26:
508:
2127:
363:
919:"A distinct sequence in the adenine nucleotide translocase from Artemia franciscana embryos is associated with insensitivity to bongkrekate and atypical effects of adenine nucleotides on Ca2+ uptake and sequestration"
1094:
873:
Menze MA, Hutchinson K, Laborde SM, Hand SC (July 2005). "Mitochondrial permeability transition in the crustacean
Artemia franciscana: absence of a calcium-regulated pore in the face of profound calcium storage".
1087:
1080:
167:
1707:
1475:
1006:
441:
1528:
1616:
824:"Complex contribution of cyclophilin D to Ca2+-induced permeability transition in brain mitochondria, with relation to the bioenergetic state"
115:
432:
Cyclophilin D (PPIF, note that literature is confusing, the mitochondrial cyclophilin is encoded by the PPIF gene), which is located in the
464:. Cyclophilin D is thought to regulate the opening of the pore because cyclosporin A, which binds to CyP-D, inhibits the pore opening.
1700:
467:
However, mitochondria obtained from the cysts of
Artemia franciscana, do not exhibit the mitochondrial permeability transition pore
1846:
1220:
677:
Hacker J, Fischer G (November 1993). "Immunophilins: structure-function relationship and possible role in microbial pathogenicity".
589:"Structural and evolutionary relationships among the immunophilins: two ubiquitous families of peptidyl-prolyl cis-trans isomerases"
552:
Stamnes MA, Rutherford SL, Zuker CS (September 1992). "Cyclophilins: a new family of proteins involved in intracellular folding".
1365:
2002:
720:
Thali M, Bukovsky A, Kondo E, et al. (24 November 1994). "Functional association of cyclophilin A with HIV-1 virions".
187:
1693:
2117:
445:
1072:
1517:
1107:
370:
305:
1987:
2103:
2090:
2077:
2064:
2051:
2038:
2025:
1733:
497:
1997:
389:. Other cyclophilins have similar structures to cyclophilin A. The cyclosporin-cyclophilin A complex inhibits a
1951:
1894:
1724:
1066:
1720:
480:
Overexpression of
Cyclophilin A has been linked to poor response to inflammatory diseases, the progression or
175:
1899:
25:
1920:
1839:
1281:
1103:
274:
1992:
171:
1181:
729:
453:
433:
215:
128:
1007:
J&J targets degenerative diseases in cyclophilin inhibitor partnership. Dan
Stanton. 08-Dec-2015
424:
virus infection, and its incorporation into new virus particles is essential for HIV-1 infectivity.
2152:
1956:
266:
1889:
899:
753:
702:
618:
1480:
456:, increases the matrix volume, and disrupts the mitochondrial outer membrane. As a result, the
2147:
1561:
1556:
1507:
1488:
1041:
989:
940:
891:
855:
804:
745:
694:
659:
610:
569:
211:
162:
39:
1606:
1586:
1576:
1571:
1541:
1935:
1930:
1904:
1832:
1813:
1649:
1460:
1031:
979:
971:
930:
883:
845:
835:
794:
784:
737:
686:
649:
600:
561:
342:
223:
219:
351:
346:
154:
1982:
1966:
1879:
1402:
1393:
1256:
1110:
406:
251:
1062:
773:"Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D"
733:
2131:
2020:
1961:
1166:
984:
959:
850:
823:
690:
654:
637:
460:
fall into a functional disorder, so the opening of the pore plays an important role in
30:
507:
2141:
1925:
1884:
1147:
935:
918:
565:
414:
235:
231:
120:
706:
622:
71:
1874:
1375:
903:
757:
457:
437:
150:
1204:
84:
1685:
96:
2098:
2033:
1869:
1422:
1370:
1266:
1191:
1158:
1129:
1120:
605:
588:
493:
402:
398:
382:
378:
317:
309:
207:
34:
2126:
1036:
1019:
887:
481:
461:
394:
386:
373:(CYPA) also known as peptidylprolyl isomerase A (PPIA), which is found in the
2072:
2046:
1716:
1434:
840:
771:
Basso E, Fante L, Fowlkes J, Petronilli V, Forte MA, Bernardi P (May 2005).
440:, is only a modulatory, but may or may not be a structural component of the
410:
258:
227:
1045:
993:
975:
944:
895:
859:
808:
789:
772:
573:
749:
698:
663:
614:
420:
Cyclophilin A is also known to be recruited by the Gag polyprotein during
124:
1808:
1484:
1438:
1137:
799:
289:
Human genes encoding proteins containing the cyclophilin domain include:
278:
270:
262:
91:
1601:
1596:
1591:
1581:
1566:
1551:
1546:
1536:
449:
390:
374:
247:
203:
108:
103:
222:. They are found in all domains of life. These proteins have peptidyl
43:
2085:
1855:
1790:
1750:
1745:
1674:
1669:
1664:
1659:
1654:
1644:
1639:
1634:
1629:
1624:
1357:
1348:
1241:
741:
182:
500:. Cyclophilin inhibition may also be a therapy for liver diseases.
2059:
1795:
1785:
1780:
1775:
1770:
1765:
1760:
1755:
1329:
1325:
421:
361:
338:
334:
330:
326:
1741:
1470:
1465:
1412:
1407:
1397:
1333:
1305:
1289:
1285:
1199:
1176:
1171:
1143:
1020:"Cyclophilin inhibition as potential therapy for liver diseases"
321:
313:
301:
297:
293:
261:
and highly abundant protein. The protein belongs to a family of
144:
78:
66:
1828:
1689:
1076:
362:
1444:
1430:
502:
409:
by halting the production of the pro-inflammatory molecules
1824:
273:
have been found within single cells, including inside the
822:
Doczi J, Turiák L, Vajda S, et al. (February 2011).
917:
Konràd C, Kiss G, Töröcsik B, et al. (March 2011).
19:
Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
519:
2115:
638:"Peptidylproline cis-trans-isomerases: immunophilins"
2011:
1975:
1944:
1913:
1862:
1732:
1615:
1527:
1506:
1453:
1421:
1386:
1356:
1347:
1318:
1298:
1274:
1265:
1249:
1240:
1233:
1213:
1190:
1157:
1128:
1117:
181:
161:
143:
138:
114:
102:
90:
77:
65:
57:
52:
18:
444:. The pore opening raises the permeability of the
405:, the inhibition of which is thought to suppress
960:"Cyclophilin A: a key player for human disease"
958:Nigro, P; Pompilio, G; Capogrossi, M C (2013).
587:Trandinh CC, Pao GM, Saier MH (December 1992).
1840:
1701:
1088:
8:
876:Am. J. Physiol. Regul. Integr. Comp. Physiol
1847:
1833:
1825:
1708:
1694:
1686:
1353:
1271:
1246:
1237:
1125:
1095:
1081:
1073:
442:mitochondrial permeability transition pore
366:Cyclophilin A + HIV peptid (green), Human.
135:
24:
1065:at the U.S. National Library of Medicine
1035:
983:
934:
849:
839:
798:
788:
653:
604:
2122:
544:
265:, including cyclophilins B and C, and
15:
1018:Naoumov, Nikolai V. (November 2014).
206:named after their ability to bind to
7:
269:cyclophilin-related protein. Major
691:10.1111/j.1365-2958.1993.tb00917.x
655:10.1111/j.1432-1033.1993.tb18189.x
214:which is usually used to suppress
14:
1221:Polymeric immunoglobulin receptor
33:of cyclophilin A in complex with
2125:
936:10.1111/j.1742-4658.2010.08001.x
506:
492:Cyclophilin inhibitors, such as
496:, are being developed to treat
1433:(with two glycoprotein chains
1:
1529:Killer-cell IG-like receptors
139:Available protein structures:
566:10.1016/0962-8924(92)90200-7
488:Cyclophilins as drug targets
446:mitochondrial inner membrane
1617:Leukocyte IG-like receptors
606:10.1096/fasebj.6.15.1464374
2169:
1108:immunoglobulin superfamily
1037:10.1016/j.jhep.2014.07.008
888:10.1152/ajpregu.00844.2004
636:Galat A (September 1993).
498:neurodegenerative diseases
2003:Michaelis–Menten kinetics
250:residues and facilitates
134:
23:
1895:Diffusion-limited enzyme
1067:Medical Subject Headings
1104:Transmembrane receptors
841:10.1074/jbc.M110.196600
202:(CYPs) are a family of
976:10.1038/cddis.2013.410
964:Cell Death and Disease
790:10.1074/jbc.C500089200
484:of cancer, and aging.
367:
285:Mammalian cyclophilins
1988:Eadie–Hofstee diagram
1921:Allosteric regulation
1024:Journal of Hepatology
471:Clinical significance
365:
275:Endoplasmic reticulum
1998:Lineweaver–Burk plot
454:mitochondrial matrix
277:, and some are even
210:(cyclosporin A), an
1454:Accessory molecules
1319:Accessory molecules
734:1994Natur.372..363T
452:molecules into the
448:, allows influx of
381:structure with two
267:natural killer cell
257:Cyclophilin A is a
1957:Enzyme superfamily
1890:Enzyme promiscuity
1518:cytokine receptors
1118:Antibody receptor:
518:. You can help by
368:
2113:
2112:
1822:
1821:
1683:
1682:
1508:Cytokine receptor
1502:
1501:
1498:
1497:
1343:
1342:
1314:
1313:
1229:
1228:
728:(6504): 363–365.
536:
535:
220:organ transplants
212:immunosuppressant
197:
196:
193:
192:
188:structure summary
2160:
2130:
2129:
2121:
1993:Hanes–Woolf plot
1936:Enzyme activator
1931:Enzyme inhibitor
1905:Enzyme catalysis
1849:
1842:
1835:
1826:
1814:Prolyl isomerase
1710:
1703:
1696:
1687:
1387:Antigen receptor
1354:
1272:
1250:Antigen receptor
1247:
1238:
1234:Antigen receptor
1192:Alpha (α)/mu (μ)
1126:
1111:immune receptors
1097:
1090:
1083:
1074:
1050:
1049:
1039:
1030:(5): 1166–1174.
1015:
1009:
1004:
998:
997:
987:
955:
949:
948:
938:
914:
908:
907:
870:
864:
863:
853:
843:
819:
813:
812:
802:
792:
783:(19): 18558–61.
768:
762:
761:
742:10.1038/372363a0
717:
711:
710:
674:
668:
667:
657:
633:
627:
626:
608:
584:
578:
577:
554:Trends Cell Biol
549:
531:
528:
510:
503:
226:activity, which
224:prolyl isomerase
136:
46:
28:
16:
2168:
2167:
2163:
2162:
2161:
2159:
2158:
2157:
2138:
2137:
2136:
2124:
2116:
2114:
2109:
2021:Oxidoreductases
2007:
1983:Enzyme kinetics
1971:
1967:List of enzymes
1940:
1909:
1880:Catalytic triad
1858:
1853:
1823:
1818:
1728:
1714:
1684:
1679:
1611:
1523:
1494:
1449:
1417:
1382:
1339:
1310:
1294:
1261:
1225:
1209:
1186:
1153:
1119:
1113:
1101:
1059:
1054:
1053:
1017:
1016:
1012:
1005:
1001:
957:
956:
952:
916:
915:
911:
872:
871:
867:
821:
820:
816:
770:
769:
765:
719:
718:
714:
676:
675:
671:
642:Eur. J. Biochem
635:
634:
630:
599:(15): 3410–20.
586:
585:
581:
551:
550:
546:
541:
532:
526:
523:
516:needs expansion
490:
478:
473:
430:
407:organ rejection
360:
287:
252:protein folding
218:after internal
48:
38:
37:(yellow). From
12:
11:
5:
2166:
2164:
2156:
2155:
2150:
2140:
2139:
2135:
2134:
2111:
2110:
2108:
2107:
2094:
2081:
2068:
2055:
2042:
2029:
2015:
2013:
2009:
2008:
2006:
2005:
2000:
1995:
1990:
1985:
1979:
1977:
1973:
1972:
1970:
1969:
1964:
1959:
1954:
1948:
1946:
1945:Classification
1942:
1941:
1939:
1938:
1933:
1928:
1923:
1917:
1915:
1911:
1910:
1908:
1907:
1902:
1897:
1892:
1887:
1882:
1877:
1872:
1866:
1864:
1860:
1859:
1854:
1852:
1851:
1844:
1837:
1829:
1820:
1819:
1817:
1816:
1811:
1806:
1799:
1798:
1793:
1788:
1783:
1778:
1773:
1768:
1763:
1758:
1753:
1748:
1738:
1736:
1730:
1729:
1715:
1713:
1712:
1705:
1698:
1690:
1681:
1680:
1678:
1677:
1672:
1667:
1662:
1657:
1652:
1647:
1642:
1637:
1632:
1627:
1621:
1619:
1613:
1612:
1610:
1609:
1604:
1599:
1594:
1589:
1584:
1579:
1574:
1569:
1564:
1559:
1554:
1549:
1544:
1539:
1533:
1531:
1525:
1524:
1522:
1521:
1512:
1510:
1504:
1503:
1500:
1499:
1496:
1495:
1493:
1492:
1478:
1473:
1468:
1463:
1457:
1455:
1451:
1450:
1448:
1447:
1442:
1427:
1425:
1419:
1418:
1416:
1415:
1410:
1405:
1400:
1390:
1388:
1384:
1383:
1381:
1380:
1379:
1378:
1373:
1362:
1360:
1351:
1345:
1344:
1341:
1340:
1338:
1337:
1322:
1320:
1316:
1315:
1312:
1311:
1309:
1308:
1302:
1300:
1296:
1295:
1293:
1292:
1278:
1276:
1269:
1263:
1262:
1260:
1259:
1253:
1251:
1244:
1235:
1231:
1230:
1227:
1226:
1224:
1223:
1217:
1215:
1211:
1210:
1208:
1207:
1202:
1196:
1194:
1188:
1187:
1185:
1184:
1179:
1174:
1169:
1163:
1161:
1155:
1154:
1152:
1151:
1140:
1134:
1132:
1123:
1115:
1114:
1102:
1100:
1099:
1092:
1085:
1077:
1071:
1070:
1058:
1057:External links
1055:
1052:
1051:
1010:
999:
950:
909:
865:
834:(8): 6345–53.
814:
763:
712:
679:Mol. Microbiol
669:
648:(3): 689–707.
628:
579:
543:
542:
540:
537:
534:
533:
513:
511:
489:
486:
477:
474:
472:
469:
429:
426:
359:
356:
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354:
349:
324:
286:
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195:
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165:
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118:
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99:
94:
88:
87:
82:
75:
74:
69:
63:
62:
59:
55:
54:
50:
49:
31:Ribbon diagram
29:
21:
20:
13:
10:
9:
6:
4:
3:
2:
2165:
2154:
2151:
2149:
2146:
2145:
2143:
2133:
2128:
2123:
2119:
2105:
2101:
2100:
2095:
2092:
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2079:
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2048:
2043:
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2036:
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2027:
2023:
2022:
2017:
2016:
2014:
2010:
2004:
2001:
1999:
1996:
1994:
1991:
1989:
1986:
1984:
1981:
1980:
1978:
1974:
1968:
1965:
1963:
1962:Enzyme family
1960:
1958:
1955:
1953:
1950:
1949:
1947:
1943:
1937:
1934:
1932:
1929:
1927:
1926:Cooperativity
1924:
1922:
1919:
1918:
1916:
1912:
1906:
1903:
1901:
1898:
1896:
1893:
1891:
1888:
1886:
1885:Oxyanion hole
1883:
1881:
1878:
1876:
1873:
1871:
1868:
1867:
1865:
1861:
1857:
1850:
1845:
1843:
1838:
1836:
1831:
1830:
1827:
1815:
1812:
1810:
1807:
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1797:
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1740:
1739:
1737:
1735:
1731:
1726:
1722:
1718:
1711:
1706:
1704:
1699:
1697:
1692:
1691:
1688:
1676:
1673:
1671:
1668:
1666:
1663:
1661:
1658:
1656:
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1651:
1648:
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1638:
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1628:
1626:
1623:
1622:
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1618:
1614:
1608:
1605:
1603:
1600:
1598:
1595:
1593:
1590:
1588:
1585:
1583:
1580:
1578:
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1573:
1570:
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1565:
1563:
1560:
1558:
1555:
1553:
1550:
1548:
1545:
1543:
1540:
1538:
1535:
1534:
1532:
1530:
1526:
1520:
1519:
1514:
1513:
1511:
1509:
1505:
1490:
1486:
1483:(also called
1482:
1479:
1477:
1474:
1472:
1469:
1467:
1464:
1462:
1459:
1458:
1456:
1452:
1446:
1443:
1440:
1436:
1432:
1429:
1428:
1426:
1424:
1420:
1414:
1411:
1409:
1406:
1404:
1401:
1399:
1395:
1392:
1391:
1389:
1385:
1377:
1374:
1372:
1369:
1368:
1367:
1364:
1363:
1361:
1359:
1355:
1352:
1350:
1346:
1335:
1331:
1327:
1324:
1323:
1321:
1317:
1307:
1304:
1303:
1301:
1297:
1291:
1287:
1283:
1280:
1279:
1277:
1273:
1270:
1268:
1264:
1258:
1255:
1254:
1252:
1248:
1245:
1243:
1239:
1236:
1232:
1222:
1219:
1218:
1216:
1212:
1206:
1203:
1201:
1198:
1197:
1195:
1193:
1189:
1183:
1180:
1178:
1175:
1173:
1170:
1168:
1165:
1164:
1162:
1160:
1156:
1149:
1148:C-type lectin
1145:
1141:
1139:
1136:
1135:
1133:
1131:
1127:
1124:
1122:
1116:
1112:
1109:
1105:
1098:
1093:
1091:
1086:
1084:
1079:
1078:
1075:
1068:
1064:
1061:
1060:
1056:
1047:
1043:
1038:
1033:
1029:
1025:
1021:
1014:
1011:
1008:
1003:
1000:
995:
991:
986:
981:
977:
973:
969:
965:
961:
954:
951:
946:
942:
937:
932:
929:(5): 822–36.
928:
924:
920:
913:
910:
905:
901:
897:
893:
889:
885:
882:(1): R68–76.
881:
877:
869:
866:
861:
857:
852:
847:
842:
837:
833:
829:
828:J. Biol. Chem
825:
818:
815:
810:
806:
801:
800:11577/1474540
796:
791:
786:
782:
778:
777:J. Biol. Chem
774:
767:
764:
759:
755:
751:
747:
743:
739:
735:
731:
727:
723:
716:
713:
708:
704:
700:
696:
692:
688:
685:(3): 445–56.
684:
680:
673:
670:
665:
661:
656:
651:
647:
643:
639:
632:
629:
624:
620:
616:
612:
607:
602:
598:
594:
590:
583:
580:
575:
571:
567:
563:
559:
555:
548:
545:
538:
530:
527:December 2015
521:
517:
514:This section
512:
509:
505:
504:
501:
499:
495:
487:
485:
483:
475:
470:
468:
465:
463:
459:
455:
451:
447:
443:
439:
435:
428:Cyclophilin D
427:
425:
423:
418:
416:
415:interleukin 2
412:
408:
404:
400:
396:
392:
388:
384:
383:alpha helices
380:
376:
372:
371:Cyclophilin A
364:
358:Cyclophilin A
357:
353:
350:
348:
344:
340:
336:
332:
328:
325:
323:
319:
315:
311:
307:
303:
299:
295:
292:
291:
290:
284:
282:
280:
276:
272:
268:
264:
260:
255:
253:
249:
245:
241:
237:
236:peptide bonds
233:
232:isomerization
229:
225:
221:
217:
213:
209:
205:
201:
189:
186:
184:
180:
177:
173:
169:
166:
164:
160:
156:
152:
149:
146:
142:
137:
133:
130:
126:
122:
119:
117:
113:
110:
107:
105:
101:
98:
95:
93:
89:
86:
83:
80:
76:
73:
70:
68:
64:
61:Pro_isomerase
60:
56:
51:
45:
41:
36:
32:
27:
22:
17:
2099:Translocases
2096:
2083:
2070:
2057:
2044:
2034:Transferases
2031:
2018:
1875:Binding site
1803:
1515:
1423:Co-receptors
1376:MHC class II
1063:Cyclophilins
1027:
1023:
1013:
1002:
970:(10): e888.
967:
963:
953:
926:
922:
912:
879:
875:
868:
831:
827:
817:
780:
776:
766:
725:
721:
715:
682:
678:
672:
645:
641:
631:
596:
592:
582:
560:(9): 272–6.
557:
553:
547:
524:
520:adding to it
515:
491:
479:
466:
458:mitochondria
438:mitochondria
431:
419:
369:
288:
256:
243:
239:
200:Cyclophilins
199:
198:
1870:Active site
1804:Cyclophilin
1371:MHC class I
1267:Co-receptor
1130:Epsilon (ε)
1121:Fc receptor
494:cyclosporin
403:calcineurin
399:phosphatase
397:-dependent
379:beta barrel
208:ciclosporin
53:Identifiers
35:ciclosporin
2153:Isomerases
2142:Categories
2073:Isomerases
2047:Hydrolases
1914:Regulation
1717:Isomerases
1275:stimulate:
539:References
482:metastasis
462:cell death
395:calmodulin
387:beta-sheet
151:structures
1952:EC number
1721:geometric
1214:Secretory
1159:Gamma (γ)
450:cytosolic
411:TNF alpha
259:cytosolic
228:catalyzes
216:rejection
109:PDOC00154
97:IPR002130
2148:EC 5.2.1
1976:Kinetics
1900:Cofactor
1863:Activity
1809:Parvulin
1562:KIR2DL5B
1557:KIR2DL5A
1299:inhibit:
1182:Neonatal
1046:25048953
994:24176846
945:21205213
896:15718386
860:21173147
809:15792954
707:13160331
623:30435500
574:14731520
476:Diseases
377:, has a
279:secreted
271:isoforms
263:isozymes
246:form at
242:form to
204:proteins
168:RCSB PDB
92:InterPro
47:.
2132:Biology
2086:Ligases
1856:Enzymes
1802:other:
1607:KIR3DS1
1602:KIR3DL3
1597:KIR3DL2
1592:KIR3DL1
1587:KIR2DS5
1582:KIR2DS4
1577:KIR2DS3
1572:KIR2DS2
1567:KIR2DS1
1552:KIR2DL4
1547:KIR2DL3
1542:KIR2DL2
1537:KIR2DL1
1481:ζ-chain
1358:Ligands
1349:T cells
1242:B cells
1177:FcγRIII
985:3920964
904:8352110
851:3057831
758:4371206
750:7969495
730:Bibcode
699:7526121
664:8404888
615:1464374
593:FASEB J
391:calcium
375:cytosol
248:proline
104:PROSITE
72:PF00160
2118:Portal
2060:Lyases
1791:FKBP10
1751:FKBP1B
1746:FKBP1A
1675:LILRB5
1670:LILRB4
1665:LILRB3
1660:LILRB2
1655:LILRB1
1650:LILRA6
1645:LILRA5
1640:LILRA4
1635:LILRA3
1630:LILRA2
1625:LILRA1
1205:Fcα/μR
1172:FcγRII
1144:FcεRII
1069:(MeSH)
1044:
992:
982:
943:
923:FEBS J
902:
894:
858:
848:
807:
756:
748:
722:Nature
705:
697:
662:
621:
613:
572:
434:matrix
385:and a
343:PPIAL4
183:PDBsum
157:
147:
129:SUPFAM
85:CL0475
58:Symbol
2012:Types
1796:FKBPL
1786:FKBP9
1781:FKBP8
1776:FKBP6
1771:FKBP5
1766:FKBP4
1761:FKBP3
1756:FKBP2
1734:5.2.1
1200:FcαRI
1167:FcγRI
1138:FcεRI
900:S2CID
754:S2CID
703:S2CID
619:S2CID
422:HIV-1
352:PPWD1
347:PPIL6
339:PPIL4
335:PPIL3
331:PPIL2
327:PPIL1
240:trans
238:from
125:SCOPe
116:SCOP2
2104:list
2097:EC7
2091:list
2084:EC6
2078:list
2071:EC5
2065:list
2058:EC4
2052:list
2045:EC3
2039:list
2032:EC2
2026:list
2019:EC1
1742:FKBP
1727:5.2)
1516:see
1489:TCRζ
1487:and
1485:CD3ζ
1476:CD3ε
1471:CD3δ
1466:CD3γ
1439:CD8β
1437:and
1435:CD8α
1413:TRG@
1408:TRD@
1403:TRB@
1398:TRA@
1334:CD79
1330:Ig-β
1326:Ig-α
1306:CD22
1290:CD81
1286:CD19
1282:CD21
1042:PMID
990:PMID
941:PMID
892:PMID
856:PMID
805:PMID
746:PMID
695:PMID
660:PMID
611:PMID
570:PMID
413:and
322:PPIH
318:PPIG
314:PPIF
310:PPIE
306:PPID
302:PPIC
298:PPIB
294:PPIA
230:the
176:PDBj
172:PDBe
155:ECOD
145:Pfam
121:1cyh
81:clan
79:Pfam
67:Pfam
44:1CWA
1461:CD3
1445:CD4
1431:CD8
1394:TCR
1366:MHC
1257:BCR
1146:is
1032:doi
980:PMC
972:doi
931:doi
927:278
884:doi
880:289
846:PMC
836:doi
832:286
795:hdl
785:doi
781:280
738:doi
726:372
687:doi
650:doi
646:216
601:doi
562:doi
522:.
436:of
312:,
244:cis
234:of
163:PDB
40:PDB
2144::
1744::
1725:EC
1719::
1396::
1106::
1040:.
1028:61
1026:.
1022:.
988:.
978:.
966:.
962:.
939:.
925:.
921:.
898:.
890:.
878:.
854:.
844:.
830:.
826:.
803:.
793:.
779:.
775:.
752:.
744:.
736:.
724:.
701:.
693:.
683:10
681:.
658:.
644:.
640:.
617:.
609:.
595:.
591:.
568:.
556:.
417:.
401:,
345:,
341:,
337:,
333:,
329:,
320:,
316:,
308:,
304:,
300:,
296:,
281:.
254:.
174:;
170:;
153:/
127:/
123:/
42::
2120::
2106:)
2102:(
2093:)
2089:(
2080:)
2076:(
2067:)
2063:(
2054:)
2050:(
2041:)
2037:(
2028:)
2024:(
1848:e
1841:t
1834:v
1723:(
1709:e
1702:t
1695:v
1491:)
1441:)
1336:)
1332:(
1328:/
1288:/
1284:/
1150:)
1142:(
1096:e
1089:t
1082:v
1048:.
1034::
996:.
974::
968:4
947:.
933::
906:.
886::
862:.
838::
811:.
797::
787::
760:.
740::
732::
709:.
689::
666:.
652::
625:.
603::
597:6
576:.
564::
558:2
529:)
525:(
393:/
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