5052:
1071:
837:
600:
In June 2020, the FDA approved an updated prescription label for brolucizumab that included additional safety information—specifically including the characterization of adverse events, retinal vasculitis and retinal vascular occlusion, as part of the spectrum of intraocular inflammation observed in
575:
The FDA approved brolucizumab based on evidence from two clinical trials (Trial 1/ NCT02307682 and Trial 2/NCT02434328) of 1459 participants, 50–97 years old, with wet AMD. The trials were conducted at 336 sites in the United States, Canada, Central and South
America, European countries, Israel,
1416:
565:(BCVA) from baseline to week 48. Furthermore, brolucizumab demonstrated superiority to aflibercept in key secondary endpoint measures of disease activity in wet age-related macular degeneration, a leading cause of blindness in two head-to-head pivotal Phase III studies.
1409:
525:
The most common side effects are reduced visual acuity, cataract (clouding of the lens in the eye), conjunctival haemorrhage (bleeding at the front of the eye) and vitreous floaters (spots in the vision). The most serious side effects are blindness,
1402:
865:
541:
A (VEGF-A). VEGF-A is a protein that makes blood vessels grow and leak fluid and blood, damaging the macula. By blocking VEGF-A, brolucizumab reduces the growth of the blood vessels and controls the leakage and swelling.
592:
In
February 2020, the American Society of Retina Specialists reported side effects of brolucizumab, specifically in 14 cases of retinal vasculitis reported in people using brolucizumab, 11 of the cases were
857:
652:
243:
2118:
2014:
1157:
1296:
Eason AB, Sin SH, Szabó E, Phillips DJ, Droste M, Shamshiev A, et al. (2018). "Abstract 4: Antitumor activity of DLX1008, a single chain antibody fragment binding to VEGF-A, in
707:
198:
1126:
776:
1096:
4033:
1056:
2111:
557:
Brolucizumab successfully completed phase III development in wet age-related macular degeneration (AMD) meeting the primary efficacy endpoint of non-inferiority to
1209:
4993:
2007:
96:
4649:
3797:
649:
899:
3414:
2104:
3472:
36:
677:
4334:
4024:
2000:
3629:
1149:
2614:
2297:
1343:
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5012:
4962:
4933:
4880:
3367:
3234:
1958:
4691:
4687:
4683:
4679:
2232:
2216:
923:"HAWK and HARRIER: Phase 3, Multicenter, Randomized, Double-Masked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration"
519:
65:
2960:
2879:
2746:
2663:
699:
4675:
964:"Single-Chain Antibody Fragment VEGF Inhibitor RTH258 for Neovascular Age-Related Macular Degeneration: A Randomized Controlled Study"
538:
822:
4364:
3483:
3043:
2654:
610:
1118:
2312:
2256:
2247:
1088:
737:
768:
4886:
228:
128:
858:"Novartis receives FDA approval for Beovu, offering wet AMD patients vision gains and greater fluid reductions vs aflibercept"
5072:
4973:
4949:
4089:
3645:
3508:
1394:
41:
625:
Non-ophthalmology indications are under investigation, under the name DLX1008. DLX1008 is under preclinical development for
1045:
4939:
5077:
4983:
3379:
3261:
3251:
2041:
1489:
1250:
1217:
1051:
893:
569:
551:
409:
147:
4329:
1975:
1425:
4354:
1359:"Antitumor Activity of DLX1008, an Anti-VEGFA Antibody Fragment with Low Picomolar Affinity, in Human Glioma Models"
5042:
4968:
2794:
614:
4349:
4876:
1264:
816:
601:
HAWK (NCT02307682) and HARRIER (NCT02434328) clinical trials and noted in the original prescribing information.
3060:
2976:
2895:
2762:
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1614:
1609:
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2494:
362:
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2407:
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1992:
1963:
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669:
184:
4339:
4944:
4560:
4464:
4324:
4084:
3503:
2489:
2127:
1870:
1267:(2014). "International nonproprietary names for pharmaceutical substances (INN): proposed INN: list 112".
730:"Beovu 120 mg/ml solution for injection in pre-filled syringe - Summary of Product Characteristics (SmPC)"
597:
that can lead to vision loss. Novartis responded with a statement standing behind the efficacy of Beovu.
5018:
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1337:
353:
4958:
4344:
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1238:
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2402:
530:(an infection inside the eye), retinal artery occlusion (blockage of the artery in the retina) and
308:
48:
29:
3135:
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2130:
1748:
1647:
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1325:
1033:
1012:
594:
572:(FDA) approved brolucizumab injection for the treatment of wet age-related macular degeneration.
531:
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4275:
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78:
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4169:
4139:
3619:
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3306:
3145:
3090:
1357:
Szabó E, Phillips DJ, Droste M, Marti A, Kretzschmar T, Shamshiev A, et al. (May 2018).
317:
4822:
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1655:
1370:
1309:
1276:
975:
934:
454:
3346:
962:
Holz FG, Dugel PU, Weissgerber G, Hamilton R, Silva R, Bandello F, et al. (May 2016).
921:
Dugel PU, Koh A, Ogura Y, Jaffe GJ, Schmidt-Erfurth U, Brown DM, et al. (April 2019).
418:
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841:
562:
120:
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1329:
576:
Turkey, Australia, New
Zealand, Japan, South Korea, Singapore, Taiwan, and Vietnam.
5028:
4998:
4737:
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4374:
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1007:
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518:
among others, is a humanized single-chain antibody fragment for the treatment of
4988:
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4827:
4777:
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1588:
1548:
1475:
1089:"Novartis Responds to ASRS Note Raising Safety Concerns With Wet AMD Drug Beovu"
558:
114:
1313:
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4772:
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2519:
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2199:
2189:
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1831:
1811:
1790:
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1689:
1684:
1578:
1573:
1563:
1558:
1553:
1538:
1533:
1504:
1470:
1032:
for "Efficacy and Safety of RTH258 Versus
Aflibercept - Study 2 (HARRIER)" at
493:
393:
1321:
1239:
Statement On A Nonproprietary Name
Adopted By The USAN Council - Brolucizumab
22:
4832:
4802:
4797:
4792:
4787:
4782:
4762:
4752:
4742:
4732:
4424:
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4255:
4014:
4009:
4004:
3994:
3989:
3984:
3974:
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3737:
3722:
3717:
3707:
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3571:
3336:
3256:
3175:
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3010:
2949:
2939:
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2731:
2529:
2524:
2514:
2422:
2412:
2397:
2372:
2367:
2357:
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2347:
2070:
1856:
1836:
1780:
1768:
1758:
1733:
1699:
1632:
1593:
1583:
1568:
1454:
1449:
1375:
1358:
100:
53:
1384:
1150:"Novartis stands behind Beovu's safety, benefits after vision-loss warning"
1011:
for "Efficacy and Safety of RTH258 Versus
Aflibercept - Study 1 (HAWK)" at
989:
948:
579:
Brolucizumab was approved for use in the
European Union in February 2020.
5003:
4722:
4379:
3979:
3969:
3949:
3884:
3853:
3822:
3786:
3692:
3682:
3029:
2509:
2452:
2362:
2322:
1775:
1119:"Novartis' hot new eye drug Beovu tied to potential vision loss: experts"
373:
142:
1281:
382:
4978:
4399:
3864:
3266:
2227:
328:
60:
4891:
4555:
4444:
4369:
4074:
4069:
3493:
3488:
3442:
3438:
3434:
3430:
3426:
3422:
3418:
3070:
2609:
2287:
1180:"Novartis provides update on use and safety of Beovu (brolucizumab)"
537:
Brolucizumab was designed to attach to and block a substance called
1210:"BRIEF-U.S. FDA Approves Novartis' Updated Beovu Label - Statement"
438:
4923:
4919:
4915:
4911:
4907:
4903:
4899:
4895:
4610:
4509:
4184:
4124:
3938:
3661:
3657:
3653:
3649:
3140:
3004:
2923:
2919:
2818:
2814:
2810:
2806:
2715:
2711:
2562:
1187:
1074:
This article incorporates text from this source, which is in the
840:
This article incorporates text from this source, which is in the
4394:
3000:
2996:
2992:
2988:
2984:
2980:
2915:
2911:
2907:
2903:
2899:
2802:
2798:
2790:
2786:
2782:
2778:
2774:
2770:
2766:
2707:
2703:
2699:
2695:
2691:
2687:
2683:
2635:
2631:
2627:
2593:
2558:
2539:
1434:
429:
287:
262:
2100:
1996:
1398:
275:
137:
1428:
for bone, musculoskeletal, circulatory, and neurologic systems
852:
850:
237:
169:
1363:
The
Journal of Pharmacology and Experimental Therapeutics
1300:
preclinical models of Kaposi sarcoma and glioblastoma".
250:
4994:
Pituitary adenylate cyclase-activating peptide (PACAP)
5040:
534:(separation of the retina from the back of the eye).
4861:
4648:
4543:
4312:
4052:
4043:
4023:
3937:
3914:
3883:
3852:
3821:
3785:
3776:
3628:
3471:
3404:
3366:
3233:
3224:
3042:
3019:
2959:
2878:
2745:
2662:
2653:
2592:
2538:
2451:
2255:
2246:
2215:
2137:
2039:
1928:
1907:
1898:
1878:
1869:
1799:
1741:
1732:
1646:
1623:
1602:
1526:
1517:
1497:
1488:
1463:
1442:
1433:
492:
453:
448:
428:
408:
392:
372:
361:
352:
327:
307:
302:
227:
222:
197:
183:
157:
127:
113:
95:
87:
77:
72:
59:
47:
35:
28:
4940:Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)
3798:Glial cell line-derived neurotrophic factor (GDNF)
3451:Cleavage products/derivatives with unknown target:
888:"Drug Approval Package: Beovu (brolucizumab-dbll)"
520:neovascular (wet) age-related macular degeneration
763:
761:
759:
757:
755:
4974:Macrophage-stimulating protein (MSP; HLP, HGFLP)
568:In October 2019, Novartis announced that the US
341:
2615:Heparin-binding EGF-like growth factor (HB-EGF)
2298:Heparin-binding EGF-like growth factor (HB-EGF)
316:
1022:
1020:
1001:
999:
5026:Additional growth factor receptor modulators:
2112:
2008:
1410:
8:
3380:Insulin-like growth factor-2 (somatomedin A)
3262:Insulin-like growth factor-2 (somatomedin A)
3252:Insulin-like growth factor-1 (somatomedin C)
806:
804:
802:
800:
798:
796:
794:
146:
21:
700:"Summary Basis of Decision (SBD) for Beovu"
295:In general: ℞ (Prescription only)
4049:
3782:
3230:
2659:
2252:
2119:
2105:
2097:
2015:
2001:
1993:
1904:
1875:
1738:
1523:
1494:
1439:
1417:
1403:
1395:
1374:
1280:
979:
938:
769:"Beovu- brolucizumab injection, solution"
417:
4984:Migration-stimulating factor (MSF; PRG4)
5047:
2313:Transforming growth factor alpha (TGFα)
642:
381:
119:
4887:Connective tissue growth factor (CTGF)
1335:
868:from the original on 13 September 2021
740:from the original on 24 September 2020
20:
4950:Hepatoma-derived growth factor (HDGF)
1059:from the original on 17 November 2019
902:from the original on 17 November 2019
105:
7:
1160:from the original on 1 November 2020
1099:from the original on 4 November 2021
825:from the original on 8 November 2020
210:
66:Vascular endothelial growth factor A
779:from the original on 9 January 2021
550:Brolucizumab is approved by the US
437:
332:
1342:: CS1 maint: overridden setting (
680:from the original on 8 August 2024
539:vascular endothelial growth factor
91:brolucizumab-dbll, RTH258, DLX1008
14:
1129:from the original on 27 July 2021
710:from the original on 23 June 2023
611:International Nonproprietary Name
561:in mean change in best corrected
5050:
4969:Leukemia inhibitory factor (LIF)
1069:
835:
554:(FDA) for use in ophthalmology.
471:
465:
4137:Negative allosteric modulators:
1186:. 28 April 2020. Archived from
4455:Gossypetin (3,5,7,8,3',4'-HHF)
3646:Platelet-derived growth factor
1216:. 11 June 2020. Archived from
1046:"Drug Trials Snapshots: BEOVU"
483:
477:
459:
42:Single-chain variable fragment
1:
4661:Placental growth factor (PGF)
1148:Sagonowsky E (2 March 2020).
4945:Glia maturation factor (GMF)
3454:Glypromate (GPE, (1-3)IGF-1)
1251:American Medical Association
1052:Food and Drug Administration
981:10.1016/j.ophtha.2015.12.030
940:10.1016/j.ophtha.2019.04.017
894:Food and Drug Administration
595:occlusive retinal vasculitis
570:Food and Drug Administration
552:Food and Drug Administration
670:"Beovu Product information"
5094:
4877:Colony-stimulating factors
4869:Additional growth factors:
1314:10.1158/1538-7445.AM2018-4
615:United States Adopted Name
449:Chemical and physical data
4225:SNA-120 (pegylated K252a)
3397:(against IGF-1 and IGF-2)
3359:(against IGF-1 and IGF-2)
1953:
1265:World Health Organization
817:European Medicines Agency
3061:Hepatocyte growth factor
2620:Neuregulins (heregulins)
2551:Neuregulins (heregulins)
2495:Trastuzumab duocarmazine
2208:(against angiopoietin 2)
2202:(against angiopoietin 3)
2408:Depatuxizumab mafodotin
1376:10.1124/jpet.117.246249
258: / Schedule D
5031:(neurotrophin mixture)
5019:Wnt signaling proteins
4700:Allosteric modulators:
4420:Norwogonin (5,7,8-THF)
2640:5 (tomoregulin, TMEFF)
2490:Trastuzumab deruxtecan
2128:Growth factor receptor
1871:Angiogenesis inhibitor
1244:15 August 2016 at the
1026:Clinical trial number
1005:Clinical trial number
650:Medicine registrations
514:sold under trade name
5073:Monoclonal antibodies
4959:T-cell growth factors
3216:Telisotuzumab vedotin
2500:Trastuzumab emtansine
659:Australian Government
3544:EVT-901 (SAR-127963)
3277:Mecasermin rinfabate
1308:(13 Supplement): 4.
1269:WHO Drug Information
1125:. 24 February 2020.
1095:. 25 February 2020.
821:. 10 December 2019.
655:28 June 2023 at the
609:Brolucizumab is the
5078:Ophthalmology drugs
898:. 4 November 2019.
775:. 13 January 2020.
706:. 23 October 2014.
583:Society and culture
271:(Prescription only)
246:(Prescription only)
30:Monoclonal antibody
25:
16:Pharmaceutical drug
4710:Kinase inhibitors:
4573:Kinase inhibitors:
4472:Kinase inhibitors:
4147:Kinase inhibitors:
3962:Kinase inhibitors:
3922:Kinase inhibitors:
3903:Kinase inhibitors:
3872:Kinase inhibitors:
3841:Kinase inhibitors:
3810:Kinase inhibitors:
3670:Kinase inhibitors:
3284:Kinase inhibitors:
3078:Kinase inhibitors:
2867:Kinase inhibitors:
2860:Aprutumab ixadotin
2507:Kinase inhibitors:
2320:Kinase inhibitors:
2177:Kinase inhibitors:
2042:neovascularisation
1980:Never to phase III
1749:Anti-amyloid drugs
1190:on 17 October 2021
1055:. 7 October 2019.
1034:ClinicalTrials.gov
1013:ClinicalTrials.gov
532:retinal detachment
5038:
5037:
4644:
4643:
4405:N-Acetylserotonin
4304:ReN-1820 (TrkAd5)
3933:
3932:
3467:
3466:
3412:Binding proteins:
3071:Dihexa (PNB-0408)
3038:
3037:
2649:
2648:
2563:6 (neuroglycan C)
2283:EGF (urogastrone)
2261:
2094:
2093:
2028:vascular disorder
2024:Ophthalmologicals
1990:
1989:
1949:
1948:
1894:
1893:
1865:
1864:
1728:
1727:
1513:
1512:
1484:
1483:
676:. 25 April 2012.
509:
508:
291:
279:
266:
253:
241:
173:
140:
5085:
5055:
5054:
5053:
5046:
4850:Decoy receptors:
4823:Alacizumab pegol
4301:Decoy receptors:
4050:
3955:Stem cell factor
3896:Persephin (PSPN)
3834:Neurturin (NRTN)
3783:
3620:LEVI-04 (p75-Fc)
3617:Decoy receptors:
3231:
2660:
2259:
2253:
2121:
2114:
2107:
2098:
2017:
2010:
2003:
1994:
1905:
1876:
1739:
1656:Alacizumab pegol
1524:
1495:
1440:
1419:
1412:
1405:
1396:
1389:
1388:
1378:
1354:
1348:
1347:
1341:
1333:
1293:
1287:
1286:
1284:
1261:
1255:
1236:
1230:
1229:
1227:
1225:
1206:
1200:
1199:
1197:
1195:
1176:
1170:
1169:
1167:
1165:
1145:
1139:
1138:
1136:
1134:
1115:
1109:
1108:
1106:
1104:
1085:
1079:
1073:
1072:
1068:
1066:
1064:
1042:
1036:
1024:
1015:
1003:
994:
993:
983:
959:
953:
952:
942:
918:
912:
911:
909:
907:
884:
878:
877:
875:
873:
854:
845:
839:
838:
834:
832:
830:
808:
789:
788:
786:
784:
765:
750:
749:
747:
745:
736:. 9 March 2020.
726:
720:
719:
717:
715:
696:
690:
689:
687:
685:
666:
660:
647:
504:
502:
485:
479:
473:
467:
461:
441:
421:
385:
365:
345:
335:
334:
320:
289:
286:
277:
274:
264:
261:
252:
249:
239:
236:
214:
171:
168:
150:
139:
136:
123:
109:
26:
24:
5093:
5092:
5088:
5087:
5086:
5084:
5083:
5082:
5063:
5062:
5061:
5051:
5049:
5041:
5039:
5034:
4979:Midkine (NEGF2)
4857:
4640:
4539:
4308:
4246:ABT-110 (PG110)
4039:
4019:
3929:
3910:
3879:
3848:
3817:
3772:
3624:
3562:ABT-110 (PG110)
3463:
3400:
3362:
3220:
3034:
3015:
2955:
2952:(against FGF23)
2874:
2741:
2645:
2588:
2534:
2447:
2258:
2242:
2211:
2133:
2125:
2095:
2090:
2035:
2021:
1991:
1986:
1985:
1970:Clinical trials
1945:
1924:
1890:
1861:
1795:
1724:
1642:
1619:
1598:
1509:
1490:Musculoskeletal
1480:
1459:
1429:
1423:
1393:
1392:
1356:
1355:
1351:
1334:
1302:Cancer Research
1295:
1294:
1290:
1263:
1262:
1258:
1246:Wayback Machine
1237:
1233:
1223:
1221:
1220:on 11 June 2020
1208:
1207:
1203:
1193:
1191:
1178:
1177:
1173:
1163:
1161:
1147:
1146:
1142:
1132:
1130:
1117:
1116:
1112:
1102:
1100:
1087:
1086:
1082:
1070:
1062:
1060:
1044:
1043:
1039:
1025:
1018:
1004:
997:
961:
960:
956:
920:
919:
915:
905:
903:
886:
885:
881:
871:
869:
856:
855:
848:
836:
828:
826:
810:
809:
792:
782:
780:
767:
766:
753:
743:
741:
728:
727:
723:
713:
711:
698:
697:
693:
683:
681:
668:
667:
663:
657:Wayback Machine
648:
644:
639:
623:
607:
590:
588:Safety concerns
585:
548:
528:endophthalmitis
500:
498:
488:
482:
476:
470:
464:
444:
424:
404:
388:
368:
348:
331:
323:
298:
218:
186:
179:
160:
153:
17:
12:
11:
5:
5091:
5089:
5081:
5080:
5075:
5065:
5064:
5060:
5059:
5036:
5035:
5033:
5032:
5022:
5021:
5016:
5009:Thrombopoietin
5006:
5001:
4996:
4991:
4986:
4981:
4976:
4971:
4966:
4952:
4947:
4942:
4937:
4930:Erythropoietin
4927:
4889:
4884:
4874:
4872:Adrenomedullin
4865:
4863:
4859:
4858:
4856:
4855:
4846:
4845:
4840:
4835:
4830:
4825:
4816:
4815:
4810:
4805:
4800:
4795:
4790:
4785:
4780:
4775:
4770:
4765:
4760:
4755:
4750:
4745:
4740:
4735:
4730:
4725:
4720:
4715:
4706:
4705:
4696:
4695:
4673:
4668:
4663:
4654:
4652:
4646:
4645:
4642:
4641:
4639:
4638:
4633:
4628:
4623:
4618:
4613:
4608:
4603:
4598:
4593:
4588:
4583:
4578:
4569:
4568:
4563:
4558:
4549:
4547:
4541:
4540:
4538:
4537:
4532:
4527:
4522:
4517:
4512:
4507:
4502:
4497:
4492:
4487:
4482:
4477:
4468:
4467:
4458:
4457:
4452:
4447:
4438:
4437:
4432:
4427:
4422:
4417:
4412:
4407:
4402:
4397:
4392:
4387:
4382:
4377:
4372:
4367:
4362:
4357:
4352:
4347:
4342:
4337:
4335:4'-DMA-7,8-DHF
4332:
4327:
4318:
4316:
4310:
4309:
4307:
4306:
4297:
4296:
4284:
4283:
4278:
4273:
4268:
4263:
4258:
4253:
4248:
4229:
4228:
4222:
4217:
4212:
4207:
4202:
4197:
4192:
4187:
4182:
4177:
4172:
4167:
4162:
4157:
4152:
4143:
4142:
4133:
4132:
4127:
4122:
4117:
4108:
4107:
4102:
4097:
4095:Gambogic amide
4092:
4087:
4082:
4077:
4072:
4067:
4058:
4056:
4047:
4041:
4040:
4038:
4037:
4029:
4027:
4021:
4020:
4018:
4017:
4012:
4007:
4002:
3997:
3992:
3987:
3982:
3977:
3972:
3967:
3958:
3957:
3952:
3943:
3941:
3935:
3934:
3931:
3930:
3928:
3927:
3918:
3916:
3912:
3911:
3909:
3908:
3899:
3898:
3889:
3887:
3881:
3880:
3878:
3877:
3868:
3867:
3865:Artemin (ARTN)
3858:
3856:
3850:
3849:
3847:
3846:
3837:
3836:
3827:
3825:
3819:
3818:
3816:
3815:
3806:
3805:
3800:
3791:
3789:
3780:
3774:
3773:
3771:
3770:
3765:
3760:
3751:
3750:
3745:
3740:
3735:
3730:
3725:
3720:
3715:
3710:
3705:
3700:
3695:
3690:
3685:
3680:
3675:
3666:
3665:
3643:
3634:
3632:
3626:
3625:
3623:
3622:
3613:
3612:
3600:
3599:
3594:
3589:
3584:
3579:
3574:
3569:
3564:
3552:
3551:
3546:
3541:
3536:
3527:
3526:
3521:
3516:
3511:
3506:
3501:
3496:
3491:
3486:
3477:
3475:
3469:
3468:
3465:
3464:
3462:
3461:
3456:
3447:
3446:
3408:
3406:
3402:
3401:
3399:
3398:
3392:
3383:
3382:
3372:
3370:
3364:
3363:
3361:
3360:
3354:
3349:
3344:
3339:
3334:
3329:
3324:
3319:
3310:
3309:
3304:
3299:
3294:
3289:
3280:
3279:
3274:
3269:
3264:
3259:
3254:
3249:
3239:
3237:
3228:
3222:
3221:
3219:
3218:
3213:
3208:
3203:
3198:
3193:
3188:
3179:
3178:
3173:
3168:
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3123:
3118:
3113:
3108:
3103:
3098:
3093:
3088:
3083:
3074:
3073:
3064:
3063:
3058:
3048:
3046:
3040:
3039:
3036:
3035:
3033:
3032:
3023:
3021:
3017:
3016:
3014:
3013:
3008:
2974:
2965:
2963:
2957:
2956:
2954:
2953:
2943:
2942:
2937:
2932:
2927:
2893:
2884:
2882:
2876:
2875:
2873:
2872:
2863:
2862:
2857:
2848:
2847:
2842:
2837:
2832:
2827:
2822:
2760:
2751:
2749:
2743:
2742:
2740:
2739:
2734:
2729:
2724:
2719:
2677:
2668:
2666:
2657:
2651:
2650:
2647:
2646:
2644:
2643:
2617:
2612:
2607:
2598:
2596:
2590:
2589:
2587:
2586:
2581:
2576:
2567:
2566:
2544:
2542:
2536:
2535:
2533:
2532:
2527:
2522:
2517:
2512:
2503:
2502:
2497:
2492:
2487:
2482:
2477:
2468:
2467:
2457:
2455:
2449:
2448:
2446:
2445:
2440:
2435:
2430:
2425:
2420:
2415:
2410:
2405:
2400:
2391:
2390:
2385:
2380:
2375:
2370:
2365:
2360:
2355:
2350:
2345:
2340:
2335:
2330:
2325:
2316:
2315:
2310:
2305:
2300:
2295:
2290:
2285:
2280:
2275:
2265:
2263:
2250:
2244:
2243:
2241:
2240:
2235:
2230:
2221:
2219:
2213:
2212:
2210:
2209:
2203:
2193:
2192:
2187:
2182:
2173:
2172:
2170:Angiopoietin 3
2167:
2165:Angiopoietin 2
2158:
2157:
2155:Angiopoietin 4
2152:
2150:Angiopoietin 1
2143:
2141:
2135:
2134:
2126:
2124:
2123:
2116:
2109:
2101:
2092:
2091:
2089:
2088:
2083:
2078:
2073:
2068:
2063:
2058:
2053:
2047:
2045:
2037:
2036:
2022:
2020:
2019:
2012:
2005:
1997:
1988:
1987:
1984:
1983:
1982:
1981:
1978:
1967:
1961:
1955:
1954:
1951:
1950:
1947:
1946:
1944:
1943:
1938:
1932:
1930:
1926:
1925:
1923:
1922:
1917:
1911:
1909:
1902:
1896:
1895:
1892:
1891:
1889:
1888:
1882:
1880:
1873:
1867:
1866:
1863:
1862:
1860:
1859:
1854:
1849:
1844:
1839:
1834:
1829:
1824:
1819:
1814:
1809:
1803:
1801:
1797:
1796:
1794:
1793:
1788:
1783:
1778:
1773:
1772:
1771:
1766:
1761:
1756:
1745:
1743:
1736:
1730:
1729:
1726:
1725:
1723:
1722:
1717:
1712:
1707:
1702:
1697:
1692:
1687:
1682:
1677:
1672:
1667:
1658:
1652:
1650:
1644:
1643:
1641:
1640:
1635:
1629:
1627:
1621:
1620:
1618:
1617:
1612:
1606:
1604:
1600:
1599:
1597:
1596:
1591:
1586:
1581:
1576:
1571:
1566:
1561:
1556:
1551:
1546:
1541:
1536:
1530:
1528:
1521:
1515:
1514:
1511:
1510:
1508:
1507:
1501:
1499:
1492:
1486:
1485:
1482:
1481:
1479:
1478:
1473:
1467:
1465:
1461:
1460:
1458:
1457:
1452:
1446:
1444:
1437:
1431:
1430:
1424:
1422:
1421:
1414:
1407:
1399:
1391:
1390:
1369:(2): 422–429.
1349:
1288:
1256:
1231:
1201:
1171:
1140:
1110:
1080:
1037:
1016:
995:
954:
913:
879:
846:
790:
751:
721:
691:
661:
641:
640:
638:
635:
627:Kaposi sarcoma
622:
619:
613:(INN) and the
606:
603:
589:
586:
584:
581:
547:
544:
507:
506:
496:
490:
489:
486:
480:
474:
468:
462:
457:
451:
450:
446:
445:
443:
442:
434:
432:
426:
425:
423:
422:
414:
412:
406:
405:
403:
402:
398:
396:
390:
389:
387:
386:
378:
376:
370:
369:
367:
366:
358:
356:
350:
349:
347:
346:
338:
336:
325:
324:
322:
321:
313:
311:
305:
304:
300:
299:
297:
296:
293:
284:
272:
259:
247:
233:
231:
225:
224:
220:
219:
217:
216:
203:
201:
195:
194:
189:
187:administration
181:
180:
178:
177:
175:
165:
163:
155:
154:
152:
151:
133:
131:
125:
124:
117:
111:
110:
103:
93:
92:
89:
85:
84:
81:
75:
74:
70:
69:
63:
57:
56:
51:
45:
44:
39:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
5090:
5079:
5076:
5074:
5071:
5070:
5068:
5058:
5048:
5044:
5030:
5027:
5024:
5023:
5020:
5017:
5014:
5010:
5007:
5005:
5002:
5000:
4997:
4995:
4992:
4990:
4987:
4985:
4982:
4980:
4977:
4975:
4972:
4970:
4967:
4964:
4960:
4956:
4953:
4951:
4948:
4946:
4943:
4941:
4938:
4935:
4931:
4928:
4925:
4921:
4917:
4913:
4909:
4905:
4901:
4897:
4893:
4890:
4888:
4885:
4882:
4878:
4875:
4873:
4870:
4867:
4866:
4864:
4860:
4854:
4851:
4848:
4847:
4844:
4841:
4839:
4836:
4834:
4831:
4829:
4826:
4824:
4821:
4818:
4817:
4814:
4811:
4809:
4806:
4804:
4801:
4799:
4796:
4794:
4791:
4789:
4786:
4784:
4781:
4779:
4776:
4774:
4771:
4769:
4766:
4764:
4761:
4759:
4756:
4754:
4751:
4749:
4746:
4744:
4741:
4739:
4736:
4734:
4731:
4729:
4726:
4724:
4721:
4719:
4716:
4714:
4711:
4708:
4707:
4704:
4703:Cyclotraxin B
4701:
4698:
4697:
4693:
4689:
4685:
4681:
4677:
4674:
4672:
4669:
4667:
4664:
4662:
4659:
4656:
4655:
4653:
4651:
4647:
4637:
4634:
4632:
4629:
4627:
4624:
4622:
4619:
4617:
4616:Larotrectinib
4614:
4612:
4609:
4607:
4604:
4602:
4599:
4597:
4594:
4592:
4589:
4587:
4584:
4582:
4579:
4577:
4574:
4571:
4570:
4567:
4564:
4562:
4559:
4557:
4554:
4551:
4550:
4548:
4546:
4542:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4515:Larotrectinib
4513:
4511:
4508:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4481:
4478:
4476:
4473:
4470:
4469:
4466:
4463:
4460:
4459:
4456:
4453:
4451:
4450:Cyclotraxin B
4448:
4446:
4443:
4440:
4439:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4386:
4383:
4381:
4378:
4376:
4373:
4371:
4368:
4366:
4363:
4361:
4360:Amitriptyline
4358:
4356:
4353:
4351:
4348:
4346:
4343:
4341:
4338:
4336:
4333:
4331:
4328:
4326:
4323:
4320:
4319:
4317:
4315:
4311:
4305:
4302:
4299:
4298:
4295:
4292:
4289:
4286:
4285:
4282:
4279:
4277:
4274:
4272:
4269:
4267:
4264:
4262:
4259:
4257:
4254:
4252:
4249:
4247:
4244:
4240:
4237:
4236:Against TrkA:
4234:
4231:
4230:
4226:
4223:
4221:
4218:
4216:
4213:
4211:
4208:
4206:
4203:
4201:
4198:
4196:
4193:
4191:
4190:Larotrectinib
4188:
4186:
4183:
4181:
4178:
4176:
4173:
4171:
4168:
4166:
4163:
4161:
4158:
4156:
4153:
4151:
4148:
4145:
4144:
4141:
4138:
4135:
4134:
4131:
4128:
4126:
4123:
4121:
4120:Dexamethasone
4118:
4116:
4113:
4110:
4109:
4106:
4103:
4101:
4098:
4096:
4093:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4073:
4071:
4068:
4066:
4065:Amitriptyline
4063:
4060:
4059:
4057:
4055:
4051:
4048:
4046:
4042:
4035:
4031:
4030:
4028:
4026:
4022:
4016:
4013:
4011:
4008:
4006:
4003:
4001:
3998:
3996:
3993:
3991:
3988:
3986:
3983:
3981:
3978:
3976:
3973:
3971:
3968:
3966:
3963:
3960:
3959:
3956:
3953:
3951:
3948:
3945:
3944:
3942:
3940:
3936:
3926:
3923:
3920:
3919:
3917:
3913:
3907:
3904:
3901:
3900:
3897:
3894:
3891:
3890:
3888:
3886:
3882:
3876:
3873:
3870:
3869:
3866:
3863:
3860:
3859:
3857:
3855:
3851:
3845:
3842:
3839:
3838:
3835:
3832:
3829:
3828:
3826:
3824:
3820:
3814:
3811:
3808:
3807:
3804:
3801:
3799:
3796:
3793:
3792:
3790:
3788:
3784:
3781:
3779:
3775:
3769:
3766:
3764:
3761:
3759:
3756:
3753:
3752:
3749:
3746:
3744:
3741:
3739:
3736:
3734:
3731:
3729:
3726:
3724:
3721:
3719:
3716:
3714:
3711:
3709:
3706:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3684:
3681:
3679:
3676:
3674:
3671:
3668:
3667:
3663:
3659:
3655:
3651:
3647:
3644:
3642:
3639:
3636:
3635:
3633:
3631:
3627:
3621:
3618:
3615:
3614:
3611:
3608:
3605:
3602:
3601:
3598:
3595:
3593:
3590:
3588:
3585:
3583:
3580:
3578:
3575:
3573:
3570:
3568:
3565:
3563:
3560:
3557:
3554:
3553:
3550:
3547:
3545:
3542:
3540:
3539:Dexamethasone
3537:
3535:
3532:
3529:
3528:
3525:
3522:
3520:
3517:
3515:
3512:
3510:
3507:
3505:
3502:
3500:
3497:
3495:
3492:
3490:
3487:
3485:
3482:
3479:
3478:
3476:
3474:
3470:
3460:
3457:
3455:
3452:
3449:
3448:
3444:
3440:
3436:
3432:
3428:
3424:
3420:
3416:
3413:
3410:
3409:
3407:
3403:
3396:
3393:
3391:
3388:
3385:
3384:
3381:
3377:
3374:
3373:
3371:
3369:
3365:
3358:
3355:
3353:
3350:
3348:
3345:
3343:
3340:
3338:
3335:
3333:
3330:
3328:
3325:
3323:
3320:
3318:
3315:
3312:
3311:
3308:
3305:
3303:
3300:
3298:
3295:
3293:
3290:
3288:
3285:
3282:
3281:
3278:
3275:
3273:
3270:
3268:
3265:
3263:
3260:
3258:
3255:
3253:
3250:
3248:
3247:des(1-3)IGF-1
3244:
3241:
3240:
3238:
3236:
3232:
3229:
3227:
3223:
3217:
3214:
3212:
3211:Telisotuzumab
3209:
3207:
3204:
3202:
3199:
3197:
3194:
3192:
3189:
3187:
3184:
3181:
3180:
3177:
3174:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3124:
3122:
3119:
3117:
3114:
3112:
3109:
3107:
3104:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3084:
3082:
3079:
3076:
3075:
3072:
3069:
3068:Potentiators:
3066:
3065:
3062:
3059:
3057:
3053:
3050:
3049:
3047:
3045:
3041:
3031:
3028:
3025:
3024:
3022:
3018:
3012:
3009:
3006:
3002:
2998:
2994:
2990:
2986:
2982:
2978:
2975:
2973:
2970:
2967:
2966:
2964:
2962:
2958:
2951:
2948:
2945:
2944:
2941:
2938:
2936:
2933:
2931:
2930:Selpercatinib
2928:
2925:
2921:
2917:
2913:
2909:
2905:
2901:
2897:
2894:
2892:
2889:
2886:
2885:
2883:
2881:
2877:
2871:
2868:
2865:
2864:
2861:
2858:
2856:
2853:
2850:
2849:
2846:
2843:
2841:
2838:
2836:
2835:Selpercatinib
2833:
2831:
2828:
2826:
2823:
2820:
2816:
2812:
2808:
2804:
2800:
2796:
2792:
2788:
2784:
2780:
2776:
2772:
2768:
2764:
2761:
2759:
2756:
2753:
2752:
2750:
2748:
2744:
2738:
2735:
2733:
2730:
2728:
2727:Selpercatinib
2725:
2723:
2720:
2717:
2713:
2709:
2705:
2701:
2697:
2693:
2689:
2685:
2681:
2678:
2676:
2673:
2670:
2669:
2667:
2665:
2661:
2658:
2656:
2652:
2641:
2637:
2633:
2629:
2625:
2621:
2618:
2616:
2613:
2611:
2608:
2606:
2603:
2600:
2599:
2597:
2595:
2591:
2585:
2582:
2580:
2577:
2575:
2572:
2569:
2568:
2564:
2560:
2556:
2552:
2549:
2546:
2545:
2543:
2541:
2537:
2531:
2528:
2526:
2523:
2521:
2518:
2516:
2513:
2511:
2508:
2505:
2504:
2501:
2498:
2496:
2493:
2491:
2488:
2486:
2483:
2481:
2478:
2476:
2473:
2470:
2469:
2466:
2462:
2459:
2458:
2456:
2454:
2450:
2444:
2441:
2439:
2436:
2434:
2431:
2429:
2426:
2424:
2421:
2419:
2416:
2414:
2411:
2409:
2406:
2404:
2403:Depatuxizumab
2401:
2399:
2396:
2393:
2392:
2389:
2386:
2384:
2381:
2379:
2376:
2374:
2371:
2369:
2366:
2364:
2361:
2359:
2356:
2354:
2351:
2349:
2346:
2344:
2341:
2339:
2336:
2334:
2331:
2329:
2326:
2324:
2321:
2318:
2317:
2314:
2311:
2309:
2306:
2304:
2301:
2299:
2296:
2294:
2291:
2289:
2286:
2284:
2281:
2279:
2276:
2274:
2270:
2267:
2266:
2264:
2262:
2254:
2251:
2249:
2245:
2239:
2236:
2234:
2231:
2229:
2226:
2223:
2222:
2220:
2218:
2214:
2207:
2204:
2201:
2198:
2195:
2194:
2191:
2188:
2186:
2183:
2181:
2178:
2175:
2174:
2171:
2168:
2166:
2163:
2160:
2159:
2156:
2153:
2151:
2148:
2145:
2144:
2142:
2140:
2136:
2132:
2129:
2122:
2117:
2115:
2110:
2108:
2103:
2102:
2099:
2087:
2084:
2082:
2079:
2077:
2074:
2072:
2069:
2067:
2064:
2062:
2059:
2057:
2054:
2052:
2049:
2048:
2046:
2043:
2038:
2033:
2029:
2025:
2018:
2013:
2011:
2006:
2004:
1999:
1998:
1995:
1979:
1977:
1974:
1973:
1971:
1968:
1965:
1962:
1960:
1957:
1956:
1952:
1942:
1941:Landogrozumab
1939:
1937:
1934:
1933:
1931:
1927:
1921:
1918:
1916:
1913:
1912:
1910:
1906:
1903:
1901:
1900:Growth factor
1897:
1887:
1884:
1883:
1881:
1877:
1874:
1872:
1868:
1858:
1855:
1853:
1850:
1848:
1845:
1843:
1840:
1838:
1835:
1833:
1830:
1828:
1825:
1823:
1820:
1818:
1815:
1813:
1810:
1808:
1805:
1804:
1802:
1798:
1792:
1789:
1787:
1784:
1782:
1779:
1777:
1774:
1770:
1767:
1765:
1762:
1760:
1757:
1755:
1752:
1751:
1750:
1747:
1746:
1744:
1740:
1737:
1735:
1731:
1721:
1718:
1716:
1713:
1711:
1710:Ralpancizumab
1708:
1706:
1703:
1701:
1698:
1696:
1693:
1691:
1688:
1686:
1683:
1681:
1678:
1676:
1673:
1671:
1668:
1666:
1662:
1659:
1657:
1654:
1653:
1651:
1649:
1645:
1639:
1636:
1634:
1631:
1630:
1628:
1626:
1622:
1616:
1613:
1611:
1608:
1607:
1605:
1601:
1595:
1592:
1590:
1587:
1585:
1582:
1580:
1577:
1575:
1572:
1570:
1567:
1565:
1562:
1560:
1557:
1555:
1552:
1550:
1547:
1545:
1544:Ascrinvacumab
1542:
1540:
1537:
1535:
1532:
1531:
1529:
1525:
1522:
1520:
1516:
1506:
1503:
1502:
1500:
1496:
1493:
1491:
1487:
1477:
1474:
1472:
1469:
1468:
1466:
1462:
1456:
1453:
1451:
1448:
1447:
1445:
1441:
1438:
1436:
1432:
1427:
1420:
1415:
1413:
1408:
1406:
1401:
1400:
1397:
1386:
1382:
1377:
1372:
1368:
1364:
1360:
1353:
1350:
1345:
1339:
1331:
1327:
1323:
1319:
1315:
1311:
1307:
1303:
1299:
1292:
1289:
1283:
1278:
1274:
1270:
1266:
1260:
1257:
1253:
1252:
1247:
1243:
1240:
1235:
1232:
1219:
1215:
1211:
1205:
1202:
1189:
1185:
1181:
1175:
1172:
1159:
1155:
1151:
1144:
1141:
1128:
1124:
1120:
1114:
1111:
1098:
1094:
1090:
1084:
1081:
1077:
1076:public domain
1058:
1054:
1053:
1047:
1041:
1038:
1035:
1031:
1030:
1023:
1021:
1017:
1014:
1010:
1009:
1002:
1000:
996:
991:
987:
982:
977:
974:(5): 1080–9.
973:
969:
968:Ophthalmology
965:
958:
955:
950:
946:
941:
936:
932:
928:
927:Ophthalmology
924:
917:
914:
901:
897:
895:
889:
883:
880:
867:
863:
859:
853:
851:
847:
843:
842:public domain
824:
820:
818:
813:
807:
805:
803:
801:
799:
797:
795:
791:
778:
774:
770:
764:
762:
760:
758:
756:
752:
739:
735:
731:
725:
722:
709:
705:
704:Health Canada
701:
695:
692:
679:
675:
674:Health Canada
671:
665:
662:
658:
654:
651:
646:
643:
636:
634:
632:
628:
620:
618:
616:
612:
604:
602:
598:
596:
587:
582:
580:
577:
573:
571:
566:
564:
563:visual acuity
560:
555:
553:
545:
543:
540:
535:
533:
529:
523:
521:
517:
513:
497:
495:
491:
458:
456:
452:
447:
440:
436:
435:
433:
431:
427:
420:
416:
415:
413:
411:
407:
400:
399:
397:
395:
391:
384:
380:
379:
377:
375:
371:
364:
360:
359:
357:
355:
351:
344:
340:
339:
337:
330:
326:
319:
315:
314:
312:
310:
306:
301:
294:
292: Rx-only
285:
283:
273:
270:
260:
257:
248:
245:
235:
234:
232:
230:
226:
221:
213:
208:
205:
204:
202:
200:
196:
193:
190:
188:
182:
176:
167:
166:
164:
162:
156:
149:
144:
135:
134:
132:
130:
126:
122:
118:
116:
112:
108:
104:
102:
98:
94:
90:
86:
82:
80:
76:
73:Clinical data
71:
67:
64:
62:
58:
55:
52:
50:
46:
43:
40:
38:
34:
31:
27:
19:
5029:Cerebrolysin
5025:
4999:Pleiotrophin
4955:Interleukins
4868:
4849:
4819:
4738:Fruquintinib
4728:Cabozantinib
4709:
4699:
4657:
4621:Lestaurtinib
4572:
4552:
4520:Lestaurtinib
4471:
4461:
4442:Antagonists:
4441:
4375:Deoxygedunin
4330:3,7,8,2'-THF
4321:
4300:
4291:Against NGF:
4290:
4287:
4243:Against NGF:
4242:
4235:
4232:
4195:Lestaurtinib
4146:
4136:
4130:Testosterone
4112:Antagonists:
4111:
4061:
3961:
3946:
3921:
3902:
3892:
3871:
3861:
3840:
3830:
3809:
3794:
3754:
3669:
3637:
3616:
3607:Against NGF:
3606:
3603:
3559:Against NGF:
3558:
3555:
3549:Testosterone
3531:Antagonists:
3530:
3480:
3450:
3411:
3386:
3375:
3352:Teprotumumab
3313:
3283:
3242:
3191:Ficlatuzumab
3186:Emibetuzumab
3182:
3136:JNJ-38877605
3106:Cabozantinib
3077:
3067:
3056:Fosgonimeton
3051:
3026:
2968:
2946:
2887:
2870:Infigratinib
2866:
2851:
2754:
2671:
2605:Betacellulin
2601:
2584:Seribantumab
2570:
2547:
2506:
2471:
2465:Unknown/none
2464:
2460:
2394:
2319:
2278:Betacellulin
2273:Amphiregulin
2268:
2260:(ErbB1/HER1)
2224:
2196:
2176:
2162:Antagonists:
2161:
2146:
2139:Angiopoietin
2066:Brolucizumab
2065:
1936:Domagrozumab
1827:Galcanezumab
1822:Fremanezumab
1807:Bapineuzumab
1764:Gantenerumab
1705:Idarucizumab
1695:Etaracizumab
1680:Caplacizumab
1675:Brolucizumab
1674:
1366:
1362:
1352:
1338:cite journal
1305:
1301:
1297:
1291:
1282:10665/331100
1272:
1268:
1259:
1249:
1234:
1222:. Retrieved
1218:the original
1213:
1204:
1192:. Retrieved
1188:the original
1183:
1174:
1162:. Retrieved
1154:FiercePharma
1153:
1143:
1131:. Retrieved
1123:FiercePharma
1122:
1113:
1101:. Retrieved
1093:Eyewire News
1092:
1083:
1061:. Retrieved
1049:
1040:
1027:
1006:
971:
967:
957:
933:(1): 72–84.
930:
926:
916:
904:. Retrieved
891:
882:
870:. Retrieved
861:
827:. Retrieved
815:
812:"Beovu EPAR"
781:. Retrieved
772:
742:. Retrieved
733:
724:
712:. Retrieved
703:
694:
682:. Retrieved
673:
664:
645:
631:glioblastoma
624:
608:
599:
591:
578:
574:
567:
556:
549:
536:
524:
515:
512:Brolucizumab
511:
510:
318:1531589-13-5
229:Legal status
223:Legal status
192:Intravitreal
148:Brolucizumab
129:License data
23:Brolucizumab
18:
4989:Oncomodulin
4853:Aflibercept
4843:Ranibizumab
4838:Ramucirumab
4828:Bevacizumab
4820:Antibodies:
4778:Regorafenib
4718:Altiratinib
4631:ONO-5390556
4601:Entrectinib
4576:Altiratinib
4530:ONO-5390556
4500:Entrectinib
4475:Altiratinib
4261:Frunevetmab
4233:Antibodies:
4210:ONO-5390556
4175:Entrectinib
4150:Altiratinib
4105:Tavilermide
4000:Quizartinib
3939:SCF (c-Kit)
3763:Ramucirumab
3755:Antibodies:
3728:Quizartinib
3678:Avapritinib
3641:Becaplermin
3577:Frunevetmab
3556:Antibodies:
3459:Trofinetide
3390:Dusigitumab
3387:Antibodies:
3342:Robatumumab
3332:Figitumumab
3327:Dalotuzumab
3322:Cixutumumab
3314:Antibodies:
3206:Rilotumumab
3201:Onartuzumab
3196:Flanvotumab
3183:Antibodies:
3151:PF-04217903
3081:Altiratinib
3044:HGF (c-Met)
2947:Antibodies:
2852:Antibodies:
2574:Duligotumab
2571:Antibodies:
2485:Trastuzumab
2475:Ertumaxomab
2472:Antibodies:
2443:Zalutumumab
2438:Panitumumab
2433:Nimotuzumab
2428:Necitumumab
2418:Imgatuzumab
2395:Antibodies:
2378:Osimertinib
2343:Dacomitinib
2238:Dapiclermin
2197:Antibodies:
2180:Altiratinib
2086:Verteporfin
2081:Ranibizumab
2061:Bevacizumab
2051:Aflibercept
1966:from market
1920:Trevogrumab
1886:Ranibizumab
1852:Solanezumab
1847:Semorinemab
1842:Refanezumab
1817:Eptinezumab
1720:Vanucizumab
1715:Tadocizumab
1670:Bococizumab
1665:Ranibizumab
1661:Bevacizumab
1638:Volociximab
1589:Ramucirumab
1549:Bentracimab
1519:Circulatory
1476:Romosozumab
1426:Monoclonals
1063:17 November
1029:NCT02434328
1008:NCT02307682
906:17 November
559:aflibercept
505: g·mol
303:Identifiers
115:MedlinePlus
88:Other names
79:Trade names
5067:Categories
4808:Vandetanib
4773:Rebastinib
4768:Pegaptanib
4758:Nintedanib
4748:Lenvatinib
4713:Agerafenib
4666:Ripretinib
4591:CH-7057288
4490:CH-7057288
4355:7,8,3'-THF
4350:7,8,2'-THF
4276:Ranevetmab
4266:Fulranumab
4220:Rebastinib
4165:CH-7057288
4080:Cenegermin
3965:Agerafenib
3925:Agerafenib
3906:Vandetanib
3875:Vandetanib
3844:Vandetanib
3813:Vandetanib
3758:Olaratumab
3733:Ripretinib
3713:Nintedanib
3698:Lenvatinib
3688:Crenolanib
3673:Agerafenib
3592:Ranevetmab
3582:Fulranumab
3499:Cenegermin
3473:LNGF (p75)
3395:Xentuzumab
3357:Xentuzumab
3302:NVP-AEW541
3297:NVP-ADW742
3292:Linsitinib
3287:BMS-754807
3272:Mecasermin
3171:Tivantinib
3161:PHA-665752
3156:PF-2341066
3126:Golvatinib
3116:Crizotinib
3111:Capmatinib
3101:BMS-777607
3096:Amuvatinib
2972:Ersofermin
2935:Sprifermin
2891:Ersofermin
2840:Sprifermin
2830:Repifermin
2825:Palifermin
2758:Ersofermin
2737:Velafermin
2722:Repifermin
2675:Ersofermin
2594:ErbB4/HER4
2579:Patritumab
2540:ErbB3/HER3
2520:Mubritinib
2480:Pertuzumab
2453:ErbB2/HER2
2383:Vandetanib
2338:Canertinib
2333:Brigatinib
2328:Agerafenib
2308:Nepidermin
2303:Murodermin
2293:Epiregulin
2248:EGF (ErbB)
2206:Nesvacumab
2200:Evinacumab
2190:Rebastinib
2131:modulators
2076:Pegaptanib
2056:Anecortave
1915:Bimagrumab
1832:Ozanezumab
1812:Crenezumab
1791:Opicinumab
1786:Fulranumab
1754:Aducanumab
1734:Neurologic
1690:Emicizumab
1685:Demcizumab
1579:Nesvacumab
1574:Inclacumab
1564:Evolocumab
1559:Evinacumab
1554:Enoticumab
1539:Alirocumab
1534:Abelacimab
1505:Stamulumab
1471:Blosozumab
1275:(4): 493.
872:16 October
637:References
494:Molar mass
419:XSZ53G39H5
394:ChemSpider
354:IUPHAR/BPS
309:CAS Number
4833:Icrucumab
4813:WHI-P 154
4803:Tivozanib
4798:Toceranib
4793:Sunitinib
4788:Sorafenib
4783:Semaxanib
4763:Pazopanib
4753:Motesanib
4743:Lapatinib
4733:Cediranib
4671:Telbermin
4658:Agonists:
4606:GZ-389988
4586:CE-245677
4553:Agonists:
4505:GZ-389988
4485:CE-245677
4385:Diosmetin
4322:Agonists:
4288:Aptamers:
4281:Tanezumab
4256:Fasinumab
4200:Milciclib
4180:GZ-389988
4160:CE-245677
4062:Agonists:
4015:Toceranib
4010:Sunitinib
4005:Sorafenib
3995:Pazopanib
3990:Nilotinib
3985:Masitinib
3975:Dasatinib
3947:Agonists:
3893:Agonists:
3862:Agonists:
3831:Agonists:
3803:Liatermin
3795:Agonists:
3778:RET (GFL)
3768:Tovetumab
3748:Toceranib
3743:Sorafenib
3738:Sunitinib
3723:Radotinib
3718:Pazopanib
3708:Motesanib
3703:Masitinib
3638:Agonists:
3604:Aptamers:
3597:Tanezumab
3572:Fasinumab
3481:Agonists:
3337:Ganitumab
3257:IGF-1 LR3
3176:Volitinib
3131:INCB28060
3121:Foretinib
3027:Agonists:
3011:Trafermin
2969:Agonists:
2950:Burosumab
2940:Trafermin
2888:Agonists:
2855:Aprutumab
2845:Trafermin
2807:10 (KGF2)
2755:Agonists:
2732:Trafermin
2712:10 (KGF2)
2672:Agonists:
2602:Agonists:
2548:Agonists:
2530:Tucatinib
2525:Neratinib
2515:Lapatinib
2423:Matuzumab
2413:Futuximab
2398:Cetuximab
2388:WHI-P 154
2373:Neratinib
2368:Lapatinib
2358:Grandinin
2353:Gefitinib
2348:Erlotinib
2225:Agonists:
2185:CE-245677
2147:Agonists:
2071:Faricimab
2026:: ocular
1976:Phase III
1964:Withdrawn
1929:Humanized
1879:Humanized
1857:Tanezumab
1837:Ponezumab
1800:Humanized
1781:Fasinumab
1769:Lecanemab
1759:Donanemab
1700:Faricimab
1648:Humanized
1633:Abciximab
1615:Imciromab
1610:Biciromab
1594:Rinucumab
1584:Orticumab
1569:Icrucumab
1464:Humanized
1455:Denosumab
1450:Burosumab
1322:0008-5472
343:252827371
185:Routes of
159:Pregnancy
107:Monograph
101:Drugs.com
54:Humanized
5057:Medicine
5015:instead)
5004:Renalase
4965:instead)
4936:instead)
4883:instead)
4723:Axitinib
4692:D (FIGF)
4636:PLX-7486
4626:ONO-4474
4581:AZD-6918
4535:PLX-7486
4525:ONO-4474
4480:AZD-6918
4462:Ligands:
4380:Deprenyl
4340:7,3'-DHF
4271:MEDI-578
4251:ASP-6294
4215:PLX-7486
4205:ONO-4474
4155:AZD-6918
4115:ALE-0540
4036:instead.
3980:Imatinib
3970:Axitinib
3950:Ancestim
3915:Unsorted
3693:Imatinib
3683:Axitinib
3587:MEDI-578
3567:ASP-6294
3534:ALE-0540
3376:Agonists
3317:AVE-1642
3243:Agonists
3166:SU-11274
3052:Agonists
3030:FGF15/19
3020:Unsorted
2985:2 (bFGF)
2904:2 (bFGF)
2771:2 (bFGF)
2688:2 (bFGF)
2510:Afatinib
2461:Agonists
2363:Icotinib
2323:Afatinib
2269:Agonists
2030:agents (
1776:Erenumab
1625:Chimeric
1385:29507055
1330:81317833
1242:Archived
1194:27 April
1184:Novartis
1164:27 April
1158:Archived
1133:27 April
1127:Archived
1103:27 April
1097:Archived
1057:Archived
990:26906165
949:30986442
900:Archived
866:Archived
862:Novartis
823:Archived
777:Archived
773:DailyMed
738:Archived
708:Archived
678:Archived
653:Archived
621:Research
374:DrugBank
199:ATC code
161:category
143:DailyMed
4892:Ephrins
4596:DS-6051
4495:DS-6051
4400:LM22A-4
4390:DMAQ-B1
4345:7,8-DHF
4325:3,7-DHF
4294:RBM-004
4239:GBR-900
4170:DS-6051
4140:VM-902A
3610:RBM-004
3307:OSl-906
3267:Insulin
3146:MK-2461
3091:AMG-458
2228:Axokine
1298:in vivo
1224:11 June
1214:Reuters
617:(USAN)
546:History
522:(AMD).
455:Formula
383:DB14864
329:PubChem
254::
215:)
209: (
207:S01LA06
174: D
145::
121:a620001
68:(VEGFA)
5043:Portal
4862:Others
4556:BNN-20
4445:ANA-12
4370:BNN-20
4090:DHEA-S
4075:BNN-27
4070:BNN-20
3509:DHEA-S
3494:BNN-27
3489:BNN-20
3405:Others
2610:Epigen
2288:Epigen
2044:agents
1959:WHO-EM
1383:
1328:
1320:
988:
947:
714:29 May
684:29 May
439:D11083
282:℞-only
280:
267:
256:℞-only
242:
141:
61:Target
49:Source
5011:(see
4961:(see
4932:(see
4879:(see
4611:K252a
4510:K252a
4185:K252a
4125:FX007
3885:GFRα4
3854:GFRα3
3823:GFRα2
3787:GFRα1
3415:IGFBP
3368:IGF-2
3347:R1507
3235:IGF-1
3141:K252a
2961:FGFR4
2880:FGFR3
2747:FGFR2
2664:FGFR1
1908:Human
1742:Human
1603:Mouse
1527:Human
1498:Human
1443:Human
1326:S2CID
1050:U.S.
896:(FDA)
892:U.S.
829:3 May
819:(EMA)
783:3 May
744:3 May
734:(emc)
605:Names
516:Beovu
83:Beovu
5013:here
4963:here
4934:here
4881:here
4676:VEGF
4650:VEGF
4566:NT-3
4561:DHEA
4545:TrkC
4465:DHEA
4435:TDP6
4415:NT-4
4410:NT-3
4395:HIOC
4365:BDNF
4314:TrkB
4085:DHEA
4054:TrkA
4034:here
4032:See
4025:TGFβ
3630:PDGF
3524:NT-4
3519:NT-3
3504:DHEA
3484:BDNF
2233:CNTF
2217:CNTF
2040:Anti
2032:S01L
1435:Bone
1381:PMID
1344:link
1318:ISSN
1226:2020
1196:2020
1166:2020
1135:2020
1105:2020
1065:2019
986:PMID
945:PMID
908:2019
874:2019
831:2020
785:2020
746:2020
716:2022
686:2022
629:and
469:1768
463:1164
430:KEGG
410:UNII
401:none
363:8713
97:AHFS
37:Type
4430:R13
4100:NGF
4045:Trk
3514:NGF
3226:IGF
3086:AM7
2977:FGF
2896:FGF
2797:),
2795:KGF
2763:FGF
2680:FGF
2655:FGF
2257:EGF
1371:doi
1367:365
1310:doi
1277:hdl
976:doi
972:123
935:doi
931:127
503:.17
501:281
481:372
475:310
333:CID
269:POM
212:WHO
5069::
4924:B3
4922:,
4920:B2
4918:,
4916:B1
4914:,
4912:A5
4910:,
4908:A4
4906:,
4904:A3
4902:,
4900:A2
4898:,
4896:A1
4690:,
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4682:,
4425:R7
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244:S4
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