31:
841:
1234:
169:) from C57BL/6N, etc. But even within these sublines, the potential for drift exists in colonies maintained by individual laboratories who do not have a systematic practice of reestablishing breeders from a centralized, vetted stock. The mice (as well as NOD and SJL) are known to have IgG2c allele.
110:
behavior, in which the dominant mouse in a cage selectively removes hair from its subordinate cage mates. Mice that have been barbered have large bald patches on their bodies, commonly around the head, snout, and shoulders, although barbering may appear anywhere on the body. Both hair and
197:
of all rodents shipped to research laboratories from
American suppliers. Its overwhelming popularity is due largely to inertia: it has been widely used and widely studied, and therefore it is used even more.
153:
The dark coat makes the mouse strain convenient for creating transgenic mice: it is crossed with a light-furred 129 mouse, and the desirable crosses can be easily identified by their mixed coat colors.
52:
It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of
165:). Responsible scientists, including those at accredited repositories, are careful to point out this fact and take pains to distinguish sublines such as C57BL/6J (the established subline at
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99:
C57BL/6 mice have a dark brown, nearly black coat. They are more sensitive to noise and odours and are more likely to bite than the more docile laboratory strains such as
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251:
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There now exist colonies of mice derived from the original C57BL/6 colony that have been bred in isolation from one another for many hundreds of generations. Owing to
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609:
1120:
344:
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118:
C57BL/6 has many unusual characteristics that make it useful for some work and inappropriate for others: It is unusually sensitive to pain and to cold, and
1095:
805:
425:
Mogil JS, Wilson SG, Bon K, et al. (March 1999). "Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception".
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Fox, James; Anderson, Lynn; Otto, Glen; Corning, Kathleen; Whary, Mark (2015). "Chapter 3 - Biology and
Diseases of Mice".
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959:
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In 1993 the first C57BL/6 gene targeted knockout mouse was published by a group at
Hoffmann-La Roche in Switzerland.
480:. Cambridge Handbooks in Behavioral Genetics. Cambridge, United Kingdom: Cambridge University Press. pp. 36–44.
355:
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these colonies differ widely from one another (and, it goes without saying, from the original mice isolated at the
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926:
875:
870:
810:
795:
785:
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Sarna, JR; Dyck, RH; Whishaw, IQ (February 2000). "The Dalila effect: C57BL6 mice barber whiskers by plucking".
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The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 months.
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294:"Abbie Lathrop, the "Mouse Woman of Granby": Rodent Fancier and Accidental Genetics Pioneer"
162:
46:
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75:. The substrain "6" was the most popular of the surviving substrains. Little's supervisor
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Köntgen, F.; Süss, G.; Stewart, C.; Steinmetz, M.; Bluethmann, H. (5 August 1993).
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135:
68:
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700:"LIFTOFF: FALCON 9 AND DRAGON BEGIN CRS-6 MISSION TO RESUPPLY THE SPACE STATION"
205:
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651:
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119:
41:, often referred to as "C57 black 6", "B6", "C57" or "black 6", is a common
534:
446:
403:
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146:
The C57BL/6 mouse was the second-ever mammalian species to have its entire
122:
medications are less effective in it. Unlike most mouse strains, it drinks
659:
310:
177:
By far the most popular laboratory rodent, the C57BL/6 mouse accounts for
1130:
112:
88:
53:
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had obtained the predecessor strain of C57BL/6, "mouse number 57", from
17:
840:
292:
Steensma, David P.; Kyle, Robert A.; Shampo, Marc A. (November 2010).
1002:
147:
107:
100:
478:
Behavioral
Genetics of the Mouse: Genetics of Behavioral Phenotypes
29:
715:
625:"Targeted disruption of the MHC class II Aa gene in C57BL/6 mice"
719:
252:"The Trouble With Black-6: A tiny alcoholic takes over the lab"
501:
Zhang, Zhiping; Goldschmidt, Tom; Salter, Hugh (2012-03-01).
503:"Possible allelic structure of IgG2a and IgG2c in mice"
67:
The inbred strain of C57BL mice was created in 1921 by
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voluntarily. It is more susceptible than average to
1222:
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990:
940:
889:
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204:In 2013 C57BL/6 mice were flown into space aboard
1023:Laboratory animal suppliers in the United Kingdom
87:for mammary tumor research in collaboration with
215:were sent to the International Space Station on
73:Bussey Institute for Research in Applied Biology
468:Willott, James F. (April 2013). "Audition". In
1121:Physicians Committee for Responsible Medicine
731:
8:
345:"Aurora's Guide to Mouse Colony Management"
738:
724:
716:
608:: CS1 maint: location missing publisher (
1086:Center for Alternatives to Animal Testing
319:
309:
1241:Animals (Scientific Procedures) Act 1986
932:Pain and suffering in laboratory animals
816:Pain and suffering in laboratory animals
211:In 2015 C57BL/6NTac females provided by
56:strains, easy breeding, and robustness.
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243:
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1235:Animal Experimentation Convention 1986
601:
354:. CMC Activity Center. Archived from
7:
1116:New England Anti-Vivisection Society
776:Animal testing on non-human primates
266:"The C57BL 6 (Black 6) Mouse Strain"
907:Animals (Scientific Procedures) Act
250:Engber, Daniel (17 November 2011).
1106:Foundation for Biomedical Research
562:10.1016/B978-0-12-409527-4.00003-1
106:Group-housed B6 male mice display
25:
1111:National Anti-Vivisection Society
27:Common strain of laboratory mouse
839:
766:Animal testing on invertebrates
476:; Pietropaolo, Susanna (eds.).
1056:Americans for Medical Progress
761:Alternatives to animal testing
1:
1161:Understanding Animal Research
960:Cambridge University primates
439:10.1016/s0304-3959(98)00197-3
396:10.1016/S0166-4328(99)00137-0
34:C57BL/6, female, 22 weeks old
821:Testing cosmetics on animals
519:10.1016/j.molimm.2011.11.006
1151:Stop Sequani Animal Testing
922:International primate trade
1302:
1253:Animal Welfare Act of 1966
1230:Animal testing regulations
1091:Cruelty Free International
1051:Anti-Vivisection Coalition
998:Charles River Laboratories
801:History of model organisms
791:Animal testing regulations
550:Laboratory Animal Medicine
383:Behavioural Brain Research
103:. They are good breeders.
927:Laboratory animal allergy
837:
811:Laboratory animal sources
796:History of animal testing
786:Animal testing on rodents
781:Animal testing on rabbits
1281:Laboratory mouse strains
1156:Research Defence Society
1018:Labcorp Drug Development
1013:Huntingdon Life Sciences
675:"Bion (12KSM) satellite"
632:International Immunology
1247:Animal Welfare Act 1999
1126:Primate Freedom Project
1071:Animal Free Research UK
771:Animal testing on frogs
298:Mayo Clinic Proceedings
95:Appearance and behavior
917:Great ape research ban
644:10.1093/intimm/5.8.957
352:Cell Migration Gateway
167:The Jackson Laboratory
35:
975:Silver Spring monkeys
343:Connor, A.B. (2006).
311:10.4065/mcp.2010.0647
33:
1259:Directive 2010/63/EU
1146:Speaking of Research
507:Molecular Immunology
361:on 23 September 2015
1237:(Council of Europe)
912:Biomedical Research
213:Taconic Biosciences
124:alcoholic beverages
965:Monkey Drug Trials
831:Toxicology testing
472:; Sluyter, Frans;
134:, and age-related
128:morphine addiction
36:
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596:978-0-12-409527-4
571:978-0-12-416613-4
487:978-1-107-03481-5
474:Gerlai, Robert T.
83:who was breeding
77:William E. Castle
16:(Redirected from
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1286:Space-flown life
981:Unnecessary Fuss
955:Brown Dog affair
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115:may be removed.
47:laboratory mouse
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673:Zak, Anatoly.
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638:(8): 957–964.
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556:. p. 70.
552:(3 ed.).
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513:(3): 169–171.
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470:Crusio, Wim E.
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433:(1–2): 67–82.
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85:inbred strains
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754:Main articles
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91:at the time.
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81:Abbie Lathrop
78:
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60:
57:
55:
50:
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44:
43:inbred strain
40:
32:
19:
1204:Jerry Vlasak
1189:Gill Langley
979:
703:. Retrieved
694:
682:. Retrieved
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390:(1): 39–45.
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363:. Retrieved
356:the original
351:
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275:. Retrieved
269:
260:
254:. Slate.com.
217:SpaceX CRS-6
210:
203:
200:
176:
156:
152:
145:
136:hearing loss
117:
105:
98:
69:C. C. Little
66:
58:
51:
38:
37:
1223:Legislation
1170:Writers and
943:experiments
365:19 December
304:(11): e83.
271:Lifespan.io
206:Bion-M No.1
150:published.
1275:Categories
1184:Carl Cohen
1081:Boyd Group
1042:Groups and
849:Testing on
223:References
173:Popularity
1214:Tipu Aziz
1172:activists
1044:campaigns
1028:Nafovanny
991:Companies
652:0953-8178
604:cite book
580:913513718
554:Amsterdam
527:0161-5890
120:analgesic
108:barbering
1131:Pro-Test
1033:Shamrock
950:Britches
866:Primates
826:Three Rs
705:14 April
684:19 April
588:88753861
535:22177661
455:17604906
447:10204719
412:18334770
404:10680755
330:21061734
142:Genetics
113:whiskers
89:Leo Loeb
54:congenic
18:C57BL/6J
876:Rodents
871:Rabbits
660:8398989
321:2966381
277:27 July
192:⁄
182:⁄
71:at the
39:C57BL/6
1008:Harlan
1003:Envigo
890:Issues
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650:
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586:
578:
568:
533:
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484:
453:
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410:
402:
328:
318:
148:genome
101:BALB/c
63:Origin
1141:SPEAK
1066:AALAS
856:Frogs
806:IACUC
628:(PDF)
584:S2CID
451:S2CID
408:S2CID
359:(PDF)
348:(PDF)
1261:(EU)
1255:(US)
1249:(NZ)
1243:(UK)
1136:SHAC
1096:PETA
1061:AAAS
707:2015
686:2013
656:PMID
648:ISSN
610:link
592:ISBN
576:OCLC
566:ISBN
531:PMID
523:ISSN
482:ISBN
443:PMID
427:Pain
400:PMID
367:2013
326:PMID
279:2023
1101:ALF
1076:ALF
640:doi
558:doi
515:doi
435:doi
392:doi
388:108
316:PMC
306:doi
187:to
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
