242:
219:
1318:. This regulation may be done through Excitatory Amino Acid Transporters (EAATs), which decrease extracellular glutamate and increase intracellular glutamate in astrocytes. When looking at its structure, xCT seems to be the main determinant for the system's activity. Glutamate and cystine can be transported in both directions, but, generally, more cystine is imported and more glutamate is exported. Extracellular glutamate acts as a competitive inhibitor for cystine uptake via system Xc-.
116:
141:
1515:
glutathione levels after the decrease in cystine transport. On the other hand, a decrease in system Xc- activity may lead to an increase in the activation of synaptic NMDA receptors due to the decrease in activation of Group 2 mGluRs. A decrease in nonvesicular release of glutamate leads to an increase in expression of postsynaptic glutamate receptors, such as NMDA receptors. A disruption in nonvesicular glutamate release may affect synapse formation, lead to altered release of
493:
1232:
507:
500:
248:
147:
1647:) is an environmental neurotoxin that can act on system Xc- and inhibit cystine uptake. This leads to a decrease in glutathione levels and an increase in oxidative stress. BMAA can also be transported by system Xc- and lead to an increase in glutamate release and an increase in excitotoxicity. Therefore, BMAA prevents the positive effects of cystine uptake and creates the negative effects of increasing glutamate release.
1327:
1377:
1240:
1253:
1200:, the SLC7A11 light chain comprises system Xc-, which is the functional cystine-glutamate antiporter. While the SLC3A2 heavy chain is a chaperone for many other light chains that participate in amino acid transport, the SLC7A11 light chain is specific for system Xc-, and the terms xCT/SLC7A11 and system Xc- are used interchangeably in much of the literature.
1342:, and the fact that it is released at high speeds. This mechanism of release at the synaptic cleft is partially controlled through the active transport of glutamate out of astrocytes by system Xc-. This release also has a physiological role in the regulation of glutamatergic metabotropic receptors and control of other neurotransmitters.
1587:
1514:
activation, suggesting that glutamate released from system Xc- may cause the activation of extrasynaptic NMDA receptors. A decrease in system Xc- activity may cause a decrease in the activation of extrasynaptic NMDA receptors due to either a decrease in extrasynaptic
Glutamate levels or a decrease in
1477:
Repeated administration of cocaine causes disruptions in glutamate homeostasis that lead to a decrease in function of EAATs. It is also possible that glutamate is diffusing from surrounding synapses and is stimulating extrasynaptic receptors. All of these factors may be leading to the disruptions in
1626:
may be due to mitochondrial dysfunction or oxidative stress, both of which could be caused by a decrease in glutathione levels. Administration of N-acetylcysteine has been shown to counter age-related damage to mitochondria. The therapeutic effects of N-acetylcysteine in the treatment of
Parkinson's
1522:
An increase in the expression of Group 2 mGluRs, which could arise from a chronic under stimulation of these receptors, has been associated with schizophrenia. An increase in levels of system Xc- has also been found in postmortem schizophrenia patients, indicating that there may have been a decrease
1469:
and an inhibition of synaptic release of glutamate. Cysteine prodrugs also lead to an increase in antioxidant properties by increasing levels of glutathione. Increased levels of glutathione lead to a lower toxicity of methamphetamine and alcohol, and cause a decrease in tumor formation after chronic
1668:
system Xc- function also plays a role in non-neural cancers. Within the gastrointestinal tract, SLC7A11 is upregulated in esophageal, liver, gastric, colorectal, and pancreatic cancers, and inhibition of SLC7A11 has been shown to inhibit tumor progression, likely through induction of ferroptosis.
1456:
of withdrawn rats leads to an increase in extrasynaptic glutamate, near the levels of the control rats, and prevents an increase in synaptic glutamate signaling after a cocaine injection. These findings suggest there is a decrease in system Xc- activity in cocaine-withdrawn rats. It has also been
2734:
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P,
1464:
or L-2-oxothiazolidine-4-carboxylate blocks cocaine reinstatement in rats. N-acetylcysteine has been shown to decrease drug-seeking behavior for nicotine and heroin as well. However, N-acetylcysteine does not alter the cocaine-induced rush or euphoria; it only causes a reduction in drug-seeking
1273:
imports cystine and exports glutamate, which are both amino acids. An antiporter functions with a one-to-one counter-transport, which is when one substance is transported across the membrane at the same time another substance is transported across the membrane in the opposite direction. The
1345:
It has been demonstrated that, in the embryonic retina, Xc- exchanger is responsible for 50% of total glutamate uptake, representing a Sodium-Independent system within this tissue. The high activity of Xc- in the retina is correlated to a neuroprotective role, once it can take up excessive
1579:(ALS) is clearly linked to changes in glutamate signaling and glutathione levels; there is also an astrocytic component linked to the disease. All of these factors suggest that a dysfunction in system Xc- may contribute to ALS. It has been observed that an increase in the expression of
1369:. This amino acid is a rate limiting substrate used in the SLC7A11 cystine/glutamate transporter and is usually imported into the cell. Cysteine-158 is specifically used in the formation of the disulfide bridge for the protein structure of system Xc-. There are neurotoxins, such as
2239:
Lin CH, Lin PP, Lin CY, Lin CH, Huang CH, Huang YJ, Lane HY (January 2016). "Decreased mRNA expression for the two subunits of system xc(-), SLC3A2 and SLC7A11, in WBC in patients with schizophrenia: Evidence in support of the hypo-glutamatergic hypothesis of schizophrenia".
1523:
in net function of these receptors as well, leading to greater expression. It has been observed that
Schizophrenia patients have a decreased level of glutathione in their prefrontal cortex, further supporting the conclusion that system Xc- may not be functioning properly.
1566:
has been shown to lead to an increase in system Xc- expression, therefore there must be a balance between the positive protective effects of increased glutathione levels and the negative excitotoxicity effects of increased extrasynaptic glutamate levels.
1669:
Outside of the gastrointestinal tract, SLC7A11 expression is increased in prostate cancer, bladder cancer, non-small cell lung carcinoma, and melanoma. Inhibition of SLC7A11 in many of these cancers also shows promise in reducing tumor progression.
1529:
Recent study showed that mRNA expression levels of both SLC3A2 and SLC7A11 in WBCs of schizophrenia patients are lower than that of healthy individuals. The finding supports the hypo-glutamatergic neurotransmission hypothesis in schizophrenia.
2538:
Bassi MT, Gasol E, Manzoni M, Pineda M, Riboni M, MartĂn R, Zorzano A, Borsani G, PalacĂn M (May 2001). "Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc-".
1465:
behavior. N-acetylcysteine works by increasing levels of cysteine in cells, leading to an increase in system Xc- activity. This increase in system Xc- activity leads to an increase in extrasynaptic glutamate, causing stimulation of Group 2
1659:
is essentially a glial-derived tumor. These can be induced by an increase in glutamate levels due to an increase in system Xc- activity. Using inhibitors of system Xc- as a treatment for gliomas is currently under active investigation.
1207:
production throughout nervous and non-nervous tissues. In the nervous system, SLC7A11 regulates synaptic activity by stimulating extrasynaptic receptors and performs nonvesicular glutamate release. This gene is highly expressed by
2735:
Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".
2613:"Thiol modification of cysteine 327 in the eighth transmembrane domain of the light subunit xCT of the heteromeric cystine/glutamate antiporter suggests close proximity to the substrate binding site/permeation pathway"
8074:
2423:
Bridges CC, Kekuda R, Wang H, Prasad PD, Mehta P, Huang W, Smith SB, Ganapathy V (January 2001). "Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells".
6023:
1421:(CNS) disorders are due to a dysfunction in glutamate signaling. Glutamate is transported via EAATs and system Xc-. If either of these transporters are impaired, it could result in a disruption in glutamate
1256:
There are three different types of transporters including: uniporter, synporter, and anti porter. The anti-porter allows for two different substances to move in opposite directions at a one-to-one counter
6043:
1615:
4, both of which increase system Xc- expression. It has also been shown that administration of N-acetylcysteine leads to a significant improvement in certain cognitive tasks for
Alzheimer's patients.
1290:, and the SLC3A2 heavy chain appears to be highly conserved among transporters. The human SLC7A11 has an 89% similarity of amino acids to the homologous mouse xCT protein. The complementary DNA,
1212:
and couples the uptake of one molecule of cystine with the release of one molecule of glutamate. The expression of Xc- was detected throughout the brain with higher expression found in the
1526:
Clinical trials have shown therapeutic potential for N-acetylcysteine in treating schizophrenia. Again, changes in EAATs due to disruptions in
Glutamate homeostasis may also be involved.
8067:
9086:
8040:
6016:
1294:, has a total of 9648 base pairs. The SLC7A11 gene has been found not only in the brain, but has also been found to be expressed in the spinal cord, pancreas, and in glioma cells.
8060:
8033:
2192:"Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling"
1805:
Wang H, Tamba M, Kimata M, Sakamoto K, Bannai S, Sato H (June 2003). "Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT".
1452:, most likely due to the decrease in extrasynaptic glutamate levels, leads to an increase in cocaine-evoked glutamate signaling in their NAcc. An infusion of cysteine in the
255:
154:
9082:
6009:
1338:
in mammalian cells. Glutamate is necessary for excitatory signaling between neurons. The release must be highly organized, due to the large amounts of glutamate at the
2445:
Sato H, Tamba M, Kuriyama-Matsumura K, Okuno S, Bannai S (2001). "Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc-".
2903:
1302:
There are many mechanisms that exist to regulate the expression of system Xc-, although it is not the sole determinant of extracellular glutamate or intracellular
5924:
1902:
Lewerenz J, Hewett SJ, Huang Y, Lambros M, Gout PW, Kalivas PW, Massie A, Smolders I, Methner A, Pergande M, Smith SB, Ganapathy V, Maher P (February 2013).
4283:
1506:
and cortex. A decrease in system Xc- activity may result in an increase in synaptic glutamate and a decrease in extrasynaptic glutamate. Administration of
8640:
8499:
2871:
1470:
smoking. N-acetylcysteine has been shown to decrease cravings and use of cocaine and tobacco, as well as other compulsive behaviors such as gambling and
8256:
905:
886:
77:
7092:
5324:
2275:
Hardingham GE, Fukunaga Y, Bading H (May 2002). "Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways".
1440:
produces a decrease in
Cystine-Glutamate exchange via system Xc-, leading to a decrease in basal, extra synaptic glutamate levels in the nucleus
2693:"Induction of cystine-glutamate transporter xc- by human immunodeficiency virus type 1 transactivator protein tat in retinal pigment epithelium"
4189:
2110:"Pharmacological characterization of glutamate Na+-independent transport in retinal cell cultures: implications in the glutathione metabolism"
1558:
death in culture and in the rat optic nerve. However, an increase in system Xc- activity also has a protective effect by increasing levels of
7124:
5719:
5245:
1746:
1728:
6713:
9112:
5577:
3445:
3114:
2881:
1373:, that can prevent the intake of cystine, which can lead to decreased extracellular glutamate levels and an increase in oxidative stress.
7032:
4587:
4081:
3007:
3002:
2927:
2896:
1105:
241:
8769:
8370:
7961:
6788:
1904:"The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities"
1314:. The inhibition of uptake of extracellular cystine into cells leads to decreased levels of intracellular glutathione which leads to
8985:
8886:
8814:
8710:
8561:
8403:
8217:
8103:
5973:
5874:
5041:
4003:
3301:
3215:
2972:
2008:
Dixon SJ, Patel DN, Welsch M, Skouta R, Lee ED, Hayano M, Thomas AG, Gleason CE, Tatonetti NP, Slusher BS, Stockwell BR (May 2014).
1112:
1444:
core (NAcc) region of the brains of cocaine-withdrawn rats. It has also been observed in withdrawn rats that a decrease in Group 2
218:
1840:
3805:
8701:
8394:
8094:
8083:
4066:
3142:
2987:
1854:
Lewerenz J, Maher P, Methner A (January 2012). "Regulation of xCT expression and system x (c) (-) function in neuronal cells".
1715:
1694:
1449:
6588:
6294:
5914:
3541:
2780:
Kaleeba JA, Berger EA (March 2006). "Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT".
2691:
Bridges CC, Hu H, Miyauchi S, Siddaramappa UN, Ganapathy ME, Ignatowicz L, Maddox DM, Smith SB, Ganapathy V (September 2004).
9117:
6946:
5894:
5889:
5860:
4401:
3965:
3767:
3762:
2889:
1711:
1441:
9044:
8948:
8861:
8789:
140:
115:
6694:
6032:
3960:
3955:
3950:
3935:
3930:
3925:
3920:
3710:
2576:
Sasaki H, Sato H, Kuriyama-Matsumura K, Sato K, Maebara K, Wang H, Tamba M, Itoh K, Yamamoto M, Bannai S (November 2002).
1576:
5286:
5088:
4888:
1690:
1224:. The inhibition of system Xc- has been found to alter a number of behaviors, which suggests that it plays a key role in
9078:
8026:
5884:
1608:
1190:
57:
6842:
3876:
1519:, and could even disturb cortical migration during development. All of these seem to be associated with schizophrenia.
254:
153:
7321:
4856:
2474:
Shih AY, Murphy TH (April 2001). "xCt cystine transporter expression in HEK293 cells: pharmacology and localization".
1766:"Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins"
1547:
4735:
4439:
247:
146:
8251:
7114:
4808:
3311:
2920:
5465:
5121:
3614:
5869:
3757:
2658:"Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility"
5653:
2578:"Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression"
2320:"Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations"
1494:
may be due to an increase or a decrease in glutamate signaling, leading to abnormal excitatory signaling in the
6813:
6747:
6077:
5919:
3741:
3508:
2010:"Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis"
950:
65:
5610:
6959:
4137:
8625:
8477:
7976:
5879:
5511:
3240:
1457:
found that cocaine increases glutamate signaling in the synaptic cleft, further supporting this conclusion.
931:
8261:
8127:
7851:
7326:
7119:
6931:
6922:
2503:
Kim JY, Kanai Y, Chairoungdua A, Cha SH, Matsuo H, Kim DK, Inatomi J, Sawa H, Ida Y, Endou H (June 2001).
1623:
1600:
1418:
7846:
6774:
6471:
5855:
5691:
5377:
4562:
4487:
3881:
3752:
3747:
3321:
2923:
2505:"Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells"
1586:
1958:"System xc cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS"
1841:"Entrez Gene: SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11"
6969:
6684:
6425:
5952:
5947:
3914:
3316:
2789:
2744:
1612:
1283:
1213:
129:
44:
7356:
6481:
1310:
is extracellular glutamate; when it becomes excessive, it goes from an excitatory transmitter to an
7898:
7331:
6737:
6164:
6062:
5544:
3250:
3025:
8630:
8482:
6798:
1278:
amino acid transporter, requiring both the SLC7A11 light chain and SLC3A2 heavy chain linked by a
9049:
9039:
8953:
8938:
8866:
8856:
8794:
8784:
8757:
8422:
8177:
8086:
7941:
7274:
7269:
7192:
7109:
6964:
6953:
6783:
6035:
5992:
5989:
3306:
2856:
2813:
2768:
2564:
2300:
2139:
1879:
1583:, a transcription factor for system Xc-, leads to a protective effect in mice with ALS symptoms.
1307:
1225:
89:
8752:
8467:
8197:
8192:
7710:
7695:
7227:
7097:
7057:
6400:
1389:
System Xc- can be inhibited by many small molecules. Excess amounts of the endogenous substrate
1088:
1067:
1041:
1020:
492:
8157:
7946:
7926:
7921:
7878:
7705:
7675:
7366:
7264:
7237:
7187:
7154:
7134:
7129:
7072:
7067:
7052:
7042:
7022:
7017:
6608:
6568:
6516:
6254:
6189:
6179:
6174:
1627:
disease has not been examined yet, though there is a clinical trial that is currently ongoing.
1306:. An example is amino acid deprivation, which triggers up regulation of the transporter. A key
9059:
8963:
8876:
8804:
8620:
8472:
8323:
8207:
7856:
7222:
7207:
6979:
6974:
6862:
6762:
6658:
6476:
6369:
5447:
5442:
4790:
4785:
4712:
4707:
4702:
4697:
4692:
4687:
4667:
4662:
4657:
4652:
4637:
4627:
4617:
4612:
4602:
4577:
4383:
4368:
4363:
3985:
3980:
3975:
2848:
2805:
2760:
2722:
2679:
2644:
2599:
2556:
2526:
2491:
2462:
2433:
2400:
2349:
2292:
2257:
2221:
2131:
2090:
2041:
1987:
1933:
1871:
1822:
1787:
1495:
1231:
1221:
506:
499:
37:
8281:
8052:
7742:
7737:
7732:
7727:
7259:
6679:
6154:
5701:
5668:
5635:
5625:
5592:
5587:
5521:
5402:
5354:
5344:
5301:
5265:
5260:
5227:
5222:
5217:
5212:
5203:
5198:
5193:
5165:
5155:
5146:
5141:
5136:
4971:
4956:
4951:
4936:
4903:
4870:
4780:
4740:
4497:
4469:
4454:
4449:
4444:
4421:
4416:
4264:
4260:
4251:
4209:
4033:
4023:
4013:
3945:
3891:
3825:
3810:
3644:
3639:
3634:
3485:
3386:
3381:
3351:
3275:
3270:
3265:
3192:
85:
7411:
6728:
6674:
6452:
6390:
6067:
5747:
3848:
3586:
3576:
3561:
3523:
3518:
3336:
3260:
3187:
2912:
2838:
2797:
2752:
2712:
2704:
2669:
2634:
2624:
2589:
2548:
2516:
2483:
2454:
2390:
2380:
2339:
2331:
2284:
2249:
2211:
2203:
2121:
2080:
2072:
2031:
2021:
1977:
1969:
1923:
1915:
1863:
1814:
1777:
1563:
1516:
1507:
1471:
1461:
334:
265:
209:
164:
8162:
6349:
6001:
9054:
9034:
8958:
8933:
8871:
8851:
8799:
8779:
8670:
8529:
8318:
8276:
8202:
8142:
7911:
7861:
7621:
7541:
7506:
7406:
7242:
7077:
6847:
6757:
6526:
6491:
6324:
6259:
6102:
5831:
2916:
1604:
1555:
1499:
309:
2793:
2748:
7821:
7801:
7566:
7501:
7421:
7401:
7197:
6669:
6598:
6385:
6304:
2717:
2692:
2395:
2369:"The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer"
2368:
2344:
2319:
2216:
2191:
2085:
2060:
2036:
2009:
1982:
1957:
1928:
1903:
1543:
1479:
1366:
1339:
1311:
2521:
2504:
1818:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
645:
640:
624:
619:
614:
609:
604:
599:
594:
589:
584:
579:
563:
558:
553:
548:
9106:
8600:
8447:
8271:
8187:
8137:
7991:
7986:
7966:
7826:
7791:
7646:
7641:
7631:
7606:
7601:
7536:
7496:
7456:
7037:
6742:
6654:
6593:
6538:
6506:
6365:
6299:
6119:
6092:
6044:
5847:
2875:
2253:
1973:
1539:
1511:
1491:
1426:
1398:
1275:
1196:
that is chloride dependent, also known as xCT. Along with a heavy chain subunit from
535:
2825:
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006).
2817:
2568:
2143:
1883:
1326:
69:
8489:
8355:
8350:
7781:
7611:
7581:
7486:
7451:
7386:
7371:
7149:
6650:
6623:
6578:
6375:
6361:
6329:
6279:
6234:
2860:
2827:"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks"
2772:
2611:
JimĂ©nez-Vidal M, Gasol E, Zorzano A, Nunes V, PalacĂn M, ChillarĂłn J (March 2004).
327:
106:
2304:
2126:
2109:
1603:
patients. It has been found in
Alzheimer's patients that there is an increase in
93:
8682:
8546:
8380:
8328:
8313:
7971:
7956:
7936:
7906:
7836:
7720:
7700:
7690:
7685:
7665:
7626:
7576:
7571:
7556:
7546:
7511:
7461:
7431:
7426:
7416:
7336:
7279:
7232:
7164:
7139:
7087:
7002:
6888:
6826:
6803:
6511:
6496:
6442:
6430:
6244:
6219:
6107:
6082:
5983:
5470:
4926:
4522:
3723:
1751:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1733:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1559:
1550:
and can cause neuronal death. It has been observed that glutamate released from
1503:
1422:
1406:
1347:
1315:
1303:
1204:
2843:
2826:
1376:
410:
9024:
8764:
8665:
8660:
8615:
8610:
8605:
8524:
8519:
8462:
8457:
8452:
8308:
8288:
8009:
7981:
7931:
7916:
7893:
7888:
7883:
7816:
7786:
7776:
7715:
7651:
7636:
7616:
7561:
7531:
7516:
7491:
7476:
7441:
7436:
7396:
7391:
7361:
7346:
7306:
7284:
7247:
7217:
7202:
7182:
6940:
6910:
6893:
6883:
6638:
6628:
6603:
6558:
6435:
6420:
6415:
6395:
6354:
6344:
6334:
6314:
6309:
6269:
6264:
6224:
6214:
6199:
6139:
6114:
5906:
5064:
2076:
1867:
1636:
1599:
There is indirect evidence to suggest that system Xc- might be upregulated in
1287:
1270:
1193:
1168:
226:
123:
73:
2458:
2385:
2108:
Oliveira KR, Herculano AM, Crespo-LĂłpez ME, do
Nascimento JL (January 2010).
1782:
1765:
1498:
region of the brain. Glutamate release by astrocytes has been linked to the
9009:
8923:
8910:
8833:
8742:
8729:
8687:
8595:
8590:
8551:
8442:
8437:
8266:
8241:
8152:
8147:
8132:
7806:
7796:
7754:
7680:
7670:
7596:
7591:
7551:
7526:
7521:
7471:
7446:
7376:
7351:
7341:
7316:
7311:
7301:
7177:
7062:
7047:
7027:
7012:
7007:
6898:
6723:
6718:
6664:
6553:
6548:
6543:
6501:
6410:
6405:
6380:
6289:
6229:
6209:
6204:
6194:
6184:
6159:
6087:
5843:
2801:
1551:
1402:
1390:
1335:
1279:
1269:
amino acid transport system highly specific for cystine and glutamate. This
1209:
850:
470:
348:
293:
280:
192:
179:
81:
2852:
2809:
2764:
2726:
2683:
2674:
2657:
2648:
2629:
2612:
2603:
2594:
2577:
2560:
2530:
2495:
2487:
2466:
2437:
2404:
2353:
2296:
2261:
2225:
2135:
2094:
2045:
1991:
1937:
1875:
1826:
1791:
1239:
2552:
2367:
Jyotsana, Nidhi; Ta, Kenny T.; DelGiorno, Kathleen E. (23 February 2022).
2207:
1919:
1152:
1147:
8975:
8675:
8534:
8338:
8333:
8167:
7951:
7749:
7656:
7481:
7466:
7381:
7296:
7212:
7102:
6984:
6915:
6905:
6767:
6633:
6531:
6339:
5437:
5432:
5427:
5359:
4976:
4717:
4682:
4677:
4672:
4647:
4642:
4632:
4622:
4607:
4597:
4592:
4582:
4572:
4567:
4557:
4547:
4542:
4537:
4378:
4373:
4358:
4353:
4348:
4343:
4338:
4333:
4103:
3970:
3297:
2708:
2656:
Gasol E, JimĂ©nez-Vidal M, ChillarĂłn J, Zorzano A, PalacĂn M (July 2004).
2335:
1362:
1136:
995:
976:
2756:
2026:
8365:
8360:
8345:
8182:
7995:
7841:
7831:
7811:
7766:
7252:
6867:
6852:
6818:
6752:
6643:
6521:
6239:
6169:
6149:
6097:
5804:
5799:
5794:
5789:
5784:
5779:
5729:
5724:
5696:
5673:
5663:
5658:
5630:
5620:
5615:
5582:
5526:
5516:
5422:
5417:
5412:
5407:
5397:
5392:
5387:
5382:
5349:
5339:
5334:
5329:
5306:
5296:
5291:
5268:
5255:
5250:
5184:
5179:
5170:
5160:
5131:
5126:
5103:
5098:
5093:
5070:
5046:
5023:
4966:
4961:
4946:
4941:
4931:
4908:
4898:
4893:
4865:
4860:
4838:
4833:
4828:
4823:
4818:
4813:
4775:
4770:
4765:
4760:
4755:
4750:
4745:
4532:
4527:
4517:
4512:
4507:
4502:
4492:
4464:
4459:
4411:
4406:
4328:
4323:
4318:
4313:
4308:
4303:
4298:
4293:
4288:
4246:
4237:
4228:
4223:
4214:
4204:
4199:
4194:
4148:
4143:
4119:
4114:
4109:
4048:
4043:
4038:
4028:
4018:
4008:
3940:
3896:
3886:
3858:
3853:
3830:
3820:
3815:
3787:
3782:
3777:
3772:
3720:
3715:
3671:
3666:
3661:
3656:
3649:
3629:
3624:
3619:
3596:
3591:
3490:
3480:
3475:
3401:
3396:
3391:
3376:
3371:
3366:
3361:
3356:
3197:
3095:
3090:
3085:
3080:
3075:
2639:
1437:
1394:
1393:
inhibits the function of system Xc-. Synthetic small molecules such as
1358:
1266:
1186:
962:
917:
8968:
8905:
8585:
8580:
8539:
8432:
8427:
7871:
7771:
7144:
6875:
6857:
6834:
6129:
6124:
6049:
Tooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
5928:
5017:
4552:
4099:
3581:
3571:
3566:
3556:
3551:
3546:
3513:
3470:
3465:
3460:
3455:
3437:
3432:
3427:
3422:
3346:
3341:
3331:
3326:
3293:
3255:
3245:
3235:
3230:
3220:
3182:
3177:
3172:
3167:
3162:
3157:
3152:
3147:
3124:
3119:
3070:
3060:
3055:
2997:
2992:
2982:
2977:
1656:
1466:
1445:
1217:
1120:
872:
1346:
extracellular glutamate and provide precursors for the synthesis of
1252:
9014:
8943:
8915:
8838:
8747:
8734:
8655:
8645:
8514:
8504:
8303:
8246:
7866:
7291:
7082:
6808:
6618:
6144:
6134:
4076:
4071:
3225:
3065:
3050:
3045:
3040:
3035:
3030:
2288:
1640:
1635:
There is evidence that system Xc- may serve as an entry point for
1585:
1375:
1325:
1251:
1238:
1230:
835:
831:
9004:
8650:
8509:
8375:
8298:
8236:
8122:
7759:
7586:
7172:
7159:
6793:
6613:
6583:
6573:
6486:
6319:
6284:
6274:
6072:
5559:
5554:
5549:
3450:
1644:
1580:
1453:
1370:
1291:
1175:
515:
61:
8056:
6005:
5987:
5829:
5768:
5493:
5325:
System A & N, sodium-coupled neutral amino-acid transporter
4999:
4171:
3692:
2954:
2939:
2885:
6997:
2003:
2001:
806:
negative regulation of oxidative stress-induced neuron death
2973:
high affinity glutamate and neutral amino-acid transporter
8986:
8887:
8815:
8711:
8562:
8404:
8218:
8104:
3419:
cationic amino-acid transporter/glycoprotein-associated
317:
3444:
glycoprotein-associated/light or catalytic subunits of
7289:
Uncompetitive pore blockers (mostly dizocilpine site):
6695:
2190:
Bridges R, Lutgen V, Lobner D, Baker DA (July 2012).
482:
5578:
Na-independent, system-L like amino-acid transporter
8984:
8885:
8813:
8709:
8700:
8560:
8402:
8393:
8216:
8102:
8093:
6693:
6451:
6042:
5905:
5842:
5740:
5712:
5684:
5646:
5603:
5570:
5537:
5504:
5458:
5370:
5317:
5279:
5238:
5114:
5081:
5057:
5034:
5010:
4919:
4881:
4849:
4801:
4728:
4480:
4432:
4394:
4276:
4182:
4130:
4092:
4059:
3996:
3907:
3869:
3841:
3798:
3734:
3703:
3607:
3534:
3501:
3412:
3286:
3208:
3135:
3106:
3018:
2965:
2476:
Biochemical and Biophysical Research Communications
1807:
Biochemical and Biophysical Research Communications
1081:
1060:
1034:
1013:
796:
regulation of cellular response to oxidative stress
445:
dentate gyrus of hippocampal formation granule cell
2509:Biochimica et Biophysica Acta (BBA) - Biomembranes
1707:
1705:
1703:
1686:
1684:
1682:
1764:Sato H, Tamba M, Ishii T, Bannai S (April 1999).
264:
163:
2697:Investigative Ophthalmology & Visual Science
2426:Investigative Ophthalmology & Visual Science
1956:Bridges RJ, Natale NR, Patel SA (January 2012).
816:regulation of AMPA glutamate receptor clustering
1951:
1949:
1947:
1897:
1895:
1893:
564:L-amino acid transmembrane transporter activity
48:, CCBR1, xCT, solute carrier family 7 member 11
6947:
6932:
1712:GRCm38: Ensembl release 89: ENSMUSG00000027737
811:regulation of glutathione biosynthetic process
8068:
6017:
2897:
1478:glutamate signaling that are associated with
8:
751:modulation of chemical synaptic transmission
4284:organic cation/anion/zwitterion transporter
2185:
2183:
2181:
2179:
2177:
2175:
2173:
1691:GRCh38: Ensembl release 89: ENSG00000151012
1405:can inhibit system Xc- function and induce
736:regulation of cell population proliferation
8706:
8399:
8099:
8075:
8061:
8053:
8034:Metabotropic glutamate receptor modulators
6024:
6010:
6002:
5984:
5839:
5826:
5765:
5501:
5490:
5007:
4996:
4179:
4168:
3806:human Na-sulfate/carboxylate cotransporter
3700:
3689:
2962:
2951:
2947:
2936:
2904:
2890:
2882:
2872:United States National Library of Medicine
2171:
2169:
2167:
2165:
2163:
2161:
2159:
2157:
2155:
2153:
846:
741:regulation of melanin biosynthetic process
721:regulation of neutrophil apoptotic process
531:
305:
204:
101:
9087:Glutamate metabolism/transport modulators
8994:Tooltip Metabotropic glutamate receptor 8
8895:Tooltip Metabotropic glutamate receptor 7
8823:Tooltip Metabotropic glutamate receptor 6
8719:Tooltip Metabotropic glutamate receptor 4
8570:Tooltip Metabotropic glutamate receptor 3
8412:Tooltip Metabotropic glutamate receptor 2
8226:Tooltip Metabotropic glutamate receptor 5
8112:Tooltip Metabotropic glutamate receptor 1
8041:Glutamate metabolism/transport modulators
2842:
2716:
2673:
2638:
2628:
2593:
2520:
2394:
2384:
2343:
2215:
2125:
2084:
2035:
2025:
1981:
1927:
1781:
1261:SLC7A11 is a member of a heterodimeric Na
821:regulation of glutamate metabolic process
786:L-glutamate import across plasma membrane
9083:Ionotropic glutamate receptor modulators
6453:
2870:This article incorporates text from the
1460:Administration of the cysteine prodrugs
801:regulation of cysteine metabolic process
595:intracellular membrane-bounded organelle
4402:Na+-dependent ascorbic acid transporter
1678:
1282:bridge. The SLC7A11 light chain has 12
791:dipeptide import across plasma membrane
7764:Alcohols/volatile anesthetics/related:
4190:Organic anion-transporting polypeptide
1510:leads to an increase in extrasynaptic
18:
6920:Other positive allosteric modulators:
6700:Tooltip N-Methyl-D-aspartate receptor
5246:proton-coupled amino-acid transporter
3446:heterodimeric amino-acid transporters
3115:heterodimeric amino-acid transporters
726:cellular response to oxidative stress
615:integral component of plasma membrane
549:cystine:glutamate antiporter activity
269:
230:
225:
168:
127:
122:
7:
3711:proton coupled metal ion transporter
2324:The Journal of Experimental Medicine
2065:Cellular and Molecular Life Sciences
453:endothelial cell of lymphatic vessel
8626:Pomaglumetad methionil (LY-2140023)
8478:Pomaglumetad methionil (LY-2140023)
7661:Ifenprodil (NR2B) site antagonists:
5287:sugar-phosphate/phosphate exchanger
4889:facilitative nucleoside transporter
2662:The Journal of Biological Chemistry
2617:The Journal of Biological Chemistry
2582:The Journal of Biological Chemistry
1770:The Journal of Biological Chemistry
1590:Alzheimer's disease-brain shrinkage
1203:SLC7A11 plays an important role in
731:glutathione transmembrane transport
701:response to organic cyclic compound
686:L-glutamate transmembrane transport
6225:Pesampator (BIIB-104, PF-04958242)
5089:type II Na-phosphate cotransporter
3302:sodium:neurotransmitter symporters
2447:Antioxidants & Redox Signaling
1908:Antioxidants & Redox Signaling
1185:gene encodes a sodium-independent
1078:
1057:
1031:
1010:
986:
967:
941:
922:
896:
877:
756:regulation of synapse organization
559:transmembrane transporter activity
487:
405:
343:
322:
14:
5042:Vesicular glutamate transporter 1
4004:Vesicular glutamate transporter 1
3877:proton oligopeptide cotransporter
1365:molecules and the formation of a
1171:that in humans is encoded by the
2254:10.1016/j.jpsychires.2015.10.007
1974:10.1111/j.1476-5381.2011.01480.x
505:
498:
491:
441:lumbar subsegment of spinal cord
253:
246:
240:
217:
152:
145:
139:
114:
9022:Positive allosteric modulators:
8973:Negative allosteric modulators:
8762:Positive allosteric modulators:
8680:Negative allosteric modulators:
8544:Negative allosteric modulators:
8487:Positive allosteric modulators:
8343:Negative allosteric modulators:
8286:Positive allosteric modulators:
8084:Metabotropic glutamate receptor
7701:Rislenemdaz (CERC-301, MK-0657)
6648:Negative allosteric modulators:
6536:Positive allosteric modulators:
6359:Negative allosteric modulators:
6112:Positive allosteric modulators:
4857:Na-coupled nucleoside transport
4736:multifunctional anion exchanger
4067:vesicular monoamine transporter
2242:Journal of Psychiatric Research
1962:British Journal of Pharmacology
1380:3-dimensional cystine structure
761:regulation of protein transport
656:lens fiber cell differentiation
6937:Tooltip Dehydroepiandrosterone
6245:Tulrampator (S-47445, CX-1632)
6140:Farampator (CX-691, ORG-24448)
2059:Cao JY, Dixon SJ (June 2016).
1609:eukaryotic initiation factor 2
706:ventricular system development
580:integral component of membrane
516:More reference expression data
471:More reference expression data
1:
9079:Receptor/signaling modulators
8027:Receptor/signaling modulators
7876:Unknown/unsorted antagonists:
6440:Unknown/unsorted antagonists:
6033:Ionotropic glutamate receptor
5720:multidrug and toxin extrusion
4809:fatty acid transport proteins
3026:facilitative GLUT transporter
2522:10.1016/S0005-2736(01)00338-8
1819:10.1016/S0006-291X(03)00808-8
1577:amyotrophic lateral sclerosis
1571:Amyotrophic lateral sclerosis
1361:is a dimer consisting of two
1235:Expression pattern of SLC7A11
1165:Cystine/glutamate transporter
691:glutathione metabolic process
238:
137:
5466:basolateral iron transporter
5122:nucleoside-sugar transporter
3615:sodium bile salt cotransport
3216:sodium glucose cotransporter
2127:10.1016/j.neuint.2009.09.002
2114:Neurochemistry International
1548:extrasynaptic NMDA receptors
646:response to oxidative stress
9113:Genes on human chromosome 4
7725:NR2A-selective antagonists:
7257:Polyamine site antagonists:
6482:Acromelic acid (acromelate)
6068:Acromelic acid (acromelate)
2921:membrane transport proteins
2061:"Mechanisms of ferroptosis"
1534:Neurodegenerative disorders
776:organic substance transport
671:response to toxic substance
585:rough endoplasmic reticulum
395:superior vestibular nucleus
363:stromal cell of endometrium
9134:
6165:Hydrochlorothiazide (HCTZ)
5654:Putative sugar transporter
2844:10.1016/j.cell.2006.09.026
1542:by system Xc- may lead to
1490:It has been proposed that
1385:Pharmacological Inhibition
1334:There is a high amount of
9072:
8611:LY-404,039 (pomaglumetad)
8458:LY-404,039 (pomaglumetad)
8018:
7107:Glycine site antagonists:
5999:
5969:
5838:
5825:
5775:
5764:
5500:
5489:
5006:
4995:
4178:
4167:
3699:
3688:
2961:
2950:
2946:
2935:
2077:10.1007/s00018-016-2194-1
1868:10.1007/s00726-011-0862-x
1747:"Mouse PubMed Reference:"
1729:"Human PubMed Reference:"
1425:and lead to a variety of
1151:
1146:
1142:
1135:
1119:
1106:Chr 4: 138.16 – 138.24 Mb
1100:
1085:
1064:
1053:
1038:
1017:
1006:
993:
989:
974:
970:
961:
948:
944:
929:
925:
916:
903:
899:
884:
880:
871:
856:
849:
845:
829:
746:lung alveolus development
534:
530:
513:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
8490:JNJ-40411813 (ADX-71149)
6995:Competitive antagonists:
6903:Polyamine site agonists:
6889:Neboglamine (nebostinel)
6458:Tooltip Kainate receptor
5974:solute carrier disorders
5611:Choline-like transporter
3742:electroneutral cation-Cl
2459:10.1089/ars.2000.2.4-665
2386:10.3389/fonc.2022.858462
1783:10.1074/jbc.274.17.11455
1643:. β-N-methyl-L-alanine (
1607:of the alpha subunit of
1546:, which is initiated by
371:internal globus pallidus
367:external globus pallidus
7977:Pentamidine isethionate
7721:Traxoprodil (CP-101606)
6960:Epipregnanolone sulfate
5512:Magnesium transporter E
3143:bicarbonate transporter
2802:10.1126/science.1120878
2318:Bading H (March 2017).
2196:Pharmacological Reviews
1618:
1594:
1575:It has been shown that
1436:It has been found that
766:response to redox state
681:transmembrane transport
16:Protein found in humans
8007:Allosteric modulators:
7942:Ipenoxazone (MLV-6976)
7597:Pethidine (meperidine)
7218:Licostinel (ACEA-1021)
7140:Apimostinel (NRX-1074)
6804:Apimostinel (NRX-1074)
6772:Glycine site agonists:
6604:Licostinel (ACEA-1021)
6315:Licostinel (ACEA-1021)
6200:Mibampator (LY-451395)
5907:Antiporter (exchanger)
2675:10.1074/jbc.M402428200
2630:10.1074/jbc.M309866200
2595:10.1074/jbc.M208704200
2488:10.1006/bbrc.2001.4703
1591:
1419:central nervous system
1381:
1331:
1258:
1244:
1236:
1113:Chr 3: 49.85 – 50.4 Mb
9118:Solute carrier family
7676:CO-101244 (PD-174494)
7392:Delucemine (NPS-1506)
7342:Alazocine (SKF-10047)
5378:metal ion transporter
4488:mitochondrial carrier
4138:type III Na-phosphate
2553:10.1007/s004240100537
2373:Frontiers in Oncology
2208:10.1124/pr.110.003889
1920:10.1089/ars.2011.4391
1611:and in expression of
1589:
1379:
1329:
1284:transmembrane domains
1255:
1242:
1234:
781:glutamate homeostasis
620:brush border membrane
7696:Radiprodil (RGH-896)
7671:Buphenine (nylidrin)
7248:Rapastinel (GLYX-13)
7063:Midafotel (d-CPPene)
6970:Pregnenolone sulfate
6894:Rapastinel (GLYX-13)
6685:Pregnenolone sulfate
6426:Pregnenolone sulfate
2709:10.1167/iovs.03-1355
2336:10.1084/jem.20161673
1613:transcription factor
1330:Monosodium glutamate
1243:Diagram of a synapse
1214:basolateral amygdala
711:striatum development
666:amino acid transport
661:platelet aggregation
641:response to nicotine
625:astrocyte projection
232:Chromosome 3 (mouse)
130:Chromosome 4 (human)
6927:-Hydroxycholesterol
6738:Homoquinolinic acid
6711:Main site agonists:
6469:Main site agonists:
6063:5-Fluorowillardiine
6060:Main site agonists:
5545:Ammonia transporter
4440:Na/(Ca-K) exchanger
2794:2006Sci...311.1921K
2757:10.1038/nature04209
2749:2005Natur.437.1173R
2277:Nature Neuroscience
2071:(11–12): 2195–209.
2027:10.7554/eLife.02523
1624:Parkinson's disease
1619:Parkinson's Disease
1595:Alzheimer's Disease
676:leukocyte migration
391:gingival epithelium
271:3 C|3 21.72 cM
94:SLC7A11 - orthologs
7275:Diethylenetriamine
6954:prasterone sulfate
6729:Homocysteic acid (
6472:5-Bromowillardiine
5990:Glutamate receptor
5692:Folate transporter
3113:heavy subunits of
2874:, which is in the
1664:Peripheral Cancers
1592:
1502:of neurons in the
1413:Clinical relevancy
1382:
1332:
1286:consisting of 501
1259:
1245:
1237:
951:ENSMUSG00000027737
634:Biological process
573:Cellular component
542:Molecular function
449:epithelium of lens
9100:
9099:
9094:
9093:
9068:
9067:
9017:
8918:
8841:
8737:
8696:
8695:
8389:
8388:
8050:
8049:
7901:
7857:Trichloroethylene
7802:Ethanol (alcohol)
7167:
7110:4-Cl-KYN (AV-101)
6878:
6870:
6837:
6829:
6821:
6778:
6763:Tetrazolylglycine
6732:
6670:Ethanol (alcohol)
6659:sodium thiopental
6477:5-Iodowillardiine
6386:Ethanol (alcohol)
6370:sodium thiopental
5981:
5980:
5965:
5964:
5961:
5960:
5821:
5820:
5817:
5816:
5813:
5812:
5760:
5759:
5756:
5755:
5485:
5484:
5481:
5480:
4991:
4990:
4987:
4986:
4163:
4162:
4159:
4158:
3684:
3683:
3680:
3679:
2913:Membrane proteins
1517:neurotransmitters
1496:prefrontal cortex
1450:vesicular release
1222:prefrontal cortex
1162:
1161:
1158:
1157:
1131:
1130:
1096:
1095:
1075:
1074:
1049:
1048:
1028:
1027:
1002:
1001:
983:
982:
957:
956:
938:
937:
912:
911:
893:
892:
841:
840:
651:brain development
526:
525:
522:
521:
477:
476:
464:
463:
437:choroidal fissure
402:
401:
387:medulla oblongata
375:entorhinal cortex
300:
299:
199:
198:
9125:
9015:
8995:
8991:
8916:
8896:
8892:
8839:
8824:
8820:
8735:
8720:
8716:
8707:
8571:
8567:
8413:
8409:
8400:
8227:
8223:
8113:
8109:
8100:
8077:
8070:
8063:
8054:
7899:
7852:Trichloroethanol
7412:Dextromethorphan
7165:
6949:
6938:
6934:
6876:
6868:
6835:
6827:
6819:
6776:
6730:
6701:
6697:
6459:
6455:
6290:Fanapanel (MPQX)
6050:
6046:
6026:
6019:
6012:
6003:
5985:
5940:
5939:
5938:
5840:
5827:
5766:
5748:Heme transporter
5502:
5491:
5008:
4997:
4180:
4169:
3849:urea transporter
3701:
3690:
2963:
2952:
2948:
2937:
2917:carrier proteins
2906:
2899:
2892:
2883:
2864:
2846:
2821:
2788:(5769): 1921–4.
2776:
2743:(7062): 1173–8.
2730:
2720:
2687:
2677:
2668:(30): 31228–36.
2652:
2642:
2632:
2623:(12): 11214–21.
2607:
2597:
2588:(47): 44765–71.
2572:
2534:
2524:
2499:
2470:
2441:
2409:
2408:
2398:
2388:
2364:
2358:
2357:
2347:
2315:
2309:
2308:
2272:
2266:
2265:
2236:
2230:
2229:
2219:
2187:
2148:
2147:
2129:
2105:
2099:
2098:
2088:
2056:
2050:
2049:
2039:
2029:
2005:
1996:
1995:
1985:
1953:
1942:
1941:
1931:
1899:
1888:
1887:
1851:
1845:
1844:
1837:
1831:
1830:
1802:
1796:
1795:
1785:
1761:
1755:
1754:
1743:
1737:
1736:
1725:
1719:
1709:
1698:
1688:
1564:Oxidative stress
1508:N-acetylcysteine
1472:trichotillomania
1462:N-acetylcysteine
1274:antiporter is a
1144:
1143:
1115:
1108:
1091:
1079:
1070:
1058:
1054:RefSeq (protein)
1044:
1032:
1023:
1011:
987:
968:
942:
923:
897:
878:
847:
771:limb development
532:
518:
509:
502:
495:
488:
473:
421:secondary oocyte
413:
411:Top expressed in
406:
383:endothelial cell
379:cartilage tissue
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
9133:
9132:
9128:
9127:
9126:
9124:
9123:
9122:
9103:
9102:
9101:
9096:
9095:
9090:
9064:
8993:
8990:
8980:
8894:
8891:
8881:
8822:
8819:
8809:
8718:
8715:
8692:
8569:
8566:
8556:
8411:
8408:
8385:
8277:Quisqualic acid
8225:
8222:
8212:
8143:Quisqualic acid
8111:
8108:
8089:
8081:
8051:
8046:
8014:
7912:Flufenamic acid
7847:Trichloroethane
7622:Rhynchophylline
7542:Methoxphenidine
7507:Levomilnacipran
7407:Dextromethadone
7332:α-Endopsychosin
6936:
6848:Dimethylglycine
6758:Quinolinic acid
6699:
6689:
6527:Quisqualic acid
6457:
6447:
6103:Quisqualic acid
6048:
6038:
6030:
5995:
5982:
5977:
5957:
5937:
5934:
5933:
5932:
5930:
5901:
5864:
5834:
5809:
5771:
5752:
5736:
5708:
5680:
5642:
5599:
5566:
5533:
5496:
5477:
5454:
5366:
5313:
5275:
5234:
5110:
5077:
5053:
5030:
5002:
4983:
4915:
4877:
4845:
4797:
4724:
4476:
4428:
4390:
4272:
4174:
4155:
4126:
4088:
4055:
3992:
3915:monocarboxylate
3903:
3865:
3837:
3794:
3730:
3695:
3676:
3603:
3530:
3509:Na/Ca exchanger
3497:
3408:
3282:
3204:
3131:
3102:
3014:
2957:
2942:
2931:
2910:
2867:
2824:
2779:
2733:
2690:
2655:
2610:
2575:
2541:PflĂĽgers Archiv
2537:
2502:
2473:
2444:
2422:
2418:
2416:Further reading
2413:
2412:
2366:
2365:
2361:
2317:
2316:
2312:
2274:
2273:
2269:
2238:
2237:
2233:
2189:
2188:
2151:
2107:
2106:
2102:
2058:
2057:
2053:
2007:
2006:
1999:
1955:
1954:
1945:
1901:
1900:
1891:
1853:
1852:
1848:
1839:
1838:
1834:
1804:
1803:
1799:
1776:(17): 11455–8.
1763:
1762:
1758:
1745:
1744:
1740:
1727:
1726:
1722:
1710:
1701:
1689:
1680:
1675:
1666:
1653:
1633:
1621:
1605:phosphorylation
1597:
1573:
1556:oligodendrocyte
1538:The release of
1536:
1488:
1434:
1415:
1387:
1356:
1324:
1300:
1264:
1250:
1153:View/Edit Mouse
1148:View/Edit Human
1111:
1104:
1101:Location (UCSC)
1087:
1066:
1040:
1019:
932:ENSG00000151012
825:
696:visual learning
629:
600:plasma membrane
568:
554:protein binding
514:
504:
503:
497:
496:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
9131:
9129:
9121:
9120:
9115:
9105:
9104:
9098:
9097:
9092:
9091:
9073:
9070:
9069:
9066:
9065:
9063:
9062:
9057:
9052:
9047:
9042:
9037:
9028:
9027:
9012:
9007:
8998:
8996:
8988:
8982:
8981:
8979:
8978:
8966:
8961:
8956:
8951:
8946:
8941:
8936:
8927:
8926:
8921:
8913:
8908:
8899:
8897:
8889:
8883:
8882:
8880:
8879:
8874:
8869:
8864:
8859:
8854:
8845:
8844:
8836:
8827:
8825:
8817:
8811:
8810:
8808:
8807:
8802:
8797:
8792:
8787:
8782:
8773:
8772:
8767:
8755:
8750:
8745:
8740:
8732:
8723:
8721:
8713:
8704:
8698:
8697:
8694:
8693:
8691:
8690:
8685:
8673:
8668:
8663:
8658:
8653:
8648:
8643:
8634:
8633:
8628:
8623:
8618:
8613:
8608:
8603:
8598:
8593:
8588:
8583:
8574:
8572:
8564:
8558:
8557:
8555:
8554:
8549:
8537:
8532:
8527:
8522:
8517:
8512:
8507:
8502:
8493:
8492:
8480:
8475:
8470:
8465:
8460:
8455:
8450:
8445:
8440:
8435:
8430:
8425:
8416:
8414:
8406:
8397:
8391:
8390:
8387:
8386:
8384:
8383:
8378:
8373:
8368:
8363:
8358:
8353:
8348:
8336:
8331:
8326:
8321:
8316:
8311:
8306:
8301:
8292:
8291:
8279:
8274:
8269:
8264:
8259:
8254:
8249:
8244:
8239:
8230:
8228:
8220:
8214:
8213:
8211:
8210:
8205:
8200:
8195:
8190:
8185:
8180:
8171:
8170:
8165:
8160:
8155:
8150:
8145:
8140:
8135:
8130:
8125:
8116:
8114:
8106:
8097:
8091:
8090:
8082:
8080:
8079:
8072:
8065:
8057:
8048:
8047:
8045:
8044:
8037:
8030:
8019:
8016:
8015:
8013:
8012:
8000:
7999:
7989:
7984:
7979:
7974:
7969:
7964:
7959:
7954:
7949:
7944:
7939:
7934:
7929:
7924:
7919:
7914:
7909:
7904:
7896:
7891:
7886:
7881:
7869:
7864:
7859:
7854:
7849:
7844:
7839:
7834:
7829:
7824:
7822:Methoxyflurane
7819:
7814:
7809:
7804:
7799:
7794:
7789:
7784:
7779:
7774:
7769:
7757:
7752:
7740:
7735:
7730:
7718:
7713:
7708:
7703:
7698:
7693:
7688:
7683:
7678:
7673:
7668:
7663:
7654:
7649:
7644:
7639:
7634:
7629:
7624:
7619:
7614:
7609:
7604:
7599:
7594:
7589:
7584:
7579:
7574:
7569:
7567:Nitromemantine
7564:
7559:
7554:
7549:
7544:
7539:
7534:
7529:
7524:
7519:
7514:
7509:
7504:
7502:Levomethorphan
7499:
7494:
7489:
7484:
7479:
7474:
7469:
7464:
7459:
7454:
7449:
7444:
7439:
7434:
7429:
7424:
7422:Dieticyclidine
7419:
7414:
7409:
7404:
7402:Dextrallorphan
7399:
7394:
7389:
7384:
7379:
7374:
7369:
7364:
7359:
7357:Argiotoxin-636
7354:
7349:
7344:
7339:
7334:
7329:
7324:
7319:
7314:
7309:
7304:
7299:
7294:
7282:
7277:
7272:
7270:Diaminopropane
7267:
7262:
7250:
7245:
7240:
7235:
7230:
7225:
7220:
7215:
7210:
7205:
7200:
7198:Kynurenic acid
7195:
7190:
7185:
7180:
7175:
7170:
7162:
7157:
7152:
7147:
7142:
7137:
7132:
7127:
7122:
7117:
7112:
7100:
7095:
7090:
7085:
7080:
7075:
7070:
7065:
7060:
7055:
7050:
7045:
7040:
7035:
7030:
7025:
7020:
7015:
7010:
7005:
7000:
6988:
6987:
6982:
6977:
6972:
6967:
6962:
6957:
6944:
6929:
6913:
6908:
6896:
6891:
6886:
6881:
6873:
6865:
6860:
6855:
6850:
6845:
6840:
6832:
6824:
6816:
6811:
6806:
6801:
6796:
6791:
6786:
6781:
6765:
6760:
6755:
6750:
6745:
6740:
6735:
6726:
6721:
6716:
6704:
6702:
6691:
6690:
6688:
6687:
6682:
6677:
6672:
6667:
6662:
6641:
6636:
6631:
6626:
6621:
6616:
6611:
6606:
6601:
6599:Kynurenic acid
6596:
6591:
6586:
6581:
6576:
6571:
6562:
6561:
6556:
6551:
6546:
6541:
6529:
6524:
6519:
6514:
6509:
6504:
6499:
6494:
6489:
6484:
6479:
6474:
6462:
6460:
6449:
6448:
6446:
6445:
6433:
6428:
6423:
6418:
6413:
6408:
6403:
6398:
6393:
6388:
6383:
6378:
6373:
6352:
6347:
6342:
6337:
6332:
6327:
6322:
6317:
6312:
6307:
6305:Kynurenic acid
6302:
6297:
6292:
6287:
6282:
6277:
6272:
6267:
6262:
6257:
6248:
6247:
6242:
6237:
6232:
6227:
6222:
6217:
6212:
6207:
6202:
6197:
6192:
6187:
6182:
6177:
6172:
6167:
6162:
6157:
6152:
6147:
6142:
6137:
6132:
6127:
6122:
6117:
6105:
6100:
6095:
6090:
6085:
6080:
6075:
6070:
6065:
6053:
6051:
6040:
6039:
6031:
6029:
6028:
6021:
6014:
6006:
6000:
5997:
5996:
5988:
5979:
5978:
5970:
5967:
5966:
5963:
5962:
5959:
5958:
5956:
5955:
5950:
5945:
5944:
5943:
5935:
5917:
5911:
5909:
5903:
5902:
5900:
5899:
5898:
5897:
5892:
5882:
5877:
5872:
5867:
5862:
5858:
5852:
5850:
5836:
5835:
5830:
5823:
5822:
5819:
5818:
5815:
5814:
5811:
5810:
5808:
5807:
5802:
5797:
5792:
5787:
5782:
5776:
5773:
5772:
5769:
5762:
5761:
5758:
5757:
5754:
5753:
5751:
5750:
5744:
5742:
5738:
5737:
5735:
5734:
5733:
5732:
5727:
5716:
5714:
5710:
5709:
5707:
5706:
5705:
5704:
5699:
5688:
5686:
5682:
5681:
5679:
5678:
5677:
5676:
5671:
5666:
5661:
5650:
5648:
5644:
5643:
5641:
5640:
5639:
5638:
5633:
5628:
5623:
5618:
5607:
5605:
5601:
5600:
5598:
5597:
5596:
5595:
5590:
5585:
5574:
5572:
5568:
5567:
5565:
5564:
5563:
5562:
5557:
5552:
5541:
5539:
5535:
5534:
5532:
5531:
5530:
5529:
5524:
5519:
5508:
5506:
5498:
5497:
5494:
5487:
5486:
5483:
5482:
5479:
5478:
5476:
5475:
5474:
5473:
5462:
5460:
5456:
5455:
5453:
5452:
5451:
5450:
5445:
5440:
5435:
5430:
5425:
5420:
5415:
5410:
5405:
5400:
5395:
5390:
5385:
5374:
5372:
5368:
5367:
5365:
5364:
5363:
5362:
5357:
5352:
5347:
5342:
5337:
5332:
5321:
5319:
5315:
5314:
5312:
5311:
5310:
5309:
5304:
5299:
5294:
5283:
5281:
5277:
5276:
5274:
5273:
5272:
5271:
5263:
5258:
5253:
5242:
5240:
5236:
5235:
5233:
5232:
5231:
5230:
5225:
5220:
5215:
5208:
5207:
5206:
5201:
5196:
5189:
5188:
5187:
5182:
5175:
5174:
5173:
5168:
5163:
5158:
5151:
5150:
5149:
5144:
5139:
5134:
5129:
5118:
5116:
5112:
5111:
5109:
5108:
5107:
5106:
5101:
5096:
5085:
5083:
5079:
5078:
5076:
5075:
5074:
5073:
5061:
5059:
5055:
5054:
5052:
5051:
5050:
5049:
5038:
5036:
5032:
5031:
5029:
5028:
5027:
5026:
5014:
5012:
5004:
5003:
5000:
4993:
4992:
4989:
4988:
4985:
4984:
4982:
4981:
4980:
4979:
4974:
4969:
4964:
4959:
4954:
4949:
4944:
4939:
4934:
4923:
4921:
4917:
4916:
4914:
4913:
4912:
4911:
4906:
4901:
4896:
4885:
4883:
4879:
4878:
4876:
4875:
4874:
4873:
4868:
4853:
4851:
4847:
4846:
4844:
4843:
4842:
4841:
4836:
4831:
4826:
4821:
4816:
4805:
4803:
4799:
4798:
4796:
4795:
4794:
4793:
4788:
4783:
4778:
4773:
4768:
4763:
4758:
4753:
4748:
4743:
4732:
4730:
4726:
4725:
4723:
4722:
4721:
4720:
4715:
4710:
4705:
4700:
4695:
4690:
4685:
4680:
4675:
4670:
4665:
4660:
4655:
4650:
4645:
4640:
4635:
4630:
4625:
4620:
4615:
4610:
4605:
4600:
4595:
4590:
4585:
4580:
4575:
4570:
4565:
4560:
4555:
4550:
4545:
4540:
4535:
4530:
4525:
4520:
4515:
4510:
4505:
4500:
4495:
4484:
4482:
4478:
4477:
4475:
4474:
4473:
4472:
4467:
4462:
4457:
4452:
4447:
4436:
4434:
4430:
4429:
4427:
4426:
4425:
4424:
4419:
4414:
4409:
4398:
4396:
4392:
4391:
4389:
4388:
4387:
4386:
4381:
4376:
4371:
4366:
4361:
4356:
4351:
4346:
4341:
4336:
4331:
4326:
4321:
4316:
4311:
4306:
4301:
4296:
4291:
4280:
4278:
4274:
4273:
4271:
4270:
4269:
4268:
4256:
4255:
4254:
4249:
4242:
4241:
4240:
4233:
4232:
4231:
4226:
4219:
4218:
4217:
4212:
4207:
4202:
4197:
4186:
4184:
4176:
4175:
4172:
4165:
4164:
4161:
4160:
4157:
4156:
4154:
4153:
4152:
4151:
4146:
4140:cotransporter
4134:
4132:
4128:
4127:
4125:
4124:
4123:
4122:
4117:
4112:
4096:
4094:
4090:
4089:
4087:
4086:
4085:
4084:
4079:
4074:
4063:
4061:
4057:
4056:
4054:
4053:
4052:
4051:
4046:
4041:
4036:
4031:
4026:
4021:
4016:
4011:
4000:
3998:
3994:
3993:
3991:
3990:
3989:
3988:
3983:
3978:
3973:
3968:
3963:
3958:
3953:
3948:
3943:
3938:
3933:
3928:
3923:
3911:
3909:
3905:
3904:
3902:
3901:
3900:
3899:
3894:
3889:
3884:
3873:
3871:
3867:
3866:
3864:
3863:
3862:
3861:
3856:
3845:
3843:
3839:
3838:
3836:
3835:
3834:
3833:
3828:
3823:
3818:
3813:
3802:
3800:
3796:
3795:
3793:
3792:
3791:
3790:
3785:
3780:
3775:
3770:
3765:
3760:
3755:
3750:
3744:cotransporter
3738:
3736:
3732:
3731:
3729:
3728:
3727:
3726:
3718:
3707:
3705:
3697:
3696:
3693:
3686:
3685:
3682:
3681:
3678:
3677:
3675:
3674:
3669:
3664:
3659:
3654:
3653:
3652:
3647:
3642:
3637:
3632:
3627:
3622:
3611:
3609:
3605:
3604:
3602:
3601:
3600:
3599:
3594:
3589:
3584:
3579:
3574:
3569:
3564:
3559:
3554:
3549:
3542:Na/H exchanger
3538:
3536:
3532:
3531:
3529:
3528:
3527:
3526:
3521:
3516:
3505:
3503:
3499:
3498:
3496:
3495:
3494:
3493:
3488:
3483:
3478:
3473:
3468:
3463:
3458:
3453:
3442:
3441:
3440:
3435:
3430:
3425:
3416:
3414:
3410:
3409:
3407:
3406:
3405:
3404:
3399:
3394:
3389:
3384:
3379:
3374:
3369:
3364:
3359:
3354:
3349:
3344:
3339:
3334:
3329:
3324:
3319:
3314:
3309:
3290:
3288:
3284:
3283:
3281:
3280:
3279:
3278:
3273:
3268:
3263:
3258:
3253:
3248:
3243:
3238:
3233:
3228:
3223:
3212:
3210:
3206:
3205:
3203:
3202:
3201:
3200:
3195:
3190:
3185:
3180:
3175:
3170:
3165:
3160:
3155:
3150:
3139:
3137:
3133:
3132:
3130:
3129:
3128:
3127:
3122:
3110:
3108:
3104:
3103:
3101:
3100:
3099:
3098:
3093:
3088:
3083:
3078:
3073:
3068:
3063:
3058:
3053:
3048:
3043:
3038:
3033:
3022:
3020:
3016:
3015:
3013:
3012:
3011:
3010:
3005:
3000:
2995:
2990:
2985:
2980:
2969:
2967:
2959:
2958:
2955:
2944:
2943:
2940:
2933:
2932:
2924:solute carrier
2911:
2909:
2908:
2901:
2894:
2886:
2866:
2865:
2822:
2777:
2731:
2703:(9): 2906–14.
2688:
2653:
2608:
2573:
2535:
2500:
2471:
2442:
2419:
2417:
2414:
2411:
2410:
2359:
2330:(3): 569–578.
2310:
2267:
2231:
2202:(3): 780–802.
2149:
2100:
2051:
1997:
1943:
1889:
1846:
1832:
1797:
1756:
1738:
1720:
1699:
1677:
1676:
1674:
1671:
1665:
1662:
1652:
1649:
1632:
1629:
1620:
1617:
1596:
1593:
1572:
1569:
1544:excitotoxicity
1535:
1532:
1487:
1484:
1480:drug addiction
1448:inhibition of
1433:
1432:Drug addiction
1430:
1414:
1411:
1386:
1383:
1367:disulfide bond
1355:
1352:
1340:synaptic cleft
1323:
1320:
1299:
1296:
1262:
1249:
1246:
1160:
1159:
1156:
1155:
1150:
1140:
1139:
1133:
1132:
1129:
1128:
1126:
1124:
1117:
1116:
1109:
1102:
1098:
1097:
1094:
1093:
1083:
1082:
1076:
1073:
1072:
1062:
1061:
1055:
1051:
1050:
1047:
1046:
1036:
1035:
1029:
1026:
1025:
1015:
1014:
1008:
1004:
1003:
1000:
999:
991:
990:
984:
981:
980:
972:
971:
965:
959:
958:
955:
954:
946:
945:
939:
936:
935:
927:
926:
920:
914:
913:
910:
909:
901:
900:
894:
891:
890:
882:
881:
875:
869:
868:
863:
858:
854:
853:
843:
842:
839:
838:
827:
826:
824:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
716:adult behavior
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
648:
643:
637:
635:
631:
630:
628:
627:
622:
617:
612:
607:
602:
597:
592:
587:
582:
576:
574:
570:
569:
567:
566:
561:
556:
551:
545:
543:
539:
538:
528:
527:
524:
523:
520:
519:
511:
510:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
425:primary oocyte
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
9130:
9119:
9116:
9114:
9111:
9110:
9108:
9089:
9088:
9084:
9080:
9077:
9071:
9061:
9058:
9056:
9053:
9051:
9048:
9046:
9043:
9041:
9038:
9036:
9033:
9030:
9029:
9026:
9023:
9019:
9013:
9011:
9008:
9006:
9003:
9000:
8999:
8997:
8992:
8983:
8977:
8974:
8970:
8967:
8965:
8962:
8960:
8957:
8955:
8952:
8950:
8947:
8945:
8942:
8940:
8937:
8935:
8932:
8929:
8928:
8925:
8922:
8920:
8914:
8912:
8909:
8907:
8904:
8901:
8900:
8898:
8893:
8884:
8878:
8875:
8873:
8870:
8868:
8865:
8863:
8860:
8858:
8855:
8853:
8850:
8847:
8846:
8843:
8837:
8835:
8832:
8829:
8828:
8826:
8821:
8812:
8806:
8803:
8801:
8798:
8796:
8793:
8791:
8788:
8786:
8783:
8781:
8778:
8775:
8774:
8771:
8768:
8766:
8763:
8759:
8756:
8754:
8751:
8749:
8746:
8744:
8741:
8739:
8733:
8731:
8728:
8725:
8724:
8722:
8717:
8708:
8705:
8703:
8699:
8689:
8686:
8684:
8681:
8677:
8674:
8672:
8669:
8667:
8664:
8662:
8659:
8657:
8654:
8652:
8649:
8647:
8644:
8642:
8639:
8636:
8635:
8632:
8629:
8627:
8624:
8622:
8619:
8617:
8614:
8612:
8609:
8607:
8604:
8602:
8601:Ibotenic acid
8599:
8597:
8594:
8592:
8589:
8587:
8584:
8582:
8579:
8576:
8575:
8573:
8568:
8559:
8553:
8550:
8548:
8545:
8541:
8538:
8536:
8533:
8531:
8528:
8526:
8523:
8521:
8518:
8516:
8513:
8511:
8508:
8506:
8503:
8501:
8498:
8495:
8494:
8491:
8488:
8484:
8481:
8479:
8476:
8474:
8471:
8469:
8466:
8464:
8461:
8459:
8456:
8454:
8451:
8449:
8448:Ibotenic acid
8446:
8444:
8441:
8439:
8436:
8434:
8431:
8429:
8426:
8424:
8421:
8418:
8417:
8415:
8410:
8401:
8398:
8396:
8392:
8382:
8379:
8377:
8374:
8372:
8369:
8367:
8364:
8362:
8359:
8357:
8354:
8352:
8349:
8347:
8344:
8340:
8337:
8335:
8332:
8330:
8327:
8325:
8322:
8320:
8317:
8315:
8312:
8310:
8307:
8305:
8302:
8300:
8297:
8294:
8293:
8290:
8287:
8283:
8280:
8278:
8275:
8273:
8272:Ibotenic acid
8270:
8268:
8265:
8263:
8260:
8258:
8255:
8253:
8250:
8248:
8245:
8243:
8240:
8238:
8235:
8232:
8231:
8229:
8224:
8215:
8209:
8206:
8204:
8201:
8199:
8196:
8194:
8191:
8189:
8188:Cyclothiazide
8186:
8184:
8181:
8179:
8176:
8173:
8172:
8169:
8166:
8164:
8161:
8159:
8156:
8154:
8151:
8149:
8146:
8144:
8141:
8139:
8138:Ibotenic acid
8136:
8134:
8131:
8129:
8126:
8124:
8121:
8118:
8117:
8115:
8110:
8101:
8098:
8096:
8092:
8088:
8085:
8078:
8073:
8071:
8066:
8064:
8059:
8058:
8055:
8043:
8042:
8038:
8036:
8035:
8031:
8029:
8028:
8025:
8021:
8020:
8017:
8011:
8008:
8005:
8002:
8001:
7997:
7993:
7992:Transcrocetin
7990:
7988:
7987:Psychotridine
7985:
7983:
7980:
7978:
7975:
7973:
7970:
7968:
7967:Niflumic acid
7965:
7963:
7960:
7958:
7955:
7953:
7950:
7948:
7945:
7943:
7940:
7938:
7935:
7933:
7930:
7928:
7925:
7923:
7920:
7918:
7915:
7913:
7910:
7908:
7905:
7903:
7897:
7895:
7892:
7890:
7887:
7885:
7882:
7880:
7877:
7873:
7870:
7868:
7865:
7863:
7860:
7858:
7855:
7853:
7850:
7848:
7845:
7843:
7840:
7838:
7835:
7833:
7830:
7828:
7827:Nitrous oxide
7825:
7823:
7820:
7818:
7815:
7813:
7810:
7808:
7805:
7803:
7800:
7798:
7795:
7793:
7792:Diethyl ether
7790:
7788:
7785:
7783:
7780:
7778:
7775:
7773:
7770:
7768:
7765:
7761:
7758:
7756:
7753:
7751:
7748:
7744:
7741:
7739:
7736:
7734:
7731:
7729:
7726:
7722:
7719:
7717:
7714:
7712:
7709:
7707:
7704:
7702:
7699:
7697:
7694:
7692:
7689:
7687:
7684:
7682:
7679:
7677:
7674:
7672:
7669:
7667:
7664:
7662:
7658:
7655:
7653:
7650:
7648:
7647:Tenocyclidine
7645:
7643:
7642:Tabernanthine
7640:
7638:
7635:
7633:
7632:Rolicyclidine
7630:
7628:
7625:
7623:
7620:
7618:
7615:
7613:
7610:
7608:
7607:Phencyclidine
7605:
7603:
7602:Phencyclamine
7600:
7598:
7595:
7593:
7590:
7588:
7585:
7583:
7580:
7578:
7575:
7573:
7570:
7568:
7565:
7563:
7560:
7558:
7555:
7553:
7550:
7548:
7545:
7543:
7540:
7538:
7537:Methoxetamine
7535:
7533:
7530:
7528:
7525:
7523:
7520:
7518:
7515:
7513:
7510:
7508:
7505:
7503:
7500:
7498:
7497:Levomethadone
7495:
7493:
7490:
7488:
7485:
7483:
7480:
7478:
7475:
7473:
7470:
7468:
7465:
7463:
7460:
7458:
7457:Fluorolintane
7455:
7453:
7450:
7448:
7445:
7443:
7440:
7438:
7435:
7433:
7430:
7428:
7425:
7423:
7420:
7418:
7415:
7413:
7410:
7408:
7405:
7403:
7400:
7398:
7395:
7393:
7390:
7388:
7385:
7383:
7380:
7378:
7375:
7373:
7370:
7368:
7365:
7363:
7360:
7358:
7355:
7353:
7350:
7348:
7345:
7343:
7340:
7338:
7335:
7333:
7330:
7328:
7325:
7323:
7320:
7318:
7315:
7313:
7310:
7308:
7305:
7303:
7300:
7298:
7295:
7293:
7290:
7286:
7283:
7281:
7278:
7276:
7273:
7271:
7268:
7266:
7263:
7261:
7258:
7254:
7251:
7249:
7246:
7244:
7241:
7239:
7236:
7234:
7231:
7229:
7226:
7224:
7221:
7219:
7216:
7214:
7211:
7209:
7206:
7204:
7201:
7199:
7196:
7194:
7191:
7189:
7186:
7184:
7181:
7179:
7176:
7174:
7171:
7169:
7163:
7161:
7158:
7156:
7153:
7151:
7148:
7146:
7143:
7141:
7138:
7136:
7133:
7131:
7128:
7126:
7123:
7121:
7118:
7116:
7113:
7111:
7108:
7104:
7101:
7099:
7096:
7094:
7091:
7089:
7086:
7084:
7081:
7079:
7076:
7074:
7071:
7069:
7066:
7064:
7061:
7059:
7056:
7054:
7051:
7049:
7046:
7044:
7041:
7039:
7038:Kaitocephalin
7036:
7034:
7031:
7029:
7026:
7024:
7021:
7019:
7016:
7014:
7011:
7009:
7006:
7004:
7001:
6999:
6996:
6993:
6990:
6989:
6986:
6983:
6981:
6978:
6976:
6973:
6971:
6968:
6966:
6963:
6961:
6958:
6955:
6951:
6945:
6942:
6935:
6930:
6928:
6926:
6921:
6917:
6914:
6912:
6909:
6907:
6904:
6900:
6897:
6895:
6892:
6890:
6887:
6885:
6882:
6880:
6874:
6872:
6866:
6864:
6861:
6859:
6856:
6854:
6851:
6849:
6846:
6844:
6841:
6839:
6833:
6831:
6825:
6823:
6817:
6815:
6812:
6810:
6807:
6805:
6802:
6800:
6797:
6795:
6792:
6790:
6787:
6785:
6782:
6780:
6773:
6769:
6766:
6764:
6761:
6759:
6756:
6754:
6751:
6749:
6746:
6744:
6743:Ibotenic acid
6741:
6739:
6736:
6734:
6727:
6725:
6722:
6720:
6717:
6715:
6712:
6709:
6706:
6705:
6703:
6698:
6692:
6686:
6683:
6681:
6678:
6676:
6673:
6671:
6668:
6666:
6663:
6660:
6656:
6655:pentobarbital
6652:
6649:
6645:
6642:
6640:
6637:
6635:
6632:
6630:
6627:
6625:
6622:
6620:
6617:
6615:
6612:
6610:
6607:
6605:
6602:
6600:
6597:
6595:
6594:Kaitocephalin
6592:
6590:
6587:
6585:
6582:
6580:
6577:
6575:
6572:
6570:
6567:
6564:
6563:
6560:
6557:
6555:
6552:
6550:
6547:
6545:
6542:
6540:
6539:Cyclothiazide
6537:
6533:
6530:
6528:
6525:
6523:
6520:
6518:
6515:
6513:
6510:
6508:
6507:Ibotenic acid
6505:
6503:
6500:
6498:
6495:
6493:
6490:
6488:
6485:
6483:
6480:
6478:
6475:
6473:
6470:
6467:
6464:
6463:
6461:
6456:
6450:
6444:
6441:
6437:
6434:
6432:
6429:
6427:
6424:
6422:
6419:
6417:
6414:
6412:
6409:
6407:
6404:
6402:
6399:
6397:
6394:
6392:
6389:
6387:
6384:
6382:
6379:
6377:
6374:
6371:
6367:
6366:pentobarbital
6363:
6360:
6356:
6353:
6351:
6348:
6346:
6343:
6341:
6338:
6336:
6333:
6331:
6328:
6326:
6323:
6321:
6318:
6316:
6313:
6311:
6308:
6306:
6303:
6301:
6300:Kaitocephalin
6298:
6296:
6293:
6291:
6288:
6286:
6283:
6281:
6278:
6276:
6273:
6271:
6268:
6266:
6263:
6261:
6258:
6256:
6253:
6250:
6249:
6246:
6243:
6241:
6238:
6236:
6233:
6231:
6228:
6226:
6223:
6221:
6218:
6216:
6213:
6211:
6208:
6206:
6203:
6201:
6198:
6196:
6193:
6191:
6188:
6186:
6183:
6181:
6178:
6176:
6173:
6171:
6168:
6166:
6163:
6161:
6158:
6156:
6153:
6151:
6148:
6146:
6143:
6141:
6138:
6136:
6133:
6131:
6128:
6126:
6123:
6121:
6120:Cyclothiazide
6118:
6116:
6113:
6109:
6106:
6104:
6101:
6099:
6096:
6094:
6093:Ibotenic acid
6091:
6089:
6086:
6084:
6081:
6079:
6076:
6074:
6071:
6069:
6066:
6064:
6061:
6058:
6055:
6054:
6052:
6047:
6041:
6037:
6034:
6027:
6022:
6020:
6015:
6013:
6008:
6007:
6004:
5998:
5994:
5991:
5986:
5976:
5975:
5968:
5954:
5951:
5949:
5946:
5942:
5926:
5923:
5922:
5921:
5918:
5916:
5913:
5912:
5910:
5908:
5904:
5896:
5893:
5891:
5888:
5887:
5886:
5883:
5881:
5878:
5876:
5873:
5871:
5868:
5866:
5859:
5857:
5854:
5853:
5851:
5849:
5848:Cotransporter
5845:
5841:
5837:
5833:
5828:
5824:
5806:
5803:
5801:
5798:
5796:
5793:
5791:
5788:
5786:
5783:
5781:
5778:
5777:
5774:
5767:
5763:
5749:
5746:
5745:
5743:
5739:
5731:
5728:
5726:
5723:
5722:
5721:
5718:
5717:
5715:
5711:
5703:
5700:
5698:
5695:
5694:
5693:
5690:
5689:
5687:
5683:
5675:
5672:
5670:
5667:
5665:
5662:
5660:
5657:
5656:
5655:
5652:
5651:
5649:
5645:
5637:
5634:
5632:
5629:
5627:
5624:
5622:
5619:
5617:
5614:
5613:
5612:
5609:
5608:
5606:
5602:
5594:
5591:
5589:
5586:
5584:
5581:
5580:
5579:
5576:
5575:
5573:
5569:
5561:
5558:
5556:
5553:
5551:
5548:
5547:
5546:
5543:
5542:
5540:
5536:
5528:
5525:
5523:
5520:
5518:
5515:
5514:
5513:
5510:
5509:
5507:
5503:
5499:
5492:
5488:
5472:
5469:
5468:
5467:
5464:
5463:
5461:
5457:
5449:
5446:
5444:
5441:
5439:
5436:
5434:
5431:
5429:
5426:
5424:
5421:
5419:
5416:
5414:
5411:
5409:
5406:
5404:
5401:
5399:
5396:
5394:
5391:
5389:
5386:
5384:
5381:
5380:
5379:
5376:
5375:
5373:
5369:
5361:
5358:
5356:
5353:
5351:
5348:
5346:
5343:
5341:
5338:
5336:
5333:
5331:
5328:
5327:
5326:
5323:
5322:
5320:
5316:
5308:
5305:
5303:
5300:
5298:
5295:
5293:
5290:
5289:
5288:
5285:
5284:
5282:
5278:
5270:
5267:
5264:
5262:
5259:
5257:
5254:
5252:
5249:
5248:
5247:
5244:
5243:
5241:
5237:
5229:
5226:
5224:
5221:
5219:
5216:
5214:
5211:
5210:
5209:
5205:
5202:
5200:
5197:
5195:
5192:
5191:
5190:
5186:
5183:
5181:
5178:
5177:
5176:
5172:
5169:
5167:
5164:
5162:
5159:
5157:
5154:
5153:
5152:
5148:
5145:
5143:
5140:
5138:
5135:
5133:
5130:
5128:
5125:
5124:
5123:
5120:
5119:
5117:
5113:
5105:
5102:
5100:
5097:
5095:
5092:
5091:
5090:
5087:
5086:
5084:
5080:
5072:
5069:
5068:
5066:
5063:
5062:
5060:
5056:
5048:
5045:
5044:
5043:
5040:
5039:
5037:
5033:
5025:
5022:
5021:
5019:
5016:
5015:
5013:
5009:
5005:
4998:
4994:
4978:
4975:
4973:
4970:
4968:
4965:
4963:
4960:
4958:
4955:
4953:
4950:
4948:
4945:
4943:
4940:
4938:
4935:
4933:
4930:
4929:
4928:
4925:
4924:
4922:
4918:
4910:
4907:
4905:
4902:
4900:
4897:
4895:
4892:
4891:
4890:
4887:
4886:
4884:
4880:
4872:
4869:
4867:
4864:
4863:
4862:
4858:
4855:
4854:
4852:
4848:
4840:
4837:
4835:
4832:
4830:
4827:
4825:
4822:
4820:
4817:
4815:
4812:
4811:
4810:
4807:
4806:
4804:
4800:
4792:
4789:
4787:
4784:
4782:
4779:
4777:
4774:
4772:
4769:
4767:
4764:
4762:
4759:
4757:
4754:
4752:
4749:
4747:
4744:
4742:
4739:
4738:
4737:
4734:
4733:
4731:
4727:
4719:
4716:
4714:
4711:
4709:
4706:
4704:
4701:
4699:
4696:
4694:
4691:
4689:
4686:
4684:
4681:
4679:
4676:
4674:
4671:
4669:
4666:
4664:
4661:
4659:
4656:
4654:
4651:
4649:
4646:
4644:
4641:
4639:
4636:
4634:
4631:
4629:
4626:
4624:
4621:
4619:
4616:
4614:
4611:
4609:
4606:
4604:
4601:
4599:
4596:
4594:
4591:
4589:
4586:
4584:
4581:
4579:
4576:
4574:
4571:
4569:
4566:
4564:
4561:
4559:
4556:
4554:
4551:
4549:
4546:
4544:
4541:
4539:
4536:
4534:
4531:
4529:
4526:
4524:
4521:
4519:
4516:
4514:
4511:
4509:
4506:
4504:
4501:
4499:
4496:
4494:
4491:
4490:
4489:
4486:
4485:
4483:
4479:
4471:
4468:
4466:
4463:
4461:
4458:
4456:
4453:
4451:
4448:
4446:
4443:
4442:
4441:
4438:
4437:
4435:
4431:
4423:
4420:
4418:
4415:
4413:
4410:
4408:
4405:
4404:
4403:
4400:
4399:
4397:
4393:
4385:
4382:
4380:
4377:
4375:
4372:
4370:
4367:
4365:
4362:
4360:
4357:
4355:
4352:
4350:
4347:
4345:
4342:
4340:
4337:
4335:
4332:
4330:
4327:
4325:
4322:
4320:
4317:
4315:
4312:
4310:
4307:
4305:
4302:
4300:
4297:
4295:
4292:
4290:
4287:
4286:
4285:
4282:
4281:
4279:
4275:
4266:
4262:
4259:
4258:
4257:
4253:
4250:
4248:
4245:
4244:
4243:
4239:
4236:
4235:
4234:
4230:
4227:
4225:
4222:
4221:
4220:
4216:
4213:
4211:
4208:
4206:
4203:
4201:
4198:
4196:
4193:
4192:
4191:
4188:
4187:
4185:
4181:
4177:
4170:
4166:
4150:
4147:
4145:
4142:
4141:
4139:
4136:
4135:
4133:
4129:
4121:
4118:
4116:
4113:
4111:
4108:
4107:
4105:
4101:
4098:
4097:
4095:
4091:
4083:
4080:
4078:
4075:
4073:
4070:
4069:
4068:
4065:
4064:
4062:
4058:
4050:
4047:
4045:
4042:
4040:
4037:
4035:
4032:
4030:
4027:
4025:
4022:
4020:
4017:
4015:
4012:
4010:
4007:
4006:
4005:
4002:
4001:
3999:
3995:
3987:
3984:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3952:
3949:
3947:
3944:
3942:
3939:
3937:
3934:
3932:
3929:
3927:
3924:
3922:
3919:
3918:
3916:
3913:
3912:
3910:
3906:
3898:
3895:
3893:
3890:
3888:
3885:
3883:
3880:
3879:
3878:
3875:
3874:
3872:
3868:
3860:
3857:
3855:
3852:
3851:
3850:
3847:
3846:
3844:
3840:
3832:
3829:
3827:
3824:
3822:
3819:
3817:
3814:
3812:
3809:
3808:
3807:
3804:
3803:
3801:
3797:
3789:
3786:
3784:
3781:
3779:
3776:
3774:
3771:
3769:
3766:
3764:
3761:
3759:
3756:
3754:
3751:
3749:
3746:
3745:
3743:
3740:
3739:
3737:
3733:
3725:
3722:
3719:
3717:
3714:
3713:
3712:
3709:
3708:
3706:
3702:
3698:
3691:
3687:
3673:
3670:
3668:
3665:
3663:
3660:
3658:
3655:
3651:
3648:
3646:
3643:
3641:
3638:
3636:
3633:
3631:
3628:
3626:
3623:
3621:
3618:
3617:
3616:
3613:
3612:
3610:
3606:
3598:
3595:
3593:
3590:
3588:
3585:
3583:
3580:
3578:
3575:
3573:
3570:
3568:
3565:
3563:
3560:
3558:
3555:
3553:
3550:
3548:
3545:
3544:
3543:
3540:
3539:
3537:
3533:
3525:
3522:
3520:
3517:
3515:
3512:
3511:
3510:
3507:
3506:
3504:
3500:
3492:
3489:
3487:
3484:
3482:
3479:
3477:
3474:
3472:
3469:
3467:
3464:
3462:
3459:
3457:
3454:
3452:
3449:
3448:
3447:
3443:
3439:
3436:
3434:
3431:
3429:
3426:
3424:
3421:
3420:
3418:
3417:
3415:
3411:
3403:
3400:
3398:
3395:
3393:
3390:
3388:
3385:
3383:
3380:
3378:
3375:
3373:
3370:
3368:
3365:
3363:
3360:
3358:
3355:
3353:
3350:
3348:
3345:
3343:
3340:
3338:
3335:
3333:
3330:
3328:
3325:
3323:
3320:
3318:
3315:
3313:
3310:
3308:
3305:
3304:
3303:
3299:
3295:
3292:
3291:
3289:
3285:
3277:
3274:
3272:
3269:
3267:
3264:
3262:
3259:
3257:
3254:
3252:
3249:
3247:
3244:
3242:
3239:
3237:
3234:
3232:
3229:
3227:
3224:
3222:
3219:
3218:
3217:
3214:
3213:
3211:
3207:
3199:
3196:
3194:
3191:
3189:
3186:
3184:
3181:
3179:
3176:
3174:
3171:
3169:
3166:
3164:
3161:
3159:
3156:
3154:
3151:
3149:
3146:
3145:
3144:
3141:
3140:
3138:
3134:
3126:
3123:
3121:
3118:
3117:
3116:
3112:
3111:
3109:
3105:
3097:
3094:
3092:
3089:
3087:
3084:
3082:
3079:
3077:
3074:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3044:
3042:
3039:
3037:
3034:
3032:
3029:
3028:
3027:
3024:
3023:
3021:
3017:
3009:
3006:
3004:
3001:
2999:
2996:
2994:
2991:
2989:
2986:
2984:
2981:
2979:
2976:
2975:
2974:
2971:
2970:
2968:
2964:
2960:
2953:
2949:
2945:
2938:
2934:
2929:
2925:
2922:
2918:
2914:
2907:
2902:
2900:
2895:
2893:
2888:
2887:
2884:
2880:
2879:
2877:
2876:public domain
2873:
2862:
2858:
2854:
2850:
2845:
2840:
2837:(3): 635–48.
2836:
2832:
2828:
2823:
2819:
2815:
2811:
2807:
2803:
2799:
2795:
2791:
2787:
2783:
2778:
2774:
2770:
2766:
2762:
2758:
2754:
2750:
2746:
2742:
2738:
2732:
2728:
2724:
2719:
2714:
2710:
2706:
2702:
2698:
2694:
2689:
2685:
2681:
2676:
2671:
2667:
2663:
2659:
2654:
2650:
2646:
2641:
2636:
2631:
2626:
2622:
2618:
2614:
2609:
2605:
2601:
2596:
2591:
2587:
2583:
2579:
2574:
2570:
2566:
2562:
2558:
2554:
2550:
2547:(2): 286–96.
2546:
2542:
2536:
2532:
2528:
2523:
2518:
2515:(2): 335–44.
2514:
2510:
2506:
2501:
2497:
2493:
2489:
2485:
2482:(5): 1132–7.
2481:
2477:
2472:
2468:
2464:
2460:
2456:
2453:(4): 665–71.
2452:
2448:
2443:
2439:
2435:
2431:
2427:
2421:
2420:
2415:
2406:
2402:
2397:
2392:
2387:
2382:
2378:
2374:
2370:
2363:
2360:
2355:
2351:
2346:
2341:
2337:
2333:
2329:
2325:
2321:
2314:
2311:
2306:
2302:
2298:
2294:
2290:
2289:10.1038/nn835
2286:
2283:(5): 405–14.
2282:
2278:
2271:
2268:
2263:
2259:
2255:
2251:
2247:
2243:
2235:
2232:
2227:
2223:
2218:
2213:
2209:
2205:
2201:
2197:
2193:
2186:
2184:
2182:
2180:
2178:
2176:
2174:
2172:
2170:
2168:
2166:
2164:
2162:
2160:
2158:
2156:
2154:
2150:
2145:
2141:
2137:
2133:
2128:
2123:
2119:
2115:
2111:
2104:
2101:
2096:
2092:
2087:
2082:
2078:
2074:
2070:
2066:
2062:
2055:
2052:
2047:
2043:
2038:
2033:
2028:
2023:
2019:
2015:
2011:
2004:
2002:
1998:
1993:
1989:
1984:
1979:
1975:
1971:
1967:
1963:
1959:
1952:
1950:
1948:
1944:
1939:
1935:
1930:
1925:
1921:
1917:
1914:(5): 522–55.
1913:
1909:
1905:
1898:
1896:
1894:
1890:
1885:
1881:
1877:
1873:
1869:
1865:
1861:
1857:
1850:
1847:
1842:
1836:
1833:
1828:
1824:
1820:
1816:
1812:
1808:
1801:
1798:
1793:
1789:
1784:
1779:
1775:
1771:
1767:
1760:
1757:
1752:
1748:
1742:
1739:
1734:
1730:
1724:
1721:
1717:
1713:
1708:
1706:
1704:
1700:
1696:
1692:
1687:
1685:
1683:
1679:
1672:
1670:
1663:
1661:
1658:
1650:
1648:
1646:
1642:
1638:
1630:
1628:
1625:
1616:
1614:
1610:
1606:
1602:
1588:
1584:
1582:
1578:
1570:
1568:
1565:
1561:
1557:
1553:
1549:
1545:
1541:
1533:
1531:
1527:
1524:
1520:
1518:
1513:
1512:NMDA receptor
1509:
1505:
1501:
1497:
1493:
1492:schizophrenia
1486:Schizophrenia
1485:
1483:
1481:
1475:
1473:
1468:
1463:
1458:
1455:
1451:
1447:
1443:
1439:
1431:
1429:
1428:
1427:CNS disorders
1424:
1420:
1412:
1410:
1408:
1404:
1400:
1399:sulfasalazine
1396:
1392:
1384:
1378:
1374:
1372:
1368:
1364:
1360:
1353:
1351:
1349:
1343:
1341:
1337:
1328:
1321:
1319:
1317:
1313:
1309:
1305:
1297:
1295:
1293:
1289:
1285:
1281:
1277:
1276:heterodimeric
1272:
1268:
1265:-independent
1254:
1247:
1241:
1233:
1229:
1227:
1223:
1219:
1215:
1211:
1206:
1201:
1199:
1195:
1192:
1188:
1184:
1179:
1177:
1174:
1170:
1166:
1154:
1149:
1145:
1141:
1138:
1134:
1127:
1125:
1122:
1118:
1114:
1110:
1107:
1103:
1099:
1092:
1090:
1084:
1080:
1077:
1071:
1069:
1063:
1059:
1056:
1052:
1045:
1043:
1037:
1033:
1030:
1024:
1022:
1016:
1012:
1009:
1007:RefSeq (mRNA)
1005:
998:
997:
992:
988:
985:
979:
978:
973:
969:
966:
964:
960:
953:
952:
947:
943:
940:
934:
933:
928:
924:
921:
919:
915:
908:
907:
902:
898:
895:
889:
888:
883:
879:
876:
874:
870:
867:
864:
862:
859:
855:
852:
848:
844:
837:
833:
828:
822:
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
752:
749:
747:
744:
742:
739:
737:
734:
732:
729:
727:
724:
722:
719:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
647:
644:
642:
639:
638:
636:
633:
632:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
596:
593:
591:
588:
586:
583:
581:
578:
577:
575:
572:
571:
565:
562:
560:
557:
555:
552:
550:
547:
546:
544:
541:
540:
537:
536:Gene ontology
533:
529:
517:
512:
508:
501:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
9075:
9074:
9032:Antagonists:
9031:
9021:
9001:
8972:
8931:Antagonists:
8930:
8902:
8849:Antagonists:
8848:
8830:
8777:Antagonists:
8776:
8761:
8726:
8679:
8638:Antagonists:
8637:
8631:Talaglumetad
8577:
8543:
8497:Antagonists:
8496:
8486:
8483:Talaglumetad
8419:
8356:Dipraglurant
8351:Basimglurant
8342:
8296:Antagonists:
8295:
8285:
8233:
8175:Antagonists:
8174:
8119:
8039:
8032:
8023:
8022:
8006:
8003:
7875:
7782:Cyclopropane
7763:
7746:
7724:
7660:
7612:Propoxyphene
7582:Orphenadrine
7487:Ketobemidone
7452:Eticyclidine
7387:Coronaridine
7372:ARL-15896-AR
7288:
7256:
7168:-Cycloserine
7150:Carisoprodol
7106:
6994:
6992:Antagonists:
6991:
6924:
6919:
6902:
6830:-Cycloserine
6771:
6710:
6707:
6651:Barbiturates
6647:
6624:Selurampanel
6579:Dasolampanel
6566:Antagonists:
6565:
6535:
6468:
6465:
6439:
6376:Cyclopropane
6362:Barbiturates
6358:
6330:Selurampanel
6280:Dasolampanel
6252:Antagonists:
6251:
6235:Pramiracetam
6111:
6059:
6056:
5971:
5067:transporter
5020:transporter
4106:transporter
3917:transporter
3300:- dependent
2869:
2868:
2834:
2830:
2785:
2781:
2740:
2736:
2700:
2696:
2665:
2661:
2620:
2616:
2585:
2581:
2544:
2540:
2512:
2508:
2479:
2475:
2450:
2446:
2432:(1): 47–54.
2429:
2425:
2376:
2372:
2362:
2327:
2323:
2313:
2280:
2276:
2270:
2245:
2241:
2234:
2199:
2195:
2120:(1): 59–66.
2117:
2113:
2103:
2068:
2064:
2054:
2017:
2013:
1968:(1): 20–34.
1965:
1961:
1911:
1907:
1862:(1): 171–9.
1859:
1855:
1849:
1835:
1813:(3): 611–8.
1810:
1806:
1800:
1773:
1769:
1759:
1750:
1741:
1732:
1723:
1667:
1654:
1634:
1622:
1598:
1574:
1537:
1528:
1525:
1521:
1489:
1476:
1459:
1435:
1416:
1388:
1357:
1344:
1333:
1301:
1260:
1228:signaling.
1202:
1197:
1182:
1180:
1172:
1164:
1163:
1086:
1065:
1039:
1018:
994:
975:
949:
930:
904:
885:
865:
860:
610:cytoskeleton
605:cell surface
333:
326:
191:138,242,349
178:138,164,097
53:External IDs
8758:VU-0155,041
8683:Decoglurant
8547:Decoglurant
8381:Raseglurant
8329:Remeglurant
8314:Mavoglurant
8178:BAY 36-7620
7972:Pentamidine
7957:Minocycline
7937:Hodgkinsine
7907:Dexanabinol
7837:Sevoflurane
7691:Isoxsuprine
7686:Haloperidol
7666:Besonprodil
7627:Rimantadine
7577:Norketamine
7572:Noribogaine
7547:Milnacipran
7512:Levorphanol
7462:Gacyclidine
7432:Dizocilpine
7427:Diphenidine
7417:Dextrorphan
7337:Alaproclate
7280:Huperzine A
7233:Meprobamate
7193:Harkoseride
7088:Perzinfotel
6965:Plazinemdor
6512:Kainic acid
6497:Domoic acid
6443:Minocycline
6431:Sevoflurane
6108:Willardiine
6083:Domoic acid
4927:zinc efflux
2640:2445/181312
1856:Amino Acids
1637:neurotoxins
1631:Neurotoxins
1601:Alzheimer's
1560:glutathione
1504:hippocampus
1423:homeostasis
1407:ferroptosis
1348:Glutathione
1316:ferroptosis
1312:excitotoxin
1304:glutathione
1288:amino acids
1205:glutathione
429:granulocyte
359:optic nerve
292:50,398,063
279:49,846,975
31:Identifiers
9107:Categories
9025:AZ12216052
8765:Foliglurax
8753:VU-001,171
8666:LY-341,495
8661:LY-307,452
8616:LY-487,379
8606:LY-379,268
8525:LY-341,495
8520:LY-307,452
8468:LY-566,332
8463:LY-487,379
8453:LY-379,268
8309:LY-344,545
8289:LSN2463359
8198:LY-456,236
8193:LY-367,385
8087:modulators
8010:AGN-241751
7982:Piretanide
7932:Furosemide
7917:Flupirtine
7894:Conantokin
7889:Caroverine
7884:Bumetanide
7817:Isoflurane
7787:Desflurane
7777:Chloroform
7716:Safaprodil
7711:Ro 25-6981
7652:Tiletamine
7637:Sabeluzole
7617:Remacemide
7562:Neramexane
7532:Methorphan
7517:Loperamide
7492:Lanicemine
7477:Indantadol
7442:Esketamine
7437:Ephenidine
7397:Dexoxadrol
7362:Arketamine
7347:Amantadine
7307:3-MeO-PCMo
7285:Putrescine
7228:MDL-105519
7203:Kynurenine
7183:Gavestinel
7098:SDZ-220581
7058:MDL-100453
6941:prasterone
6911:Spermidine
6884:Milacemide
6789:ACC (ACPC)
6675:Evans blue
6639:Topiramate
6629:Tezampanel
6559:Isoflurane
6436:Talampanel
6421:Perampanel
6416:Isoflurane
6401:GYKI-53655
6396:GYKI-52466
6391:Evans blue
6355:Zonampanel
6345:Topiramate
6335:Tezampanel
6310:Kynurenine
6270:Caroverine
6265:Becampanel
6215:Oxiracetam
6115:Aniracetam
6036:modulators
5993:modulators
5953:Cl-oxalate
5948:Cl-formate
5875:Na/glucose
5065:Acetyl-CoA
2020:: e02523.
1718:, May 2017
1697:, May 2017
1673:References
1298:Regulation
1271:antiporter
1257:transport.
1226:excitatory
1210:astrocytes
1194:antiporter
1169:antiporter
337:(ortholog)
74:HomoloGene
9076:See also:
9010:Glutamate
9002:Agonists:
8924:LSP2-9166
8911:Glutamate
8903:Agonists:
8834:Glutamate
8831:Agonists:
8743:LSP2-9166
8730:Glutamate
8727:Agonists:
8702:Group III
8688:RO4491533
8596:Glutamate
8591:Eglumegad
8578:Agonists:
8552:RO4491533
8443:Glutamate
8438:Eglumegad
8420:Agonists:
8267:Glutamate
8242:ADX-47273
8234:Agonists:
8158:Ro67-7476
8153:Ro67-4853
8148:Ro01-6128
8133:Glutamate
8120:Agonists:
8024:See also:
8004:Unsorted:
7947:MDL-27266
7927:FR-115427
7922:FPL-12495
7879:ARR-15896
7807:Halothane
7797:Enflurane
7755:Magnesium
7706:Ro 8-4304
7681:Eliprodil
7592:PD-137889
7552:Morphanol
7527:Methadone
7522:Memantine
7472:Ibogamine
7447:Etoxadrol
7377:ARL-16247
7367:ARL-12495
7352:Aptiganel
7317:4-MeO-PCP
7312:3-MeO-PCP
7302:3-MeO-PCE
7265:Co 101676
7238:MRZ 2/576
7188:GV-196771
7178:Felbamate
7155:CGP-39653
7135:ACEA-1328
7130:ACEA-1011
7073:NPC-17742
7068:NPC-12626
7053:LY-274614
7048:LY-235959
7043:LY-233053
7028:CGS-19755
7023:CGP-40116
7018:CGP-39653
7013:CGP-39551
7008:CGP-37849
6998:AP5 (APV)
6899:Sarcosine
6775:β-Fluoro-
6724:Glutamate
6719:Aspartate
6708:Agonists:
6665:Enflurane
6609:LY-382884
6569:ACEA-1011
6554:Halothane
6549:Enflurane
6544:Diazoxide
6517:LY-339434
6502:Glutamate
6466:Agonists:
6411:Irampanel
6406:Halothane
6381:Enflurane
6255:ACEA-1011
6230:Piracetam
6210:ORG-26576
6205:Nooglutyl
6195:LY-503430
6190:LY-451646
6185:LY-404187
6180:LY-395153
6175:LY-392098
6160:Diazoxide
6088:Glutamate
6057:Agonists:
5972:see also
5844:Symporter
5832:Ion pumps
2248:: 58–63.
1554:leads to
1552:microglia
1540:glutamate
1500:synchrony
1442:accumbens
1403:sorafenib
1391:glutamate
1336:glutamate
1322:Glutamate
1308:regulator
1280:disulfide
1248:Structure
1191:glutamate
1089:NP_036120
1068:NP_055146
1042:NM_011990
1021:NM_014331
851:Orthologs
82:GeneCards
9060:UBP-1112
8976:ADX71743
8964:UBP-1112
8877:UBP-1112
8805:UBP-1112
8676:MGS-0039
8621:MGS-0028
8535:MGS-0039
8473:MGS-0028
8395:Group II
8339:SIB-1893
8334:SIB-1757
8324:NPS-2390
8208:NPS-2390
8168:Theanine
7952:Metaphit
7862:Urethane
7750:Hydrogen
7747:Cations:
7657:Tramadol
7482:Ketamine
7467:Ibogaine
7382:Budipine
7297:3-HO-PCP
7223:LU-73068
7213:L-701324
7208:L-689560
7115:5,7-DCKA
7103:Selfotel
6985:SAGE-718
6980:SAGE-301
6975:SAGE-201
6916:Spermine
6906:Neomycin
6871:-Alanine
6863:L-687414
6822:-Alanine
6779:-alanine
6768:Theanine
6634:Theanine
6532:SYM-2081
6340:Theanine
5941:(Band 3)
5925:Na/(Ca-K
5495:SLC41–48
5448:SLC39A14
5443:SLC39A13
5438:SLC39A12
5433:SLC39A11
5428:SLC39A10
5360:SLC38A10
5001:SLC31–40
4977:SLC30A10
4791:SLC26A11
4786:SLC26A10
4718:SLC25A46
4713:SLC25A45
4708:SLC25A44
4703:SLC25A43
4698:SLC25A42
4693:SLC25A41
4688:SLC25A40
4683:SLC25A39
4678:SLC25A38
4673:SLC25A37
4668:SLC25A36
4663:SLC25A35
4658:SLC25A34
4653:SLC25A33
4648:SLC25A32
4643:SLC25A31
4638:SLC25A30
4633:SLC25A29
4628:SLC25A28
4623:SLC25A27
4618:SLC25A26
4613:SLC25A25
4608:SLC25A24
4603:SLC25A23
4598:SLC25A22
4593:SLC25A21
4588:SLC25A20
4583:SLC25A19
4578:SLC25A18
4573:SLC25A17
4568:SLC25A16
4563:SLC25A15
4558:SLC25A14
4553:SLC25A13
4548:SLC25A12
4543:SLC25A11
4538:SLC25A10
4384:SLC22A20
4379:SLC22A19
4374:SLC22A18
4369:SLC22A17
4364:SLC22A16
4359:SLC22A15
4354:SLC22A14
4349:SLC22A13
4344:SLC22A12
4339:SLC22A11
4334:SLC22A10
4173:SLC21–30
4104:thiamine
3986:SLC16A14
3981:SLC16A13
3976:SLC16A12
3971:SLC16A11
3966:SLC16A10
3694:SLC11–20
3298:chloride
2941:By group
2853:17081983
2818:20701579
2810:16574866
2765:16189514
2727:15326101
2684:15151999
2649:14722095
2604:12235164
2569:13615456
2561:11417227
2531:11406111
2496:11302733
2467:11213471
2438:11133847
2405:35280777
2354:28209726
2297:11953750
2262:26540405
2226:22759795
2144:13562289
2136:19751785
2095:27048822
2046:24844246
1992:21564084
1938:22667998
1884:12056137
1876:21369940
1827:12763038
1792:10206947
1714:–
1693:–
1363:cysteine
1220:and the
1137:Wikidata
830:Sources:
590:membrane
8366:GRN-529
8361:Fenobam
8346:AZD9272
8282:VU-1545
8183:CPCCOEt
8095:Group I
7996:saffron
7842:Toluene
7832:Octanol
7812:Hexanol
7767:Benzene
7743:TCN-213
7738:TCN-201
7733:MPX-007
7728:MPX-004
7322:8A-PDHQ
7260:Arcaine
7253:ZD-9379
6950:sulfate
6879:-Serine
6853:Glycine
6838:-Serine
6753:Proline
6680:NS-3763
6653:(e.g.,
6644:UBP-302
6522:Proline
6364:(e.g.,
6240:S-18986
6170:IDRA-21
6155:CX-1942
6150:CX-1739
6098:Proline
5856:Na/K,Cl
5770:SLCO1–4
5730:SLC47A2
5725:SLC47A1
5702:SLC46A2
5697:SLC46A1
5674:SLC45A4
5669:SLC54A3
5664:SLC45A2
5659:SLC45A1
5636:SLC44A5
5631:SLC44A4
5626:SLC44A3
5621:SLC44A2
5616:SLC44A1
5593:SLC43A3
5588:SLC43A2
5583:SLC43A1
5527:SLC41A3
5522:SLC41A2
5517:SLC41A1
5471:SLC40A1
5423:SLC39A9
5418:SLC39A8
5413:SLC39A7
5408:SLC39A6
5403:SLC39A5
5398:SLC39A4
5393:SLC39A3
5388:SLC39A2
5383:SLC39A1
5355:SLC38A6
5350:SLC38A5
5345:SLC38A4
5340:SLC38A3
5335:SLC38A2
5330:SLC38A1
5307:SLC37A4
5302:SLC37A3
5297:SLC37A2
5292:SLC37A1
5266:SLC36A4
5261:SLC36A3
5256:SLC36A2
5251:SLC36A1
5228:SLC35E4
5223:SLC35E3
5218:SLC35E2
5213:SLC35E1
5204:SLC35D3
5199:SLC35D2
5194:SLC35D1
5185:SLC35C2
5180:SLC35C1
5171:SLC35B4
5166:SLC35B3
5161:SLC35B2
5156:SLC35B1
5147:SLC35A5
5142:SLC35A4
5137:SLC35A3
5132:SLC35A2
5127:SLC35A1
5104:SLC34A3
5099:SLC34A2
5094:SLC34A1
5071:SLC33A1
5047:SLC32A1
5024:SLC31A1
4972:SLC30A9
4967:SLC30A8
4962:SLC30A7
4957:SLC30A6
4952:SLC30A5
4947:SLC30A4
4942:SLC30A3
4937:SLC30A2
4932:SLC30A1
4909:SLC29A4
4904:SLC29A3
4899:SLC29A2
4894:SLC29A1
4871:SLC28A3
4866:SLC28A2
4861:SLC28A1
4839:SLC27A6
4834:SLC27A5
4829:SLC27A4
4824:SLC27A3
4819:SLC27A2
4814:SLC27A1
4781:SLC26A9
4776:SLC26A8
4771:SLC26A7
4766:SLC26A6
4761:SLC26A5
4756:SLC26A4
4751:SLC26A3
4746:SLC26A2
4741:SLC26A1
4533:SLC25A9
4528:SLC25A8
4523:SLC25A7
4518:SLC25A6
4513:SLC25A5
4508:SLC25A4
4503:SLC25A3
4498:SLC25A2
4493:SLC25A1
4470:SLC24A6
4465:SLC24A5
4460:SLC24A4
4455:SLC24A3
4450:SLC24A2
4445:SLC24A1
4422:SLC23A4
4417:SLC23A3
4412:SLC23A2
4407:SLC23A1
4329:SLC22A9
4324:SLC22A8
4319:SLC22A7
4314:SLC22A6
4309:SLC22A5
4304:SLC22A4
4299:SLC22A3
4294:SLC22A2
4289:SLC22A1
4265:SLCO6A1
4261:SLCO5A1
4252:SLCO4C1
4247:SLCO4A1
4238:SLCO3A1
4229:SLCO2B1
4224:SLCO2A1
4215:SLCO1C1
4210:SLCO1B4
4205:SLCO1B3
4200:SLCO1B1
4195:SLCO1A2
4149:SLC20A2
4144:SLC20A1
4120:SLC19A3
4115:SLC19A2
4110:SLC19A1
4082:SLC18A3
4077:SLC18A2
4072:SLC18A1
4049:SLC17A9
4044:SLC17A8
4039:SLC17A7
4034:SLC17A6
4029:SLC17A5
4024:SLC17A4
4019:SLC17A3
4014:SLC17A2
4009:SLC17A1
3961:SLC16A9
3956:SLC16A8
3951:SLC16A7
3946:SLC16A6
3941:SLC16A5
3936:SLC16A4
3931:SLC16A3
3926:SLC16A2
3921:SLC16A1
3897:SLC15A4
3892:SLC15A3
3887:SLC15A2
3882:SLC15A1
3859:SLC14A2
3854:SLC14A1
3831:SLC13A5
3826:SLC13A4
3821:SLC13A3
3816:SLC13A2
3811:SLC13A1
3788:SLC12A9
3783:SLC12A8
3778:SLC12A7
3773:SLC12A6
3768:SLC12A5
3763:SLC12A4
3758:SLC12A3
3753:SLC12A2
3748:SLC12A1
3721:SLC11A2
3716:SLC11A1
3650:SLC10A7
3645:SLC10A6
3640:SLC10A5
3635:SLC10A4
3630:SLC10A3
3625:SLC10A2
3620:SLC10A1
3597:SLC9A11
3592:SLC9A10
3491:SLC7A14
3486:SLC7A13
3481:SLC7A11
3476:SLC7A10
3402:SLC6A20
3397:SLC6A19
3392:SLC6A18
3387:SLC6A17
3382:SLC6A16
3377:SLC6A15
3372:SLC6A14
3367:SLC6A13
3362:SLC6A12
3357:SLC6A11
3352:SLC6A10
2956:SLC1–10
2861:7827573
2790:Bibcode
2782:Science
2773:4427026
2745:Bibcode
2718:2735043
2396:8904967
2345:5339681
2217:3400835
2086:4887533
2037:4054777
1983:3252963
1929:3545354
1716:Ensembl
1695:Ensembl
1651:Gliomas
1641:viruses
1438:cocaine
1395:erastin
1359:Cystine
1354:Cystine
1267:anionic
1187:cystine
1183:SLC7A11
1173:SLC7A11
963:UniProt
918:Ensembl
857:Species
836:QuickGO
312:pattern
86:SLC7A11
70:1347355
45:SLC7A11
38:Aliases
22:SLC7A11
8969:XAP044
8906:AMN082
8586:DCG-IV
8581:CBiPES
8540:PCCG-4
8433:DCG-IV
8428:CBiPES
7872:Xylene
7772:Butane
7145:AV-101
6858:HA-966
6145:CX-717
6135:CX-614
6130:CX-546
6125:CX-516
5018:copper
4100:folate
3587:SLC9A9
3582:SLC9A8
3577:SLC9A7
3572:SLC9A6
3567:SLC9A5
3562:SLC9A4
3557:SLC9A3
3552:SLC9A2
3547:SLC9A1
3524:SLC8A3
3519:SLC8A2
3514:SLC8A1
3471:SLC7A9
3466:SLC7A8
3461:SLC7A7
3456:SLC7A6
3451:SLC7A5
3438:SLC7A4
3433:SLC7A3
3428:SLC7A2
3423:SLC7A1
3347:SLC6A9
3342:SLC6A8
3337:SLC6A7
3332:SLC6A6
3327:SLC6A5
3322:SLC6A4
3317:SLC6A3
3312:SLC6A2
3307:SLC6A1
3296:- and
3294:sodium
3221:SLC5A1
3148:SLC4A1
3120:SLC3A1
3031:SLC2A1
2978:SLC1A1
2859:
2851:
2816:
2808:
2771:
2763:
2737:Nature
2725:
2715:
2682:
2647:
2602:
2567:
2559:
2529:
2494:
2465:
2436:
2403:
2393:
2352:
2342:
2305:659716
2303:
2295:
2260:
2224:
2214:
2142:
2134:
2093:
2083:
2044:
2034:
1990:
1980:
1936:
1926:
1882:
1874:
1825:
1790:
1657:glioma
1467:mGluRs
1401:, and
1218:retina
1216:, the
1198:SLC3A2
1167:is an
1123:search
1121:PubMed
996:Q9WTR6
977:Q9UPY5
873:Entrez
483:BioGPS
457:thymus
433:zygote
170:4q28.3
62:607933
8987:mGluR
8944:MMPIP
8888:mGluR
8816:mGluR
8748:PHCCC
8712:mGluR
8656:HYDIA
8646:CECXG
8641:APICA
8563:mGluR
8515:HYDIA
8505:CECXG
8500:APICA
8405:mGluR
8304:DMeOB
8247:CDPPB
8219:mGluR
8163:VU-71
8105:mGluR
7867:Xenon
7327:18-MC
7292:2-MDP
7120:7-CKA
7083:PEAQX
6809:B6B21
6799:AK-51
6733:-HCA)
6696:NMDAR
6619:NS102
6350:YM90K
6045:AMPAR
5920:Na/Ca
5870:Na/Cl
5741:(48):
5713:(47):
5685:(46):
5647:(45):
5604:(44):
5571:(43):
5538:(42):
5505:(41):
5459:(40):
5371:(39):
5318:(38):
5280:(37):
5239:(36):
5115:(35):
5082:(34):
5058:(33):
5035:(32):
5011:(31):
4920:(30):
4882:(29):
4850:(28):
4802:(27):
4729:(26):
4481:(25):
4433:(24):
4395:(23):
4277:(22):
4183:(21):
4131:(20):
4093:(19):
4060:(18):
3997:(17):
3908:(16):
3870:(15):
3842:(14):
3799:(13):
3735:(12):
3704:(11):
3608:(10):
2928:TC 2A
2857:S2CID
2814:S2CID
2769:S2CID
2565:S2CID
2301:S2CID
2140:S2CID
2014:eLife
1880:S2CID
1446:mGluR
1417:Many
906:26570
887:23657
866:Mouse
861:Human
832:Amigo
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
78:22684
9055:MTPG
9050:MSOP
9045:MPPG
9040:MAP4
9035:CPPG
9018:-AP4
9005:DCPG
8959:MTPG
8954:MSOP
8949:MPPG
8939:MAP4
8934:CPPG
8919:-AP4
8872:MTPG
8867:MSOP
8862:MPPG
8857:MAP4
8852:CPPG
8842:-AP4
8800:MTPG
8795:MSOP
8790:MPPG
8785:MAP4
8780:CPPG
8770:MPEP
8738:-AP4
8671:MCPG
8651:EGLU
8530:MCPG
8510:EGLU
8423:BINA
8376:MTEP
8371:MPEP
8319:MCPG
8299:CTEP
8262:DHPG
8252:CHPG
8237:ACPD
8203:MCPG
8128:DHPG
8123:ACPD
7962:MPEP
7902:-αAA
7760:Zinc
7587:PCPr
7557:NEFA
7243:PNQX
7173:DNQX
7160:CNQX
7093:PPDA
7078:PBPD
6948:DHEA
6933:DHEA
6843:DHPG
6794:ACPD
6784:ACBD
6748:NMDA
6714:AMAA
6614:NBQX
6589:GAMS
6584:DNQX
6574:CNQX
6492:ATPA
6487:AMPA
6325:PNQX
6320:NBQX
6295:GAMS
6285:DNQX
6275:CNQX
6260:ATPO
6220:PEPA
6078:BOAA
6073:AMPA
5927:) -
5915:Na/H
5885:Cl/K
5880:Na/I
5861:Na/P
5805:O4A1
5800:O431
5795:O2B1
5790:O1B3
5785:O1B1
5780:O1A2
5560:RhCG
5555:RhBG
5550:RhAG
5269:36A2
3724:11A3
3672:10A7
3667:10A3
3662:10A2
3657:10A1
3535:(9):
3502:(8):
3413:(7):
3287:(6):
3209:(5):
3136:(4):
3107:(3):
3019:(2):
2966:(1):
2849:PMID
2831:Cell
2806:PMID
2761:PMID
2723:PMID
2680:PMID
2645:PMID
2600:PMID
2557:PMID
2527:PMID
2513:1512
2492:PMID
2463:PMID
2434:PMID
2401:PMID
2350:PMID
2293:PMID
2258:PMID
2222:PMID
2132:PMID
2091:PMID
2042:PMID
1988:PMID
1934:PMID
1872:PMID
1823:PMID
1788:PMID
1645:BMAA
1639:and
1581:Nrf2
1454:NAcc
1371:BMAA
1292:cDNA
1181:The
1176:gene
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
8257:DFB
7125:ACC
7033:CPP
7003:AP7
6814:CCG
6454:KAR
5931:HCO
5929:Cl/
2839:doi
2835:127
2798:doi
2786:311
2753:doi
2741:437
2713:PMC
2705:doi
2670:doi
2666:279
2635:hdl
2625:doi
2621:279
2590:doi
2586:277
2549:doi
2545:442
2517:doi
2484:doi
2480:282
2455:doi
2391:PMC
2381:doi
2340:PMC
2332:doi
2328:214
2285:doi
2250:doi
2212:PMC
2204:doi
2122:doi
2081:PMC
2073:doi
2032:PMC
2022:doi
1978:PMC
1970:doi
1966:165
1924:PMC
1916:doi
1864:doi
1815:doi
1811:305
1778:doi
1774:274
288:End
187:End
90:OMA
66:MGI
9109::
9085:•
9081:•
9020:;
8971:;
8760:;
8678:;
8542:;
8485:;
8341:;
8284:;
7874:;
7762:;
7745:;
7723:;
7659:;
7287:;
7255:;
7105:;
6923:24
6918:;
6901:;
6770:;
6657:,
6646:;
6534:;
6438:;
6368:,
6357:;
6110:;
5846:,
3276:12
3271:11
3266:10
3198:11
3193:10
3096:14
3091:13
3086:12
3081:11
3076:10
2919::
2915:,
2855:.
2847:.
2833:.
2829:.
2812:.
2804:.
2796:.
2784:.
2767:.
2759:.
2751:.
2739:.
2721:.
2711:.
2701:45
2699:.
2695:.
2678:.
2664:.
2660:.
2643:.
2633:.
2619:.
2615:.
2598:.
2584:.
2580:.
2563:.
2555:.
2543:.
2525:.
2511:.
2507:.
2490:.
2478:.
2461:.
2449:.
2430:42
2428:.
2399:.
2389:.
2379:.
2377:12
2375:.
2371:.
2348:.
2338:.
2326:.
2322:.
2299:.
2291:.
2279:.
2256:.
2246:72
2244:.
2220:.
2210:.
2200:64
2198:.
2194:.
2152:^
2138:.
2130:.
2118:56
2116:.
2112:.
2089:.
2079:.
2069:73
2067:.
2063:.
2040:.
2030:.
2016:.
2012:.
2000:^
1986:.
1976:.
1964:.
1960:.
1946:^
1932:.
1922:.
1912:18
1910:.
1906:.
1892:^
1878:.
1870:.
1860:42
1858:.
1821:.
1809:.
1786:.
1772:.
1768:.
1749:.
1731:.
1702:^
1681:^
1655:A
1562:.
1482:.
1474:.
1409:.
1397:,
1350:.
1178:.
834:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
9016:L
8989:8
8917:L
8890:7
8840:L
8818:6
8736:L
8714:4
8565:3
8407:2
8221:5
8107:1
8076:e
8069:t
8062:v
7998:)
7994:(
7900:D
7166:D
6956:)
6952:(
6943:)
6939:(
6925:S
6877:L
6869:L
6836:D
6828:D
6820:D
6777:D
6731:L
6661:)
6372:)
6025:e
6018:t
6011:v
5936:3
5895:5
5890:4
5865:3
5863:i
4859:(
4267:)
4263:(
4102:/
3261:9
3256:8
3251:7
3246:6
3241:5
3236:4
3231:3
3226:2
3188:9
3183:8
3178:7
3173:6
3168:5
3163:4
3158:3
3153:2
3125:2
3071:9
3066:8
3061:7
3056:6
3051:5
3046:4
3041:3
3036:2
3008:7
3003:6
2998:5
2993:4
2988:3
2983:2
2930:)
2926:(
2905:e
2898:t
2891:v
2878:.
2863:.
2841::
2820:.
2800::
2792::
2775:.
2755::
2747::
2729:.
2707::
2686:.
2672::
2651:.
2637::
2627::
2606:.
2592::
2571:.
2551::
2533:.
2519::
2498:.
2486::
2469:.
2457::
2451:2
2440:.
2407:.
2383::
2356:.
2334::
2307:.
2287::
2281:5
2264:.
2252::
2228:.
2206::
2146:.
2124::
2097:.
2075::
2048:.
2024::
2018:3
1994:.
1972::
1940:.
1918::
1886:.
1866::
1843:.
1829:.
1817::
1794:.
1780::
1753:.
1735:.
1263:+
1189:-
212:)
109:)
92::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
