36:
246:
alpha subunit. At "Class II" CRP-dependent promoters, CRP binds to a DNA site that overlaps the promoter -35 element and activates transcription through two sets of protein–protein interactions: (1) an interaction between "activating region 1" of CRP and the C-terminal domain of
241:
At "Class I" CRP-dependent promoters, CRP binds to a DNA site located upstream of core promoter elements and activates transcription through protein–protein interactions between "activating region 1" of CRP and the C-terminal domain of
262:
At most CRP-dependent promoters, CRP activates transcription primarily or exclusively through a "recruitment" mechanism, in which protein–protein interactions between CRP and
71:
230:
The signal to activate CRP is the binding of cyclic AMP. Binding of cAMP to CRP leads to a long-distance signal transduction from the
76:
191:
536:
Hudson, B. P.; Quispe, J.; Lara-Gonzalez, S.; Kim, Y.; Berman, H. M.; Arnold, E.; Ebright, R. H.; Lawson, C. L. (2009).
162:
593:
218:
202:
of the genes it controls. CRP then activates transcription through direct protein–protein interactions with
251:
alpha subunit, and (2) an interaction between "activating region 2" of CRP and the N-terminal domain of
538:"Three-dimensional EM structure of an intact activator-dependent transcription initiation complex"
467:
424:
299:
255:
alpha subunit. At "Class III" CRP-dependent promoters, CRP functions together with one or more "
199:
171:
20:
569:
518:
459:
416:
377:
319:
83:
559:
549:
508:
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451:
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367:
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311:
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domain of the protein, which is responsible for interaction with specific sequences of DNA.
223:
487:"Structural basis for cAMP-mediated allosteric control of the catabolite activator protein"
194:(cAMP), which causes a conformational change that allows CRP to bind tightly to a specific
131:
564:
537:
513:
486:
412:
372:
347:
267:
263:
252:
248:
243:
203:
587:
471:
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Bott M (1997). "Anaerobic citrate metabolism and its regulation in enterobacteria".
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Popovych, N.; Tzeng, S. -R.; Tonelli, M.; Ebright, R. H.; Kalodimos, C. G. (2009).
428:
256:
100:
141:
363:
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RH. (1999). "Transcription activation by catabolite activator protein (CAP)".
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107:
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The genes regulated by CRP are mostly involved in energy metabolism, such as
554:
503:
210:
573:
522:
381:
323:
315:
463:
455:
420:
346:
Lawson CL, Swigon D, Murakami KS, Darst SA, Berman HM, Ebright RH (2004).
175:
112:
348:"Catabolite activator protein: DNA binding and transcription activation"
214:
187:
88:
95:
396:
35:
195:
227:, CRP can regulate the transcription of more than 100 genes.
137:
127:
122:
106:
94:
82:
70:
62:
54:
49:
28:
542:Proceedings of the National Academy of Sciences
491:Proceedings of the National Academy of Sciences
8:
397:"The galactose regulon of Escherichia coli"
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34:
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25:
7:
413:10.1111/j.1365-2958.1993.tb01950.x
14:
192:cyclic adenosine monophosphate
16:Regulatory protein in bacteria
1:
395:Weickert MJ, Adhya S (1993).
163:catabolite activator protein
44:Cyclic AMP Receptor Protein.
234:cAMP-binding domain to the
610:
18:
364:10.1016/j.sbi.2004.01.012
118:
33:
352:Curr. Opin. Struct. Biol
19:Not to be confused with
555:10.1073/pnas.0908782106
504:10.1073/pnas.0900595106
219:PEP group translocation
316:10.1006/jmbi.1999.3161
456:10.1007/s002030050419
154:cAMP receptor protein
29:CAMP receptor protein
548:(47): 19830–19835.
594:Bacterial proteins
266:assist binding of
172:regulatory protein
21:C-reactive protein
497:(17): 6927–6932.
270:to the promoter.
151:
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146:
40:Structure of the
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224:Escherichia coli
160:; also known as
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38:
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584:
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12:
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5:
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477:
450:(2–3): 78–88.
434:
401:Mol. Microbiol
387:
329:
310:(2): 199–213.
278:
277:
275:
272:
268:RNA polymerase
264:RNA polymerase
253:RNA polymerase
249:RNA polymerase
244:RNA polymerase
204:RNA polymerase
183:
180:
149:
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407:(2): 245–51.
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22:
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531:
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404:
400:
390:
358:(1): 10–20.
355:
351:
307:
304:J. Mol. Biol
303:
261:
259:" proteins.
257:co-activator
240:
229:
222:
208:
198:site in the
185:
167:
161:
157:
153:
152:
63:Alt. symbols
41:
221:system. In
132:Swiss-model
101:NP_417816.1
50:Identifiers
298:Busby S.,
274:References
236:C-terminal
232:N-terminal
128:Structures
123:Search for
217:, or the
211:galactose
200:promoters
72:NCBI gene
588:Category
574:19903881
523:19359484
472:22913073
382:15102444
324:10550204
176:bacteria
142:InterPro
565:2775702
514:2678429
464:9133329
429:6872903
421:7934815
373:2765107
300:Ebright
215:citrate
188:protein
182:Protein
170:) is a
138:Domains
108:UniProt
42:E. coli
572:
562:
521:
511:
470:
462:
427:
419:
380:
370:
322:
190:binds
113:P0ACJ8
96:RefSeq
77:947867
55:Symbol
468:S2CID
425:S2CID
570:PMID
519:PMID
460:PMID
417:PMID
378:PMID
320:PMID
186:CRP
89:1I5Z
560:PMC
550:doi
546:106
509:PMC
499:doi
495:106
452:doi
448:167
409:doi
368:PMC
360:doi
312:doi
308:293
196:DNA
174:in
168:CAP
158:CRP
84:PDB
66:CAP
58:CRP
590::
568:.
558:.
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540:.
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415:.
405:10
403:.
399:.
376:.
366:.
356:14
354:.
350:.
332:^
318:.
306:.
282:^
213:,
206:.
178:.
166:,
576:.
552::
525:.
501::
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454::
431:.
411::
384:.
362::
326:.
314::
156:(
23:.
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