304:
281:
178:
203:
555:
2686:
310:
209:
31:
1231:
protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have
1915:
Wong AK, Shanahan F, Chen Y, Lian L, Ha P, Hendricks K, Ghaffari S, Iliev D, Penn B, Woodland AM, Smith R, Salada G, Carillo A, Laity K, Gupte J, Swedlund B, Tavtigian SV, Teng DH, Lees E (November 2000). "BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines".
57:
1838:
Mitsui K, Nakanishi M, Ohtsuka S, Norwood TH, Okabayashi K, Miyamoto C, Tanaka K, Yoshimura A, Ohtsubo M (December 1999). "A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins".
1223:. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to
1674:
Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM (September 1992). "Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle".
2475:
Li H, Lahti JM, Valentine M, Saito M, Reed SI, Look AT, Kidd VJ (1997). "Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors".
2046:
Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM (1992). "Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle".
2121:
Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH (1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)".
2084:
Koff A, Cross F, Fisher A, Schumacher J, Leguellec K, Philippe M, Roberts JM (1991). "Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family".
317:
216:
2376:
Geng Y, Eaton EN, Picón M, Roberts JM, Lundberg AS, Gifford A, Sardet C, Weinberg RA (1996). "Regulation of cyclin E transcription by E2Fs and retinoblastoma protein".
1721:
McKenzie PP, Danks MK, Kriwacki RW, Harris LC (July 2003). "P21Waf1/Cip1 dysfunction in neuroblastoma: a novel mechanism of attenuating G0-G1 cell cycle arrest".
2726:
2009:
Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA (1992). "Regulation of retinoblastoma protein functions by ectopic expression of human cyclins".
883:
139:
54:
3018:
2912:
2264:"The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E."
864:
1876:"The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E"
1482:"Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest"
3224:
2665:
1394:
2685:
2958:
1376:
1207:, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of
303:
2602:"Cyclin ET, a new splice variant of human cyclin E with a unique expression pattern during cell cycle progression and differentiation"
1119:
2719:
1126:
280:
1412:
Lew DJ, Dulić V, Reed SI (October 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast".
1797:
Boudrez A, Beullens M, Groenen P, Van Eynde A, Vulsteke V, Jagiello I, Murray M, Krainer AR, Stalmans W, Bollen M (August 2000).
2399:"Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage"
1455:
1232:
been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.
2547:
Sala A, Kundu M, Casella I, Engelhard A, Calabretta B, Grasso L, Paggi MG, Giordano A, Watson RJ, Khalili K, Peschle C (1997).
1363:
1342:
1211:. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each
2507:"Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E."
3229:
202:
177:
1359:
1290:
1573:
Connor MK, Kotchetkov R, Cariou S, Resch A, Lupetti R, Beniston RG, Melchior F, Hengst L, Slingerland JM (January 2003).
1338:
2712:
119:
3028:
1970:
1241:
1575:"CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis"
316:
215:
1799:"NIPP1-mediated interaction of protein phosphatase-1 with CDC5L, a regulator of pre-mRNA splicing and mitotic entry"
3169:
2872:
309:
208:
2867:
2862:
2857:
2852:
2847:
2842:
2837:
2832:
2827:
2658:
2298:"Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25"
2221:"Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1"
1531:"Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25"
1272:
1201:
928:
127:
2819:
1750:"mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability"
1208:
909:
3151:
2902:
191:
2651:
2560:
2056:
1966:"A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapy"
1684:
1081:
1071:
106:
2194:
Sewing A, Rönicke V, Bürger C, Funk M, Müller R (1994). "Alternative splicing of human cyclin E.".
1067:
1063:
1059:
1014:
1010:
1006:
3164:
2969:
2109:
2034:
1437:
151:
1102:
1055:
1035:
1002:
998:
3159:
2631:
2588:
2535:
2493:
2463:
2420:
2385:
2364:
2319:
2284:
2250:
2207:
2182:
2139:
2101:
2072:
2026:
1997:
1952:
1925:
1897:
1856:
1820:
1779:
1730:
1700:
1653:
1604:
1552:
1511:
1429:
99:
47:
2621:
2613:
2578:
2568:
2525:
2517:
2485:
2453:
2445:
2410:
2354:
2344:
2309:
2274:
2240:
2232:
2199:
2172:
2164:
2131:
2093:
2064:
2018:
1987:
1979:
1887:
1848:
1810:
1769:
1761:
1692:
1643:
1635:
1594:
1586:
1542:
1501:
1493:
1421:
396:
327:
271:
226:
554:
147:
1220:
371:
2564:
2060:
1688:
2521:
1992:
1965:
1227:. This protein was found to associate with, and be involved in, the phosphorylation of
30:
2626:
2601:
2530:
2506:
2458:
2433:
2245:
2220:
2177:
2152:
1774:
1749:
1648:
1624:"Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells"
1623:
1599:
1574:
1506:
1481:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
677:
672:
667:
662:
657:
652:
647:
631:
626:
621:
616:
611:
606:
601:
596:
3218:
3098:
2583:
2548:
2359:
2332:
2236:
2097:
2022:
1425:
1315:
1224:
583:
2113:
2038:
1441:
3120:
389:
168:
131:
1215:
event. This cyclin forms a complex with and functions as a regulatory subunit of
155:
3141:
3110:
1399:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1381:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1228:
472:
3062:
2946:
2735:
2153:"Human cyclin E, a nuclear protein essential for the G1-to-S phase transition"
288:
185:
135:
2617:
2415:
2398:
2349:
1983:
704:
regulation of transcription involved in G1/S transition of mitotic cell cycle
3185:
3135:
3125:
2808:
2794:
2790:
2786:
2776:
2772:
2762:
2758:
2068:
1696:
1590:
828:
532:
410:
355:
342:
254:
241:
143:
2489:
2314:
2297:
2279:
2263:
2001:
1956:
1929:
1892:
1875:
1860:
1852:
1824:
1815:
1798:
1783:
1734:
1657:
1639:
1608:
1547:
1530:
2635:
2592:
2573:
2539:
2497:
2467:
2449:
2424:
2389:
2368:
2323:
2288:
2254:
2211:
2203:
2186:
2168:
2143:
2105:
2076:
2030:
1901:
1704:
1556:
1515:
1497:
1433:
1166:
3190:
3130:
3115:
3084:
3070:
2800:
2782:
2768:
2754:
1310:
1150:
973:
954:
1161:
3199:
3106:
3079:
2738:
1765:
1296:
1212:
1182:
940:
895:
769:
regulation of cyclin-dependent protein serine/threonine kinase activity
2704:
2135:
76:
3038:
2954:
2940:
2936:
2932:
2924:
2882:
2877:
2746:
1255:
1249:
1204:
1134:
850:
2151:
Ohtsubo M, Theodoras AM, Schumacher J, Roberts JM, Pagano M (1995).
1480:
Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E (February 1999).
607:
cyclin-dependent protein serine/threonine kinase regulator activity
3013:
3008:
2897:
2892:
2887:
1622:
Singer JD, Gurian-West M, Clurman B, Roberts JM (September 1999).
1278:
2434:"Cyclin-binding motifs are essential for the function of p21CIP1"
813:
809:
3042:
3033:
3003:
2982:
2920:
1266:
1261:
1216:
1189:
123:
2708:
2647:
2219:
Dyson N, Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K (1993).
3023:
2987:
2977:
2950:
2928:
2643:
2600:
Mumberg D, Wick M, Bürger C, Haas K, Funk M, Müller R (1997).
2333:"Regulation of the cyclin E gene by transcription factor E2F1"
1284:
563:
1874:
Li Y, Graham C, Lacy S, Duncan AM, Whyte P (December 1993).
794:
positive regulation of G1/S transition of mitotic cell cycle
2432:
Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A (1996).
744:
negative regulation of transcription by RNA polymerase II
627:
cyclin-dependent protein serine/threonine kinase activity
379:
759:
chromosome organization involved in meiotic cell cycle
2694:: THE STRUCTURAL BASIS OF CDK2 ACTIVATION BY CYCLIN E
544:
784:
positive regulation of cell population proliferation
3178:
3150:
3097:
3061:
3052:
2996:
2968:
2911:
2818:
2745:
2262:Li Y, Graham C, Lacy S, Duncan AM, Whyte P (1994).
1748:Mayer C, Zhao J, Yuan X, Grummt I (February 2004).
1095:
1054:
1028:
991:
719:
positive regulation of transcription, DNA-templated
1355:
1353:
1351:
1334:
1332:
1330:
653:cyclin-dependent protein kinase holoenzyme complex
326:
225:
2397:Poon RY, Jiang W, Toyoshima H, Hunter T (1996).
1200:The protein encoded by this gene belongs to the
1716:
1714:
18:Protein-coding gene in the species Homo sapiens
1669:
1667:
1568:
1566:
1360:GRCm38: Ensembl release 89: ENSMUSG00000002068
2720:
2659:
1475:
1473:
1471:
1469:
1467:
1465:
8:
1219:, whose activity is required for cell cycle
1339:GRCh38: Ensembl release 89: ENSG00000105173
3058:
2727:
2713:
2705:
2666:
2652:
2644:
1051:
824:
579:
367:
266:
163:
65:
3019:Cellular apoptosis susceptibility protein
2625:
2582:
2572:
2529:
2457:
2414:
2358:
2348:
2331:Ohtani K, DeGregori J, Nevins JR (1996).
2313:
2278:
2244:
2176:
1991:
1964:Mazumder S, DuPree EL, Almasan A (2004).
1891:
1814:
1773:
1647:
1598:
1546:
1505:
507:fetal liver hematopoietic progenitor cell
754:homologous chromosome pairing at meiosis
2681:
1326:
2549:"Activation of human B-MYB by cyclins"
779:regulation of mitotic nuclear division
20:
764:G1/S transition of mitotic cell cycle
739:regulation of protein kinase activity
331:
292:
287:
230:
189:
184:
7:
799:mitotic cell cycle phase transition
694:androgen receptor signaling pathway
2522:10.1002/j.1460-2075.1996.tb00793.x
1092:
1025:
988:
964:
945:
919:
900:
874:
855:
597:transcription coactivator activity
549:
467:
405:
384:
14:
1185:that in humans is encoded by the
789:positive regulation of cell cycle
2684:
2237:10.1128/JVI.67.12.7641-7647.1993
553:
315:
308:
302:
279:
214:
207:
201:
176:
29:
1456:"Entrez Gene: CCNE1 cyclin E1"
564:More reference expression data
533:More reference expression data
1:
1841:Biochem. Biophys. Res. Commun
1529:Xu X, Burke SP (March 1996).
1291:Retinoblastoma-like protein 2
300:
199:
3225:Genes on human chromosome 19
2553:Proc. Natl. Acad. Sci. U.S.A
2337:Proc. Natl. Acad. Sci. U.S.A
2098:10.1016/0092-8674(91)90044-Y
2023:10.1016/0092-8674(92)90249-C
1426:10.1016/0092-8674(91)90042-W
1240:Cyclin E1 has been shown to
3029:Maturation promoting factor
2198:. 107. ( Pt 2) (2): 581–8.
1971:Current Cancer Drug Targets
3246:
3170:Postreplication checkpoint
729:DNA replication initiation
457:mucosa of transverse colon
2679:
1395:"Mouse PubMed Reference:"
1377:"Human PubMed Reference:"
1273:Cyclin-dependent kinase 2
1165:
1160:
1156:
1149:
1133:
1114:
1099:
1078:
1047:
1032:
995:
984:
971:
967:
952:
948:
939:
926:
922:
907:
903:
894:
881:
877:
862:
858:
849:
834:
827:
823:
807:
617:androgen receptor binding
582:
578:
561:
552:
543:
530:
479:
470:
417:
408:
378:
370:
366:
349:
336:
299:
278:
269:
265:
248:
235:
198:
175:
166:
162:
117:
114:
104:
97:
92:
73:
68:
51:
46:
41:
37:
28:
23:
2505:Won KA, Reed SI (1996).
2416:10.1074/jbc.271.22.13283
2350:10.1073/pnas.92.26.12146
1984:10.2174/1568009043481669
1120:Chr 19: 29.81 – 29.82 Mb
709:regulation of cell cycle
2296:Xu X, Burke SP (1996).
2069:10.1126/science.1388288
1951:. 60. Suppl 5: 267–71.
1697:10.1126/science.1388288
1591:10.1091/mbc.E02-06-0319
1179:G1/S-specific cyclin-E1
724:protein phosphorylation
632:protein kinase activity
503:internal carotid artery
3152:Cell cycle checkpoints
2618:10.1093/nar/25.11.2098
2490:10.1006/geno.1996.0112
2315:10.1074/jbc.271.9.5118
2280:10.1101/gad.7.12a.2366
1893:10.1101/gad.7.12a.2366
1853:10.1006/bbrc.1999.1777
1816:10.1074/jbc.M001676200
1640:10.1101/gad.13.18.2375
1548:10.1074/jbc.271.9.5118
1127:Chr 7: 37.8 – 37.81 Mb
668:cyclin E1-CDK2 complex
622:protein kinase binding
3230:Cell cycle regulators
3179:Other cellular phases
2903:CDK-activating kinase
2574:10.1073/pnas.94.2.532
2450:10.1128/MCB.16.9.4673
2204:10.1242/jcs.107.2.581
2169:10.1128/mcb.15.5.2612
2124:Cytogenet. Cell Genet
1498:10.1128/mcb.19.2.1460
699:Wnt signaling pathway
519:mandibular prominence
192:Chromosome 19 (human)
1947:Akita H (2003). "".
749:telomere maintenance
333:7 B3|7 25.35 cM
294:Chromosome 7 (mouse)
69:List of PDB id codes
42:Available structures
2565:1997PNAS...94..532S
2061:1992Sci...257.1689K
1689:1992Sci...257.1689K
453:gingival epithelium
3165:Spindle checkpoint
2970:P53 p63 p73 family
1766:10.1101/gad.285504
929:ENSMUSG00000002068
774:mitotic cell cycle
687:Biological process
641:Cellular component
590:Molecular function
110:, CCNE, pcyclin E1
3212:
3211:
3208:
3207:
3160:Restriction point
2702:
2701:
2606:Nucleic Acids Res
2136:10.1159/000133960
2055:(5077): 1689–94.
1683:(5077): 1689–94.
1176:
1175:
1172:
1171:
1145:
1144:
1110:
1109:
1089:
1088:
1043:
1042:
1022:
1021:
980:
979:
961:
960:
935:
934:
916:
915:
890:
889:
871:
870:
819:
818:
574:
573:
570:
569:
539:
538:
526:
525:
464:
463:
362:
361:
261:
260:
156:CCNE1 - orthologs
88:
87:
84:
83:
52:Ortholog search:
3237:
3059:
2729:
2722:
2715:
2706:
2688:
2668:
2661:
2654:
2645:
2639:
2629:
2612:(11): 2098–105.
2596:
2586:
2576:
2543:
2533:
2501:
2471:
2461:
2428:
2418:
2409:(22): 13283–91.
2393:
2372:
2362:
2352:
2343:(26): 12146–50.
2327:
2317:
2292:
2282:
2273:(12A): 2366–77.
2258:
2248:
2215:
2190:
2180:
2147:
2117:
2080:
2042:
2005:
1995:
1960:
1934:
1933:
1912:
1906:
1905:
1895:
1886:(12A): 2366–77.
1871:
1865:
1864:
1835:
1829:
1828:
1818:
1794:
1788:
1787:
1777:
1745:
1739:
1738:
1718:
1709:
1708:
1671:
1662:
1661:
1651:
1619:
1613:
1612:
1602:
1570:
1561:
1560:
1550:
1526:
1520:
1519:
1509:
1477:
1460:
1459:
1452:
1446:
1445:
1409:
1403:
1402:
1391:
1385:
1384:
1373:
1367:
1357:
1346:
1336:
1202:highly conserved
1158:
1157:
1129:
1122:
1105:
1093:
1084:
1052:
1048:RefSeq (protein)
1038:
1026:
1017:
989:
965:
946:
920:
901:
875:
856:
825:
580:
566:
557:
550:
535:
511:primitive streak
475:
473:Top expressed in
468:
421:secondary oocyte
413:
411:Top expressed in
406:
385:
368:
358:
345:
334:
319:
312:
306:
295:
283:
267:
257:
244:
233:
218:
211:
205:
194:
180:
164:
158:
109:
102:
79:
66:
60:
39:
38:
33:
21:
3245:
3244:
3240:
3239:
3238:
3236:
3235:
3234:
3215:
3214:
3213:
3204:
3194:
3174:
3146:
3093:
3088:
3074:
3054:
3048:
2992:
2964:
2907:
2814:
2741:
2733:
2703:
2698:
2695:
2689:
2675:
2672:
2642:
2599:
2546:
2516:(16): 4182–93.
2504:
2474:
2438:Mol. Cell. Biol
2431:
2396:
2375:
2330:
2295:
2261:
2218:
2193:
2157:Mol. Cell. Biol
2150:
2120:
2083:
2045:
2017:(6): 993–1006.
2008:
1963:
1946:
1942:
1940:Further reading
1937:
1914:
1913:
1909:
1873:
1872:
1868:
1837:
1836:
1832:
1809:(33): 25411–7.
1796:
1795:
1791:
1747:
1746:
1742:
1720:
1719:
1712:
1673:
1672:
1665:
1634:(18): 2375–87.
1621:
1620:
1616:
1579:Mol. Biol. Cell
1572:
1571:
1564:
1528:
1527:
1523:
1486:Mol. Cell. Biol
1479:
1478:
1463:
1454:
1453:
1449:
1420:(6): 1197–206.
1411:
1410:
1406:
1393:
1392:
1388:
1375:
1374:
1370:
1358:
1349:
1337:
1328:
1324:
1307:
1302:
1238:
1221:G1/S transition
1198:
1167:View/Edit Mouse
1162:View/Edit Human
1125:
1118:
1115:Location (UCSC)
1101:
1080:
1074:
1070:
1066:
1062:
1058:
1034:
1013:
1009:
1005:
1001:
997:
910:ENSG00000105173
803:
682:
636:
612:protein binding
602:kinase activity
562:
531:
522:
517:
513:
509:
505:
501:
497:
493:
489:
485:
471:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
353:
340:
332:
322:
321:
320:
313:
293:
270:Gene location (
252:
239:
231:
221:
220:
219:
212:
190:
167:Gene location (
118:
105:
98:
75:
53:
19:
12:
11:
5:
3243:
3241:
3233:
3232:
3227:
3217:
3216:
3210:
3209:
3206:
3205:
3203:
3202:
3197:
3192:
3188:
3182:
3180:
3176:
3175:
3173:
3172:
3167:
3162:
3156:
3154:
3148:
3147:
3145:
3144:
3139:
3133:
3128:
3123:
3118:
3113:
3103:
3101:
3095:
3094:
3092:
3091:
3086:
3082:
3077:
3072:
3067:
3065:
3056:
3050:
3049:
3047:
3046:
3036:
3031:
3026:
3021:
3016:
3011:
3006:
3000:
2998:
2994:
2993:
2991:
2990:
2985:
2980:
2974:
2972:
2966:
2965:
2963:
2962:
2944:
2917:
2915:
2909:
2908:
2906:
2905:
2900:
2895:
2890:
2885:
2880:
2875:
2870:
2865:
2860:
2855:
2850:
2845:
2840:
2835:
2830:
2824:
2822:
2816:
2815:
2813:
2812:
2798:
2780:
2766:
2751:
2749:
2743:
2742:
2734:
2732:
2731:
2724:
2717:
2709:
2700:
2699:
2697:
2696:
2690:
2683:
2680:
2677:
2676:
2673:
2671:
2670:
2663:
2656:
2648:
2641:
2640:
2597:
2544:
2502:
2472:
2444:(9): 4673–82.
2429:
2394:
2384:(6): 1173–80.
2373:
2328:
2308:(9): 5118–24.
2293:
2259:
2231:(12): 7641–7.
2216:
2191:
2163:(5): 2612–24.
2148:
2130:(3–4): 190–2.
2118:
2092:(6): 1217–28.
2081:
2043:
2006:
1961:
1943:
1941:
1938:
1936:
1935:
1924:(21): 6171–7.
1907:
1866:
1830:
1789:
1740:
1729:(13): 3840–4.
1710:
1663:
1614:
1562:
1541:(9): 5118–24.
1521:
1461:
1447:
1404:
1386:
1368:
1347:
1325:
1323:
1320:
1319:
1318:
1313:
1306:
1303:
1301:
1300:
1294:
1288:
1282:
1276:
1270:
1264:
1259:
1253:
1246:
1237:
1234:
1197:
1194:
1174:
1173:
1170:
1169:
1164:
1154:
1153:
1147:
1146:
1143:
1142:
1140:
1138:
1131:
1130:
1123:
1116:
1112:
1111:
1108:
1107:
1097:
1096:
1090:
1087:
1086:
1082:NP_001309190.1
1076:
1075:
1072:NP_001309188.1
1049:
1045:
1044:
1041:
1040:
1030:
1029:
1023:
1020:
1019:
993:
992:
986:
982:
981:
978:
977:
969:
968:
962:
959:
958:
950:
949:
943:
937:
936:
933:
932:
924:
923:
917:
914:
913:
905:
904:
898:
892:
891:
888:
887:
879:
878:
872:
869:
868:
860:
859:
853:
847:
846:
841:
836:
832:
831:
821:
820:
817:
816:
805:
804:
802:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
690:
688:
684:
683:
681:
680:
675:
670:
665:
660:
655:
650:
644:
642:
638:
637:
635:
634:
629:
624:
619:
614:
609:
604:
599:
593:
591:
587:
586:
576:
575:
572:
571:
568:
567:
559:
558:
547:
541:
540:
537:
536:
528:
527:
524:
523:
521:
520:
516:
512:
508:
504:
500:
496:
492:
488:
484:
480:
477:
476:
465:
462:
461:
459:
458:
454:
450:
449:amniotic fluid
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
402:
401:
393:
382:
376:
375:
372:RNA expression
364:
363:
360:
359:
351:
347:
346:
338:
335:
330:
324:
323:
314:
307:
301:
297:
296:
291:
285:
284:
276:
275:
263:
262:
259:
258:
250:
246:
245:
237:
234:
229:
223:
222:
213:
206:
200:
196:
195:
188:
182:
181:
173:
172:
160:
159:
116:
112:
111:
103:
95:
94:
90:
89:
86:
85:
82:
81:
71:
70:
62:
61:
50:
44:
43:
35:
34:
26:
25:
17:
13:
10:
9:
6:
4:
3:
2:
3242:
3231:
3228:
3226:
3223:
3222:
3220:
3201:
3198:
3196:
3189:
3187:
3184:
3183:
3181:
3177:
3171:
3168:
3166:
3163:
3161:
3158:
3157:
3155:
3153:
3149:
3143:
3140:
3137:
3134:
3132:
3129:
3127:
3124:
3122:
3119:
3117:
3114:
3112:
3108:
3105:
3104:
3102:
3100:
3096:
3090:
3083:
3081:
3078:
3076:
3069:
3068:
3066:
3064:
3060:
3057:
3051:
3044:
3040:
3037:
3035:
3032:
3030:
3027:
3025:
3022:
3020:
3017:
3015:
3012:
3010:
3007:
3005:
3002:
3001:
2999:
2995:
2989:
2986:
2984:
2981:
2979:
2976:
2975:
2973:
2971:
2967:
2960:
2956:
2952:
2948:
2945:
2942:
2938:
2934:
2930:
2926:
2922:
2919:
2918:
2916:
2914:
2913:CDK inhibitor
2910:
2904:
2901:
2899:
2896:
2894:
2891:
2889:
2886:
2884:
2881:
2879:
2876:
2874:
2871:
2869:
2866:
2864:
2861:
2859:
2856:
2854:
2851:
2849:
2846:
2844:
2841:
2839:
2836:
2834:
2831:
2829:
2826:
2825:
2823:
2821:
2817:
2810:
2806:
2802:
2799:
2796:
2792:
2788:
2784:
2781:
2778:
2774:
2770:
2767:
2764:
2760:
2756:
2753:
2752:
2750:
2748:
2744:
2740:
2737:
2730:
2725:
2723:
2718:
2716:
2711:
2710:
2707:
2693:
2687:
2682:
2678:
2669:
2664:
2662:
2657:
2655:
2650:
2649:
2646:
2637:
2633:
2628:
2623:
2619:
2615:
2611:
2607:
2603:
2598:
2594:
2590:
2585:
2580:
2575:
2570:
2566:
2562:
2558:
2554:
2550:
2545:
2541:
2537:
2532:
2527:
2523:
2519:
2515:
2511:
2508:
2503:
2499:
2495:
2491:
2487:
2483:
2479:
2473:
2469:
2465:
2460:
2455:
2451:
2447:
2443:
2439:
2435:
2430:
2426:
2422:
2417:
2412:
2408:
2404:
2403:J. Biol. Chem
2400:
2395:
2391:
2387:
2383:
2379:
2374:
2370:
2366:
2361:
2356:
2351:
2346:
2342:
2338:
2334:
2329:
2325:
2321:
2316:
2311:
2307:
2303:
2302:J. Biol. Chem
2299:
2294:
2290:
2286:
2281:
2276:
2272:
2268:
2265:
2260:
2256:
2252:
2247:
2242:
2238:
2234:
2230:
2226:
2222:
2217:
2213:
2209:
2205:
2201:
2197:
2192:
2188:
2184:
2179:
2174:
2170:
2166:
2162:
2158:
2154:
2149:
2145:
2141:
2137:
2133:
2129:
2125:
2119:
2115:
2111:
2107:
2103:
2099:
2095:
2091:
2087:
2082:
2078:
2074:
2070:
2066:
2062:
2058:
2054:
2050:
2044:
2040:
2036:
2032:
2028:
2024:
2020:
2016:
2012:
2007:
2003:
1999:
1994:
1989:
1985:
1981:
1977:
1973:
1972:
1967:
1962:
1958:
1954:
1950:
1949:Nippon Rinsho
1945:
1944:
1939:
1931:
1927:
1923:
1919:
1911:
1908:
1903:
1899:
1894:
1889:
1885:
1881:
1877:
1870:
1867:
1862:
1858:
1854:
1850:
1847:(1): 115–22.
1846:
1842:
1834:
1831:
1826:
1822:
1817:
1812:
1808:
1804:
1803:J. Biol. Chem
1800:
1793:
1790:
1785:
1781:
1776:
1771:
1767:
1763:
1760:(4): 423–34.
1759:
1755:
1751:
1744:
1741:
1736:
1732:
1728:
1724:
1717:
1715:
1711:
1706:
1702:
1698:
1694:
1690:
1686:
1682:
1678:
1670:
1668:
1664:
1659:
1655:
1650:
1645:
1641:
1637:
1633:
1629:
1625:
1618:
1615:
1610:
1606:
1601:
1596:
1592:
1588:
1585:(1): 201–13.
1584:
1580:
1576:
1569:
1567:
1563:
1558:
1554:
1549:
1544:
1540:
1536:
1535:J. Biol. Chem
1532:
1525:
1522:
1517:
1513:
1508:
1503:
1499:
1495:
1492:(2): 1460–9.
1491:
1487:
1483:
1476:
1474:
1472:
1470:
1468:
1466:
1462:
1457:
1451:
1448:
1443:
1439:
1435:
1431:
1427:
1423:
1419:
1415:
1408:
1405:
1400:
1396:
1390:
1387:
1382:
1378:
1372:
1369:
1365:
1361:
1356:
1354:
1352:
1348:
1344:
1340:
1335:
1333:
1331:
1327:
1321:
1317:
1316:Cyclin E/Cdk2
1314:
1312:
1309:
1308:
1304:
1298:
1295:
1292:
1289:
1286:
1283:
1280:
1277:
1274:
1271:
1268:
1265:
1263:
1260:
1257:
1254:
1251:
1248:
1247:
1245:
1243:
1235:
1233:
1230:
1226:
1225:tumorigenesis
1222:
1218:
1214:
1210:
1206:
1205:cyclin family
1203:
1195:
1193:
1191:
1188:
1184:
1180:
1168:
1163:
1159:
1155:
1152:
1148:
1141:
1139:
1136:
1132:
1128:
1124:
1121:
1117:
1113:
1106:
1104:
1098:
1094:
1091:
1085:
1083:
1077:
1073:
1069:
1065:
1061:
1057:
1053:
1050:
1046:
1039:
1037:
1031:
1027:
1024:
1018:
1016:
1012:
1008:
1004:
1000:
994:
990:
987:
985:RefSeq (mRNA)
983:
976:
975:
970:
966:
963:
957:
956:
951:
947:
944:
942:
938:
931:
930:
925:
921:
918:
912:
911:
906:
902:
899:
897:
893:
886:
885:
880:
876:
873:
867:
866:
861:
857:
854:
852:
848:
845:
842:
840:
837:
833:
830:
826:
822:
815:
811:
806:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
714:cell division
712:
710:
707:
705:
702:
700:
697:
695:
692:
691:
689:
686:
685:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
645:
643:
640:
639:
633:
630:
628:
625:
623:
620:
618:
615:
613:
610:
608:
605:
603:
600:
598:
595:
594:
592:
589:
588:
585:
584:Gene ontology
581:
577:
565:
560:
556:
551:
548:
546:
542:
534:
529:
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
481:
478:
474:
469:
466:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
403:
400:
398:
394:
392:
391:
387:
386:
383:
381:
377:
373:
369:
365:
357:
352:
348:
344:
339:
329:
325:
318:
311:
305:
298:
290:
286:
282:
277:
273:
268:
264:
256:
251:
247:
243:
238:
228:
224:
217:
210:
204:
197:
193:
187:
183:
179:
174:
170:
165:
161:
157:
153:
149:
145:
141:
137:
133:
129:
125:
121:
113:
108:
101:
96:
91:
80:
78:
72:
67:
64:
63:
59:
56:
49:
45:
40:
36:
32:
27:
22:
16:
3121:Prometaphase
2804:
2691:
2609:
2605:
2559:(2): 532–6.
2556:
2552:
2513:
2509:
2484:(2): 253–9.
2481:
2477:
2441:
2437:
2406:
2402:
2381:
2377:
2340:
2336:
2305:
2301:
2270:
2266:
2228:
2224:
2195:
2160:
2156:
2127:
2123:
2089:
2085:
2052:
2048:
2014:
2010:
1978:(1): 65–75.
1975:
1969:
1948:
1921:
1917:
1910:
1883:
1879:
1869:
1844:
1840:
1833:
1806:
1802:
1792:
1757:
1753:
1743:
1726:
1722:
1680:
1676:
1631:
1627:
1617:
1582:
1578:
1538:
1534:
1524:
1489:
1485:
1450:
1417:
1413:
1407:
1398:
1389:
1380:
1371:
1239:
1236:Interactions
1199:
1186:
1178:
1177:
1100:
1079:
1068:NP_001309191
1064:NP_001309190
1060:NP_001309188
1033:
1015:NM_001322262
1011:NM_001322261
1007:NM_001322259
996:
972:
953:
927:
908:
882:
863:
843:
838:
445:right testis
395:
388:
115:External IDs
74:
15:
3142:Cytokinesis
3111:Preprophase
3055:checkpoints
2674:PDB gallery
2196:J. Cell Sci
658:nucleoplasm
441:left testis
437:bone marrow
354:37,806,959
341:37,797,409
253:29,824,312
240:29,811,991
93:Identifiers
3219:Categories
3063:Interphase
3053:Phases and
2736:Cell cycle
1918:Cancer Res
1723:Cancer Res
1366:, May 2017
1345:, May 2017
1322:References
734:cell cycle
678:centrosome
399:(ortholog)
136:HomoloGene
3186:Apoptosis
3136:Telophase
3126:Metaphase
2921:INK4a/ARF
2267:Genes Dev
1880:Genes Dev
1754:Genes Dev
1628:Genes Dev
1103:NP_031659
1056:NP_001229
1036:NM_007633
1003:NM_057182
999:NM_001238
829:Orthologs
673:cytoplasm
144:GeneCards
3131:Anaphase
3116:Prophase
2739:proteins
2478:Genomics
2378:Oncogene
2225:J. Virol
2114:38910227
2039:30799229
2002:14965268
1957:12101670
1930:11085541
1861:10581175
1825:10827081
1784:15004009
1735:12839982
1658:10500095
1609:12529437
1442:12166415
1362:–
1341:–
1311:Cyclin E
1305:See also
1242:interact
1196:Function
1151:Wikidata
808:Sources:
487:epiblast
429:testicle
425:placenta
3200:Meiosis
3107:Mitosis
3099:M phase
3080:S phase
2947:cip/kip
2636:9153308
2593:9012818
2561:Bibcode
2540:8861947
2498:8833152
2468:8756624
2425:8662825
2390:8649818
2369:8618861
2324:8617791
2289:8253383
2255:8230483
2212:8207080
2187:7739542
2144:7698009
2106:1833068
2077:1388288
2057:Bibcode
2049:Science
2031:1388095
1993:1307511
1902:8253383
1705:1388288
1685:Bibcode
1677:Science
1557:8617791
1516:9891079
1434:1833066
1364:Ensembl
1343:Ensembl
1297:SMARCA4
1213:mitotic
1183:protein
941:UniProt
896:Ensembl
835:Species
814:QuickGO
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