268:
245:
3118:
3043:
3028:
2938:
2983:
3103:
3088:
3073:
142:
167:
2998:
3013:
2953:
2878:
3058:
533:
526:
2968:
2923:
519:
2908:
2863:
2893:
274:
173:
36:
1306:
COX-1 promotes the production of the natural mucus lining that protects the inner stomach and contributes to reduced acid secretion and reduced pepsin content. COX-1 is normally present in a variety of areas of the body, including not only the stomach but any site of inflammation.
1236:(COX), is the key enzyme in prostaglandin biosynthesis. It converts free arachidonic acid, released from membrane phospholipids at the sn-2 ester binding site by the enzymatic activity of phospholipase A2, to prostaglandin (PG) H2. The reaction involves both cyclooxygenase (
1216:
was identified in the central nervous system of dogs, but does not result in a functional protein in humans. Two smaller COX-1-derived proteins (the partial COX-1 proteins PCOX-1A and PCOX-1B) have also been discovered, but their precise roles are yet to be described.
2635:
Corasaniti MT, Melino G, Navarra M, Garaci E, Finazzi-Agrò A, Nisticò G (September 1995). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase".
2415:"Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element"
2300:
Takahashi Y, Ueda N, Yoshimoto T, Yamamoto S, Yokoyama C, Miyata A, Tanabe T, Fuse I, Hattori A, Shibata A (January 1992). "Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase)".
1959:
Frömel T, Kohlstedt K, Popp R, Yin X, Awwad K, Barbosa-Sicard E, Thomas AC, Lieberz R, Mayr M, Fleming I (January 2013). "Cytochrome P4502S1: a novel monocyte/macrophage fatty acid epoxygenase in human atherosclerotic plaques".
3117:
2267:"Alternative splicing of human prostaglandin G/H synthase mRNA and evidence of differential regulation of the resulting transcripts by transforming growth factor beta 1, interleukin 1 beta, and tumor necrosis factor alpha"
3042:
3027:
2937:
2383:
Mollace V, Colasanti M, Rodino P, Lauro GM, Nistico G (August 1994). "HIV coating gp 120 glycoprotein-dependent prostaglandin E2 release by human cultured astrocytoma cells is regulated by nitric oxide formation".
2982:
3102:
3087:
3072:
2747:
Mahida YR, Beltinger J, Makh S, Göke M, Gray T, Podolsky DK, Hawkey CJ (December 1997). "Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2".
2997:
3012:
3363:
1360:
3158:
1283:)-HETE. The two 15-HETE stereoisomers have intrinsic biological activities but, perhaps more importantly, can be further metabolized to a major class of anti-inflammatory agents, the
2952:
2877:
2096:
Weitz JI (2008). "Chapter 112. Antiplatelet, Anticoagulant, and
Fibrinolytic Drugs". In Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J (eds.).
281:
180:
3057:
2967:
3356:
2125:
Richards JA, Petrel TA, Brueggemeier RW (February 2002). "Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells".
1244:) activity. The cyclooxygenase activity incorporates two oxygen molecules into arachidonic acid or alternate polyunsaturated fatty acid substrates, such as
3151:
2922:
1188:, which differ in their regulation of expression and tissue distribution. The expression of these two transcripts is differentially regulated by relevant
816:
2907:
797:
5893:
89:
3349:
1691:"Identification and absolute configuration of dihydroxy-arachidonic acids formed by oxygenation of 5S-HETE by native and aspirin-acetylated COX-2"
1740:
Serhan CN (2005). "Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution".
1462:
Yokoyama C, Tanabe T (December 1989). "Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme".
3144:
2862:
5925:
2842:
2105:
2055:
1444:
1350:
2892:
1426:
5915:
3126:: 2.0 Angstrom Crystal Structure of Manganese Protoporphyrin IX-reconstituted Ovine Prostaglandin H2 Synthase-1 Complexed With Flurbiprofen
1640:"COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression"
1316:
1327:, the major product of COX-1 in platelets, induces platelet aggregation. The inhibition of COX-1 is sufficient to explain why low dose
1064:
267:
3330:
2236:
Bingham S, Beswick PJ, Blum DE, Gray NM, Chessell IP (October 2006). "The role of the cylooxygenase pathway in nociception and pain".
3051:: PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID (IODOINDOMETHACIN), TRANS MODEL
3286:
2080:
1263:
While metabolizing arachidonic acid primarily to PGG2, COX-1 also converts this fatty acid to small amounts of a racemic mixture of
1071:
3036:: PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID (IODOINDOMETHACIN), CIS MODEL
244:
2946:: CRYSTAL STRUCTURE OF DIHOMO-GAMMA-LINOLEIC ACID BOUND IN THE CYCLOOXYGENASE CHANNEL OF PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1.
2477:
Picot D, Loll PJ, Garavito RM (January 1994). "The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1".
1624:
1300:
1288:
4339:
1875:
John H, Cammann K, Schlegel W (June 1998). "Development and review of radioimmunoassay of 12-S-hydroxyheptadecatrienoic acid".
1413:
1392:
1291:
viz.,1 2-(S)-hydroxy-5Z,8E,10E-heptadecatrienoic acid (i.e. 12-HHT) and 12-(S)-hydroxy-5Z,8Z,10E-heptadecatrienoic acid plus
1264:
1409:
2991:: Crystal Structure of Eicosapentanoic Acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.
1499:"Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment"
166:
141:
3309:
3111:: Crystal Structure of Arachidonic Acid Bound to a Mutant of Prostagladin H Synthase-1 that Forms Predominantly 11-HPETE.
3096:: 2.0 Angstrom Crystal Structure of Ovine Prostaglandin H2 Synthase-1, in complex with alpha-methyl-4-biphenylacetic acid
1388:
5886:
3254:
69:
3081:: The Structural Basis of Aspirin Activity Inferred from the Crystal Structure of Inactivated Prostaglandin H2 Synthase
2448:
Ren Y, Loose-Mitchell DS, Kulmacz RJ (February 1995). "Prostaglandin H synthase-1: evaluation of C-terminus function".
3478:
3421:
3290:
2559:"N-glycosylation of prostaglandin endoperoxide synthases-1 and -2 and their orientations in the endoplasmic reticulum"
3992:
280:
179:
3006:: Crystal Structure of Linoleic acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.
5843:
3901:
3786:
3709:
3602:
2718:
Hla T (January 1996). "Molecular characterization of the 5.2 KB isoform of the human cyclooxygenase-1 transcript".
273:
172:
3584:
3403:
3242:
2835:
1365:
1135:
4303:
2164:"Expression and cellular localization of cyclooxygenases and prostaglandin E synthases in the hemorrhagic brain"
5680:
5661:
5616:
4058:
3314:
3297:
3249:
3136:
861:
113:
77:
2207:
Jain S, Khuri FR, Shin DM (2004). "Prevention of head and neck cancer: current status and future prospects".
5920:
3386:
3304:
842:
4444:
5722:
5642:
3268:
1625:"Entrez Gene: PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)"
2003:
Laine L, Takeuchi K, Tarnawski A (2008). "Gastric mucosal defense and cytoprotection: bench to bedside".
5699:
4155:
3392:
3261:
3205:
2330:
Vane JR, Mitchell JA, Appleton I, Tomlinson A, Bishop-Bailey D, Croxtall J, Willoughby DA (March 1994).
1249:
5204:
5174:
5005:
5838:
4960:
4813:
4283:
4121:
4030:
2828:
2678:
2486:
2343:
1829:
155:
60:, COX1, COX3, PCOX1, PES-1, PGG/HS, PGHS-1, PGHS1, PHS1, PTGHS, prostaglandin-endoperoxide synthase 1
4210:
3830:
56:
5057:
5037:
4788:
4593:
4543:
1022:
1012:
1008:
1004:
1000:
951:
941:
937:
933:
929:
5363:
4828:
4718:
4713:
4698:
4633:
4583:
4538:
4103:
3021:: PROSTAGLANDIN H2 SYNTHASE-1 COMPLEXED WITH P-(2'-IODO-5'-THENOYL)HYDROTROPIC ACID (IODOSUPROFEN)
5770:
5650:
5601:
5591:
5015:
4693:
4673:
4658:
4648:
4628:
4623:
4578:
4553:
4518:
4364:
4195:
3973:
3871:
3810:
3771:
3570:
3560:
3468:
3378:
2808:
2623:
2510:
2150:
1985:
1606:
1528:
1260:, which is reduced to the corresponding alcohol, PGH2, by the enzyme's hydroperoxidase activity.
101:
5800:
5795:
5760:
5735:
5596:
5457:
5314:
4915:
4910:
4708:
4688:
4683:
4678:
4663:
4653:
4643:
4618:
4608:
4603:
4598:
4588:
4573:
4568:
4528:
4487:
4467:
4424:
4419:
4404:
4394:
4389:
4374:
4253:
4175:
4130:
4044:
4020:
4010:
3458:
1546:
Bakhle YS (1999). "Structure of COX-1 and COX-2 enzymes and their interaction with inhibitors".
1047:
1026:
996:
976:
955:
925:
5785:
5740:
5551:
5497:
5482:
5331:
5042:
4990:
4875:
4723:
4668:
4638:
4613:
4563:
4558:
4548:
4533:
4482:
4477:
4434:
4369:
4359:
4329:
4273:
4243:
4200:
4190:
4039:
3963:
3815:
3728:
3525:
2047:
1638:
Chandrasekharan NV, Dai H, Roos KL, Evanson NK, Tomsik J, Elton TS, Simmons DL (October 2002).
5790:
5765:
5755:
5606:
5581:
5566:
5531:
5507:
5502:
5253:
5184:
4853:
4823:
4703:
4523:
4457:
4429:
4414:
4409:
4384:
4000:
3968:
3948:
3891:
3776:
3699:
3694:
3689:
3684:
3520:
3515:
2800:
2765:
2735:
2706:
2653:
2615:
2580:
2545:
2502:
2465:
2436:
2401:
2371:
2318:
2288:
2253:
2224:
2195:
2142:
2101:
2076:
2051:
2020:
1977:
1941:
1892:
1857:
1798:
1757:
1722:
1671:
1598:
1563:
1520:
1479:
1292:
1184:
of COX encoded by distinct gene products: a constitutive COX-1 (this enzyme) and an inducible
1164:
Cyclooxygenase (COX) is the central enzyme in the biosynthetic pathway to prostaglandins from
532:
525:
49:
5810:
5526:
5472:
5467:
4502:
4349:
4258:
4215:
3766:
3679:
3565:
3545:
3540:
3535:
2522:
Kosaka T, Miyata A, Ihara H, Hara S, Sugimoto T, Takeda O, Takahashi E, Tanabe T (May 1994).
5866:
5858:
5853:
5672:
5576:
5571:
5157:
4743:
4379:
4344:
4234:
4220:
4180:
4113:
3939:
3930:
3862:
3853:
3845:
3747:
3738:
3660:
3651:
3502:
3440:
3193:
3171:
2961:: THE 2.75 ANGSTROM RESOLUTION MODEL OF OVINE COX-1 COMPLEXED WITH METHYL ESTER FLURBIPROFEN
2790:
2757:
2727:
2696:
2686:
2645:
2605:
2570:
2535:
2494:
2457:
2426:
2393:
2361:
2351:
2310:
2278:
2245:
2216:
2185:
2175:
2134:
2039:
2038:
Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, eds. (2008).
2012:
1969:
1931:
1923:
1884:
1847:
1837:
1788:
1749:
1712:
1702:
1661:
1651:
1590:
1555:
1510:
1471:
1340:
1253:
1169:
1165:
360:
291:
235:
190:
119:
4462:
4311:
2524:"Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2"
1818:"Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets"
1581:
Sakamoto C (October 1998). "Roles of COX-1 and COX-2 in gastrointestinal pathophysiology".
518:
97:
5714:
5646:
5556:
5231:
5209:
5179:
3876:
3200:
2220:
335:
2886:: CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND IN THE CYCLOOXYGENASE ACTIVE SITE OF PGHS-1
2682:
2490:
2347:
1833:
5236:
5189:
4754:
4316:
3375:
3223:
2667:"Interaction of cyclooxygenases with an apoptosis- and autoimmunity-associated protein"
2540:
2523:
2190:
2163:
1936:
1911:
1717:
1690:
1345:
1324:
1233:
1205:
1153:
2795:
2778:
2575:
2558:
2283:
2266:
2138:
1888:
1852:
1817:
1793:
1776:
1689:
Mulugeta S, Suzuki T, Hernandez NT, Griesser M, Boeglin WE, Schneider C (March 2010).
1666:
1639:
1475:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
660:
655:
650:
645:
640:
635:
630:
625:
620:
615:
599:
594:
589:
584:
579:
574:
5909:
5833:
5517:
5302:
5199:
5077:
5062:
4995:
4925:
2731:
2701:
2666:
2649:
2610:
2593:
2366:
2331:
2314:
2040:
1276:
1245:
1225:
1193:
561:
19:"COX-1" redirects here. For mitochondrial cytochrome c oxidase subunit 1 (cox1), see
2812:
2627:
2154:
1532:
5373:
5290:
5216:
5194:
5147:
5082:
5052:
5032:
5027:
4950:
4838:
4263:
4225:
4093:
3920:
3756:
3641:
3448:
2761:
2514:
1989:
1610:
1559:
1197:
353:
132:
3341:
2075:(11th ed.). New York: McGraw-Hill Medical Publishing Division. p. 1126.
81:
3066:: THE X-RAY CRYSTAL STRUCTURE OF THE MEMBRANE PROTEIN PROSTAGLANDIN H2 SYNTHASE-1
2249:
2016:
105:
5848:
5750:
5691:
5561:
5546:
5487:
5452:
5430:
5410:
5358:
5343:
5285:
5243:
5169:
5137:
5122:
4955:
4940:
4865:
4803:
4798:
4472:
4145:
4108:
4083:
4078:
3925:
3881:
3840:
3835:
3733:
3669:
3646:
3636:
3555:
3530:
3497:
3463:
3278:
2332:"Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation"
1753:
1449:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1431:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1237:
1209:
1201:
2671:
Proceedings of the
National Academy of Sciences of the United States of America
2594:"Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues"
2336:
Proceedings of the
National Academy of Sciences of the United States of America
1912:"Human CYP2S1 metabolizes cyclooxygenase- and lipoxygenase-derived eicosanoids"
1822:
Proceedings of the
National Academy of Sciences of the United States of America
1644:
Proceedings of the
National Academy of Sciences of the United States of America
1515:
1498:
436:
5780:
5541:
5512:
5492:
5445:
5440:
5425:
5400:
5368:
5336:
5307:
5263:
5162:
5112:
5107:
5102:
5097:
5072:
4985:
4980:
4920:
4905:
4885:
4870:
4843:
4818:
4808:
4793:
4783:
4497:
4452:
4439:
4354:
4140:
4135:
4088:
4025:
4005:
3958:
3550:
3372:
3215:
3175:
3167:
1973:
1241:
252:
149:
85:
2431:
2414:
5805:
5745:
5477:
5435:
5420:
5415:
5405:
5395:
5390:
5385:
5380:
5295:
5278:
5273:
5268:
5152:
5132:
5127:
5092:
5087:
5047:
5020:
4975:
4970:
4965:
4945:
4900:
4895:
4858:
4848:
4773:
4492:
4399:
4248:
4185:
4098:
4015:
3820:
3805:
3626:
3621:
2976:: THE 2.7 ANGSTROM RESOLUTION MODEL OF OVINE COX-1 COMPLEXED WITH ALCLOFENAC
2691:
761:
496:
374:
319:
306:
218:
205:
93:
2461:
2397:
2356:
2257:
2228:
2199:
2180:
2146:
2024:
1981:
1945:
1927:
1842:
1761:
1726:
1675:
1656:
1567:
2804:
2769:
2739:
2710:
2657:
2619:
2584:
2549:
2506:
2469:
2440:
2405:
2375:
2322:
2292:
1910:
Bui P, Imaizumi S, Beedanagari SR, Reddy ST, Hankinson O (February 2011).
1896:
1861:
1802:
1602:
1594:
1524:
1483:
1303:). These alternate metabolites of COX-1 may contribute to its activities.
1111:
1106:
5638:
5633:
5462:
5324:
5319:
5258:
5248:
5226:
5221:
5142:
5117:
5067:
5010:
5000:
4935:
4930:
4890:
4205:
3825:
3631:
1287:. In addition, PGG2 and PGH2 rearrange non-enzymatically to a mixture of
1284:
1229:
1189:
1181:
1095:
906:
887:
1707:
5775:
5586:
5353:
4880:
4833:
4778:
4324:
1328:
1320:
873:
828:
2777:
Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN (May 1998).
5536:
4737:
3179:
2779:"Cyclooxygenase regulates angiogenesis induced by colon cancer cells"
2498:
1296:
1142:
1079:
783:
20:
2665:
Ballif BA, Mincek NV, Barratt JT, Wilson ML, Simmons DL (May 1996).
2931:: THE 2.7 ANGSTROM MODEL OF OVINE COX-1 COMPLEXED WITH FLURBIPROFEN
5348:
3233:
3228:
1497:
Funk CD, Funk LB, Kennedy ME, Pong AS, Fitzgerald GA (June 1991).
1355:
1213:
1185:
746:
742:
2916:: THE 2.6 ANGSTROM MODEL OF OVINE COX-1 COMPLEXED WITH IBUPROFEN
2073:
1257:
1149:
73:
35:
3345:
3140:
2824:
1777:"On the organization and mechanism of prostaglandin synthetase"
541:
2820:
2413:
Inoue H, Yokoyama C, Hara S, Tone Y, Tanabe T (October 1995).
2127:
The
Journal of Steroid Biochemistry and Molecular Biology
2046:(17th ed.). New York: McGraw-Hill Medical. p.
343:
2871:: PROSTAGLANDIN H2 SYNTHASE-1 COMPLEX WITH FLURBIPROFEN
1742:
Prostaglandins, Leukotrienes, and
Essential Fatty Acids
1361:
Discovery and development of COX-2 selective inhibitors
1168:. This protein was isolated more than 40 years ago and
2901:: OVINE PGHS-1 COMPLEXED WITH SALICYL HYDROXAMIC ACID
508:
5823:
5721:
5698:
5679:
5660:
5615:
4753:
4736:
4511:
4282:
4154:
4057:
3982:
3900:
3785:
3708:
3601:
3583:
3479:
3477:
3422:
3420:
3402:
3385:
3323:
3277:
3214:
3186:
2386:
Biochemical and Biophysical Research Communications
2303:
Biochemical and Biophysical Research Communications
1464:
Biochemical and Biophysical Research Communications
1040:
995:
969:
924:
4760:
3902:
3787:
3710:
3603:
1405:
1403:
1401:
1384:
1382:
1380:
3585:
3404:
2592:O'Neill GP, Ford-Hutchinson AW (September 1993).
290:
189:
5681:
5662:
5617:
4059:
2100:(17th ed.). New York: McGraw-Hill Medical.
5723:
1410:GRCm38: Ensembl release 89: ENSMUSG00000047250
5700:
4156:
3357:
3152:
2836:
8:
4284:
2557:Otto JC, DeWitt DL, Smith WL (August 1993).
2265:Diaz A, Reginato AM, Jimenez SA (May 1992).
2238:Seminars in Cell & Developmental Biology
580:prostaglandin-endoperoxide synthase activity
1389:GRCh38: Ensembl release 89: ENSG00000095303
1196:. This gene encodes COX-1, which regulates
692:regulation of cell population proliferation
4750:
3598:
3417:
3399:
3364:
3350:
3342:
3159:
3145:
3137:
2843:
2829:
2821:
2098:Harrison's Principles of Internal Medicine
2042:Harrison's Principles of Internal Medicine
1877:Prostaglandins & Other Lipid Mediators
1816:Hamberg M, Samuelsson B (September 1974).
992:
921:
757:
557:
471:transitional epithelium of urinary bladder
331:
230:
127:
2794:
2700:
2690:
2609:
2574:
2539:
2430:
2365:
2355:
2282:
2189:
2179:
1935:
1851:
1841:
1792:
1716:
1706:
1665:
1655:
1514:
1331:is effective at reducing cardiac events.
1775:Wlodawer P, Samuelsson B (August 1973).
621:intracellular membrane-bounded organelle
2858:
2450:Archives of Biochemistry and Biophysics
2071:Parker KL, Brunton LL, Lazo JS (2005).
1376:
4755:
1256:forms a labile intermediate peroxide,
25:
2221:10.1016/j.currproblcancer.2004.05.003
1267:(i.e., 15-HETEs) composed of ~22% 15(
1132:prostaglandin-endoperoxide synthase 1
295:
256:
251:
194:
153:
148:
7:
5378:Selective COX-2 inhibitors (coxibs):
1317:nonsteroidal anti-inflammatory drugs
3487:Tooltip Prostaglandin D2 receptor 2
3430:Tooltip Prostaglandin D2 receptor 1
2563:The Journal of Biological Chemistry
2419:The Journal of Biological Chemistry
2271:The Journal of Biological Chemistry
2162:Wu T, Wu H, Wang J, Wang J (2011).
1781:The Journal of Biological Chemistry
1212:. A splice variant of COX-1 termed
5349:AM-404 (N-arachidonoylaminophenol)
5167:Anthranilic acids (fenamic acids):
4819:Mesalazine (5-aminosalicylic acid)
3910:Tooltip Prostaglandin EP4 receptor
3795:Tooltip Prostaglandin EP3 receptor
3718:Tooltip Prostaglandin EP2 receptor
3611:Tooltip Prostaglandin EP1 receptor
2750:The American Journal of Physiology
2541:10.1111/j.1432-1033.1994.tb18804.x
1037:
966:
897:
878:
852:
833:
807:
788:
677:prostaglandin biosynthetic process
513:
431:
369:
348:
14:
5839:γ-Linolenic acid (gamolenic acid)
5185:Meclofenamic acid (meclofenamate)
3594:Tooltip Prostaglandin E2 receptor
3413:Tooltip Prostaglandin D2 receptor
3287:5-Lipoxygenase activating protein
1289:12-Hydroxyheptadecatrienoic acids
1204:cells. COX-1 is also involved in
1145:that in humans is encoded by the
5894:Leukotriene signaling modulators
5686:Tooltip Prostaglandin F synthase
5667:Tooltip Prostaglandin E synthase
5626:Tooltip Prostaglandin D synthase
4068:Tooltip Prostaglandin F receptor
3116:
3101:
3086:
3071:
3056:
3041:
3026:
3011:
2996:
2981:
2966:
2951:
2936:
2921:
2906:
2891:
2876:
2861:
2528:European Journal of Biochemistry
1301:12-Hydroxyheptadecatrienoic acid
1279:as well as a small amount of 11(
531:
524:
517:
279:
272:
266:
243:
178:
171:
165:
140:
34:
5205:Talinflumic acid (talinflumate)
5195:Morniflumic acid (morniflumate)
5175:Floctafenic acid (floctafenate)
5158:Tiaprofenic acid (tiaprofenate)
1916:Drug Metabolism and Disposition
1265:15-Hydroxyicosatetraenoic acids
732:cellular oxidant detoxification
697:prostaglandin metabolic process
682:fatty acid biosynthetic process
5728:Tooltip Thromboxane A synthase
4779:Aspirin (acetylsalicylic acid)
3993:16,16-Dimethyl Prostaglandin E
2762:10.1152/ajpgi.1997.273.6.G1341
1560:10.1358/dot.1999.35.4-5.552200
661:endoplasmic reticulum membrane
542:More reference expression data
497:More reference expression data
1:
5887:Receptor/signaling modulators
5709:Tooltip Prostacyclin synthase
5210:Tolfenamic acid (tolfenamate)
5180:Flufenamic acid (flufenamate)
5170:Etofenamic acid (etofenamate)
4226:Prostacyclin (prostaglandin I
4165:Tooltip Prostacyclin receptor
3310:Gamma-glutamyl transpeptidase
3298:LTA4 hydrolase (B4 synthesis)
2796:10.1016/S0092-8674(00)81433-6
2576:10.1016/S0021-9258(17)46835-9
2284:10.1016/S0021-9258(19)50092-8
2139:10.1016/S0960-0760(01)00187-X
1889:10.1016/s0090-6980(98)00043-4
1794:10.1016/S0021-9258(19)43558-8
1476:10.1016/S0006-291X(89)80049-X
1152:. In humans it is one of two
405:muscle layer of sigmoid colon
264:
163:
5926:Peripheral membrane proteins
4293:Tooltip Thromboxane receptor
3255:Prostaglandin-E2 9-reductase
2732:10.1016/0090-6980(95)00158-1
2650:10.1016/1055-8330(95)90021-7
2611:10.1016/0014-5793(93)80263-T
2315:10.1016/0006-291X(92)91750-K
2250:10.1016/j.semcdb.2006.09.001
2168:Journal of Neuroinflammation
2017:10.1053/j.gastro.2008.05.030
1962:Basic Research in Cardiology
1295:. and can be metabolized by
727:fatty acid metabolic process
722:xenobiotic metabolic process
702:regulation of blood pressure
687:response to oxidative stress
5916:Genes on human chromosome 9
5359:Paracetamol (acetaminophen)
5190:Mefenamic acid (mefenamate)
4844:Salicylate (salicylic acid)
3291:Arachidonate 5-lipoxygenase
1754:10.1016/j.plefa.2005.05.002
1583:Journal of Gastroenterology
626:photoreceptor outer segment
385:stromal cell of endometrium
5942:
5038:Bucloxic acid (blucloxate)
4956:Indometacin (indomethacin)
2209:Current Problems in Cancer
1516:10.1096/fasebj.5.9.1907252
18:
5878:
5200:Niflumic acid (niflumate)
4304:Carbocyclic thromboxane A
2856:
1974:10.1007/s00395-012-0319-8
1695:Journal of Lipid Research
1445:"Mouse PubMed Reference:"
1427:"Human PubMed Reference:"
1366:COX-2 selective inhibitor
1110:
1105:
1101:
1094:
1078:
1059:
1044:
1019:
988:
973:
948:
917:
904:
900:
885:
881:
872:
859:
855:
840:
836:
827:
814:
810:
795:
791:
782:
767:
760:
756:
740:
560:
556:
539:
516:
507:
494:
447:medullary collecting duct
443:
434:
381:
372:
342:
334:
330:
313:
300:
263:
242:
233:
229:
212:
199:
162:
139:
130:
126:
117:
112:
67:
64:
54:
47:
42:
33:
28:
5518:Menatetrenone (vitamin K
5341:Aminophenols (anilines):
2432:10.1074/jbc.270.42.24965
1065:Chr 9: 122.37 – 122.4 Mb
413:tendon of biceps brachii
5844:Dihomo-γ-linolenic acid
5241:Enolic acids (oxicams):
4784:Benorilate (benorylate)
2692:10.1073/pnas.93.11.5544
1240:) and hydroperoxidase (
1208:and maintaining tissue
1072:Chr 2: 36.12 – 36.14 Mb
575:oxidoreductase activity
5643:selenium tetrachloride
2462:10.1006/abbi.1995.1100
2398:10.1006/bbrc.1994.2152
2357:10.1073/pnas.91.6.2046
2181:10.1186/1742-2094-8-22
1928:10.1124/dmd.110.035121
1843:10.1073/pnas.71.9.3400
1657:10.1073/pnas.162468699
1315:COX-1 is inhibited by
1232:(PTGS), also known as
707:cyclooxygenase pathway
5312:Aminonicotinic acids:
3206:Diacylglycerol lipase
1595:10.1007/s005350050147
1311:Clinical significance
1250:eicosapentaenoic acid
717:inflammatory response
646:endoplasmic reticulum
636:extracellular exosome
4961:Indometacin farnesil
4814:Magnesium salicylate
4445:Pinane thromboxane A
4206:Iloprost (ciloprost)
3826:Iloprost (ciloprost)
3632:Iloprost (ciloprost)
585:dioxygenase activity
451:skin of external ear
258:Chromosome 2 (mouse)
156:Chromosome 9 (human)
4789:Carbasalate calcium
2756:(6 Pt 1): G1341-8.
2683:1996PNAS...93.5544B
2491:1994Natur.367..243P
2348:1994PNAS...91.2046V
1834:1974PNAS...71.3400H
1708:10.1194/jlr.M001719
1271:)-HETE and ~78% 15(
600:peroxidase activity
479:conjunctival fornix
475:right lobe of liver
389:germinal epithelium
297:2 B|2 24.19 cM
5651:selenium disulfide
5283:4-Aminoquinolines:
862:ENSMUSG00000047250
670:Biological process
631:organelle membrane
609:Cellular component
568:Molecular function
467:tibiofemoral joint
5903:
5902:
5819:
5818:
4854:Sodium salicylate
4824:Methyl salicylate
4747:
4732:
4731:
4053:
4052:
3579:
3578:
3396:
3339:
3338:
3134:
3133:
2638:Neurodegeneration
2107:978-0-07-146633-2
2057:978-0-07-146633-2
1319:(NSAIDs) such as
1293:Malonyldialdehyde
1176:Gene and isozymes
1130:), also known as
1121:
1120:
1117:
1116:
1090:
1089:
1055:
1054:
1034:
1033:
984:
983:
963:
962:
913:
912:
894:
893:
868:
867:
849:
848:
823:
822:
804:
803:
752:
751:
595:metal ion binding
552:
551:
548:
547:
503:
502:
490:
489:
428:
427:
326:
325:
225:
224:
106:PTGS1 - orthologs
5933:
5854:Arachidonic acid
5729:
5725:
5710:
5706:
5687:
5683:
5668:
5664:
5627:
5623:
5450:Others/unsorted:
5025:Propionic acids:
5006:Sulindac sulfide
4771:Salicylic acids:
4762:
4757:
4751:
4741:
4294:
4290:
4166:
4162:
4069:
4065:
3911:
3907:
3796:
3792:
3719:
3715:
3612:
3608:
3599:
3595:
3591:
3488:
3484:
3431:
3427:
3418:
3414:
3410:
3400:
3390:
3366:
3359:
3352:
3343:
3194:Phospholipase A2
3172:lipid metabolism
3161:
3154:
3147:
3138:
3120:
3105:
3090:
3075:
3060:
3045:
3030:
3015:
3000:
2985:
2970:
2955:
2940:
2925:
2910:
2895:
2880:
2865:
2845:
2838:
2831:
2822:
2816:
2798:
2773:
2743:
2714:
2704:
2694:
2661:
2631:
2613:
2588:
2578:
2569:(24): 18234–42.
2553:
2543:
2518:
2499:10.1038/367243a0
2473:
2444:
2434:
2425:(42): 24965–71.
2409:
2379:
2369:
2359:
2326:
2296:
2286:
2277:(15): 10816–22.
2261:
2232:
2203:
2193:
2183:
2158:
2112:
2111:
2093:
2087:
2086:
2068:
2062:
2061:
2045:
2035:
2029:
2028:
2005:Gastroenterology
2000:
1994:
1993:
1956:
1950:
1949:
1939:
1907:
1901:
1900:
1872:
1866:
1865:
1855:
1845:
1813:
1807:
1806:
1796:
1772:
1766:
1765:
1737:
1731:
1730:
1720:
1710:
1686:
1680:
1679:
1669:
1659:
1650:(21): 13926–31.
1635:
1629:
1628:
1621:
1615:
1614:
1578:
1572:
1571:
1543:
1537:
1536:
1518:
1494:
1488:
1487:
1459:
1453:
1452:
1441:
1435:
1434:
1423:
1417:
1407:
1396:
1386:
1351:Cyclooxygenase 2
1341:Arachidonic acid
1254:arachidonic acid
1252:. Metabolism of
1166:arachidonic acid
1124:Cyclooxygenase 1
1103:
1102:
1074:
1067:
1050:
1038:
1029:
993:
989:RefSeq (protein)
979:
967:
958:
922:
898:
879:
853:
834:
808:
789:
758:
712:lipid metabolism
558:
544:
535:
528:
521:
514:
499:
439:
437:Top expressed in
432:
377:
375:Top expressed in
370:
349:
332:
322:
309:
298:
283:
276:
270:
259:
247:
231:
221:
208:
197:
182:
175:
169:
158:
144:
128:
122:
108:
59:
52:
38:
26:
5941:
5940:
5936:
5935:
5934:
5932:
5931:
5930:
5906:
5905:
5904:
5899:
5874:
5870:
5867:Prostaglandin H
5862:
5859:Prostaglandin G
5815:
5727:
5717:
5715:Tranylcypromine
5708:
5704:
5694:
5685:
5675:
5666:
5656:
5647:sodium selenite
5625:
5621:
5611:
5557:Rosmarinic acid
5521:
5329:Sulfonanilides:
5232:Oxyphenbutazone
4758:
4740:
4728:
4507:
4448:
4320:
4307:
4292:
4288:
4278:
4238:
4235:Prostaglandin E
4230:, epoprostenol)
4229:
4164:
4160:
4150:
4125:
4122:Prostaglandin F
4117:
4114:Prostaglandin D
4067:
4063:
4049:
4034:
4031:Prostaglandin F
3996:
3978:
3943:
3940:Prostaglandin E
3934:
3931:Prostaglandin E
3909:
3906:
3896:
3877:Ricinoleic acid
3866:
3863:Prostaglandin E
3857:
3854:Prostaglandin E
3849:
3846:Prostaglandin D
3794:
3791:
3781:
3751:
3748:Prostaglandin E
3742:
3739:Prostaglandin E
3717:
3714:
3704:
3664:
3661:Prostaglandin E
3655:
3652:Prostaglandin E
3610:
3607:
3593:
3589:
3575:
3506:
3503:Prostaglandin D
3486:
3483:
3473:
3444:
3441:Prostaglandin D
3429:
3426:
3412:
3408:
3389:
3381:
3370:
3340:
3335:
3319:
3273:
3210:
3201:Phospholipase C
3182:
3165:
3135:
3130:
3127:
3121:
3112:
3106:
3097:
3091:
3082:
3076:
3067:
3061:
3052:
3046:
3037:
3031:
3022:
3016:
3007:
3001:
2992:
2986:
2977:
2971:
2962:
2956:
2947:
2941:
2932:
2926:
2917:
2911:
2902:
2896:
2887:
2881:
2872:
2866:
2852:
2849:
2819:
2776:
2746:
2717:
2664:
2634:
2591:
2556:
2521:
2485:(6460): 243–9.
2476:
2447:
2412:
2382:
2329:
2299:
2264:
2235:
2206:
2161:
2124:
2120:
2118:Further reading
2115:
2108:
2095:
2094:
2090:
2083:
2070:
2069:
2065:
2058:
2037:
2036:
2032:
2002:
2001:
1997:
1958:
1957:
1953:
1909:
1908:
1904:
1874:
1873:
1869:
1815:
1814:
1810:
1774:
1773:
1769:
1748:(3–4): 141–62.
1739:
1738:
1734:
1688:
1687:
1683:
1637:
1636:
1632:
1623:
1622:
1618:
1580:
1579:
1575:
1554:(4–5): 237–50.
1545:
1544:
1540:
1496:
1495:
1491:
1461:
1460:
1456:
1443:
1442:
1438:
1425:
1424:
1420:
1408:
1399:
1387:
1378:
1374:
1337:
1313:
1299:to 12-HHT (see
1223:
1178:
1162:
1154:cyclooxygenases
1112:View/Edit Mouse
1107:View/Edit Human
1070:
1063:
1060:Location (UCSC)
1046:
1025:
1021:
1015:
1011:
1007:
1003:
999:
975:
954:
950:
944:
940:
936:
932:
928:
843:ENSG00000095303
736:
665:
656:Golgi apparatus
604:
540:
530:
529:
523:
522:
495:
486:
481:
477:
473:
469:
465:
463:right lung lobe
461:
457:
453:
449:
435:
424:
421:urinary bladder
419:
417:skin of abdomen
415:
411:
409:parietal pleura
407:
403:
399:
395:
391:
387:
373:
317:
304:
296:
286:
285:
284:
277:
257:
234:Gene location (
216:
203:
195:
185:
184:
183:
176:
154:
131:Gene location (
118:
68:
55:
48:
24:
17:
12:
11:
5:
5939:
5937:
5929:
5928:
5923:
5921:Prostaglandins
5918:
5908:
5907:
5901:
5900:
5898:
5897:
5890:
5883:
5879:
5876:
5875:
5873:
5872:
5868:
5864:
5860:
5856:
5851:
5849:Diacylglycerol
5846:
5841:
5836:
5827:
5825:
5821:
5820:
5817:
5816:
5814:
5813:
5808:
5803:
5798:
5793:
5788:
5783:
5778:
5773:
5768:
5763:
5758:
5753:
5748:
5743:
5738:
5732:
5730:
5719:
5718:
5713:
5711:
5702:
5696:
5695:
5690:
5688:
5677:
5676:
5671:
5669:
5658:
5657:
5655:
5654:
5636:
5630:
5628:
5619:
5613:
5612:
5610:
5609:
5604:
5599:
5594:
5589:
5584:
5579:
5574:
5569:
5564:
5559:
5554:
5549:
5544:
5539:
5534:
5529:
5524:
5519:
5515:
5510:
5505:
5500:
5495:
5490:
5485:
5480:
5475:
5470:
5465:
5460:
5455:
5443:
5438:
5433:
5428:
5423:
5418:
5413:
5408:
5403:
5398:
5393:
5388:
5383:
5371:
5366:
5361:
5356:
5351:
5346:
5334:
5322:
5317:
5305:
5293:
5288:
5276:
5271:
5266:
5261:
5256:
5251:
5246:
5237:Phenylbutazone
5234:
5229:
5224:
5219:
5207:
5202:
5197:
5192:
5187:
5182:
5177:
5172:
5160:
5155:
5150:
5145:
5140:
5135:
5130:
5125:
5120:
5115:
5110:
5105:
5100:
5095:
5090:
5085:
5080:
5075:
5070:
5065:
5060:
5055:
5050:
5045:
5040:
5035:
5030:
5018:
5013:
5008:
5003:
4998:
4993:
4988:
4983:
4978:
4973:
4968:
4963:
4958:
4953:
4948:
4943:
4938:
4933:
4928:
4923:
4918:
4913:
4908:
4903:
4898:
4893:
4888:
4883:
4878:
4873:
4868:
4856:
4851:
4846:
4841:
4836:
4831:
4826:
4821:
4816:
4811:
4806:
4801:
4796:
4791:
4786:
4781:
4776:
4767:
4765:
4748:
4734:
4733:
4730:
4729:
4727:
4726:
4721:
4716:
4711:
4706:
4701:
4696:
4691:
4686:
4681:
4676:
4671:
4666:
4661:
4656:
4651:
4646:
4641:
4636:
4631:
4626:
4621:
4616:
4611:
4606:
4601:
4596:
4591:
4586:
4581:
4576:
4571:
4566:
4561:
4556:
4551:
4546:
4541:
4536:
4531:
4526:
4521:
4515:
4513:
4509:
4508:
4506:
4505:
4500:
4495:
4490:
4485:
4480:
4475:
4470:
4465:
4460:
4455:
4450:
4446:
4442:
4437:
4432:
4427:
4422:
4417:
4412:
4407:
4402:
4397:
4392:
4387:
4382:
4377:
4372:
4367:
4362:
4357:
4352:
4347:
4342:
4333:
4332:
4327:
4322:
4318:
4314:
4309:
4305:
4297:
4295:
4286:
4280:
4279:
4277:
4276:
4267:
4266:
4261:
4256:
4251:
4246:
4241:
4236:
4232:
4227:
4223:
4218:
4213:
4211:Isocarbacyclin
4208:
4203:
4198:
4193:
4188:
4183:
4178:
4169:
4167:
4158:
4152:
4151:
4149:
4148:
4143:
4138:
4133:
4128:
4123:
4119:
4115:
4111:
4106:
4101:
4096:
4091:
4086:
4081:
4072:
4070:
4061:
4055:
4054:
4051:
4050:
4048:
4047:
4042:
4037:
4032:
4028:
4023:
4018:
4013:
4008:
4003:
3998:
3994:
3986:
3984:
3980:
3979:
3977:
3976:
3971:
3966:
3961:
3952:
3951:
3946:
3944:(dinoprostone)
3941:
3937:
3932:
3928:
3923:
3914:
3912:
3904:
3898:
3897:
3895:
3894:
3885:
3884:
3879:
3874:
3869:
3867:(dinoprostone)
3864:
3860:
3855:
3851:
3847:
3843:
3838:
3833:
3831:Isocarbacyclin
3828:
3823:
3818:
3813:
3808:
3799:
3797:
3789:
3783:
3782:
3780:
3779:
3774:
3769:
3760:
3759:
3754:
3752:(dinoprostone)
3749:
3745:
3740:
3736:
3731:
3722:
3720:
3712:
3706:
3705:
3703:
3702:
3697:
3692:
3687:
3682:
3673:
3672:
3667:
3665:(dinoprostone)
3662:
3658:
3653:
3649:
3644:
3639:
3634:
3629:
3624:
3615:
3613:
3605:
3596:
3587:
3581:
3580:
3577:
3576:
3574:
3573:
3568:
3563:
3558:
3553:
3548:
3543:
3538:
3533:
3528:
3523:
3518:
3509:
3508:
3504:
3500:
3491:
3489:
3481:
3475:
3474:
3472:
3471:
3466:
3461:
3452:
3451:
3446:
3442:
3434:
3432:
3424:
3415:
3406:
3397:
3383:
3382:
3371:
3369:
3368:
3361:
3354:
3346:
3337:
3336:
3334:
3333:
3327:
3325:
3321:
3320:
3318:
3317:
3315:LTD4 hydrolase
3312:
3307:
3301:
3300:
3294:
3293:
3283:
3281:
3275:
3274:
3272:
3271:
3265:
3264:
3258:
3257:
3252:
3246:
3245:
3239:
3238:
3237:
3236:
3231:
3224:Cyclooxygenase
3220:
3218:
3212:
3211:
3209:
3208:
3203:
3197:
3196:
3190:
3188:
3184:
3183:
3166:
3164:
3163:
3156:
3149:
3141:
3132:
3131:
3129:
3128:
3122:
3115:
3113:
3107:
3100:
3098:
3092:
3085:
3083:
3077:
3070:
3068:
3062:
3055:
3053:
3047:
3040:
3038:
3032:
3025:
3023:
3017:
3010:
3008:
3002:
2995:
2993:
2987:
2980:
2978:
2972:
2965:
2963:
2957:
2950:
2948:
2942:
2935:
2933:
2927:
2920:
2918:
2912:
2905:
2903:
2897:
2890:
2888:
2882:
2875:
2873:
2867:
2860:
2857:
2854:
2853:
2850:
2848:
2847:
2840:
2833:
2825:
2818:
2817:
2774:
2744:
2720:Prostaglandins
2715:
2677:(11): 5544–9.
2662:
2632:
2589:
2554:
2519:
2474:
2445:
2410:
2380:
2342:(6): 2046–50.
2327:
2297:
2262:
2233:
2204:
2159:
2121:
2119:
2116:
2114:
2113:
2106:
2088:
2081:
2063:
2056:
2030:
1995:
1951:
1902:
1883:(2–3): 53–76.
1867:
1808:
1787:(16): 5673–8.
1767:
1732:
1681:
1630:
1616:
1573:
1548:Drugs of Today
1538:
1509:(9): 2304–12.
1489:
1454:
1436:
1418:
1397:
1375:
1373:
1370:
1369:
1368:
1363:
1358:
1353:
1348:
1346:Cyclooxygenase
1343:
1336:
1333:
1325:Thromboxane A2
1312:
1309:
1234:cyclooxygenase
1228:-endoperoxide
1222:
1219:
1206:cell signaling
1194:growth factors
1180:There are two
1177:
1174:
1161:
1158:
1119:
1118:
1115:
1114:
1109:
1099:
1098:
1092:
1091:
1088:
1087:
1085:
1083:
1076:
1075:
1068:
1061:
1057:
1056:
1053:
1052:
1042:
1041:
1035:
1032:
1031:
1017:
1016:
990:
986:
985:
982:
981:
971:
970:
964:
961:
960:
946:
945:
919:
915:
914:
911:
910:
902:
901:
895:
892:
891:
883:
882:
876:
870:
869:
866:
865:
857:
856:
850:
847:
846:
838:
837:
831:
825:
824:
821:
820:
812:
811:
805:
802:
801:
793:
792:
786:
780:
779:
774:
769:
765:
764:
754:
753:
750:
749:
738:
737:
735:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
673:
671:
667:
666:
664:
663:
658:
653:
648:
643:
638:
633:
628:
623:
618:
612:
610:
606:
605:
603:
602:
597:
592:
587:
582:
577:
571:
569:
565:
564:
554:
553:
550:
549:
546:
545:
537:
536:
511:
505:
504:
501:
500:
492:
491:
488:
487:
485:
484:
480:
476:
472:
468:
464:
460:
459:left lung lobe
456:
452:
448:
444:
441:
440:
429:
426:
425:
423:
422:
418:
414:
410:
406:
402:
398:
394:
390:
386:
382:
379:
378:
366:
365:
357:
346:
340:
339:
336:RNA expression
328:
327:
324:
323:
315:
311:
310:
302:
299:
294:
288:
287:
278:
271:
265:
261:
260:
255:
249:
248:
240:
239:
227:
226:
223:
222:
214:
210:
209:
201:
198:
193:
187:
186:
177:
170:
164:
160:
159:
152:
146:
145:
137:
136:
124:
123:
116:
110:
109:
66:
62:
61:
53:
45:
44:
40:
39:
31:
30:
15:
13:
10:
9:
6:
4:
3:
2:
5938:
5927:
5924:
5922:
5919:
5917:
5914:
5913:
5911:
5896:
5895:
5891:
5889:
5888:
5884:
5881:
5880:
5877:
5871:
5865:
5863:
5857:
5855:
5852:
5850:
5847:
5845:
5842:
5840:
5837:
5835:
5834:Linoleic acid
5832:
5829:
5828:
5826:
5822:
5812:
5809:
5807:
5804:
5802:
5799:
5797:
5794:
5792:
5789:
5787:
5784:
5782:
5779:
5777:
5774:
5772:
5769:
5767:
5764:
5762:
5759:
5757:
5754:
5752:
5749:
5747:
5744:
5742:
5739:
5737:
5734:
5733:
5731:
5726:
5720:
5716:
5712:
5707:
5697:
5693:
5689:
5684:
5678:
5674:
5670:
5665:
5659:
5652:
5648:
5644:
5640:
5637:
5635:
5632:
5631:
5629:
5624:
5614:
5608:
5605:
5603:
5600:
5598:
5595:
5593:
5590:
5588:
5585:
5583:
5580:
5578:
5575:
5573:
5570:
5568:
5565:
5563:
5560:
5558:
5555:
5553:
5550:
5548:
5545:
5543:
5540:
5538:
5535:
5533:
5530:
5528:
5525:
5523:
5516:
5514:
5511:
5509:
5506:
5504:
5501:
5499:
5496:
5494:
5491:
5489:
5486:
5484:
5481:
5479:
5476:
5474:
5471:
5469:
5466:
5464:
5461:
5459:
5456:
5454:
5451:
5447:
5444:
5442:
5439:
5437:
5434:
5432:
5429:
5427:
5424:
5422:
5419:
5417:
5414:
5412:
5409:
5407:
5404:
5402:
5399:
5397:
5394:
5392:
5389:
5387:
5384:
5382:
5379:
5375:
5372:
5370:
5367:
5365:
5362:
5360:
5357:
5355:
5352:
5350:
5347:
5345:
5342:
5338:
5335:
5333:
5330:
5326:
5323:
5321:
5318:
5316:
5313:
5309:
5306:
5304:
5303:Fluproquazone
5301:
5300:Quinazolines:
5297:
5294:
5292:
5289:
5287:
5284:
5280:
5277:
5275:
5272:
5270:
5267:
5265:
5262:
5260:
5257:
5255:
5252:
5250:
5247:
5245:
5242:
5238:
5235:
5233:
5230:
5228:
5225:
5223:
5220:
5218:
5215:
5211:
5208:
5206:
5203:
5201:
5198:
5196:
5193:
5191:
5188:
5186:
5183:
5181:
5178:
5176:
5173:
5171:
5168:
5164:
5161:
5159:
5156:
5154:
5151:
5149:
5146:
5144:
5141:
5139:
5136:
5134:
5131:
5129:
5126:
5124:
5121:
5119:
5116:
5114:
5111:
5109:
5106:
5104:
5101:
5099:
5096:
5094:
5091:
5089:
5086:
5084:
5081:
5079:
5078:Flunoxaprofen
5076:
5074:
5071:
5069:
5066:
5064:
5063:Dexketoprofen
5061:
5059:
5058:Dexindoprofen
5056:
5054:
5051:
5049:
5046:
5044:
5041:
5039:
5036:
5034:
5031:
5029:
5026:
5022:
5019:
5017:
5014:
5012:
5009:
5007:
5004:
5002:
4999:
4997:
4996:Proglumetacin
4994:
4992:
4989:
4987:
4984:
4982:
4979:
4977:
4974:
4972:
4969:
4967:
4964:
4962:
4959:
4957:
4954:
4952:
4949:
4947:
4944:
4942:
4939:
4937:
4934:
4932:
4929:
4927:
4926:Difenpiramide
4924:
4922:
4919:
4917:
4914:
4912:
4909:
4907:
4904:
4902:
4899:
4897:
4894:
4892:
4889:
4887:
4884:
4882:
4879:
4877:
4874:
4872:
4869:
4867:
4864:
4863:Acetic acids:
4860:
4857:
4855:
4852:
4850:
4847:
4845:
4842:
4840:
4837:
4835:
4832:
4830:
4827:
4825:
4822:
4820:
4817:
4815:
4812:
4810:
4807:
4805:
4802:
4800:
4797:
4795:
4792:
4790:
4787:
4785:
4782:
4780:
4777:
4775:
4772:
4769:
4768:
4766:
4764:
4752:
4749:
4745:
4739:
4735:
4725:
4722:
4720:
4717:
4715:
4712:
4710:
4707:
4705:
4702:
4700:
4697:
4695:
4692:
4690:
4687:
4685:
4682:
4680:
4677:
4675:
4672:
4670:
4667:
4665:
4662:
4660:
4657:
4655:
4652:
4650:
4647:
4645:
4642:
4640:
4637:
4635:
4632:
4630:
4627:
4625:
4622:
4620:
4617:
4615:
4612:
4610:
4607:
4605:
4602:
4600:
4597:
4595:
4594:Fenprostalene
4592:
4590:
4587:
4585:
4582:
4580:
4577:
4575:
4572:
4570:
4567:
4565:
4562:
4560:
4557:
4555:
4552:
4550:
4547:
4545:
4544:Delprostenate
4542:
4540:
4537:
4535:
4532:
4530:
4527:
4525:
4522:
4520:
4517:
4516:
4514:
4510:
4504:
4501:
4499:
4496:
4494:
4491:
4489:
4486:
4484:
4481:
4479:
4476:
4474:
4471:
4469:
4466:
4464:
4461:
4459:
4456:
4454:
4451:
4449:
4443:
4441:
4438:
4436:
4433:
4431:
4428:
4426:
4423:
4421:
4418:
4416:
4413:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4388:
4386:
4383:
4381:
4378:
4376:
4373:
4371:
4368:
4366:
4363:
4361:
4358:
4356:
4353:
4351:
4348:
4346:
4343:
4341:
4338:
4335:
4334:
4331:
4328:
4326:
4323:
4321:
4317:Thromboxane A
4315:
4313:
4310:
4308:
4302:
4299:
4298:
4296:
4291:
4281:
4275:
4272:
4269:
4268:
4265:
4262:
4260:
4257:
4255:
4252:
4250:
4247:
4245:
4242:
4240:
4239:(alprostadil)
4233:
4231:
4224:
4222:
4219:
4217:
4214:
4212:
4209:
4207:
4204:
4202:
4199:
4197:
4194:
4192:
4189:
4187:
4184:
4182:
4179:
4177:
4174:
4171:
4170:
4168:
4163:
4153:
4147:
4144:
4142:
4139:
4137:
4134:
4132:
4129:
4127:
4120:
4118:
4112:
4110:
4107:
4105:
4102:
4100:
4097:
4095:
4092:
4090:
4087:
4085:
4082:
4080:
4077:
4074:
4073:
4071:
4066:
4056:
4046:
4043:
4041:
4038:
4036:
4029:
4027:
4024:
4022:
4019:
4017:
4014:
4012:
4009:
4007:
4004:
4002:
3999:
3997:
3991:
3988:
3987:
3985:
3981:
3975:
3972:
3970:
3967:
3965:
3962:
3960:
3957:
3954:
3953:
3950:
3947:
3945:
3938:
3936:
3935:(alprostadil)
3929:
3927:
3924:
3922:
3919:
3916:
3915:
3913:
3908:
3899:
3893:
3890:
3887:
3886:
3883:
3880:
3878:
3875:
3873:
3870:
3868:
3861:
3859:
3858:(alprostadil)
3852:
3850:
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3827:
3824:
3822:
3819:
3817:
3814:
3812:
3809:
3807:
3804:
3801:
3800:
3798:
3793:
3784:
3778:
3775:
3773:
3770:
3768:
3765:
3762:
3761:
3758:
3755:
3753:
3746:
3744:
3743:(alprostadil)
3737:
3735:
3732:
3730:
3727:
3724:
3723:
3721:
3716:
3707:
3701:
3698:
3696:
3693:
3691:
3688:
3686:
3683:
3681:
3678:
3675:
3674:
3671:
3668:
3666:
3659:
3657:
3656:(alprostadil)
3650:
3648:
3645:
3643:
3640:
3638:
3635:
3633:
3630:
3628:
3625:
3623:
3620:
3617:
3616:
3614:
3609:
3600:
3597:
3592:
3582:
3572:
3569:
3567:
3564:
3562:
3559:
3557:
3554:
3552:
3549:
3547:
3544:
3542:
3539:
3537:
3534:
3532:
3529:
3527:
3524:
3522:
3519:
3517:
3514:
3511:
3510:
3507:
3501:
3499:
3496:
3493:
3492:
3490:
3485:
3476:
3470:
3467:
3465:
3462:
3460:
3457:
3454:
3453:
3450:
3447:
3445:
3439:
3436:
3435:
3433:
3428:
3419:
3416:
3411:
3401:
3398:
3394:
3388:
3384:
3380:
3377:
3374:
3367:
3362:
3360:
3355:
3353:
3348:
3347:
3344:
3332:
3329:
3328:
3326:
3322:
3316:
3313:
3311:
3308:
3306:
3305:LTC4 synthase
3303:
3302:
3299:
3296:
3295:
3292:
3288:
3285:
3284:
3282:
3280:
3276:
3270:
3267:
3266:
3263:
3262:PGI2 synthase
3260:
3259:
3256:
3253:
3251:
3248:
3247:
3244:
3243:PGD2 synthase
3241:
3240:
3235:
3232:
3230:
3227:
3226:
3225:
3222:
3221:
3219:
3217:
3213:
3207:
3204:
3202:
3199:
3198:
3195:
3192:
3191:
3189:
3185:
3181:
3177:
3173:
3169:
3162:
3157:
3155:
3150:
3148:
3143:
3142:
3139:
3125:
3119:
3114:
3110:
3104:
3099:
3095:
3089:
3084:
3080:
3074:
3069:
3065:
3059:
3054:
3050:
3044:
3039:
3035:
3029:
3024:
3020:
3014:
3009:
3005:
2999:
2994:
2990:
2984:
2979:
2975:
2969:
2964:
2960:
2954:
2949:
2945:
2939:
2934:
2930:
2924:
2919:
2915:
2909:
2904:
2900:
2894:
2889:
2885:
2879:
2874:
2870:
2864:
2859:
2855:
2846:
2841:
2839:
2834:
2832:
2827:
2826:
2823:
2814:
2810:
2806:
2802:
2797:
2792:
2789:(5): 705–16.
2788:
2784:
2780:
2775:
2771:
2767:
2763:
2759:
2755:
2751:
2745:
2741:
2737:
2733:
2729:
2725:
2721:
2716:
2712:
2708:
2703:
2698:
2693:
2688:
2684:
2680:
2676:
2672:
2668:
2663:
2659:
2655:
2651:
2647:
2644:(3): 315–21.
2643:
2639:
2633:
2629:
2625:
2621:
2617:
2612:
2607:
2604:(2): 156–60.
2603:
2599:
2595:
2590:
2586:
2582:
2577:
2572:
2568:
2564:
2560:
2555:
2551:
2547:
2542:
2537:
2534:(3): 889–97.
2533:
2529:
2525:
2520:
2516:
2512:
2508:
2504:
2500:
2496:
2492:
2488:
2484:
2480:
2475:
2471:
2467:
2463:
2459:
2455:
2451:
2446:
2442:
2438:
2433:
2428:
2424:
2420:
2416:
2411:
2407:
2403:
2399:
2395:
2391:
2387:
2381:
2377:
2373:
2368:
2363:
2358:
2353:
2349:
2345:
2341:
2337:
2333:
2328:
2324:
2320:
2316:
2312:
2308:
2304:
2298:
2294:
2290:
2285:
2280:
2276:
2272:
2268:
2263:
2259:
2255:
2251:
2247:
2244:(5): 544–54.
2243:
2239:
2234:
2230:
2226:
2222:
2218:
2215:(5): 265–86.
2214:
2210:
2205:
2201:
2197:
2192:
2187:
2182:
2177:
2173:
2169:
2165:
2160:
2156:
2152:
2148:
2144:
2140:
2136:
2133:(2): 203–12.
2132:
2128:
2123:
2122:
2117:
2109:
2103:
2099:
2092:
2089:
2084:
2082:0-07-142280-3
2078:
2074:
2067:
2064:
2059:
2053:
2049:
2044:
2043:
2034:
2031:
2026:
2022:
2018:
2014:
2010:
2006:
1999:
1996:
1991:
1987:
1983:
1979:
1975:
1971:
1967:
1963:
1955:
1952:
1947:
1943:
1938:
1933:
1929:
1925:
1922:(2): 180–90.
1921:
1917:
1913:
1906:
1903:
1898:
1894:
1890:
1886:
1882:
1878:
1871:
1868:
1863:
1859:
1854:
1849:
1844:
1839:
1835:
1831:
1828:(9): 3400–4.
1827:
1823:
1819:
1812:
1809:
1804:
1800:
1795:
1790:
1786:
1782:
1778:
1771:
1768:
1763:
1759:
1755:
1751:
1747:
1743:
1736:
1733:
1728:
1724:
1719:
1714:
1709:
1704:
1701:(3): 575–85.
1700:
1696:
1692:
1685:
1682:
1677:
1673:
1668:
1663:
1658:
1653:
1649:
1645:
1641:
1634:
1631:
1626:
1620:
1617:
1612:
1608:
1604:
1600:
1596:
1592:
1589:(5): 618–24.
1588:
1584:
1577:
1574:
1569:
1565:
1561:
1557:
1553:
1549:
1542:
1539:
1534:
1530:
1526:
1522:
1517:
1512:
1508:
1504:
1503:FASEB Journal
1500:
1493:
1490:
1485:
1481:
1477:
1473:
1470:(2): 888–94.
1469:
1465:
1458:
1455:
1450:
1446:
1440:
1437:
1432:
1428:
1422:
1419:
1415:
1411:
1406:
1404:
1402:
1398:
1394:
1390:
1385:
1383:
1381:
1377:
1371:
1367:
1364:
1362:
1359:
1357:
1354:
1352:
1349:
1347:
1344:
1342:
1339:
1338:
1334:
1332:
1330:
1326:
1322:
1318:
1310:
1308:
1304:
1302:
1298:
1294:
1290:
1286:
1282:
1278:
1277:stereoisomers
1274:
1270:
1266:
1261:
1259:
1255:
1251:
1247:
1246:linoleic acid
1243:
1239:
1235:
1231:
1227:
1226:Prostaglandin
1220:
1218:
1215:
1211:
1207:
1203:
1199:
1195:
1191:
1187:
1183:
1175:
1173:
1171:
1167:
1159:
1157:
1155:
1151:
1148:
1144:
1140:
1137:
1133:
1129:
1125:
1113:
1108:
1104:
1100:
1097:
1093:
1086:
1084:
1081:
1077:
1073:
1069:
1066:
1062:
1058:
1051:
1049:
1043:
1039:
1036:
1030:
1028:
1024:
1018:
1014:
1010:
1006:
1002:
998:
994:
991:
987:
980:
978:
972:
968:
965:
959:
957:
953:
947:
943:
939:
935:
931:
927:
923:
920:
918:RefSeq (mRNA)
916:
909:
908:
903:
899:
896:
890:
889:
884:
880:
877:
875:
871:
864:
863:
858:
854:
851:
845:
844:
839:
835:
832:
830:
826:
819:
818:
813:
809:
806:
800:
799:
794:
790:
787:
785:
781:
778:
775:
773:
770:
766:
763:
759:
755:
748:
744:
739:
733:
730:
728:
725:
723:
720:
718:
715:
713:
710:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
674:
672:
669:
668:
662:
659:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
632:
629:
627:
624:
622:
619:
617:
614:
613:
611:
608:
607:
601:
598:
596:
593:
591:
588:
586:
583:
581:
578:
576:
573:
572:
570:
567:
566:
563:
562:Gene ontology
559:
555:
543:
538:
534:
527:
520:
515:
512:
510:
506:
498:
493:
482:
478:
474:
470:
466:
462:
458:
454:
450:
446:
445:
442:
438:
433:
430:
420:
416:
412:
408:
404:
401:skin of thigh
400:
396:
392:
388:
384:
383:
380:
376:
371:
368:
367:
364:
362:
358:
356:
355:
351:
350:
347:
345:
341:
337:
333:
329:
321:
316:
312:
308:
303:
293:
289:
282:
275:
269:
262:
254:
250:
246:
241:
237:
232:
228:
220:
215:
211:
207:
202:
192:
188:
181:
174:
168:
161:
157:
151:
147:
143:
138:
134:
129:
125:
121:
115:
111:
107:
103:
99:
95:
91:
87:
83:
79:
75:
71:
63:
58:
51:
46:
41:
37:
32:
27:
22:
5892:
5885:
5830:
5449:
5377:
5374:Propacetamol
5364:Parapropamol
5340:
5328:
5311:
5299:
5291:Floctafenine
5282:
5240:
5217:Azapropazone
5214:Pyrazolones:
5213:
5166:
5148:Tarenflurbil
5083:Flurbiprofen
5053:Dexibuprofen
5033:Benoxaprofen
5028:Alminoprofen
5024:
4951:Glucametacin
4862:
4839:Salicylamide
4829:Salacetamide
4770:
4719:Trimoprostil
4714:Tiprostanide
4699:Spiriprostil
4634:Naxaprostene
4584:Esuberaprost
4539:Cobiprostone
4337:Antagonists:
4336:
4300:
4271:Antagonists:
4270:
4264:Treprostinil
4172:
4104:Fluprostenol
4094:Cloprostenol
4075:
3989:
3956:Antagonists:
3955:
3921:Lubiprostone
3917:
3889:Antagonists:
3888:
3802:
3764:Antagonists:
3763:
3757:Treprostinil
3725:
3677:Antagonists:
3676:
3642:Lubiprostone
3618:
3513:Antagonists:
3512:
3494:
3456:Antagonists:
3455:
3449:Treprostinil
3437:
3279:Leukotrienes
3269:TXA synthase
3250:PGE synthase
3123:
3108:
3093:
3078:
3063:
3048:
3033:
3018:
3003:
2988:
2973:
2958:
2943:
2928:
2913:
2898:
2883:
2868:
2786:
2782:
2753:
2749:
2723:
2719:
2674:
2670:
2641:
2637:
2601:
2598:FEBS Letters
2597:
2566:
2562:
2531:
2527:
2482:
2478:
2456:(2): 751–7.
2453:
2449:
2422:
2418:
2392:(1): 87–92.
2389:
2385:
2339:
2335:
2309:(2): 433–8.
2306:
2302:
2274:
2270:
2241:
2237:
2212:
2208:
2171:
2167:
2130:
2126:
2097:
2091:
2072:
2066:
2041:
2033:
2011:(1): 41–60.
2008:
2004:
1998:
1965:
1961:
1954:
1919:
1915:
1905:
1880:
1876:
1870:
1825:
1821:
1811:
1784:
1780:
1770:
1745:
1741:
1735:
1698:
1694:
1684:
1647:
1643:
1633:
1619:
1586:
1582:
1576:
1551:
1547:
1541:
1506:
1502:
1492:
1467:
1463:
1457:
1448:
1439:
1430:
1421:
1314:
1305:
1280:
1272:
1268:
1262:
1224:
1198:angiogenesis
1179:
1163:
1146:
1138:
1131:
1127:
1123:
1122:
1045:
1023:NP_001258297
1020:
1013:NP_001258296
1009:NP_001258095
1005:NP_001258094
1001:NP_001258093
974:
952:NM_001271368
949:
942:NM_001271367
938:NM_001271166
934:NM_001271165
930:NM_001271164
905:
886:
860:
841:
815:
796:
776:
771:
590:heme binding
359:
352:
217:122,395,703
204:122,370,530
65:External IDs
5831:Precursors:
5771:Nicogrelate
5751:Furegrelate
5692:Bimatoprost
5602:Trifenagrel
5592:Tiflamizole
5562:Rutecarpine
5547:Resveratrol
5488:Glimepiride
5453:Anitrazafen
5431:Robenacoxib
5411:Lumiracoxib
5344:Acetanilide
5286:Antrafenine
5244:Ampiroxicam
5138:Pranoprofen
5123:Naproxcinod
5016:Zidometacin
4941:Fenclofenac
4866:Aceclofenac
4804:Ethenzamide
4799:Dipyrocetyl
4694:Rosaprostol
4674:Posaraprost
4659:Penprostene
4649:Ornoprostil
4629:Mexiprostil
4624:Meteneprost
4579:Eptaloprost
4554:Dimoxaprost
4519:Arbaprostil
4473:Seratrodast
4365:BMS-180,291
4196:Carbacyclin
4146:Unoprostone
4126:(dinoprost)
4109:Latanoprost
4084:Bimatoprost
4079:Alfaprostol
4035:(dinoprost)
3974:ONO-AE3-208
3926:Misoprostol
3882:Sulprostone
3872:Remiprostol
3841:Misoprostol
3836:Latanoprost
3811:Carbacyclin
3772:PF-04418948
3734:Misoprostol
3670:Sulprostone
3647:Misoprostol
3637:Latanoprost
3571:Vidupiprant
3561:Timapiprant
3556:Setipiprant
3531:Fevipiprant
3498:Indometacin
3469:Vidupiprant
3464:Laropiprant
3216:Prostanoids
3178:metabolism
2851:PDB gallery
2726:(1): 81–5.
1238:dioxygenase
1210:homeostasis
1202:endothelial
455:granulocyte
397:skin of arm
318:36,142,284
305:36,120,438
43:Identifiers
5910:Categories
5801:Samixogrel
5796:Rolafagrel
5781:Picotamide
5761:Midazogrel
5736:Camonagrel
5597:Timegadine
5542:Pamicogrel
5513:Licofelone
5493:Hyperforin
5458:Clobuzarit
5446:Valdecoxib
5441:Tilmacoxib
5426:Polmacoxib
5401:Etoricoxib
5369:Phenacetin
5337:Nimesulide
5315:Clonixeril
5308:Proquazone
5264:Lornoxicam
5163:Vedaprofen
5113:Miroprofen
5108:Loxoprofen
5103:Ketoprofen
5098:Indoprofen
5073:Fenoprofen
4986:Oxametacin
4981:Nabumetone
4921:Diclofenac
4916:Clometacin
4911:Cinmetacin
4906:Bumadizone
4886:Alclofenac
4871:Acemetacin
4809:Guacetisal
4794:Diflunisal
4744:inhibitors
4709:Tilsuprost
4689:Rivenprost
4684:Rioprostil
4679:Prostalene
4664:Pimilprost
4654:Oxoprostol
4644:Nocloprost
4619:Luprostiol
4609:Lanproston
4604:Froxiprost
4599:Flunoprost
4589:Etiproston
4574:Enisoprost
4569:Eganoprost
4529:Ciprostene
4498:Terutroban
4488:Sulotroban
4468:Samixogrel
4453:Ramatroban
4440:Picotamide
4425:Mipitroban
4420:Linotroban
4405:Imitrodast
4395:ICI-192605
4390:ICI-185282
4375:Domitroban
4355:Argatroban
4254:Taprostene
4176:ACT-333679
4141:Travoprost
4136:Tafluprost
4131:Sulotroban
4089:Carboprost
4045:Taprenepag
4026:Omidenepag
4021:Nocloprost
4011:Evatanepag
4006:Carboprost
3959:Grapiprant
3551:Ramatroban
3459:Asapiprant
3379:modulators
3373:Prostanoid
3176:eicosanoid
3168:Metabolism
1968:(1): 319.
1416:, May 2017
1395:, May 2017
1372:References
1242:peroxidase
363:(ortholog)
86:HomoloGene
5806:Terbogrel
5786:Pirmagrel
5746:Dazoxiben
5741:Dazmegrel
5634:Retinoids
5552:Romazarit
5498:Itazigrel
5483:FR-122047
5478:Flumizole
5436:Rofecoxib
5421:Parecoxib
5416:Mavacoxib
5406:Firocoxib
5396:Deracoxib
5391:Cimicoxib
5386:Celecoxib
5381:Apricoxib
5332:Flosulide
5296:Glafenine
5279:Tenoxicam
5274:Piroxicam
5269:Meloxicam
5153:Tepoxalin
5133:Pirprofen
5128:Oxaprozin
5093:Ibuproxam
5088:Ibuprofen
5048:Carprofen
5043:Butibufen
5021:Zomepirac
4991:Oxindanac
4976:Mofezolac
4971:Lonazolac
4966:Ketorolac
4946:Fentiazac
4901:Bufexamac
4896:Bromfenac
4876:Aclofenac
4859:Triflusal
4849:Salsalate
4774:Aloxiprin
4724:Viprostol
4669:Piriprost
4639:Nileprost
4614:Limaprost
4564:Ecraprost
4559:Doxaprost
4549:Deprostil
4534:Clinprost
4493:Terbogrel
4483:SQ-29,548
4478:SQ-28,668
4435:ONO-11120
4400:Ifetroban
4370:Daltroban
4360:Bay U3405
4330:Vapiprost
4301:Agonists:
4274:RO1138452
4249:Selexipag
4244:Ralinepag
4201:Cicaprost
4191:BMY-45778
4186:Beraprost
4173:Agonists:
4099:Enprostil
4076:Agonists:
4040:Simenepag
4016:Gemeprost
3990:Agonists:
3964:GW-627368
3918:Agonists:
3821:Enprostil
3816:Cicaprost
3806:Beraprost
3803:Agonists:
3729:Butaprost
3726:Agonists:
3627:Enprostil
3622:Beraprost
3619:Agonists:
3526:Bay U3405
3495:Agonists:
3438:Agonists:
3376:signaling
3324:Ungrouped
3187:Precursor
1190:cytokines
1172:in 1988.
1141:), is an
1048:NP_032995
1027:NP_542158
997:NP_000953
977:NM_008969
956:NM_080591
926:NM_000962
762:Orthologs
651:cytoplasm
120:1.14.99.1
114:EC number
94:GeneCards
5882:See also
5791:Ridogrel
5766:Nafagrel
5756:Isbogrel
5639:Selenium
5607:Tropesin
5582:SC-58125
5567:Satigrel
5532:NCX-4040
5508:L-670596
5503:L-655240
5463:Curcumin
5325:Flunixin
5320:Clonixin
5259:Isoxicam
5254:Enolicam
5249:Droxicam
5227:Isopyrin
5222:Dipyrone
5143:Suprofen
5118:Naproxen
5068:Fenbufen
5011:Tolmetin
5001:Sulindac
4936:Felbinac
4931:Etodolac
4891:Bendazac
4704:Tiaprost
4524:Ataprost
4512:Unsorted
4458:Ridogrel
4430:ONO-3708
4415:L-670596
4410:L-655240
4385:GR-32191
4001:Aganepag
3983:Unsorted
3969:L-161982
3949:TCS-2510
3892:L-798106
3777:TG 4-155
3700:SC-51322
3695:SC-51089
3690:SC-19220
3685:ONO-8130
3521:AZD-1981
3516:ADC-3680
3387:Receptor
2813:12704830
2628:26397839
2258:17071117
2229:15375804
2200:21385433
2155:12728545
2147:11897504
2025:18549814
1982:23224081
1946:21068195
1762:16005201
1727:19752399
1676:12242329
1568:12973429
1533:46147389
1412:–
1391:–
1335:See also
1285:lipoxins
1230:synthase
1221:Function
1182:isozymes
1096:Wikidata
741:Sources:
641:membrane
393:monocyte
5811:U63557A
5776:Ozagrel
5587:Tenidap
5527:NCX-466
5473:FK-3311
5468:DuP-697
5354:Bucetin
4881:Amfenac
4834:Salicin
4503:TRA-418
4350:AA-2414
4340:12-HETE
4325:U-46619
4259:TRA-418
4216:MRE-269
3767:AH-6809
3680:AH-6809
3566:TM30089
3546:QAV-680
3541:MK-7246
3536:MK-1029
3393:ligands
3180:enzymes
2805:9630216
2770:9435560
2740:8900446
2711:8643612
2679:Bibcode
2658:8581564
2620:8365485
2585:8349699
2550:8181472
2515:4340064
2507:8121489
2487:Bibcode
2470:7864630
2441:7559624
2406:7521167
2376:7510883
2344:Bibcode
2323:1734857
2293:1587858
2191:3062590
1990:9158244
1937:3033693
1897:9785378
1862:4215079
1830:Bibcode
1803:4723909
1718:2817587
1611:9407329
1603:9773924
1525:1907252
1484:2512924
1414:Ensembl
1393:Ensembl
1329:aspirin
1321:aspirin
1275:)-HETE
1160:History
874:UniProt
829:Ensembl
768:Species
747:QuickGO
616:nucleus
338:pattern
50:Aliases
5824:Others
5673:HQL-79
5577:SC-560
5572:SC-236
5537:NS-398
4738:Enzyme
4380:EP-045
4345:13-APA
4285:TP (TX
4221:NS-304
4181:AFP-07
2811:
2803:
2768:
2738:
2709:
2699:
2656:
2626:
2618:
2583:
2548:
2513:
2505:
2479:Nature
2468:
2439:
2404:
2374:
2364:
2321:
2291:
2256:
2227:
2198:
2188:
2174:: 22.
2153:
2145:
2104:
2079:
2054:
2023:
1988:
1980:
1944:
1934:
1895:
1860:
1853:433780
1850:
1801:
1760:
1725:
1715:
1674:
1667:129799
1664:
1609:
1601:
1566:
1531:
1523:
1482:
1297:CYP2S1
1170:cloned
1143:enzyme
1082:search
1080:PubMed
907:P22437
888:P23219
784:Entrez
509:BioGPS
196:9q33.2
74:176805
21:MT-CO1
16:Enzyme
4463:S-145
4312:I-BOP
4157:IP (I
4060:FP (F
3586:EP (E
3405:DP (D
3234:PTGS2
3229:PTGS1
2809:S2CID
2702:39283
2624:S2CID
2511:S2CID
2367:43306
2151:S2CID
1986:S2CID
1607:S2CID
1529:S2CID
1356:NSAID
1214:COX-3
1186:COX-2
1147:PTGS1
1139:PTGS1
1128:COX-1
817:19224
777:Mouse
772:Human
743:Amigo
361:Mouse
354:Human
301:Start
236:Mouse
200:Start
133:Human
98:PTGS1
82:97797
57:PTGS1
29:PTGS1
5724:TXAS
5682:PGFS
5663:PGES
4761:PTGS
3331:HPGD
3124:2ayl
3109:1u67
3094:1q4g
3079:1pth
3064:1prh
3049:1pgg
3034:1pgf
3019:1pge
3004:1igz
2989:1igx
2974:1ht8
2959:1ht5
2944:1fe2
2929:1eqh
2914:1eqg
2899:1ebv
2884:1diy
2869:1cqe
2801:PMID
2783:Cell
2766:PMID
2736:PMID
2707:PMID
2654:PMID
2616:PMID
2581:PMID
2546:PMID
2503:PMID
2466:PMID
2437:PMID
2402:PMID
2372:PMID
2319:PMID
2289:PMID
2254:PMID
2225:PMID
2196:PMID
2143:PMID
2102:ISBN
2077:ISBN
2052:ISBN
2021:PMID
1978:PMID
1942:PMID
1893:PMID
1858:PMID
1799:PMID
1758:PMID
1723:PMID
1672:PMID
1599:PMID
1564:PMID
1521:PMID
1480:PMID
1258:PGG2
1248:and
1192:and
1150:gene
1136:HUGO
798:5742
344:Bgee
292:Band
253:Chr.
191:Band
150:Chr.
70:OMIM
5701:PGI
5618:PGD
4756:COX
2791:doi
2758:doi
2754:273
2728:doi
2697:PMC
2687:doi
2646:doi
2606:doi
2602:330
2571:doi
2567:268
2536:doi
2532:221
2495:doi
2483:367
2458:doi
2454:316
2427:doi
2423:270
2394:doi
2390:203
2362:PMC
2352:doi
2311:doi
2307:182
2279:doi
2275:267
2246:doi
2217:doi
2186:PMC
2176:doi
2135:doi
2048:661
2013:doi
2009:135
1970:doi
1966:108
1932:PMC
1924:doi
1885:doi
1848:PMC
1838:doi
1789:doi
1785:248
1750:doi
1713:PMC
1703:doi
1662:PMC
1652:doi
1591:doi
1556:doi
1511:doi
1472:doi
1468:165
1200:in
483:lip
314:End
213:End
102:OMA
90:743
78:MGI
5912::
5649:,
5645:,
5448:;
5376:;
5339:;
5327:;
5310:;
5298:;
5281:;
5239:;
5212:;
5165:;
5023:;
4861:;
4287:A2
4124:2α
4062:2α
4033:2α
3903:EP
3788:EP
3711:EP
3604:EP
3480:DP
3423:DP
3174:–
3170::
2807:.
2799:.
2787:93
2785:.
2781:.
2764:.
2752:.
2734:.
2724:51
2722:.
2705:.
2695:.
2685:.
2675:93
2673:.
2669:.
2652:.
2640:.
2622:.
2614:.
2600:.
2596:.
2579:.
2565:.
2561:.
2544:.
2530:.
2526:.
2509:.
2501:.
2493:.
2481:.
2464:.
2452:.
2435:.
2421:.
2417:.
2400:.
2388:.
2370:.
2360:.
2350:.
2340:91
2338:.
2334:.
2317:.
2305:.
2287:.
2273:.
2269:.
2252:.
2242:17
2240:.
2223:.
2213:28
2211:.
2194:.
2184:.
2170:.
2166:.
2149:.
2141:.
2131:80
2129:.
2050:.
2019:.
2007:.
1984:.
1976:.
1964:.
1940:.
1930:.
1920:39
1918:.
1914:.
1891:.
1881:56
1879:.
1856:.
1846:.
1836:.
1826:71
1824:.
1820:.
1797:.
1783:.
1779:.
1756:.
1746:73
1744:.
1721:.
1711:.
1699:51
1697:.
1693:.
1670:.
1660:.
1648:99
1646:.
1642:.
1605:.
1597:.
1587:33
1585:.
1562:.
1552:35
1550:.
1527:.
1519:.
1505:.
1501:.
1478:.
1466:.
1447:.
1429:.
1400:^
1379:^
1323:.
1156:.
745:/
320:bp
307:bp
219:bp
206:bp
100:;
96::
92:;
88::
84:;
80::
76:;
72::
5869:2
5861:2
5705:S
5703:2
5653:)
5641:(
5622:S
5620:2
5522:)
5520:2
4763:)
4759:(
4746:)
4742:(
4447:2
4319:2
4306:2
4289:)
4237:1
4228:2
4161:)
4159:2
4116:2
4064:)
3995:2
3942:2
3933:1
3905:4
3865:2
3856:1
3848:2
3790:3
3750:2
3741:1
3713:2
3663:2
3654:1
3606:1
3590:)
3588:2
3505:2
3482:2
3443:2
3425:1
3409:)
3407:2
3395:)
3391:(
3365:e
3358:t
3351:v
3289:/
3160:e
3153:t
3146:v
2844:e
2837:t
2830:v
2815:.
2793::
2772:.
2760::
2742:.
2730::
2713:.
2689::
2681::
2660:.
2648::
2642:4
2630:.
2608::
2587:.
2573::
2552:.
2538::
2517:.
2497::
2489::
2472:.
2460::
2443:.
2429::
2408:.
2396::
2378:.
2354::
2346::
2325:.
2313::
2295:.
2281::
2260:.
2248::
2231:.
2219::
2202:.
2178::
2172:8
2157:.
2137::
2110:.
2085:.
2060:.
2027:.
2015::
1992:.
1972::
1948:.
1926::
1899:.
1887::
1864:.
1840::
1832::
1805:.
1791::
1764:.
1752::
1729:.
1705::
1678:.
1654::
1627:.
1613:.
1593::
1570:.
1558::
1535:.
1513::
1507:5
1486:.
1474::
1451:.
1433:.
1281:R
1273:S
1269:R
1134:(
1126:(
238:)
135:)
104::
23:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
