315:
1192:. Also, C4 and C2 cleavage goes unchecked, resulting in auto-activation of the complement system. In its most common form, it presents as marked swelling of the face, mouth and/or airway that occurs spontaneously or to minimal triggers (such as mild trauma), but such swelling can occur in any part of the body. In 85% of the cases, the levels of C1-inhibitor are low, while in 15% the protein circulates in normal amounts but it is dysfunctional. In addition to the episodes of facial swelling and/or abdominal pain, it also predisposes to
292:
189:
214:
566:
1581:(the most commonly used organism for this purpose) lacks the eukaryotic ability to glycosylate proteins; as C1-inhibitor is particularly heavily glycosylated, this sialylated recombinant form would have a short circulatory life (the carbohydrates are not relevant to the inhibitor function). Therefore, C1-inhibitor has also been produced in glycosylated form using transgenic rabbits. This form of recombinant C1-inhibitor also has been given
321:
220:
3567:
1553:, a pharmaceutical-grade C1-inhibitor, was approved for the use of HAE in 2008 in the US after having been available in Europe for decades. It is a highly purified, pasteurized and nanofiltered plasma-derived C1 esterase inhibitor product; it has been approved for routine prophylaxis against angioedema attacks in adolescent and adult patients with HAE.
4357:
68:
42:
1188:("hereditary angioneurotic edema"), or swelling due to leakage of fluid from blood vessels into connective tissue. Deficiency of C1-inhibitor permits plasma kallikrein activation, which leads to the production of the vasoactive peptide
2191:
2507:
Caliezi C, Wuillemin WA, Zeerleder S, Redondo M, Eisele B, Hack CE (March 2000). "C1-Esterase inhibitor: an anti-inflammatory agent and its potential use in the treatment of diseases other than hereditary angioedema".
3839:
3218:
Tosi M, Duponchel C, Bourgarel P, Colomb M, Meo T (1986). "Molecular cloning of human C1 inhibitor: sequence homologies with alpha 1-antitrypsin and other members of the serpins superfamily".
4392:
2250:
1329:
3328:
2202:
2872:
Carter PE, Duponchel C, Tosi M, Fothergill JE (April 1991). "Complete nucleotide sequence of the gene for human C1 inhibitor with an unusually high density of Alu elements".
2669:
Davis AE, Aulak K, Parad RB, Stecklein HP, Eldering E, Hack CE, et al. (August 1992). "C1 inhibitor hinge region mutations produce dysfunction by different mechanisms".
1877:
Carter PE, Duponchel C, Tosi M, Fothergill JE (April 1991). "Complete nucleotide sequence of the gene for human C1 inhibitor with an unusually high density of Alu elements".
1556:
A recombinant C1-inhibitor obtained from the milk of transgenic rabbits, conestat alfa (brand name
Ruconest), is approved for the treatment of acute HAE attacks in adults.
328:
227:
3908:
2053:
1593:
The activation of the complement cascade can cause damage to cells, therefore the inhibition of the complement cascade can work as a medicine in certain conditions.
1571:. Risks of infectious disease transmission (viruses, prions, etc.) and relative expense of isolation prevented widespread use. It is also possible to produce it by
1247:
2792:
Siddique Z, McPhaden AR, Lappin DF, Whaley K (December 1991). "An RNA splice site mutation in the C1-inhibitor gene causes type I hereditary angio-oedema".
3940:
3099:"Identification of a new P1 residue mutation (444Arg----Ser) in a dysfunctional C1 inhibitor protein contained in a type II hereditary angioedema plasma"
834:
815:
150:
3321:
2640:
Siddique Z, McPhaden AR, McCluskey D, Whaley K (1992). "A single base deletion from the C1-inhibitor gene causes type I hereditary angio-oedema".
2257:
1739:
3009:"Type II hereditary angioneurotic edema that may result from a single nucleotide change in the codon for alanine-436 in the C1 inhibitor gene"
4377:
3546:
1670:
3675:
1652:
3255:
3060:
Theriault A, Whaley K, McPhaden AR, Boyd E, Connor JM (April 1990). "Regional assignment of the human C1-inhibitor gene to 11q11-q13.1".
1834:
Theriault A, Whaley K, McPhaden AR, Boyd E, Connor JM (April 1990). "Regional assignment of the human C1-inhibitor gene to 11q11-q13.1".
65:
4387:
3314:
3566:
314:
4154:
1042:
2594:
Davis AE, Bissler JJ, Cicardi M (December 1993). "Mutations in the C1 inhibitor gene that result in hereditary angioneurotic edema".
2472:
Bernstein JA (January 2008). "Hereditary angioedema: a current state-of-the-art review, VIII: current status of emerging therapies".
3844:
3786:
3724:
3670:
3665:
3607:
2333:"Self-administered C1 esterase inhibitor concentrates for the management of hereditary angioedema: usability and patient acceptance"
1049:
291:
1152:) is not essential for C1-inhibitor to inhibit proteases. This domain has no similarity to other proteins. C1-inhibitor is highly
2384:"Update on the Use of C1-Esterase Inhibitor Replacement Therapy in the Acute and Prophylactic Treatment of Hereditary Angioedema"
3933:
1912:
Davis AE (January 2008). "Hereditary angioedema: a current state-of-the-art review, III: mechanisms of hereditary angioedema".
1639:
1618:
1369:
1285:
3261:
3973:
1791:
Cicardi M, Zingale L, Zanichelli A, Pappalardo E, Cicardi B (November 2005). "C1 inhibitor: molecular and clinical aspects".
213:
188:
1635:
4347:
1998:"Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases"
1614:
3963:
2197:
1489:
1144:
serpin domain is similar to other serpins, which is the part of C1-inhibitor that provides the inhibitory activity. The
1113:
327:
226:
130:
1304:
3376:
2557:
Stein PE, Carrell RW (February 1995). "What do dysfunctional serpins tell us about molecular mobility and disease?".
320:
219:
2831:"Nonsense mutations affect C1 inhibitor messenger RNA levels in patients with type I hereditary angioneurotic edema"
2284:"Training patients for self-administration of a new subcutaneous C1-inhibitor concentrate for hereditary angioedema"
1549:
Blood-derived C1-inhibitor is effective but does carry the risk associated with the use of any human blood product.
4382:
3926:
3885:
3487:
1200:, due to its consumptive effect on complement factors 3 and 4. Mutations in the gene that codes for C1-inhibitor,
4209:
3539:
3692:
3630:
3482:
3472:
879:
138:
4289:
4159:
4124:
4119:
4014:
4009:
4004:
1949:"Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study"
1315:
860:
4179:
4169:
4164:
4114:
4093:
4038:
4021:
2956:"Clusters of intragenic Alu repeats predispose the human C1 inhibitor locus to deleterious rearrangements"
1559:
Other products also have been introduced including plasma-derived products such as
Berinert and Haegarda.
2431:
Koles K, van Berkel PH, Pieper FR, Nuijens JH, Mannesse ML, Vliegenthart JF, et al. (January 2004).
1267:
4261:
4256:
4057:
3865:
3811:
3600:
3403:
2540:
Lappin D, Whaley K (July 1989). "Regulation of C1-inhibitor synthesis by interferons and other agents".
1733:
1185:
202:
2903:"Dysfunctional C1 inhibitor Ta: deletion of Lys-251 results in acquisition of an N-glycosylation site"
1585:
status for delayed graft function following organ transplantation and for capillary leakage syndrome.
4271:
4266:
3532:
3020:
2967:
2914:
2009:
1205:
117:
4248:
4228:
4218:
4067:
3781:
3682:
3660:
3655:
3640:
3635:
3454:
3267:
1435:
1260:
1197:
1004:
949:
3367:
3128:
3085:
2817:
2737:
2694:
2582:
2413:
1859:
1816:
1193:
162:
2433:"N- and O-glycans of recombinant human C1 inhibitor expressed in the milk of transgenic rabbits"
2081:
1136:
superfamily of proteins. It can be noted that, unlike most family members, C1-inhibitor has a 2-
1025:
1000:
974:
953:
3177:"Type I C1 inhibitor deficiency with a small messenger RNA resulting from deletion of one exon"
565:
3949:
3286:
3235:
3206:
3163:
3120:
3077:
3048:
2995:
2942:
2889:
2860:
2809:
2780:
2729:
2686:
2657:
2628:
2599:
2574:
2545:
2517:
2489:
2454:
2405:
2364:
2313:
2035:
1978:
1929:
1894:
1851:
1808:
1770:
1721:
1408:
1395:
1383:
1229:
1121:
158:
110:
58:
2708:"A dysfunctional C1 inhibitor protein with a new reactive center mutation (Arg-444-->Leu)"
2165:
1444:
4323:
4276:
4098:
3593:
3459:
3227:
3196:
3188:
3153:
3110:
3069:
3038:
3028:
2985:
2975:
2932:
2922:
2881:
2850:
2842:
2801:
2770:
2762:
2719:
2678:
2649:
2620:
2566:
2481:
2444:
2395:
2354:
2344:
2303:
2295:
2025:
2017:
1968:
1960:
1921:
1886:
1843:
1800:
1762:
1711:
1701:
1577:
407:
338:
282:
237:
1505:
1498:
1451:
4361:
4052:
4048:
3890:
1572:
382:
1124:
to prevent spontaneous activation but also as the major regulator of the contact system.
3024:
2971:
2918:
2013:
3968:
3712:
2885:
2775:
2750:
2359:
2332:
2308:
2283:
2282:
Murphy E, Donahue C, Omert L, Persons S, Tyma TJ, Chiao J, et al. (January 2019).
2030:
1997:
1973:
1948:
1890:
1716:
1689:
1568:
1156:, bearing both N- and O-glycans. N-terminal domain is especially heavily glycosylated.
1137:
3201:
3176:
3158:
3141:
2855:
2830:
2485:
1964:
1947:
Ennis S, Jomary C, Mullins R, Cree A, Chen X, Macleod A, et al. (November 2008).
1925:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
658:
653:
648:
643:
638:
633:
617:
612:
607:
4371:
4138:
4133:
3477:
3428:
3387:
3382:
3295:
3231:
3115:
3098:
3043:
3008:
2990:
2955:
2937:
2902:
2724:
2707:
2136:
2110:
2058:
1347:
1153:
594:
17:
3132:
3089:
2821:
2741:
2698:
2586:
2417:
1863:
1820:
4334:
4329:
4317:
4299:
4294:
3776:
3645:
3463:
3418:
3409:
3372:
3362:
3348:
3338:
3306:
3278:
3273:
1352:
1342:
1337:
400:
179:
142:
2751:"Effect of interferon-gamma on complement gene expression in different cell types"
1567:
C1-inhibitor is contained in the human blood; it can, therefore, be isolated from
3140:
Skriver K, Radziejewska E, Silbermann JA, Donaldson VH, Bock SC (February 1989).
1766:
1688:
Law RH, Zhang Q, McGowan S, Buckle AM, Silverman GA, Wong W, et al. (2006).
166:
3880:
3443:
3433:
1675:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1657:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1582:
1322:
3013:
Proceedings of the
National Academy of Sciences of the United States of America
2960:
Proceedings of the
National Academy of Sciences of the United States of America
2907:
Proceedings of the
National Academy of Sciences of the United States of America
2829:
Frangi D, Cicardi M, Sica A, Colotta F, Agostoni A, Davis AE (September 1991).
2624:
2224:
2021:
1274:
483:
4174:
3999:
2400:
2383:
1804:
1189:
1173:
1145:
1141:
299:
196:
146:
4077:
3875:
3769:
3764:
3497:
3492:
3438:
3357:
2927:
2449:
2432:
1706:
1251:
1217:
1208:. At least 97 disease-causing mutations in this gene have been discovered.
779:
543:
421:
366:
353:
265:
252:
154:
2980:
2632:
2521:
2493:
2458:
2409:
2368:
2317:
2039:
1982:
1933:
1812:
1774:
1725:
3239:
3210:
3167:
3124:
3081:
3052:
3033:
2999:
2946:
2893:
2864:
2813:
2784:
2733:
2690:
2661:
2603:
2578:
2549:
1898:
1855:
1089:
1084:
41:
4238:
4072:
3821:
3816:
3801:
3796:
3791:
3759:
3754:
3749:
3744:
3734:
3729:
3719:
3707:
3702:
3697:
3687:
3175:
Ariga T, Igarashi T, Ramesh N, Parad R, Cicardi M, Davis AE (June 1989).
2611:
Davis AE (January 2005). "The pathophysiology of hereditary angioedema".
1462:
1299:
1073:
924:
905:
1478:
1471:
3392:
3300:
3290:
3073:
2805:
2682:
2570:
2349:
1847:
891:
846:
3192:
2846:
2766:
2653:
87:
3870:
3831:
3739:
3616:
2299:
1117:
1057:
801:
3918:
3007:
Levy NJ, Ramesh N, Cicardi M, Harrison RA, Davis AE (January 1990).
2901:
Parad RB, Kramer J, Strunk RC, Rosen FS, Davis AE (September 1990).
2706:
Frangi D, Aulak KS, Cicardi M, Harrison RA, Davis AE (April 1992).
1532:
1525:
4280:
3513:
1753:
Davis AE (September 2004). "Biological effects of C1 inhibitor".
764:
760:
4284:
4213:
4107:
3895:
3849:
1516:
1414:
1389:
1165:
134:
3922:
3589:
3528:
3310:
2111:"Ruconest 2100 U powder and solvent for solution for injection"
1402:
1294:
4103:
4031:
4026:
3524:
2749:
Lappin DF, Guc D, Hill A, McShane T, Whaley K (January 1992).
574:
3285:
Overview of all the structural information available in the
2954:
Stoppa-Lyonnet D, Carter PE, Meo T, Tosi M (February 1990).
715:
negative regulation of complement activation, lectin pathway
3585:
3142:"CpG mutations in the reactive site of human C1 inhibitor"
1204:, may also play a role in the development of age-related
121:, C1IN, C1INH, C1NH, HAE1, HAE2, serpin family G member 1
1378:
1120:
superfamily. Its main function is the inhibition of the
390:
2105:
2103:
4345:
555:
4310:
4247:
4194:
4147:
4086:
3989:
3982:
3956:
3858:
3830:
3623:
3506:
3452:
3401:
3346:
2137:"Ruconest 2100 U powder for solution for injection"
1515:
1488:
1461:
1434:
1429:
1368:
1363:
1328:
1314:
1284:
1246:
1238:
1228:
1223:
1018:
993:
967:
942:
1631:
1629:
1627:
1610:
1608:
1606:
2251:"Summary of product characteristics for Ruconest"
337:
236:
4393:Drugs developed by Takeda Pharmaceutical Company
3575:: Crystal structure of latent human C1-inhibitor
2160:
2158:
1450:
1443:
3097:Aulak KS, Cicardi M, Harrison RA (June 1990).
1786:
1784:
1636:GRCm38: Ensembl release 89: ENSMUSG00000023224
1184:Deficiency of this protein is associated with
3934:
3601:
3540:
3322:
2382:Henry Li H, Riedl M, Kashkin J (April 2019).
1132:C1-inhibitor is the largest member among the
730:negative regulation of endopeptidase activity
8:
2388:Clinical Reviews in Allergy & Immunology
1303:
1216:
750:negative regulation of complement activation
618:serine-type endopeptidase inhibitor activity
1615:GRCh38: Ensembl release 89: ENSG00000149131
1422:In general: ℞ (Prescription only)
1148:domain (also some times referred to as the
3986:
3941:
3927:
3919:
3608:
3594:
3586:
3547:
3533:
3525:
3329:
3315:
3307:
2474:Annals of Allergy, Asthma & Immunology
2082:"Regulatory Decision Summary for Haegarda"
1914:Annals of Allergy, Asthma & Immunology
775:
590:
378:
277:
174:
76:
3909:disorders of globin and globulin proteins
3200:
3157:
3114:
3042:
3032:
2989:
2979:
2936:
2926:
2854:
2774:
2723:
2448:
2399:
2358:
2348:
2307:
2029:
1996:Šimčíková D, Heneberg P (December 2019).
1972:
1715:
1705:
1504:
1497:
685:negative regulation of peptidase activity
720:complement activation, classical pathway
659:collagen-containing extracellular matrix
4352:
3562:
1690:"An overview of the serpin superfamily"
1602:
1477:
1470:
3299:(Plasma protease C1 inhibitor) at the
1731:
1215:
31:
3181:The Journal of Clinical Investigation
2835:The Journal of Clinical Investigation
2225:"Cinryze Monograph for Professionals"
1273:
1266:
1259:
342:
303:
298:
241:
200:
195:
7:
3676:Protein Z-related protease inhibitor
3277:
1793:Springer Seminars in Immunopathology
1351:
1341:
680:blood coagulation, intrinsic pathway
3146:The Journal of Biological Chemistry
1531:
1524:
1234:Cinryze, Ruconest, Berinert, others
740:regulation of complement activation
2886:10.1111/j.1432-1033.1991.tb15911.x
1891:10.1111/j.1432-1033.1991.tb15911.x
1738:: CS1 maint: overridden setting (
1015:
990:
964:
939:
915:
896:
870:
851:
825:
806:
560:
478:
416:
395:
25:
3671:Plasminogen activator inhibitor-2
3666:Plasminogen activator inhibitor-1
27:Mammalian protein found in humans
4355:
3565:
2874:European Journal of Biochemistry
2337:Patient Preference and Adherence
1879:European Journal of Biochemistry
564:
326:
319:
313:
290:
225:
218:
212:
187:
40:
2170:European Medicines Agency (EMA)
2086:Drug and Health Products Portal
745:regulation of blood coagulation
2596:Behring Institute Mitteilungen
2542:Behring Institute Mitteilungen
2201:. 12 July 2017. Archived from
575:More reference expression data
544:More reference expression data
1:
3159:10.1016/S0021-9258(18)94031-7
2486:10.1016/S1081-1206(10)60585-6
1965:10.1016/S0140-6736(08)61348-3
1926:10.1016/S1081-1206(10)60580-7
1172:) is located on the eleventh
311:
210:
4378:Genes on human chromosome 11
3337:Other hematological agents (
3232:10.1016/0378-1119(86)90230-1
3116:10.1016/0014-5793(90)81494-9
2725:10.1016/0014-5793(92)80204-T
2198:Food and Drug Administration
1767:10.1358/dnp.2004.17.7.863703
1755:Drug News & Perspectives
649:platelet alpha granule lumen
608:peptidase inhibitor activity
1275:Multum Consumer Information
4409:
4388:Serine protease inhibitors
3886:Thyroxine-binding globulin
3488:Lovotibeglogene autotemcel
3266:gene details page in the
2625:10.1016/j.clim.2004.05.007
2331:Li HH (7 September 2016).
2022:10.1038/s41598-019-54976-4
4210:Decay-accelerating factor
3904:
3560:
2559:Nature Structural Biology
2401:10.1007/s12016-018-8684-1
1805:10.1007/s00281-005-0001-4
1671:"Mouse PubMed Reference:"
1653:"Human PubMed Reference:"
1088:
1083:
1079:
1072:
1056:
1037:
1022:
997:
986:
971:
946:
935:
922:
918:
903:
899:
890:
877:
873:
858:
854:
845:
832:
828:
813:
809:
800:
785:
778:
774:
758:
593:
589:
572:
563:
554:
541:
490:
481:
448:Descending thoracic aorta
428:
419:
389:
381:
377:
360:
347:
310:
289:
280:
276:
259:
246:
209:
186:
177:
173:
128:
125:
115:
108:
103:
84:
79:
62:
57:
52:
48:
39:
34:
3631:Alpha 1-antichymotrypsin
3483:Exagamglogene autotemcel
3473:Betibeglogene autotemcel
2928:10.1073/pnas.87.17.6786
2755:The Biochemical Journal
2510:Pharmacological Reviews
1707:10.1186/gb-2006-7-5-216
1164:The human C1-inhibitor
1043:Chr 11: 57.6 – 57.62 Mb
3832:Cross class inhibitory
2981:10.1073/pnas.87.4.1551
1050:Chr 2: 84.6 – 84.61 Mb
725:innate immune response
705:platelet degranulation
3866:Heat shock protein 47
3034:10.1073/pnas.87.1.265
2450:10.1093/glycob/cwh010
1545:Hereditary angioedema
1186:hereditary angioedema
1110:C1 esterase inhibitor
695:immune system process
644:extracellular exosome
440:right coronary artery
203:Chromosome 11 (human)
18:C1 esterase inhibitor
4249:Complement receptors
3260:genome location and
2480:(1 Suppl 2): S41-6.
2263:on 20 September 2018
1920:(1 Suppl 2): S7-12.
1206:macular degeneration
639:extracellular region
526:white adipose tissue
305:Chromosome 2 (mouse)
167:SERPING1 - orthologs
80:List of PDB id codes
53:Available structures
3661:Protein C inhibitor
3656:Heparin cofactor II
3641:Alpha 2-antiplasmin
3636:Alpha 1-antitrypsin
3455:sickle cell disease
3377:+desoxyribonuclease
3268:UCSC Genome Browser
3025:1990PNAS...87..265L
2972:1990PNAS...87.1551S
2919:1990PNAS...87.6786P
2613:Clinical Immunology
2054:"Genetic disorders"
2014:2019NatSR...918577S
1398:(Prescription only)
1220:
1198:lupus erythematosus
1194:autoimmune diseases
654:extracellular space
634:blood microparticle
432:right lobe of liver
4078:Factor P/Properdin
3983:Activators/enzymes
3368:Desoxyribonuclease
3074:10.1007/BF00195824
2806:10.1007/bf00206079
2683:10.1038/ng0892-354
2571:10.1038/nsb0295-96
2350:10.2147/PPA.S86379
2231:. 23 December 2019
2088:. 1 September 2017
2002:Scientific Reports
1848:10.1007/BF00195824
1114:protease inhibitor
880:ENSMUSG00000023224
668:Biological process
627:Cellular component
601:Molecular function
494:left lobe of liver
4383:Complement system
4343:
4342:
4190:
4189:
3950:Complement system
3916:
3915:
3583:
3582:
3522:
3521:
3193:10.1172/JCI114095
2847:10.1172/JCI115373
2767:10.1042/bj2810437
2654:10.1159/000154075
2172:. 28 October 2010
1959:(9652): 1828–34.
1542:
1541:
1418:
1406:
1393:
1381:
1297:
1242:RVG-19303, CSL830
1122:complement system
1116:belonging to the
1099:
1098:
1095:
1094:
1068:
1067:
1033:
1032:
1012:
1011:
982:
981:
961:
960:
931:
930:
912:
911:
886:
885:
867:
866:
841:
840:
822:
821:
770:
769:
735:blood coagulation
710:blood circulation
585:
584:
581:
580:
550:
549:
537:
536:
475:
474:
464:left uterine tube
373:
372:
272:
271:
99:
98:
95:
94:
63:Ortholog search:
16:(Redirected from
4400:
4360:
4359:
4358:
4351:
4324:immune adherence
3987:
3943:
3936:
3929:
3920:
3610:
3603:
3596:
3587:
3569:
3549:
3542:
3535:
3526:
3460:beta thalassemia
3331:
3324:
3317:
3308:
3281:
3243:
3214:
3204:
3171:
3161:
3136:
3118:
3093:
3056:
3046:
3036:
3003:
2993:
2983:
2950:
2940:
2930:
2897:
2868:
2858:
2825:
2788:
2778:
2761:(Pt 2): 437–42.
2745:
2727:
2702:
2665:
2636:
2607:
2590:
2553:
2526:
2525:
2504:
2498:
2497:
2469:
2463:
2462:
2452:
2428:
2422:
2421:
2403:
2379:
2373:
2372:
2362:
2352:
2328:
2322:
2321:
2311:
2300:10.1002/nop2.194
2279:
2273:
2272:
2270:
2268:
2262:
2256:. Archived from
2255:
2247:
2241:
2240:
2238:
2236:
2221:
2215:
2214:
2212:
2210:
2188:
2182:
2181:
2179:
2177:
2162:
2153:
2152:
2150:
2148:
2143:. 30 August 2023
2133:
2127:
2126:
2124:
2122:
2117:. 30 August 2023
2107:
2098:
2097:
2095:
2093:
2078:
2072:
2071:
2069:
2067:
2050:
2044:
2043:
2033:
1993:
1987:
1986:
1976:
1944:
1938:
1937:
1909:
1903:
1902:
1874:
1868:
1867:
1831:
1825:
1824:
1788:
1779:
1778:
1750:
1744:
1743:
1737:
1729:
1719:
1709:
1685:
1679:
1678:
1667:
1661:
1660:
1649:
1643:
1633:
1622:
1612:
1578:Escherichia coli
1575:technology, but
1535:
1528:
1508:
1501:
1481:
1474:
1454:
1447:
1416:
1413:
1404:
1401:
1391:
1388:
1380:
1377:
1355:
1345:
1307:
1296:
1293:
1277:
1270:
1263:
1221:
1219:
1196:, most markedly
1081:
1080:
1052:
1045:
1028:
1016:
1007:
991:
987:RefSeq (protein)
977:
965:
956:
940:
916:
897:
871:
852:
826:
807:
776:
591:
577:
568:
561:
546:
522:efferent ductule
486:
484:Top expressed in
479:
456:popliteal artery
424:
422:Top expressed in
417:
396:
379:
369:
356:
345:
330:
323:
317:
306:
294:
278:
268:
255:
244:
229:
222:
216:
205:
191:
175:
169:
120:
113:
90:
77:
71:
50:
49:
44:
32:
21:
4408:
4407:
4403:
4402:
4401:
4399:
4398:
4397:
4368:
4367:
4366:
4356:
4354:
4346:
4344:
4339:
4306:
4243:
4186:
4143:
4082:
3978:
3952:
3947:
3917:
3912:
3900:
3891:Angiotensinogen
3854:
3826:
3619:
3614:
3584:
3579:
3576:
3570:
3556:
3553:
3523:
3518:
3502:
3457:
3448:
3405:
3397:
3342:
3335:
3251:
3246:
3217:
3174:
3139:
3096:
3059:
3006:
2953:
2913:(17): 6786–90.
2900:
2871:
2828:
2791:
2748:
2705:
2671:Nature Genetics
2668:
2639:
2610:
2593:
2556:
2539:
2535:
2533:Further reading
2530:
2529:
2506:
2505:
2501:
2471:
2470:
2466:
2430:
2429:
2425:
2381:
2380:
2376:
2330:
2329:
2325:
2281:
2280:
2276:
2266:
2264:
2260:
2253:
2249:
2248:
2244:
2234:
2232:
2223:
2222:
2218:
2208:
2206:
2205:on 22 July 2017
2190:
2189:
2185:
2175:
2173:
2166:"Ruconest EPAR"
2164:
2163:
2156:
2146:
2144:
2135:
2134:
2130:
2120:
2118:
2109:
2108:
2101:
2091:
2089:
2080:
2079:
2075:
2065:
2063:
2052:
2051:
2047:
1995:
1994:
1990:
1946:
1945:
1941:
1911:
1910:
1906:
1876:
1875:
1871:
1833:
1832:
1828:
1790:
1789:
1782:
1752:
1751:
1747:
1730:
1687:
1686:
1682:
1669:
1668:
1664:
1651:
1650:
1646:
1634:
1625:
1613:
1604:
1599:
1591:
1565:
1547:
1538:
1511:
1484:
1457:
1425:
1359:
1317:
1310:
1280:
1214:
1182:
1180:Role in disease
1176:(11q11-q13.1).
1162:
1150:N-terminal tail
1140:structure. The
1130:
1090:View/Edit Mouse
1085:View/Edit Human
1048:
1041:
1038:Location (UCSC)
1024:
1003:
999:
973:
952:
948:
861:ENSG00000149131
754:
663:
622:
613:protein binding
573:
542:
533:
528:
524:
520:
518:right lung lobe
516:
512:
508:
504:
500:
496:
482:
471:
466:
462:
460:tibial arteries
458:
454:
452:ascending aorta
450:
446:
442:
438:
434:
420:
364:
351:
343:
333:
332:
331:
324:
304:
281:Gene location (
263:
250:
242:
232:
231:
230:
223:
201:
178:Gene location (
129:
116:
109:
86:
64:
28:
23:
22:
15:
12:
11:
5:
4406:
4404:
4396:
4395:
4390:
4385:
4380:
4370:
4369:
4365:
4364:
4341:
4340:
4338:
4337:
4332:
4326:
4321:
4314:
4312:
4308:
4307:
4305:
4304:
4303:
4302:
4297:
4287:
4274:
4269:
4264:
4259:
4253:
4251:
4245:
4244:
4242:
4241:
4232:
4231:
4222:
4221:
4216:
4207:
4198:
4196:
4192:
4191:
4188:
4187:
4185:
4184:
4183:
4182:
4177:
4172:
4167:
4162:
4151:
4149:
4145:
4144:
4142:
4141:
4136:
4130:
4129:
4128:
4127:
4122:
4112:
4111:
4110:
4101:
4090:
4088:
4084:
4083:
4081:
4080:
4075:
4070:
4061:
4060:
4055:
4042:
4041:
4036:
4035:
4034:
4029:
4019:
4018:
4017:
4012:
4007:
3993:
3991:
3984:
3980:
3979:
3977:
3976:
3971:
3966:
3960:
3958:
3954:
3953:
3948:
3946:
3945:
3938:
3931:
3923:
3914:
3913:
3905:
3902:
3901:
3899:
3898:
3893:
3888:
3883:
3878:
3873:
3868:
3862:
3860:
3856:
3855:
3853:
3852:
3847:
3842:
3836:
3834:
3828:
3827:
3825:
3824:
3819:
3814:
3809:
3804:
3799:
3794:
3789:
3784:
3779:
3773:
3772:
3767:
3762:
3757:
3752:
3747:
3742:
3737:
3732:
3727:
3722:
3716:
3715:
3710:
3705:
3700:
3695:
3690:
3685:
3679:
3678:
3673:
3668:
3663:
3658:
3653:
3648:
3643:
3638:
3633:
3627:
3625:
3621:
3620:
3615:
3613:
3612:
3605:
3598:
3590:
3581:
3580:
3578:
3577:
3571:
3564:
3561:
3558:
3557:
3554:
3552:
3551:
3544:
3537:
3529:
3520:
3519:
3517:
3516:
3510:
3508:
3504:
3503:
3501:
3500:
3495:
3490:
3485:
3480:
3475:
3469:
3467:
3453:Drugs used in
3450:
3449:
3447:
3446:
3441:
3436:
3431:
3426:
3421:
3415:
3413:
3402:Drugs used in
3399:
3398:
3396:
3395:
3390:
3385:
3380:
3370:
3365:
3360:
3354:
3352:
3344:
3343:
3336:
3334:
3333:
3326:
3319:
3311:
3305:
3304:
3283:
3271:
3250:
3249:External links
3247:
3245:
3244:
3215:
3187:(6): 1888–93.
3172:
3152:(6): 3066–71.
3137:
3094:
3062:Human Genetics
3057:
3004:
2951:
2898:
2869:
2826:
2794:Human Genetics
2789:
2746:
2703:
2666:
2642:Human Heredity
2637:
2608:
2598:(93): 313–20.
2591:
2554:
2544:(84): 180–92.
2536:
2534:
2531:
2528:
2527:
2499:
2464:
2423:
2394:(2): 207–218.
2374:
2323:
2294:(1): 126–135.
2274:
2242:
2216:
2183:
2154:
2128:
2099:
2073:
2045:
1988:
1939:
1904:
1869:
1836:Human Genetics
1826:
1780:
1745:
1694:Genome Biology
1680:
1662:
1644:
1623:
1601:
1600:
1598:
1595:
1590:
1587:
1564:
1561:
1546:
1543:
1540:
1539:
1537:
1536:
1529:
1521:
1519:
1513:
1512:
1510:
1509:
1502:
1494:
1492:
1486:
1485:
1483:
1482:
1475:
1467:
1465:
1459:
1458:
1456:
1455:
1448:
1440:
1438:
1432:
1431:
1427:
1426:
1424:
1423:
1420:
1411:
1399:
1386:
1374:
1372:
1366:
1365:
1361:
1360:
1358:
1357:
1334:
1332:
1326:
1325:
1320:
1318:administration
1312:
1311:
1309:
1308:
1290:
1288:
1282:
1281:
1279:
1278:
1271:
1264:
1256:
1254:
1244:
1243:
1240:
1236:
1235:
1232:
1226:
1225:
1213:
1210:
1181:
1178:
1161:
1158:
1129:
1126:
1097:
1096:
1093:
1092:
1087:
1077:
1076:
1070:
1069:
1066:
1065:
1063:
1061:
1054:
1053:
1046:
1039:
1035:
1034:
1031:
1030:
1020:
1019:
1013:
1010:
1009:
995:
994:
988:
984:
983:
980:
979:
969:
968:
962:
959:
958:
944:
943:
937:
933:
932:
929:
928:
920:
919:
913:
910:
909:
901:
900:
894:
888:
887:
884:
883:
875:
874:
868:
865:
864:
856:
855:
849:
843:
842:
839:
838:
830:
829:
823:
820:
819:
811:
810:
804:
798:
797:
792:
787:
783:
782:
772:
771:
768:
767:
756:
755:
753:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
682:
677:
671:
669:
665:
664:
662:
661:
656:
651:
646:
641:
636:
630:
628:
624:
623:
621:
620:
615:
610:
604:
602:
598:
597:
587:
586:
583:
582:
579:
578:
570:
569:
558:
552:
551:
548:
547:
539:
538:
535:
534:
532:
531:
527:
523:
519:
515:
511:
507:
503:
499:
495:
491:
488:
487:
476:
473:
472:
470:
469:
465:
461:
457:
453:
449:
445:
444:gastric mucosa
441:
437:
433:
429:
426:
425:
413:
412:
404:
393:
387:
386:
383:RNA expression
375:
374:
371:
370:
362:
358:
357:
349:
346:
341:
335:
334:
325:
318:
312:
308:
307:
302:
296:
295:
287:
286:
274:
273:
270:
269:
261:
257:
256:
248:
245:
240:
234:
233:
224:
217:
211:
207:
206:
199:
193:
192:
184:
183:
171:
170:
127:
123:
122:
114:
106:
105:
101:
100:
97:
96:
93:
92:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4405:
4394:
4391:
4389:
4386:
4384:
4381:
4379:
4376:
4375:
4373:
4363:
4353:
4349:
4336:
4333:
4331:
4327:
4325:
4322:
4319:
4316:
4315:
4313:
4309:
4301:
4298:
4296:
4293:
4292:
4291:
4290:Anaphylatoxin
4288:
4286:
4282:
4278:
4275:
4273:
4270:
4268:
4265:
4263:
4260:
4258:
4255:
4254:
4252:
4250:
4246:
4240:
4237:
4234:
4233:
4230:
4227:
4224:
4223:
4220:
4217:
4215:
4211:
4208:
4206:
4203:
4200:
4199:
4197:
4193:
4181:
4178:
4176:
4173:
4171:
4168:
4166:
4163:
4161:
4158:
4157:
4156:
4153:
4152:
4150:
4146:
4140:
4139:C5-convertase
4137:
4135:
4134:C3-convertase
4132:
4131:
4126:
4123:
4121:
4118:
4117:
4116:
4113:
4109:
4105:
4102:
4100:
4097:
4096:
4095:
4092:
4091:
4089:
4085:
4079:
4076:
4074:
4071:
4069:
4066:
4063:
4062:
4059:
4056:
4054:
4050:
4047:
4044:
4043:
4040:
4037:
4033:
4030:
4028:
4025:
4024:
4023:
4020:
4016:
4013:
4011:
4008:
4006:
4003:
4002:
4001:
3998:
3995:
3994:
3992:
3988:
3985:
3981:
3975:
3972:
3970:
3967:
3965:
3962:
3961:
3959:
3955:
3951:
3944:
3939:
3937:
3932:
3930:
3925:
3924:
3921:
3911:
3910:
3903:
3897:
3894:
3892:
3889:
3887:
3884:
3882:
3879:
3877:
3874:
3872:
3869:
3867:
3864:
3863:
3861:
3859:noninhibitory
3857:
3851:
3848:
3846:
3843:
3841:
3838:
3837:
3835:
3833:
3829:
3823:
3820:
3818:
3815:
3813:
3810:
3808:
3805:
3803:
3800:
3798:
3795:
3793:
3790:
3788:
3785:
3783:
3780:
3778:
3775:
3774:
3771:
3768:
3766:
3763:
3761:
3758:
3756:
3753:
3751:
3748:
3746:
3743:
3741:
3738:
3736:
3733:
3731:
3728:
3726:
3723:
3721:
3718:
3717:
3714:
3711:
3709:
3706:
3704:
3701:
3699:
3696:
3694:
3691:
3689:
3686:
3684:
3681:
3680:
3677:
3674:
3672:
3669:
3667:
3664:
3662:
3659:
3657:
3654:
3652:
3649:
3647:
3644:
3642:
3639:
3637:
3634:
3632:
3629:
3628:
3626:
3622:
3618:
3611:
3606:
3604:
3599:
3597:
3592:
3591:
3588:
3574:
3568:
3563:
3559:
3550:
3545:
3543:
3538:
3536:
3531:
3530:
3527:
3515:
3512:
3511:
3509:
3505:
3499:
3496:
3494:
3491:
3489:
3486:
3484:
3481:
3479:
3478:Crizanlizumab
3476:
3474:
3471:
3470:
3468:
3465:
3461:
3456:
3451:
3445:
3442:
3440:
3437:
3435:
3432:
3430:
3429:Conestat alfa
3427:
3425:
3422:
3420:
3417:
3416:
3414:
3411:
3407:
3400:
3394:
3391:
3389:
3388:Streptokinase
3386:
3384:
3383:Hyaluronidase
3381:
3378:
3374:
3371:
3369:
3366:
3364:
3361:
3359:
3356:
3355:
3353:
3350:
3345:
3340:
3332:
3327:
3325:
3320:
3318:
3313:
3312:
3309:
3302:
3298:
3297:
3292:
3288:
3284:
3280:
3275:
3272:
3269:
3265:
3264:
3259:
3258:
3253:
3252:
3248:
3241:
3237:
3233:
3229:
3226:(3): 265–72.
3225:
3221:
3216:
3212:
3208:
3203:
3198:
3194:
3190:
3186:
3182:
3178:
3173:
3169:
3165:
3160:
3155:
3151:
3147:
3143:
3138:
3134:
3130:
3126:
3122:
3117:
3112:
3109:(1–2): 13–6.
3108:
3104:
3100:
3095:
3091:
3087:
3083:
3079:
3075:
3071:
3067:
3063:
3058:
3054:
3050:
3045:
3040:
3035:
3030:
3026:
3022:
3018:
3014:
3010:
3005:
3001:
2997:
2992:
2987:
2982:
2977:
2973:
2969:
2966:(4): 1551–5.
2965:
2961:
2957:
2952:
2948:
2944:
2939:
2934:
2929:
2924:
2920:
2916:
2912:
2908:
2904:
2899:
2895:
2891:
2887:
2883:
2879:
2875:
2870:
2866:
2862:
2857:
2852:
2848:
2844:
2840:
2836:
2832:
2827:
2823:
2819:
2815:
2811:
2807:
2803:
2799:
2795:
2790:
2786:
2782:
2777:
2772:
2768:
2764:
2760:
2756:
2752:
2747:
2743:
2739:
2735:
2731:
2726:
2721:
2717:
2713:
2709:
2704:
2700:
2696:
2692:
2688:
2684:
2680:
2676:
2672:
2667:
2663:
2659:
2655:
2651:
2647:
2643:
2638:
2634:
2630:
2626:
2622:
2618:
2614:
2609:
2605:
2601:
2597:
2592:
2588:
2584:
2580:
2576:
2572:
2568:
2565:(2): 96–113.
2564:
2560:
2555:
2551:
2547:
2543:
2538:
2537:
2532:
2523:
2519:
2516:(1): 91–112.
2515:
2511:
2503:
2500:
2495:
2491:
2487:
2483:
2479:
2475:
2468:
2465:
2460:
2456:
2451:
2446:
2442:
2438:
2434:
2427:
2424:
2419:
2415:
2411:
2407:
2402:
2397:
2393:
2389:
2385:
2378:
2375:
2370:
2366:
2361:
2356:
2351:
2346:
2342:
2338:
2334:
2327:
2324:
2319:
2315:
2310:
2305:
2301:
2297:
2293:
2289:
2285:
2278:
2275:
2259:
2252:
2246:
2243:
2230:
2226:
2220:
2217:
2204:
2200:
2199:
2193:
2187:
2184:
2171:
2167:
2161:
2159:
2155:
2142:
2138:
2132:
2129:
2116:
2112:
2106:
2104:
2100:
2087:
2083:
2077:
2074:
2061:
2060:
2059:Health Canada
2055:
2049:
2046:
2041:
2037:
2032:
2027:
2023:
2019:
2015:
2011:
2007:
2003:
1999:
1992:
1989:
1984:
1980:
1975:
1970:
1966:
1962:
1958:
1954:
1950:
1943:
1940:
1935:
1931:
1927:
1923:
1919:
1915:
1908:
1905:
1900:
1896:
1892:
1888:
1884:
1880:
1873:
1870:
1865:
1861:
1857:
1853:
1849:
1845:
1841:
1837:
1830:
1827:
1822:
1818:
1814:
1810:
1806:
1802:
1799:(3): 286–98.
1798:
1794:
1787:
1785:
1781:
1776:
1772:
1768:
1764:
1761:(7): 439–46.
1760:
1756:
1749:
1746:
1741:
1735:
1727:
1723:
1718:
1713:
1708:
1703:
1699:
1695:
1691:
1684:
1681:
1676:
1672:
1666:
1663:
1658:
1654:
1648:
1645:
1641:
1637:
1632:
1630:
1628:
1624:
1620:
1616:
1611:
1609:
1607:
1603:
1596:
1594:
1588:
1586:
1584:
1580:
1579:
1574:
1570:
1569:donated blood
1562:
1560:
1557:
1554:
1552:
1544:
1534:
1530:
1527:
1523:
1522:
1520:
1518:
1514:
1507:
1503:
1500:
1496:
1495:
1493:
1491:
1487:
1480:
1476:
1473:
1469:
1468:
1466:
1464:
1460:
1453:
1449:
1446:
1442:
1441:
1439:
1437:
1433:
1428:
1421:
1419: Rx-only
1412:
1410:
1400:
1397:
1387:
1385:
1376:
1375:
1373:
1371:
1367:
1362:
1354:
1349:
1344:
1339:
1336:
1335:
1333:
1331:
1327:
1324:
1321:
1319:
1313:
1306:
1301:
1292:
1291:
1289:
1287:
1283:
1276:
1272:
1269:
1265:
1262:
1258:
1257:
1255:
1253:
1249:
1245:
1241:
1237:
1233:
1231:
1227:
1224:Clinical data
1222:
1211:
1209:
1207:
1203:
1199:
1195:
1191:
1187:
1179:
1177:
1175:
1171:
1167:
1159:
1157:
1155:
1151:
1147:
1143:
1139:
1135:
1127:
1125:
1123:
1119:
1115:
1111:
1107:
1103:
1091:
1086:
1082:
1078:
1075:
1071:
1064:
1062:
1059:
1055:
1051:
1047:
1044:
1040:
1036:
1029:
1027:
1021:
1017:
1014:
1008:
1006:
1002:
996:
992:
989:
985:
978:
976:
970:
966:
963:
957:
955:
951:
945:
941:
938:
936:RefSeq (mRNA)
934:
927:
926:
921:
917:
914:
908:
907:
902:
898:
895:
893:
889:
882:
881:
876:
872:
869:
863:
862:
857:
853:
850:
848:
844:
837:
836:
831:
827:
824:
818:
817:
812:
808:
805:
803:
799:
796:
793:
791:
788:
784:
781:
777:
773:
766:
762:
757:
751:
748:
746:
743:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
681:
678:
676:
673:
672:
670:
667:
666:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
631:
629:
626:
625:
619:
616:
614:
611:
609:
606:
605:
603:
600:
599:
596:
595:Gene ontology
592:
588:
576:
571:
567:
562:
559:
557:
553:
545:
540:
529:
525:
521:
517:
513:
509:
505:
501:
497:
493:
492:
489:
485:
480:
477:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
430:
427:
423:
418:
415:
414:
411:
409:
405:
403:
402:
398:
397:
394:
392:
388:
384:
380:
376:
368:
363:
359:
355:
350:
340:
336:
329:
322:
316:
309:
301:
297:
293:
288:
284:
279:
275:
267:
262:
258:
254:
249:
239:
235:
228:
221:
215:
208:
204:
198:
194:
190:
185:
181:
176:
172:
168:
164:
160:
156:
152:
148:
144:
140:
136:
132:
124:
119:
112:
107:
102:
91:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
30:
19:
4335:Opsonization
4330:inflammation
4318:Cytotoxicity
4235:
4225:
4205:C1-inhibitor
4204:
4201:
4064:
4045:
3996:
3906:
3806:
3651:C1-inhibitor
3650:
3646:Antithrombin
3572:
3424:C1-inhibitor
3423:
3419:Berotralstat
3373:Fibrinolysin
3363:Chymotrypsin
3294:
3262:
3256:
3223:
3219:
3184:
3180:
3149:
3145:
3106:
3103:FEBS Letters
3102:
3068:(5): 477–9.
3065:
3061:
3019:(1): 265–8.
3016:
3012:
2963:
2959:
2910:
2906:
2880:(2): 301–8.
2877:
2873:
2841:(3): 755–9.
2838:
2834:
2800:(2): 231–2.
2797:
2793:
2758:
2754:
2715:
2712:FEBS Letters
2711:
2677:(5): 354–8.
2674:
2670:
2648:(4): 231–4.
2645:
2641:
2616:
2612:
2595:
2562:
2558:
2541:
2513:
2509:
2502:
2477:
2473:
2467:
2443:(1): 51–64.
2440:
2437:Glycobiology
2436:
2426:
2391:
2387:
2377:
2340:
2336:
2326:
2291:
2288:Nursing Open
2287:
2277:
2265:. Retrieved
2258:the original
2245:
2233:. Retrieved
2228:
2219:
2207:. Retrieved
2203:the original
2195:
2186:
2174:. Retrieved
2169:
2145:. Retrieved
2140:
2131:
2119:. Retrieved
2114:
2090:. Retrieved
2085:
2076:
2064:. Retrieved
2062:. 9 May 2018
2057:
2048:
2008:(1): 18577.
2005:
2001:
1991:
1956:
1952:
1942:
1917:
1913:
1907:
1885:(2): 301–8.
1882:
1878:
1872:
1842:(5): 477–9.
1839:
1835:
1829:
1796:
1792:
1758:
1754:
1748:
1734:cite journal
1697:
1693:
1683:
1674:
1665:
1656:
1647:
1592:
1576:
1566:
1558:
1555:
1550:
1548:
1445:1018837-94-9
1370:Legal status
1364:Legal status
1286:License data
1201:
1183:
1169:
1163:
1154:glycosylated
1149:
1133:
1131:
1109:
1105:
1102:C1-inhibitor
1101:
1100:
1023:
1005:NP_001027466
998:
972:
950:NM_001032295
947:
923:
904:
878:
859:
833:
814:
794:
789:
700:human ageing
690:fibrinolysis
502:carotid body
406:
399:
126:External IDs
85:
29:
3881:Transcortin
3555:PDB gallery
3444:Lanadelumab
3434:Ecallantide
2718:(1): 34–6.
2343:: 1727–37.
1583:orphan drug
1573:recombinant
1430:Identifiers
1323:Intravenous
1305:C1 esterase
1239:Other names
1230:Trade names
1218:C1 esterase
1212:Medical use
468:right ovary
365:84,605,788
352:84,595,731
264:57,619,171
251:57,597,387
104:Identifiers
4372:Categories
4195:Inhibitors
3624:inhibitory
3406:angioedema
3404:hereditary
2619:(1): 3–9.
2267:9 February
1700:(5): 216.
1642:, May 2017
1621:, May 2017
1597:References
1506:5QS67N4551
1499:6KIC4BB60G
1452:80295-38-1
1436:CAS Number
1190:bradykinin
1174:chromosome
1146:N-terminal
1142:C-terminal
1128:Proteomics
675:hemostasis
514:right lung
436:right lung
410:(ortholog)
344:2|2 D
147:HomoloGene
4328:Inducing
3907:see also
3876:Ovalbumin
3770:SERPINB13
3765:SERPINB10
3713:SERPINA14
3498:Voxelotor
3493:Mitapivat
3439:Icatibant
3358:Bromelain
3347:Enzymes (
2229:Drugs.com
2192:"Cinryze"
2176:30 August
2147:30 August
2121:30 August
1563:Synthesis
1316:Routes of
1268:Monograph
1261:Monograph
1252:Drugs.com
1026:NP_033906
1001:NP_000053
975:NM_009776
954:NM_000062
780:Orthologs
155:GeneCards
4362:Medicine
4320:(by MAC)
4311:Function
4239:Factor H
4219:Factor I
4073:Factor D
4068:Factor B
3957:Pathways
3822:SERPINI2
3817:SERPINI1
3812:SERPINH1
3807:SERPING1
3802:SERPINF1
3797:SERPINE2
3792:SERPINE2
3787:SERPINE1
3782:SERPIND1
3777:SERPINC1
3760:SERPINB9
3755:SERPINB8
3750:SERPINB7
3745:SERPINB6
3740:SERPINB5
3735:SERPINB4
3730:SERPINB3
3725:SERPINB2
3720:SERPINB1
3708:SERPINA9
3703:SERPINA5
3698:SERPINA4
3693:SERPINA3
3688:SERPINA2
3683:SERPINA1
3263:SERPING1
3257:SERPING1
3133:35981265
3090:21989261
2822:20492891
2742:28082291
2699:29076504
2633:15596403
2587:21223825
2522:10699156
2494:18220151
2459:14514717
2418:49269933
2410:29909591
2369:27660422
2318:30534402
2235:20 April
2209:20 April
2092:13 April
2066:13 April
2040:31819097
1983:18842294
1934:18220146
1864:21989261
1821:24583403
1813:16267649
1775:15514703
1726:16737556
1638:–
1617:–
1589:Research
1463:DrugBank
1330:ATC code
1300:DailyMed
1202:SERPING1
1170:SERPING1
1160:Genetics
1074:Wikidata
759:Sources:
498:gastrula
159:SERPING1
118:SERPING1
35:SERPING1
3617:Serpins
3393:Trypsin
3301:PDBe-KB
3291:UniProt
3276: (
3274:B02AB03
3240:3089875
3211:2723063
3168:2563376
3125:2365061
3082:2323781
3053:2296585
3021:Bibcode
3000:2154751
2968:Bibcode
2947:2118657
2915:Bibcode
2894:2026152
2865:1885769
2814:1684567
2785:1531292
2776:1130704
2734:1451784
2691:1363816
2662:1339401
2604:8172583
2579:7749926
2550:2478116
2360:5019432
2309:6279717
2031:6901466
2010:Bibcode
1974:5983350
1899:2026152
1856:2323781
1717:1779521
1640:Ensembl
1619:Ensembl
1551:Cinryze
1479:DB09228
1472:DB06404
1382::
1350: (
1348:B06AC04
1346:)
1340: (
1338:B06AC01
1302::
1112:) is a
892:UniProt
847:Ensembl
786:Species
765:QuickGO
506:decidua
385:pattern
243:11q12.1
111:Aliases
4348:Portal
4087:Middle
3871:Maspin
3845:SCCA-1
3507:Others
3296:P05155
3254:Human
3238:
3209:
3202:303909
3199:
3166:
3131:
3123:
3088:
3080:
3051:
3041:
2998:
2988:
2945:
2935:
2892:
2863:
2856:295456
2853:
2820:
2812:
2783:
2773:
2740:
2732:
2697:
2689:
2660:
2631:
2602:
2585:
2577:
2548:
2520:
2492:
2457:
2416:
2408:
2367:
2357:
2316:
2306:
2038:
2028:
1981:
1971:
1953:Lancet
1932:
1897:
1862:
1854:
1819:
1811:
1773:
1724:
1714:
1533:D10845
1526:D08780
1409:℞-only
1407:
1394:
1384:℞-only
1298:
1138:domain
1134:serpin
1118:serpin
1106:C1-inh
1060:search
1058:PubMed
925:P97290
906:P05155
802:Entrez
556:BioGPS
530:uterus
143:894696
135:606860
4281:CD11c
4277:CD11b
4053:MASP2
4049:MASP1
3990:Early
3514:Hemin
3464:B06AX
3410:B06AC
3349:B06AA
3129:S2CID
3086:S2CID
3044:53243
2991:53513
2938:54622
2818:S2CID
2738:S2CID
2695:S2CID
2583:S2CID
2414:S2CID
2261:(PDF)
2254:(PDF)
2196:U.S.
2141:(emc)
2115:(emc)
1860:S2CID
1817:S2CID
835:12258
795:Mouse
790:Human
761:Amigo
510:ankle
408:Mouse
401:Human
348:Start
283:Mouse
247:Start
180:Human
4285:CD18
4229:C4BP
4214:CD59
4202:CLA:
4148:Late
4108:iC3b
3896:PEDF
3850:CrmA
3840:MENT
3573:2oay
3458:and
3289:for
3236:PMID
3220:Gene
3207:PMID
3164:PMID
3121:PMID
3078:PMID
3049:PMID
2996:PMID
2943:PMID
2890:PMID
2861:PMID
2810:PMID
2781:PMID
2730:PMID
2687:PMID
2658:PMID
2629:PMID
2600:PMID
2575:PMID
2546:PMID
2518:PMID
2490:PMID
2455:PMID
2406:PMID
2365:PMID
2314:PMID
2269:2012
2237:2020
2211:2020
2178:2024
2149:2024
2123:2024
2094:2024
2068:2024
2036:PMID
1979:PMID
1930:PMID
1895:PMID
1852:PMID
1809:PMID
1771:PMID
1740:link
1722:PMID
1517:KEGG
1490:UNII
1248:AHFS
1166:gene
391:Bgee
339:Band
300:Chr.
238:Band
197:Chr.
131:OMIM
88:2OAY
69:RCSB
66:PDBe
4300:C5a
4295:C3a
4272:CR4
4267:CR3
4262:CR2
4257:CR1
4226:CL:
4160:C5b
4155:MAC
4125:C5b
4120:C5a
4104:C3b
4099:C3a
4058:MBL
4032:C4b
4027:C4a
4015:C1s
4010:C1r
4005:C1q
3339:B06
3287:PDB
3279:WHO
3228:doi
3197:PMC
3189:doi
3154:doi
3150:264
3111:doi
3107:266
3070:doi
3039:PMC
3029:doi
2986:PMC
2976:doi
2933:PMC
2923:doi
2882:doi
2878:197
2851:PMC
2843:doi
2802:doi
2771:PMC
2763:doi
2759:281
2720:doi
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