322:
299:
196:
221:
573:
328:
227:
29:
1249:
catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. .
1699:
1248:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and
55:
1369:
Comings DE, Gade-Andavolu R, Gonzalez N, Wu S, Muhleman D, Blake H, Mann MB, Dietz G, Saucier G, MacMurray JP (November 2000). "A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory".
1480:
Tucci S, Futterweit W, Concepcion ES, Greenberg DA, Villanueva R, Davies TF, Tomer Y (January 2001). "Evidence for association of polycystic ovary syndrome in caucasian women with a marker at the insulin receptor gene locus".
1442:
Berstein LM, Imyanitov EN, Suspitsin EN, Grigoriev MY, Sokolov EP, Togo A, Hanson KP, Poroshina TE, Vasiljev DA, Kovalevskij AY, Gamajunova VB (February 2001). "CYP19 gene polymorphism in endometrial cancer patients".
1580:
Modugno F, Weissfeld JL, Trump DL, Zmuda JM, Shea P, Cauley JA, Ferrell RE (October 2001). "Allelic variants of aromatase and the androgen and estrogen receptors: toward a multigenic model of prostate cancer risk".
660:
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
335:
234:
1679:
866:
157:
847:
1768:
1639:
Chen S, Zhou D, Yang C, Okubo T, Kinoshita Y, Yu B, Kao YC, Itoh T (December 2001). "Modulation of aromatase expression in human breast tissue".
1744:
1763:
1326:
1308:
52:
321:
1170:
1177:
1512:"Polymorphism of the aromatase gene in postmenopausal Italian women: distribution and correlation with bone mass and fracture risk"
298:
1563:
1546:
1602:
Bulun SE, Yang S, Fang Z, Gurates B, Tamura M, Zhou J, Sebastian S (December 2001). "Role of aromatase in endometrial disease".
1295:
1274:
220:
195:
1291:
1270:
1510:
Masi L, Becherini L, Gennari L, Amedei A, Colli E, Falchetti A, Farci M, Silvestri S, Gonnelli S, Brandi ML (May 2001).
137:
334:
233:
327:
226:
1737:
1547:"Prostate carcinoma risk and allelic variants of genes involved in androgen biosynthesis and metabolism pathways"
911:
145:
892:
1545:
Latil AG, Azzouzi R, Cancel GS, Guillaume EC, Cochan-Priollet B, Berthon PL, Cussenot O (September 2001).
1730:
209:
640:
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
124:
1149:
1145:
1141:
1116:
1112:
1108:
1104:
1100:
1090:
1086:
1082:
1078:
1054:
1050:
1046:
1017:
1013:
1009:
1005:
1001:
991:
987:
983:
979:
1664:
1627:
1468:
1395:
169:
128:, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM, cytochrome P450 family 19 subfamily A member 1
1153:
1120:
1074:
1042:
1021:
975:
1656:
1619:
1590:
1568:
1533:
1498:
1460:
1430:
1387:
117:
45:
1714:
165:
1648:
1611:
1558:
1523:
1490:
1452:
1420:
1379:
414:
345:
289:
244:
389:
572:
1652:
1615:
1383:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
695:
690:
685:
680:
664:
659:
654:
649:
644:
639:
634:
629:
624:
619:
614:
1757:
1710:
1683:
601:
1668:
1472:
1399:
28:
1631:
407:
186:
149:
173:
1331:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1313:
National Center for
Biotechnology Information, U.S. National Library of Medicine
490:
1425:
1408:
306:
203:
153:
811:
550:
428:
373:
360:
272:
259:
161:
1660:
1623:
1594:
1572:
1537:
1528:
1511:
1502:
1494:
1464:
1434:
1391:
1456:
1217:
1212:
1564:
10.1002/1097-0142(20010901)92:5<1130::aid-cncr1430>3.0.co;2-b
1344:
1201:
956:
937:
1233:
923:
878:
94:
90:
86:
82:
78:
74:
1185:
833:
1698:
796:
792:
1706:
1237:
141:
581:
1409:"Polymorphic variation in CYP19 and the risk of breast cancer"
1407:
Baxter SW, Choong DY, Eccles DM, Campbell IG (February 2001).
1345:"Entrez Gene: Cytochrome P450 family 19 subfamily A member 1"
397:
1718:
562:
722:
negative regulation of chronic inflammatory response
1134:
1073:
1035:
974:
1287:
1285:
1283:
1266:
1264:
1262:
344:
243:
16:Protein-coding gene in the species Homo sapiens
1292:GRCm38: Ensembl release 89: ENSMUSG00000032274
1230:Cytochrome P450 family 19 subfamily A member 1
1738:
8:
737:negative regulation of macrophage chemotaxis
1271:GRCh38: Ensembl release 89: ENSG00000137869
1745:
1731:
1680:United States National Library of Medicine
1070:
971:
807:
777:positive regulation of estradiol secretion
597:
385:
284:
181:
63:
1562:
1527:
1424:
1236:that in humans is encoded by the CYP19A1
1678:This article incorporates text from the
1258:
18:
349:
310:
305:
248:
207:
202:
7:
1695:
1693:
1717:. You can help Knowledge (XXG) by
1131:
1032:
947:
928:
902:
883:
857:
838:
567:
485:
423:
402:
14:
1384:10.1034/j.1399-0004.2000.580508.x
767:testosterone biosynthetic process
1697:
571:
333:
326:
320:
297:
232:
225:
219:
194:
27:
1769:Human chromosome 15 gene stubs
696:integral component of membrane
681:endoplasmic reticulum membrane
582:More reference expression data
551:More reference expression data
1:
1653:10.1016/s0960-0760(01)00132-7
1641:J. Steroid Biochem. Mol. Biol
1616:10.1016/s0960-0760(01)00134-0
1604:J. Steroid Biochem. Mol. Biol
712:estrogen biosynthetic process
318:
217:
1764:Genes on human chromosome 15
752:female genitalia development
742:steroid biosynthetic process
665:steroid hydroxylase activity
467:subcutaneous adipose tissue
1785:
1692:
1516:J. Clin. Endocrinol. Metab
1483:J. Clin. Endocrinol. Metab
1445:J. Cancer Res. Clin. Oncol
772:androgen catabolic process
717:androgen metabolic process
645:electron transfer activity
1327:"Mouse PubMed Reference:"
1309:"Human PubMed Reference:"
1216:
1211:
1207:
1200:
1184:
1165:
1138:
1097:
1066:
1039:
998:
967:
954:
950:
935:
931:
922:
909:
905:
890:
886:
877:
864:
860:
845:
841:
832:
817:
810:
806:
790:
757:mammary gland development
600:
596:
579:
570:
561:
548:
497:
488:
435:
426:
396:
388:
384:
367:
354:
317:
296:
287:
283:
266:
253:
216:
193:
184:
180:
135:
132:
122:
115:
110:
71:
66:
49:
44:
39:
35:
26:
21:
1171:Chr 15: 51.21 – 51.34 Mb
782:electron transport chain
747:female gonad development
732:sterol metabolic process
1426:10.1093/carcin/22.2.347
1178:Chr 9: 54.07 – 54.18 Mb
650:oxidoreductase activity
1529:10.1210/jcem.86.5.7450
1495:10.1210/jcem.86.1.7274
630:monooxygenase activity
351:9 A5.3|9 29.49 cM
1457:10.1007/s004320000200
727:prostate gland growth
686:endoplasmic reticulum
521:ovarian follicle cell
210:Chromosome 15 (human)
475:left coronary artery
312:Chromosome 9 (mouse)
67:List of PDB id codes
40:Available structures
537:seminiferous tubule
463:germinal epithelium
174:CYP19A1 - orthologs
1705:This article on a
1682:, which is in the
912:ENSMUSG00000032274
762:uterus development
705:Biological process
674:Cellular component
655:aromatase activity
608:Molecular function
1726:
1725:
1227:
1226:
1223:
1222:
1196:
1195:
1161:
1160:
1128:
1127:
1062:
1061:
1029:
1028:
963:
962:
944:
943:
918:
917:
899:
898:
873:
872:
854:
853:
802:
801:
625:metal ion binding
592:
591:
588:
587:
557:
556:
544:
543:
482:
481:
380:
379:
279:
278:
106:
105:
102:
101:
50:Ortholog search:
1776:
1747:
1740:
1733:
1701:
1694:
1672:
1635:
1598:
1583:Clin. Cancer Res
1576:
1566:
1541:
1531:
1506:
1476:
1438:
1428:
1403:
1355:
1354:
1352:
1351:
1341:
1335:
1334:
1323:
1317:
1316:
1305:
1299:
1289:
1278:
1268:
1209:
1208:
1180:
1173:
1156:
1132:
1123:
1071:
1067:RefSeq (protein)
1057:
1033:
1024:
972:
948:
929:
903:
884:
858:
839:
808:
615:iron ion binding
598:
584:
575:
568:
553:
505:secondary oocyte
493:
491:Top expressed in
486:
431:
429:Top expressed in
424:
403:
386:
376:
363:
352:
337:
330:
324:
313:
301:
285:
275:
262:
251:
236:
229:
223:
212:
198:
182:
176:
127:
120:
97:
64:
58:
37:
36:
31:
19:
1784:
1783:
1779:
1778:
1777:
1775:
1774:
1773:
1754:
1753:
1752:
1751:
1690:
1675:
1638:
1601:
1579:
1544:
1509:
1479:
1441:
1406:
1368:
1364:
1362:Further reading
1359:
1358:
1349:
1347:
1343:
1342:
1338:
1325:
1324:
1320:
1307:
1306:
1302:
1290:
1281:
1269:
1260:
1255:
1246:
1218:View/Edit Mouse
1213:View/Edit Human
1176:
1169:
1166:Location (UCSC)
1152:
1148:
1144:
1140:
1119:
1115:
1111:
1107:
1103:
1099:
1093:
1089:
1085:
1081:
1077:
1053:
1049:
1045:
1041:
1020:
1016:
1012:
1008:
1004:
1000:
994:
990:
986:
982:
978:
893:ENSG00000137869
786:
700:
669:
580:
549:
540:
535:
531:
527:
523:
519:
515:
511:
507:
503:
489:
478:
473:
469:
465:
461:
457:
453:
449:
445:
441:
427:
371:
358:
350:
340:
339:
338:
331:
311:
288:Gene location (
270:
257:
249:
239:
238:
237:
230:
208:
185:Gene location (
136:
123:
116:
73:
51:
17:
12:
11:
5:
1782:
1780:
1772:
1771:
1766:
1756:
1755:
1750:
1749:
1742:
1735:
1727:
1724:
1723:
1702:
1674:
1673:
1647:(1–5): 35–40.
1636:
1610:(1–5): 19–25.
1599:
1589:(10): 3092–6.
1577:
1542:
1507:
1477:
1439:
1413:Carcinogenesis
1404:
1365:
1363:
1360:
1357:
1356:
1336:
1318:
1300:
1279:
1257:
1256:
1254:
1251:
1245:
1242:
1225:
1224:
1221:
1220:
1215:
1205:
1204:
1198:
1197:
1194:
1193:
1191:
1189:
1182:
1181:
1174:
1167:
1163:
1162:
1159:
1158:
1136:
1135:
1129:
1126:
1125:
1095:
1094:
1068:
1064:
1063:
1060:
1059:
1037:
1036:
1030:
1027:
1026:
996:
995:
969:
965:
964:
961:
960:
952:
951:
945:
942:
941:
933:
932:
926:
920:
919:
916:
915:
907:
906:
900:
897:
896:
888:
887:
881:
875:
874:
871:
870:
862:
861:
855:
852:
851:
843:
842:
836:
830:
829:
824:
819:
815:
814:
804:
803:
800:
799:
788:
787:
785:
784:
779:
774:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
708:
706:
702:
701:
699:
698:
693:
688:
683:
677:
675:
671:
670:
668:
667:
662:
657:
652:
647:
642:
637:
632:
627:
622:
620:oxygen binding
617:
611:
609:
605:
604:
594:
593:
590:
589:
586:
585:
577:
576:
565:
559:
558:
555:
554:
546:
545:
542:
541:
539:
538:
534:
530:
526:
522:
518:
514:
513:primary oocyte
510:
506:
502:
498:
495:
494:
483:
480:
479:
477:
476:
472:
468:
464:
460:
456:
452:
448:
444:
440:
436:
433:
432:
420:
419:
411:
400:
394:
393:
390:RNA expression
382:
381:
378:
377:
369:
365:
364:
356:
353:
348:
342:
341:
332:
325:
319:
315:
314:
309:
303:
302:
294:
293:
281:
280:
277:
276:
268:
264:
263:
255:
252:
247:
241:
240:
231:
224:
218:
214:
213:
206:
200:
199:
191:
190:
178:
177:
134:
130:
129:
121:
113:
112:
108:
107:
104:
103:
100:
99:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1781:
1770:
1767:
1765:
1762:
1761:
1759:
1748:
1743:
1741:
1736:
1734:
1729:
1728:
1722:
1720:
1716:
1712:
1711:chromosome 15
1708:
1703:
1700:
1696:
1691:
1688:
1687:
1685:
1684:public domain
1681:
1670:
1666:
1662:
1658:
1654:
1650:
1646:
1642:
1637:
1633:
1629:
1625:
1621:
1617:
1613:
1609:
1605:
1600:
1596:
1592:
1588:
1584:
1578:
1574:
1570:
1565:
1560:
1557:(5): 1130–7.
1556:
1552:
1548:
1543:
1539:
1535:
1530:
1525:
1522:(5): 2263–9.
1521:
1517:
1513:
1508:
1504:
1500:
1496:
1492:
1488:
1484:
1478:
1474:
1470:
1466:
1462:
1458:
1454:
1450:
1446:
1440:
1436:
1432:
1427:
1422:
1418:
1414:
1410:
1405:
1401:
1397:
1393:
1389:
1385:
1381:
1378:(5): 375–85.
1377:
1373:
1367:
1366:
1361:
1346:
1340:
1337:
1332:
1328:
1322:
1319:
1314:
1310:
1304:
1301:
1297:
1293:
1288:
1286:
1284:
1280:
1276:
1272:
1267:
1265:
1263:
1259:
1252:
1250:
1243:
1241:
1239:
1235:
1231:
1219:
1214:
1210:
1206:
1203:
1199:
1192:
1190:
1187:
1183:
1179:
1175:
1172:
1168:
1164:
1157:
1155:
1151:
1147:
1143:
1137:
1133:
1130:
1124:
1122:
1118:
1114:
1110:
1106:
1102:
1096:
1092:
1088:
1084:
1080:
1076:
1072:
1069:
1065:
1058:
1056:
1052:
1048:
1044:
1038:
1034:
1031:
1025:
1023:
1019:
1015:
1011:
1007:
1003:
997:
993:
989:
985:
981:
977:
973:
970:
968:RefSeq (mRNA)
966:
959:
958:
953:
949:
946:
940:
939:
934:
930:
927:
925:
921:
914:
913:
908:
904:
901:
895:
894:
889:
885:
882:
880:
876:
869:
868:
863:
859:
856:
850:
849:
844:
840:
837:
835:
831:
828:
825:
823:
820:
816:
813:
809:
805:
798:
794:
789:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
720:
718:
715:
713:
710:
709:
707:
704:
703:
697:
694:
692:
689:
687:
684:
682:
679:
678:
676:
673:
672:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
631:
628:
626:
623:
621:
618:
616:
613:
612:
610:
607:
606:
603:
602:Gene ontology
599:
595:
583:
578:
574:
569:
566:
564:
560:
552:
547:
536:
532:
528:
524:
520:
516:
512:
508:
504:
500:
499:
496:
492:
487:
484:
474:
470:
466:
462:
458:
454:
450:
446:
442:
438:
437:
434:
430:
425:
422:
421:
418:
416:
412:
410:
409:
405:
404:
401:
399:
395:
391:
387:
383:
375:
370:
366:
362:
357:
347:
343:
336:
329:
323:
316:
308:
304:
300:
295:
291:
286:
282:
274:
269:
265:
261:
256:
246:
242:
235:
228:
222:
215:
211:
205:
201:
197:
192:
188:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
131:
126:
119:
114:
109:
98:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
1719:expanding it
1704:
1689:
1677:
1676:
1644:
1640:
1607:
1603:
1586:
1582:
1554:
1550:
1519:
1515:
1489:(1): 446–9.
1486:
1482:
1451:(2): 135–8.
1448:
1444:
1419:(2): 347–9.
1416:
1412:
1375:
1371:
1348:. Retrieved
1339:
1330:
1321:
1312:
1303:
1247:
1229:
1228:
1150:NP_001335102
1146:NP_001335101
1142:NP_001335100
1139:
1117:NP_001334185
1113:NP_001334184
1109:NP_001334183
1105:NP_001334182
1101:NP_001334181
1098:
1091:NP_001334180
1087:NP_001334179
1083:NP_001334178
1079:NP_001334177
1055:NM_001348173
1051:NM_001348172
1047:NM_001348171
1040:
1018:NM_001347256
1014:NM_001347255
1010:NM_001347254
1006:NM_001347253
1002:NM_001347252
999:
992:NM_001347251
988:NM_001347250
984:NM_001347249
980:NM_001347248
955:
936:
910:
891:
865:
846:
826:
821:
635:heme binding
517:cumulus cell
501:spermatocyte
455:tibial nerve
443:right testis
413:
406:
133:External IDs
72:
1372:Clin. Genet
471:right ovary
447:left testis
372:54,175,394
359:54,073,221
271:51,338,601
258:51,208,057
111:Identifiers
1758:Categories
1350:2018-06-07
1298:, May 2017
1277:, May 2017
1253:References
417:(ortholog)
154:HomoloGene
1709:on human
1154:NP_031836
1121:NP_112503
1075:NP_000094
1043:NM_007810
1022:NM_031226
976:NM_000103
812:Orthologs
525:spermatid
162:GeneCards
1669:33879090
1661:11850205
1624:11850203
1595:11595700
1573:11571725
1538:11344237
1503:11232039
1473:31884230
1465:11216915
1435:11181459
1400:14733771
1392:11140838
1294:–
1273:–
1244:Function
1202:Wikidata
791:Sources:
691:membrane
533:testicle
529:meninges
451:testicle
439:placenta
1632:7642211
1296:Ensembl
1275:Ensembl
1234:protein
924:UniProt
879:Ensembl
818:Species
797:QuickGO
392:pattern
250:15q21.2
166:CYP19A1
125:CYP19A1
118:Aliases
22:CYP19A1
1667:
1659:
1630:
1622:
1593:
1571:
1551:Cancer
1536:
1501:
1471:
1463:
1433:
1398:
1390:
1188:search
1186:PubMed
957:P28649
938:P11511
834:Entrez
563:BioGPS
509:zygote
142:107910
1713:is a
1665:S2CID
1628:S2CID
1469:S2CID
1396:S2CID
1232:is a
867:13075
827:Mouse
822:Human
793:Amigo
459:gonad
415:Mouse
408:Human
355:Start
290:Mouse
254:Start
187:Human
158:30955
150:88587
1715:stub
1707:gene
1657:PMID
1620:PMID
1591:PMID
1569:PMID
1534:PMID
1499:PMID
1461:PMID
1431:PMID
1388:PMID
1238:gene
848:1588
398:Bgee
346:Band
307:Chr.
245:Band
204:Chr.
138:OMIM
95:4KQ8
91:4GL7
87:4GL5
83:3S7S
79:3S79
75:3EQM
56:RCSB
53:PDBe
1649:doi
1612:doi
1559:doi
1524:doi
1491:doi
1453:doi
1449:127
1421:doi
1380:doi
368:End
267:End
170:OMA
146:MGI
46:PDB
1760::
1663:.
1655:.
1645:79
1643:.
1626:.
1618:.
1608:79
1606:.
1585:.
1567:.
1555:92
1553:.
1549:.
1532:.
1520:86
1518:.
1514:.
1497:.
1487:86
1485:.
1467:.
1459:.
1447:.
1429:.
1417:22
1415:.
1411:.
1394:.
1386:.
1376:58
1374:.
1329:.
1311:.
1282:^
1261:^
1240:.
795:/
374:bp
361:bp
273:bp
260:bp
168:;
164::
160:;
156::
152:;
148::
144:;
140::
93:,
89:,
85:,
81:,
77:,
1746:e
1739:t
1732:v
1721:.
1686:.
1671:.
1651::
1634:.
1614::
1597:.
1587:7
1575:.
1561::
1540:.
1526::
1505:.
1493::
1475:.
1455::
1437:.
1423::
1402:.
1382::
1353:.
1333:.
1315:.
292:)
189:)
172::
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