1585:/ERK1-2. In macrophages, CYR61 also activates the transcription factor NFκB and stimulates M1 polarization. CYR61 activates Akt signaling in thymic epithelial cells, promoting their proliferation and thus thymic size growth. CYR61 has potent angiogenic activity upon endothelial cells and induces neovascularization, first demonstrated in a corneal micropocket implant assay and subsequently confirmed in a rabbit ischemic hindlimb model. CYR61 also accelerates and promotes the chondrogenic differentiation of mouse limb bud mesenchymal cells, and stimulates osteoblast differentiation but inhibits osteoclastogenesis. Cyr61 is a strong inducer of reactive oxygen species accumulation in fibroblastic cells, and this activity underlies many CYR61-induced apoptosis and senescence. CYR61 is able to support
317:
294:
191:
216:
568:
575:
1517:
323:
222:
1549:, and αDβ2 in macrophage foam cells. Where examined, syndecan-4 has been identified as the HSPG critical for CCN1 functions. The CYR61 binding sites for some of these integrins have been mapped (Figure 1). Due to the cell type specificity of integrin expression, CYR61 acts through distinct integrins to mediate specific functions in different types of cells. For example, CYR61 induces
1656:
sufficiently high level to drive the myofibroblasts themselves into senescence, whereupon these cells cease to proliferate and express matrix-degrading enzymes. Thus, CYR61 limits synthesis and deposition of ECM by myofibroblasts, reducing the risk of fibrosis during wound healing. In addition to skin wound healing, CYR61 expression is elevated in remodeling cardiomyocytes after
40:
1790:
However, CYR61 can also induce apoptosis and cellular senescence, two well-established mechanisms of tumor suppression Thus, whereas CYR61 can promote the proliferation of prostate cancer cells, it can also exacerbate apoptosis of these cells in the presence of the immune surveillance molecule TRAIL.
1712:
CYR61 is highly expressed in collagen-induced arthritis in rodents, and inhibition of CCN1 expression correlates with suppression of inflammatory arthritis. CYR61 is also found in articular cartilage from patients with osteoarthritis and appears to suppress ADAMTS4 (aggrecanase) activity, possibly
1508:
residue content (10% or 38 in total). The number and spacing of cysteine residues are completely conserved among CYR61 (CCN1), CTGF (CCN2), NOV (CCN3), and WISP-1 (CCN4), and are largely conserved with WISP-2 (CCN5), which lacks precisely the CT domain, and WISP3 (CCN6), which lacks 4 cysteines in
1655:
to maintain tissue integrity and to promote regeneration of parenchymal cells. However, excessive matrix deposition can lead to fibrosis, scarring, and loss of tissue function. In skin wounds, CYR61 accumulates in the granulation tissue as myofibroblasts proliferate, and eventually reaches a
3918:
Sawai K, Mukoyama M, Mori K, Kasahara M, Koshikawa M, Yokoi H, Yoshioka T, Ogawa Y, Sugawara A, Nishiyama H, Yamada S, Kuwahara T, Saleem MA, Shiota K, Ogawa O, Miyazato M, Kangawa K, Nakao K (October 2007). "Expression of CCN1 (CYR61) in developing, normal, and diseased human kidney".
66:
1660:, in vascular injury, and in the long bones during fracture repair. Blockade of CYR61 by antibodies inhibits bone fracture healing in mice. In the kidney, CYR61 is expressed in podocytes in normal adult and embryonic glomeruli, but expression is decreased in
1741:
after balloon angioplasty, an effect that is reversed by delivery of CYR61 via gene transfer In a mouse model of oxygen-induced retinopathy, expression of CYR61 in the vitreous humor produced significant beneficial effects in repairing damaged vasculature.
1311:. Other highly conserved homologs were later identified to comprise the CCN protein family (CCN intercellular signaling protein). The CCN acronym is derived from the first three members of the family identified, namely CYR61 (CCN1),
4262:
Chijiiwa M, Mochizuki S, Kimura T, Abe H, Tanaka Y, Fujii Y, Shimizu H, Enomoto H, Toyama Y, Okada Y (June 2015). "CCN1 (Cyr61) Is
Overexpressed in Human Osteoarthritic Cartilage and Inhibits ADAMTS-4 (Aggrecanase 1) Activity".
4226:
Kok SH, Hou KL, Hong CY, Wang JS, Liang PC, Chang CC, Hsiao M, Yang H, Lai EH, Lin SK (April 2011). "Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: a therapeutic benefit for arthritis".
2667:"Identification of integrin αMβ2 as an adhesion receptor on peripheral blood moncytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2), immediate-early gene products expressed in atherosclerotic lesions"
1750:
Angiogenesis is essential for the supply of oxygen and nutrients to nourish the growing tumor. CYR61 is a powerful angiogenic inducer in vivo, and it can also promote cancer cell proliferation, invasion, survival,
5269:
Sakamoto S, Yokoyama M, Aoki M, Suzuki K, Kakehi Y, Saito Y (2004). "Induction and function of CYR61 (CCN1) in prostatic stromal and epithelial cells: CYR61 is required for prostatic cell proliferation".
1704:. CYR61 supports the patrolling behavior of murine resident Ly6C monocytes along the endothelial in the steady state and is required for their accumulation under viral-mimicking vascular inflammation.
4492:"The matricellular protein cysteine-rich protein 61 (CCN1/Cyr61) enhances physiological adaptation of retinal vessels and reduces pathological neovascularization associated with ischemic retinopathy"
4390:"Forkhead transcription factor FOXO3a is a negative regulator of angiogenic immediate early gene CYR61, leading to inhibition of vascular smooth muscle cell proliferation and neointimal hyperplasia"
4929:
Xie D, Nakachi K, Wang H, Elashoff R, Koeffler HP (2001). "Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features".
1593:, promote growth factor-induced cell proliferation and differentiation in some cell types, promote apoptosis in synergy with TNF family cytokines, and induce cellular senescence in fibroblasts.
4859:
Kok SH, Chang HH, Tsai JY, Hung HC, Lin CY, Chiang CP, Liu CM, Kuo MY (2010). "Expression of Cyr61 (CCN1) in human oral squamous cell carcinoma: An independent marker for poor prognosis".
1779:
cells. Clinically, CYR61 expression correlates with the tumor stage, tumor size, lymph node positivity, and poor prognosis in several cancers, including breast cancer, prostate cancer,
3869:"Vascular endothelial growth factor (VEGF)-induced up-regulation of CCN1 in osteoblasts mediates proangiogenic activities in endothelial cells and promotes fracture healing"
3169:
Fataccioli V, Abergel V, Wingertsmann L, Neuville P, Spitz E, Adnot S, Calenda V, Teiger E (2002). "Stimulation of angiogenesis by cyr61 gene: a new therapeutic candidate".
1496:
secretory signal peptide followed by four structurally distinct domains. The four CYR61 domains are, from N- to C-termini, the insulin-like growth factor binding protein (
1331:(CCN6) comprise the six members of the family in vertebrates and have been renamed CCN1-6 in order of their discovery by international consensus. CCN proteins function as
3419:"Promoter Function of the Angiogenic Inducer Cyr61 Gene in Transgenic Mice: Tissue Specificity, Inducibility During Wound Healing, and Role of the Serum Response Element"
2582:"The angiogenic factor CYR61 supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin α6β1 and cell surface heparan sulfate proteoglycans"
3055:
Emre, Yalin; Irla, Magali; Dunand-Sauthier, Isabelle; Ballet, Romain; Meguenani, Mehdi; Jemelin, Stephane; Vesin, Christian; Reith, Walter; Imhof, Beat A. (2013-11-27).
330:
229:
1609:
are embryonic lethal due to defects in cardiac septal morphogenesis, deficient blood vessel formation in placenta, and compromised vascular integrity. In
1497:
1271:
receptors and heparan sulfate proteoglycans. During embryonic development, CYR61 is critical for cardiac septal morphogenesis, blood vessel formation in
963:
4902:
Tsai MS, Hornby AE, Lakins J, Lupu R (2000). "Expression and function of CYR61, an angiogenic factor, in breast cancer cell lines and tumor biopsies".
3247:"CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells"
1631:
CYR61 is highly expressed at sites of inflammation and wound repair, and is associated with diseases involving chronic inflammation and tissue injury.
944:
152:
4349:"Heregulin, cysteine rich-61 and matrix metalloproteinase 9 expression in human carotid atherosclerotic plaques: relationship with clinical data"
1504:) domain, thrombospondin type 1 repeat domain (TSR), and the C-terminal (CT) domain that contains a cysteine-knot motif. CCN1 has unusually high
1435:
structure. Transcriptional activation of CYR61 is exquisitely sensitive to a wide range of environmental perturbations, including stimulation by
2623:"Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/Mouse connective tissue growth factor is mediated through integrin αIIbβ3"
1752:
1879:
1861:
1259:). CYR61 is capable of regulating a broad range of cellular activities, including cell adhesion, migration, proliferation, differentiation,
5451:
5397:"Silencing cAMP-response element binding protein (CREB) identifies cysteine-rich protein 61 (CYR61) as a tumor suppressor gene in melanoma"
1452:
1696:. It also reprograms macrophages towards M1 polarization through αMβ2-mediated activation of NF-κB. CYR61 is upregulated in patients with
5138:"Cyr61 induces gastric cancer cell motility/invasion via activation of the integrin/nuclear factor-κB/cyclooxygenase-2 signaling pathway"
1501:
1256:
316:
3830:"Expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24) during fracture healing"
1170:
1163:
293:
1355:
22.3, whereas the mouse Cyr61 gene is located at chromosome 3, 72.9cM. The mouse CYR61 coding region spans ~3.2 Kb, containing 5
3206:"Cyr61, product of a growth factor-inducible immediate-early gene, regulates chondrogenesis in mouse limb bud mesenchymal cells"
2495:"Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin αvβ3"
5461:
4159:
Imhof, Beat A.; Jemelin, Stephane; Ballet, Romain; Vesin, Christian; Schapira, Marco; Karaca, Melis; Emre, Yalin (2016-08-01).
3748:"Regulation of proangiogenic factor CCN1 in cardiac muscle: impact of ischemia, pressure overload, and neurohumoral activation"
1848:
1827:
1404:
1372:
4347:
Sigala F, Georgopoulos S, Papalambros E, Chasiotis D, Vourliotakis G, Niforou A, Kotsinas A, Kavantzas N, Patsouris E (2006).
2536:"Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin α6β1 and cell surface heparan sulfate proteoglycans"
2919:"Proangiogenic activities of CYR61 (CCN1) mediated through integrins αvβ3 and α6β1 in human umbilical vein endothelial cells"
2409:
Zhang Y, Diao Z, Su L, Sun H, Li R, Cui H, Hu Y (2010). "MicroRNA-155 contributes to preeclampsia by down-regulating CYR61".
1456:
1440:
1436:
1364:
4722:"Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis"
1844:
215:
190:
63:
3337:"CYR61 regulates BMP-2-dependent osteoblast differentiation through the αvβ3 integrin/integrin-linked kinase/ERK pathway"
1823:
5456:
5179:"Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines"
132:
2967:"The Matricellular Protein CCN1/CYR61 Induces Fibroblast Senescence and Restricts Fibrosis in Cutaneous Wound Healing"
1400:
3867:
Athanasopoulos AN, Schneider D, Keiper T, Alt V, Pendurthi UR, Liegibel UM, Sommer U, Nawroth PP, Kasperk C (2007).
2762:"Integrin αDβ2, an adhesion receptor up-regulated on macrophage foam cells, exhibits multiligand-binding properties"
1565:
through binding to α6β1-HSPGs. However, CYR61 supports cell adhesion through all of the integrins identified above.
329:
228:
4308:"Expression of CYR61, an angiogenic immediate early gene, in arteriosclerosis and its regulation by angiotensin II"
1792:
4306:
Hilfiker A, Hilfiker-Kleiner D, Fuchs M, Kaminski K, Lichtenberg A, Rothkotter HJ, Schieffer B, Drexler H (2002).
3057:"Thymic epithelial cell expansion through matricellular protein CYR61 boosts progenitor homing and T-cell output"
322:
221:
4578:"CYR61 and αVβ5 Integrin Cooperate to Promote Invasion and Metastasis of Tumors Growing in Preirradiated Stroma"
3746:
Hilfiker-Kleiner D, Kaminski K, Kaminska A, Fuchs M, Klein G, Podewski E, Grote K, Kiian I, Wollert KC (2004).
1424:
1008:
140:
4673:"Genomic and phenotypic analysis reveals a key role for CCN1 (CYR61) in BAG3-modulated adhesion and invasion"
989:
4720:
Haque I, Mehta S, Majumder M, Dhar K, De A, McGregor D, Van
Veldhuizen PJ, Banerjee SK, Banerjee S (2011).
4059:"The Matrix Protein CCN1 is Critical for Prostate Carcinoma Cell Proliferation and TRAIL-Induced Apoptosis"
4007:"Fas-Mediated Apoptosis is Regulated by the Extracellular Matrix Protein CCN1 (CYR61) in vitro and in vivo"
4576:
Monnier Y, Farmer P, Bieler G, Imaizumi N, Sengstag T, Alghisi GC, Stehle JC, Ciarloni L, Blant S (2008).
4389:
3109:"CYR61, product of a growth factor-inducible immediate-early gene, promotes angiogenesis and tumor growth"
1784:
1738:
1669:
4490:
Hasan A, Pokeza N, Shaw L, Lee HS, Lazzaro D, Chintala H, Rosenbaum D, Grant MB, Chaqour B (March 2011).
3296:"The matricellular protein CYR61 inhibits osteoclastogenesis by a mechanism independent of αvβ3 and αvβ5"
5466:
1657:
1574:
1428:
1332:
1238:
4817:"Ovarian carcinomas: CCN genes are aberrantly expressed and CCN1 promotes proliferation of these cells"
4776:"Breast cancer. Cyr61 is overexpressed, estrogen-inducible, and associated with more advanced disease"
4439:
Matsumae H, Yoshida Y, Ono K, Togi K, Inoue K, Furukawa Y, Nakashima Y, Kojima Y, Nobuyoshi M (2008).
2235:
Brigstock DR, Goldschmeding R, Katsube KI, Lam SC, Lau LF, Lyons K, Naus C, Perbal B, Riser B (2003).
4172:
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3120:
3068:
1665:
1652:
1396:
1336:
1280:
1252:
204:
5089:"Cyr61 mediates hepatocyte growth factor-dependent tumor cell growth, migration, and Akt activation"
123:, GIG1, IGFBP10, cysteine rich angiogenic inducer 61, cellular communication network factor 1, CYR61
119:
4112:"Substance P-mediated expression of the pro-angiogenic factor CCN1 modulates the course of colitis"
3960:
3789:"Temporal expression of the chondrogenic and angiogenic growth factor CYR61 during fracture repair"
3016:"The angiogenic factors Cyr61 and CTGF induce adhesive signaling in primary human skin fibroblasts"
2713:"The matricellular protein CCN1 activates a pro-inflammatory genetic program in murine macrophages"
2665:
Schober JM, Chen N, Grzeszkiewicz TM, Emeson EE, Ugarova TP, Ye RD, Lau LF, Lam SC, Lam SC (2002).
1734:
1673:
1554:
1388:
3828:
Nakata E, Nakanishi T, Kawai A, Asaumi K, Yamaai T, Asano M, Nishida T, Mitani S, Inoue H (2002).
2284:
Bornstein P, Sage EH (2002). "Matricellular proteins: extracellular modulators of cell function".
5295:
5251:
4884:
4288:
3630:
1796:
1776:
1701:
1644:
164:
2046:"Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells"
1697:
1146:
1125:
1099:
1078:
4671:
Kassis JN, Virador VM, Guancial EA, Kimm D, Ho AS, Mishra M, Chuang EY, Cook J, Gius D (2009).
3417:
Latinkic BV, Mo FE, Greenspan JA, Copeland NG, Gilbert DJ, Jenkins NA, Ross SR, Lau LF (2001).
5428:
5377:
5336:
5287:
5243:
5208:
5159:
5118:
5069:
5020:
4979:
4958:"Differential expression of the CCN family members Cyr61, CTGF and Nov in human breast cancer"
4938:
4911:
4876:
4838:
4797:
4774:
Xie D, Miller CW, O'Kelly J, Nakachi K, Sakashita A, Said JW, Gornbein J, Koeffler HP (2001).
4753:
4702:
4653:
4599:
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4523:
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4421:
4370:
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2301:
2266:
2217:
2165:
2116:
2075:
2026:
1972:
1920:
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1530:
1476:
1371:. The remaining four exons each encode a distinct CCN1 domain. The 5th exon also contains the
1279:
and tissue repair, and is associated with diseases related to chronic inflammation, including
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112:
56:
5418:
5408:
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5279:
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4643:
4635:
4589:
4550:
4513:
4503:
4462:
4452:
4411:
4401:
4360:
4319:
4272:
4236:
4198:
4180:
4161:"CCN1/CYR61-mediated meticulous patrolling by Ly6Clow monocytes fuels vascular inflammation"
4131:
4123:
4078:
4070:
4026:
4018:
3977:
3969:
3928:
3890:
3880:
3841:
3800:
3759:
3718:
3710:
3669:
3661:
3614:
3569:
3528:
3520:
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3471:
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3348:
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3266:
3258:
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3128:
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2978:
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2773:
2732:
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2634:
2593:
2547:
2506:
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2418:
2381:
2373:
2332:
2293:
2256:
2248:
2207:
2199:
2155:
2147:
2106:
2095:"All in the CCN family: essential matricellular signaling modulators emerge from the bunker"
2065:
2057:
2016:
2008:
1962:
1954:
1910:
1416:
409:
340:
284:
239:
3386:
O'Brian TP, Lau LF (1992). "Expression of the Growth Factor-Inducible
Immediate Early Gene
2362:"Promoter function and structure of the growth factor-inducible immediate early gene cyr61"
574:
5038:
D'Antonio KB, Toubaji A, Albadine R, Mondul AM, Platz EA, Netto GJ, Getzenberg RH (2010).
4997:
O'Kelly J, Chung A, Lemp N, Chumakova K, Yin D, Wang HJ, Said J, Gui D, Miller CW (2008).
1768:
1737:, both in rodent models and in humans. Suppression of CYR61 expression results in reduced
1722:
1661:
1538:
1376:
1284:
384:
160:
5226:
Schmitt CA (2003). "Senescence, apoptosis and therapy--cutting the lifelines of cancer".
4554:
774:
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
5136:
Lin MT, Zuon CY, Chang CC, Chen ST, Chen CP, Lin BR, Wang MY, Jeng YM, Chang KJ (2005).
5040:"Extracellular matrix associated protein CYR61 is linked to prostate cancer development"
4176:
3610:
3597:
Gurtner GC, Werner S, Barrandon Y, Longaker MT (2008). "Wound repair and regeneration".
3124:
3072:
1672:, particularly in diseased kidneys with severe mesangial expansion. CYR61 induction of
17:
5423:
5396:
5203:
5178:
5113:
5088:
5064:
5039:
4748:
4721:
4697:
4648:
4623:
4518:
4491:
4441:"CCN1 Knockdown Suppresses Neointimal Hyperplasia in a Rat Artery Balloon Injury Model"
4406:
4324:
4307:
4203:
4160:
4136:
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4107:
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3747:
3723:
3698:
3674:
3649:
3556:
Latinkic BV, Mercurio S, Bennett B, Hirst EM, Xu Q, Lau LF, Mohun TJ, Smith JC (2003).
3533:
3524:
3508:
3363:
3336:
3335:
Su JL, Chiou J, Tang CH, Zhao M, Tsai CH, Chen PS, Chang YW, Chien MH, Peng CY (2010).
3271:
3246:
2991:
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2894:
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2838:
2813:
2786:
2761:
2737:
2712:
2261:
2236:
2212:
2187:
2160:
2135:
2061:
2021:
1996:
1967:
1942:
1611:
1590:
1516:
1472:
1448:
1368:
4815:
Gery S, Xie D, Yin D, Gabra H, Miller C, Wang H, Scott D, Yi WS, Popoviciu ML (2005).
4388:
Lee HY, Chung JW, Youn SW, Kim JY, Park KW, Koo BK, Oh BH, Park YB, Chaqour B (2007).
3845:
3484:
3459:
2470:
2445:
2386:
2361:
2321:"The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p"
2297:
2070:
2045:
1997:"Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets"
1899:"The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p"
1541:(HSPGs) in fibroblasts and smooth muscle cells αIIbβ3 in activated platelets, αMβ2 in
878:
873:
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843:
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3108:
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1640:
1620:
1606:
1586:
603:
5395:
Dobroff AS, Wang H, Melnikova VO, Villares GJ, Zigler M, Huang L, Bar-Eli M (2009).
5315:"Cyr61, a member of CCN family, is a tumor suppressor in non-small cell lung cancer"
5299:
4888:
4624:"Involvement of Cyr61 in growth, migration, and metastasis of prostate cancer cells"
3262:
5255:
1616:
1510:
1352:
1340:
1307:
CYR61 was first identified as a protein encoded by a serum-inducible gene in mouse
1276:
402:
181:
5354:
Chien W, Kumagai T, Miller CW, Desmond JC, Frank JM, Said JW, Koeffler HP (2004).
5154:
5137:
5104:
4833:
4816:
4594:
4577:
4074:
144:
2203:
1605:
is highly expressed in the cardiovascular, skeletal, and neuronal systems. Cyr61
168:
3932:
3805:
3788:
1897:
Jay P, Berge-Lefranc JL, Marsollier C, Mejean C, Taviaux S, Berta P (May 1997).
1884:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1866:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1534:
1296:
1292:
5055:
4457:
4440:
4365:
4348:
4127:
3294:
Crockett JC, Schutze N, Tosh D, Jatzke S, Duthie A, Jakob F, Rogers MJ (2007).
2777:
2422:
2151:
1791:
CYR61 has an inhibitory effect on some cancers, and suppresses tumor growth of
485:
5194:
5087:
Goodwin CR, Lal B, Zhou X, Ho S, Xia S, Taeger A, Murray J, Laterra J (2010).
3973:
3182:
2683:
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1958:
1756:
1730:
1550:
1546:
1493:
1460:
1316:
1308:
1264:
301:
198:
148:
4956:
Jiang WG, Watkins G, Fodstad O, Douglas-Jones A, Mokbel K, Mansel RE (2004).
4194:
3558:"Xenopus Cyr61 regulates gastrulation movements and modulates Wnt signalling"
2885:
2728:
2639:
2622:
2377:
5413:
4508:
4185:
3460:"CYR61 (CCN1) Is Essential for Placental Development and Vascular Integrity"
3435:
3418:
3353:
3245:
Si W, Kang Q, Luu HH, Park JK, Luo Q, Song WX, Jiang W, Luo X, Li X (2006).
3133:
2319:
Jay P, Berge-Lefranc JL, Marsollier C, Mejean C, Taviaux S, Berta P (1997).
1760:
1726:
1562:
1468:
1260:
908:
545:
423:
368:
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267:
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156:
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4706:
4657:
4639:
4603:
4562:
4527:
4476:
4425:
4374:
4333:
4284:
4248:
4212:
4145:
4092:
4040:
3991:
3940:
3904:
3885:
3853:
3814:
3773:
3732:
3683:
3626:
3583:
3542:
3493:
3444:
3372:
3321:
3280:
3222:
3205:
3190:
3090:
3041:
3032:
3015:
3000:
2944:
2935:
2918:
2903:
2847:
2795:
2746:
2692:
2648:
2607:
2561:
2552:
2535:
2511:
2494:
2430:
2337:
2320:
2305:
2270:
2221:
2169:
2120:
2030:
1976:
1915:
1898:
1444:
39:
3714:
3403:
3231:
3152:
2829:
2598:
2581:
2520:
2479:
2461:
2395:
2346:
2079:
1924:
1210:
1205:
5313:
Tong X, Xie D, O'Kelly J, Miller CW, Muller-Tidow C, Koeffler HP (2001).
4022:
3312:
3295:
2870:"Cytotoxicity of TNFα is regulated by Integrin-Mediated Matrix Signaling"
1800:
1684:
CYR61 promotes the apoptotic functions of inflammatory cytokines such as
1578:
1553:
functions in endothelial cells through αvβ3, and in fibroblasts promotes
1542:
1505:
1464:
1392:
1288:
1272:
1268:
1194:
1053:
1034:
5015:
4998:
4974:
4957:
3829:
3618:
2252:
5283:
4999:"Functional domains of CCN1 (Cyr61) regulate breast cancer progression"
4467:
4416:
3081:
3056:
1759:. Accordingly, forced overexpression of CYR61 enhanced tumor growth in
1685:
1558:
1420:
1384:
1319:(nephroblastoma overexpressed, or CCN3). These proteins, together with
1020:
975:
4872:
4688:
4276:
4240:
3665:
3574:
3557:
2111:
2094:
1275:, and vascular integrity. In adulthood CYR61 plays important roles in
89:
85:
4057:
Franzen CA, Chen CC, Todorovic V, Juric V, Monzon RI, Lau LF (2009).
3509:"The matricellular protein CCN1 is essential for cardiac development"
2446:"Expression of cyr61, a growth factor-inducible immediate-early gene"
1780:
1360:
1178:
930:
5239:
4672:
3390:
2982:
2012:
1513:, although the regulation and function of glycosylation are unknown.
1339:
proteins that play regulatory roles, particularly in the context of
2868:
Chen CC, Young JL, Monzon RI, Chen N, Todorovic V, Lau LF (2007).
2814:"The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts"
2188:"Functions and Mechanisms of Action of CCN Matricellular Proteins"
1693:
1515:
1432:
1412:
1328:
1324:
1320:
3458:
Mo FE, Muntean AG, Chen CC, Stolz DB, Watkins SC, Lau LF (2002).
893:
889:
1689:
1582:
1380:
1356:
1312:
1245:
136:
583:
2621:
Jedsadayanmata A, Chen CC, Kireeva ML, Lau LF, Lam SC (1999).
2136:"The CCN family of proteins: structure-function relationships"
1943:"CCN1/CYR61: the very model of a modern matricellular protein"
1573:
As a cell adhesive substrate, CYR61 induces the activation of
1408:
2580:
Grzeszkiewicz TM, Lindner V, Chen N, Lam SC, Lau LF (2002).
1533:
in a cell type-dependent manner, including integrin αvβ3 in
5356:"Cyr61 suppresses growth of human endometrial cancer cells"
3954:
Valentijn FA, Falke LL, Nguyen TQ, Goldschmeding R (2018).
1492:
Full-length CYR61 protein contains 381 amino acids with an
1721:
CYR61 is overexpressed in vascular smooth muscle cells of
1451:, the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (
839:
positive regulation of transcription by RNA polymerase II
3699:"Cellular senescence controls fibrosis in wound healing"
1676:
in the kidney is a potential therapy to limit fibrosis.
392:
4622:
Sun ZJ, Wang Y, Cai Z, Chen PP, Tong XJ, Xie D (2008).
3956:"Cellular senescence in the aging and diseased kidney"
1255:(ECM)-associated signaling protein of the CCN family (
3107:
Babic AM, Kireeva ML, Kolesnikova TV, Lau LF (1998).
557:
704:
positive regulation of ceramide biosynthetic process
3204:Wong M, Kireeva ML, Kolesnikova TV, Lau LF (1997).
1139:
1118:
1092:
1071:
1840:
1838:
1836:
1819:
1817:
1815:
1367:sequence and the first several amino acids in the
1713:leading to cartilage cell (chondrocyte) cloning.
1395:containing promoter, with binding sites for many
784:positive regulation of osteoblast differentiation
699:apoptotic process involved in heart morphogenesis
339:
238:
1315:(connective tissue growth factor, or CCN2), and
4165:Proceedings of the National Academy of Sciences
3650:"Cellular and molecular mechanisms of fibrosis"
2444:O'Brien TP, Yang GP, Sanders L, Lau LF (1990).
694:positive regulation of osteoblast proliferation
27:Protein-coding gene in the species Homo sapiens
1845:GRCm38: Ensembl release 89: ENSMUSG00000028195
849:positive regulation of cell-substrate adhesion
844:positive regulation of protein kinase activity
709:positive regulation of protein phosphorylation
4854:
4852:
4769:
4767:
4617:
4615:
4613:
4052:
4050:
3164:
3162:
3102:
3100:
2960:
2958:
2956:
2954:
2863:
2861:
2859:
2857:
2807:
2805:
2706:
2704:
2702:
2660:
2658:
2575:
2573:
2571:
2181:
2179:
764:positive regulation of phospholipase activity
8:
2812:Todorovic V, Chen CC, Hay N, Lau LF (2005).
1990:
1988:
1986:
1936:
1934:
819:positive regulation of BMP signaling pathway
794:positive regulation of cartilage development
3961:Journal of Cell Communication and Signaling
3787:Hadjiargyrou M, Ahrens W, Rubin CT (2000).
2760:Yakubenko VP, Yadav SP, Ugarova TP (2006).
1824:GRCh38: Ensembl release 89: ENSG00000142871
1651:, which proliferate and rapidly synthesize
809:positive regulation of cell differentiation
739:labyrinthine layer blood vessel development
642:extracellular matrix structural constituent
2134:Holbourn KP, Acharya KR, Perbal B (2008).
904:
879:positive regulation of bone mineralization
599:
380:
279:
176:
74:
5422:
5412:
5371:
5330:
5202:
5153:
5112:
5063:
5014:
4973:
4832:
4791:
4747:
4737:
4696:
4647:
4593:
4517:
4507:
4466:
4456:
4415:
4405:
4364:
4323:
4202:
4184:
4135:
4082:
4030:
3981:
3894:
3884:
3804:
3763:
3722:
3673:
3573:
3532:
3483:
3434:
3362:
3352:
3311:
3270:
3221:
3142:
3132:
3080:
3031:
2990:
2934:
2893:
2837:
2785:
2736:
2682:
2638:
2597:
2551:
2510:
2469:
2385:
2336:
2260:
2237:"Proposal for a unified CCN nomenclature"
2211:
2159:
2110:
2069:
2020:
1966:
1914:
1500:) domain, von Willebrand type C repeats (
1431:, and 2 poly(CA) stretches that may form
744:reactive oxygen species metabolic process
2360:Latinkic BV, O'Brien TP, Lau LF (1991).
824:positive regulation of apoptotic process
734:negative regulation of apoptotic process
678:collagen-containing extracellular matrix
4106:Koon HW, Zhao D, Xu H, Bowe C, Moss A,
1811:
1299:, and many different forms of cancers.
854:post-translational protein modification
1267:through interaction with cell surface
29:
719:positive regulation of cell migration
344:
305:
300:
243:
202:
197:
7:
4555:10.1146/annurev.med.57.121304.131306
1479:, UV light, and mechanical stretch.
789:atrioventricular valve morphogenesis
496:endothelial cell of lymphatic vessel
2493:Kireeva ML, Lam SC, Lau LF (1998).
1643:, CYR61 is highly expressed in the
1601:During embryo development in mice,
1581:, RAC, and sustained activation of
1257:CCN intercellular signaling protein
1223:Cysteine-rich angiogenic inducer 61
814:regulation of ERK1 and ERK2 cascade
4541:Folkman J (2006). "Angiogenesis".
4407:10.1161/01.RES.0000257945.97958.77
4325:10.1161/01.CIR.0000021426.87274.62
3765:10.1161/01.CIR.0000127952.90508.9D
3525:10.1161/01.RES.0000248426.35019.89
2062:10.1002/j.1460-2075.1985.tb04057.x
1136:
1115:
1089:
1068:
1044:
1025:
999:
980:
954:
935:
724:anatomical structure morphogenesis
617:insulin-like growth factor binding
562:
480:
418:
397:
25:
4005:Juric V, Chen CC, Lau LF (2009).
3392:Cell Growth & Differentiation
1753:epithelial–mesenchymal transition
1443:, transforming growth factor β1 (
1375:sequences, which has 5 copies of
1241:that in humans is encoded by the
869:negative regulation of cell death
834:wound healing, spreading of cells
729:extracellular matrix organization
4445:Arterioscler. Thromb. Vasc. Biol
3476:10.1128/MCB.22.24.8709-8720.2002
3014:Chen CC, Chen N, Lau LF (2001).
2534:Chen N, Chen CC, Lau LF (2000).
1995:Jun JI, Lau LF (December 2011).
1529:CYR61 binds directly to various
573:
566:
328:
321:
315:
292:
227:
220:
214:
189:
38:
3263:10.1128/MCB.26.8.2955-2964.2006
2917:Leu SJ, Lam SC, Lau LF (2002).
2711:Bai T, Chen CC, Lau LF (2010).
2286:Current Opinion in Cell Biology
1787:, and squamous cell carcinoma.
1615:, Cyr61 is required for normal
1483:Protein structure and function
1441:basic fibroblast growth factor
1437:platelet-derived growth factor
714:ventricular septum development
584:More reference expression data
546:More reference expression data
1:
5155:10.1158/1078-0432.CCR-04-2639
5105:10.1158/0008-5472.CAN-09-3570
4834:10.1158/1078-0432.CCR-05-0231
4595:10.1158/0008-5472.CAN-08-0841
4075:10.1158/1541-7786.MCR-09-0017
3921:Am. J. Physiol. Renal Physiol
3846:10.1016/S8756-3282(02)00846-3
2298:10.1016/S0955-0674(02)00361-7
2001:Nature Reviews Drug Discovery
1539:heparan sulfate proteoglycans
1347:Gene structure and regulation
829:cell population proliferation
512:tunica media of zone of aorta
313:
212:
4353:Eur. J. Vasc. Endovasc. Surg
4265:Arthritis & Rheumatology
3113:Proc. Natl. Acad. Sci. U.S.A
2204:10.1016/j.biocel.2008.07.025
2093:Leask A, Abraham DJ (2006).
779:intussusceptive angiogenesis
754:chondroblast differentiation
627:extracellular matrix binding
5452:Genes on human chromosome 1
3933:10.1152/ajprenal.00205.2007
3806:10.1359/jbmr.2000.15.6.1014
1569:Cell signaling and function
769:atrial septum morphogenesis
673:endoplasmic reticulum lumen
5483:
5056:10.1016/j.juro.2009.12.006
4458:10.1161/ATVBAHA.108.162362
4366:10.1016/j.ejvs.2006.01.026
4128:10.2353/ajpath.2008.080222
2778:10.1182/blood-2005-06-2509
2423:10.1016/j.ajog.2010.01.057
2192:Int. J. Biochem. Cell Biol
2152:10.1016/j.tibs.2008.07.006
2044:Lau LF, Nathans D (1985).
1797:endometrial adenocarcinoma
1793:non-small-cell lung cancer
1635:Wound healing and fibrosis
1351:CYR61 is located at human
804:osteoblast differentiation
5195:10.1007/s12079-009-0080-4
3974:10.1007/s12079-017-0434-2
3183:10.1089/10430340260185094
2684:10.1182/blood.V99.12.4457
1959:10.1007/s00018-011-0778-3
1880:"Mouse PubMed Reference:"
1862:"Human PubMed Reference:"
1509:the vWC domain. CYR61 is
1363:. The first exon encodes
1209:
1204:
1200:
1193:
1177:
1171:Chr 3: 145.35 – 145.36 Mb
1158:
1143:
1122:
1111:
1096:
1075:
1064:
1051:
1047:
1032:
1028:
1019:
1006:
1002:
987:
983:
974:
961:
957:
942:
938:
929:
914:
907:
903:
887:
799:regulation of cell growth
602:
598:
581:
565:
556:
543:
492:
483:
430:
421:
391:
383:
379:
362:
349:
312:
291:
282:
278:
261:
248:
211:
188:
179:
175:
130:
127:
117:
110:
105:
82:
77:
60:
55:
50:
46:
37:
32:
5177:Chen CC, Lau LF (2010).
4110:, Pothoulakis C (2008).
3654:The Journal of Pathology
2886:10.1038/sj.emboj.7601596
2729:10.4049/jimmunol.0902792
2640:10.1074/jbc.274.34.24321
2186:Chen CC, Lau LF (2009).
1369:secretory signal peptide
18:Cysteine-rich protein 61
5414:10.1074/jbc.M109.019836
4509:10.1074/jbc.M110.198689
4186:10.1073/pnas.1607710113
3697:Jun JI, Lau LF (2010).
3436:10.1210/endo.142.6.8208
3354:10.1074/jbc.M109.087122
3134:10.1073/pnas.95.11.6355
2965:Jun JI, Lau LF (2010).
1941:Lau LF (October 2011).
1387:target site. The CYR61
1164:Chr 1: 85.58 – 85.58 Mb
749:chorio-allantoic fusion
5462:Aging-related proteins
5373:10.1074/jbc.M410254200
5332:10.1074/jbc.M107878200
5183:J. Cell Commun. Signal
4793:10.1074/jbc.M009755200
4739:10.1186/1476-4598-10-8
4640:10.1038/sj.bjc.6604712
3886:10.1074/jbc.M705200200
3507:Mo FE, Lau LF (2006).
3223:10.1006/dbio.1997.8766
3033:10.1074/jbc.M008087200
2936:10.1074/jbc.M209288200
2553:10.1074/jbc.M003040200
2512:10.1074/jbc.273.5.3090
2411:Am. J. Obstet. Gynecol
2378:10.1093/nar/19.12.3261
2338:10.1038/sj.onc.1200986
1916:10.1038/sj.onc.1200986
1785:gastric adenocarcinoma
1739:neointimal hyperplasia
1670:membranous nephropathy
1521:
1520:CCN1 Protein Structure
1333:matricellular proteins
5228:Nature Reviews Cancer
4962:Endocr. Relat. Cancer
3715:10.18632/aging.100201
3061:Nature Communications
2830:10.1083/jcb.200504015
2599:10.1210/en.143.4.1441
2462:10.1128/MCB.10.7.3569
1658:myocardial infarction
1597:Embryonic development
1575:focal adhesion kinase
1519:
1397:transcription factors
1379:that confers a short
1251:CYR61 is a secreted,
1239:matricellular protein
622:growth factor binding
500:stroma of bone marrow
462:right coronary artery
4023:10.1128/MCB.00064-09
3313:10.1210/en.2007-0473
2105:(Pt 23): 4803–4810.
1666:diabetic nephropathy
1337:extracellular matrix
1281:rheumatoid arthritis
1253:extracellular matrix
663:extracellular region
658:extracellular matrix
466:left coronary artery
438:smooth muscle tissue
346:3 H2|3 70.18 cM
307:Chromosome 3 (mouse)
205:Chromosome 1 (human)
78:List of PDB id codes
51:Available structures
5457:Aging-related genes
5407:(38): 26194–26206.
5366:(51): 53087–53096.
5325:(50): 47709–47714.
5016:10.3892/ijo.33.1.59
4975:10.1677/erc.1.00825
4786:(17): 14187–14194.
4177:2016PNAS..113E4847I
4171:(33): E4847–E4856.
3879:(37): 26746–26753.
3619:10.1038/nature07039
3611:2008Natur.453..314G
3347:(41): 31325–31336.
3125:1998PNAS...95.6355B
3073:2013NatCo...4.2842E
3026:(13): 10443–10452.
2929:(48): 46248–46255.
2633:(34): 24321–24327.
2546:(32): 24953–24961.
2253:10.1136/mp.56.2.127
2140:Trends Biochem. Sci
1947:Cell. Mol. Life Sci
1735:balloon angioplasty
1725:lesions and in the
1674:cellular senescence
1555:cellular senescence
1359:interspaced with 4
1231:CCN family member 1
864:cell-cell signaling
668:extracellular space
5284:10.1002/pros.20098
3793:J. Bone Miner. Res
3082:10.1038/ncomms3842
1777:squamous carcinoma
1702:ulcerative colitis
1645:granulation tissue
1627:Clinical relevance
1619:and modulation of
1531:integrin receptors
1522:
1488:Structural domains
1303:CCN protein family
1009:ENSMUSG00000028195
874:cell-cell adhesion
687:Biological process
651:Cellular component
610:Molecular function
458:lower lobe of lung
5148:(16): 5809–5820.
4937:(24): 8917–8923.
4910:(20): 5603–5607.
4873:10.1002/hed.21381
4867:(12): 1665–1673.
4827:(20): 7243–7254.
4689:10.1002/path.2557
4634:(10): 1656–1667.
4588:(18): 7323–7331.
4277:10.1002/art.39078
4241:10.1002/art.27433
4017:(12): 3266–3279.
3758:(18): 2227–2233.
3666:10.1002/path.2277
3605:(7193): 314–321.
3575:10.1242/dev.00449
3568:(11): 2429–2441.
3470:(24): 8709–8720.
3306:(12): 5761–5768.
3177:(12): 1461–1470.
3119:(11): 6355–6360.
2677:(12): 4457–4465.
2372:(12): 3261–3267.
2366:Nucleic Acids Res
2331:(14): 1753–1757.
2112:10.1242/jcs.03270
2056:(12): 3145–3151.
1773:ovarian carcinoma
1717:Vascular diseases
1383:half life, and a
1220:
1219:
1216:
1215:
1189:
1188:
1154:
1153:
1133:
1132:
1107:
1106:
1086:
1085:
1060:
1059:
1041:
1040:
1015:
1014:
996:
995:
970:
969:
951:
950:
899:
898:
594:
593:
590:
589:
552:
551:
539:
538:
477:
476:
434:left uterine tube
375:
374:
274:
273:
101:
100:
97:
96:
61:Ortholog search:
16:(Redirected from
5474:
5437:
5436:
5426:
5416:
5392:
5386:
5385:
5375:
5351:
5345:
5344:
5334:
5310:
5304:
5303:
5266:
5260:
5259:
5223:
5217:
5216:
5206:
5174:
5168:
5167:
5157:
5142:Clin. Cancer Res
5133:
5127:
5126:
5116:
5099:(7): 2932–2941.
5084:
5078:
5077:
5067:
5050:(4): 1604–1610.
5035:
5029:
5028:
5018:
4994:
4988:
4987:
4977:
4953:
4947:
4946:
4926:
4920:
4919:
4899:
4893:
4892:
4856:
4847:
4846:
4836:
4821:Clin. Cancer Res
4812:
4806:
4805:
4795:
4771:
4762:
4761:
4751:
4741:
4717:
4711:
4710:
4700:
4668:
4662:
4661:
4651:
4619:
4608:
4607:
4597:
4573:
4567:
4566:
4538:
4532:
4531:
4521:
4511:
4487:
4481:
4480:
4470:
4460:
4451:(6): 1077–1083.
4436:
4430:
4429:
4419:
4409:
4385:
4379:
4378:
4368:
4344:
4338:
4337:
4327:
4303:
4297:
4296:
4259:
4253:
4252:
4223:
4217:
4216:
4206:
4188:
4156:
4150:
4149:
4139:
4103:
4097:
4096:
4086:
4069:(7): 1045–1055.
4054:
4045:
4044:
4034:
4002:
3996:
3995:
3985:
3951:
3945:
3944:
3915:
3909:
3908:
3898:
3888:
3864:
3858:
3857:
3825:
3819:
3818:
3808:
3799:(6): 1014–1023.
3784:
3778:
3777:
3767:
3743:
3737:
3736:
3726:
3694:
3688:
3687:
3677:
3648:Wynn TA (2008).
3645:
3639:
3638:
3594:
3588:
3587:
3577:
3553:
3547:
3546:
3536:
3504:
3498:
3497:
3487:
3455:
3449:
3448:
3438:
3429:(6): 2549–2557.
3414:
3408:
3407:
3383:
3377:
3376:
3366:
3356:
3332:
3326:
3325:
3315:
3291:
3285:
3284:
3274:
3257:(8): 2955–2964.
3242:
3236:
3235:
3225:
3201:
3195:
3194:
3166:
3157:
3156:
3146:
3136:
3104:
3095:
3094:
3084:
3052:
3046:
3045:
3035:
3011:
3005:
3004:
2994:
2962:
2949:
2948:
2938:
2914:
2908:
2907:
2897:
2880:(5): 1257–1267.
2865:
2852:
2851:
2841:
2809:
2800:
2799:
2789:
2772:(4): 1643–1650.
2757:
2751:
2750:
2740:
2723:(6): 3223–3232.
2708:
2697:
2696:
2686:
2662:
2653:
2652:
2642:
2618:
2612:
2611:
2601:
2592:(4): 1441–1450.
2577:
2566:
2565:
2555:
2531:
2525:
2524:
2514:
2505:(5): 3090–3096.
2490:
2484:
2483:
2473:
2456:(7): 3569–3577.
2441:
2435:
2434:
2406:
2400:
2399:
2389:
2357:
2351:
2350:
2340:
2316:
2310:
2309:
2281:
2275:
2274:
2264:
2232:
2226:
2225:
2215:
2183:
2174:
2173:
2163:
2131:
2125:
2124:
2114:
2090:
2084:
2083:
2073:
2041:
2035:
2034:
2024:
1992:
1981:
1980:
1970:
1938:
1929:
1928:
1918:
1894:
1888:
1887:
1876:
1870:
1869:
1858:
1852:
1842:
1831:
1821:
1537:cells, α6β1 and
1525:Integrin binding
1377:AU-rich elements
1202:
1201:
1173:
1166:
1149:
1137:
1128:
1116:
1112:RefSeq (protein)
1102:
1090:
1081:
1069:
1045:
1026:
1000:
981:
955:
936:
905:
632:integrin binding
600:
586:
577:
570:
563:
548:
488:
486:Top expressed in
481:
426:
424:Top expressed in
419:
398:
381:
371:
358:
347:
332:
325:
319:
308:
296:
280:
270:
257:
246:
231:
224:
218:
207:
193:
177:
171:
169:CCN1 - orthologs
122:
115:
92:
75:
69:
48:
47:
42:
30:
21:
5482:
5481:
5477:
5476:
5475:
5473:
5472:
5471:
5442:
5441:
5440:
5394:
5393:
5389:
5353:
5352:
5348:
5312:
5311:
5307:
5268:
5267:
5263:
5240:10.1038/nrc1044
5225:
5224:
5220:
5176:
5175:
5171:
5135:
5134:
5130:
5086:
5085:
5081:
5037:
5036:
5032:
4996:
4995:
4991:
4955:
4954:
4950:
4928:
4927:
4923:
4901:
4900:
4896:
4858:
4857:
4850:
4814:
4813:
4809:
4773:
4772:
4765:
4719:
4718:
4714:
4670:
4669:
4665:
4621:
4620:
4611:
4575:
4574:
4570:
4540:
4539:
4535:
4502:(11): 9542–54.
4489:
4488:
4484:
4438:
4437:
4433:
4387:
4386:
4382:
4346:
4345:
4341:
4305:
4304:
4300:
4261:
4260:
4256:
4229:Arthritis Rheum
4225:
4224:
4220:
4158:
4157:
4153:
4105:
4104:
4100:
4063:Mol. Cancer Res
4056:
4055:
4048:
4011:Mol. Cell. Biol
4004:
4003:
3999:
3953:
3952:
3948:
3927:(4): F1363–72.
3917:
3916:
3912:
3866:
3865:
3861:
3827:
3826:
3822:
3786:
3785:
3781:
3745:
3744:
3740:
3696:
3695:
3691:
3647:
3646:
3642:
3596:
3595:
3591:
3555:
3554:
3550:
3506:
3505:
3501:
3464:Mol. Cell. Biol
3457:
3456:
3452:
3416:
3415:
3411:
3385:
3384:
3380:
3334:
3333:
3329:
3293:
3292:
3288:
3251:Mol. Cell. Biol
3244:
3243:
3239:
3203:
3202:
3198:
3168:
3167:
3160:
3106:
3105:
3098:
3054:
3053:
3049:
3013:
3012:
3008:
2983:10.1038/ncb2070
2964:
2963:
2952:
2916:
2915:
2911:
2867:
2866:
2855:
2811:
2810:
2803:
2759:
2758:
2754:
2710:
2709:
2700:
2664:
2663:
2656:
2620:
2619:
2615:
2579:
2578:
2569:
2533:
2532:
2528:
2492:
2491:
2487:
2450:Mol. Cell. Biol
2443:
2442:
2438:
2408:
2407:
2403:
2359:
2358:
2354:
2318:
2317:
2313:
2283:
2282:
2278:
2234:
2233:
2229:
2185:
2184:
2177:
2146:(10): 461–473.
2133:
2132:
2128:
2092:
2091:
2087:
2043:
2042:
2038:
2013:10.1038/nrd3599
1994:
1993:
1984:
1953:(19): 3149–63.
1940:
1939:
1932:
1896:
1895:
1891:
1878:
1877:
1873:
1860:
1859:
1855:
1843:
1834:
1822:
1813:
1809:
1795:(NSCLC) cells,
1769:prostate cancer
1748:
1723:atherosclerotic
1719:
1710:
1698:Crohn's disease
1682:
1662:IgA nephropathy
1637:
1629:
1599:
1571:
1527:
1490:
1485:
1349:
1305:
1285:atherosclerosis
1211:View/Edit Mouse
1206:View/Edit Human
1169:
1162:
1159:Location (UCSC)
1145:
1124:
1098:
1077:
990:ENSG00000142871
883:
682:
646:
637:heparin binding
582:
572:
571:
544:
535:
530:
526:
522:
518:
516:muscle of thigh
514:
510:
506:
502:
498:
484:
473:
468:
464:
460:
456:
452:
448:
444:
440:
436:
422:
366:
353:
345:
335:
334:
333:
326:
306:
283:Gene location (
265:
252:
244:
234:
233:
232:
225:
203:
180:Gene location (
131:
118:
111:
84:
62:
28:
23:
22:
15:
12:
11:
5:
5480:
5478:
5470:
5469:
5464:
5459:
5454:
5444:
5443:
5439:
5438:
5387:
5346:
5305:
5278:(4): 305–317.
5261:
5234:(4): 286–295.
5218:
5169:
5128:
5079:
5030:
4989:
4968:(4): 781–791.
4948:
4921:
4894:
4848:
4807:
4763:
4712:
4683:(4): 495–504.
4663:
4609:
4568:
4543:Annu. Rev. Med
4533:
4482:
4431:
4400:(3): 372–380.
4380:
4359:(3): 238–245.
4339:
4318:(2): 254–260.
4298:
4271:(6): 1557–67.
4254:
4235:(4): 1010–20.
4218:
4151:
4122:(2): 400–410.
4098:
4046:
3997:
3946:
3910:
3859:
3840:(4): 441–447.
3820:
3779:
3738:
3709:(9): 627–631.
3689:
3660:(2): 199–210.
3640:
3589:
3548:
3519:(9): 961–969.
3499:
3450:
3409:
3398:(9): 645–654.
3378:
3327:
3286:
3237:
3216:(2): 492–508.
3196:
3171:Hum. Gene Ther
3158:
3096:
3047:
3006:
2977:(7): 676–685.
2971:Nat. Cell Biol
2950:
2909:
2853:
2824:(3): 559–568.
2801:
2752:
2698:
2654:
2613:
2567:
2526:
2485:
2436:
2417:(5): 466–467.
2401:
2352:
2311:
2292:(5): 608–616.
2276:
2247:(2): 127–128.
2227:
2198:(4): 771–783.
2175:
2126:
2085:
2036:
2007:(12): 945–63.
1982:
1930:
1909:(14): 1753–7.
1889:
1871:
1853:
1832:
1810:
1808:
1805:
1799:cells, and in
1747:
1744:
1718:
1715:
1709:
1706:
1681:
1678:
1649:myofibroblasts
1636:
1633:
1628:
1625:
1612:Xenopus laevis
1598:
1595:
1591:cell migration
1570:
1567:
1526:
1523:
1489:
1486:
1484:
1481:
1473:angiotensin II
1449:growth hormone
1348:
1345:
1304:
1301:
1218:
1217:
1214:
1213:
1208:
1198:
1197:
1191:
1190:
1187:
1186:
1184:
1182:
1175:
1174:
1167:
1160:
1156:
1155:
1152:
1151:
1141:
1140:
1134:
1131:
1130:
1120:
1119:
1113:
1109:
1108:
1105:
1104:
1094:
1093:
1087:
1084:
1083:
1073:
1072:
1066:
1062:
1061:
1058:
1057:
1049:
1048:
1042:
1039:
1038:
1030:
1029:
1023:
1017:
1016:
1013:
1012:
1004:
1003:
997:
994:
993:
985:
984:
978:
972:
971:
968:
967:
959:
958:
952:
949:
948:
940:
939:
933:
927:
926:
921:
916:
912:
911:
901:
900:
897:
896:
885:
884:
882:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
690:
688:
684:
683:
681:
680:
675:
670:
665:
660:
654:
652:
648:
647:
645:
644:
639:
634:
629:
624:
619:
613:
611:
607:
606:
596:
595:
592:
591:
588:
587:
579:
578:
560:
554:
553:
550:
549:
541:
540:
537:
536:
534:
533:
529:
525:
521:
517:
513:
509:
505:
501:
497:
493:
490:
489:
478:
475:
474:
472:
471:
467:
463:
459:
455:
454:gastric mucosa
451:
450:saphenous vein
447:
443:
439:
435:
431:
428:
427:
415:
414:
406:
395:
389:
388:
385:RNA expression
377:
376:
373:
372:
364:
360:
359:
351:
348:
343:
337:
336:
327:
320:
314:
310:
309:
304:
298:
297:
289:
288:
276:
275:
272:
271:
263:
259:
258:
250:
247:
242:
236:
235:
226:
219:
213:
209:
208:
201:
195:
194:
186:
185:
173:
172:
129:
125:
124:
116:
108:
107:
103:
102:
99:
98:
95:
94:
80:
79:
71:
70:
59:
53:
52:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5479:
5468:
5465:
5463:
5460:
5458:
5455:
5453:
5450:
5449:
5447:
5434:
5430:
5425:
5420:
5415:
5410:
5406:
5402:
5401:J. Biol. Chem
5398:
5391:
5388:
5383:
5379:
5374:
5369:
5365:
5361:
5360:J. Biol. Chem
5357:
5350:
5347:
5342:
5338:
5333:
5328:
5324:
5320:
5319:J. Biol. Chem
5316:
5309:
5306:
5301:
5297:
5293:
5289:
5285:
5281:
5277:
5273:
5265:
5262:
5257:
5253:
5249:
5245:
5241:
5237:
5233:
5229:
5222:
5219:
5214:
5210:
5205:
5200:
5196:
5192:
5188:
5184:
5180:
5173:
5170:
5165:
5161:
5156:
5151:
5147:
5143:
5139:
5132:
5129:
5124:
5120:
5115:
5110:
5106:
5102:
5098:
5094:
5090:
5083:
5080:
5075:
5071:
5066:
5061:
5057:
5053:
5049:
5045:
5041:
5034:
5031:
5026:
5022:
5017:
5012:
5008:
5004:
5003:Int. J. Oncol
5000:
4993:
4990:
4985:
4981:
4976:
4971:
4967:
4963:
4959:
4952:
4949:
4944:
4940:
4936:
4932:
4925:
4922:
4917:
4913:
4909:
4905:
4898:
4895:
4890:
4886:
4882:
4878:
4874:
4870:
4866:
4862:
4855:
4853:
4849:
4844:
4840:
4835:
4830:
4826:
4822:
4818:
4811:
4808:
4803:
4799:
4794:
4789:
4785:
4781:
4780:J. Biol. Chem
4777:
4770:
4768:
4764:
4759:
4755:
4750:
4745:
4740:
4735:
4731:
4727:
4723:
4716:
4713:
4708:
4704:
4699:
4694:
4690:
4686:
4682:
4678:
4674:
4667:
4664:
4659:
4655:
4650:
4645:
4641:
4637:
4633:
4629:
4628:Br. J. Cancer
4625:
4618:
4616:
4614:
4610:
4605:
4601:
4596:
4591:
4587:
4583:
4579:
4572:
4569:
4564:
4560:
4556:
4552:
4548:
4544:
4537:
4534:
4529:
4525:
4520:
4515:
4510:
4505:
4501:
4497:
4496:J. Biol. Chem
4493:
4486:
4483:
4478:
4474:
4469:
4464:
4459:
4454:
4450:
4446:
4442:
4435:
4432:
4427:
4423:
4418:
4413:
4408:
4403:
4399:
4395:
4391:
4384:
4381:
4376:
4372:
4367:
4362:
4358:
4354:
4350:
4343:
4340:
4335:
4331:
4326:
4321:
4317:
4313:
4309:
4302:
4299:
4294:
4290:
4286:
4282:
4278:
4274:
4270:
4266:
4258:
4255:
4250:
4246:
4242:
4238:
4234:
4230:
4222:
4219:
4214:
4210:
4205:
4200:
4196:
4192:
4187:
4182:
4178:
4174:
4170:
4166:
4162:
4155:
4152:
4147:
4143:
4138:
4133:
4129:
4125:
4121:
4117:
4116:Am. J. Pathol
4113:
4109:
4102:
4099:
4094:
4090:
4085:
4080:
4076:
4072:
4068:
4064:
4060:
4053:
4051:
4047:
4042:
4038:
4033:
4028:
4024:
4020:
4016:
4012:
4008:
4001:
3998:
3993:
3989:
3984:
3979:
3975:
3971:
3967:
3963:
3962:
3957:
3950:
3947:
3942:
3938:
3934:
3930:
3926:
3922:
3914:
3911:
3906:
3902:
3897:
3892:
3887:
3882:
3878:
3874:
3873:J. Biol. Chem
3870:
3863:
3860:
3855:
3851:
3847:
3843:
3839:
3835:
3831:
3824:
3821:
3816:
3812:
3807:
3802:
3798:
3794:
3790:
3783:
3780:
3775:
3771:
3766:
3761:
3757:
3753:
3749:
3742:
3739:
3734:
3730:
3725:
3720:
3716:
3712:
3708:
3704:
3700:
3693:
3690:
3685:
3681:
3676:
3671:
3667:
3663:
3659:
3655:
3651:
3644:
3641:
3636:
3632:
3628:
3624:
3620:
3616:
3612:
3608:
3604:
3600:
3593:
3590:
3585:
3581:
3576:
3571:
3567:
3563:
3559:
3552:
3549:
3544:
3540:
3535:
3530:
3526:
3522:
3518:
3514:
3510:
3503:
3500:
3495:
3491:
3486:
3481:
3477:
3473:
3469:
3465:
3461:
3454:
3451:
3446:
3442:
3437:
3432:
3428:
3424:
3423:Endocrinology
3420:
3413:
3410:
3405:
3401:
3397:
3393:
3389:
3382:
3379:
3374:
3370:
3365:
3360:
3355:
3350:
3346:
3342:
3341:J. Biol. Chem
3338:
3331:
3328:
3323:
3319:
3314:
3309:
3305:
3301:
3300:Endocrinology
3297:
3290:
3287:
3282:
3278:
3273:
3268:
3264:
3260:
3256:
3252:
3248:
3241:
3238:
3233:
3229:
3224:
3219:
3215:
3211:
3207:
3200:
3197:
3192:
3188:
3184:
3180:
3176:
3172:
3165:
3163:
3159:
3154:
3150:
3145:
3140:
3135:
3130:
3126:
3122:
3118:
3114:
3110:
3103:
3101:
3097:
3092:
3088:
3083:
3078:
3074:
3070:
3066:
3062:
3058:
3051:
3048:
3043:
3039:
3034:
3029:
3025:
3021:
3020:J. Biol. Chem
3017:
3010:
3007:
3002:
2998:
2993:
2988:
2984:
2980:
2976:
2972:
2968:
2961:
2959:
2957:
2955:
2951:
2946:
2942:
2937:
2932:
2928:
2924:
2923:J. Biol. Chem
2920:
2913:
2910:
2905:
2901:
2896:
2891:
2887:
2883:
2879:
2875:
2871:
2864:
2862:
2860:
2858:
2854:
2849:
2845:
2840:
2835:
2831:
2827:
2823:
2819:
2815:
2808:
2806:
2802:
2797:
2793:
2788:
2783:
2779:
2775:
2771:
2767:
2763:
2756:
2753:
2748:
2744:
2739:
2734:
2730:
2726:
2722:
2718:
2714:
2707:
2705:
2703:
2699:
2694:
2690:
2685:
2680:
2676:
2672:
2668:
2661:
2659:
2655:
2650:
2646:
2641:
2636:
2632:
2628:
2627:J. Biol. Chem
2624:
2617:
2614:
2609:
2605:
2600:
2595:
2591:
2587:
2586:Endocrinology
2583:
2576:
2574:
2572:
2568:
2563:
2559:
2554:
2549:
2545:
2541:
2540:J. Biol. Chem
2537:
2530:
2527:
2522:
2518:
2513:
2508:
2504:
2500:
2499:J. Biol. Chem
2496:
2489:
2486:
2481:
2477:
2472:
2467:
2463:
2459:
2455:
2451:
2447:
2440:
2437:
2432:
2428:
2424:
2420:
2416:
2412:
2405:
2402:
2397:
2393:
2388:
2383:
2379:
2375:
2371:
2367:
2363:
2356:
2353:
2348:
2344:
2339:
2334:
2330:
2326:
2322:
2315:
2312:
2307:
2303:
2299:
2295:
2291:
2287:
2280:
2277:
2272:
2268:
2263:
2258:
2254:
2250:
2246:
2242:
2238:
2231:
2228:
2223:
2219:
2214:
2209:
2205:
2201:
2197:
2193:
2189:
2182:
2180:
2176:
2171:
2167:
2162:
2157:
2153:
2149:
2145:
2141:
2137:
2130:
2127:
2122:
2118:
2113:
2108:
2104:
2100:
2096:
2089:
2086:
2081:
2077:
2072:
2067:
2063:
2059:
2055:
2051:
2047:
2040:
2037:
2032:
2028:
2023:
2018:
2014:
2010:
2006:
2002:
1998:
1991:
1989:
1987:
1983:
1978:
1974:
1969:
1964:
1960:
1956:
1952:
1948:
1944:
1937:
1935:
1931:
1926:
1922:
1917:
1912:
1908:
1904:
1900:
1893:
1890:
1885:
1881:
1875:
1872:
1867:
1863:
1857:
1854:
1850:
1846:
1841:
1839:
1837:
1833:
1829:
1825:
1820:
1818:
1816:
1812:
1806:
1804:
1802:
1798:
1794:
1788:
1786:
1782:
1778:
1774:
1770:
1766:
1765:breast cancer
1762:
1758:
1754:
1745:
1743:
1740:
1736:
1732:
1728:
1724:
1716:
1714:
1707:
1705:
1703:
1699:
1695:
1691:
1687:
1679:
1677:
1675:
1671:
1667:
1663:
1659:
1654:
1650:
1646:
1642:
1641:wound healing
1634:
1632:
1626:
1624:
1622:
1621:Wnt signaling
1618:
1614:
1613:
1608:
1607:knockout mice
1604:
1596:
1594:
1592:
1588:
1587:cell adhesion
1584:
1580:
1576:
1568:
1566:
1564:
1560:
1556:
1552:
1548:
1544:
1540:
1536:
1532:
1524:
1518:
1514:
1512:
1507:
1503:
1499:
1495:
1487:
1482:
1480:
1478:
1474:
1470:
1466:
1462:
1458:
1454:
1450:
1446:
1442:
1438:
1434:
1430:
1426:
1422:
1418:
1414:
1410:
1406:
1402:
1398:
1394:
1390:
1386:
1382:
1378:
1374:
1370:
1366:
1362:
1358:
1354:
1353:chromosome 1p
1346:
1344:
1342:
1338:
1334:
1330:
1326:
1322:
1318:
1314:
1310:
1302:
1300:
1298:
1294:
1290:
1286:
1282:
1278:
1274:
1270:
1266:
1262:
1258:
1254:
1249:
1247:
1244:
1240:
1236:
1232:
1228:
1224:
1212:
1207:
1203:
1199:
1196:
1192:
1185:
1183:
1180:
1176:
1172:
1168:
1165:
1161:
1157:
1150:
1148:
1142:
1138:
1135:
1129:
1127:
1121:
1117:
1114:
1110:
1103:
1101:
1095:
1091:
1088:
1082:
1080:
1074:
1070:
1067:
1065:RefSeq (mRNA)
1063:
1056:
1055:
1050:
1046:
1043:
1037:
1036:
1031:
1027:
1024:
1022:
1018:
1011:
1010:
1005:
1001:
998:
992:
991:
986:
982:
979:
977:
973:
966:
965:
960:
956:
953:
947:
946:
941:
937:
934:
932:
928:
925:
922:
920:
917:
913:
910:
906:
902:
895:
891:
886:
880:
877:
875:
872:
870:
867:
865:
862:
860:
859:cell adhesion
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
691:
689:
686:
685:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
655:
653:
650:
649:
643:
640:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
614:
612:
609:
608:
605:
604:Gene ontology
601:
597:
585:
580:
576:
569:
564:
561:
559:
555:
547:
542:
531:
528:body of femur
527:
523:
519:
515:
511:
507:
503:
499:
495:
494:
491:
487:
482:
479:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
432:
429:
425:
420:
417:
416:
413:
411:
407:
405:
404:
400:
399:
396:
394:
390:
386:
382:
378:
370:
365:
361:
357:
352:
342:
338:
331:
324:
318:
311:
303:
299:
295:
290:
286:
281:
277:
269:
264:
260:
256:
251:
241:
237:
230:
223:
217:
210:
206:
200:
196:
192:
187:
183:
178:
174:
170:
166:
162:
158:
154:
150:
146:
142:
138:
134:
126:
121:
114:
109:
104:
93:
91:
87:
81:
76:
73:
72:
68:
65:
58:
54:
49:
45:
41:
36:
31:
19:
5467:CCN proteins
5404:
5400:
5390:
5363:
5359:
5349:
5322:
5318:
5308:
5275:
5271:
5264:
5231:
5227:
5221:
5189:(1): 63–69.
5186:
5182:
5172:
5145:
5141:
5131:
5096:
5092:
5082:
5047:
5043:
5033:
5009:(1): 59–67.
5006:
5002:
4992:
4965:
4961:
4951:
4934:
4930:
4924:
4907:
4903:
4897:
4864:
4860:
4824:
4820:
4810:
4783:
4779:
4729:
4725:
4715:
4680:
4676:
4666:
4631:
4627:
4585:
4581:
4571:
4546:
4542:
4536:
4499:
4495:
4485:
4448:
4444:
4434:
4397:
4393:
4383:
4356:
4352:
4342:
4315:
4311:
4301:
4268:
4264:
4257:
4232:
4228:
4221:
4168:
4164:
4154:
4119:
4115:
4101:
4066:
4062:
4014:
4010:
4000:
3968:(1): 69–82.
3965:
3959:
3949:
3924:
3920:
3913:
3876:
3872:
3862:
3837:
3833:
3823:
3796:
3792:
3782:
3755:
3751:
3741:
3706:
3702:
3692:
3657:
3653:
3643:
3602:
3598:
3592:
3565:
3561:
3551:
3516:
3512:
3502:
3467:
3463:
3453:
3426:
3422:
3412:
3395:
3391:
3387:
3381:
3344:
3340:
3330:
3303:
3299:
3289:
3254:
3250:
3240:
3213:
3209:
3199:
3174:
3170:
3116:
3112:
3064:
3060:
3050:
3023:
3019:
3009:
2974:
2970:
2926:
2922:
2912:
2877:
2873:
2821:
2818:J. Cell Biol
2817:
2769:
2765:
2755:
2720:
2716:
2674:
2670:
2630:
2626:
2616:
2589:
2585:
2543:
2539:
2529:
2502:
2498:
2488:
2453:
2449:
2439:
2414:
2410:
2404:
2369:
2365:
2355:
2328:
2324:
2314:
2289:
2285:
2279:
2244:
2240:
2230:
2195:
2191:
2143:
2139:
2129:
2102:
2098:
2088:
2053:
2049:
2039:
2004:
2000:
1950:
1946:
1906:
1902:
1892:
1883:
1874:
1865:
1856:
1789:
1749:
1720:
1711:
1683:
1680:Inflammation
1638:
1630:
1617:gastrulation
1610:
1602:
1600:
1589:, stimulate
1572:
1557:and enables
1528:
1511:glycosylated
1491:
1350:
1341:wound repair
1335:, which are
1327:(CCN5), and
1306:
1277:inflammation
1250:
1242:
1234:
1230:
1226:
1222:
1221:
1144:
1123:
1097:
1076:
1052:
1033:
1007:
988:
962:
943:
923:
918:
408:
401:
367:145,355,736
354:145,352,731
128:External IDs
83:
4726:Mol. Cancer
4468:2433/124230
4417:10371/29557
4312:Circulation
3752:Circulation
3562:Development
2241:Mol. Pathol
2099:J. Cell Sci
1775:cells, and
1547:macrophages
1535:endothelial
1309:fibroblasts
1297:retinopathy
1293:nephropathy
442:gallbladder
266:85,584,589
253:85,580,761
106:Identifiers
5446:Categories
5093:Cancer Res
4931:Cancer Res
4904:Cancer Res
4582:Cancer Res
2717:J. Immunol
1851:, May 2017
1830:, May 2017
1807:References
1761:xenografts
1757:metastasis
1731:restenosis
1561:to induce
1551:angiogenic
1494:N-terminal
1461:vitamin D3
1399:including
1265:senescence
759:chemotaxis
532:right lung
524:belly cord
412:(ortholog)
149:HomoloGene
4861:Head Neck
4677:J. Pathol
4394:Circ. Res
4293:205431163
4195:0027-8424
3635:205213660
3513:Circ. Res
3210:Dev. Biol
1727:neointima
1708:Arthritis
1563:apoptosis
1543:monocytes
1469:tamoxifen
1291:-related
1261:apoptosis
1147:NP_034646
1126:NP_001545
1100:NM_010516
1079:NM_001554
909:Orthologs
446:vena cava
157:GeneCards
5433:19632997
5382:15471875
5341:11598125
5300:21302082
5292:15389821
5272:Prostate
5248:12671667
5213:19898959
5164:16115920
5123:20233866
5074:20172544
5025:18575751
4984:15613452
4943:11751417
4916:11059746
4889:42617874
4881:20848406
4843:16243794
4802:11297518
4758:21232118
4707:19402132
4658:18941464
4604:18794119
4563:16409133
4549:: 1–18.
4528:21212276
4477:18388330
4426:17234971
4375:16774841
4334:12105167
4285:25709087
4249:20191585
4213:27482114
4146:18599605
4108:Moyer MP
4093:19584265
4041:19364818
3992:29260442
3941:17699553
3905:17626014
3854:12398938
3815:10841170
3774:15117851
3733:20930261
3684:18161745
3627:18480812
3584:12702657
3543:17023674
3494:12446788
3445:11356704
3373:20675382
3322:17823253
3281:16581771
3191:12215267
3091:24280864
3067:: 2842.
3042:11120741
3001:20526329
2945:12364323
2904:17318182
2848:16275757
2796:16239428
2747:20164416
2693:12036876
2649:10446209
2608:11897702
2562:10821835
2431:20452491
2325:Oncogene
2306:12231357
2271:12665631
2222:18775791
2170:18789696
2121:17130294
2031:22129992
1977:21805345
1903:Oncogene
1847:–
1826:–
1801:melanoma
1639:In skin
1579:paxillin
1506:cysteine
1465:estrogen
1393:TATA box
1389:promoter
1323:(CCN4),
1289:diabetes
1273:placenta
1269:integrin
1237:), is a
1195:Wikidata
888:Sources:
504:calvaria
5424:2758018
5256:7107243
5204:2821476
5114:2848876
5065:3349619
5044:J. Urol
4749:3027193
4698:7316387
4649:2584944
4519:3059032
4204:4995973
4173:Bibcode
4137:2475777
4084:2712585
4032:2698731
3983:5842195
3896:2831223
3724:2984611
3675:2693329
3607:Bibcode
3534:1626492
3404:1419914
3364:2951207
3272:1446962
3232:9441684
3153:9600969
3121:Bibcode
3069:Bibcode
2992:2919364
2895:1817641
2839:1626352
2787:1367263
2738:2832719
2521:9446626
2480:2355916
2396:2062642
2347:9135077
2262:1187305
2213:2668982
2161:2683937
2080:3841511
2022:3663145
1968:3651699
1925:9135077
1849:Ensembl
1828:Ensembl
1803:cells.
1771:cells,
1767:cells,
1477:hypoxia
1385:mir-155
1361:introns
1021:UniProt
976:Ensembl
915:Species
894:QuickGO
520:decidua
387:pattern
113:Aliases
5431:
5421:
5380:
5339:
5298:
5290:
5254:
5246:
5211:
5201:
5162:
5121:
5111:
5072:
5062:
5023:
4982:
4941:
4914:
4887:
4879:
4841:
4800:
4756:
4746:
4705:
4695:
4656:
4646:
4602:
4561:
4526:
4516:
4475:
4424:
4373:
4332:
4291:
4283:
4247:
4211:
4201:
4193:
4144:
4134:
4091:
4081:
4039:
4029:
3990:
3980:
3939:
3903:
3893:
3852:
3813:
3772:
3731:
3721:
3682:
3672:
3633:
3625:
3599:Nature
3582:
3541:
3531:
3492:
3485:139880
3482:
3443:
3402:
3371:
3361:
3320:
3279:
3269:
3230:
3189:
3151:
3141:
3089:
3040:
2999:
2989:
2943:
2902:
2892:
2874:EMBO J
2846:
2836:
2794:
2784:
2745:
2735:
2691:
2647:
2606:
2560:
2519:
2478:
2471:360792
2468:
2429:
2394:
2387:328320
2384:
2345:
2304:
2269:
2259:
2220:
2210:
2168:
2158:
2119:
2078:
2071:554634
2068:
2050:EMBO J
2029:
2019:
1975:
1965:
1923:
1781:glioma
1755:, and
1746:Cancer
1733:after
1692:, and
1668:, and
1445:TGF-β1
1427:, and
1373:3’-UTR
1365:5’-UTR
1263:, and
1181:search
1179:PubMed
1054:P18406
1035:O00622
931:Entrez
558:BioGPS
508:dermis
470:nipple
245:1p22.3
137:602369
5296:S2CID
5252:S2CID
4885:S2CID
4732:: 8.
4289:S2CID
3703:Aging
3631:S2CID
3388:cyr61
3144:27701
2766:Blood
2671:Blood
1694:TRAIL
1603:Cyr61
1498:IGFBP
1433:Z-DNA
1413:HNF3b
1391:is a
1357:exons
1329:WISP3
1325:WISP2
1321:WISP1
1243:CYR61
1229:) or
1227:CYR61
964:16007
924:Mouse
919:Human
890:Amigo
410:Mouse
403:Human
350:Start
285:Mouse
249:Start
182:Human
145:88613
5429:PMID
5378:PMID
5337:PMID
5288:PMID
5244:PMID
5209:PMID
5160:PMID
5119:PMID
5070:PMID
5021:PMID
4980:PMID
4939:PMID
4912:PMID
4877:PMID
4839:PMID
4798:PMID
4754:PMID
4703:PMID
4654:PMID
4600:PMID
4559:PMID
4524:PMID
4473:PMID
4422:PMID
4371:PMID
4330:PMID
4281:PMID
4245:PMID
4209:PMID
4191:ISSN
4142:PMID
4089:PMID
4037:PMID
3988:PMID
3937:PMID
3901:PMID
3850:PMID
3834:Bone
3811:PMID
3770:PMID
3729:PMID
3680:PMID
3623:PMID
3580:PMID
3539:PMID
3490:PMID
3441:PMID
3400:PMID
3369:PMID
3318:PMID
3277:PMID
3228:PMID
3187:PMID
3149:PMID
3087:PMID
3038:PMID
2997:PMID
2941:PMID
2900:PMID
2844:PMID
2792:PMID
2743:PMID
2689:PMID
2645:PMID
2604:PMID
2558:PMID
2517:PMID
2476:PMID
2427:PMID
2392:PMID
2343:PMID
2302:PMID
2267:PMID
2218:PMID
2166:PMID
2117:PMID
2076:PMID
2027:PMID
1973:PMID
1921:PMID
1700:and
1690:FasL
1686:TNFα
1583:MAPK
1559:TNFα
1545:and
1467:and
1457:cAMP
1439:and
1421:NFκB
1381:mRNA
1313:CTGF
1295:and
1246:gene
1235:CCN1
945:3491
393:Bgee
341:Band
302:Chr.
240:Band
199:Chr.
161:CCN1
153:1194
133:OMIM
120:CCN1
90:4D11
86:4D0Z
67:RCSB
64:PDBe
33:CCN1
5419:PMC
5409:doi
5405:284
5368:doi
5364:279
5327:doi
5323:276
5280:doi
5236:doi
5199:PMC
5191:doi
5150:doi
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