329:
306:
203:
228:
2272:
2302:
2257:
2287:
335:
234:
40:
3224:
3305:
3244:
1545:
Luo C, Thielens NM, Gagnon J, Gal P, Sarvari M, Tseng Y, Tosi M, Zavodszky P, Arlaud GJ, Schumaker VN (May 1992). "Recombinant human complement subcomponent C1s lacking beta-hydroxyasparagine, sialic acid, and one of its two carbohydrate chains still reassembles with C1q and C1r to form a functional
66:
2089:
Lacroix M, Rossi V, Gaboriaud C, Chevallier S, Jaquinod M, Thielens NM, Gagnon J, Arlaud GJ (May 1997). "Structure and assembly of the catalytic region of human complement protease C1r: a three-dimensional model based on chemical cross-linking and homology modeling".
1685:
Nguyen VC, Tosi M, Gross MS, Cohen-Haguenauer O, Jegou-Foubert C, de Tand MF, Meo T, Frézal J (April 1988). "Assignment of the complement serine protease genes C1r and C1s to chromosome 12 region 12p13".
2148:
Bersch B, Hernandez JF, Marion D, Arlaud GJ (February 1998). "Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family".
1604:
Lyons LA, Kamboh MI, Ferrell RE (1989). "Genetic studies of low-abundance human plasma proteins. XI. Linkage analysis and population genetics of the C1S subcomponent of the first complement component".
1487:
Lee SL, Wallace SL, Barone R, Blum L, Chase PH (1979). "Familial deficiency of two subunits of the first component of complement. C1r and C1s associated with a lupus erythematosus-like disease".
1516:
Ward SL, Ingham KC (January 1992). "A calcium-binding monoclonal antibody that recognizes a non-calcium-binding epitope in the short consensus repeat units (SCRs) of complement C1r".
3169:
2119:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
3029:
2271:
1402:"The N-terminal CUB-epidermal growth factor module pair of human complement protease C1r binds Ca2+ with high affinity and mediates Ca2+-dependent interaction with C1s"
342:
241:
2301:
2769:
2342:
2256:
804:
2005:"Identification of a cryptic protein kinase CK2 phosphorylation site in human complement protease Clr, and its use to probe intramolecular interaction"
164:
2286:
785:
3380:
1910:
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
1443:"Interaction of C1q and mannan-binding lectin (MBL) with C1r, C1s, MBL-associated serine proteases 1 and 2, and the MBL-associated protein MAp19"
3346:
3289:
1257:
3365:
2236:
1239:
1575:
Busby TF, Ingham KC (May 1990). "NH2-terminal calcium-binding domain of human complement C1s- mediates the interaction of C1r- with C1q".
2762:
328:
2556:
1023:
2186:
1292:
1016:
305:
1723:
Leytus SP, Kurachi K, Sakariassen KS, Davie EW (August 1986). "Nucleotide sequence of the cDNA coding for human complement C1r".
1316:
Leytus SP, Kurachi K, Sakariassen KS, Davie EW (August 1986). "Nucleotide sequence of the cDNA coding for human complement C1r".
2335:
1881:
Arlaud GJ, Gagnon J (April 1983). "Complete amino acid sequence of the catalytic chain of human complement subcomponent C1-r".
1226:
1205:
2755:
2375:
1970:"Expression of the complement classical pathway by human glioma in culture. A model for complement expression by nerve cells"
1840:"Fluid-phase interaction of C1 inhibitor (C1 Inh) and the subcomponents C1r and C1s of the first component of complement, C1"
227:
202:
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63:
1201:
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2192:
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2365:
1386:
144:
1150:
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2789:
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Thiel S, Petersen SV, Vorup-Jensen T, Matsushita M, Fujita T, Stover CM, Schwaeble WJ, Jensenius JC (July 2000).
334:
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2658:
2459:
216:
3124:
2673:
2668:
2222:
2016:
1754:"Cloning and sequencing of full-length cDNA encoding the precursor of human complement component C1r"
1647:
1108:
1939:
Nöthen MM, Dewald G (January 1994). "A common amino acid polymorphism in complement component C1R".
131:
3024:
3014:
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2826:
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999:
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2054:
Bradley K, North J, Saunders D, Schwaeble W, Jeziorska M, Woolley DE, Whaley K (August 1996).
2034:
1991:
1956:
1927:
1898:
1869:
1826:
1797:"Complete amino acid sequence of the A chain of human complement-classical-pathway enzyme C1r"
1783:
1740:
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1592:
1563:
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1504:
1464:
1423:
1368:
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124:
56:
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3259:
1400:
Thielens NM, Enrie K, Lacroix M, Jaquinod M, Hernandez JF, Esser AF, Arlaud GJ (April 1999).
2798:
2725:
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2024:
1981:
1948:
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1454:
1413:
1360:
1325:
1280:
421:
352:
296:
251:
1351:
Müller-Eberhard HJ (1988). "Molecular organization and function of the complement system".
3039:
3034:
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2782:
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2450:
2204:
396:
172:
2020:
1651:
1364:
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2132:
2003:
Pelloux S, Thielens NM, Hudry-Clergeon G, Pétillot Y, Filhol O, Arlaud GJ (May 1996).
1986:
1969:
1636:"Identification of erythro-beta-hydroxyasparagine in the EGF-like domain of human C1r"
1284:
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2004:
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1529:
599:
2046:
1968:
Gasque P, Ischenko A, Legoedec J, Mauger C, Schouft MT, Fontaine M (November 1993).
1715:
1677:
1275:
Sim RB (1981). "The human complement system serine proteases and their proenzymes".
156:
39:
3080:
2974:
2816:
2736:
2731:
2719:
2701:
2696:
2606:
1634:
Arlaud GJ, Van
Dorsselaer A, Bell A, Mancini M, Aude C, Gagnon J (September 1987).
414:
193:
2280:: THE CRYSTAL STRUCTURE OF THE ZYMOGEN CATALYTIC DOMAIN OF COMPLEMENT PROTEASE C1R
180:
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1262:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1244:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1177:
1138:
3223:
2310:: Monomeric structure of the active catalytic domain of complement protease C1r
1459:
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2401:
1130:
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210:
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1952:
1418:
1401:
1202:
ENSG00000288512 GRCh38: Ensembl release 89: ENSG00000159403, ENSG00000288512
749:
557:
435:
380:
367:
279:
266:
168:
1500:
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1995:
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1931:
1902:
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1744:
1707:
1669:
1626:
1596:
1567:
1537:
1372:
1337:
1302:
1133:, which is the first component of the serum complement system. C1r is an
1063:
3075:
3070:
3019:
2869:
2854:
2821:
2640:
2474:
1508:
1082:
1047:
898:
879:
1894:
1838:
Chesne S, Villiers CL, Arlaud GJ, Lacroix MB, Colomb MG (January 1982).
1736:
1588:
1559:
1329:
1058:
3312:
3129:
3119:
3065:
2979:
2811:
1699:
1100:
865:
816:
3304:
2162:
2103:
2056:"Synthesis of classical pathway complement components by chondrocytes"
1855:
1812:
1769:
1618:
101:
97:
93:
89:
85:
3156:
3098:
1134:
1031:
771:
3243:
2320:
2265:: STRUCTURE OF THE EGF-LIKE MODULE OF HUMAN C1R, NMR, 19 STRUCTURES
17:
3165:
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734:
730:
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2909:
2899:
2894:
2686:
2615:
2509:
1157:
1115:
148:
2751:
2324:
2295:: Monomeric structure of the zymogen of complement protease C1r
2218:
2505:
2433:
2428:
2214:
1173:
1126:
1122:
1279:. Methods in Enzymology. Vol. 80 Pt C. pp. 26–42.
1387:"Entrez Gene: C1R complement component 1, r subcomponent"
404:
3320:
3263:
3212:
1153:
Periodontal type is associated with mutations in the
569:
3112:
3089:
3055:
3005:
2842:
2797:
2712:
2649:
2596:
2549:
2488:
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2384:
2358:
992:
967:
941:
916:
524:
dentate gyrus of hippocampal formation granule cell
1218:
1216:
1214:
1197:
1195:
1193:
351:
250:
1795:Arlaud GJ, Willis AC, Gagnon J (February 1987).
1223:GRCm38: Ensembl release 89: ENSMUSG00000098470
3340:
3283:
2763:
2336:
2230:
8:
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3333:
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2770:
2756:
2748:
2388:
2343:
2329:
2321:
2237:
2223:
2215:
1137:that activates C1s to its active form, by
745:
595:
392:
291:
188:
74:
2207:at the U.S. National Library of Medicine
2071:
2028:
1985:
1863:
1820:
1777:
1659:
1458:
1417:
695:complement activation, classical pathway
3219:
2252:
1189:
2783:serine proteases/serine endopeptidases
29:
356:
317:
312:
255:
214:
209:
7:
3301:
3299:
3240:
3238:
1180:C1s to form the active form of C1s.
1974:The Journal of Biological Chemistry
1752:Journet A, Tosi M (December 1986).
1406:The Journal of Biological Chemistry
1365:10.1146/annurev.bi.57.070188.001541
1111:. In humans, C1r is encoded by the
715:regulation of complement activation
3319:. You can help Knowledge (XXG) by
3262:. You can help Knowledge (XXG) by
989:
964:
938:
913:
889:
870:
844:
821:
795:
776:
623:serine-type endopeptidase activity
574:
492:
430:
409:
25:
3303:
3242:
3222:
2300:
2285:
2270:
2255:
340:
333:
327:
304:
239:
232:
226:
201:
38:
3381:Human chromosome 12 gene stubs
618:serine-type peptidase activity
558:More reference expression data
1:
2995:Urinary plasminogen activator
2133:10.1016/S0378-1119(97)00411-3
1987:10.1016/S0021-9258(19)74572-4
1353:Annual Review of Biochemistry
1285:10.1016/s0076-6879(81)80006-7
325:
224:
27:Protein-coding gene in humans
3366:Genes on human chromosome 12
2990:Tissue plasminogen activator
2030:10.1016/0014-5793(96)00403-6
1924:10.1016/0378-1119(94)90802-8
1661:10.1016/0014-5793(87)80205-3
1530:10.1016/0161-5890(92)90160-Y
1607:Complement and Inflammation
1277:Proteolytic Enzymes, Part C
1076:Complement C1r subcomponent
3402:
3298:
3237:
2197:gene details page in the
1460:10.4049/jimmunol.165.2.878
3081:Proteinase 3/Myeloblastin
2612:Decay-accelerating factor
2250:
1258:"Mouse PubMed Reference:"
1240:"Human PubMed Reference:"
1062:
1057:
1053:
1046:
1030:
1024:Chr 6: 124.55 – 124.56 Mb
1011:
996:
971:
960:
945:
920:
909:
896:
892:
877:
873:
864:
851:
847:
828:
824:
815:
802:
798:
783:
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755:
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728:
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142:
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82:
77:
60:
55:
50:
46:
37:
32:
2209:Medical Subject Headings
1941:Human Molecular Genetics
1489:Arthritis and Rheumatism
1087:activated complement C1r
135:, complement C1r, EDSPD1
1844:The Biochemical Journal
1801:The Biochemical Journal
1758:The Biochemical Journal
1419:10.1074/jbc.274.14.9149
3315:-related article is a
3135:Proprotein convertases
1501:10.1002/art.1780210813
1168:C1r has been shown to
1151:Ehlers–Danlos syndrome
1091:C overbar 1r esterase
1017:Chr 12: 7.08 – 7.09 Mb
705:innate immune response
536:skeletal muscle tissue
2985:Plasminogen activator
1953:10.1093/hmg/3.1.217-a
1447:Journal of Immunology
1145:Clinical significance
710:complement activation
700:immune system process
664:extracellular exosome
458:right coronary artery
217:Chromosome 12 (human)
3125:Prolyl endopeptidase
2651:Complement receptors
2191:genome location and
1518:Molecular Immunology
1109:innate immune system
654:extracellular region
508:white adipose tissue
474:left coronary artery
319:Chromosome 6 (mouse)
78:List of PDB id codes
51:Available structures
2199:UCSC Genome Browser
2021:1996FEBSL.386...15P
1895:10.1021/bi00277a003
1737:10.1021/bi00365a020
1652:1987FEBSL.222..129A
1589:10.1021/bi00471a016
1560:10.1021/bi00132a015
1330:10.1021/bi00365a020
669:extracellular space
659:blood microparticle
638:calcium ion binding
544:islet of Langerhans
482:canal of the cervix
446:right lobe of liver
3250:This article on a
2480:Factor P/Properdin
2385:Activators/enzymes
1700:10.1007/BF00291737
854:ENSMUSG00000098470
720:zymogen activation
678:Biological process
647:Cellular component
633:hydrolase activity
613:peptidase activity
606:Molecular function
3371:Complement system
3328:
3327:
3271:
3270:
3210:
3209:
3007:Complement system
2799:Digestive enzymes
2745:
2744:
2592:
2591:
2352:Complement system
2318:
2317:
2163:10.1021/bi971851v
2104:10.1021/bi962719i
1856:10.1042/bj2010061
1813:10.1042/bj2410711
1770:10.1042/bj2400783
1619:10.1159/000463078
1105:complement system
1073:
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1068:
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1006:
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955:
935:
934:
905:
904:
886:
885:
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859:
841:
840:
811:
810:
792:
791:
740:
739:
590:
589:
586:
585:
564:
563:
551:
550:
489:
488:
470:left uterine tube
387:
386:
286:
285:
113:
112:
109:
108:
61:Ortholog search:
16:(Redirected from
3393:
3349:
3342:
3335:
3307:
3300:
3292:
3285:
3278:
3246:
3239:
3227:
3226:
3218:
2772:
2765:
2758:
2749:
2726:immune adherence
2389:
2345:
2338:
2331:
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2304:
2289:
2274:
2259:
2239:
2232:
2225:
2216:
2174:
2144:
2115:
2085:
2075:
2050:
2032:
1999:
1989:
1980:(33): 25068–74.
1964:
1935:
1906:
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1867:
1834:
1824:
1791:
1781:
1748:
1719:
1681:
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1307:
1306:
1272:
1266:
1265:
1254:
1248:
1247:
1236:
1230:
1220:
1209:
1199:
1103:involved in the
1055:
1054:
1026:
1019:
1002:
990:
981:
965:
961:RefSeq (protein)
951:
939:
930:
914:
890:
871:
845:
822:
796:
777:
746:
596:
575:
560:
500:
498:Top expressed in
493:
438:
436:Top expressed in
431:
410:
393:
383:
370:
359:
344:
337:
331:
320:
308:
292:
282:
269:
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243:
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127:
104:
75:
69:
48:
47:
42:
30:
21:
3401:
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3390:
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3353:
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3296:
3235:
3233:
3221:
3213:
3211:
3206:
3108:
3085:
3051:
3001:
2838:
2807:Enteropeptidase
2793:
2776:
2746:
2741:
2708:
2645:
2588:
2545:
2484:
2380:
2354:
2349:
2319:
2314:
2311:
2305:
2296:
2290:
2281:
2275:
2266:
2260:
2246:
2243:
2182:
2177:
2147:
2127:(1–2): 149–56.
2118:
2098:(21): 6270–82.
2088:
2053:
2002:
1967:
1938:
1909:
1880:
1837:
1794:
1751:
1731:(17): 4855–63.
1722:
1684:
1633:
1603:
1574:
1554:(17): 4254–62.
1544:
1515:
1486:
1482:
1480:Further reading
1477:
1476:
1440:
1439:
1435:
1412:(14): 9149–59.
1399:
1398:
1394:
1385:
1384:
1380:
1350:
1349:
1345:
1324:(17): 4855–63.
1315:
1314:
1310:
1295:
1274:
1273:
1269:
1256:
1255:
1251:
1238:
1237:
1233:
1221:
1212:
1200:
1191:
1186:
1166:
1147:
1121:C1r along with
1064:View/Edit Mouse
1059:View/Edit Human
1022:
1015:
1012:Location (UCSC)
998:
977:
973:
947:
926:
922:
835:ENSG00000288512
833:
831:ENSG00000159403
724:
685:immune response
673:
642:
628:protein binding
556:
547:
542:
538:
534:
530:
526:
522:
520:urinary bladder
518:
516:muscle of thigh
514:
510:
496:
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478:urinary bladder
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295:Gene location (
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245:
244:
237:
215:
192:Gene location (
181:C1R - orthologs
143:
130:
123:
84:
62:
28:
23:
22:
15:
12:
11:
5:
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3142:
3132:
3127:
3122:
3116:
3114:
3110:
3109:
3107:
3106:
3101:
3095:
3093:
3087:
3086:
3084:
3083:
3078:
3073:
3068:
3062:
3060:
3053:
3052:
3050:
3049:
3044:
3043:
3042:
3037:
3027:
3022:
3017:
3011:
3009:
3003:
3002:
3000:
2999:
2998:
2997:
2992:
2982:
2970:
2969:
2968:
2967:
2962:
2957:
2952:
2947:
2942:
2937:
2932:
2927:
2922:
2917:
2912:
2907:
2902:
2897:
2892:
2882:
2877:
2872:
2867:
2862:
2857:
2848:
2846:
2840:
2839:
2837:
2836:
2835:
2834:
2829:
2819:
2814:
2809:
2803:
2801:
2795:
2794:
2779:Endopeptidases
2777:
2775:
2774:
2767:
2760:
2752:
2743:
2742:
2740:
2739:
2734:
2728:
2723:
2716:
2714:
2710:
2709:
2707:
2706:
2705:
2704:
2699:
2689:
2676:
2671:
2666:
2661:
2655:
2653:
2647:
2646:
2644:
2643:
2634:
2633:
2624:
2623:
2618:
2609:
2600:
2598:
2594:
2593:
2590:
2589:
2587:
2586:
2585:
2584:
2579:
2574:
2569:
2564:
2553:
2551:
2547:
2546:
2544:
2543:
2538:
2532:
2531:
2530:
2529:
2524:
2514:
2513:
2512:
2503:
2492:
2490:
2486:
2485:
2483:
2482:
2477:
2472:
2463:
2462:
2457:
2444:
2443:
2438:
2437:
2436:
2431:
2421:
2420:
2419:
2414:
2409:
2395:
2393:
2386:
2382:
2381:
2379:
2378:
2373:
2368:
2362:
2360:
2356:
2355:
2350:
2348:
2347:
2340:
2333:
2325:
2316:
2315:
2313:
2312:
2306:
2299:
2297:
2291:
2284:
2282:
2276:
2269:
2267:
2261:
2254:
2251:
2248:
2247:
2244:
2242:
2241:
2234:
2227:
2219:
2213:
2212:
2205:Complement+C1r
2202:
2181:
2180:External links
2178:
2176:
2175:
2157:(5): 1204–14.
2145:
2116:
2086:
2051:
2000:
1965:
1936:
1918:(1–2): 171–4.
1907:
1889:(8): 1758–64.
1878:
1835:
1792:
1749:
1720:
1688:Human Genetics
1682:
1631:
1601:
1583:(19): 4613–8.
1572:
1542:
1513:
1483:
1481:
1478:
1475:
1474:
1433:
1392:
1378:
1343:
1308:
1293:
1267:
1249:
1231:
1210:
1188:
1187:
1185:
1182:
1165:
1162:
1161:
1160:
1146:
1143:
1071:
1070:
1067:
1066:
1061:
1051:
1050:
1044:
1043:
1040:
1039:
1037:
1035:
1028:
1027:
1020:
1013:
1009:
1008:
1005:
1004:
994:
993:
987:
984:
983:
969:
968:
962:
958:
957:
954:
953:
943:
942:
936:
933:
932:
918:
917:
911:
907:
906:
903:
902:
894:
893:
887:
884:
883:
875:
874:
868:
862:
861:
858:
857:
849:
848:
842:
839:
838:
826:
825:
819:
813:
812:
809:
808:
800:
799:
793:
790:
789:
781:
780:
774:
768:
767:
762:
757:
753:
752:
742:
741:
738:
737:
726:
725:
723:
722:
717:
712:
707:
702:
697:
692:
687:
681:
679:
675:
674:
672:
671:
666:
661:
656:
650:
648:
644:
643:
641:
640:
635:
630:
625:
620:
615:
609:
607:
603:
602:
592:
591:
588:
587:
584:
583:
580:
579:
572:
566:
565:
562:
561:
553:
552:
549:
548:
546:
545:
541:
537:
533:
529:
525:
521:
517:
513:
509:
505:
502:
501:
490:
487:
486:
484:
483:
479:
475:
471:
467:
463:
462:gastric mucosa
459:
455:
451:
447:
443:
440:
439:
427:
426:
418:
407:
401:
400:
397:RNA expression
389:
388:
385:
384:
376:
372:
371:
363:
360:
355:
349:
348:
339:
332:
326:
322:
321:
316:
310:
309:
301:
300:
288:
287:
284:
283:
275:
271:
270:
262:
259:
254:
248:
247:
238:
231:
225:
221:
220:
213:
207:
206:
198:
197:
185:
184:
141:
137:
136:
128:
120:
119:
115:
114:
111:
110:
107:
106:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3398:
3387:
3386:Protein stubs
3384:
3382:
3379:
3377:
3374:
3372:
3369:
3367:
3364:
3363:
3361:
3350:
3345:
3343:
3338:
3336:
3331:
3330:
3324:
3322:
3318:
3314:
3309:
3306:
3302:
3293:
3288:
3286:
3281:
3279:
3274:
3273:
3267:
3265:
3261:
3257:
3256:chromosome 12
3253:
3248:
3245:
3241:
3236:
3230:
3225:
3220:
3216:
3201:
3198:
3196:
3193:
3192:
3191:
3188:
3186:
3185:Streptokinase
3183:
3181:
3177:
3174:
3171:
3167:
3163:
3160:
3158:
3155:
3153:
3150:
3146:
3143:
3141:
3138:
3137:
3136:
3133:
3131:
3128:
3126:
3123:
3121:
3118:
3117:
3115:
3111:
3105:
3102:
3100:
3097:
3096:
3094:
3092:
3088:
3082:
3079:
3077:
3074:
3072:
3069:
3067:
3064:
3063:
3061:
3059:
3058:immune system
3054:
3048:
3047:C3-convertase
3045:
3041:
3038:
3036:
3033:
3032:
3031:
3028:
3026:
3023:
3021:
3018:
3016:
3013:
3012:
3010:
3008:
3004:
2996:
2993:
2991:
2988:
2987:
2986:
2983:
2981:
2978:
2976:
2972:
2971:
2966:
2963:
2961:
2958:
2956:
2953:
2951:
2948:
2946:
2943:
2941:
2938:
2936:
2933:
2931:
2928:
2926:
2923:
2921:
2918:
2916:
2913:
2911:
2908:
2906:
2903:
2901:
2898:
2896:
2893:
2891:
2888:
2887:
2886:
2883:
2881:
2878:
2876:
2873:
2871:
2868:
2866:
2863:
2861:
2858:
2856:
2853:
2850:
2849:
2847:
2845:
2841:
2833:
2830:
2828:
2825:
2824:
2823:
2820:
2818:
2815:
2813:
2810:
2808:
2805:
2804:
2802:
2800:
2796:
2791:
2788:
2784:
2780:
2773:
2768:
2766:
2761:
2759:
2754:
2753:
2750:
2738:
2735:
2733:
2729:
2727:
2724:
2721:
2718:
2717:
2715:
2711:
2703:
2700:
2698:
2695:
2694:
2693:
2692:Anaphylatoxin
2690:
2688:
2684:
2680:
2677:
2675:
2672:
2670:
2667:
2665:
2662:
2660:
2657:
2656:
2654:
2652:
2648:
2642:
2639:
2636:
2635:
2632:
2629:
2626:
2625:
2622:
2619:
2617:
2613:
2610:
2608:
2605:
2602:
2601:
2599:
2595:
2583:
2580:
2578:
2575:
2573:
2570:
2568:
2565:
2563:
2560:
2559:
2558:
2555:
2554:
2552:
2548:
2542:
2541:C5-convertase
2539:
2537:
2536:C3-convertase
2534:
2533:
2528:
2525:
2523:
2520:
2519:
2518:
2515:
2511:
2507:
2504:
2502:
2499:
2498:
2497:
2494:
2493:
2491:
2487:
2481:
2478:
2476:
2473:
2471:
2468:
2465:
2464:
2461:
2458:
2456:
2452:
2449:
2446:
2445:
2442:
2439:
2435:
2432:
2430:
2427:
2426:
2425:
2422:
2418:
2415:
2413:
2410:
2408:
2405:
2404:
2403:
2400:
2397:
2396:
2394:
2390:
2387:
2383:
2377:
2374:
2372:
2369:
2367:
2364:
2363:
2361:
2357:
2353:
2346:
2341:
2339:
2334:
2332:
2327:
2326:
2323:
2309:
2303:
2298:
2294:
2288:
2283:
2279:
2273:
2268:
2264:
2258:
2253:
2249:
2240:
2235:
2233:
2228:
2226:
2221:
2220:
2217:
2210:
2206:
2203:
2200:
2196:
2195:
2190:
2189:
2184:
2183:
2179:
2172:
2168:
2164:
2160:
2156:
2152:
2146:
2142:
2138:
2134:
2130:
2126:
2122:
2117:
2113:
2109:
2105:
2101:
2097:
2093:
2087:
2083:
2079:
2074:
2069:
2066:(4): 648–56.
2065:
2061:
2057:
2052:
2048:
2044:
2040:
2036:
2031:
2026:
2022:
2018:
2014:
2010:
2006:
2001:
1997:
1993:
1988:
1983:
1979:
1975:
1971:
1966:
1962:
1958:
1954:
1950:
1946:
1942:
1937:
1933:
1929:
1925:
1921:
1917:
1913:
1908:
1904:
1900:
1896:
1892:
1888:
1884:
1879:
1875:
1871:
1866:
1861:
1857:
1853:
1849:
1845:
1841:
1836:
1832:
1828:
1823:
1818:
1814:
1810:
1807:(3): 711–20.
1806:
1802:
1798:
1793:
1789:
1785:
1780:
1775:
1771:
1767:
1763:
1759:
1755:
1750:
1746:
1742:
1738:
1734:
1730:
1726:
1721:
1717:
1713:
1709:
1705:
1701:
1697:
1693:
1689:
1683:
1679:
1675:
1671:
1667:
1662:
1657:
1653:
1649:
1646:(1): 129–34.
1645:
1641:
1637:
1632:
1628:
1624:
1620:
1616:
1612:
1608:
1602:
1598:
1594:
1590:
1586:
1582:
1578:
1573:
1569:
1565:
1561:
1557:
1553:
1549:
1546:C1 complex".
1543:
1539:
1535:
1531:
1527:
1523:
1519:
1514:
1510:
1506:
1502:
1498:
1495:(8): 958–67.
1494:
1490:
1485:
1484:
1479:
1470:
1466:
1461:
1456:
1453:(2): 878–87.
1452:
1448:
1444:
1437:
1434:
1429:
1425:
1420:
1415:
1411:
1407:
1403:
1396:
1393:
1388:
1382:
1379:
1374:
1370:
1366:
1362:
1358:
1354:
1347:
1344:
1339:
1335:
1331:
1327:
1323:
1319:
1312:
1309:
1304:
1300:
1296:
1294:9780121819804
1290:
1286:
1282:
1278:
1271:
1268:
1263:
1259:
1253:
1250:
1245:
1241:
1235:
1232:
1228:
1224:
1219:
1217:
1215:
1211:
1207:
1203:
1198:
1196:
1194:
1190:
1183:
1181:
1179:
1175:
1171:
1163:
1159:
1156:
1152:
1149:
1148:
1144:
1142:
1140:
1136:
1132:
1128:
1124:
1119:
1117:
1114:
1110:
1106:
1102:
1098:
1097:
1092:
1088:
1084:
1081:
1077:
1065:
1060:
1056:
1052:
1049:
1045:
1038:
1036:
1033:
1029:
1025:
1021:
1018:
1014:
1010:
1003:
1001:
995:
991:
988:
982:
980:
976:
970:
966:
963:
959:
952:
950:
944:
940:
937:
931:
929:
925:
919:
915:
912:
910:RefSeq (mRNA)
908:
901:
900:
895:
891:
888:
882:
881:
876:
872:
869:
867:
863:
856:
855:
850:
846:
843:
837:
836:
832:
827:
823:
820:
818:
814:
807:
806:
801:
797:
794:
788:
787:
782:
778:
775:
773:
769:
766:
763:
761:
758:
754:
751:
747:
743:
736:
732:
727:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
682:
680:
677:
676:
670:
667:
665:
662:
660:
657:
655:
652:
651:
649:
646:
645:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
610:
608:
605:
604:
601:
600:Gene ontology
597:
593:
581:
576:
573:
571:
567:
559:
554:
543:
539:
535:
531:
527:
523:
519:
515:
512:adrenal gland
511:
507:
506:
503:
499:
494:
491:
481:
477:
473:
469:
465:
461:
457:
453:
449:
445:
444:
441:
437:
432:
429:
428:
425:
423:
419:
417:
416:
412:
411:
408:
406:
402:
398:
394:
390:
382:
377:
373:
369:
364:
354:
350:
343:
336:
330:
323:
315:
311:
307:
302:
298:
293:
289:
281:
276:
272:
268:
263:
253:
249:
242:
235:
229:
222:
218:
212:
208:
204:
199:
195:
190:
186:
182:
178:
174:
170:
166:
162:
158:
154:
150:
146:
138:
133:
126:
121:
116:
105:
103:
99:
95:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
3321:expanding it
3310:
3264:expanding it
3249:
3234:
2975:fibrinolysis
2973:
2851:
2817:Chymotrypsin
2737:Opsonization
2732:inflammation
2720:Cytotoxicity
2637:
2627:
2607:C1-inhibitor
2603:
2466:
2447:
2411:
2398:
2307:
2292:
2277:
2262:
2193:
2187:
2154:
2151:Biochemistry
2150:
2124:
2120:
2095:
2092:Biochemistry
2091:
2063:
2059:
2015:(1): 15–20.
2012:
2009:FEBS Letters
2008:
1977:
1973:
1944:
1940:
1915:
1911:
1886:
1883:Biochemistry
1882:
1850:(1): 61–70.
1847:
1843:
1804:
1800:
1764:(3): 783–7.
1761:
1757:
1728:
1725:Biochemistry
1724:
1694:(4): 363–8.
1691:
1687:
1643:
1640:FEBS Letters
1639:
1610:
1606:
1580:
1577:Biochemistry
1576:
1551:
1548:Biochemistry
1547:
1524:(1): 83–93.
1521:
1517:
1492:
1488:
1450:
1446:
1436:
1409:
1405:
1395:
1381:
1356:
1352:
1346:
1321:
1318:Biochemistry
1317:
1311:
1276:
1270:
1261:
1252:
1243:
1234:
1167:
1154:
1120:
1112:
1095:
1094:
1090:
1086:
1075:
1074:
1000:NP_001106827
997:
979:NP_001341275
972:
949:NM_001113356
946:
928:NM_001354346
921:
897:
878:
852:
829:
803:
784:
764:
759:
420:
413:
379:124,558,130
366:124,547,253
140:External IDs
83:
2880:Factor XIIa
2860:Factor VIIa
2844:Coagulation
2245:PDB gallery
1613:(2): 81–7.
1139:proteolytic
690:proteolysis
454:gallbladder
450:right ovary
358:6 F2|6
118:Identifiers
3360:Categories
3162:Subtilisin
3104:Batroxobin
2885:Kallikrein
2875:Factor XIa
2865:Factor IXa
2832:Pancreatic
2827:Neutrophil
2597:Inhibitors
2060:Immunology
1947:(1): 217.
1359:: 321–47.
1229:, May 2017
1208:, May 2017
1184:References
1141:cleavage.
1131:C1 complex
466:left ovary
424:(ortholog)
278:7,092,540
265:7,080,214
161:HomoloGene
3376:EC 3.4.21
3254:on human
3190:Cathepsin
3176:Sedolisin
3152:Prostasin
2870:Factor Xa
2730:Inducing
1129:form the
1083:3.4.21.41
975:NP_001724
924:NM_001733
750:Orthologs
169:GeneCards
3091:Venombin
3076:Tryptase
3071:Granzyme
3025:Factor I
3020:Factor D
3015:Factor B
2855:Thrombin
2852:factors:
2822:Elastase
2722:(by MAC)
2713:Function
2641:Factor H
2621:Factor I
2475:Factor D
2470:Factor B
2359:Pathways
2047:28372780
1716:30582112
1678:36194093
1469:10878362
1428:10092586
1225:–
1204:–
1170:interact
1164:Function
1048:Wikidata
729:Sources:
257:12p13.31
3313:protein
3229:Biology
3130:Pronase
3120:Acrosin
3066:Chymase
2980:Plasmin
2812:Trypsin
2171:9477945
2141:9373149
2112:9174342
2082:8881771
2073:1456645
2039:8635594
2017:Bibcode
1996:8227070
1961:8162045
1932:8125298
1903:6303394
1874:6282262
1865:1163609
1831:3036070
1822:1147622
1788:3030286
1779:1147487
1745:3021205
1708:2834284
1670:2820791
1648:Bibcode
1627:2541966
1597:2372546
1568:1533159
1538:1370572
1373:3052276
1338:3021205
1303:6281620
1227:Ensembl
1206:Ensembl
1178:cleaves
1107:of the
1101:protein
1099:) is a
866:UniProt
817:Ensembl
756:Species
735:QuickGO
399:pattern
157:3779804
125:Aliases
3215:Portal
3157:Reelin
3099:Ancrod
3056:Other
2790:3.4.21
2489:Middle
2211:(MeSH)
2185:Human
2169:
2139:
2110:
2080:
2070:
2045:
2037:
1994:
1959:
1930:
1901:
1872:
1862:
1829:
1819:
1786:
1776:
1743:
1714:
1706:
1676:
1668:
1625:
1595:
1566:
1536:
1509:737019
1507:
1467:
1426:
1371:
1336:
1301:
1291:
1176:. C1r
1135:enzyme
1034:search
1032:PubMed
899:Q8CFG9
880:P00736
805:667277
772:Entrez
570:BioGPS
540:spleen
149:613785
3311:This
3258:is a
3166:Furin
3113:Other
3040:MASP2
3035:MASP1
2965:KLK15
2960:KLK14
2955:KLK13
2950:KLK12
2945:KLK11
2940:KLK10
2683:CD11c
2679:CD11b
2455:MASP2
2451:MASP1
2392:Early
2043:S2CID
1712:S2CID
1674:S2CID
1172:with
765:Mouse
760:Human
731:Amigo
532:ovary
528:liver
422:Mouse
415:Human
362:Start
297:Mouse
261:Start
194:Human
3317:stub
3260:stub
3252:gene
3180:TPP1
3030:MASP
2935:KLK9
2930:KLK8
2925:KLK7
2920:KLK6
2915:KLK5
2910:KLK4
2905:KLK3
2900:KLK2
2895:KLK1
2687:CD18
2631:C4BP
2616:CD59
2604:CLA:
2550:Late
2510:iC3b
2308:1md8
2293:1md7
2278:1gpz
2263:1apq
2167:PMID
2137:PMID
2121:Gene
2108:PMID
2078:PMID
2035:PMID
1992:PMID
1957:PMID
1928:PMID
1912:Gene
1899:PMID
1870:PMID
1827:PMID
1784:PMID
1741:PMID
1704:PMID
1666:PMID
1623:PMID
1593:PMID
1564:PMID
1534:PMID
1505:PMID
1465:PMID
1424:PMID
1369:PMID
1334:PMID
1299:PMID
1289:ISBN
1158:gene
1125:and
1116:gene
405:Bgee
353:Band
314:Chr.
252:Band
211:Chr.
165:1313
145:OMIM
102:2QY0
98:1MD8
94:1MD7
90:1GPZ
86:1APQ
67:RCSB
64:PDBe
3170:S1P
2890:PSA
2702:C5a
2697:C3a
2674:CR4
2669:CR3
2664:CR2
2659:CR1
2628:CL:
2562:C5b
2557:MAC
2527:C5b
2522:C5a
2506:C3b
2501:C3a
2460:MBL
2434:C4b
2429:C4a
2417:C1s
2412:C1r
2407:C1q
2194:C1R
2188:C1R
2159:doi
2129:doi
2125:200
2100:doi
2068:PMC
2025:doi
2013:386
1982:doi
1978:268
1949:doi
1920:doi
1916:138
1891:doi
1860:PMC
1852:doi
1848:201
1817:PMC
1809:doi
1805:241
1774:PMC
1766:doi
1762:240
1733:doi
1696:doi
1656:doi
1644:222
1615:doi
1585:doi
1556:doi
1526:doi
1497:doi
1455:doi
1451:165
1414:doi
1410:274
1361:doi
1326:doi
1281:doi
1174:C1s
1155:CR1
1127:C1s
1123:C1q
1113:C1R
1096:C1r
786:715
578:n/a
375:End
274:End
177:OMA
173:C1R
153:MGI
132:C1R
57:PDB
33:C1R
18:C1R
3362::
2787:EC
2781::
2638:A:
2582:C9
2577:C8
2572:C7
2567:C6
2517:C5
2496:C3
2467:A:
2448:L:
2441:C2
2424:C4
2402:C1
2399:C:
2165:.
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2096:36
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1080:EC
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