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Swietenia macrophylla

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cyclooxygenase-2 (COX-2), tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6). SMEAF inhibited nuclear translocation of nuclear factor-kappa B (NF-κB) via the attenuation of IκBα phosphorylation. Moreover, SMEAF markedly suppressed phosphorylation of Akt, p38 Mitogen-activated protein kinase (MAPK) and Extracellular signal-regulated kinase 1/2 (ERK1/2) in LPS-induced BV-2 cells. Treatment with specific inhibitors for Akt, NF-κB, p38 and ERK1/2 resulted in the attenuation of iNOS and COX-2 protein expression. These findings indicated that SMEAF possesses anti-inflammatory activities in BV-2 cells by modulating LPS-induced pro-inflammatory mediator production via the inhibition of Akt-dependent NF-κB, p38 MAPK and ERK1/2 activation. These results further advocate the potential use of S. macrophylla as nutraceutical for the intervention of neurodegenerative and neuroinflammatory disorders.
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It was scientifically studied for its various biological activities. A detailed mechanism of action of apoptotic inducing effect on HCT116 human cancer cell line was elucidated. Through solvent extraction and fractionation done on seeds of Swietenia macrophylla, the ethyl acetate fraction (SMEAF)
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However, there are reports of liver injury or hepatotoxicity after consumption of Mahogany Seeds both in raw form and raw seeds grind and pack in capsule form. The severity of liver damage varies. There are also the report of single case kidney injury and polyarthralgia. In most cases, the liver
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The ethyl acetate fraction from the seeds of Swietenia macrophylla (SMEAF) was studied for anti-inflammatory properties using lipopolysaccharide (LPS)-induced BV-2 microglia. SMEAF significantly attenuated the LPS-induced production of nitric oxide (NO), inducible nitric oxide synthase (iNOS),
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was further examined for its neuroprotective activity and acute toxicity effects. Various purified compounds derived from Swietenia macrophylla were further examined and was revealed to possesses potent PPARγ binding activity which might capable of stimulating glucose uptake in muscle cells.
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Supriady, Hadi; Kamarudin, Muhamad Noor Alfarizal; Chan, Chim Kei; Goh, Bey Hing; Kadir, Habsah Abdul (2015). "SMEAF attenuates the production of pro-inflammatory mediators through the inactivation of Akt-dependent NF-κB, p38 and ERK1/2 pathways in LPS-stimulated BV-2 microglial cells".
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Unlike mahogany sourced from its native locations, plantation mahogany grown in Asia is not restricted in trade. The mahogany timber grown in these Asian plantations is the major source of international trade in genuine mahogany today. The Asian countries which grow the majority of
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These cases that happened are the first reports of Swietenia Macrophylla seeds’ association with liver injury. This may also due to over dosage and consumption of contaminated raw seeds which are never been thoroughly investigated. Based on acute oral toxicity studies of
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The fruits are called "sky fruits" because of its upwards growth towards the sky. The fruits of mahogany can be measure to 40 cm (15.7 in) in length, in a light grey to brown capsule. Each fruit capsule could contain 71 winged seeds.
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Goh, Bey Hing; Chan, Chim Kei; Kamarudin, Muhamad Noor Alfarizal; Abdul Kadir, Habsah (2014). "Swietenia macrophylla King induces mitochondrial-mediated apoptosis through p53 upregulation in HCT116 colorectal carcinoma cells".
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seeds, the consumption of Swietenia Macrophylla by humans is safe if the dose is less than 325 mg/kg body weight. The usual dose of Swietenia Macrophylla prescribed in Malaysian folk-lore medicine is one seed per day.
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Pennington, R. Toby; Lavin, Matt; Oliveira-Filho, Ary (2009). "Woody Plant Diversity, Evolution, and Ecology in the Tropics: Perspectives from Seasonally Dry Tropical Forests".
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Mahogany is characterised by its large leaves, up to 45 cm (17 in) long. The leaflets are even in number and are connected by a central midrib.
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Balijepalli, Madhu Katyayani; Suppaiah, Velan; Chin, An-me; Buru, Ayuba Sunday; Sagineedu, Sreenivasa Rao; Pichika, Mallikarjuna Rao (2015).
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Sayyad, Mustak; Tiang, Ning; Kumari, Yatinesh; Goh, Bey Hing; Jaiswal, Yogini; Rosli, Rozita; Williams, Leonard; Shaikh, Mohd Farooq (2017).
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There are also claims of its ability to improve blood circulation and skin condition, as well as anti-erectile dysfunction.
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Historic distribution of mahogany from Mexico to southeastern Amazonia according to Lamb (1966). From Martinez et al. 2008.
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function was recovered after stopping the consumption. The exact mechanism of these adverse events is currently unknown.
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Mahogany wood is strong and is usually a source for furniture, musical instruments, ships, doors, coffins, decors.
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Revised historic distribution of mahogany in South America based on expert surveys. From Martinez et al. 2008.
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Ming Fock, Kwong; Kiong Teo, Eng; Vasudevan, Archana; Wah Soe, Wint; Yee Leong, Wai; Joanna (2018-09-01).
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Lau, Wai; Goh, Bey; Kadir, Habsah; Shu-Chien, Alexander; Tengku Muhammad, Tengku (2015).
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Historic distribution of mahogany in Mexico and Central America. From Calvo et al. 2000.
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Moghadamtousi, Soheil; Goh, Bey; Chan, Chim; Shabab, Tara; Kadir, Habsah (2013).
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Moghadamtousi, Soheil; Goh, Bey; Chan, Chim; Shabab, Tara; Kadir, Habsah (2013).
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English - big leaf mahogany, large-leaved mahogany, Brazilian mahogany
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The seeds of mahogany can reach 7 to 12 cm (2.7 to 4.7 in) long.
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family. It is one of three species that yields genuine
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International Federation of Building and Wood Workers
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Historic range of big-leaf mahogany in South America
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Annual Review of Ecology, Evolution, and Systematics
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Current range of big-leaf mahogany in South America
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Permanent Agriculture Resources. p. 57. 1647: 536: 530:acajou à grandes feuilles, acajou du Honduras 8: 785:: CS1 maint: multiple names: authors list ( 528: 3313: 2829: 2358: 1882: 1654: 1640: 1632: 1046:"Swietenia macrophylla: Big-leaf mahogany" 242: 228: 61: 42: 31: 1515: 1497: 1288: 1278: 1237: 1152: 1142: 1101: 1091: 1050:Forest Research Institute Malaysia (FRIM) 970: 3162:Building and Wood Workers' International 1438:Health Sciences Authority Press Release 1013:Agroforestry Guides for Pacific Islands 850:United States Department of Agriculture 841:Germplasm Resources Information Network 741: 577: 291:Swietenia macrophylla var. marabaensis 1408: 1039: 1037: 1035: 1033: 923: 826: 824: 822: 778: 516:The species is also known under other 1581:"Flowers of India: Big-leaf mahogany" 1559:10.1146/annurev.ecolsys.110308.120327 883:The PLANTS Database (plants.usda.gov) 807:from the original on 27 February 2019 749:Barstow, M. & Negrão, R. (2023). 7: 3596:8f5a59f5-9459-49bc-88f5-17f750596ffa 3297: 3840:Invasive plant species in Sri Lanka 3287: 3147:American Association of Woodturners 760:IUCN Red List of Threatened Species 500:rainforest populations show higher 1010:Elevitch CR, Wilkinson KM (2000). 25: 3177:National Wood Carvers Association 1380:Rheumatology Advances in Practice 945:Cernansky, Rachel (August 2018). 3720:IUCN Red List endangered species 3648:urn:lsid:ipni.org:names:246905-2 3296: 3286: 3277: 3276: 3152:Architectural Woodwork Institute 1619: 1607: 724: 712: 700: 688: 676: 664: 652: 640: 628: 616: 604: 592: 580: 86: 1587:from the original on 2015-05-23 1462:from the original on 2019-02-26 1398:from the original on 2019-06-11 1351:from the original on 2019-02-27 1056:from the original on 2019-02-27 947:"How to plant a trillion trees" 3157:British Woodworking Federation 647:Bark pattern on mahogany tree. 570: 562: 553: 545: 1: 3167:Caricature Carvers of America 846:Agricultural Research Service 1218:Saudi Pharmaceutical Journal 1179:Journal of Ethnopharmacology 1315:Journal of Functional Foods 3856: 3830:National symbols of Belize 1280:10.3390/molecules201219847 1230:10.1016/j.jsps.2016.05.002 1144:10.3390/molecules180910465 1093:10.3390/molecules180910465 972:10.1038/d41586-018-06031-x 563:mahagani, peddakulamaghani 3800:Trees of Northern America 3272: 3182:Society of Wood Engravers 2361: 1327:10.1016/j.jff.2015.05.042 1191:10.1016/j.jep.2014.02.036 930:: CS1 maint: unfit URL ( 537: 529: 262: 255: 250: 241: 236: 227: 210: 203: 83:Scientific classification 81: 59: 50: 41: 34: 3835:Trees of the Philippines 1499:10.4103/0974-8490.147197 1394:(inactive 2024-09-12). 3770:Trees of French Guiana 3259:Frameless construction 2340:Wood-plastic composite 1486:Pharmacognosy Research 1392:10.1093/rap/rky034.005 719:Green leaves turn red. 3391:swietenia-macrophylla 3357:Swietenia macrophylla 3327:Swietenia macrophylla 1626:Swietenia macrophylla 1614:Swietenia macrophylla 877:Swietenia macrophylla 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3825:Vulnerable plants 3790:Trees of Honduras 3755:Trees of Dominica 3745:Trees of Colombia 3707: 3706: 3604:Open Tree of Life 3319:Taxon identifiers 3310: 3309: 3264:Green woodworking 3121:Wood preservation 3049: 3048: 2952:Tongue and groove 2932:Mortise and tenon 2821: 2820: 2519:Warrington hammer 2348: 2347: 2036:African Blackwood 1828:Segmented turning 1612:Media related to 957:(7720): 542–544. 635:Fruit with leaves 358:Swietenia humilis 331:big-leaf mahogany 327:Honduras mahogany 323:Honduran mahogany 310: 309: 303: 295: 287: 279: 271: 76: 18:Big-leaf Mahogany 16:(Redirected from 3847: 3760:Trees of Ecuador 3735:Trees of Bolivia 3700: 3699: 3687: 3686: 3677: 3676: 3664: 3663: 3651: 3650: 3638: 3637: 3625: 3624: 3612: 3611: 3599: 3598: 3589: 3588: 3576: 3575: 3563: 3562: 3550: 3549: 3537: 3536: 3524: 3523: 3511: 3510: 3498: 3497: 3485: 3484: 3472: 3471: 3459: 3458: 3446: 3445: 3433: 3432: 3420: 3419: 3407: 3406: 3394: 3393: 3381: 3380: 3371: 3370: 3361: 3360: 3359: 3346: 3345: 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seed. 658: 651: 649: 646: 639: 637: 634: 627: 625: 622: 615: 613: 610: 603: 601: 598: 591: 589: 587:Mahogany trees 586: 579: 576: 575: 566: 558: 549: 541: 533: 525: 513: 510: 494: 491: 465: 462: 420: 417: 412: 409: 403: 400: 395: 392: 387: 384: 382: 379: 308: 307: 305: 304: 296: 288: 280: 272: 263: 260: 259: 253: 252: 248: 247: 239: 238: 234: 233: 225: 224: 219: 208: 207: 201: 200: 193: 191: 187: 186: 179: 175: 174: 169: 165: 164: 159: 155: 154: 149: 142: 141: 136: 129: 128: 123: 116: 115: 110: 103: 102: 97: 93: 92: 79: 78: 60: 57: 56: 51: 48: 47: 39: 38: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 3852: 3841: 3838: 3836: 3833: 3831: 3828: 3826: 3823: 3821: 3818: 3816: 3815:Trees of Peru 3813: 3811: 3808: 3806: 3803: 3801: 3798: 3796: 3793: 3791: 3788: 3786: 3783: 3781: 3778: 3776: 3773: 3771: 3768: 3766: 3763: 3761: 3758: 3756: 3753: 3751: 3748: 3746: 3743: 3741: 3738: 3736: 3733: 3731: 3728: 3726: 3723: 3721: 3718: 3717: 3715: 3698: 3693: 3689: 3685: 3679: 3675: 3670: 3666: 3662: 3657: 3653: 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2265: 2263: 2260: 2258: 2255: 2253: 2250: 2248: 2245: 2243: 2240: 2238: 2237:Red Quebracho 2235: 2233: 2230: 2228: 2225: 2223: 2220: 2218: 2215: 2213: 2210: 2208: 2205: 2203: 2200: 2198: 2195: 2193: 2190: 2188: 2185: 2182: 2181: 2176: 2175: 2170: 2167: 2165: 2162: 2160: 2157: 2155: 2154: 2149: 2147: 2144: 2142: 2139: 2137: 2134: 2132: 2129: 2127: 2124: 2122: 2119: 2117: 2114: 2112: 2109: 2107: 2104: 2102: 2099: 2097: 2094: 2092: 2089: 2087: 2084: 2082: 2079: 2077: 2074: 2072: 2069: 2067: 2064: 2062: 2059: 2057: 2054: 2052: 2049: 2047: 2044: 2042: 2039: 2037: 2034: 2032: 2029: 2027: 2024: 2022: 2019: 2017: 2014: 2012: 2009: 2007: 2004: 2002: 1999: 1997: 1994: 1992: 1989: 1987: 1984: 1982: 1979: 1977: 1974: 1973: 1971: 1969: 1965: 1959: 1956: 1954: 1951: 1949: 1946: 1944: 1941: 1939: 1936: 1934: 1931: 1929: 1926: 1924: 1921: 1919: 1916: 1914: 1911: 1908: 1907: 1902: 1901: 1896: 1893: 1892: 1890: 1888: 1884: 1881: 1879: 1875: 1869: 1866: 1864: 1861: 1859: 1856: 1854: 1851: 1849: 1846: 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Retrieved 1575: 1546: 1540: 1534: 1492:(1): 38–44. 1489: 1485: 1475: 1464:. Retrieved 1455: 1446: 1437: 1425: 1411:cite journal 1400:. Retrieved 1383: 1379: 1353:. Retrieved 1344: 1335: 1318: 1314: 1307: 1270: 1266: 1256: 1221: 1217: 1207: 1182: 1178: 1171: 1134: 1130: 1120: 1083: 1079: 1069: 1058:. Retrieved 1049: 1012: 1005: 954: 950: 940: 914:. Retrieved 909: 899: 887:. Retrieved 882: 876: 865: 853:. Retrieved 839: 833: 809:. Retrieved 795: 781:cite journal 769:. Retrieved 764: 758: 752: 744: 543:Malayalam - 518:common names 515: 512:Common names 504:than in the 498:Mesoamerican 496: 485: 482: 478: 475: 471: 467: 425: 422: 414: 405: 397: 389: 356: 350: 330: 326: 322: 318: 313: 312: 311: 298: 290: 282: 274: 266: 213: 211: 195: 194: 182: 145: 132: 119: 106: 35: 29: 3622:kew-2601504 3568:NatureServe 3503:iNaturalist 3351:Wikispecies 3292:WikiProject 3238:Rift sawing 3228:Flat sawing 3116:Wood drying 2793:Scrub plane 2778:Razee plane 2728:Block plane 2582:Mitre clamp 2529:Wood scribe 2480:Combination 2222:Purpleheart 1918:Douglas fir 1868:Woodturning 1701:Occupations 1663:Woodworking 1553:: 437–457. 1386:(suppl_1). 1321:: 434–448. 811:20 December 771:12 December 450:Philippines 381:Description 367:Philippines 363:naturalized 126:Angiosperms 3714:Categories 3617:Plant List 3247:Techniques 3196:Conversion 3126:Wood stain 3054:Treatments 2842:Birdsmouth 2808:Spokeshave 2758:Jack plane 2748:Fore plane 2587:Pipe clamp 2552:Band clamp 2476:Carpenters 2297:Engineered 2247:Rubberwood 2096:Eucalyptus 1900:Calocedrus 1813:Pyrography 1778:Kohlrosing 1591:2015-07-12 1466:2019-02-26 1402:2019-06-08 1355:2019-02-26 1060:2019-02-26 889:4 December 871:USDA, NRCS 855:5 November 737:References 611:Young Bark 599:Young tree 568:Sinhala - 535:Spanish - 442:Bangladesh 162:Sapindales 68:Endangered 3725:Swietenia 3469:242414433 3342:Q12955947 3036:Parquetry 3031:Oystering 3026:Marquetry 2867:Butterfly 2534:Workbench 2466:Sandpaper 2446:Mitre box 2391:Drawknife 2381:Burnisher 2366:Abrasives 2315:Hardboard 1976:Afromosia 1858:Whittling 1808:Parquetry 1793:Marquetry 1738:Certosina 1733:Carpentry 1723:Cabinetry 1670:Overviews 1567:1543-592X 1508:0976-4836 1267:Molecules 1131:Molecules 1080:Molecules 981:0028-0836 910:Swietking 560:Telugu - 557:(தேன்கனி) 527:French - 502:structure 454:Singapore 434:Indonesia 371:Singapore 347:Swietenia 339:Meliaceae 190:Species: 183:Swietenia 172:Meliaceae 96:Kingdom: 3674:20400346 3669:Tropicos 3656:Species+ 3573:2.151735 3534:11432013 3521:246905-2 3336:Wikidata 3282:Category 3061:Adhesive 3041:Purfling 3021:Intarsia 2962:Profiles 2887:Dovetail 2826:Geometry 2665:Hand saw 2650:Crosscut 2635:Circular 2630:Chainsaw 2577:Holdfast 2242:Rosewood 2174:American 2169:Mahogany 2141:Jelutong 2111:Hornbeam 2076:Cocobolo 2071:Chestnut 1986:Andiroba 1798:Millwork 1763:Intarsia 1758:Fretwork 1753:Ébéniste 1682:Glossary 1585:Archived 1526:25598633 1460:Archived 1396:Archived 1349:Archived 1299:26703529 1248:28344469 1199:24613274 1163:23999722 1112:23999722 1054:Archived 997:52120407 989:30158623 926:cite web 916:29 March 873:(n.d.). 805:Archived 574:(මහෝගනි) 571:mahogani 554:Thenkani 551:Tamil - 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Index

Big-leaf Mahogany

Conservation status
Endangered
IUCN 3.1
Scientific classification
Edit this classification
Plantae
Tracheophytes
Angiosperms
Eudicots
Rosids
Sapindales
Meliaceae
Swietenia
Binomial name
King
Historic range of big-leaf mahogany in South America
Current range of big-leaf mahogany in South America
Synonyms
plant
Meliaceae
mahogany
Swietenia
Swietenia mahagoni
Swietenia humilis
naturalized
Philippines
Singapore
Hawaii

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