423:, an important advancement in Cryptosporidium biology. He has designed many algorithms and computational protocols to extract structural information from NMR data, and used that information to compute structures of globular proteins and symmetric homo-oligomers. A distinct feature of his algorithms is that they use less data, and provide complexity-theoretic guarantees on time and space (See, e.g., B. R. Donald and J. Martin. "Automated NMR Assignment and Protein Structure Determination using Sparse Dipolar Coupling Constraints."
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the structures of biomedically significant proteins. For example, his subgroup algorithm CRANS (Acta
Crystallogr. D 2004; J. Biol. Chem. 2003), which identifies cross-rotation peaks consistent with non-crystallographic symmetry, was used in the structure determination of the enzyme dihydrofolate reductase-thymidylate synthase (DHFR-TS) from
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which have been successfully tested experimentally in the wet lab. The protein design algorithms attempt to incorporate additional molecular flexibility into the design process by using ensembles and continuously flexible rotamers and backbones. Donald has also developed algorithms for determining
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Donald's early research was in the field of robotic motion planning and distributed manipulation. Later he has made numerous contributions to MEMS and Micro-robotics, and designed MEMS micro-robots with dimensions of 60 μm by 250 μm by 10 μm.
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Potluri, S.; Yan, A.; Chou, J.; Donald, Bruce R.; Bailey-Kellogg, C. (2006). "Structure
Determination of Symmetric Homo-oligomers by a Complete Search of Symmetry Configuration Space Using NMR Restraints and van der Waals Packing".
892:"Accessible Animation and Customizable Graphics via Simplicial Configuration Modeling. T. Ngo, D. Cutrell, J. Dana, B. R. Donald, L. Loeb, and S. Zhu. Proc. ACM SIGGRAPH (New Orleans) July, 2000, pp. 403-410"
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704:"The Minimized Dead-End Elimination Criterion and Its Application to Protein Redesign in a Hybrid Scoring and Search Algorithm for Computing Partition Functions over Molecular Ensembles"
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Lilien, Ryan H.; Bailey-Kellogg, Chris; Anderson, Amy C.; Donald, Bruce R. (2004). "A subgroup algorithm to identify cross-rotation peaks consistent with non-crystallographic symmetry".
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Wang, Lincong; Mettu, Ramgopal R.; Donald, Bruce R. (2006). "A Polynomial-Time
Algorithm for De Novo Protein Backbone Structure Determination from NMR Data".
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Phylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthase
875:"System for Image Manipulation and Animation Using Embedded Constraint Graphics. J. T. Ngo and B. R. Donald. U.S. Patent #5,933,150, issued August 3, 1999"
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Recently, he has conducted research in the areas of
Structural Molecular Biology; chiefly, Protein Design and Protein Structure Determination from
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of
Computer Science, Chemistry, and Biochemistry, in the Trinity College of Arts and Sciences at Duke University and in the School of Medicine,
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308:(Artificial Intelligence Laboratory). He joined the Cornell University Department of Computer Science as an assistant professor in 1987.
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800:"High-Resolution Protein Structure Determination Starting with a Global Fold Calculated from Exact Solutions to the RDC Equations"
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Donald, Bruce R.; Levey, Christopher; Paprotny, Igor (2008). "Planar
Microassembly by Parallel Actuation of MEMS Microrobots".
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556:. Robert H. O'Neil, Ryan H. Lilien, Bruce R. Donald, Robert M. Stroud and Amy C. Anderson. J Biol Chem 2003. 278(52):52980-7.
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Donald has supervised many students and postdocs, many of whom are now professors in reputed universities such as
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Zeng, J.; Boyles, J.; Tripathy, C.; Wang, L.; Yan, A.; Zhou, P.; Donald, Bruce R. (2009).
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Frey, Kathleen M; Ivelin
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Donald is the author of over 100 publications. A representative selection includes:
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Cheng-; Chen, Yu; Georgiev, Ivelin; Anderson, Amy C.; Donald, Bruce R. (2009).
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Error
Detection and Recovery for Robot Motion Planning with Uncertainty
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in
Computer Science (1987) under the supervision of professor
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Georgiev, Ivelin; Lilien, Ryan H.; Donald, Bruce R. (2008).
242:, as well as in areas of Structural Molecular Biology &
747:"Computational structure-based redesign of enzyme activity"
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American Association for the Advancement of Science (AAAS)
226:. He has made numerous contributions to several fields in
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Bruce Donald in his laboratory at Duke University (2023).
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2009 fellows of the Association for Computing Machinery
378:(2001–2002) and received a National Science Foundation
323:'s research & development and technology incubator
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American computer scientist and computational biologist
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Laboratory for Computer Graphics and Spatial Analysis
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238:(MEMS), Geometric & physical algorithms and
751:Proceedings of the National Academy of Sciences
427:2009; 55(2):101-127). Donald is the author of
920:Bruce R. Donald, elected a Fellow of the AAAS
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431:, a textbook published by MIT Press (2011).
910:, Duke University Press Release; May, 2012.
471:, and researchers at organizations such as
382:(1989–1994). In 2015, Donald was elected a
429:Algorithms in Structural Molecular Biology
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961:Journal of Microelectromechanical Systems
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935:Error Detection and Recovery in Robotics
269:in Russian Language and Literature from
908:Duke Announces Distinguished Professors
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932:Donald, Bruce R. (September 4, 1989).
250:, Protein Structure Determination and
380:Presidential Young Investigator Award
75:Presidential Young Investigator Award
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315:until 1998. While on sabbatical at
453:University of Massachusetts Amherst
364:Association for Computing Machinery
708:Journal of Computational Chemistry
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449:University of Washington, Seattle
1147:MIT School of Engineering alumni
948:– via ACM Digital Library.
617:Journal of Computational Biology
410:data. He has developed numerous
1097:ACM Fellows Award: Bruce Donald
1066:"Donald Lab at Duke University"
495:Donald is the son of historian
392:computational molecular biology
349:Duke University Medical Center
273:in 1980. After working at the
236:Microelectromechanical Systems
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325:Interval Research Corporation
1132:American computer scientists
485:Sandia National Laboratories
425:Progress in NMR Spectroscopy
339:until 2006 when he moved to
333:Embedded Constraint Graphics
805:Journal of Biomolecular NMR
548:Kinodynamic Motion Planning
202:(born 1958) is an American
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1157:Cornell University faculty
1102:DBLP: Bruce Randall Donald
445:Carnegie-Mellon University
343:. Currently Donald is the
327:(1995-1997), where he and
319:(1994-1996), he worked at
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818:10.1007/s10858-009-9366-3
592:10.1107/S090744490400695X
499:and historian and editor
279:Graduate School of Design
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639:10.1089/cmb.2006.13.1267
292:, where he received his
1137:Duke University faculty
1092:Bruce Donald's Research
1087:Bruce Donald's homepage
1026:10.1073/pnas.1002162107
772:10.1073/pnas.0900266106
421:Cryptosporidium hominis
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374:. Previously, he was a
353:James B. Duke Professor
345:James B. Duke Professor
252:Computational Chemistry
212:James B. Duke Professor
208:computational biologist
116:Computational Chemistry
1162:Computational chemists
1142:Yale University alumni
240:computational geometry
1107:MEDLINE: Bruce Donald
858:"Bruce Donald's Vita"
469:University of Toronto
108:Computational Biology
79:Guggenheim Fellowship
533:Kinodynamic planning
497:David Herbert Donald
200:Bruce Randall Donald
1017:2010PNAS..10713707F
1011:(31): 13707–13712.
938:. Springer-Verlag.
763:2009PNAS..106.3764C
574:2004AcCrD..60.1057L
317:Stanford University
296:in EECS (1984) and
285:, he then attended
146:Stanford University
679:10.1002/prot.21091
562:Acta Crystallogr D
501:Aida DiPace Donald
465:Middlebury College
313:Cornell University
302:Tomás Lozano-Pérez
283:Harvard University
262:Donald received a
204:computer scientist
188:Tomás Lozano-Pérez
142:Cornell University
138:Harvard University
91:Fellow of the AAAS
87:Fellow of the IEEE
720:10.1002/jcc.20909
528:Protein Structure
457:Dartmouth College
376:Guggenheim Fellow
337:Dartmouth College
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154:Dartmouth College
150:Interval Research
98:Scientific career
83:Fellow of the ACM
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244:Biochemistry
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210:. He is the
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134:Institutions
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1122:1958 births
49:Nationality
1116:Categories
1050:30 January
844:References
412:algorithms
321:Paul Allen
306:MIT AI Lab
665:CiteSeerX
625:CiteSeerX
608:249011865
578:CiteSeerX
355:in 2012.
258:Biography
1045:20643959
981:12040410
836:19711185
791:19228942
738:18293294
687:16897780
657:Proteins
647:17037958
600:15159565
507:See also
435:Students
358:He is a
246:such as
232:robotics
230:such as
124:Robotics
52:American
1036:2922245
1013:Bibcode
827:2766249
782:2645347
759:Bibcode
729:3263346
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570:Bibcode
386:of the
370:of the
362:of the
329:Tom Ngo
304:in the
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104:Fields
71:Awards
999:(PDF)
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895:(PDF)
878:(PDF)
861:(PDF)
691:S2CID
604:S2CID
473:NIAID
298:Ph.D.
1052:2012
1041:PMID
1004:PNAS
940:ISBN
832:PMID
787:PMID
734:PMID
683:PMID
643:PMID
596:PMID
513:MEMS
477:NIST
467:and
414:for
398:Work
372:IEEE
294:S.M.
290:EECS
264:B.A.
218:and
206:and
61:Yale
44:1958
41:Born
1031:PMC
1021:doi
1009:107
969:doi
822:PMC
814:doi
777:PMC
767:doi
755:106
724:PMC
716:doi
675:doi
635:doi
588:doi
523:NMR
481:IBM
441:MIT
408:NMR
287:MIT
281:at
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214:of
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