Knowledge (XXG)

Beta-synuclein

Source πŸ“

242: 219: 116: 141: 493: 248: 147: 2451: 1891:"Beta-synuclein displays an antiapoptotic p53-dependent phenotype and protects neurons from 6-hydroxydopamine-induced caspase 3 activation: cross-talk with alpha-synuclein and implication for Parkinson's disease" 255: 154: 2249: 1072:; however, no direct relation to Parkinson's disease has been established. Two transcript variants encoding the same protein have been found for this gene. 1252:
Spillantini MG, Divane A, Goedert M (Nov 1995). "Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35".
716: 697: 77: 1731:"Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins" 1819:"Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other synucleinopathies" 1612:
Rockenstein E, Hansen LA, Mallory M, et al. (2001). "Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease".
2520: 1234: 1068:. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with 2496: 2125:"A genome scale location analysis of human Staf/ZNF143-binding sites suggests a widespread role for human Staf/ZNF143 in mammalian promoters" 1216: 2515: 1852:
Fung KM, Rorke LB, Giasson B, et al. (2003). "Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas".
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D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with
241: 972: 2242: 2209: 1536:"Binding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NAC" 979: 218: 1331: 1203: 1182: 1199: 140: 115: 2235: 2215: 1398:"Beta-synuclein regulates Akt activity in neuronal cells. A possible mechanism for neuroprotection in Parkinson's disease" 1178: 57: 254: 153: 2489: 2351: 1130: 1119: 247: 146: 2381: 761: 65: 1969:"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" 2371: 742: 1649:
Tanji K, Mori F, Nakajo S, et al. (2001). "Expression of beta-synuclein in normal human astrocytes".
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Lavedan C, Leroy E, Torres R, Dehejia A, Dutra A, Buchholtz S, Nussbaum RL, Polymeropoulos MH (Jan 1999).
1138: 1134: 1115: 1069: 1065: 2090:"Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression" 2482: 2262: 1777: 1688:"beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor" 1439:"beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factor" 129: 44: 2356: 2221: 955: 930: 916: 912: 908: 904: 900: 880: 855: 851: 841: 837: 833: 825: 1877: 1717: 1674: 1637: 1522: 1468: 1053: 89: 1766:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" 951: 926: 876: 829: 2189: 2146: 2111: 2076: 2033: 1998: 1955: 1912: 1869: 1840: 1805: 1752: 1709: 1666: 1629: 1600: 1565: 1514: 1460: 1419: 1378: 1310: 1269: 37: 2466: 2179: 2171: 2136: 2101: 2066: 2058: 2023: 1988: 1980: 1945: 1937: 1902: 1861: 1830: 1795: 1785: 1742: 1699: 1658: 1621: 1590: 1555: 1547: 1504: 1450: 1409: 1396:
Hashimoto, M; Bar-On, P; Ho, G; Takenouchi, T; Rockenstein, E; Crews, L; Masliah, E (2004).
1368: 1358: 1300: 1261: 492: 334: 265: 209: 164: 2288: 2278: 2012:"beta-Synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein" 1126: 1057: 309: 85: 1145:
effects of alpha-synuclein and provide a novel treatment of neurodegenerative disorders.
1781: 2336: 2319: 2184: 2159: 2071: 2046: 1950: 1941: 1925: 1560: 1535: 1993: 1968: 1800: 1765: 1704: 1687: 1625: 1455: 1438: 1373: 1346: 631: 626: 621: 616: 611: 606: 601: 585: 580: 575: 570: 565: 549: 544: 539: 534: 2509: 2420: 2324: 2160:"Residual structure, backbone dynamics, and interactions within the synuclein family" 1662: 1509: 1492: 1142: 1083: 1061: 521: 1881: 1721: 1678: 1641: 1526: 1472: 1363: 69: 2462: 2386: 2376: 1579:"Synucleins are a novel class of substrates for G protein-coupled receptor kinases" 327: 106: 93: 2391: 2366: 2227: 1239:
National Center for Biotechnology Information, U.S. National Library of Medicine
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National Center for Biotechnology Information, U.S. National Library of Medicine
1095: 1087: 410: 2408: 2403: 2175: 1865: 1107: 1060:. These proteins are abundantly expressed in the brain and putatively inhibit 226: 123: 73: 1289:"Genomic organization and expression of the human beta-synuclein gene (SNCB)" 2270: 1154: 1111: 1091: 1076: 661: 470: 348: 293: 280: 192: 179: 81: 2193: 2150: 2141: 2124: 2115: 2080: 2037: 2028: 2011: 2002: 1959: 1916: 1907: 1890: 1873: 1844: 1835: 1818: 1809: 1790: 1756: 1747: 1730: 1713: 1670: 1633: 1604: 1595: 1578: 1464: 1423: 1414: 1397: 1382: 1305: 1265: 1569: 1518: 1314: 1273: 1019: 1014: 2398: 2309: 2106: 2089: 2062: 1103: 1099: 1003: 806: 787: 2425: 2258: 1984: 1437:
Hashimoto, M; Rockenstein, E; Mante, M; Mallory, M; Masliah, E (2001).
1079: 1049: 1035: 773: 728: 2047:"Secondary structure and dynamics of micelle bound Ξ²- and Ξ³-synuclein" 1551: 2346: 2314: 987: 683: 2450: 1288: 2430: 2341: 2304: 646: 642: 2458: 2413: 2361: 2331: 1042: 61: 2231: 501: 1090:
terminals. Beta-synuclein is predominantly expressed in the
1493:"Identification of two distinct synucleins from human brain" 1926:"Ξ²-Synuclein gene alterations in dementia with Lewy bodies" 1764:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
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Hashimoto M, Rockenstein E, Mante M, et al. (2001).
317: 2470: 1967:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
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Pronin AN, Morris AJ, Surguchov A, Benovic JL (2000).
1817:
Ihara M, Tomimoto H, Kitayama H, et al. (2003).
1114:, but it is associated with hippocampal pathology in 482: 2088:
Fan Y, Limprasert P, Murray IV, et al. (2006).
2297: 2269: 1924:Ohtake H, Limprasert P, Fan Y, et al. (2005). 944: 899: 869: 824: 421:
dentate gyrus of hippocampal formation granule cell
1729:Uversky VN, Li J, Souillac P, et al. (2002). 1534:Jensen PH, Hojrup P, Hager H, et al. (1997). 1195: 1193: 1191: 1174: 1172: 1170: 1125:Beta-synuclein is suggested to be an inhibitor of 2123:Myslinski E, GΓ©rard MA, Krol A, Carbon P (2007). 264: 163: 2010:Snyder H, Mensah K, Hsu C, et al. (2005). 602:negative regulation of neuron apoptotic process 16:Protein-coding gene in the species Homo sapiens 1200:GRCm38: Ensembl release 89: ENSMUSG00000034891 2490: 2243: 8: 1491:Jakes R, Spillantini MG, Goedert M (1994). 1179:GRCh38: Ensembl release 89: ENSG00000074317 2497: 2483: 2250: 2236: 2228: 1889:da Costa CA, Masliah E, Checler F (2003). 896: 821: 657: 517: 305: 204: 101: 2183: 2140: 2105: 2070: 2027: 1992: 1949: 1906: 1834: 1799: 1789: 1746: 1703: 1594: 1559: 1508: 1454: 1413: 1372: 1362: 1304: 622:negative regulation of catalytic activity 1326: 1324: 1166: 1137:. Thus, beta-synuclein may protect the 18: 269: 230: 225: 168: 127: 122: 7: 2447: 2445: 1402:The Journal of Biological Chemistry 1332:"Entrez Gene: SNCB synuclein, beta" 2469:. You can help Knowledge (XXG) by 1942:10.1212/01.wnl.0000139870.14385.3c 941: 866: 797: 778: 752: 733: 707: 688: 487: 453:central gray substance of midbrain 405: 343: 322: 14: 1038:that in humans is encoded by the 2449: 1663:10.1097/00001756-200109170-00018 535:phospholipase inhibitor activity 491: 253: 246: 240: 217: 152: 145: 139: 114: 1364:10.1186/gb-2001-3-1-reviews3002 1052:encoded by this gene is highly 617:chemical synaptic transmission 502:More reference expression data 471:More reference expression data 375:dorsolateral prefrontal cortex 359:right hemisphere of cerebellum 1: 2521:Human chromosome 5 gene stubs 1705:10.1016/S0896-6273(01)00462-7 1626:10.1016/S0006-8993(01)02772-X 1456:10.1016/S0896-6273(01)00462-7 1129:aggregation, which occurs in 238: 137: 48:, entrez:6620, synuclein beta 1770:Proc. Natl. Acad. Sci. U.S.A 1510:10.1016/0014-5793(94)00395-5 632:synaptic vesicle endocytosis 545:transition metal ion binding 2516:Genes on human chromosome 5 2158:Sung YH, Eliezer D (2007). 2045:Sung YH, Eliezer D (2006). 379:paraflocculus of cerebellum 2537: 2444: 2220:gene details page in the 1131:neurodegenerative diseases 612:dopamine metabolic process 2352:Brain natriuretic peptide 2176:10.1016/j.jmb.2007.07.008 1866:10.1007/s00401-003-0718-x 1235:"Mouse PubMed Reference:" 1217:"Human PubMed Reference:" 1018: 1013: 1009: 1002: 986: 973:Chr 5: 176.62 – 176.63 Mb 967: 948: 923: 892: 873: 848: 817: 804: 800: 785: 781: 772: 759: 755: 740: 736: 727: 714: 710: 695: 691: 682: 667: 660: 656: 640: 520: 516: 499: 490: 481: 468: 417: 408: 371:anterior cingulate cortex 355: 346: 316: 308: 304: 287: 274: 237: 216: 207: 203: 186: 173: 136: 113: 104: 100: 55: 52: 42: 35: 30: 26: 21: 2382:Olfactory marker protein 980:Chr 13: 54.91 – 54.91 Mb 2372:Neuronal calcium sensor 2142:10.1074/jbc.M608507200 2029:10.1074/jbc.M412887200 1908:10.1074/jbc.M306083200 1836:10.1074/jbc.M301352200 1791:10.1073/pnas.242603899 1748:10.1074/jbc.M109541200 1596:10.1074/jbc.M003542200 1415:10.1074/jbc.M313784200 1306:10.1006/geno.1998.5556 1266:10.1006/geno.1995.1063 1139:central nervous system 1110:. It is not found in 1086:and is seen mainly in 433:superior frontal gyrus 425:neural layer of retina 271:13 B1|13 29.28 cM 627:response to metal ion 429:primary visual cortex 232:Chromosome 13 (mouse) 2263:nerve tissue protein 2214:genome location and 2063:10.1110/ps.051803606 1075:Beta-synuclein is a 607:synapse organization 130:Chromosome 5 (human) 2357:Nerve growth factor 2222:UCSC Genome Browser 1782:2002PNAS...9916899M 1345:George, JM (2002). 1135:Parkinson's disease 1082:found primarily in 1070:Parkinson's disease 1066:Alzheimer's disease 550:cuprous ion binding 540:calcium ion binding 457:superior colliculus 2457:This article on a 2107:10.1093/hmg/ddl242 1985:10.1101/gr.2596504 1357:(1): REVIEWS3002. 762:ENSMUSG00000034891 595:Biological process 559:Cellular component 528:Molecular function 363:right frontal lobe 2478: 2477: 2439: 2438: 1829:(26): 24095–102. 1776:(26): 16899–903. 1552:10.1042/bj3230539 1029: 1028: 1025: 1024: 998: 997: 963: 962: 938: 937: 888: 887: 863: 862: 813: 812: 794: 793: 768: 767: 749: 748: 723: 722: 704: 703: 652: 651: 512: 511: 508: 507: 477: 476: 464: 463: 449:cerebellar cortex 441:entorhinal cortex 437:perirhinal cortex 402: 401: 300: 299: 199: 198: 2528: 2499: 2492: 2485: 2453: 2446: 2252: 2245: 2238: 2229: 2197: 2187: 2154: 2144: 2135:(52): 39953–62. 2119: 2109: 2084: 2074: 2041: 2031: 2006: 1996: 1963: 1953: 1920: 1910: 1885: 1854:Acta Neuropathol 1848: 1838: 1813: 1803: 1793: 1760: 1750: 1725: 1707: 1682: 1645: 1608: 1598: 1589:(34): 26515–22. 1573: 1563: 1546:(Pt 2): 539–46. 1530: 1512: 1477: 1476: 1458: 1434: 1428: 1427: 1417: 1393: 1387: 1386: 1376: 1366: 1347:"The synucleins" 1342: 1336: 1335: 1328: 1319: 1318: 1308: 1284: 1278: 1277: 1249: 1243: 1242: 1231: 1225: 1224: 1213: 1207: 1197: 1186: 1176: 1011: 1010: 982: 975: 958: 942: 933: 897: 893:RefSeq (protein) 883: 867: 858: 822: 798: 779: 753: 734: 708: 689: 658: 518: 504: 495: 488: 473: 413: 411:Top expressed in 406: 367:Brodmann area 10 351: 349:Top expressed in 344: 323: 306: 296: 283: 272: 257: 250: 244: 233: 221: 205: 195: 182: 171: 156: 149: 143: 132: 118: 102: 96: 94:SNCB - orthologs 47: 40: 19: 2536: 2535: 2531: 2530: 2529: 2527: 2526: 2525: 2506: 2505: 2504: 2503: 2442: 2440: 2435: 2293: 2289:Gamma-synuclein 2279:Alpha-synuclein 2265: 2256: 2205: 2200: 2157: 2122: 2100:(20): 3002–11. 2094:Hum. Mol. Genet 2087: 2044: 2009: 1979:(10B): 2121–7. 1966: 1923: 1901:(39): 37330–5. 1888: 1851: 1816: 1763: 1741:(14): 11970–8. 1728: 1685: 1648: 1611: 1576: 1533: 1490: 1486: 1484:Further reading 1481: 1480: 1436: 1435: 1431: 1408:(22): 23622–9. 1395: 1394: 1390: 1344: 1343: 1339: 1330: 1329: 1322: 1286: 1285: 1281: 1251: 1250: 1246: 1233: 1232: 1228: 1215: 1214: 1210: 1198: 1189: 1177: 1168: 1163: 1151: 1127:alpha-synuclein 1058:alpha-synuclein 1020:View/Edit Mouse 1015:View/Edit Human 978: 971: 968:Location (UCSC) 954: 950: 929: 925: 919: 915: 911: 907: 903: 879: 875: 854: 850: 844: 840: 836: 832: 828: 743:ENSG00000074317 636: 590: 554: 500: 469: 460: 455: 451: 447: 443: 439: 435: 431: 427: 423: 409: 398: 393: 389: 385: 383:Brodmann area 9 381: 377: 373: 369: 365: 361: 347: 291: 278: 270: 260: 259: 258: 251: 231: 208:Gene location ( 190: 177: 169: 159: 158: 157: 150: 128: 105:Gene location ( 56: 43: 36: 17: 12: 11: 5: 2534: 2532: 2524: 2523: 2518: 2508: 2507: 2502: 2501: 2494: 2487: 2479: 2476: 2475: 2454: 2437: 2436: 2434: 2433: 2428: 2423: 2418: 2417: 2416: 2411: 2406: 2396: 2395: 2394: 2384: 2379: 2374: 2369: 2364: 2359: 2354: 2349: 2344: 2339: 2337:Gap-43 protein 2334: 2329: 2328: 2327: 2322: 2320:Chromogranin A 2312: 2307: 2301: 2299: 2295: 2294: 2292: 2291: 2286: 2284:Beta-synuclein 2281: 2275: 2273: 2267: 2266: 2257: 2255: 2254: 2247: 2240: 2232: 2226: 2225: 2204: 2203:External links 2201: 2199: 2198: 2170:(3): 689–707. 2155: 2120: 2085: 2057:(5): 1162–74. 2042: 2007: 1964: 1921: 1886: 1849: 1814: 1761: 1726: 1683: 1657:(13): 2845–8. 1646: 1620:(1–2): 48–56. 1609: 1574: 1531: 1487: 1485: 1482: 1479: 1478: 1429: 1388: 1351:Genome Biology 1337: 1320: 1279: 1244: 1226: 1208: 1187: 1165: 1164: 1162: 1159: 1158: 1157: 1150: 1147: 1032:Beta-synuclein 1027: 1026: 1023: 1022: 1017: 1007: 1006: 1000: 999: 996: 995: 993: 991: 984: 983: 976: 969: 965: 964: 961: 960: 946: 945: 939: 936: 935: 921: 920: 894: 890: 889: 886: 885: 871: 870: 864: 861: 860: 846: 845: 819: 815: 814: 811: 810: 802: 801: 795: 792: 791: 783: 782: 776: 770: 769: 766: 765: 757: 756: 750: 747: 746: 738: 737: 731: 725: 724: 721: 720: 712: 711: 705: 702: 701: 693: 692: 686: 680: 679: 674: 669: 665: 664: 654: 653: 650: 649: 638: 637: 635: 634: 629: 624: 619: 614: 609: 604: 598: 596: 592: 591: 589: 588: 583: 578: 573: 568: 566:inclusion body 562: 560: 556: 555: 553: 552: 547: 542: 537: 531: 529: 525: 524: 514: 513: 510: 509: 506: 505: 497: 496: 485: 479: 478: 475: 474: 466: 465: 462: 461: 459: 458: 454: 450: 446: 442: 438: 434: 430: 426: 422: 418: 415: 414: 403: 400: 399: 397: 396: 392: 388: 384: 380: 376: 372: 368: 364: 360: 356: 353: 352: 340: 339: 331: 320: 314: 313: 310:RNA expression 302: 301: 298: 297: 289: 285: 284: 276: 273: 268: 262: 261: 252: 245: 239: 235: 234: 229: 223: 222: 214: 213: 201: 200: 197: 196: 188: 184: 183: 175: 172: 167: 161: 160: 151: 144: 138: 134: 133: 126: 120: 119: 111: 110: 98: 97: 54: 50: 49: 41: 33: 32: 28: 27: 24: 23: 15: 13: 10: 9: 6: 4: 3: 2: 2533: 2522: 2519: 2517: 2514: 2513: 2511: 2500: 2495: 2493: 2488: 2486: 2481: 2480: 2474: 2472: 2468: 2464: 2460: 2455: 2452: 2448: 2443: 2432: 2429: 2427: 2424: 2422: 2421:Synaptophysin 2419: 2415: 2412: 2410: 2407: 2405: 2402: 2401: 2400: 2397: 2393: 2390: 2389: 2388: 2385: 2383: 2380: 2378: 2375: 2373: 2370: 2368: 2365: 2363: 2360: 2358: 2355: 2353: 2350: 2348: 2345: 2343: 2340: 2338: 2335: 2333: 2330: 2326: 2323: 2321: 2318: 2317: 2316: 2313: 2311: 2308: 2306: 2303: 2302: 2300: 2296: 2290: 2287: 2285: 2282: 2280: 2277: 2276: 2274: 2272: 2268: 2264: 2260: 2253: 2248: 2246: 2241: 2239: 2234: 2233: 2230: 2223: 2219: 2218: 2213: 2212: 2207: 2206: 2202: 2195: 2191: 2186: 2181: 2177: 2173: 2169: 2165: 2161: 2156: 2152: 2148: 2143: 2138: 2134: 2130: 2129:J. Biol. Chem 2126: 2121: 2117: 2113: 2108: 2103: 2099: 2095: 2091: 2086: 2082: 2078: 2073: 2068: 2064: 2060: 2056: 2052: 2048: 2043: 2039: 2035: 2030: 2025: 2022:(9): 7562–9. 2021: 2017: 2016:J. Biol. Chem 2013: 2008: 2004: 2000: 1995: 1990: 1986: 1982: 1978: 1974: 1970: 1965: 1961: 1957: 1952: 1947: 1943: 1939: 1936:(5): 805–11. 1935: 1931: 1927: 1922: 1918: 1914: 1909: 1904: 1900: 1896: 1895:J. Biol. Chem 1892: 1887: 1883: 1879: 1875: 1871: 1867: 1863: 1860:(2): 167–75. 1859: 1855: 1850: 1846: 1842: 1837: 1832: 1828: 1824: 1823:J. Biol. Chem 1820: 1815: 1811: 1807: 1802: 1797: 1792: 1787: 1783: 1779: 1775: 1771: 1767: 1762: 1758: 1754: 1749: 1744: 1740: 1736: 1735:J. Biol. Chem 1732: 1727: 1723: 1719: 1715: 1711: 1706: 1701: 1698:(2): 213–23. 1697: 1693: 1689: 1684: 1680: 1676: 1672: 1668: 1664: 1660: 1656: 1652: 1647: 1643: 1639: 1635: 1631: 1627: 1623: 1619: 1615: 1610: 1606: 1602: 1597: 1592: 1588: 1584: 1583:J. Biol. Chem 1580: 1575: 1571: 1567: 1562: 1557: 1553: 1549: 1545: 1541: 1537: 1532: 1528: 1524: 1520: 1516: 1511: 1506: 1502: 1498: 1494: 1489: 1488: 1483: 1474: 1470: 1466: 1462: 1457: 1452: 1449:(2): 213–23. 1448: 1444: 1440: 1433: 1430: 1425: 1421: 1416: 1411: 1407: 1403: 1399: 1392: 1389: 1384: 1380: 1375: 1370: 1365: 1360: 1356: 1352: 1348: 1341: 1338: 1333: 1327: 1325: 1321: 1316: 1312: 1307: 1302: 1298: 1294: 1290: 1283: 1280: 1275: 1271: 1267: 1263: 1260:(2): 379–81. 1259: 1255: 1248: 1245: 1240: 1236: 1230: 1227: 1222: 1218: 1212: 1209: 1205: 1201: 1196: 1194: 1192: 1188: 1184: 1180: 1175: 1173: 1171: 1167: 1160: 1156: 1153: 1152: 1148: 1146: 1144: 1140: 1136: 1132: 1128: 1123: 1121: 1117: 1113: 1109: 1105: 1101: 1097: 1093: 1089: 1085: 1081: 1078: 1073: 1071: 1067: 1063: 1062:phospholipase 1059: 1055: 1051: 1046: 1044: 1041: 1037: 1033: 1021: 1016: 1012: 1008: 1005: 1001: 994: 992: 989: 985: 981: 977: 974: 970: 966: 959: 957: 953: 947: 943: 940: 934: 932: 928: 922: 918: 914: 910: 906: 902: 898: 895: 891: 884: 882: 878: 872: 868: 865: 859: 857: 853: 847: 843: 839: 835: 831: 827: 823: 820: 818:RefSeq (mRNA) 816: 809: 808: 803: 799: 796: 790: 789: 784: 780: 777: 775: 771: 764: 763: 758: 754: 751: 745: 744: 739: 735: 732: 730: 726: 719: 718: 713: 709: 706: 700: 699: 694: 690: 687: 685: 681: 678: 675: 673: 670: 666: 663: 659: 655: 648: 644: 639: 633: 630: 628: 625: 623: 620: 618: 615: 613: 610: 608: 605: 603: 600: 599: 597: 594: 593: 587: 584: 582: 579: 577: 574: 572: 569: 567: 564: 563: 561: 558: 557: 551: 548: 546: 543: 541: 538: 536: 533: 532: 530: 527: 526: 523: 522:Gene ontology 519: 515: 503: 498: 494: 489: 486: 484: 480: 472: 467: 456: 452: 448: 444: 440: 436: 432: 428: 424: 420: 419: 416: 412: 407: 404: 394: 390: 386: 382: 378: 374: 370: 366: 362: 358: 357: 354: 350: 345: 342: 341: 338: 336: 332: 330: 329: 325: 324: 321: 319: 315: 311: 307: 303: 295: 290: 286: 282: 277: 267: 263: 256: 249: 243: 236: 228: 224: 220: 215: 211: 206: 202: 194: 189: 185: 181: 176: 166: 162: 155: 148: 142: 135: 131: 125: 121: 117: 112: 108: 103: 99: 95: 91: 87: 83: 79: 75: 71: 67: 63: 59: 51: 46: 39: 34: 29: 25: 20: 2471:expanding it 2463:chromosome 5 2456: 2441: 2387:S100 protein 2377:Neuropeptide 2283: 2216: 2210: 2167: 2164:J. Mol. Biol 2163: 2132: 2128: 2097: 2093: 2054: 2050: 2019: 2015: 1976: 1972: 1933: 1929: 1898: 1894: 1857: 1853: 1826: 1822: 1773: 1769: 1738: 1734: 1695: 1691: 1654: 1650: 1617: 1613: 1586: 1582: 1543: 1539: 1503:(1): 27–32. 1500: 1496: 1446: 1442: 1432: 1405: 1401: 1391: 1354: 1350: 1340: 1299:(1): 173–5. 1296: 1292: 1282: 1257: 1253: 1247: 1238: 1229: 1220: 1211: 1124: 1084:brain tissue 1074: 1047: 1039: 1031: 1030: 956:NP_001349336 949: 931:NP_001350069 924: 917:NP_001304966 913:NP_001304965 909:NP_001304964 905:NP_001304963 901:NP_001001502 881:NM_001362407 874: 856:NM_001363140 852:NM_001318037 849: 842:NM_001318036 838:NM_001318035 834:NM_001318034 826:NM_001001502 805: 786: 760: 741: 715: 696: 676: 671: 395:hypothalamus 387:frontal pole 333: 326: 191:176,630,556 178:176,620,082 53:External IDs 2392:Calgranulin 2367:Neurogranin 2051:Protein Sci 1651:NeuroReport 1112:Lewy bodies 1096:hippocampus 1088:presynaptic 292:54,914,408 279:54,906,673 31:Identifiers 2510:Categories 1973:Genome Res 1540:Biochem. J 1206:, May 2017 1185:, May 2017 1161:References 1143:neurotoxic 1108:cerebellum 1054:homologous 586:presynapse 337:(ortholog) 74:HomoloGene 2461:on human 2271:Synuclein 1930:Neurology 1614:Brain Res 1497:FEBS Lett 1155:Synuclein 1141:from the 1092:neocortex 1077:synuclein 952:NP_291088 927:NP_003076 877:NM_033610 830:NM_003085 662:Orthologs 576:cytoplasm 445:CA3 field 82:GeneCards 2399:Synapsin 2310:Chimerin 2194:17681534 2151:17092945 2116:16959793 2081:16597821 2038:15591046 2003:15489334 1960:15365127 1917:12867415 1882:39712533 1874:12783249 1845:12695511 1810:12477932 1757:11812782 1722:14766899 1714:11683992 1679:84671534 1671:11588588 1642:35448948 1634:11578596 1605:10852916 1527:36840279 1473:14766899 1465:11683992 1424:15026413 1383:11806835 1293:Genomics 1254:Genomics 1202:– 1181:– 1149:See also 1133:such as 1104:thalamus 1100:striatum 1004:Wikidata 641:Sources: 391:amygdala 2426:Tubulin 2259:Protein 2185:2094134 2072:2242515 1951:1808539 1778:Bibcode 1570:9163350 1561:1218353 1519:8194594 1315:9806846 1274:7558013 1204:Ensembl 1183:Ensembl 1080:protein 1050:protein 1036:protein 774:UniProt 729:Ensembl 668:Species 647:QuickGO 581:cytosol 571:synapse 312:pattern 70:1889011 38:Aliases 2347:Myelin 2315:Granin 2208:Human 2192:  2182:  2149:  2114:  2079:  2069:  2036:  2001:  1994:528928 1991:  1958:  1948:  1915:  1880:  1872:  1843:  1808:  1801:139241 1798:  1755:  1720:  1712:  1692:Neuron 1677:  1669:  1640:  1632:  1603:  1568:  1558:  1525:  1517:  1471:  1463:  1443:Neuron 1422:  1381:  1374:150459 1371:  1313:  1272:  1106:, and 990:search 988:PubMed 807:Q91ZZ3 788:Q16143 717:104069 684:Entrez 483:BioGPS 170:5q35.2 62:602569 2465:is a 2431:GPM6A 2342:GLUT3 2305:Agrin 2298:Other 1878:S2CID 1718:S2CID 1675:S2CID 1638:S2CID 1523:S2CID 1469:S2CID 1034:is a 677:Mouse 672:Human 643:Amigo 335:Mouse 328:Human 275:Start 210:Mouse 174:Start 107:Human 2467:stub 2459:gene 2362:SCG5 2332:FMR1 2217:SNCB 2211:SNCB 2190:PMID 2147:PMID 2112:PMID 2077:PMID 2034:PMID 1999:PMID 1956:PMID 1913:PMID 1870:PMID 1841:PMID 1806:PMID 1753:PMID 1710:PMID 1667:PMID 1630:PMID 1601:PMID 1566:PMID 1515:PMID 1461:PMID 1420:PMID 1379:PMID 1311:PMID 1270:PMID 1118:and 1048:The 1043:gene 1040:SNCB 698:6620 318:Bgee 266:Band 227:Chr. 165:Band 124:Chr. 86:SNCB 78:2320 58:OMIM 45:SNCB 22:SNCB 2180:PMC 2172:doi 2168:372 2137:doi 2133:281 2102:doi 2067:PMC 2059:doi 2024:doi 2020:280 1989:PMC 1981:doi 1946:PMC 1938:doi 1903:doi 1899:278 1862:doi 1858:106 1831:doi 1827:278 1796:PMC 1786:doi 1743:doi 1739:277 1700:doi 1659:doi 1622:doi 1618:914 1591:doi 1587:275 1556:PMC 1548:doi 1544:323 1505:doi 1501:345 1451:doi 1410:doi 1406:279 1369:PMC 1359:doi 1301:doi 1262:doi 1120:DLB 1056:to 288:End 187:End 90:OMA 66:MGI 2512:: 2261:: 2188:. 2178:. 2166:. 2162:. 2145:. 2131:. 2127:. 2110:. 2098:15 2096:. 2092:. 2075:. 2065:. 2055:15 2053:. 2049:. 2032:. 2018:. 2014:. 1997:. 1987:. 1977:14 1975:. 1971:. 1954:. 1944:. 1934:63 1932:. 1928:. 1911:. 1897:. 1893:. 1876:. 1868:. 1856:. 1839:. 1825:. 1821:. 1804:. 1794:. 1784:. 1774:99 1772:. 1768:. 1751:. 1737:. 1733:. 1716:. 1708:. 1696:32 1694:. 1690:. 1673:. 1665:. 1655:12 1653:. 1636:. 1628:. 1616:. 1599:. 1585:. 1581:. 1564:. 1554:. 1542:. 1538:. 1521:. 1513:. 1499:. 1495:. 1467:. 1459:. 1447:32 1445:. 1441:. 1418:. 1404:. 1400:. 1377:. 1367:. 1353:. 1349:. 1323:^ 1309:. 1297:54 1295:. 1291:. 1268:. 1258:27 1256:. 1237:. 1219:. 1190:^ 1169:^ 1122:. 1116:PD 1102:, 1098:, 1094:, 1045:. 645:/ 294:bp 281:bp 193:bp 180:bp 88:; 84:: 80:; 76:: 72:; 68:: 64:; 60:: 2498:e 2491:t 2484:v 2473:. 2414:3 2409:2 2404:1 2325:B 2251:e 2244:t 2237:v 2224:. 2196:. 2174:: 2153:. 2139:: 2118:. 2104:: 2083:. 2061:: 2040:. 2026:: 2005:. 1983:: 1962:. 1940:: 1919:. 1905:: 1884:. 1864:: 1847:. 1833:: 1812:. 1788:: 1780:: 1759:. 1745:: 1724:. 1702:: 1681:. 1661:: 1644:. 1624:: 1607:. 1593:: 1572:. 1550:: 1529:. 1507:: 1475:. 1453:: 1426:. 1412:: 1385:. 1361:: 1355:3 1334:. 1317:. 1303:: 1276:. 1264:: 1241:. 1223:. 212:) 109:) 92::

Index

Aliases
SNCB
OMIM
602569
MGI
1889011
HomoloGene
2320
GeneCards
SNCB
OMA
SNCB - orthologs
Human
Chromosome 5 (human)
Chr.
Chromosome 5 (human)
Chromosome 5 (human)
Genomic location for SNCB
Genomic location for SNCB
Band
bp
bp
Mouse
Chromosome 13 (mouse)
Chr.
Chromosome 13 (mouse)
Genomic location for SNCB
Genomic location for SNCB
Band
bp

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