193:
40:
2658:
775:
Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP (April 2002). "Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex".
452:
core of CRLs consists of a RING protein and a cullin family member. For Cul1, the C-terminal cullin-homology domain binds the RING protein. The RING protein appears to function as a docking site for ubiquitin-conjugating
1789:
2042:
480:
subunit of the anaphase-promoting complex/cyclosome; both CUL9 and ANAPC2 have ubiquitin ligase activity. The N-terminal region of cullins is more variable, and is used to
272:
151:
1472:
662:
962:
1782:
1537:
1254:
1148:
1729:
1775:
2387:
1677:
829:"Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases"
2699:
436:
for ubiquitin-mediated destruction; as such, they are diverse in terms of composition and function, regulating many different processes from
99:
1643:
1194:
2605:
1465:
485:
955:
638:
516:, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase
1744:
1798:
1749:
1998:
1739:
1633:
1756:
1582:
292:
171:
1458:
2211:
948:
920:
2156:
1264:
481:
1602:
1577:
1562:
1522:
501:
2692:
1724:
1719:
1692:
1405:
1108:
407:
1638:
1597:
1557:
1547:
1542:
1527:
2718:
1714:
1653:
1624:
1507:
1498:
1103:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1607:
1532:
1517:
2096:
1489:
934:
539:
522:
1587:
1567:
1552:
1512:
526:(Baker's yeast), and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for
280:
159:
2421:
1055:
2593:
1612:
1592:
1572:
2723:
2462:
1704:
513:
24:
2685:
1843:
1734:
1387:
1138:
276:
155:
1662:
785:
112:
1806:
558:
2452:
1820:
1400:
1205:
858:
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551:
355:
320:
2122:
1395:
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267:
146:
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726:
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2296:
2286:
2086:
1667:
924:
889:
840:
793:
741:
689:
601:
591:
508:
recognises and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin
429:
312:
308:
2357:
2291:
930:
827:
Goldenberg SJ, Cascio TC, Shumway SD, Garbutt KC, Liu J, Xiong Y, Zheng N (November 2004).
259:
138:
2588:
1811:
517:
441:
417:
327:(CRLs) that are highly diverse and play a role in myriad cellular processes, most notably
789:
678:"cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family"
2135:
2130:
1709:
606:
579:
332:
694:
677:
2712:
1334:
531:
104:
761:
711:
221:
68:
2491:
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1356:
862:
813:
255:
134:
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1767:
233:
80:
2567:
2435:
1377:
1346:
543:
473:
346:
328:
845:
828:
2397:
1825:
1298:
1182:
971:
527:
505:
496:
With the exception of ANAPC2, each member of the cullin family is modified by
648:
2145:
2091:
1421:
1371:
1361:
1044:
1040:
1030:
1026:
1022:
1012:
1008:
998:
994:
469:
449:
414:
359:
316:
903:
894:
877:
854:
805:
753:
615:
703:
596:
192:
108:
39:
2640:
2626:
2425:
2058:
2050:
1426:
1366:
1351:
1320:
1306:
1036:
1018:
1004:
990:
547:
535:
228:
75:
580:"Cullin-RING ubiquitin ligases: Global regulation and activation cycles"
2665:
2176:
2063:
2023:
1954:
1949:
1944:
1939:
1934:
1889:
1435:
1342:
1315:
974:
509:
458:
437:
433:
92:
87:
20:
2657:
940:
197:
structure of the cul1-rbx1-skp1-f boxskp2 scf ubiquitin ligase complex
44:
structure of the cul1-rbx1-skp1-f boxskp2 scf ubiquitin ligase complex
2367:
2362:
2352:
2316:
2306:
2281:
2266:
2261:
2256:
2251:
2246:
2241:
2236:
2231:
2196:
2181:
2028:
1993:
1978:
1973:
1968:
1929:
1924:
1919:
1914:
1909:
1904:
1899:
1894:
1884:
1879:
1874:
1869:
1864:
1485:
1481:
1190:
1176:
1172:
1168:
1160:
1118:
1113:
982:
555:
477:
454:
403:
287:
166:
797:
745:
2583:
2573:
2563:
2548:
2530:
2525:
2520:
2515:
2447:
2407:
2372:
2346:
2331:
2326:
2321:
2276:
2271:
2226:
2221:
2216:
2186:
2171:
2068:
2037:
2018:
2013:
2008:
2003:
1988:
1983:
1963:
1859:
1852:
1848:
1838:
1833:
1682:
1249:
1244:
1133:
1128:
1123:
497:
380:
375:
676:
Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM (June 1996).
2636:
2622:
2598:
2578:
2558:
2553:
2503:
2486:
2442:
2430:
2412:
2402:
2201:
2191:
2166:
2161:
2106:
2101:
1697:
1687:
1278:
1269:
1239:
1218:
1156:
878:"Nedd8 on cullin: building an expressway to protein destruction"
462:
395:
390:
385:
369:
351:
342:
249:
216:
128:
63:
1771:
1454:
944:
432:(CRLs), such as Cul1 (SCF) play an essential role in targeting
1259:
1223:
1213:
1186:
1164:
466:
413:
CUL1, 2, 3, 4A, 4B, 5 and 7 each form part of a multi-subunit
727:"Function and regulation of cullin-RING ubiquitin ligases"
876:
Pan ZQ, Kentsis A, Dias DC, Yamoah K, Wu K (March 2004).
2673:
2635:
This article incorporates text from the public domain
2621:
This article incorporates text from the public domain
2541:
2472:
2461:
2144:
2121:
2079:
1819:
1805:
1652:
1623:
1497:
1414:
1386:
1333:
1297:
1288:
1232:
1204:
1147:
1054:
981:
286:
266:
248:
243:
227:
215:
207:
202:
185:
165:
145:
127:
122:
98:
86:
74:
62:
54:
49:
32:
2693:
1783:
1466:
956:
338:The human genome contains eight cullin genes
8:
578:Bosu, Dimple R.; Kipreos, Edward T. (2008).
402:There is also a more distant member called
2700:
2686:
2469:
1816:
1790:
1776:
1768:
1473:
1459:
1451:
1294:
963:
949:
941:
661:: CS1 maint: location missing publisher (
461:contain a cullin-homology domain, such as
319:appear to have cullins. They combine with
240:
191:
119:
38:
1255:Cellular apoptosis susceptibility protein
933:at the U.S. National Library of Medicine
893:
844:
725:Petroski MD, Deshaies RJ (January 2005).
693:
605:
595:
23:, a mountain range in Scotland, or with
570:
654:
182:
29:
1538:D-alanine—poly(phosphoribitol) ligase
550:conjugation of a Nedd8 moiety onto a
7:
2654:
2652:
2672:. You can help Knowledge (XXG) by
2606:Prokaryotic ubiquitin-like protein
1678:Von Hippel–Lindau tumor suppressor
14:
186:Cullin protein neddylation domain
2656:
1644:Long-chain-fatty-acid—CoA ligase
633:(Sixth ed.). New York, NY.
500:and several cullins function in
502:Ubiquitin-dependent proteolysis
2136:Mitochondrial targeting signal
1799:Posttranslational modification
1740:Carbamoyl phosphate synthetase
1634:Succinyl coenzyme A synthetase
1:
695:10.1016/S0092-8674(00)81267-2
631:Molecular biology of the cell
629:Bruce, Alberts (2014-11-18).
504:, a process in which the 26S
424:Cullin-RING ubiquitin ligases
325:Cullin-RING ubiquitin ligases
244:Available protein structures:
123:Available protein structures:
2212:Ubiquitin-conjugating enzyme
538:. The only identified Nedd8
307:are a family of hydrophobic
16:Hydrophobic scaffold protein
2500:E2 SUMO-conjugating enzyme
2157:Ubiquitin-activating enzyme
1265:Maturation promoting factor
2740:
2651:
2634:
2620:
2483:E1 SUMO-activating enzyme
1725:Holocarboxylase synthetase
1720:Argininosuccinate synthase
1693:Anaphase-promoting complex
1406:Postreplication checkpoint
846:10.1016/j.cell.2004.10.019
408:Anaphase-promoting complex
372:, part of CUL3-BTB complex
311:which provide support for
18:
1757:Glutamate–cysteine ligase
1715:Adenylosuccinate synthase
1508:Aminoacyl tRNA synthetase
239:
190:
118:
37:
2097:Survival of motor neuron
935:Medical Subject Headings
734:Nat. Rev. Mol. Cell Biol
523:Saccharomyces cerevisiae
512:. Nedd8/Rub1 is a small
19:Not to be confused with
2463:Ubiquitin-like proteins
2422:Deubiquitinating enzyme
444:to limb patterning and
406:(or APC2), part of the
2668:-related article is a
1705:Glutathione synthetase
1388:Cell cycle checkpoints
895:10.1038/sj.onc.1207414
514:ubiquitin-like protein
428:Cullin-RING ubiquitin
1735:Asparagine synthetase
1639:Acetyl—CoA synthetase
1415:Other cellular phases
1139:CDK-activating kinase
597:10.1186/1747-1028-3-7
492:Modification by NEDD8
1663:Glutamine synthetase
398:, also known as PARC
1821:Heat shock proteins
790:2002Natur.416..703Z
329:protein degradation
1401:Spindle checkpoint
1206:P53 p63 p73 family
2681:
2680:
2618:
2617:
2614:
2613:
2123:Protein targeting
2117:
2116:
1765:
1764:
1656:: Carbon-Nitrogen
1448:
1447:
1444:
1443:
1396:Restriction point
446:circadian rhythms
313:ubiquitin ligases
309:scaffold proteins
302:
301:
298:
297:
293:structure summary
181:
180:
177:
176:
172:structure summary
2731:
2719:Protein families
2702:
2695:
2688:
2660:
2653:
2470:
2383:Ubiquitin ligase
2149:(ubiquitylation)
2087:Alpha crystallin
1817:
1792:
1785:
1778:
1769:
1668:Ubiquitin ligase
1475:
1468:
1461:
1452:
1295:
965:
958:
951:
942:
925:Sanger Institute
908:
907:
897:
873:
867:
866:
848:
824:
818:
817:
772:
766:
765:
731:
722:
716:
715:
697:
673:
667:
666:
660:
652:
626:
620:
619:
609:
599:
575:
530:control and for
486:adaptor proteins
465:, also known as
241:
195:
183:
120:
42:
30:
2739:
2738:
2734:
2733:
2732:
2730:
2729:
2728:
2709:
2708:
2707:
2706:
2649:
2647:
2633:
2619:
2610:
2537:
2512:E3 SUMO ligase
2476:
2465:
2457:
2148:
2140:
2113:
2075:
2054:
2046:
1824:
1812:protein folding
1810:
1801:
1796:
1766:
1761:
1648:
1627:: Carbon-Sulfur
1619:
1501:: Carbon-Oxygen
1493:
1484:: CO CS and CN
1479:
1449:
1440:
1430:
1410:
1382:
1329:
1324:
1310:
1290:
1284:
1228:
1200:
1143:
1050:
977:
969:
931:Cullin+Proteins
917:
912:
911:
888:(11): 1985–97.
875:
874:
870:
826:
825:
821:
798:10.1038/416703a
784:(6882): 703–9.
774:
773:
769:
746:10.1038/nrm1547
729:
724:
723:
719:
675:
674:
670:
653:
641:
628:
627:
623:
577:
576:
572:
567:
494:
442:DNA replication
426:
198:
45:
28:
17:
12:
11:
5:
2737:
2735:
2727:
2726:
2721:
2711:
2710:
2705:
2704:
2697:
2690:
2682:
2679:
2678:
2661:
2616:
2615:
2612:
2611:
2609:
2608:
2602:
2601:
2596:
2591:
2586:
2581:
2576:
2571:
2561:
2556:
2551:
2545:
2543:
2539:
2538:
2536:
2535:
2534:
2533:
2528:
2523:
2518:
2509:
2508:
2507:
2506:
2497:
2496:
2495:
2494:
2489:
2480:
2478:
2467:
2459:
2458:
2456:
2455:
2450:
2445:
2439:
2438:
2433:
2428:
2418:
2417:
2416:
2415:
2410:
2405:
2400:
2395:
2390:
2378:
2377:
2376:
2375:
2370:
2365:
2360:
2355:
2350:
2344:
2339:
2334:
2329:
2324:
2319:
2314:
2309:
2304:
2299:
2294:
2289:
2284:
2279:
2274:
2269:
2264:
2259:
2254:
2249:
2244:
2239:
2234:
2229:
2224:
2219:
2207:
2206:
2205:
2204:
2199:
2194:
2189:
2184:
2179:
2174:
2169:
2164:
2152:
2150:
2142:
2141:
2139:
2138:
2133:
2131:Signal peptide
2127:
2125:
2119:
2118:
2115:
2114:
2112:
2111:
2110:
2109:
2104:
2094:
2089:
2083:
2081:
2077:
2076:
2074:
2073:
2072:
2071:
2066:
2061:
2056:
2052:
2048:
2044:
2034:
2033:
2032:
2031:
2026:
2021:
2016:
2011:
2006:
2001:
1996:
1991:
1986:
1981:
1976:
1971:
1960:
1959:
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1952:
1947:
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1937:
1932:
1927:
1922:
1917:
1912:
1907:
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1897:
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1882:
1877:
1872:
1867:
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1855:
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1814:
1803:
1802:
1797:
1795:
1794:
1787:
1780:
1772:
1763:
1762:
1760:
1759:
1754:
1753:
1752:
1747:
1737:
1732:
1727:
1722:
1717:
1712:
1710:CTP synthetase
1707:
1702:
1701:
1700:
1695:
1690:
1685:
1680:
1675:
1665:
1659:
1657:
1650:
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1641:
1636:
1630:
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1565:
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1535:
1530:
1525:
1520:
1515:
1504:
1502:
1495:
1494:
1480:
1478:
1477:
1470:
1463:
1455:
1446:
1445:
1442:
1441:
1439:
1438:
1433:
1428:
1424:
1418:
1416:
1412:
1411:
1409:
1408:
1403:
1398:
1392:
1390:
1384:
1383:
1381:
1380:
1375:
1369:
1364:
1359:
1354:
1349:
1339:
1337:
1331:
1330:
1328:
1327:
1322:
1318:
1313:
1308:
1303:
1301:
1292:
1286:
1285:
1283:
1282:
1272:
1267:
1262:
1257:
1252:
1247:
1242:
1236:
1234:
1230:
1229:
1227:
1226:
1221:
1216:
1210:
1208:
1202:
1201:
1199:
1198:
1180:
1153:
1151:
1145:
1144:
1142:
1141:
1136:
1131:
1126:
1121:
1116:
1111:
1106:
1101:
1096:
1091:
1086:
1081:
1076:
1071:
1066:
1060:
1058:
1052:
1051:
1049:
1048:
1034:
1016:
1002:
987:
985:
979:
978:
970:
968:
967:
960:
953:
945:
939:
938:
928:
916:
915:External links
913:
910:
909:
868:
819:
767:
717:
668:
639:
621:
569:
568:
566:
563:
493:
490:
484:with specific
425:
422:
400:
399:
393:
388:
383:
378:
373:
367:
349:
333:ubiquitination
300:
299:
296:
295:
290:
284:
283:
270:
264:
263:
253:
246:
245:
237:
236:
231:
225:
224:
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212:
209:
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149:
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125:
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102:
96:
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90:
84:
83:
78:
72:
71:
66:
60:
59:
56:
52:
51:
47:
46:
43:
35:
34:
15:
13:
10:
9:
6:
4:
3:
2:
2736:
2725:
2724:Protein stubs
2722:
2720:
2717:
2716:
2714:
2703:
2698:
2696:
2691:
2689:
2684:
2683:
2677:
2675:
2671:
2667:
2662:
2659:
2655:
2650:
2646:
2642:
2638:
2632:
2628:
2624:
2607:
2604:
2603:
2600:
2597:
2595:
2592:
2590:
2587:
2585:
2582:
2580:
2577:
2575:
2572:
2569:
2565:
2562:
2560:
2557:
2555:
2552:
2550:
2547:
2546:
2544:
2540:
2532:
2529:
2527:
2524:
2522:
2519:
2517:
2514:
2513:
2511:
2510:
2505:
2502:
2501:
2499:
2498:
2493:
2490:
2488:
2485:
2484:
2482:
2481:
2479:
2477:(SUMOylation)
2475:
2471:
2468:
2464:
2460:
2454:
2451:
2449:
2446:
2444:
2441:
2440:
2437:
2434:
2432:
2429:
2427:
2423:
2420:
2419:
2414:
2411:
2409:
2406:
2404:
2401:
2399:
2396:
2394:
2391:
2389:
2386:
2385:
2384:
2380:
2379:
2374:
2371:
2369:
2366:
2364:
2361:
2359:
2356:
2354:
2351:
2348:
2345:
2343:
2340:
2338:
2335:
2333:
2330:
2328:
2325:
2323:
2320:
2318:
2315:
2313:
2310:
2308:
2305:
2303:
2300:
2298:
2295:
2293:
2290:
2288:
2285:
2283:
2280:
2278:
2275:
2273:
2270:
2268:
2265:
2263:
2260:
2258:
2255:
2253:
2250:
2248:
2245:
2243:
2240:
2238:
2235:
2233:
2230:
2228:
2225:
2223:
2220:
2218:
2215:
2214:
2213:
2209:
2208:
2203:
2200:
2198:
2195:
2193:
2190:
2188:
2185:
2183:
2180:
2178:
2175:
2173:
2170:
2168:
2165:
2163:
2160:
2159:
2158:
2154:
2153:
2151:
2147:
2143:
2137:
2134:
2132:
2129:
2128:
2126:
2124:
2120:
2108:
2105:
2103:
2100:
2099:
2098:
2095:
2093:
2090:
2088:
2085:
2084:
2082:
2078:
2070:
2067:
2065:
2062:
2060:
2057:
2055:
2049:
2047:
2041:
2040:
2039:
2036:
2035:
2030:
2027:
2025:
2022:
2020:
2017:
2015:
2012:
2010:
2007:
2005:
2002:
2000:
1997:
1995:
1992:
1990:
1987:
1985:
1982:
1980:
1977:
1975:
1972:
1970:
1967:
1966:
1965:
1962:
1961:
1956:
1953:
1951:
1948:
1946:
1943:
1941:
1938:
1936:
1933:
1931:
1928:
1926:
1923:
1921:
1918:
1916:
1913:
1911:
1908:
1906:
1903:
1901:
1898:
1896:
1893:
1891:
1888:
1886:
1883:
1881:
1878:
1876:
1873:
1871:
1868:
1866:
1863:
1862:
1861:
1858:
1857:
1854:
1850:
1847:
1845:
1842:
1840:
1837:
1835:
1832:
1831:
1829:
1827:
1822:
1818:
1815:
1813:
1808:
1804:
1800:
1793:
1788:
1786:
1781:
1779:
1774:
1773:
1770:
1758:
1755:
1751:
1748:
1746:
1743:
1742:
1741:
1738:
1736:
1733:
1731:
1728:
1726:
1723:
1721:
1718:
1716:
1713:
1711:
1708:
1706:
1703:
1699:
1696:
1694:
1691:
1689:
1686:
1684:
1681:
1679:
1676:
1674:
1671:
1670:
1669:
1666:
1664:
1661:
1660:
1658:
1655:
1651:
1645:
1642:
1640:
1637:
1635:
1632:
1631:
1629:
1626:
1622:
1614:
1611:
1609:
1606:
1604:
1601:
1599:
1596:
1594:
1591:
1589:
1586:
1584:
1583:Phenylalanine
1581:
1579:
1576:
1574:
1571:
1569:
1566:
1564:
1561:
1559:
1556:
1554:
1551:
1549:
1546:
1544:
1541:
1539:
1536:
1534:
1531:
1529:
1526:
1524:
1521:
1519:
1516:
1514:
1511:
1510:
1509:
1506:
1505:
1503:
1500:
1496:
1491:
1487:
1483:
1476:
1471:
1469:
1464:
1462:
1457:
1456:
1453:
1437:
1434:
1432:
1425:
1423:
1420:
1419:
1417:
1413:
1407:
1404:
1402:
1399:
1397:
1394:
1393:
1391:
1389:
1385:
1379:
1376:
1373:
1370:
1368:
1365:
1363:
1360:
1358:
1355:
1353:
1350:
1348:
1344:
1341:
1340:
1338:
1336:
1332:
1326:
1319:
1317:
1314:
1312:
1305:
1304:
1302:
1300:
1296:
1293:
1287:
1280:
1276:
1273:
1271:
1268:
1266:
1263:
1261:
1258:
1256:
1253:
1251:
1248:
1246:
1243:
1241:
1238:
1237:
1235:
1231:
1225:
1222:
1220:
1217:
1215:
1212:
1211:
1209:
1207:
1203:
1196:
1192:
1188:
1184:
1181:
1178:
1174:
1170:
1166:
1162:
1158:
1155:
1154:
1152:
1150:
1149:CDK inhibitor
1146:
1140:
1137:
1135:
1132:
1130:
1127:
1125:
1122:
1120:
1117:
1115:
1112:
1110:
1107:
1105:
1102:
1100:
1097:
1095:
1092:
1090:
1087:
1085:
1082:
1080:
1077:
1075:
1072:
1070:
1067:
1065:
1062:
1061:
1059:
1057:
1053:
1046:
1042:
1038:
1035:
1032:
1028:
1024:
1020:
1017:
1014:
1010:
1006:
1003:
1000:
996:
992:
989:
988:
986:
984:
980:
976:
973:
966:
961:
959:
954:
952:
947:
946:
943:
936:
932:
929:
926:
922:
921:Cullin family
919:
918:
914:
905:
901:
896:
891:
887:
883:
879:
872:
869:
864:
860:
856:
852:
847:
842:
839:(4): 517–28.
838:
834:
830:
823:
820:
815:
811:
807:
803:
799:
795:
791:
787:
783:
779:
771:
768:
763:
759:
755:
751:
747:
743:
739:
735:
728:
721:
718:
713:
709:
705:
701:
696:
691:
688:(6): 829–39.
687:
683:
679:
672:
669:
664:
658:
650:
646:
642:
640:9780815344322
636:
632:
625:
622:
617:
613:
608:
603:
598:
593:
589:
585:
584:Cell Division
581:
574:
571:
564:
562:
560:
557:
553:
549:
545:
542:are cullins.
541:
537:
533:
532:embryogenesis
529:
525:
524:
519:
515:
511:
507:
503:
499:
491:
489:
487:
483:
479:
475:
471:
468:
464:
460:
457:(E2s). Other
456:
451:
447:
443:
439:
435:
431:
423:
421:
419:
416:
411:
409:
405:
397:
394:
392:
389:
387:
384:
382:
379:
377:
374:
371:
368:
365:
361:
357:
353:
350:
348:
344:
341:
340:
339:
336:
334:
330:
326:
322:
321:RING proteins
318:
314:
310:
306:
294:
291:
289:
285:
282:
278:
274:
271:
269:
265:
261:
257:
254:
251:
247:
242:
238:
235:
232:
230:
226:
223:
220:
218:
214:
210:
206:
201:
194:
189:
184:
173:
170:
168:
164:
161:
157:
153:
150:
148:
144:
140:
136:
133:
130:
126:
121:
117:
114:
110:
106:
103:
101:
97:
94:
91:
89:
85:
82:
79:
77:
73:
70:
67:
65:
61:
57:
53:
48:
41:
36:
31:
26:
22:
2674:expanding it
2663:
2648:
2474:SUMO protein
2392:
1730:GMP synthase
1672:
1357:Prometaphase
1274:
885:
881:
871:
836:
832:
822:
781:
777:
770:
737:
733:
720:
685:
681:
671:
630:
624:
587:
583:
573:
521:
495:
440:sensing and
427:
412:
401:
337:
324:
304:
303:
211:Cullin_Nedd8
2568:neddylation
1834:Hsp10/GroES
1826:Chaperonins
1378:Cytokinesis
1347:Preprophase
1291:checkpoints
740:(1): 9–20.
546:results in
544:Neddylation
470:cytoplasmic
356:ECS complex
347:SCF complex
203:Identifiers
50:Identifiers
2713:Categories
1860:Hsp40/DnaJ
1807:Chaperones
1603:Tryptophan
1578:Methionine
1563:Isoleucine
1523:Asparagine
1299:Interphase
1289:Phases and
972:Cell cycle
565:References
540:substrates
528:cell cycle
506:proteasome
476:, and the
354:, part of
345:, part of
317:eukaryotes
315:(E3). All
256:structures
135:structures
2645:IPR019559
2631:IPR001373
2146:Ubiquitin
2092:Clusterin
1598:Threonine
1558:Histidine
1548:Glutamine
1543:Glutamate
1528:Aspartate
1422:Apoptosis
1372:Telophase
1362:Metaphase
1157:INK4a/ARF
657:cite book
649:887605755
552:conserved
536:metazoans
450:catalytic
415:ubiquitin
362:- CUL2 -
360:Elongin C
234:IPR019559
93:PDOC00967
81:IPR001373
2641:InterPro
2627:InterPro
2426:Ataxin 3
1608:Tyrosine
1533:Cysteine
1518:Arginine
1492:6.1-6.3)
1367:Anaphase
1352:Prophase
975:proteins
927:website.
904:15021886
882:Oncogene
855:15537541
806:11961546
762:24159190
754:15688063
712:15805562
616:18282298
548:covalent
482:interact
459:proteins
434:proteins
364:SOCS-box
323:to form
273:RCSB PDB
229:InterPro
152:RCSB PDB
76:InterPro
2666:protein
2349:(CDC34)
1588:Proline
1568:Leucine
1553:Glycine
1513:Alanine
1486:ligases
1482:Enzymes
1436:Meiosis
1343:Mitosis
1335:M phase
1316:S phase
1183:cip/kip
863:1606360
814:4423882
786:Bibcode
704:8681378
607:2266742
559:residue
554:cullin
518:complex
472:anchor
455:enzymes
438:glucose
430:ligases
418:complex
305:Cullins
222:PF10557
88:PROSITE
69:PF00888
21:Cuillin
2393:Cullin
1673:Cullin
1613:Valine
1593:Serine
1573:Lysine
1275:Cullin
1161:p14arf
983:Cyclin
937:(MeSH)
902:
861:
853:
812:
804:
778:Nature
760:
752:
710:
702:
647:
637:
614:
604:
556:lysine
510:chains
478:ANAPC2
448:. The
404:ANAPC2
288:PDBsum
262:
252:
208:Symbol
167:PDBsum
141:
131:
113:SUPFAM
58:Cullin
55:Symbol
33:Cullin
2664:This
2584:ATG12
2574:FAT10
2564:NEDD8
2549:ISG15
2542:Other
2531:PIAS4
2526:PIAS3
2521:PIAS2
2516:PIAS1
2466:(UBL)
2448:BIRC6
2408:FANCL
2080:Other
2069:TRAP1
2038:Hsp90
1964:Hsp70
1853:GroEL
1849:HSP60
1844:Hsp47
1839:Hsp27
1683:UBE3A
1431:phase
1325:phase
1311:phase
1250:Cdc42
1245:Cdc25
1233:Other
1015:, B3)
859:S2CID
810:S2CID
758:S2CID
730:(PDF)
708:S2CID
590:: 7.
498:Nedd8
381:CUL4B
376:CUL4A
109:SCOPe
100:SCOP2
25:Culin
2670:stub
2639:and
2637:Pfam
2625:and
2623:Pfam
2599:UBL5
2589:FUB1
2579:ATG8
2559:UFM1
2554:URM1
2504:UBC9
2492:SAE2
2487:SAE1
2453:UFC1
2443:ATG3
2436:CYLD
2431:USP6
2413:UBR1
2403:MDM2
2202:SAE1
2197:NAE1
2192:ATG7
2187:UBA7
2182:UBA6
2177:UBA5
2172:UBA3
2167:UBA2
2162:UBA1
2107:SMN2
2102:SMN1
1698:UBR1
1688:Mdm2
1279:CUL7
1240:Cdc2
900:PMID
851:PMID
833:Cell
802:PMID
750:PMID
700:PMID
682:Cell
663:link
645:OCLC
635:ISBN
612:PMID
474:PARC
463:CUL9
396:CUL9
391:CUL7
386:CUL5
370:CUL3
352:CUL2
343:CUL1
281:PDBj
277:PDBe
260:ECOD
250:Pfam
217:Pfam
160:PDBj
156:PDBe
139:ECOD
129:Pfam
105:1ldj
64:Pfam
2594:MUB
2398:CBL
2388:VHL
2381:E3
2210:E2
2155:E1
2024:12A
1955:C19
1950:C14
1945:C13
1940:C11
1935:C10
1890:B11
1654:6.3
1625:6.2
1499:6.1
1270:Wee
1260:E2F
1224:p73
1219:p63
1214:p53
1195:p57
1191:p27
1187:p21
1177:p19
1173:p18
1169:p15
1165:p16
1119:11B
1114:11A
1056:CDK
890:doi
841:doi
837:119
794:doi
782:416
742:doi
690:doi
602:PMC
592:doi
534:in
520:in
467:p53
331:by
268:PDB
147:PDB
2715::
2643::
2629::
2424::
2368:V2
2363:V1
2353:R2
2347:R1
2342:Q2
2337:Q1
2317:L6
2312:L4
2307:L3
2302:L2
2297:L1
2287:J2
2282:J1
2267:G2
2262:G1
2257:E3
2252:E2
2247:E1
2242:D3
2237:D2
2232:D1
2064:ER
2029:14
1994:4L
1979:1L
1974:1B
1969:1A
1930:C7
1925:C6
1920:C5
1915:C3
1910:C1
1905:B9
1900:B6
1895:B4
1885:B2
1880:B1
1875:A3
1870:A2
1865:A1
1750:II
1490:EC
1193:,
1189:,
1175:,
1171:,
1167:,
1134:14
1129:13
1124:12
1109:10
1045:E2
1043:,
1041:E1
1031:D3
1029:,
1027:D2
1025:,
1023:D1
1013:B2
1011:,
1009:B1
999:A2
997:,
995:A1
923:-
898:.
886:23
884:.
880:.
857:.
849:.
835:.
831:.
808:.
800:.
792:.
780:.
756:.
748:.
736:.
732:.
706:.
698:.
686:85
684:.
680:.
659:}}
655:{{
643:.
610:.
600:.
586:.
582:.
561:.
488:.
420:.
410:.
335:.
279:;
275:;
258:/
158:;
154:;
137:/
111:/
107:/
2701:e
2694:t
2687:v
2676:.
2570:)
2566:(
2373:Z
2358:S
2332:O
2327:N
2322:M
2292:K
2277:I
2272:H
2227:C
2222:B
2217:A
2059:β
2053:2
2051:α
2045:1
2043:α
2019:9
2014:8
2009:7
2004:6
1999:5
1989:4
1984:2
1851:/
1823:/
1809:/
1791:e
1784:t
1777:v
1745:I
1488:(
1474:e
1467:t
1460:v
1429:0
1427:G
1374:)
1345:(
1323:2
1321:G
1309:1
1307:G
1281:)
1277:(
1197:)
1185:(
1179:)
1163:/
1159:(
1104:9
1099:8
1094:7
1089:6
1084:5
1079:4
1074:3
1069:2
1064:1
1047:)
1039:(
1037:E
1033:)
1021:(
1019:D
1007:(
1005:B
1001:)
993:(
991:A
964:e
957:t
950:v
906:.
892::
865:.
843::
816:.
796::
788::
764:.
744::
738:6
714:.
692::
665:)
651:.
618:.
594::
588:3
366:)
358:(
27:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
