1322:
were generally found in ER-positive breast cancer. Together, these findings indicate that CDK7 therapy might make sense for some breast cancer patients. Further confirming these findings, recent research indicates that inhibition of CDK7 may be an effective therapy for HER2-positive breast cancers, even overcoming therapeutic resistance. THZ1 was tested on HER2-positive breast cancer cells and exhibited high potency for the cells regardless of their sensitivity to HER2 inhibitors. This finding was demonstrated in vivo, where inhibition of HER2 and CDK7 resulted in tumor regression in therapeutically resistant HER2+ xenograft models.
304:
281:
178:
203:
555:
310:
209:
31:
3188:
5875:
1341:
similar structures in the region surrounding C312. It was found that treatment of 250 nM THZ1 was sufficient to inhibit global transcription and that cancer cell lines were sensitive to much lower concentrations, opening up further research into the efficacy of using THZ1 as a component of cancer therapy, as described above.
1330:
The growth suppressor p53 has been shown to interact with cyclin H both in vitro and in vivo. Addition of wild type p53 was found to heavily downregulated CAK activity, resulting in decreased phosphorylation of both CDK2 and CTD by CDK7. Mutant p53 was unable to downregulate CDK7 activity and mutant
1321:
Given that CDK7 is involved in two important regulation roles, it's expected that CDK7 regulation may play a role in cancerous cells. Cells from breast cancer tumors were found to have elevated levels of CDK7 and Cyclin H when compared to normal breast cells. It was also found that the higher levels
1351:
Based on molecular docking results, Ligands-3, 5, 14, and 16 were screened among 17 different
Pyrrolone-fused benzosuberene compounds as potent and specific inhibitors without any cross-reactivity against different CDK isoforms. Analysis of MD simulations and MM-PBSA studies, revealed the binding
1340:
is an inhibitor for CDK7 that selectively forms a covalent bond with the CDK7-cycH-MAT1 complex. This selectivity stems from forming a bond at C312, which is unique to CDK7 within the CDK family. CDK12 and CDK13 could also be inhibited using THZ1 (but at higher concentrations) because they have
1348:(RCC), the expression of CDK7 was significantly higher in the advanced stage tumors. Besides, the overall survival was significantly shorter in patients with higher CDK7 expression in the tumors. These results suggest that CDK7 may be a potential target for overcoming RCC.
57:
1352:
energy profiles of all the selected complexes. Selected ligands performed better than the experimental drug candidate (Roscovitine). Ligands-3 and 14 show specificity for CDK7. These ligands are expected to possess lower risk of side effects due to their natural origin.
2698:
Levedakou EN, He M, Baptist EW, Craven RJ, Cance WG, Welcsh PL, et al. (July 1994). "Two novel human serine/threonine kinases with homologies to the cell cycle regulating
Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern".
1355:
In urothelial carcinoma (UC), CDK7 expression is increased in bladder cancer tissues, especially in patients with chemoresistance. CDK7 inhibition-related cancer stemness suppression is a potential therapeutic strategy for both chemonaïve and chemoresistant UC.
2602:
Darbon JM, Devault A, Taviaux S, Fesquet D, Martinez AM, Galas S, et al. (November 1994). "Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase".
1727:
1886:
Chow PM, Chang YW, Kuo KL, Lin WC, Liu SH, Huang KH (June 2021). "CDK7 Inhibition by THZ1 Suppresses Cancer
Stemness in both Chemonaïve and Chemoresistant Urothelial Carcinoma via the Hedgehog Signaling Pathway".
3738:
4023:
1799:
Chow PM, Liu SH, Chang YW, Kuo KL, Lin WC, Huang KH (February 2020). "The covalent CDK7 inhibitor THZ1 enhances temsirolimus-induced cytotoxicity via autophagy suppression in human renal cell carcinoma".
2741:
Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (December 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor".
1986:
Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (December 1995). "Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor".
2434:
Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, et al. (March 1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH".
2168:
Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, et al. (March 1995). "Cdk-activating kinase complex is a component of human transcription factor TFIIH".
3731:
2720:
Wu L, Yee A, Liu L, Carbonaro-Hall D, Venkatesan N, Tolo VT, Hall FL (July 1994). "Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase".
1940:"From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator"
1313:, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.
2624:
Williams RT, Wu L, Carbonaro-Hall DA, Hall FL (October 1994). "Identification, assay, and purification of a Cdc2-activating threonine-161 protein kinase from human cells".
3724:
3931:
1843:
Singh R, Bhardwaj VK, Das P, Purohit R (November 2019). "Natural analogues inhibiting selective cyclin-dependent kinase protein isoforms: a computational perspective".
317:
216:
2514:
Serizawa H, Mäkelä TP, Conaway JW, Conaway RC, Weinberg RA, Young RA (March 1995). "Association of Cdk-activating kinase subunits with transcription factor TFIIH".
3228:
4479:
5318:
3782:
2221:"MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions"
2999:
Parada CA, Roeder RG (November 1996). "Enhanced processivity of RNA polymerase II triggered by Tat-induced phosphorylation of its carboxy-terminal domain".
5427:
2481:"Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase"
4165:
4052:
928:
4440:
909:
139:
3520:
3414:
5413:
4878:
3769:
3751:
5515:
5396:
5102:
3971:
2653:
Mäkelä TP, Tassan JP, Nigg EA, Frutiger S, Hughes GJ, Weinberg RA (September 1994). "A cyclin associated with the CDK-activating kinase MO15".
2013:
Mäkelä TP, Tassan JP, Nigg EA, Frutiger S, Hughes GJ, Weinberg RA (September 1994). "A cyclin associated with the CDK-activating kinase MO15".
5166:
4141:
3167:
1507:
1489:
5895:
5422:
3460:
303:
3956:
2823:
2806:
1203:
5479:
5154:
3100:
1196:
280:
5594:
4411:
4401:
4086:
3221:
2069:"CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA"
1584:"Expression of CDK7, Cyclin H, and MAT1 Is Elevated in Breast Cancer and Is Prognostic in Estrogen Receptor-Positive Breast Cancer"
5093:
1568:
5362:
5034:
4396:
4387:
1476:
1455:
2561:"Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)"
5750:
1472:
202:
177:
54:
4777:
4274:
4265:
3922:
3868:
3112:
1451:
5865:
3965:
3214:
3187:
119:
3530:
1365:
2850:"Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH"
3716:
316:
215:
4989:
4807:
4303:
3671:
3374:
2807:"Expression of CDK7/CAK in normal and tumor cells of diverse histogenesis, cell-cycle position and differentiation"
5735:
1525:
Fisher RP, Morgan DO (August 1994). "A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase".
5851:
5838:
5825:
5812:
5799:
5786:
5773:
4979:
4969:
4959:
4954:
4949:
4939:
4734:
4509:
4105:
3369:
3364:
3354:
3349:
3344:
3339:
3334:
3329:
3160:
2954:
Zhou Q, Sharp PA (October 1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat".
1288:
309:
208:
5745:
1633:"Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers"
5699:
5642:
5202:
5193:
5144:
3910:
3755:
3094:
1281:
977:
127:
1309:, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor
5647:
5502:
4925:
3321:
1423:
1277:
958:
954:
1295:
1331:
p21 had no effect on downregulation, indicating that p53 is responsible for negative regulation of CDK7.
5668:
5587:
4201:
3653:
3404:
5740:
2311:"A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A"
4768:
3153:
3008:
2963:
2914:
2861:
2662:
2523:
2443:
2396:
2177:
2022:
1755:
1345:
191:
106:
5900:
5704:
3118:
3106:
1569:"Entrez Gene: CDK7 cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)"
1154:
1150:
1146:
1136:
1132:
1128:
1124:
1120:
1079:
1075:
1071:
1067:
1057:
1053:
1049:
1045:
110:, CAK1, CDKN7, HCAK, MO15, STK1, p39MO15, CAK, cyclin-dependent kinase 7, cyclin dependent kinase 7
5276:
5910:
5637:
5379:
5333:
3666:
3471:
3090:
3032:
2987:
2836:
2686:
2547:
2467:
2422:
2201:
2121:"Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH"
2046:
1920:
1868:
1825:
1710:
1550:
151:
1685:
Schneider E, Montenarh M, Wagner P (November 1998). "Regulation of CAK kinase activity by p53".
1179:
1158:
1100:
1041:
5905:
4639:
4348:
3661:
3125:
3071:
3024:
2979:
2942:
2889:
2828:
2793:
2750:
2729:
2708:
2678:
2641:
2612:
2590:
2539:
2502:
2459:
2414:
2371:
2332:
2309:
Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, et al. (July 2004).
2291:
2242:
2219:
Talukder AH, Mishra SK, Mandal M, Balasenthil S, Mehta S, Sahin AA, et al. (March 2003).
2193:
2150:
2098:
2038:
1995:
1961:
1912:
1904:
1860:
1817:
1781:
1702:
1664:
1613:
1582:
Patel H, Abduljabbar R, Lai CF, Periyasamy M, Harrod A, Gemma C, et al. (December 2016).
1542:
1373:
99:
47:
5683:
5678:
5652:
5580:
5232:
4474:
4464:
4459:
4377:
4368:
4298:
4289:
4235:
4226:
3883:
3061:
3016:
2971:
2932:
2922:
2879:
2869:
2818:
2783:
2775:
2670:
2633:
2580:
2572:
2531:
2492:
2451:
2404:
2363:
2322:
2281:
2273:
2232:
2185:
2140:
2132:
2088:
2080:
2030:
1951:
1896:
1852:
1809:
1771:
1763:
1694:
1654:
1644:
1603:
1595:
1534:
554:
396:
327:
271:
226:
5730:
5714:
5627:
5058:
4129:
4124:
4119:
371:
147:
3050:"Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes"
3012:
2967:
2918:
2865:
2666:
2527:
2447:
2400:
2181:
2067:
Garber ME, Mayall TP, Suess EM, Meisenhelder J, Thompson NE, Jones KA (September 2000).
2026:
1759:
5879:
5768:
5709:
3045:
2585:
2560:
2145:
2120:
1776:
1743:
1659:
1632:
1608:
1583:
2788:
2763:
2409:
2384:
2286:
2261:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
702:
697:
692:
687:
682:
677:
672:
656:
651:
646:
641:
636:
631:
626:
621:
616:
611:
606:
601:
596:
30:
5889:
5673:
5632:
4182:
4114:
3600:
3134:
2937:
2902:
2884:
2849:
2093:
2084:
2068:
1924:
1872:
1829:
1538:
583:
2991:
2903:"Human cyclin-dependent kinase-activating kinase exists in three distinct complexes"
2426:
2260:
Ko LJ, Shieh SY, Chen X, Jayaraman L, Tamai K, Taya Y, et al. (December 1997).
5622:
5053:
3878:
3622:
3036:
2840:
2690:
2551:
2471:
2205:
2050:
1729:...first patient dosed in phase 1 clinical trial of its oral CDK7 inhibitor: CT7001
1714:
1554:
1428:
389:
168:
131:
1856:
1631:
Sun B, Mason S, Wilson RC, Hazard SE, Wang Y, Fang R, et al. (January 2020).
1599:
2975:
1900:
1813:
155:
5846:
5781:
5617:
5259:
4891:
4831:
4714:
4634:
4358:
3643:
3612:
1512:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1494:
National Center for
Biotechnology Information, U.S. National Library of Medicine
5874:
2907:
Proceedings of the
National Academy of Sciences of the United States of America
2854:
Proceedings of the
National Academy of Sciences of the United States of America
472:
5347:
3821:
3564:
3448:
3237:
2136:
1649:
288:
185:
135:
2497:
2480:
1908:
1744:"Targeting transcription regulation in cancer with a covalent CDK7 inhibitor"
5820:
5794:
4308:
3687:
3637:
3627:
3310:
3306:
3296:
3292:
3288:
3278:
3274:
3264:
3260:
3066:
3049:
2927:
2874:
1956:
1939:
1452:
ENSG00000277273 GRCh38: Ensembl release 89: ENSG00000134058, ENSG00000277273
1280:(CDK) family. CDK family members are highly similar to the gene products of
873:
532:
410:
355:
342:
254:
241:
143:
2762:
Blau J, Xiao H, McCracken S, O'Hare P, Greenblatt J, Bentley D (May 1996).
2637:
2336:
2277:
2246:
2237:
2220:
2102:
1965:
1916:
1821:
1785:
1698:
1668:
1617:
3075:
3028:
2983:
2946:
2893:
2832:
2824:
10.1002/(SICI)1097-0215(19960611)66:6<732::AID-IJC4>3.0.CO;2-0
2797:
2779:
2754:
2733:
2712:
2682:
2645:
2616:
2594:
2576:
2543:
2506:
2463:
2418:
2375:
2295:
2197:
2154:
2042:
1999:
1864:
1706:
1546:
1334:
In 2017 CT7001, an oral CDK7 inhibitor, started a phase 1 clinical trial.
1243:
1238:
4664:
4559:
4554:
4549:
3692:
3632:
3617:
3586:
3572:
3302:
3284:
3270:
3256:
1379:
1302:
1227:
1022:
1003:
1767:
5323:
5301:
5296:
5286:
5281:
5083:
5078:
5073:
5068:
5063:
5048:
5043:
4694:
4659:
3898:
3893:
3888:
3701:
3608:
3581:
3240:
3139:
3129:
2385:"Transcriptional control: Tat cofactors and transcriptional elongation"
2367:
989:
940:
729:
regulation of cyclin-dependent protein serine/threonine kinase activity
3206:
2262:"p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner"
76:
5833:
5603:
5553:
5548:
5543:
5538:
5533:
5528:
5523:
5474:
5469:
5464:
5459:
5454:
5437:
5432:
5306:
5291:
5242:
5237:
5222:
5217:
5212:
5207:
5181:
5176:
5171:
5159:
5137:
5132:
5024:
4999:
4674:
4499:
4494:
4489:
4484:
4469:
4313:
4250:
4245:
4240:
4216:
4042:
4037:
4011:
4006:
4001:
3991:
3986:
3976:
3816:
3747:
3540:
3456:
3442:
3438:
3434:
3426:
3384:
3379:
3248:
3020:
2674:
2535:
2455:
2189:
2034:
1403:
1385:
1263:
1211:
895:
2848:
Reardon JT, Ge H, Gibbs E, Sancar A, Hurwitz J, Pan ZQ (June 1996).
693:
cyclin-dependent protein kinase activating kinase holoenzyme complex
2901:
Drapkin R, Le Roy G, Cho H, Akoulitchev S, Reinberg D (June 1996).
2327:
2310:
5807:
5449:
5442:
5352:
5249:
5149:
5127:
5122:
5117:
5112:
5107:
5019:
5014:
5009:
5004:
4994:
4964:
4944:
4821:
4816:
4797:
4792:
4782:
4758:
4753:
4748:
4724:
4719:
4709:
4704:
4699:
4689:
4669:
4654:
4649:
4644:
4624:
4619:
4609:
4604:
4599:
4594:
4589:
4579:
4574:
4569:
4564:
4544:
4539:
4534:
4529:
4524:
4519:
4504:
4454:
4449:
4343:
4338:
4333:
4328:
4323:
4318:
4279:
4211:
4206:
4155:
4150:
4076:
4071:
4066:
4032:
4024:
3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring) kinase
3826:
3811:
3806:
3801:
3796:
3791:
3515:
3510:
3399:
3394:
3389:
2354:
Jeang KT (1998). "Tat, Tat-associated kinase, and transcription".
1391:
1310:
1284:
858:
854:
5342:
5269:
5264:
5254:
5227:
4984:
4934:
4915:
4910:
4905:
4900:
4855:
4850:
4845:
4840:
4787:
4743:
4684:
4679:
4629:
4614:
4584:
4514:
4430:
4425:
4420:
4353:
4255:
4196:
4191:
4095:
4061:
3946:
3941:
3936:
3905:
3873:
3861:
3856:
3851:
3841:
3836:
3544:
3535:
3505:
3484:
3422:
1337:
1306:
1291:
1270:
123:
5576:
5500:
4876:
3767:
3720:
3210:
3149:
2764:"Three functional classes of transcriptional activation domain"
563:
5311:
3846:
3831:
3525:
3489:
3479:
3452:
3430:
3145:
1409:
1397:
3124:
Overview of all the structural information available in the
5572:
2559:
Tassan JP, Schultz SJ, Bartek J, Nigg EA (October 1994).
809:
positive regulation of transcription by RNA polymerase II
657:
cyclin-dependent protein serine/threonine kinase activity
637:
RNA polymerase II CTD heptapeptide repeat kinase activity
819:
nucleotide-excision repair, preincision complex assembly
799:
transcription initiation from RNA polymerase II promoter
749:
transcription elongation from RNA polymerase II promoter
379:
844:
transcription elongation from RNA polymerase I promoter
744:
transcription initiation from RNA polymerase I promoter
5863:
544:
1276:
The protein encoded by this gene is a member of the
5759:
5723:
5692:
5661:
5610:
5514:
5412:
5395:
5378:
5361:
5332:
5192:
5092:
5033:
4924:
4890:
4830:
4806:
4767:
4733:
4439:
4410:
4386:
4367:
4288:
4264:
4225:
4181:
4164:
4140:
4104:
4085:
4051:
4022:
3955:
3921:
3781:
3680:
3652:
3599:
3563:
3554:
3498:
3470:
3413:
3320:
3247:
2119:Rossignol M, Kolb-Cheynel I, Egly JM (April 1997).
1172:
1119:
1093:
1040:
779:
positive regulation of transcription, DNA-templated
1468:
1466:
1464:
1447:
1445:
1443:
326:
225:
794:transcription-coupled nucleotide-excision repair
2062:
2060:
16:Protein-coding gene in the species Homo sapiens
2805:Bartkova J, Zemanova M, Bartek J (June 1996).
2114:
2112:
1981:
1979:
1977:
1975:
1845:Journal of Biomolecular Structure and Dynamics
1473:GRCm38: Ensembl release 89: ENSMUSG00000069089
1294:, and are known to be important regulators of
5588:
3783:Non-specific serine/threonine protein kinases
3732:
3222:
3161:
2479:Aprelikova O, Xiong Y, Liu ET (August 1995).
1680:
1678:
719:termination of RNA polymerase I transcription
8:
1364:Cyclin-dependent kinase 7 has been shown to
1301:This protein forms a trimeric complex with
5595:
5581:
5573:
5511:
5497:
4887:
4873:
4166:Goodpasture-antigen-binding protein kinase
3778:
3764:
3739:
3725:
3717:
3560:
3229:
3215:
3207:
3168:
3154:
3146:
1116:
1037:
869:
734:regulation of transcription, DNA-templated
579:
367:
266:
163:
65:
4879:Serine/threonine-specific protein kinases
4053:(isocitrate dehydrogenase (NADP+)) kinase
3770:Serine/threonine-specific protein kinases
3752:Serine/threonine-specific protein kinases
3521:Cellular apoptosis susceptibility protein
3093:at the U.S. National Library of Medicine
3065:
2936:
2926:
2883:
2873:
2822:
2787:
2584:
2496:
2408:
2326:
2285:
2236:
2144:
2092:
1955:
1775:
1658:
1648:
1607:
5414:Receptor protein serine/threonine kinase
814:snRNA transcription by RNA polymerase II
769:cellular response to DNA damage stimulus
652:protein serine/threonine kinase activity
5870:
5397:Low-density-lipoprotein receptor kinase
3183:
2626:Archives of Biochemistry and Biophysics
1938:Lee DK, Duan HO, Chang C (March 2000).
1439:
698:transcription factor TFIIH holo complex
20:
4142:Fas-activated serine/threonine kinase
839:G2/M transition of mitotic cell cycle
834:G1/S transition of mitotic cell cycle
612:ATP-dependent activity, acting on DNA
331:
292:
287:
230:
189:
184:
7:
5423:Bone morphogenetic protein receptors
3957:Dephospho-(reductase kinase) kinase
3138:(Cyclin-dependent kinase 7) at the
3054:The Journal of Biological Chemistry
2485:The Journal of Biological Chemistry
2383:Yankulov K, Bentley D (June 1998).
2225:The Journal of Biological Chemistry
1944:The Journal of Biological Chemistry
1742:Kwiatkowski N, et al. (2014).
724:androgen receptor signaling pathway
519:migratory enteric neural crest cell
4412:G-protein coupled receptor kinases
1169:
1090:
1013:
994:
968:
945:
919:
900:
759:transcription by RNA polymerase II
703:transcription factor TFIIK complex
617:transcription coactivator activity
549:
467:
405:
384:
14:
4402:Beta adrenergic receptor kinase-2
4087:(tyrosine 3-monooxygenase) kinase
3196:: Crystal Structure of Human CDK7
1317:Clinical significance e.g. cancer
1266:that in humans is encoded by the
5873:
5094:Mitogen-activated protein kinase
3186:
2085:10.1128/mcb.20.18.6958-6969.2000
553:
315:
308:
302:
279:
214:
207:
201:
176:
29:
5480:Anti-Müllerian hormone receptor
5363:(acetyl-CoA carboxylase) kinase
5035:(RNA-polymerase)-subunit kinase
4397:Beta adrenergic receptor kinase
4388:Beta adrenergic receptor kinase
2811:International Journal of Cancer
1278:cyclin-dependent protein kinase
678:perinuclear region of cytoplasm
5103:Extracellular signal-regulated
3044:García-Martínez LF, Ivanov D,
2768:Molecular and Cellular Biology
2266:Molecular and Cellular Biology
2073:Molecular and Cellular Biology
1260:cell division protein kinase 7
754:7-methylguanosine mRNA capping
564:More reference expression data
533:More reference expression data
441:olfactory zone of nasal mucosa
1:
5167:P38 mitogen-activated protein
4266:cGMP-dependent protein kinase
4227:cAMP-dependent protein kinase
3923:Pyruvate dehydrogenase kinase
3869:Ataxia telangiectasia mutated
2410:10.1016/S0960-9822(98)70289-1
2356:Journal of Biomedical Science
1857:10.1080/07391102.2019.1696709
1600:10.1158/1078-0432.CCR-15-1104
804:cell population proliferation
300:
199:
3966:AMP-activated protein kinase
2976:10.1126/science.274.5287.605
1901:10.1016/j.canlet.2021.03.012
1814:10.1016/j.canlet.2019.12.005
1539:10.1016/0092-8674(94)90535-5
764:transcription, DNA-templated
5896:Genes on human chromosome 5
4881:(EC 2.7.11.21-EC 2.7.11.30)
3531:Maturation promoting factor
3105:human gene location in the
2565:The Journal of Cell Biology
449:stromal cell of endometrium
5927:
4808:Elongation factor 2 kinase
3772:(EC 2.7.11.1-EC 2.7.11.20)
3672:Postreplication checkpoint
3117:human gene details in the
1204:Chr 13: 100.84 – 100.87 Mb
622:protein C-terminus binding
5751:Michaelis–Menten kinetics
5510:
5496:
5203:MAP kinase kinase kinases
4886:
4872:
4735:Myosin light-chain kinase
4441:Ca2+/calmodulin-dependent
4106:Myosin-heavy-chain kinase
3777:
3763:
3181:
1650:10.1038/s41388-019-0953-9
1508:"Mouse PubMed Reference:"
1490:"Human PubMed Reference:"
1289:Schizosaccharomyces pombe
1256:Cyclin-dependent kinase 7
1242:
1237:
1233:
1226:
1210:
1191:
1176:
1143:
1112:
1097:
1064:
1033:
1020:
1016:
1001:
997:
988:
975:
971:
952:
948:
939:
926:
922:
907:
903:
894:
879:
872:
868:
852:
632:androgen receptor binding
582:
578:
561:
552:
543:
530:
479:
470:
417:
408:
378:
370:
366:
349:
336:
299:
278:
269:
265:
248:
235:
198:
175:
166:
162:
117:
114:
104:
97:
92:
73:
68:
51:
46:
41:
37:
28:
23:
5643:Diffusion-limited enzyme
5503:Dual-specificity kinases
3095:Medical Subject Headings
2498:10.1074/jbc.270.31.18195
1588:Clinical Cancer Research
1282:Saccharomyces cerevisiae
4926:Cyclin-dependent kinase
3067:10.1074/jbc.272.11.6951
2928:10.1073/pnas.93.13.6488
2875:10.1073/pnas.93.13.6482
2137:10.1093/emboj/16.7.1628
1957:10.1074/jbc.275.13.9308
1424:Cyclin-dependent kinase
1197:Chr 5: 69.23 – 69.28 Mb
784:protein phosphorylation
602:protein kinase activity
3654:Cell cycle checkpoints
2638:10.1006/abbi.1994.1416
2278:10.1128/mcb.17.12.7220
2238:10.1074/jbc.M209570200
1699:10.1038/sj.onc.1202504
1296:cell cycle progression
333:13 D1|13 53.23 cM
5736:Eadie–Hofstee diagram
5669:Allosteric regulation
3681:Other cellular phases
3405:CDK-activating kinase
2780:10.1128/MCB.16.5.2044
2577:10.1083/jcb.127.2.467
829:protein stabilization
294:Chromosome 13 (mouse)
5746:Lineweaver–Burk plot
4769:Phosphorylase kinase
1346:renal cell carcinoma
597:transferase activity
192:Chromosome 5 (human)
69:List of PDB id codes
42:Available structures
3119:UCSC Genome Browser
3107:UCSC Genome Browser
3091:CDK7+protein,+human
3013:1996Natur.384..375P
2968:1996Sci...274..605Z
2919:1996PNAS...93.6488D
2866:1996PNAS...93.6482R
2667:1994Natur.371..254M
2528:1995Natur.374..280S
2448:1995Natur.374..283S
2401:1998CBio....8.R447Y
2182:1995Natur.374..283S
2027:1994Natur.371..254M
1768:10.1038/nature13393
1760:2014Natur.511..616K
503:endocardial cushion
429:islet of Langerhans
5705:Enzyme superfamily
5638:Enzyme promiscuity
5380:Tropomyosin kinase
5334:Tau-protein kinase
3667:Spindle checkpoint
3472:P53 p63 p73 family
2368:10.1007/BF02253352
978:ENSMUSG00000069089
712:Biological process
666:Cellular component
607:nucleotide binding
590:Molecular function
5861:
5860:
5570:
5569:
5566:
5565:
5562:
5561:
5492:
5491:
5488:
5487:
4868:
4867:
4864:
4863:
4349:Protein kinase N1
4304:Protein kinase Cζ
3714:
3713:
3710:
3709:
3662:Restriction point
3204:
3203:
1851:(17): 5126–5135.
1594:(23): 5929–5938.
1374:Androgen receptor
1253:
1252:
1249:
1248:
1222:
1221:
1187:
1186:
1166:
1165:
1108:
1107:
1087:
1086:
1029:
1028:
1010:
1009:
984:
983:
965:
964:
935:
934:
916:
915:
864:
863:
574:
573:
570:
569:
539:
538:
526:
525:
464:
463:
362:
361:
261:
260:
88:
87:
84:
83:
52:Ortholog search:
5918:
5878:
5877:
5869:
5741:Hanes–Woolf plot
5684:Enzyme activator
5679:Enzyme inhibitor
5653:Enzyme catalysis
5597:
5590:
5583:
5574:
5512:
5498:
5145:C-Jun N-terminal
4888:
4874:
4378:Rhodopsin kinase
4369:Rhodopsin kinase
4299:Protein kinase C
4290:Protein kinase C
4275:Protein kinase G
4236:Protein kinase A
3847:Protein kinase B
3779:
3765:
3741:
3734:
3727:
3718:
3561:
3231:
3224:
3217:
3208:
3190:
3170:
3163:
3156:
3147:
3079:
3069:
3040:
3021:10.1038/384375a0
2995:
2962:(5287): 605–10.
2950:
2940:
2930:
2897:
2887:
2877:
2844:
2826:
2801:
2791:
2758:
2737:
2716:
2694:
2675:10.1038/371254a0
2649:
2620:
2598:
2588:
2555:
2536:10.1038/374280a0
2510:
2500:
2475:
2456:10.1038/374283a0
2430:
2412:
2379:
2341:
2340:
2330:
2306:
2300:
2299:
2289:
2257:
2251:
2250:
2240:
2231:(13): 11676–85.
2216:
2210:
2209:
2190:10.1038/374283a0
2165:
2159:
2158:
2148:
2125:The EMBO Journal
2116:
2107:
2106:
2096:
2064:
2055:
2054:
2035:10.1038/371254a0
2010:
2004:
2003:
1983:
1970:
1969:
1959:
1935:
1929:
1928:
1883:
1877:
1876:
1840:
1834:
1833:
1796:
1790:
1789:
1779:
1754:(7511): 616–20.
1739:
1733:
1725:
1719:
1718:
1682:
1673:
1672:
1662:
1652:
1628:
1622:
1621:
1611:
1579:
1573:
1572:
1565:
1559:
1558:
1522:
1516:
1515:
1504:
1498:
1497:
1486:
1480:
1470:
1459:
1449:
1235:
1234:
1206:
1199:
1182:
1170:
1161:
1117:
1113:RefSeq (protein)
1103:
1091:
1082:
1038:
1014:
995:
969:
946:
920:
901:
870:
580:
566:
557:
550:
535:
487:primitive streak
475:
473:Top expressed in
468:
413:
411:Top expressed in
406:
385:
368:
358:
345:
334:
319:
312:
306:
295:
283:
267:
257:
244:
233:
218:
211:
205:
194:
180:
164:
158:
156:CDK7 - orthologs
109:
102:
79:
66:
60:
39:
38:
33:
21:
5926:
5925:
5921:
5920:
5919:
5917:
5916:
5915:
5886:
5885:
5884:
5872:
5864:
5862:
5857:
5769:Oxidoreductases
5755:
5731:Enzyme kinetics
5719:
5715:List of enzymes
5688:
5657:
5628:Catalytic triad
5606:
5601:
5571:
5558:
5506:
5484:
5408:
5391:
5374:
5357:
5328:
5188:
5088:
5059:P70-S6 Kinase 1
5029:
4920:
4882:
4860:
4826:
4802:
4763:
4729:
4435:
4406:
4382:
4363:
4284:
4260:
4221:
4177:
4160:
4136:
4130:Aurora C kinase
4125:Aurora B kinase
4120:Aurora A kinase
4100:
4081:
4047:
4018:
3951:
3917:
3773:
3759:
3745:
3715:
3706:
3696:
3676:
3648:
3595:
3590:
3576:
3556:
3550:
3494:
3466:
3409:
3316:
3243:
3235:
3205:
3200:
3197:
3191:
3177:
3174:
3087:
3082:
3043:
3007:(6607): 375–8.
2998:
2953:
2913:(13): 6488–93.
2900:
2847:
2804:
2761:
2749:(24): 6058–62.
2743:Cancer Research
2740:
2719:
2697:
2661:(6494): 254–7.
2652:
2623:
2611:(11): 3127–38.
2601:
2558:
2522:(6519): 280–2.
2513:
2491:(31): 18195–7.
2478:
2442:(6519): 283–7.
2433:
2389:Current Biology
2382:
2353:
2349:
2347:Further reading
2344:
2315:Nature Genetics
2308:
2307:
2303:
2259:
2258:
2254:
2218:
2217:
2213:
2176:(6519): 283–7.
2167:
2166:
2162:
2118:
2117:
2110:
2079:(18): 6958–69.
2066:
2065:
2058:
2021:(6494): 254–7.
2012:
2011:
2007:
1994:(24): 6058–62.
1988:Cancer Research
1985:
1984:
1973:
1950:(13): 9308–13.
1937:
1936:
1932:
1885:
1884:
1880:
1842:
1841:
1837:
1798:
1797:
1793:
1741:
1740:
1736:
1726:
1722:
1693:(21): 2733–41.
1684:
1683:
1676:
1630:
1629:
1625:
1581:
1580:
1576:
1567:
1566:
1562:
1524:
1523:
1519:
1506:
1505:
1501:
1488:
1487:
1483:
1471:
1462:
1450:
1441:
1437:
1420:
1415:
1362:
1328:
1319:
1244:View/Edit Mouse
1239:View/Edit Human
1202:
1195:
1192:Location (UCSC)
1178:
1157:
1153:
1149:
1145:
1139:
1135:
1131:
1127:
1123:
1099:
1078:
1074:
1070:
1066:
1060:
1056:
1052:
1048:
1044:
959:ENSG00000277273
957:
955:ENSG00000134058
848:
739:phosphorylation
707:
661:
647:kinase activity
627:protein binding
562:
531:
522:
517:
513:
509:
505:
501:
497:
495:renal corpuscle
493:
489:
485:
471:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
353:
340:
332:
322:
321:
320:
313:
293:
270:Gene location (
252:
239:
231:
221:
220:
219:
212:
190:
167:Gene location (
118:
105:
98:
75:
53:
17:
12:
11:
5:
5924:
5922:
5914:
5913:
5908:
5903:
5898:
5888:
5887:
5883:
5882:
5859:
5858:
5856:
5855:
5842:
5829:
5816:
5803:
5790:
5777:
5763:
5761:
5757:
5756:
5754:
5753:
5748:
5743:
5738:
5733:
5727:
5725:
5721:
5720:
5718:
5717:
5712:
5707:
5702:
5696:
5694:
5693:Classification
5690:
5689:
5687:
5686:
5681:
5676:
5671:
5665:
5663:
5659:
5658:
5656:
5655:
5650:
5645:
5640:
5635:
5630:
5625:
5620:
5614:
5612:
5608:
5607:
5602:
5600:
5599:
5592:
5585:
5577:
5568:
5567:
5564:
5563:
5560:
5559:
5557:
5556:
5551:
5546:
5541:
5536:
5531:
5526:
5520:
5518:
5508:
5507:
5501:
5494:
5493:
5490:
5489:
5486:
5485:
5483:
5482:
5477:
5472:
5467:
5462:
5457:
5452:
5447:
5446:
5445:
5440:
5435:
5430:
5419:
5417:
5416:(EC 2.7.11.30)
5410:
5409:
5407:
5406:
5402:
5400:
5399:(EC 2.7.11.29)
5393:
5392:
5390:
5389:
5385:
5383:
5382:(EC 2.7.11.28)
5376:
5375:
5373:
5372:
5368:
5366:
5365:(EC 2.7.11.27)
5359:
5358:
5356:
5355:
5350:
5345:
5339:
5337:
5336:(EC 2.7.11.26)
5330:
5329:
5327:
5326:
5321:
5316:
5315:
5314:
5309:
5304:
5299:
5294:
5289:
5284:
5274:
5273:
5272:
5267:
5262:
5257:
5247:
5246:
5245:
5240:
5235:
5230:
5225:
5220:
5215:
5210:
5199:
5197:
5196:(EC 2.7.11.25)
5190:
5189:
5187:
5186:
5185:
5184:
5179:
5174:
5164:
5163:
5162:
5157:
5152:
5142:
5141:
5140:
5135:
5130:
5125:
5120:
5115:
5110:
5099:
5097:
5096:(EC 2.7.11.24)
5090:
5089:
5087:
5086:
5081:
5076:
5071:
5066:
5061:
5056:
5051:
5046:
5040:
5038:
5037:(EC 2.7.11.23)
5031:
5030:
5028:
5027:
5022:
5017:
5012:
5007:
5002:
4997:
4992:
4987:
4982:
4977:
4972:
4967:
4962:
4957:
4952:
4947:
4942:
4937:
4931:
4929:
4928:(EC 2.7.11.22)
4922:
4921:
4919:
4918:
4913:
4908:
4903:
4897:
4895:
4894:(EC 2.7.11.21)
4884:
4883:
4877:
4870:
4869:
4866:
4865:
4862:
4861:
4859:
4858:
4853:
4848:
4843:
4837:
4835:
4834:(EC 2.7.11.21)
4828:
4827:
4825:
4824:
4819:
4813:
4811:
4810:(EC 2.7.11.20)
4804:
4803:
4801:
4800:
4795:
4790:
4785:
4780:
4774:
4772:
4771:(EC 2.7.11.19)
4765:
4764:
4762:
4761:
4756:
4751:
4746:
4740:
4738:
4737:(EC 2.7.11.18)
4731:
4730:
4728:
4727:
4722:
4717:
4712:
4707:
4702:
4697:
4692:
4687:
4682:
4677:
4672:
4667:
4662:
4657:
4652:
4647:
4642:
4637:
4632:
4627:
4622:
4617:
4612:
4607:
4602:
4597:
4592:
4587:
4582:
4577:
4572:
4567:
4562:
4557:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4507:
4502:
4497:
4492:
4487:
4482:
4477:
4472:
4467:
4462:
4457:
4452:
4446:
4444:
4443:(EC 2.7.11.17)
4437:
4436:
4434:
4433:
4428:
4423:
4417:
4415:
4414:(EC 2.7.11.16)
4408:
4407:
4405:
4404:
4399:
4393:
4391:
4390:(EC 2.7.11.15)
4384:
4383:
4381:
4380:
4374:
4372:
4371:(EC 2.7.11.14)
4365:
4364:
4362:
4361:
4356:
4351:
4346:
4341:
4336:
4331:
4326:
4321:
4316:
4311:
4306:
4301:
4295:
4293:
4292:(EC 2.7.11.13)
4286:
4285:
4283:
4282:
4277:
4271:
4269:
4268:(EC 2.7.11.12)
4262:
4261:
4259:
4258:
4253:
4248:
4243:
4238:
4232:
4230:
4229:(EC 2.7.11.11)
4223:
4222:
4220:
4219:
4214:
4209:
4204:
4199:
4194:
4188:
4186:
4185:(EC 2.7.11.10)
4179:
4178:
4176:
4175:
4171:
4169:
4162:
4161:
4159:
4158:
4153:
4147:
4145:
4138:
4137:
4135:
4134:
4133:
4132:
4127:
4122:
4111:
4109:
4102:
4101:
4099:
4098:
4092:
4090:
4083:
4082:
4080:
4079:
4074:
4069:
4064:
4058:
4056:
4049:
4048:
4046:
4045:
4040:
4035:
4029:
4027:
4020:
4019:
4017:
4016:
4015:
4014:
4009:
4004:
3996:
3995:
3994:
3989:
3981:
3980:
3979:
3974:
3962:
3960:
3953:
3952:
3950:
3949:
3944:
3939:
3934:
3928:
3926:
3919:
3918:
3916:
3915:
3914:
3913:
3903:
3902:
3901:
3896:
3891:
3886:
3876:
3871:
3866:
3865:
3864:
3859:
3854:
3844:
3839:
3834:
3829:
3824:
3819:
3814:
3809:
3804:
3799:
3794:
3788:
3786:
3775:
3774:
3768:
3761:
3760:
3746:
3744:
3743:
3736:
3729:
3721:
3712:
3711:
3708:
3707:
3705:
3704:
3699:
3694:
3690:
3684:
3682:
3678:
3677:
3675:
3674:
3669:
3664:
3658:
3656:
3650:
3649:
3647:
3646:
3641:
3635:
3630:
3625:
3620:
3615:
3605:
3603:
3597:
3596:
3594:
3593:
3588:
3584:
3579:
3574:
3569:
3567:
3558:
3552:
3551:
3549:
3548:
3538:
3533:
3528:
3523:
3518:
3513:
3508:
3502:
3500:
3496:
3495:
3493:
3492:
3487:
3482:
3476:
3474:
3468:
3467:
3465:
3464:
3446:
3419:
3417:
3411:
3410:
3408:
3407:
3402:
3397:
3392:
3387:
3382:
3377:
3372:
3367:
3362:
3357:
3352:
3347:
3342:
3337:
3332:
3326:
3324:
3318:
3317:
3315:
3314:
3300:
3282:
3268:
3253:
3251:
3245:
3244:
3236:
3234:
3233:
3226:
3219:
3211:
3202:
3201:
3199:
3198:
3192:
3185:
3182:
3179:
3178:
3175:
3173:
3172:
3165:
3158:
3150:
3144:
3143:
3122:
3110:
3098:
3086:
3085:External links
3083:
3081:
3080:
3060:(11): 6951–8.
3048:(March 1997).
3041:
2996:
2951:
2898:
2860:(13): 6482–7.
2845:
2802:
2774:(5): 2044–55.
2759:
2738:
2728:(7): 2089–96.
2717:
2707:(7): 1977–88.
2695:
2650:
2621:
2599:
2556:
2511:
2476:
2431:
2395:(13): R447-9.
2380:
2350:
2348:
2345:
2343:
2342:
2328:10.1038/ng1387
2301:
2272:(12): 7220–9.
2252:
2211:
2160:
2131:(7): 1628–37.
2108:
2056:
2005:
1971:
1930:
1889:Cancer Letters
1878:
1835:
1802:Cancer Letters
1791:
1734:
1720:
1674:
1623:
1574:
1560:
1517:
1499:
1481:
1460:
1438:
1436:
1433:
1432:
1431:
1426:
1419:
1416:
1414:
1413:
1407:
1401:
1395:
1389:
1383:
1377:
1370:
1361:
1358:
1327:
1324:
1318:
1315:
1251:
1250:
1247:
1246:
1241:
1231:
1230:
1224:
1223:
1220:
1219:
1217:
1215:
1208:
1207:
1200:
1193:
1189:
1188:
1185:
1184:
1174:
1173:
1167:
1164:
1163:
1141:
1140:
1114:
1110:
1109:
1106:
1105:
1095:
1094:
1088:
1085:
1084:
1062:
1061:
1035:
1031:
1030:
1027:
1026:
1018:
1017:
1011:
1008:
1007:
999:
998:
992:
986:
985:
982:
981:
973:
972:
966:
963:
962:
950:
949:
943:
937:
936:
933:
932:
924:
923:
917:
914:
913:
905:
904:
898:
892:
891:
886:
881:
877:
876:
866:
865:
862:
861:
850:
849:
847:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
715:
713:
709:
708:
706:
705:
700:
695:
690:
685:
680:
675:
669:
667:
663:
662:
660:
659:
654:
649:
644:
639:
634:
629:
624:
619:
614:
609:
604:
599:
593:
591:
587:
586:
576:
575:
572:
571:
568:
567:
559:
558:
547:
541:
540:
537:
536:
528:
527:
524:
523:
521:
520:
516:
512:
508:
504:
500:
496:
492:
491:abdominal wall
488:
484:
480:
477:
476:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
402:
401:
393:
382:
376:
375:
372:RNA expression
364:
363:
360:
359:
351:
347:
346:
338:
335:
330:
324:
323:
314:
307:
301:
297:
296:
291:
285:
284:
276:
275:
263:
262:
259:
258:
250:
246:
245:
237:
234:
229:
223:
222:
213:
206:
200:
196:
195:
188:
182:
181:
173:
172:
160:
159:
116:
112:
111:
103:
95:
94:
90:
89:
86:
85:
82:
81:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
5923:
5912:
5909:
5907:
5904:
5902:
5899:
5897:
5894:
5893:
5891:
5881:
5876:
5871:
5867:
5853:
5849:
5848:
5843:
5840:
5836:
5835:
5830:
5827:
5823:
5822:
5817:
5814:
5810:
5809:
5804:
5801:
5797:
5796:
5791:
5788:
5784:
5783:
5778:
5775:
5771:
5770:
5765:
5764:
5762:
5758:
5752:
5749:
5747:
5744:
5742:
5739:
5737:
5734:
5732:
5729:
5728:
5726:
5722:
5716:
5713:
5711:
5710:Enzyme family
5708:
5706:
5703:
5701:
5698:
5697:
5695:
5691:
5685:
5682:
5680:
5677:
5675:
5674:Cooperativity
5672:
5670:
5667:
5666:
5664:
5660:
5654:
5651:
5649:
5646:
5644:
5641:
5639:
5636:
5634:
5633:Oxyanion hole
5631:
5629:
5626:
5624:
5621:
5619:
5616:
5615:
5613:
5609:
5605:
5598:
5593:
5591:
5586:
5584:
5579:
5578:
5575:
5555:
5552:
5550:
5547:
5545:
5542:
5540:
5537:
5535:
5532:
5530:
5527:
5525:
5522:
5521:
5519:
5517:
5513:
5509:
5504:
5499:
5495:
5481:
5478:
5476:
5473:
5471:
5468:
5466:
5463:
5461:
5458:
5456:
5453:
5451:
5448:
5444:
5441:
5439:
5436:
5434:
5431:
5429:
5426:
5425:
5424:
5421:
5420:
5418:
5415:
5411:
5404:
5403:
5401:
5398:
5394:
5387:
5386:
5384:
5381:
5377:
5370:
5369:
5367:
5364:
5360:
5354:
5351:
5349:
5346:
5344:
5341:
5340:
5338:
5335:
5331:
5325:
5322:
5320:
5317:
5313:
5310:
5308:
5305:
5303:
5300:
5298:
5295:
5293:
5290:
5288:
5285:
5283:
5280:
5279:
5278:
5275:
5271:
5268:
5266:
5263:
5261:
5258:
5256:
5253:
5252:
5251:
5248:
5244:
5241:
5239:
5236:
5234:
5231:
5229:
5226:
5224:
5221:
5219:
5216:
5214:
5211:
5209:
5206:
5205:
5204:
5201:
5200:
5198:
5195:
5191:
5183:
5180:
5178:
5175:
5173:
5170:
5169:
5168:
5165:
5161:
5158:
5156:
5153:
5151:
5148:
5147:
5146:
5143:
5139:
5136:
5134:
5131:
5129:
5126:
5124:
5121:
5119:
5116:
5114:
5111:
5109:
5106:
5105:
5104:
5101:
5100:
5098:
5095:
5091:
5085:
5082:
5080:
5077:
5075:
5072:
5070:
5067:
5065:
5062:
5060:
5057:
5055:
5052:
5050:
5047:
5045:
5042:
5041:
5039:
5036:
5032:
5026:
5023:
5021:
5018:
5016:
5013:
5011:
5008:
5006:
5003:
5001:
4998:
4996:
4993:
4991:
4988:
4986:
4983:
4981:
4978:
4976:
4973:
4971:
4968:
4966:
4963:
4961:
4958:
4956:
4953:
4951:
4948:
4946:
4943:
4941:
4938:
4936:
4933:
4932:
4930:
4927:
4923:
4917:
4914:
4912:
4909:
4907:
4904:
4902:
4899:
4898:
4896:
4893:
4889:
4885:
4880:
4875:
4871:
4857:
4854:
4852:
4849:
4847:
4844:
4842:
4839:
4838:
4836:
4833:
4829:
4823:
4820:
4818:
4815:
4814:
4812:
4809:
4805:
4799:
4796:
4794:
4791:
4789:
4786:
4784:
4781:
4779:
4776:
4775:
4773:
4770:
4766:
4760:
4757:
4755:
4752:
4750:
4747:
4745:
4742:
4741:
4739:
4736:
4732:
4726:
4723:
4721:
4718:
4716:
4713:
4711:
4708:
4706:
4703:
4701:
4698:
4696:
4693:
4691:
4688:
4686:
4683:
4681:
4678:
4676:
4673:
4671:
4668:
4666:
4663:
4661:
4658:
4656:
4653:
4651:
4648:
4646:
4643:
4641:
4638:
4636:
4633:
4631:
4628:
4626:
4623:
4621:
4618:
4616:
4613:
4611:
4608:
4606:
4603:
4601:
4598:
4596:
4593:
4591:
4588:
4586:
4583:
4581:
4578:
4576:
4573:
4571:
4568:
4566:
4563:
4561:
4558:
4556:
4553:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4513:
4511:
4508:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4481:
4478:
4476:
4473:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4447:
4445:
4442:
4438:
4432:
4429:
4427:
4424:
4422:
4419:
4418:
4416:
4413:
4409:
4403:
4400:
4398:
4395:
4394:
4392:
4389:
4385:
4379:
4376:
4375:
4373:
4370:
4366:
4360:
4357:
4355:
4352:
4350:
4347:
4345:
4342:
4340:
4337:
4335:
4332:
4330:
4327:
4325:
4322:
4320:
4317:
4315:
4312:
4310:
4307:
4305:
4302:
4300:
4297:
4296:
4294:
4291:
4287:
4281:
4278:
4276:
4273:
4272:
4270:
4267:
4263:
4257:
4254:
4252:
4249:
4247:
4244:
4242:
4239:
4237:
4234:
4233:
4231:
4228:
4224:
4218:
4215:
4213:
4210:
4208:
4205:
4203:
4200:
4198:
4195:
4193:
4190:
4189:
4187:
4184:
4180:
4173:
4172:
4170:
4168:(EC 2.7.11.9)
4167:
4163:
4157:
4154:
4152:
4149:
4148:
4146:
4144:(EC 2.7.11.8)
4143:
4139:
4131:
4128:
4126:
4123:
4121:
4118:
4117:
4116:
4115:Aurora kinase
4113:
4112:
4110:
4108:(EC 2.7.11.7)
4107:
4103:
4097:
4094:
4093:
4091:
4089:(EC 2.7.11.6)
4088:
4084:
4078:
4075:
4073:
4070:
4068:
4065:
4063:
4060:
4059:
4057:
4055:(EC 2.7.11.5)
4054:
4050:
4044:
4041:
4039:
4036:
4034:
4031:
4030:
4028:
4026:(EC 2.7.11.4)
4025:
4021:
4013:
4010:
4008:
4005:
4003:
4000:
3999:
3997:
3993:
3990:
3988:
3985:
3984:
3982:
3978:
3975:
3973:
3970:
3969:
3967:
3964:
3963:
3961:
3959:(EC 2.7.11.3)
3958:
3954:
3948:
3945:
3943:
3940:
3938:
3935:
3933:
3930:
3929:
3927:
3925:(EC 2.7.11.2)
3924:
3920:
3912:
3909:
3908:
3907:
3904:
3900:
3897:
3895:
3892:
3890:
3887:
3885:
3882:
3881:
3880:
3879:EIF-2 kinases
3877:
3875:
3872:
3870:
3867:
3863:
3860:
3858:
3855:
3853:
3850:
3849:
3848:
3845:
3843:
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3818:
3815:
3813:
3810:
3808:
3805:
3803:
3800:
3798:
3795:
3793:
3790:
3789:
3787:
3785:(EC 2.7.11.1)
3784:
3780:
3776:
3771:
3766:
3762:
3757:
3753:
3749:
3742:
3737:
3735:
3730:
3728:
3723:
3722:
3719:
3703:
3700:
3698:
3691:
3689:
3686:
3685:
3683:
3679:
3673:
3670:
3668:
3665:
3663:
3660:
3659:
3657:
3655:
3651:
3645:
3642:
3639:
3636:
3634:
3631:
3629:
3626:
3624:
3621:
3619:
3616:
3614:
3610:
3607:
3606:
3604:
3602:
3598:
3592:
3585:
3583:
3580:
3578:
3571:
3570:
3568:
3566:
3562:
3559:
3553:
3546:
3542:
3539:
3537:
3534:
3532:
3529:
3527:
3524:
3522:
3519:
3517:
3514:
3512:
3509:
3507:
3504:
3503:
3501:
3497:
3491:
3488:
3486:
3483:
3481:
3478:
3477:
3475:
3473:
3469:
3462:
3458:
3454:
3450:
3447:
3444:
3440:
3436:
3432:
3428:
3424:
3421:
3420:
3418:
3416:
3415:CDK inhibitor
3412:
3406:
3403:
3401:
3398:
3396:
3393:
3391:
3388:
3386:
3383:
3381:
3378:
3376:
3373:
3371:
3368:
3366:
3363:
3361:
3358:
3356:
3353:
3351:
3348:
3346:
3343:
3341:
3338:
3336:
3333:
3331:
3328:
3327:
3325:
3323:
3319:
3312:
3308:
3304:
3301:
3298:
3294:
3290:
3286:
3283:
3280:
3276:
3272:
3269:
3266:
3262:
3258:
3255:
3254:
3252:
3250:
3246:
3242:
3239:
3232:
3227:
3225:
3220:
3218:
3213:
3212:
3209:
3195:
3189:
3184:
3180:
3171:
3166:
3164:
3159:
3157:
3152:
3151:
3148:
3141:
3137:
3136:
3131:
3127:
3123:
3120:
3116:
3115:
3111:
3108:
3104:
3103:
3099:
3096:
3092:
3089:
3088:
3084:
3077:
3073:
3068:
3063:
3059:
3055:
3051:
3047:
3042:
3038:
3034:
3030:
3026:
3022:
3018:
3014:
3010:
3006:
3002:
2997:
2993:
2989:
2985:
2981:
2977:
2973:
2969:
2965:
2961:
2957:
2952:
2948:
2944:
2939:
2934:
2929:
2924:
2920:
2916:
2912:
2908:
2904:
2899:
2895:
2891:
2886:
2881:
2876:
2871:
2867:
2863:
2859:
2855:
2851:
2846:
2842:
2838:
2834:
2830:
2825:
2820:
2816:
2812:
2808:
2803:
2799:
2795:
2790:
2785:
2781:
2777:
2773:
2769:
2765:
2760:
2756:
2752:
2748:
2744:
2739:
2735:
2731:
2727:
2723:
2718:
2714:
2710:
2706:
2702:
2696:
2692:
2688:
2684:
2680:
2676:
2672:
2668:
2664:
2660:
2656:
2651:
2647:
2643:
2639:
2635:
2632:(1): 99–106.
2631:
2627:
2622:
2618:
2614:
2610:
2606:
2600:
2596:
2592:
2587:
2582:
2578:
2574:
2571:(2): 467–78.
2570:
2566:
2562:
2557:
2553:
2549:
2545:
2541:
2537:
2533:
2529:
2525:
2521:
2517:
2512:
2508:
2504:
2499:
2494:
2490:
2486:
2482:
2477:
2473:
2469:
2465:
2461:
2457:
2453:
2449:
2445:
2441:
2437:
2432:
2428:
2424:
2420:
2416:
2411:
2406:
2402:
2398:
2394:
2390:
2386:
2381:
2377:
2373:
2369:
2365:
2361:
2357:
2352:
2351:
2346:
2338:
2334:
2329:
2324:
2320:
2316:
2312:
2305:
2302:
2297:
2293:
2288:
2283:
2279:
2275:
2271:
2267:
2263:
2256:
2253:
2248:
2244:
2239:
2234:
2230:
2226:
2222:
2215:
2212:
2207:
2203:
2199:
2195:
2191:
2187:
2183:
2179:
2175:
2171:
2164:
2161:
2156:
2152:
2147:
2142:
2138:
2134:
2130:
2126:
2122:
2115:
2113:
2109:
2104:
2100:
2095:
2090:
2086:
2082:
2078:
2074:
2070:
2063:
2061:
2057:
2052:
2048:
2044:
2040:
2036:
2032:
2028:
2024:
2020:
2016:
2009:
2006:
2001:
1997:
1993:
1989:
1982:
1980:
1978:
1976:
1972:
1967:
1963:
1958:
1953:
1949:
1945:
1941:
1934:
1931:
1926:
1922:
1918:
1914:
1910:
1906:
1902:
1898:
1894:
1890:
1882:
1879:
1874:
1870:
1866:
1862:
1858:
1854:
1850:
1846:
1839:
1836:
1831:
1827:
1823:
1819:
1815:
1811:
1807:
1803:
1795:
1792:
1787:
1783:
1778:
1773:
1769:
1765:
1761:
1757:
1753:
1749:
1745:
1738:
1735:
1732:
1730:
1724:
1721:
1716:
1712:
1708:
1704:
1700:
1696:
1692:
1688:
1681:
1679:
1675:
1670:
1666:
1661:
1656:
1651:
1646:
1642:
1638:
1634:
1627:
1624:
1619:
1615:
1610:
1605:
1601:
1597:
1593:
1589:
1585:
1578:
1575:
1570:
1564:
1561:
1556:
1552:
1548:
1544:
1540:
1536:
1533:(4): 713–24.
1532:
1528:
1521:
1518:
1513:
1509:
1503:
1500:
1495:
1491:
1485:
1482:
1478:
1474:
1469:
1467:
1465:
1461:
1457:
1453:
1448:
1446:
1444:
1440:
1434:
1430:
1427:
1425:
1422:
1421:
1417:
1411:
1408:
1405:
1402:
1399:
1396:
1393:
1390:
1387:
1384:
1381:
1378:
1375:
1372:
1371:
1369:
1367:
1359:
1357:
1353:
1349:
1347:
1342:
1339:
1335:
1332:
1325:
1323:
1316:
1314:
1312:
1308:
1304:
1299:
1297:
1293:
1290:
1286:
1283:
1279:
1274:
1272:
1269:
1265:
1261:
1257:
1245:
1240:
1236:
1232:
1229:
1225:
1218:
1216:
1213:
1209:
1205:
1201:
1198:
1194:
1190:
1183:
1181:
1175:
1171:
1168:
1162:
1160:
1156:
1152:
1148:
1142:
1138:
1134:
1130:
1126:
1122:
1118:
1115:
1111:
1104:
1102:
1096:
1092:
1089:
1083:
1081:
1077:
1073:
1069:
1063:
1059:
1055:
1051:
1047:
1043:
1039:
1036:
1034:RefSeq (mRNA)
1032:
1025:
1024:
1019:
1015:
1012:
1006:
1005:
1000:
996:
993:
991:
987:
980:
979:
974:
970:
967:
961:
960:
956:
951:
947:
944:
942:
938:
931:
930:
925:
921:
918:
912:
911:
906:
902:
899:
897:
893:
890:
887:
885:
882:
878:
875:
871:
867:
860:
856:
851:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
774:cell division
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
716:
714:
711:
710:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
679:
676:
674:
671:
670:
668:
665:
664:
658:
655:
653:
650:
648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
613:
610:
608:
605:
603:
600:
598:
595:
594:
592:
589:
588:
585:
584:Gene ontology
581:
577:
565:
560:
556:
551:
548:
546:
542:
534:
529:
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
481:
478:
474:
469:
466:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
403:
400:
398:
394:
392:
391:
387:
386:
383:
381:
377:
373:
369:
365:
357:
352:
348:
344:
339:
329:
325:
318:
311:
305:
298:
290:
286:
282:
277:
273:
268:
264:
256:
251:
247:
243:
238:
228:
224:
217:
210:
204:
197:
193:
187:
183:
179:
174:
170:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
113:
108:
101:
96:
91:
80:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
19:
5847:Translocases
5844:
5831:
5818:
5805:
5792:
5782:Transferases
5779:
5766:
5623:Binding site
5054:P70S6 kinase
4974:
3623:Prometaphase
3359:
3193:
3133:
3113:
3101:
3057:
3053:
3004:
3000:
2959:
2955:
2910:
2906:
2857:
2853:
2817:(6): 732–7.
2814:
2810:
2771:
2767:
2746:
2742:
2725:
2721:
2704:
2700:
2658:
2654:
2629:
2625:
2608:
2604:
2568:
2564:
2519:
2515:
2488:
2484:
2439:
2435:
2392:
2388:
2359:
2355:
2321:(7): 714–9.
2318:
2314:
2304:
2269:
2265:
2255:
2228:
2224:
2214:
2173:
2169:
2163:
2128:
2124:
2076:
2072:
2018:
2014:
2008:
1991:
1987:
1947:
1943:
1933:
1892:
1888:
1881:
1848:
1844:
1838:
1805:
1801:
1794:
1751:
1747:
1737:
1728:
1723:
1690:
1686:
1643:(1): 50–63.
1640:
1636:
1626:
1591:
1587:
1577:
1563:
1530:
1526:
1520:
1511:
1502:
1493:
1484:
1429:CDK7 pathway
1363:
1360:Interactions
1354:
1350:
1343:
1336:
1333:
1329:
1320:
1300:
1275:
1267:
1259:
1255:
1254:
1177:
1155:NP_001311007
1151:NP_001311006
1147:NP_001311004
1144:
1137:NP_001311003
1133:NP_001311001
1129:NP_001311000
1125:NP_001310999
1121:NP_001310998
1098:
1080:NM_001324078
1076:NM_001324077
1072:NM_001324075
1068:NM_001324074
1065:
1058:NM_001324072
1054:NM_001324071
1050:NM_001324070
1046:NM_001324069
1021:
1002:
976:
953:
927:
908:
888:
883:
511:vas deferens
483:otic placode
453:zone of skin
445:right testis
395:
388:
354:100,867,447
341:100,839,139
115:External IDs
74:
18:
5618:Active site
5505:(EC 2.7.12)
4892:Polo kinase
4832:Polo kinase
3644:Cytokinesis
3613:Preprophase
3557:checkpoints
3176:PDB gallery
2362:(1): 24–7.
673:nucleoplasm
642:ATP binding
457:skin of leg
437:left testis
253:69,277,430
240:69,234,795
93:Identifiers
5901:Cell cycle
5890:Categories
5821:Isomerases
5795:Hydrolases
5662:Regulation
4183:IκB kinase
3758:2.7.11-12)
3565:Interphase
3555:Phases and
3238:Cell cycle
1479:, May 2017
1458:, May 2017
1435:References
1326:Inhibitors
824:DNA repair
789:cell cycle
399:(ortholog)
136:HomoloGene
5911:EC 2.7.11
5700:EC number
4309:PKC alpha
3688:Apoptosis
3638:Telophase
3628:Metaphase
3423:INK4a/ARF
3046:Gaynor RB
1925:232299392
1909:0304-3835
1895:: 70–79.
1873:208276454
1830:208956241
1808:: 27–37.
1180:NP_034004
1159:NP_001790
1101:NM_009874
1042:NM_001799
874:Orthologs
688:cytoplasm
144:GeneCards
5906:Proteins
5724:Kinetics
5648:Cofactor
5611:Activity
4665:KIAA0999
4560:MAPKAPK5
4555:MAPKAPK3
4550:MAPKAPK2
3633:Anaphase
3618:Prophase
3241:proteins
2992:13266489
2722:Oncogene
2701:Oncogene
2605:Oncogene
2427:15480646
2337:15220921
2247:12527756
2103:10958691
1966:10734072
1917:33741425
1822:31812697
1786:25043025
1687:Oncogene
1669:31462705
1637:Oncogene
1618:27301701
1475:–
1454:–
1418:See also
1380:Cyclin H
1366:interact
1303:cyclin H
1262:, is an
1228:Wikidata
853:Sources:
515:yolk sac
499:calvaria
433:testicle
421:placenta
5880:Biology
5834:Ligases
5604:Enzymes
5324:MAP3K14
5302:MAP3K11
5297:MAP3K10
5287:MAP3K13
5282:MAP3K12
5084:RPS6KC1
5079:RPS6KA1
5074:RPS6KA3
5069:RPS6KA2
5064:RPS6KB2
5049:RPS6KA4
5044:RPS6KA5
4695:Kalirin
4660:SNF1LK2
3899:EIF2AK4
3894:EIF2AK3
3748:Kinases
3702:Meiosis
3609:Mitosis
3601:M phase
3582:S phase
3449:cip/kip
3140:PDBe-KB
3130:UniProt
3076:9054383
3037:4278432
3029:8934526
3009:Bibcode
2984:8849451
2964:Bibcode
2956:Science
2947:8692842
2915:Bibcode
2894:8692841
2862:Bibcode
2841:7244269
2833:8647641
2798:8628270
2755:8521393
2734:8208556
2713:8208544
2691:4369898
2683:8078587
2663:Bibcode
2646:7944411
2617:7936635
2595:7929589
2586:2120215
2552:4321212
2544:7885450
2524:Bibcode
2507:7629134
2472:4282418
2464:7533895
2444:Bibcode
2419:9651670
2397:Bibcode
2376:9570510
2296:9372954
2206:4282418
2198:7533895
2178:Bibcode
2155:9130708
2146:1169767
2051:4369898
2043:8078587
2023:Bibcode
2000:8521393
1865:3176087
1777:4244910
1756:Bibcode
1715:6281777
1707:9840937
1660:6937212
1609:5293170
1555:2996948
1547:8069918
1477:Ensembl
1456:Ensembl
990:UniProt
941:Ensembl
880:Species
859:QuickGO
683:nucleus
374:pattern
100:Aliases
5866:Portal
5808:Lyases
5554:MAP2K7
5549:MAP2K6
5544:MAP2K5
5539:MAP2K4
5534:MAP2K3
5529:MAP2K2
5524:MAP2K1
5475:ACVRL1
5470:ACVR2B
5465:ACVR2A
5460:ACVR1C
5455:ACVR1B
5438:BMPR1B
5433:BMPR1A
5307:MAP3K7
5292:MAP3K9
5243:MAP3K8
5238:MAP3K7
5233:MAP3K6
5228:MAP3K5
5223:MAP3K4
5218:MAP3K3
5213:MAP3K2
5208:MAP3K1
5182:MAPK14
5177:MAPK13
5172:MAPK11
5160:MAPK10
5138:MAPK15
5133:MAPK12
5025:CDC2L1
5000:CDC2L5
4675:SNF1LK
4500:CAMK2G
4495:CAMK2D
4490:CAMK2B
4485:CAMK2A
4475:CAMK1G
4470:CAMK1D
4465:CAMK1B
4460:CAMK1A
4314:PRKCB1
4251:PRKACA
4246:PRKACB
4241:PRKACG
4217:IKBKAP
4043:BCKDHB
4038:BCKDHA
4012:PRKAG3
4007:PRKAG2
4002:PRKAG1
3992:PRKAB2
3987:PRKAB1
3977:PRKAA2
3972:PRKAA1
3817:STK38L
3541:Cullin
3427:p14arf
3249:Cyclin
3135:P50613
3097:(MeSH)
3074:
3035:
3027:
3001:Nature
2990:
2982:
2945:
2935:
2892:
2882:
2839:
2831:
2796:
2789:231191
2786:
2753:
2732:
2711:
2689:
2681:
2655:Nature
2644:
2615:
2593:
2583:
2550:
2542:
2516:Nature
2505:
2470:
2462:
2436:Nature
2425:
2417:
2374:
2335:
2294:
2287:232579
2284:
2245:
2204:
2196:
2170:Nature
2153:
2143:
2101:
2091:
2049:
2041:
2015:Nature
1998:
1964:
1923:
1915:
1907:
1871:
1863:
1828:
1820:
1784:
1774:
1748:Nature
1713:
1705:
1667:
1657:
1616:
1606:
1553:
1545:
1404:SUPT5H
1386:GTF2H1
1368:with:
1287:, and
1264:enzyme
1214:search
1212:PubMed
1023:Q03147
1004:P50613
896:Entrez
545:BioGPS
507:morula
232:5q13.2
132:102956
124:601955
5760:Types
5516:MAP2K
5450:ACVR1
5443:BMPR2
5428:BMPR1
5353:GSK-3
5194:MAP3K
5155:MAPK9
5150:MAPK8
5128:MAPK7
5123:MAPK6
5118:MAPK4
5113:MAPK3
5108:MAPK1
5020:PFTK1
5015:PCTK3
5010:PCTK2
5005:PCTK1
4995:CDK12
4990:CDK10
4965:CDKL5
4945:CDKL2
4822:STK19
4817:EEF2K
4798:PHKG2
4793:PHKG1
4783:PHKA2
4778:PHKA1
4759:MYLK4
4754:MYLK3
4749:MYLK2
4725:DCLK1
4720:Titin
4710:TRIB3
4705:TRIB2
4700:TRIB1
4690:TSSK2
4670:STK40
4655:PSKH1
4650:PRKD3
4645:PRKD2
4625:PHKG2
4620:PHKG1
4610:OBSCN
4605:NUAK2
4600:NUAK1
4595:MKNK2
4590:MKNK1
4580:MARK4
4575:MARK3
4570:MARK2
4565:MARK1
4545:STK11
4540:DAPK3
4535:DAPK2
4530:DAPK1
4525:CHEK2
4520:CHEK1
4505:CAMK4
4480:CAMK2
4455:CAMK1
4450:BRSK2
4344:PRKCQ
4339:PRKCI
4334:PRKCG
4329:PRKCH
4324:PRKCE
4319:PRKCD
4280:PRKG1
4212:IKBKG
4207:IKBKE
4156:STK10
4151:FASTK
4077:IDH3G
4072:IDH3B
4067:IDH3A
4033:BCKDK
3827:ROCK1
3812:STK38
3807:MAST2
3802:MAST1
3797:LATS2
3792:LATS1
3697:phase
3591:phase
3577:phase
3516:Cdc42
3511:Cdc25
3499:Other
3281:, B3)
3033:S2CID
2988:S2CID
2938:39050
2885:39049
2837:S2CID
2687:S2CID
2548:S2CID
2468:S2CID
2423:S2CID
2202:S2CID
2094:88771
2047:S2CID
1921:S2CID
1869:S2CID
1826:S2CID
1731:2017
1711:S2CID
1551:S2CID
1406:, and
1392:MNAT1
1311:TFIIH
1285:cdc28
1258:, or
929:12572
889:Mouse
884:Human
855:Amigo
425:gonad
397:Mouse
390:Human
337:Start
272:Mouse
236:Start
169:Human
5852:list
5845:EC7
5839:list
5832:EC6
5826:list
5819:EC5
5813:list
5806:EC4
5800:list
5793:EC3
5787:list
5780:EC2
5774:list
5767:EC1
5343:TPK1
5319:CDC7
5277:MLKs
5270:KSR2
5265:KSR1
5260:BRAF
5255:ARAF
5250:RAFs
4985:CDK9
4980:CDK8
4975:CDK7
4970:CDK6
4960:CDK5
4955:CDK4
4950:CDK3
4940:CDK2
4935:CDK1
4916:PLK4
4911:PLK3
4906:PLK2
4901:PLK1
4856:PLK4
4851:PLK3
4846:PLK2
4841:PLK1
4788:PHKB
4744:MYLK
4715:TRIO
4685:SPEG
4680:SNRK
4640:PKD1
4635:PIM2
4630:PIM1
4615:PASK
4585:MELK
4515:CASK
4510:MLCK
4431:GRK6
4426:GRK5
4421:GRK4
4359:PKN3
4354:PKN2
4256:PRKY
4202:TBK1
4197:IKK2
4192:CHUK
4096:STK4
4062:IDH2
3947:PDK4
3942:PDK3
3937:PDK2
3932:PDK1
3911:WEE1
3906:Wee1
3874:mTOR
3862:AKT3
3857:AKT2
3852:AKT1
3842:SGK3
3837:SGK2
3545:CUL7
3506:Cdc2
3194:1ua2
3128:for
3114:CDK7
3102:CDK7
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