1489:
cyclin B1. Previous work done has shown that cyclin B1 is essential for tumor cell survival and proliferation and that a decrease in expression levels only leads to tumor-specific and not normal cell death. Reduction of cyclin B1 can stop cells in the G2 phase of the cell cycle and triggers cell death by preventing the chromosomes from condensing and aligning. The specific downregulation of cyclin B1, however, did not influence other molecules that facilitated the transition from the G2 to M phase such as Cdk1, Cdc25c, Plk1 and cyclin A. Therefore the delivery of a therapeutic gene to correct these mutations is a viable treatment option for tumor suppression.
331:
308:
1476:
become immortalized and aneuploid which can contribute to the chromosomal instability and the aggressive nature of certain cancers. These high levels of cyclin B1 can also be associated to the extent of tumor invasion and aggressiveness therefore concentration of cyclin B1 can be used to determine the prognosis of cancer patients. For example, an increase in expression of cyclin B1/cdc2 is significantly higher in breast tumor tissue and shown to increase lymph node metastasis in breast cancer.
205:
230:
582:
3680:
337:
236:
42:
1394:
3665:
1488:
While the exact mechanism that explains how cyclin B1 becomes overexpressed is not very well understood, previous work has shown that down regulation of cyclin B1 can lead to tumor regression. A possible treatment option for tumor suppression is to deliver gene or protein to target the degradation of
1479:
Cyclin B1 can reside in the nucleus or the cytoplasm which can have an effect on the malignant potential of cyclin B1 when overexpressed in each location. Nuclear-dominant expression of cyclin B1 leads to poorer prognosis due to its weak activity compared to cytoplasmic cyclin B1. This trend has been
1471:
One of the hallmarks of cancer is the lack of regulation in the cell cycle. The role of cyclin B1 is to transition the cell from G2 to M phase but becomes unregulated in cancer cells where overexpression of cyclin B1 can lead to uncontrolled cell growth by binding to its partner Cdks. Binding of Cdks
1519:
Studies in non-small cell lung cancer demonstrated that high levels of cyclin B1 are associated with poorer prognosis. The study also found that this correlation between expression levels was only found in patients with squamous cell carcinoma. This finding indicates the possibility of using cyclin
1475:
Previous work has shown that high cyclin B1 expression levels are found in variety of cancers such as breast, cervical, gastric, colorectal, head and neck squamous cell, non-small-cell lung cancer, colon, prostate, oral and esophageal. High expression levels are usually seen before the tumor cells
1417:
Another mechanism by which cyclin B1-Cdk1 activity is regulated is through subcellular localization. Before mitosis almost all cyclin B1 in the cell is located in the cytoplasm, but in late prophase it relocates to the nucleus. This is regulated by the phosphorylation of cyclin B1, in contrast to
1510:
Cyclin B1 expression levels can be used as a tool to determine prognosis of patients with breast cancers. The intracellular concentration can have important implications for cancer prognosis. High levels of nuclear cyclin B1 is associated with high tumor grade, larger tumor size and higher
1414:-Cdk, which functions before cyclin B1-Cdk in the cell cycle. Active Cdk1 is also capable of phosphorylating and activating Cdc25 and thus promote its own activation, resulting in a positive feedback loop. Once cyclin B1-Cdk1 is activated, it remains stably active for the rest of mitosis.
1385:. Phosphorylation of the lamins by cyclin B1-Cdk1 causes them to dissociate, compromising the structural integrity of the nuclear envelope so that it breaks down. The destruction of the nuclear envelope is important because it allows the mitotic spindle to access the chromosomes.
1497:
In early stages of cancer when the cyclin B1 concentration is high, it is recognized by the immune system, leading to the production of antibodies and T cells. It would then be possible to take advantage of this to monitor the immune response for early cancer detection. An
68:
1472:
can lead to phosphorylation of other substrates at inappropriate time and unregulated proliferation. This is a consequence of p53, tumor suppressor protein, being inactivated. Wild-type p53 have been shown to suppress cyclin B1 expression.
1401:
Like all cyclins, levels of cyclin B1 oscillate over the course of the cell cycle. Just prior to mitosis, a large amount of cyclin B1 is present in the cell, but it is inactive due to phosphorylation of Cdk1 by the
2695:
Nozoe T, Korenaga D, Kabashima A, Ohga T, Saeki H, Sugimachi K (March 2002). "Significance of cyclin B1 expression as an independent prognostic indicator of patients with squamous cell carcinoma of the esophagus".
1418:
phosphorylation of Cdk1 regulating the activity of the complex. Phosphorylation of cyclin B1 causes it to be imported to the nucleus, and phosphorylation also prevents export from the nucleus by blocking the
2154:
Vairapandi M, Balliet AG, Hoffman B, Liebermann DA (September 2002). "GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress".
1380:
Another important function of the cyclin B1-Cdk1 complex is to break down the nuclear envelope. The nuclear envelope is a membranous structure containing large protein complexes supported by a network of
2659:
Winters ZE, Hunt NC, Bradburn MJ, Royds JA, Turley H, Harris AL, Norbury CJ (December 2001). "Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer. association with prognosis".
1355:(MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript that is expressed predominantly during G2/M phase of the
2895:
Bailly E, Pines J, Hunter T, Bornens M (1992). "Cytoplasmic accumulation of cyclin B1 in human cells: association with a detergent-resistant compartment and with the centrosome".
1366:
loops ensure that once the cyclin B1-Cdk1 complex is activated, it is not deactivated. Cyclin B1-Cdk1 is involved in the early events of mitosis, such as chromosome condensation,
2815:
Soria JC, Jang SJ, Khuri FR, Hassan K, Liu D, Hong WK, Mao L (August 2000). "Overexpression of cyclin B1 in early-stage non-small cell lung cancer and its clinical implication".
344:
243:
2392:"Expression of the G2-M checkpoint regulators cyclin B1 and cdc2 in nonmalignant and malignant human breast lesions: immunocytochemical and quantitative image analyses"
3244:"Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics"
2961:
Pines J, Hunter T (1989). "Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2".
2764:
Egloff AM, Weissfeld J, Land SR, Finn OJ (December 2005). "Evaluation of anticyclin B1 serum antibody as a diagnostic and prognostic biomarker for lung cancer".
3720:
1626:
Sartor H, Ehlert F, Grzeschik KH, Müller R, Adolph S (Aug 1992). "Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31 and 5q12, respectively".
2474:
Mashal RD, Lester S, Corless C, Richie JP, Chandra R, Propert KJ, Dutta A (September 1996). "Expression of cell cycle-regulated proteins in prostate cancer".
3213:
Piaggio G, Farina A, Perrotti D, Manni I, Fuschi P, Sacchi A, Gaetano C (1995). "Structure and growth-dependent regulation of the human cyclin B1 promoter".
1397:
Cyclin B1 accumulates throughout the cell cycle but must be activated. It is degraded at the end of mitosis and accumulates again during the next cell cycle.
2291:(May 2002). "Immune recognition of cyclin B1 as a tumor antigen is a result of its overexpression in human tumors that is caused by non-functional p53".
1050:
166:
2924:
Galaktionov K, Beach D (1991). "Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins".
4012:
3906:
1031:
3679:
1362:
Cyclin B1 contributes to the switch-like all or none behavior of the cell in deciding to commit to mitosis. Its activation is well-regulated, and
2021:(1989). "Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2".
1926:"Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest"
1608:
3644:
2848:"Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?"
1778:
4218:
3952:
1590:
3000:"Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity"
1410:. Cdc25 is always present in the cell but must be activated by phosphorylation. A possible trigger for activation is phosphorylation by
330:
2501:
Kushner J, Bradley G, Young B, Jordan RC (February 1999). "Aberrant expression of cyclin A and cyclin B1 proteins in oral carcinoma".
2200:"RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis"
1262:
3713:
1373:
Once activated, cyclin B1-Cdk1 promotes several of the events of early mitosis. The active complex phosphorylates and activates 13S
1269:
3491:
Kolesnitchenko V, Wahl LM, Tian H, Sunila I, Tani Y, Hartmann DP, Cossman J, Raffeld M, Orenstein J, Samelson LE, Cohen DI (1995).
3172:"Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus"
307:
1718:
Heald R, McKeon F (May 1990). "Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis".
3546:"Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage"
3086:"Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr"
1661:
1577:
1556:
1675:
Kimura K, Hirano M, Kobayashi R, Hirano T (October 1998). "Phosphorylation and activation of 13S condensin by Cdc2 in vitro".
3664:
3366:
Zheng XF, Ruderman JV (1993). "Functional analysis of the P box, a domain in cyclin B required for the activation of Cdc25".
1573:
3405:"G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently"
229:
204:
65:
3242:
Ookata K, Hisanaga S, Bulinski JC, Murofushi H, Aizawa H, Itoh TJ, Hotani H, Okumura E, Tachibana K, Kishimoto T (1995).
1552:
3706:
2248:"Stable gene silencing of cyclin B1 in tumor cells increases susceptibility to taxol and leads to growth arrest in vivo"
146:
3043:"Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B"
4022:
1446:
1352:
343:
242:
4163:
3866:
1434:
1828:"Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal"
336:
235:
3861:
3856:
3851:
3846:
3841:
3836:
3831:
3826:
3821:
3637:
3129:"The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle"
1095:
154:
2431:
Wang A, Yoshimi N, Ino N, Tanaka T, Mori H (1997). "Overexpression of cyclin B1 in human colorectal cancers".
3287:"The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B"
3813:
2115:"Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45"
1076:
2246:
Yuan J, Krämer A, Matthess Y, Yan R, Spänkuch B, Gätje R, Knecht R, Kaufmann M, Strebhardt K (March 2006).
1502:(Enzyme-linked immunosorbent assay) can be performed to the measure the antibodies recognizing cyclin B1.
4145:
3896:
1419:
3630:
3504:
3451:
3440:"Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15"
2859:
2773:
2613:
2339:
1839:
1684:
218:
3329:
133:
1226:
1222:
1192:
1171:
1167:
3330:"Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation"
1885:"Combinatorial control of cyclin B1 nuclear trafficking through phosphorylation at multiple sites"
4158:
3963:
3391:
2986:
2949:
2883:
2797:
2582:
2541:
Suzuki T, Urano T, Miki Y, Moriya T, Akahira J, Ishida T, Horie K, Inoue S, Sasano H (May 2007).
2456:
2180:
2046:
1865:
1796:
1743:
178:
1218:
1163:
1520:
B1 expression as a prognostic marker for patients with early stage non-small cell lung cancer.
4153:
3610:
3567:
3532:
3479:
3426:
3383:
3354:
3316:
3273:
3230:
3201:
3158:
3115:
3072:
3029:
2978:
2941:
2912:
2875:
2824:
2789:
2746:
2705:
2677:
2641:
2574:
2518:
2483:
2448:
2413:
2367:
2308:
2269:
2221:
2172:
2136:
2095:
2066:"Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction"
2038:
2018:
1996:
1955:
1906:
1857:
1784:
1774:
1735:
1700:
1643:
1511:
metastasis probability, therefore a high level of cyclin B1 is a predictor of poor prognosis.
1363:
581:
126:
58:
1359:. The different transcripts result from the use of alternate transcription initiation sites.
921:
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
3600:
3592:
3557:
3522:
3512:
3469:
3459:
3416:
3375:
3344:
3306:
3298:
3263:
3255:
3222:
3191:
3183:
3148:
3140:
3105:
3097:
3062:
3054:
3019:
3011:
2970:
2933:
2904:
2867:
2781:
2736:
2669:
2631:
2621:
2564:
2554:
2510:
2440:
2403:
2357:
2347:
2300:
2259:
2211:
2164:
2126:
2085:
2077:
2030:
1986:
1945:
1937:
1896:
1847:
1766:
1727:
1692:
1635:
1367:
423:
354:
298:
253:
1973:
Yang Q, Manicone A, Coursen JD, Linke SP, Nagashima M, Forgues M, Wang XW (November 2000).
174:
3403:
O'Connor PM, Ferris DK, Pagano M, Draetta G, Pines J, Hunter T, Longo DL, Kohn KW (1993).
1808:
398:
3508:
3455:
2863:
2777:
2617:
2602:"Cyclins as markers of tumor proliferation: immunocytochemical studies in breast cancer"
2569:
2542:
2343:
1843:
1761:
Berry LD, Gould KL (1996). "Regulation of Cdc2 activity by phosphorylation at T14/Y15".
1688:
3302:
3268:
3243:
3187:
2725:"Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells"
2514:
2408:
2391:
2014:
1823:
41:
3605:
3580:
3421:
3404:
3379:
3311:
3286:
3196:
3171:
3153:
3128:
3110:
3085:
3067:
3042:
3024:
2999:
2673:
2304:
2090:
2065:
1950:
1925:
1852:
1827:
1393:
965:
960:
955:
950:
945:
940:
935:
930:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
668:
663:
658:
653:
648:
643:
638:
633:
628:
623:
4212:
4092:
3527:
3492:
3474:
3439:
3144:
3101:
3058:
3015:
2974:
2937:
2636:
2601:
2559:
2362:
2327:
2113:
Zhan Q, Antinore MJ, Wang XW, Carrier F, Smith ML, Harris CC, Fornace AJ (May 1999).
2034:
1731:
1639:
1480:
observed in esophageal cancer, head and neck squamous cell cancer and breast cancer.
1430:, again setting up a positive feedback loop that commits cyclin B1-Cdk1 to its fate.
610:
3395:
2990:
2887:
2801:
2723:
Yuan J, Yan R, Krämer A, Eckerdt F, Roller M, Kaufmann M, Strebhardt K (July 2004).
2586:
2460:
2184:
2050:
1869:
1747:
158:
4114:
2953:
2288:
416:
195:
3493:"Human immunodeficiency virus 1 envelope-initiated G2-phase programmed cell death"
1770:
1696:
182:
4135:
4104:
1613:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1595:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1423:
936:
positive regulation of cyclin-dependent protein serine/threonine kinase activity
499:
4056:
3940:
3729:
2081:
1356:
315:
212:
162:
3562:
3545:
3517:
926:
positive regulation of mitochondrial ATP synthesis coupled electron transport
4179:
4129:
4119:
3802:
3798:
3788:
3784:
3780:
3770:
3756:
3752:
2871:
2785:
2626:
1975:"Identification of a functional domain in a GADD45-mediated G2/M checkpoint"
1437:
through its APC localization sequence, permitting the cell to exit mitosis.
1374:
995:
559:
437:
382:
369:
281:
268:
170:
3464:
3226:
2879:
2828:
2793:
2750:
2741:
2724:
2709:
2681:
2578:
2543:"Nuclear cyclin B1 in human breast carcinoma as a potent prognostic factor"
2371:
2352:
2312:
2273:
2264:
2247:
2225:
2216:
2199:
2176:
2140:
2131:
2114:
2099:
2000:
1991:
1974:
1910:
1901:
1884:
1861:
3614:
3596:
3571:
3536:
3483:
3430:
3387:
3358:
3320:
3277:
3259:
3234:
3205:
3162:
3119:
3076:
3033:
2982:
2945:
2916:
2908:
2645:
2522:
2487:
2452:
2417:
2042:
1959:
1941:
1788:
1739:
1704:
1647:
1309:
4184:
4124:
4109:
4078:
4064:
3794:
3776:
3762:
3748:
3349:
1529:
1411:
1406:
kinase. The complex is activated by dephosphorylation by the phosphatase
1293:
1121:
1304:
826:
positive regulation of attachment of spindle microtubules to kinetochore
4193:
4100:
4073:
3732:
2444:
1456:
1344:
1325:
1107:
1062:
946:
regulation of cyclin-dependent protein serine/threonine kinase activity
3698:
2168:
103:
99:
95:
91:
87:
4032:
3948:
3934:
3930:
3926:
3918:
3876:
3871:
3740:
1460:
1277:
1017:
17:
2847:
1433:
At the end of mitosis, cyclin B1 is targeted for degradation by the
1924:
Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E (February 1999).
669:
cyclin-dependent protein serine/threonine kinase regulator activity
649:
cyclin-dependent protein serine/threonine kinase activator activity
4007:
4002:
3891:
3886:
3881:
3127:
Jowett JB, Planelles V, Poon B, Shah NP, Chen ML, Chen IS (1995).
2998:
He J, Choe S, Walker R, Di Marzio P, Morgan DO, Landau NR (1995).
1499:
1407:
1392:
1382:
3581:"Cyclin-binding motifs are essential for the function of p21CIP1"
2198:
Rossé C, L'Hoste S, Offner N, Picard A, Camonis J (August 2003).
1883:
Yang J, Song H, Walsh S, Bardes ES, Kornbluth S (February 2001).
980:
976:
4036:
4027:
3997:
3976:
3914:
1450:
1427:
1403:
1348:
1332:
150:
3702:
3626:
3084:
Di Marzio P, Choe S, Ebright M, Knoblauch R, Landau NR (1995).
2326:
Innocente SA, Abrahamson JL, Cogswell JP, Lee JM (March 1999).
4017:
3981:
3971:
3944:
3922:
3622:
590:
3688:: CRYSTAL STRUCTURE OF PHOSPHO-CDK2 IN COMPLEX WITH CYCLIN B
931:
positive regulation of G2/M transition of mitotic cell cycle
766:
regulation of mitotic cell cycle spindle assembly checkpoint
2064:
Kong M, Barnes EA, Ollendorff V, Donoghue DJ (March 2000).
3579:
Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A (1996).
644:
cyclin-dependent protein serine/threonine kinase activity
961:
transcription initiation from RNA polymerase II promoter
846:
positive regulation of cardiac muscle cell proliferation
406:
881:
anaphase-promoting complex-dependent catabolic process
2600:
Dutta A, Chandra R, Leiter LM, Lester S (June 1995).
571:
956:
positive regulation of cell population proliferation
4172:
4144:
4091:
4055:
4046:
3990:
3962:
3905:
3812:
3739:
2390:Kawamoto H, Koizumi H, Uchikoshi T (January 1997).
1240:
1211:
1185:
1156:
1569:
1567:
1565:
1548:
1546:
1544:
740:cyclin-dependent protein kinase holoenzyme complex
2328:"p53 regulates a G2 checkpoint through cyclin B1"
966:regulation of mitotic cell cycle phase transition
353:
252:
3544:Poon RY, Jiang W, Toyoshima H, Hunter T (1996).
2536:
2534:
2532:
2241:
2239:
2237:
2235:
781:positive regulation of fibroblast proliferation
27:Protein-coding gene in the species Homo sapiens
2385:
2383:
2381:
1574:GRCm38: Ensembl release 89: ENSMUSG00000048574
1343:Cyclin B1 is a regulatory protein involved in
756:negative regulation of protein phosphorylation
3714:
3638:
771:positive regulation of mRNA 3'-end processing
8:
3041:Re F, Braaten D, Franke EK, Luban J (1995).
791:cellular response to organic cyclic compound
1553:GRCh38: Ensembl release 89: ENSG00000134057
896:ventricular cardiac muscle cell development
4052:
3721:
3707:
3699:
3645:
3631:
3623:
3438:Sebastian B, Kakizuka A, Hunter T (1993).
991:
606:
394:
293:
190:
76:
4013:Cellular apoptosis susceptibility protein
3604:
3561:
3526:
3516:
3473:
3463:
3420:
3348:
3310:
3267:
3195:
3152:
3109:
3066:
3023:
2740:
2635:
2625:
2568:
2558:
2407:
2361:
2351:
2263:
2215:
2130:
2089:
1990:
1949:
1900:
1851:
801:positive regulation of mitotic cell cycle
2503:Journal of Oral Pathology & Medicine
3660:
1540:
1377:, which helps to condense chromosomes.
1347:. The gene product complexes with p34 (
3673:: Crystal Structure of Human Cyclin B1
1804:
1794:
1370:breakdown, and spindle pole assembly.
951:regulation of mitotic nuclear division
811:negative regulation of gene expression
31:
1484:Down regulation and tumor suppression
886:regulation of chromosome condensation
856:G2/M transition of mitotic cell cycle
654:ubiquitin-like protein ligase binding
358:
319:
314:
257:
216:
211:
7:
3170:Jackman M, Firth M, Pines J (1995).
836:mitotic nuclear membrane disassembly
941:protein-containing complex assembly
876:mitotic metaphase plate congression
3328:Xiong Y, Zhang H, Beach D (1993).
3303:10.1002/j.1460-2075.1994.tb06688.x
3188:10.1002/j.1460-2075.1995.tb07153.x
2515:10.1111/j.1600-0714.1999.tb02000.x
1237:
1208:
1182:
1153:
1131:
1112:
1086:
1067:
1041:
1022:
786:cellular response to iron(III) ion
576:
494:
432:
411:
25:
1822:Hagting A, Jackman M, Simpson K,
1422:. Cyclin B1 is phosphorylated by
1328:that in humans is encoded by the
851:positive regulation of cell cycle
3678:
3663:
3145:10.1128/JVI.69.10.6304-6313.1995
3102:10.1128/JVI.69.12.7909-7916.1995
3059:10.1128/JVI.69.11.6859-6864.1995
3016:10.1128/JVI.69.11.6705-6711.1995
2560:10.1111/j.1349-7006.2007.00444.x
1765:. Vol. 2. pp. 99–105.
580:
342:
335:
329:
306:
241:
234:
228:
203:
40:
1763:Progress in Cell Cycle Research
841:cellular response to fatty acid
796:response to mechanical stimulus
1662:"Entrez Gene: CCNB1 cyclin B1"
806:in utero embryonic development
591:More reference expression data
560:More reference expression data
1:
3422:10.1016/S0021-9258(18)53096-9
3380:10.1016/S0092-8674(05)80092-3
2674:10.1016/S0959-8049(01)00327-6
2305:10.1016/S0161-5890(02)00026-3
1853:10.1016/S0960-9822(99)80308-X
1322:G2/mitotic-specific cyclin-B1
710:microtubule organizing center
327:
226:
3497:Proc. Natl. Acad. Sci. U.S.A
3444:Proc. Natl. Acad. Sci. U.S.A
2975:10.1016/0092-8674(89)90936-7
2938:10.1016/0092-8674(91)90294-9
2846:Kino T, Chrousos GP (2004).
2606:Proc. Natl. Acad. Sci. U.S.A
2332:Proc. Natl. Acad. Sci. U.S.A
2035:10.1016/0092-8674(89)90936-7
1771:10.1007/978-1-4615-5873-6_10
1732:10.1016/0092-8674(90)90470-Y
1697:10.1126/science.282.5388.487
1640:10.1016/0888-7543(92)90190-4
1445:Cyclin B1 has been shown to
911:mitotic spindle organization
901:cellular response to hypoxia
4219:Genes on human chromosome 5
4023:Maturation promoting factor
1353:maturation-promoting factor
906:response to toxic substance
891:digestive tract development
472:stromal cell of endometrium
4235:
4164:Postreplication checkpoint
3285:Pines J, Hunter T (1994).
2433:J. Cancer Res. Clin. Oncol
468:mucosa of transverse colon
3658:
1609:"Mouse PubMed Reference:"
1591:"Human PubMed Reference:"
1308:
1303:
1299:
1292:
1276:
1257:
1244:
1215:
1204:
1189:
1160:
1149:
1138:
1134:
1119:
1115:
1106:
1093:
1089:
1074:
1070:
1061:
1048:
1044:
1029:
1025:
1016:
1001:
994:
990:
974:
609:
605:
588:
579:
570:
557:
506:
497:
444:
435:
405:
397:
393:
376:
363:
326:
305:
296:
292:
275:
262:
225:
202:
193:
189:
144:
141:
131:
124:
119:
84:
79:
62:
57:
52:
48:
39:
34:
3563:10.1074/jbc.271.22.13283
3518:10.1073/pnas.92.25.11889
816:regulation of cell cycle
2872:10.1196/annals.1321.013
2786:10.1196/annals.1358.005
2627:10.1073/pnas.92.12.5386
2082:10.1093/emboj/19.6.1378
1270:Chr 7: 41.76 – 41.76 Mb
1263:Chr 5: 69.17 – 69.18 Mb
831:protein phosphorylation
664:protein kinase activity
624:histone kinase activity
4146:Cell cycle checkpoints
3465:10.1073/pnas.90.8.3521
3227:10.1006/excr.1995.1050
2742:10.1038/sj.onc.1207757
2353:10.1073/pnas.96.5.2147
2265:10.1038/sj.onc.1209202
2217:10.1074/jbc.M302191200
2132:10.1038/sj.onc.1202667
1992:10.1074/jbc.M005319200
1902:10.1074/jbc.M008151200
1398:
735:cyclin B1-CDK1 complex
659:protein kinase binding
63:Human UniProt search:
4173:Other cellular phases
3897:CDK-activating kinase
3597:10.1128/MCB.16.9.4673
3260:10.1083/jcb.128.5.849
2909:10.1242/jcs.101.3.529
1942:10.1128/mcb.19.2.1460
1420:nuclear export signal
1396:
3350:10.1101/gad.7.8.1572
2852:Ann. N. Y. Acad. Sci
2766:Ann. N. Y. Acad. Sci
730:mitochondrial matrix
534:white adipose tissue
321:Chromosome 7 (mouse)
219:Chromosome 5 (human)
80:List of PDB id codes
53:Available structures
3509:1995PNAS...9211889K
3456:1993PNAS...90.3521S
2864:2004NYASA1024..153K
2778:2005NYASA1062...29E
2618:1995PNAS...92.5386D
2344:1999PNAS...96.2147I
1844:1999CBio....9..680H
1689:1998Sci...282..487K
776:tissue regeneration
460:ganglionic eminence
4159:Spindle checkpoint
3964:P53 p63 p73 family
2445:10.1007/BF01269891
1399:
1096:ENSMUSG00000048574
916:mitotic cell cycle
749:Biological process
678:Cellular component
617:Molecular function
4206:
4205:
4202:
4201:
4154:Restriction point
3696:
3695:
2210:(33): 30597–604.
2169:10.1002/jcp.10140
1780:978-1-4613-7693-4
1364:positive feedback
1319:
1318:
1315:
1314:
1288:
1287:
1253:
1252:
1234:
1233:
1200:
1199:
1179:
1178:
1145:
1144:
1128:
1127:
1102:
1101:
1083:
1082:
1057:
1056:
1038:
1037:
986:
985:
861:oocyte maturation
601:
600:
597:
596:
566:
565:
553:
552:
491:
490:
389:
388:
288:
287:
183:CCNB1 - orthologs
137:, CCNB, cyclin B1
115:
114:
111:
110:
16:(Redirected from
4226:
4053:
3723:
3716:
3709:
3700:
3682:
3667:
3647:
3640:
3633:
3624:
3618:
3608:
3575:
3565:
3556:(22): 13283–91.
3540:
3530:
3520:
3503:(25): 11889–93.
3487:
3477:
3467:
3434:
3424:
3415:(11): 8298–308.
3399:
3362:
3352:
3334:
3324:
3314:
3281:
3271:
3238:
3209:
3199:
3166:
3156:
3123:
3113:
3080:
3070:
3037:
3027:
2994:
2957:
2920:
2891:
2833:
2832:
2812:
2806:
2805:
2761:
2755:
2754:
2744:
2720:
2714:
2713:
2698:Clin. Cancer Res
2692:
2686:
2685:
2656:
2650:
2649:
2639:
2629:
2597:
2591:
2590:
2572:
2562:
2538:
2527:
2526:
2498:
2492:
2491:
2471:
2465:
2464:
2428:
2422:
2421:
2411:
2387:
2376:
2375:
2365:
2355:
2323:
2317:
2316:
2299:(12–13): 981–7.
2284:
2278:
2277:
2267:
2243:
2230:
2229:
2219:
2195:
2189:
2188:
2157:J. Cell. Physiol
2151:
2145:
2144:
2134:
2125:(18): 2892–900.
2110:
2104:
2103:
2093:
2061:
2055:
2054:
2011:
2005:
2004:
1994:
1970:
1964:
1963:
1953:
1921:
1915:
1914:
1904:
1880:
1874:
1873:
1855:
1819:
1813:
1812:
1806:
1802:
1800:
1792:
1758:
1752:
1751:
1715:
1709:
1708:
1683:(5388): 487–90.
1672:
1666:
1665:
1658:
1652:
1651:
1623:
1617:
1616:
1605:
1599:
1598:
1587:
1581:
1571:
1560:
1550:
1368:nuclear envelope
1301:
1300:
1272:
1265:
1248:
1238:
1229:
1209:
1205:RefSeq (protein)
1195:
1183:
1174:
1154:
1132:
1113:
1087:
1068:
1042:
1023:
992:
607:
593:
584:
577:
562:
522:secondary oocyte
502:
500:Top expressed in
495:
452:ventricular zone
448:secondary oocyte
440:
438:Top expressed in
433:
412:
395:
385:
372:
361:
346:
339:
333:
322:
310:
294:
284:
271:
260:
245:
238:
232:
221:
207:
191:
185:
136:
129:
106:
77:
71:
50:
49:
44:
32:
21:
4234:
4233:
4229:
4228:
4227:
4225:
4224:
4223:
4209:
4208:
4207:
4198:
4188:
4168:
4140:
4087:
4082:
4068:
4048:
4042:
3986:
3958:
3901:
3808:
3735:
3727:
3697:
3692:
3689:
3683:
3674:
3668:
3654:
3651:
3621:
3585:Mol. Cell. Biol
3578:
3543:
3490:
3437:
3402:
3365:
3332:
3327:
3297:(16): 3772–81.
3284:
3241:
3212:
3169:
3139:(10): 6304–13.
3126:
3096:(12): 7909–16.
3083:
3053:(11): 6859–64.
3040:
3010:(11): 6705–11.
2997:
2960:
2923:
2894:
2845:
2841:
2839:Further reading
2836:
2814:
2813:
2809:
2763:
2762:
2758:
2735:(34): 5843–52.
2722:
2721:
2717:
2694:
2693:
2689:
2668:(18): 2405–12.
2658:
2657:
2653:
2612:(12): 5386–90.
2599:
2598:
2594:
2540:
2539:
2530:
2500:
2499:
2495:
2482:(18): 4159–63.
2473:
2472:
2468:
2430:
2429:
2425:
2389:
2388:
2379:
2325:
2324:
2320:
2286:
2285:
2281:
2258:(12): 1753–62.
2245:
2244:
2233:
2197:
2196:
2192:
2153:
2152:
2148:
2112:
2111:
2107:
2063:
2062:
2058:
2013:
2012:
2008:
1985:(47): 36892–8.
1972:
1971:
1967:
1930:Mol. Cell. Biol
1923:
1922:
1918:
1882:
1881:
1877:
1838:(13): 680–689.
1832:Current Biology
1821:
1820:
1816:
1803:
1793:
1781:
1760:
1759:
1755:
1717:
1716:
1712:
1674:
1673:
1669:
1660:
1659:
1655:
1625:
1624:
1620:
1607:
1606:
1602:
1589:
1588:
1584:
1572:
1563:
1551:
1542:
1538:
1526:
1517:
1508:
1495:
1486:
1469:
1443:
1391:
1341:
1310:View/Edit Mouse
1305:View/Edit Human
1268:
1261:
1258:Location (UCSC)
1246:
1225:
1221:
1217:
1191:
1170:
1166:
1162:
1077:ENSG00000134057
970:
866:spermatogenesis
761:response to DDT
744:
673:
639:protein binding
634:patched binding
629:kinase activity
589:
558:
549:
544:
540:
536:
532:
528:
524:
520:
516:
512:
498:
487:
482:
478:
474:
470:
466:
462:
458:
454:
450:
436:
380:
367:
359:
349:
348:
347:
340:
320:
297:Gene location (
279:
266:
258:
248:
247:
246:
239:
217:
194:Gene location (
145:
132:
125:
86:
64:
28:
23:
22:
15:
12:
11:
5:
4232:
4230:
4222:
4221:
4211:
4210:
4204:
4203:
4200:
4199:
4197:
4196:
4191:
4186:
4182:
4176:
4174:
4170:
4169:
4167:
4166:
4161:
4156:
4150:
4148:
4142:
4141:
4139:
4138:
4133:
4127:
4122:
4117:
4112:
4107:
4097:
4095:
4089:
4088:
4086:
4085:
4080:
4076:
4071:
4066:
4061:
4059:
4050:
4044:
4043:
4041:
4040:
4030:
4025:
4020:
4015:
4010:
4005:
4000:
3994:
3992:
3988:
3987:
3985:
3984:
3979:
3974:
3968:
3966:
3960:
3959:
3957:
3956:
3938:
3911:
3909:
3903:
3902:
3900:
3899:
3894:
3889:
3884:
3879:
3874:
3869:
3864:
3859:
3854:
3849:
3844:
3839:
3834:
3829:
3824:
3818:
3816:
3810:
3809:
3807:
3806:
3792:
3774:
3760:
3745:
3743:
3737:
3736:
3728:
3726:
3725:
3718:
3711:
3703:
3694:
3693:
3691:
3690:
3684:
3677:
3675:
3669:
3662:
3659:
3656:
3655:
3652:
3650:
3649:
3642:
3635:
3627:
3620:
3619:
3591:(9): 4673–82.
3576:
3541:
3488:
3435:
3400:
3363:
3343:(8): 1572–83.
3325:
3282:
3239:
3221:(2): 396–402.
3210:
3182:(8): 1646–54.
3167:
3124:
3081:
3038:
2995:
2958:
2932:(6): 1181–94.
2921:
2892:
2842:
2840:
2837:
2835:
2834:
2823:(15): 4000–4.
2807:
2756:
2715:
2687:
2662:Eur. J. Cancer
2651:
2592:
2528:
2493:
2466:
2423:
2377:
2338:(5): 2147–52.
2318:
2287:Yu M, Zhan Q,
2279:
2231:
2190:
2146:
2105:
2076:(6): 1378–88.
2056:
2029:(5): 833–846.
2006:
1965:
1916:
1875:
1814:
1805:|journal=
1779:
1753:
1710:
1667:
1653:
1618:
1600:
1582:
1561:
1539:
1537:
1534:
1533:
1532:
1525:
1522:
1516:
1513:
1507:
1504:
1494:
1491:
1485:
1482:
1468:
1465:
1442:
1439:
1390:
1387:
1383:nuclear lamins
1351:) to form the
1340:
1337:
1317:
1316:
1313:
1312:
1307:
1297:
1296:
1290:
1289:
1286:
1285:
1283:
1281:
1274:
1273:
1266:
1259:
1255:
1254:
1251:
1250:
1242:
1241:
1235:
1232:
1231:
1213:
1212:
1206:
1202:
1201:
1198:
1197:
1187:
1186:
1180:
1177:
1176:
1158:
1157:
1151:
1147:
1146:
1143:
1142:
1136:
1135:
1129:
1126:
1125:
1117:
1116:
1110:
1104:
1103:
1100:
1099:
1091:
1090:
1084:
1081:
1080:
1072:
1071:
1065:
1059:
1058:
1055:
1054:
1046:
1045:
1039:
1036:
1035:
1027:
1026:
1020:
1014:
1013:
1008:
1003:
999:
998:
988:
987:
984:
983:
972:
971:
969:
968:
963:
958:
953:
948:
943:
938:
933:
928:
923:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
768:
763:
758:
752:
750:
746:
745:
743:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
687:
681:
679:
675:
674:
672:
671:
666:
661:
656:
651:
646:
641:
636:
631:
626:
620:
618:
614:
613:
603:
602:
599:
598:
595:
594:
586:
585:
574:
568:
567:
564:
563:
555:
554:
551:
550:
548:
547:
543:
542:tail of embryo
539:
535:
531:
527:
526:primary oocyte
523:
519:
515:
511:
507:
504:
503:
492:
489:
488:
486:
485:
481:
477:
473:
469:
465:
461:
457:
453:
449:
445:
442:
441:
429:
428:
420:
409:
403:
402:
399:RNA expression
391:
390:
387:
386:
378:
374:
373:
365:
362:
357:
351:
350:
341:
334:
328:
324:
323:
318:
312:
311:
303:
302:
290:
289:
286:
285:
277:
273:
272:
264:
261:
256:
250:
249:
240:
233:
227:
223:
222:
215:
209:
208:
200:
199:
187:
186:
143:
139:
138:
130:
122:
121:
117:
116:
113:
112:
109:
108:
82:
81:
73:
72:
61:
55:
54:
46:
45:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4231:
4220:
4217:
4216:
4214:
4195:
4192:
4190:
4183:
4181:
4178:
4177:
4175:
4171:
4165:
4162:
4160:
4157:
4155:
4152:
4151:
4149:
4147:
4143:
4137:
4134:
4131:
4128:
4126:
4123:
4121:
4118:
4116:
4113:
4111:
4108:
4106:
4102:
4099:
4098:
4096:
4094:
4090:
4084:
4077:
4075:
4072:
4070:
4063:
4062:
4060:
4058:
4054:
4051:
4045:
4038:
4034:
4031:
4029:
4026:
4024:
4021:
4019:
4016:
4014:
4011:
4009:
4006:
4004:
4001:
3999:
3996:
3995:
3993:
3989:
3983:
3980:
3978:
3975:
3973:
3970:
3969:
3967:
3965:
3961:
3954:
3950:
3946:
3942:
3939:
3936:
3932:
3928:
3924:
3920:
3916:
3913:
3912:
3910:
3908:
3907:CDK inhibitor
3904:
3898:
3895:
3893:
3890:
3888:
3885:
3883:
3880:
3878:
3875:
3873:
3870:
3868:
3865:
3863:
3860:
3858:
3855:
3853:
3850:
3848:
3845:
3843:
3840:
3838:
3835:
3833:
3830:
3828:
3825:
3823:
3820:
3819:
3817:
3815:
3811:
3804:
3800:
3796:
3793:
3790:
3786:
3782:
3778:
3775:
3772:
3768:
3764:
3761:
3758:
3754:
3750:
3747:
3746:
3744:
3742:
3738:
3734:
3731:
3724:
3719:
3717:
3712:
3710:
3705:
3704:
3701:
3687:
3681:
3676:
3672:
3666:
3661:
3657:
3648:
3643:
3641:
3636:
3634:
3629:
3628:
3625:
3616:
3612:
3607:
3602:
3598:
3594:
3590:
3586:
3582:
3577:
3573:
3569:
3564:
3559:
3555:
3551:
3550:J. Biol. Chem
3547:
3542:
3538:
3534:
3529:
3524:
3519:
3514:
3510:
3506:
3502:
3498:
3494:
3489:
3485:
3481:
3476:
3471:
3466:
3461:
3457:
3453:
3450:(8): 3521–4.
3449:
3445:
3441:
3436:
3432:
3428:
3423:
3418:
3414:
3410:
3409:J. Biol. Chem
3406:
3401:
3397:
3393:
3389:
3385:
3381:
3377:
3374:(1): 155–64.
3373:
3369:
3364:
3360:
3356:
3351:
3346:
3342:
3338:
3331:
3326:
3322:
3318:
3313:
3308:
3304:
3300:
3296:
3292:
3288:
3283:
3279:
3275:
3270:
3265:
3261:
3257:
3254:(5): 849–62.
3253:
3249:
3245:
3240:
3236:
3232:
3228:
3224:
3220:
3216:
3215:Exp. Cell Res
3211:
3207:
3203:
3198:
3193:
3189:
3185:
3181:
3177:
3173:
3168:
3164:
3160:
3155:
3150:
3146:
3142:
3138:
3134:
3130:
3125:
3121:
3117:
3112:
3107:
3103:
3099:
3095:
3091:
3087:
3082:
3078:
3074:
3069:
3064:
3060:
3056:
3052:
3048:
3044:
3039:
3035:
3031:
3026:
3021:
3017:
3013:
3009:
3005:
3001:
2996:
2992:
2988:
2984:
2980:
2976:
2972:
2969:(5): 833–46.
2968:
2964:
2959:
2955:
2951:
2947:
2943:
2939:
2935:
2931:
2927:
2922:
2918:
2914:
2910:
2906:
2903:(3): 529–45.
2902:
2898:
2893:
2889:
2885:
2881:
2877:
2873:
2869:
2865:
2861:
2858:(1): 153–67.
2857:
2853:
2849:
2844:
2843:
2838:
2830:
2826:
2822:
2818:
2811:
2808:
2803:
2799:
2795:
2791:
2787:
2783:
2779:
2775:
2771:
2767:
2760:
2757:
2752:
2748:
2743:
2738:
2734:
2730:
2726:
2719:
2716:
2711:
2707:
2704:(3): 817–22.
2703:
2699:
2691:
2688:
2683:
2679:
2675:
2671:
2667:
2663:
2655:
2652:
2647:
2643:
2638:
2633:
2628:
2623:
2619:
2615:
2611:
2607:
2603:
2596:
2593:
2588:
2584:
2580:
2576:
2571:
2566:
2561:
2556:
2553:(5): 644–51.
2552:
2548:
2544:
2537:
2535:
2533:
2529:
2524:
2520:
2516:
2512:
2508:
2504:
2497:
2494:
2489:
2485:
2481:
2477:
2470:
2467:
2462:
2458:
2454:
2450:
2446:
2442:
2438:
2434:
2427:
2424:
2419:
2415:
2410:
2405:
2401:
2397:
2396:Am. J. Pathol
2393:
2386:
2384:
2382:
2378:
2373:
2369:
2364:
2359:
2354:
2349:
2345:
2341:
2337:
2333:
2329:
2322:
2319:
2314:
2310:
2306:
2302:
2298:
2294:
2290:
2283:
2280:
2275:
2271:
2266:
2261:
2257:
2253:
2249:
2242:
2240:
2238:
2236:
2232:
2227:
2223:
2218:
2213:
2209:
2205:
2204:J. Biol. Chem
2201:
2194:
2191:
2186:
2182:
2178:
2174:
2170:
2166:
2163:(3): 327–38.
2162:
2158:
2150:
2147:
2142:
2138:
2133:
2128:
2124:
2120:
2116:
2109:
2106:
2101:
2097:
2092:
2087:
2083:
2079:
2075:
2071:
2067:
2060:
2057:
2052:
2048:
2044:
2040:
2036:
2032:
2028:
2024:
2020:
2016:
2010:
2007:
2002:
1998:
1993:
1988:
1984:
1980:
1979:J. Biol. Chem
1976:
1969:
1966:
1961:
1957:
1952:
1947:
1943:
1939:
1936:(2): 1460–9.
1935:
1931:
1927:
1920:
1917:
1912:
1908:
1903:
1898:
1895:(5): 3604–9.
1894:
1890:
1889:J. Biol. Chem
1886:
1879:
1876:
1871:
1867:
1863:
1859:
1854:
1849:
1845:
1841:
1837:
1833:
1829:
1825:
1818:
1815:
1810:
1798:
1790:
1786:
1782:
1776:
1772:
1768:
1764:
1757:
1754:
1749:
1745:
1741:
1737:
1733:
1729:
1726:(4): 579–89.
1725:
1721:
1714:
1711:
1706:
1702:
1698:
1694:
1690:
1686:
1682:
1678:
1671:
1668:
1663:
1657:
1654:
1649:
1645:
1641:
1637:
1633:
1629:
1622:
1619:
1614:
1610:
1604:
1601:
1596:
1592:
1586:
1583:
1579:
1575:
1570:
1568:
1566:
1562:
1558:
1554:
1549:
1547:
1545:
1541:
1535:
1531:
1528:
1527:
1523:
1521:
1514:
1512:
1506:Breast cancer
1505:
1503:
1501:
1493:Tumor antigen
1492:
1490:
1483:
1481:
1477:
1473:
1466:
1464:
1462:
1458:
1454:
1452:
1448:
1440:
1438:
1436:
1431:
1429:
1425:
1421:
1415:
1413:
1409:
1405:
1395:
1388:
1386:
1384:
1378:
1376:
1371:
1369:
1365:
1360:
1358:
1354:
1350:
1346:
1338:
1336:
1334:
1331:
1327:
1323:
1311:
1306:
1302:
1298:
1295:
1291:
1284:
1282:
1279:
1275:
1271:
1267:
1264:
1260:
1256:
1249:
1243:
1239:
1236:
1230:
1228:
1224:
1220:
1214:
1210:
1207:
1203:
1196:
1194:
1188:
1184:
1181:
1175:
1173:
1169:
1165:
1159:
1155:
1152:
1150:RefSeq (mRNA)
1148:
1141:
1137:
1133:
1130:
1124:
1123:
1118:
1114:
1111:
1109:
1105:
1098:
1097:
1092:
1088:
1085:
1079:
1078:
1073:
1069:
1066:
1064:
1060:
1053:
1052:
1047:
1043:
1040:
1034:
1033:
1028:
1024:
1021:
1019:
1015:
1012:
1009:
1007:
1004:
1000:
997:
993:
989:
982:
978:
973:
967:
964:
962:
959:
957:
954:
952:
949:
947:
944:
942:
939:
937:
934:
932:
929:
927:
924:
922:
919:
917:
914:
912:
909:
907:
904:
902:
899:
897:
894:
892:
889:
887:
884:
882:
879:
877:
874:
872:
869:
867:
864:
862:
859:
857:
854:
852:
849:
847:
844:
842:
839:
837:
834:
832:
829:
827:
824:
822:
821:cell division
819:
817:
814:
812:
809:
807:
804:
802:
799:
797:
794:
792:
789:
787:
784:
782:
779:
777:
774:
772:
769:
767:
764:
762:
759:
757:
754:
753:
751:
748:
747:
741:
738:
736:
733:
731:
728:
726:
723:
721:
718:
716:
713:
711:
708:
706:
703:
701:
698:
696:
693:
691:
688:
686:
683:
682:
680:
677:
676:
670:
667:
665:
662:
660:
657:
655:
652:
650:
647:
645:
642:
640:
637:
635:
632:
630:
627:
625:
622:
621:
619:
616:
615:
612:
611:Gene ontology
608:
604:
592:
587:
583:
578:
575:
573:
569:
561:
556:
546:adrenal gland
545:
541:
537:
533:
529:
525:
521:
517:
513:
509:
508:
505:
501:
496:
493:
483:
479:
475:
471:
467:
463:
459:
455:
451:
447:
446:
443:
439:
434:
431:
430:
427:
425:
421:
419:
418:
414:
413:
410:
408:
404:
400:
396:
392:
384:
379:
375:
371:
366:
356:
352:
345:
338:
332:
325:
317:
313:
309:
304:
300:
295:
291:
283:
278:
274:
270:
265:
255:
251:
244:
237:
231:
224:
220:
214:
210:
206:
201:
197:
192:
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
140:
135:
128:
123:
118:
107:
105:
101:
97:
93:
89:
83:
78:
75:
74:
70:
67:
60:
56:
51:
47:
43:
38:
33:
30:
19:
4115:Prometaphase
3766:
3685:
3670:
3588:
3584:
3553:
3549:
3500:
3496:
3447:
3443:
3412:
3408:
3371:
3367:
3340:
3336:
3294:
3290:
3251:
3248:J. Cell Biol
3247:
3218:
3214:
3179:
3175:
3136:
3132:
3093:
3089:
3050:
3046:
3007:
3003:
2966:
2962:
2929:
2925:
2900:
2896:
2855:
2851:
2820:
2816:
2810:
2772:(1): 29–40.
2769:
2765:
2759:
2732:
2728:
2718:
2701:
2697:
2690:
2665:
2661:
2654:
2609:
2605:
2595:
2550:
2546:
2509:(2): 77–81.
2506:
2502:
2496:
2479:
2475:
2469:
2439:(2): 124–7.
2436:
2432:
2426:
2402:(1): 15–23.
2399:
2395:
2335:
2331:
2321:
2296:
2293:Mol. Immunol
2292:
2282:
2255:
2251:
2207:
2203:
2193:
2160:
2156:
2149:
2122:
2118:
2108:
2073:
2069:
2059:
2026:
2022:
2009:
1982:
1978:
1968:
1933:
1929:
1919:
1892:
1888:
1878:
1835:
1831:
1817:
1762:
1756:
1723:
1719:
1713:
1680:
1676:
1670:
1656:
1634:(3): 911–2.
1631:
1627:
1621:
1612:
1603:
1594:
1585:
1518:
1509:
1496:
1487:
1478:
1474:
1470:
1455:
1444:
1441:Interactions
1432:
1416:
1400:
1379:
1372:
1361:
1342:
1329:
1321:
1320:
1245:
1227:NP_001341774
1223:NP_001341773
1216:
1193:XM_036153675
1190:
1172:NM_001354845
1168:NM_001354844
1161:
1139:
1120:
1094:
1075:
1049:
1030:
1010:
1005:
715:cytoskeleton
695:spindle pole
480:right testis
422:
415:
142:External IDs
85:
29:
4136:Cytokinesis
4105:Preprophase
4049:checkpoints
3653:PDB gallery
2897:J. Cell Sci
1515:Lung cancer
1424:Polo kinase
705:nucleoplasm
530:bone marrow
476:left testis
381:41,756,609
368:41,755,323
360:7|7 B3
280:69,178,245
267:69,167,135
120:Identifiers
4057:Interphase
4047:Phases and
3730:Cell cycle
2817:Cancer Res
2547:Cancer Sci
2476:Cancer Res
1580:, May 2017
1559:, May 2017
1536:References
1389:Regulation
1357:cell cycle
871:cell cycle
690:centrosome
514:blastocyst
426:(ortholog)
163:HomoloGene
4180:Apoptosis
4130:Telophase
4120:Metaphase
3915:INK4a/ARF
3337:Genes Dev
1807:ignored (
1797:cite book
1375:condensin
1219:NP_114172
1164:NM_031966
996:Orthologs
685:cytoplasm
171:GeneCards
4213:Category
4125:Anaphase
4110:Prophase
3733:proteins
3396:45351149
3133:J. Virol
3090:J. Virol
3047:J. Virol
3004:J. Virol
2991:20336733
2888:23655886
2880:15265780
2829:10945597
2802:28812067
2794:16461786
2751:15208674
2729:Oncogene
2710:11895914
2682:11720835
2587:24203952
2579:17359284
2570:11159733
2461:10436036
2372:10051609
2313:12009577
2274:16278675
2252:Oncogene
2226:12775724
2185:19138273
2177:12124778
2141:10362260
2119:Oncogene
2100:10716937
2051:20336733
2019:Hunter T
2001:10973963
1911:11060306
1870:10697376
1862:10395539
1826:(1999).
1748:45118388
1628:Genomics
1576:–
1555:–
1530:Cyclin B
1524:See also
1447:interact
1412:cyclin A
1339:Function
1294:Wikidata
975:Sources:
700:membrane
538:testicle
518:yolk sac
464:testicle
4194:Meiosis
4101:Mitosis
4093:M phase
4074:S phase
3941:cip/kip
3615:8756624
3572:8662825
3537:8524869
3505:Bibcode
3484:8475101
3452:Bibcode
3431:8463339
3388:8402895
3359:8101826
3321:8070405
3278:7876309
3269:2120387
3235:7843284
3206:7737117
3163:7666531
3120:7494303
3077:7474100
3034:7474080
2983:2570636
2954:9659637
2946:1836978
2917:1387877
2860:Bibcode
2774:Bibcode
2646:7539916
2614:Bibcode
2523:9950254
2488:8797586
2453:9030252
2418:9006317
2409:1858517
2340:Bibcode
2289:Finn OJ
2043:2570636
2015:Pines J
1960:9891079
1840:Bibcode
1824:Pines J
1789:9552387
1740:2344612
1705:9774278
1685:Bibcode
1677:Science
1648:1386342
1578:Ensembl
1557:Ensembl
1457:GADD45A
1345:mitosis
1326:protein
1108:UniProt
1063:Ensembl
1002:Species
981:QuickGO
725:cytosol
720:nucleus
401:pattern
159:3648694
127:Aliases
4033:Cullin
3919:p14arf
3741:Cyclin
3613:
3606:231467
3603:
3570:
3535:
3525:
3482:
3472:
3429:
3394:
3386:
3357:
3319:
3312:395290
3309:
3291:EMBO J
3276:
3266:
3233:
3204:
3197:398257
3194:
3176:EMBO J
3161:
3154:189529
3151:
3118:
3111:189735
3108:
3075:
3068:189600
3065:
3032:
3025:189580
3022:
2989:
2981:
2952:
2944:
2915:
2886:
2878:
2827:
2800:
2792:
2749:
2708:
2680:
2644:
2634:
2585:
2577:
2567:
2521:
2486:
2459:
2451:
2416:
2406:
2370:
2360:
2311:
2272:
2224:
2183:
2175:
2139:
2098:
2091:305678
2088:
2070:EMBO J
2049:
2041:
1999:
1958:
1951:116074
1948:
1909:
1868:
1860:
1787:
1777:
1746:
1738:
1703:
1646:
1467:Cancer
1461:RALBP1
1280:search
1278:PubMed
1122:P14635
1051:434175
1018:Entrez
572:BioGPS
510:morula
484:rectum
259:5q13.2
151:123836
4189:phase
4083:phase
4069:phase
4008:Cdc42
4003:Cdc25
3991:Other
3773:, B3)
3528:40508
3475:46332
3392:S2CID
3333:(PDF)
2987:S2CID
2950:S2CID
2884:S2CID
2798:S2CID
2637:41699
2583:S2CID
2457:S2CID
2363:26751
2181:S2CID
2047:S2CID
1866:S2CID
1744:S2CID
1500:ELISA
1449:with
1408:Cdc25
1330:CCNB1
1324:is a
1011:Mouse
1006:Human
977:Amigo
456:gonad
424:Mouse
417:Human
364:Start
299:Mouse
263:Start
196:Human
175:CCNB1
167:68982
134:CCNB1
35:CCNB1
18:CCNB1
4037:CUL7
3998:Cdc2
3686:2jgz
3671:2b9r
3611:PMID
3568:PMID
3533:PMID
3480:PMID
3427:PMID
3384:PMID
3368:Cell
3355:PMID
3317:PMID
3274:PMID
3231:PMID
3202:PMID
3159:PMID
3116:PMID
3073:PMID
3030:PMID
2979:PMID
2963:Cell
2942:PMID
2926:Cell
2913:PMID
2876:PMID
2856:1024
2825:PMID
2790:PMID
2770:1062
2747:PMID
2706:PMID
2678:PMID
2642:PMID
2575:PMID
2519:PMID
2484:PMID
2449:PMID
2414:PMID
2368:PMID
2309:PMID
2270:PMID
2222:PMID
2173:PMID
2137:PMID
2096:PMID
2039:PMID
2023:Cell
1997:PMID
1956:PMID
1907:PMID
1858:PMID
1809:help
1785:PMID
1775:ISBN
1736:PMID
1720:Cell
1701:PMID
1644:PMID
1459:and
1451:Cdk1
1428:Cdk1
1426:and
1404:Wee1
1349:Cdk1
1333:gene
407:Bgee
355:Band
316:Chr.
254:Band
213:Chr.
147:OMIM
104:4YC3
100:5HQ0
96:4Y72
92:2JGZ
88:2B9R
69:RCSB
66:PDBe
4028:Wee
4018:E2F
3982:p73
3977:p63
3972:p53
3953:p57
3949:p27
3945:p21
3935:p19
3931:p18
3927:p15
3923:p16
3877:11B
3872:11A
3814:CDK
3601:PMC
3593:doi
3558:doi
3554:271
3523:PMC
3513:doi
3470:PMC
3460:doi
3417:doi
3413:268
3376:doi
3345:doi
3307:PMC
3299:doi
3264:PMC
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