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Biological effects of high-energy visible light

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413:(IOL). The IOL may be designed to filter out equal, more or less UV light than the natural lens (have a higher or lower cutoff), and therefore attenuate or accentuate the blue-light hazard function. The effects of long term exposure of UV, violet and blue light on the retina can then be studied. However, it has been argued that IOLs that remove more blue light than natural lenses negatively affect color vision and the circadian rhythm while not offering significant photoprotection. Systematic reviews found no evidence of any effect in IOLs filtering blue light, and none provided any reliable statistical evidence to suggest any effect regarding contrast sensitivity, macular degeneration, vision, color-discrimination or sleep disturbances. One study claimed a large difference in observed fluorescein angiography examinations and observed markedly less "progression of abnormal fundus autofluorescence"; however the authors failed to discuss the fact that the excitation beam is filtered light between 465 and 490 nm, is largely blocked by blue light filtering IOLs but not clear IOLs present in the control patients. 326:, a light sensitive protein that absorbs maximally at 480 nm, but has at least 10% efficiency in the range of 450-540 nm. The periodic (daily) exposure to sunlight generally tunes the circadian rhythm to a 24-hour cycle. However, exposure to light sources that excite melanopsin in the retina during nighttime can interfere with the circadian rhythm. Harvard Health Publishing asserts that exposure to blue light at night has a strong negative effect on sleep. The aforementioned ANSES report "highlights disruptive effects to biological rhythms and sleep, linked to exposure to even very low levels of blue light in the evening or at night, particularly via screens". A 2016 press release by the 187: 432:
simultaneously. To be effective against blue-light hazard, the glasses must be worn continuously, especially during the day when exposure is higher. However, to force blue-light exposure that mimics the normal daylight cycle, the glasses must only be worn at night, when the exposure is already quite low from a photoprotective perspective. Regardless, some evidence shows that lenses that block blue light before bedtime may be particularly useful for people with
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as green light at 555 nm. For comparison, UV-A at 380  nm (V(λ)=0.000 039) requires 25 641 times the amount of radiometric energy to be perceived at the same intensity as green, three orders of magnitude greater than blue LEDs. Studies often compare animal trials using identical luminous
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Aggressive advertisements may contribute to the incorrect public perception of the purported dangers of blue light. Even when research has shown no evidence to support the use of blue-blocking filters as a clinical treatment for digital eye strain, ophthalmic lens manufacturers continue to market
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The efficacy of blue-blocking lenses in blocking blue light is not disputed, but whether typical exposure to blue light is hazardous enough to require blue blocking lenses is highly disputed. One problem with the glasses is that they cannot achieve positive outcomes in blue-light hazard and sleep
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LEDs, white light from lighting is generally produced by pairing a blue LED emitting primarily near 450 nm combined with a phosphor for down-conversion of some of the blue light to longer wavelengths, which then combine to form white light. This is often considered “the next generation of
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Lenses that filter blue light have been on the market for a long time in the form of brown-, orange-, and yellow-tinted sunglasses. These tinted lenses were popular for the belief that they enhanced contrast and depth perception, but after early research showing the health risks of blue light
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highlights short-term effects on the retina linked to intense exposure to blue LED light, and long-term effects linked to the onset of age-related macular degeneration. Although few studies have examined occupational causes of macular degeneration, they show that long-term sunlight exposure,
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receptors in the eye. This suppresses daytime melatonin, enabling wakefulness. Working in blue-free light (aka yellow light) for long periods of time disrupts circadian patterns because there is no melatonin suppression during the day, and reduced melatonin rebound at night.
233:. Increasingly, blue blocking filters are being designed into glasses to avoid blue light's purported negative effects. However, there is no good evidence that filtering blue light with spectacles has any effect on eye health, eye strain, sleep quality or vision quality. 384:
Apple's and Microsoft's operating systems and even the preset settings of standalone computer monitors include options to reduce blue-light emissions by adjusting color temperature to a warmer gamut. However, these settings dramatically reduce the size of the
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Concerns over exposure to blue light has predicated several solutions to decreasing blue light exposure, including disabling or attenuating blue LEDs in displays, color shifting displays towards yellow, or wearing glasses that filter out blue light.
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Nagai, H.; Hirano, Y.; Yasukawa, T.; Morita, H.; Nozaki, M.; Wolf-Schnurrbusch, U.; Wolf, S.; Ogura, Y. (September 2015). "Prevention of increased abnormal fundus autofluorescence with blue light-filtering intraocular lenses".
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and white LED lamps have 5 times greater impact on circadian sleep rhythms than conventional street lamps. However, they also indicate that street lamp brightness is more strongly correlated to sleep outcomes.
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of blue light, so exposure to high levels of blue light is not a new or unique phenomenon despite the relatively recent emergence of LED display technologies. While LED displays emit white by exciting all
49: 448:, though less beneficial for healthy sleepers. The small number of studies contributing to those conclusions to date have methodological flaws or risks of bias, so further research is warranted. 1412:
Vagge, Aldo; Ferro Desideri, Lorenzo; Del Noce, Chiara; Di Mola, Ilaria; Sindaco, Daniele; Traverso, Carlo E. (2021-03-18). "Blue light filtering ophthalmic lenses: A systematic review".
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Barbaric J, Abbott R, Posadzki P, Car M, Gunn LH, Layton AM, Majeed A, Car J (January 2018). "Light therapies for acne: abridged Cochrane systematic review including GRADE assessments".
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assesses the photobiological safety of light sources. A proposed standard, IEC 62778, provides additional guidance in the assessment of blue-light hazard of all lighting products.
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Blue LEDs, particularly those used in white LEDs, operate at around 450 nm, where V(λ)=0.038. This means that blue light at 450 nm requires about 25 times the
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Margrain TH, Boulton M, Marshall J, Sliney DH (September 2004). "Do blue light filters confer protection against age-related macular degeneration?".
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The circadian rhythm is a mechanism that regulates sleep patterns. One of the primary factors affecting the circadian rhythm is the excitation of
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Mainster, Martin A.; Turner, Patricia L. (May 2010). "Blue-blocking IOLs Decrease Photoreception Without Providing Significant Photoprotection".
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color blindness, thereby sacrificing the usability of the displays. The filters can be set on a schedule to activate only when the sun is down.
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published its position on the low risk of blue-light hazard resulting from the use of LED technology in general lighting bulbs in April 2019.
1805:"Interventions to reduce short-wavelength ("blue") light exposure at night and their effects on sleep: A systematic review and meta-analysis" 949: 1775: 521:
Glaz r-Hockstein C, Dunaief JL (January 2006). "Could blue light-blocking lenses decrease the risk of age-related macular degeneration?".
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was banned by the Advertising Standards Authority for making claims that blue light glasses could improve sleep without substantiation.
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Anderson, Kenneth V; Coyle, Frances P; O'Stben, W. Keith (1 May 1972). "Retinal degeneration produced by low-intensity colored light".
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Ham, William T.; Mueller, Harold A.; Sliney, David H. (11 March 1976). "Retinal sensitivity to damage from short wavelength light".
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flux rather than radiance meaning comparative levels of perceived light at different frequencies rather than total emitted energy.
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Bullough, John D.; Bierman, Andrew; Rea, Mark S. (3 April 2019). "Evaluating the blue-light hazard from solid state lighting".
691: 1320: 1062:"LEDs & blue light | Anses - Agence Nationale de sécurité Sanitaire de l'alimentation, de l'environnement et du travail" 841:"LEDs & blue light | Anses - Agence nationale de sécurité Sanitaire de l'alimentation, de l'environnement et du travail" 1913: 1958: 1587: 1000:"A "Melanopic" Spectral Efficiency Function Predicts the Sensitivity of Melanopsin Photoreceptors to Polychromatic Lights" 1091: 491: 441: 327: 1465:"Artificial, blue-light filtering lenses in the eye for protecting the macula (back of the eye) after cataract surgery" 914: 2026: 468: 1180: 647:
US. Department of energy. (2013). Solid-State Lighting Technology Fact Sheet (Optical Safety of LEDs). Available at:
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fined them ÂŁ40,000. Boots Opticians sold the lenses for a ÂŁ20 markup. Trevor Warburton, speaking on behalf of the UK
2031: 2021: 768:"Light-induced retinal damage using different light sources, protocols and rat strains reveals LED phototoxicity" 1804: 998:
Enezi, Jazi al; Revell, Victoria; Brown, Timothy; Wynne, Jonathan; Schlangen, Luc; Lucas, Robert (August 2011).
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specifically its blue-light component, is associated with macular degeneration in outdoor workers. However, the
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Shechter, Ari; Quispe, Kristal A; Mizhquiri Barbecho, Jennifer S; Slater, Cody; Falzon, Louise (June 4, 2020).
1047: 456: 90: 2016: 745:"Kay & Laby;tables of physical & chemical constants;General physics;SubSection: 2.5.3 Photometry" 253:), as well as the blue appearance (higher color temperature) compared with traditional sources. However, 667: 363:
As with other types of light therapy, there is no good evidence that blue light is of use in treating
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concludes that there are negative effects on the circadian rhythm from the unrestrained use of LED
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https://www.lightingglobal.org/wp-content/uploads/bsk-pdf-manager/82_opticalsafety_fact-sheet.pdf
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Scott AM, Stehlik P, Clark J, Zhang D, Yang Z, Hoffmann T, Mar CD, Glasziou P (November 2019).
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for their unsubstantiated claims regarding their line of blue-light filtering lenses; and the
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stated: "...current evidence does not support making claims that they prevent eye disease.".
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Hovis, Jeffery K.; Lovasik, John V.; Cullen, Anthony P.; Kothe, Angela C. (October 1989).
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Blue LEDs are often the target of blue-light research due to the increasing prevalence of
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exposure, became more popular for the purported health benefits of blocking blue light.
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Singh S, Keller PR, Busija L, McMillan P, Makrai E, Lawrenson JG, et al. (2023).
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Blue light is essential for regulating the circadian rhythm, because it stimulates
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illumination” as SSL technology dramatically reduces energy resource requirements.
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Tsankov, Plamen Ts. (2020). "Lighting Technologies". In Pavlovic, Tomislav (ed.).
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Rosenfield, Mark (2016). "Computer vision syndrome (aka digital eye strain)".
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Blue light, a type of high-energy light, is part of the visible light spectrum
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Agency for Food, Environmental and Occupational Health & Safety (ANSES)
76: 1752: 1654: 1557: 722: 1697: 867:"Macular degeneration and occupational risk factors: a systematic review" 433: 254: 250: 217:, which has a number of purported negative biological effects, namely on 973:"The IEC addresses characterization of the blue light hazard (MAGAZINE)" 1878: 829:. International Journal of Ophthalmology, Vol. 10, No. 2. Feb 18, 2017. 422: 1937:"BOOTS OPTICIANS FINED ÂŁ40,000 OVER MISLEADING BLUE LIGHT ADVERTISING" 1776:"There's no evidence that blue‑light blocking glasses help with sleep" 1217: 1087:"AMA adopts guidance to reduce harm from high intensity street lights" 1689: 1274: 222: 915:"Position Statement on the Blue Light Hazard (April 23, 2019) | CIE" 386: 185: 1572: 1181:"Blue-light glasses don't help with eye strain, major study says" 445: 206: 944:. Cham, Switzerland: Springer Nature Switzerland. p. 261. 871:
International Archives of Occupational and Environmental Health
355:, but there is no robust evidence to support this hypothesis. 263: 117: 70: 29: 865:
Modenese, Alberto; Gobba, Fabriziomaria (September 6, 2018).
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International Journal of Occupational Safety and Ergonomics
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Beaulé, C.; Robinson, B.; Lamont, E. W.; Amir, S. (2003).
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Downie, L. E.; Busija, L.; Keller, P. R. (May 22, 2018).
1957:. Advertising Standards Authority. Archived from 661:"Product family datasheet:Cree® XLamp® XM-L LEDs" 1910:"Optical chain fined $ 69,000 for misleading ad" 725:. International Organization for Standardization 1321:"Set your display for night time in Windows 10" 452:them as lenses that reduce digital eye strain. 351:Blue light has been implicated as the cause of 389:of the display, as they essentially simulate 8: 1469:The Cochrane Database of Systematic Reviews 1115:"Melanopsin in the circadian timing system" 692:"Technical Data Sheet X42182(Z-power LEDs)" 64:Learn how and when to remove these messages 1861:M, Rosenfield; RT, Li; NT, Kirsch (2020). 1515:Journal of Cataract and Refractive Surgery 474:In July 2022, a Gamer Advantage advert on 423:Glasses § Blue-light blocking glasses 1830: 1820: 1488: 1282: 1225: 1050:. Harvard Health Letter. August 13, 2018. 1015: 890: 624: 174:Learn how and when to remove this message 156:Learn how and when to remove this message 101:of all important aspects of the article. 513: 1981:"Gamer Advantage's Blue-Light Glasses" 274:(energy) for one to perceive the same 97:Please consider expanding the lead to 1798: 1796: 941:The Sun and Photovoltaic Technologies 7: 1575:. Ophthalmic Photographers' Society. 1560:. Ophthalmic Photographers' Society. 1307:"How to use Night Shift on your Mac" 140:Please help consolidate the article. 2037:Sleeplessness and sleep deprivation 1420:(7). Informa UK Limited: 541–548. 787:10.1016/j.neuroscience.2016.10.015 747:. National Physical Laboratory; UK 25: 1908:Woodley, Matthew (May 31, 2017). 1586:Clark, B. a. J. (November 1969). 1391:10.1016/j.survophthal.2009.07.006 1119:Journal of Molecular Neuroscience 666:. Cree. p. 4. Archived from 45:This article has multiple issues. 1737:10.1097/00006324-198910000-00004 1604:10.1097/00006324-196911000-00004 697:. pp. 12–13. Archived from 570:10.1016/j.preteyeres.2004.05.001 535:10.1097/00006982-200601000-00001 231:age-related macular degeneration 122: 75: 34: 1935:Powell, Selina (May 26, 2017). 465:Advertising Standards Authority 89:may be too short to adequately 53:or discuss these issues on the 1481:10.1002/14651858.CD011977.pub2 1179:LaMotte, Sandee (2023-08-17). 617:10.1002/14651858.CD013244.pub2 99:provide an accessible overview 1: 1822:10.1093/sleepadvances/zpaa002 1426:10.1080/08820538.2021.1900283 1348:10.1080/10803548.2017.1375172 1004:Journal of Biological Rhythms 409:is replaced with a synthetic 201:) is short-wave light in the 1725:Optometry and Vision Science 1647:10.1016/0014-4886(72)90149-5 1592:Optometry and Vision Science 1571:Bennett, Timothy J. (2017). 1556:Bennett, Timothy J. (2017). 1092:American Medical Association 1048:"Blue Light Has A Dark Side" 492:Fluorescent lamps and health 442:delayed sleep phase disorder 328:American Medical Association 1558:"Equipment & Technique" 469:Association of Optometrists 304:The international standard 2053: 1588:"Color in Sunglass Lenses" 1573:"Fluorescein Fundamentals" 1527:10.1016/j.jcrs.2015.01.017 605:Cochrane Database Syst Rev 523:Retina (Philadelphia, Pa.) 420: 417:Blue light blocking lenses 315: 292:A 2019 report by France's 209:band from 400 to 450  1912:. Insight. Archived from 1475:(5). Cochrane: CD011977. 1414:Seminars in Ophthalmology 883:10.1007/s00420-018-1355-y 195:High-energy visible light 1017:10.1177/0748730411409719 135:too many section headers 1379:Survey of Ophthalmology 766:Krigel, Arthur (2016). 457:General Optical Council 1987:. 2022. Archived from 1635:Experimental Neurology 257:has a relatively high 191: 1951:"Gamer Advantage LLC" 1867:Work (Reading, Mass.) 1265:(Systematic review). 1162:Optometry in Practice 405:, the opaque natural 283:Physiological effects 229:), which can lead to 189: 1985:Truth in Advertising 1916:on September 3, 2019 497:Phase response curve 247:Solid-state lighting 1682:1976Natur.260..153H 1131:10.1385/JMN:21:1:73 371:Blue light blocking 27:Blue-light toxicity 2027:Technology hazards 1939:. Optometry Today. 1879:10.3233/WOR-203086 558:Prog Retin Eye Res 397:Intraocular lenses 353:digital eye strain 192: 1676:(5547): 153–155. 1323:. March 13, 2019. 1309:. March 13, 2019. 1218:10.1111/bjd.15495 1208:(Meta-analysis). 979:. 15 January 2014 951:978-3-030-22402-8 502:Ultraviolet light 288:Blue light hazard 227:blue-light hazard 184: 183: 176: 166: 165: 158: 116: 115: 68: 18:Blue-light hazard 16:(Redirected from 2044: 2032:Circadian rhythm 2022:Optical spectrum 2001: 2000: 1998: 1996: 1977: 1971: 1970: 1968: 1966: 1947: 1941: 1940: 1932: 1926: 1925: 1923: 1921: 1905: 1899: 1898: 1858: 1852: 1851: 1849: 1847: 1834: 1824: 1800: 1791: 1790: 1788: 1786: 1771: 1765: 1764: 1716: 1710: 1709: 1690:10.1038/260153a0 1665: 1659: 1658: 1630: 1624: 1623: 1583: 1577: 1576: 1568: 1562: 1561: 1553: 1547: 1546: 1509: 1503: 1502: 1492: 1460: 1454: 1453: 1409: 1403: 1402: 1374: 1368: 1367: 1331: 1325: 1324: 1317: 1311: 1310: 1303: 1297: 1296: 1286: 1275:10.1370/afm.2445 1254: 1248: 1247: 1229: 1201: 1195: 1194: 1192: 1191: 1176: 1170: 1169: 1157: 1151: 1150: 1110: 1104: 1103: 1101: 1100: 1083: 1077: 1076: 1074: 1073: 1068:. 13 August 2019 1058: 1052: 1051: 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