pigmented skin lesions, by relative
363:. St. Louis: Mosby. pp. 1728–30.
309:
307:
305:
303:
7:
628:Melanoma with small nevus-like cells
390:Australasian Journal of Dermatology
110:epithelioid and spindle-cell nevus
25:
410:Spitz S. Melanomas of childhood.
849:Melanocytic nevi and neoplasms
580:Superficial spreading melanoma
1:
754:Congenital melanocytic nevus
684:Pigmented spindle cell nevus
392:. 38 (suppl): S49-S53. 1997.
278:List of cutaneous conditions
208:pigmented spindle cell nevus
870:
606:Acral lentiginous melanoma
264:The lesion is named after
799:
791:Dysplastic nevus syndrome
777:
749:
704:
665:
361:Dermatology: 2-Volume Set
195:cells may be seen at the
118:Spitz's juvenile melanoma
49:
40:
814:Benign melanocytic nevus
601:Lentigo maligna melanoma
114:benign juvenile melanoma
112:, and misleadingly as a
18:Benign juvenile melanoma
824:Connective tissue nevus
197:dermoepidermal junction
108:It is also known as an
252:age of 22 years and a
204:differential diagnoses
180:
173:differential diagnoses
144:
618:Desmoplastic melanoma
338:. Saunders Elsevier.
170:
135:
714:of Jadassohn–Tièche
613:Amelanotic melanoma
782:Balloon cell nevus
559:nevi and melanomas
498:External resources
212:malignant melanoma
181:
145:
836:
835:
832:
831:
658:melanocytic nevus
633:Polypoid melanoma
521:
520:
370:978-1-4160-2999-1
256:age of 19 years.
122:juvenile melanoma
97:, it affects the
95:melanocytic nevus
80:
79:
30:Medical condition
27:Benign skin tumor
16:(Redirected from
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787:Dysplastic nevus
729:Deep penetrating
663:
585:Nodular melanoma
575:Mucosal melanoma
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414:1948;24:591-609.
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638:Nevoid melanoma
597:Lentigo maligna
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512:article/1059623
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128:Pathophysiology
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809:Becker's nevus
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696:Pseudomelanoma
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430:Classification
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422:External links
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412:Am. J. Pathol.
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185:histopathology
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854:Rare diseases
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345:0-7216-2921-0
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157:chromosome 11
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141:H&E stain
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120:). The name
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819:Nevus spilus
763:Medium-sized
678:
674:Nevus of Ota
670:Nevus of Ito
589:
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442:
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321:Press. 2006.
318:
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266:Sophie Spitz
263:
247:
236:sub-tropical
229:
226:Epidemiology
221:
199:. The main
191:morphology.
182:
146:
121:
117:
113:
109:
107:
93:. A type of
83:
81:
804:Acral nevus
768:Small-sized
724:Epithelioid
679:Spitz nevus
555:Skin cancer
189:epithelioid
153:chromosomes
91:skin lesion
84:Spitz nevus
65:Dermatology
50:Spitz nevus
36:Spitz nevus
843:Categories
734:Amelanotic
709:Blue nevus
691:Halo nevus
483:DiseasesDB
294:References
239:Queensland
201:histologic
137:Micrograph
739:Malignant
507:eMedicine
467:: M8770/0
232:incidence
218:Treatment
193:Apoptotic
177:incidence
163:Diagnosis
99:epidermis
72:Prognosis
56:Specialty
719:Cellular
567:Melanoma
459:D22.L32)
317:. Lyon:
272:See also
243:melanoma
171:Various
61:Oncology
591:lentigo
477:D018332
159:(11p).
149:sunburn
367:
342:
260:Eponym
254:median
116:, and
103:dermis
88:benign
76:benign
758:Giant
653:Nevus
488:29807
464:ICD-O
86:is a
472:MeSH
457:ILDS
365:ISBN
340:ISBN
319:IARC
250:mean
210:and
206:are
101:and
557:of
453:D22
444:ICD
183:On
845::
510::
486::
475::
451::
448:10
379:^
326:^
302:^
214:.
105:.
82:A
63:,
789:/
770:)
756:(
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655:/
599:/
547:e
540:t
533:v
455:(
446:-
436:D
373:.
348:.
143:.
20:)
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